ライフサイエンスコーパス: DNA cleavage

1 ining, RNA degradation, and oligonucleosomal DNA cleavage).

2 increase levels of topoisomerase II-mediated DNA cleavage).

3 mer competent for non-specific double-strand DNA cleavage.

4 recombination intermediates may drive biased DNA cleavage.

5 eins use a conserved catalytic mechanism for DNA cleavage.

6 exerts a conformational control domain over DNA cleavage.

7 e, the most therapeutically valuable type of DNA cleavage.

8 form a cruciform structure that facilitates DNA cleavage.

9 dation of mutant mtDNA through site-specific DNA cleavage.

10 ide RNAs (gRNAs) to direct sequence-specific DNA cleavage.

11 and is necessary for efficient Ref-mediated DNA cleavage.

12 SPDL motifs position the strand for accurate DNA cleavage.

13 tional mechanisms must restrict RAG-mediated DNA cleavage.

14 C2c1 depends on both crRNA and tracrRNA for DNA cleavage.

15 functional protein capable of site-specific DNA cleavage.

16 full-length Cas9 and catalyzes site-specific DNA cleavage.

17 died in vitro, where light activation caused DNA cleavage.

18 o PAM-mediated stimulation of Cas9-catalysed DNA cleavage.

19 A5 was used to assess sites of double-strand DNA cleavage.

20 ormation of normally transient double strand DNA cleavage.

21 may employ a unique catalytic mechanism for DNA cleavage.

22 erse transcription and conduct second-strand DNA cleavage.

23 he iron-sulfur cluster, but had no effect on DNA cleavage.

24 e responsive to targeted HPV genome-specific DNA cleavage.

25 sess a sequence-specific ATPase activity for DNA cleavage.

26 condary to salicylate-mediated inhibition of DNA cleavage.

27 oligonucleotides attached to Rec12 following DNA cleavage.

28 ate metal ions of different atomic radii for DNA cleavage.

29 level of homolog pairing precedes programmed DNA cleavage.

30 shown to facilitate RNA-guided site-specific DNA cleavage.

31 ach case for inhibition of SauCas9-catalyzed DNA cleavage.

32 as9 is the limiting factor for Cas9-mediated DNA cleavage.

33 slocation to the nucleus, where it initiates DNA cleavage.

34 ly 360 ns in H(2)O) which is responsible for DNA cleavage.

35 stable ~9 bp R-loop that could not activate DNA cleavage.

36 recombination involving transposase-mediated DNA cleavage.

37 turmeric enhanced topoisomerase II-mediated DNA cleavage.

38 et sequence recognition and protein-mediated DNA cleavage.

39 tosine base at the -4 position to facilitate DNA cleavage.

40 acid, and feruloylmethane, had no effect on DNA cleavage.

41 uring long-range communication and following DNA cleavage.

42 or DNA binding and a secondary selection for DNA cleavage.

43 hat could otherwise result from RAG-mediated DNA cleavage.

44 this function is separable from its role in DNA cleavage.

45 s can catalyse Z-site-specific double-strand DNA cleavage.

46 ssed SOS induction as a readout of increased DNA cleavage.

47 stood but is associated with enzyme-mediated DNA cleavage.

48 erases has a more stringent requirement than DNA cleavage.

49 laining some ensemble biochemical results on DNA cleavage.

50 A:tracrRNA-FnoCas9 machinery can also direct DNA cleavage.

51 n for GTP hydrolysis-dependent activation of DNA cleavage.

52 tation indicates a low level of nonselective DNA cleavage.

53 to be a critical component of second-strand DNA cleavage.

54 es appropriately positioned and oriented for DNA cleavage.

55 a stable product state after double-stranded-DNA cleavage.

56 transition mutations without double-stranded DNA cleavage.

57 ashion primes MjAgo for subsequent rounds of DNA cleavage.

58 e2, and internal protein blocks also trigger DNA cleavage.

59 ble tethering of the nuclease domains during DNA cleavage.

60 topoII poisons that enhance enzyme-mediated DNA cleavage, a mechanism that is linked to the developm

61 By combining the single-stranded DNA cleavage ability of CRISPR-Cas12a and the competitiv

62 Here we examine the DNA cleavage activities and substrate requirements of Nm

63 d 6'-deoxy-BLM Z and the evaluation of their DNA cleavage activities as a measurement for their poten

64 n, ferulic acid, and feruloylmethane) on the DNA cleavage activities of human topoisomerase IIalpha a

65 hen activated and possesses both accelerated DNA cleavage activity and expanded DNA sequence specific

66 NA binding protein Cas9 that have lost their DNA cleavage activity could be used to recruit transcrip

67 DNA cleavage activity does not depend on cleavage of the

68 Purified Sco5333 and Tbis1 displayed weak DNA cleavage activity in the presence of Mg(2+), Mn(2+)

69 is study provides a structural basis for the DNA cleavage activity of 1, will guide the design of syn

70 otection of the host genome against damaging DNA cleavage activity of activated SgrAI.IMPORTANCE This

71 haride moiety plays an important role in the DNA cleavage activity of BLMs and ZBMs, (ii) the ZBM dis

72 nsects, which leverage the sequence-targeted DNA cleavage activity of CRISPR-Cas9 and endogenous homo

73 previously unappreciated regulatory roles of DNA cleavage activity on Cas9's conformation and suggest

74 munication has been suggested to control its DNA cleavage activity through flexibility of the catalyt

75 mbly of synaptic complexes and regulation of DNA cleavage activity via trans protein-protein interact

76 Metnase DNA cleavage activity was not required for Exo1 5'-exonu

77 R-loop formation and DNA cleavage activity were also essentially unaffected b

78 oreover, we find that CdCas9 exhibits robust DNA cleavage activity with the optimal 22-nucleotide len

79 g tool selects target sites, avoids spurious DNA cleavage activity, and controls DNA recombination ef

80 hese overhangs but did not require Metnase's DNA cleavage activity.

81 s translated into corresponding asymmetry in DNA cleavage activity.

82 of the HNH nuclease domain directly controls DNA cleavage activity.

83 Moreover, it holds a strong ATP-inhibited DNA cleavage activity.

84 rm dsDNA binding is a good predictor for RNA/DNA cleavage activity.

85 ly broad 5'-NNG-3' PAM compatibility, robust DNA-cleavage activity and minimal off-target activity.

86 ercial electrode assembly and treated in the DNA cleavage agent formed by the Fenton type reaction.

87 y the monomeric diazofluorene 11 as a potent DNA cleavage agent in tissue culture.

88 guide the design of synthetic DNA-activated DNA cleavage agents, and underscores the utility of natu

89 , are demonstrated to be much less effective DNA cleavage agents, thereby providing an explanation fo

90 Kinetic DNA cleavage and ATPase measurements implicate R79 in mo

91 n be attained in early S phase, resulting in DNA cleavage and cell death.

92 g target RNA-binding-dependent activation of DNA cleavage and cOA generation remain unknown.

93 e Csm1 subunit that allosterically activates DNA cleavage and cOA generation.

94 e show the bulge and nexus are necessary for DNA cleavage and demonstrate that the nexus and hairpins

95 bination reaction, which can be divided into DNA cleavage and DNA joining steps.

96 resistance to cleavage enzymes may occur if DNA cleavage and error prone repair does not render the

97 ion requires the enzyme to precisely control DNA cleavage and gate opening coupled with ATP hydrolysi

98 , Cas12c (C2c3)- and Cas12d (CasY)-catalyzed DNA cleavage and genome editing activities have not been

99 that Type III RM enzymes can dissociate upon DNA cleavage and go on to cleave further DNA molecules (

100 cleases that use dual-RNAs for site-specific DNA cleavage and highlights the potential to exploit the

101 leavage at high drug concentrations, whereas DNA cleavage and inhibition of religation occurs at low

102 ed rotation' of the synaptic complex between DNA cleavage and joining.

103 erminal domain to core-type DNA sites, where DNA cleavage and ligation are executed.

104 plied in host organisms, they enable precise DNA cleavage and ligation without the gain or loss of nu

105 Previous studies have focused on examining DNA cleavage and ligation; however, the dynamic opening

106 leave and package viral DNA, suggesting that DNA cleavage and packaging are inextricably linked.

107 acts with pUL28, but its precise role in the DNA cleavage and packaging reaction is unclear.

108 minase subunit), A374V in UL32 (required for DNA cleavage and packaging), V296I in UL42 (encoding the

109 yrB subunits, that catalyzes double-stranded DNA cleavage and passage of a second double-stranded DNA

110 uclease targets the submicron locus, causing DNA cleavage and recruiting repair factors such as GFP-5

111 s that must coordinate fuel consumption with DNA cleavage and religation and with numerous conformati

112 exploration of the kinetics of Cas9-mediated DNA cleavage and repair.

113 equired to produce maximal quinolone-induced DNA cleavage and restricted the divalent metal ions that

114 Second-strand DNA cleavage and second-strand DNA synthesis were invest

115 TnpA is in an activated state competent for DNA cleavage and strand transfer.

116 he amino acid was important for DNA bending, DNA cleavage and supercoil relaxation.

117 mice brain by combining CRISPR-Cas9-mediated DNA cleavage and the efficient delivery of donor templat

118 The Cu(GTSCHCl) complex caused distinct DNA cleavage and Topo IIalpha inhibition unlike that for

119 RAG recombinase with appropriately regulated DNA cleavage and transposition activities are not unders

120 as concluded that the observed double-strand DNA cleavage and very low sequence selectivity by shishi

121 apoptosis confirmed by nuclear condensation, DNA cleavage, and accumulation of S phase cell arrest.

122 cleavage, RNA target-dependent non-specific DNA cleavage, and cOA generation.

123 in each step of transposition: DNA binding, DNA cleavage, and DNA strand transfer.

124 n appears to be topoisomerase II inhibition, DNA cleavage, and free radical generation.

125 and poly(ADP-ribose) polymerase processing, DNA cleavage, and JNK phosphorylation.

126 of RAG1, which contains the active site for DNA cleavage, and RAG2, an accessory factor whose intera

127 arly stage of transpososome assembly, before DNA cleavage, and that mutations affecting immunity have

128 complexes that are blocked at steps prior to DNA cleavage are also described.

129 Over 95% of tested sgRNA induced specific DNA cleavage as measured by CEL-1 assays.

130 olecules were evaluated in the Top1-mediated DNA cleavage assay and in the National Cancer Institute'

131 eing used as a standard in the Top1-mediated DNA cleavage assay.

132 In vivo phage plaque assays and in vitro DNA cleavage assays show that AcrIIC2(Nme) mediates its

133 nt expression in tobacco leaves and in vitro DNA cleavage assays, respectively.

134 However, H5' abstraction can lead DNA cleavage at 5' end through the formation of C5'=O5'

135 othermophilus (GeoCas9) catalyzes RNA-guided DNA cleavage at elevated temperatures.

136 Free DNA binding suppresses Top1-catalyzed DNA cleavage at high drug concentrations, whereas DNA cl

137 ether and how PAM binding activates Cas9 for DNA cleavage at spatially distant sites.

138 ce for DNA, enzyme and drug contributions to DNA cleavage at the gate, suggest a mechanism for DNA di

139 to exchange DNA strands after double-strand DNA cleavage at the two recombining att sites, and that

140 te-specific RAG endonuclease, which mediates DNA cleavage at two recombining gene segments and their

141 However, off-target DNA cleavages at unknown sites can lead to mutations tha

142 up to 100 degrees C in vitro, which enables DNA cleavage beyond the 44 degrees C limit of Streptococ

143 portant not only for regulating RAG-mediated DNA cleavage but also for the efficiency of RAG recruitm

144 donuclease requiring divalent metal ions for DNA cleavage but not for binding.

145 evidence for looping being a requirement for DNA cleavage, but instead support a diffusive sliding of

146 re recognized as promising intermediates for DNA cleavage, but their formation has thus far been limi

147 ed improvements in the precision of targeted DNA cleavage, but they often restrict the range of targe

148 om 1, provide insights into the mechanism of DNA cleavage by 1.

149 provide mechanistic insights into RNA-guided DNA cleavage by Cpf1 and establish a framework for ratio

150 Unexpectedly, Mg(2+)-catalyzed DNA cleavage by EcoRI is profoundly inhibited by Cu(2+)

151 DNA cleavage by fCas9 requires association of two fCas9

152 ge reactions; DNA 13 underwent double-strand DNA cleavage by independent single-strand cleavages at a

153 es the inhibitory effect of RAD51 on 3'-flap DNA cleavage by MUS81-EME1 through its RAD51 filament di

154 We show that ATP-dependent DNA cleavage by R-proteins occurs at fixed positions (6-

155 TP/s/monomer) are required for site-specific DNA cleavage by R-proteins.

156 esidue (K233) results in a large increase of DNA cleavage by RAG1/2.

157 oint to an unusual mechanism of PT-dependent DNA cleavage by restriction enzymes in the face of parti

158 Simulations of DNA cleavage by SgrAI uncover the origins of the kinetic

159 create guide RNAs that direct site-specific DNA cleavage by the Cas9 endonuclease in cultured cells.

160 we found that the target RNA per se induces DNA cleavage by the Cmr complex in vitro.

161 rstanding of the PAM-dependent, crRNA-guided DNA cleavage by the Cpf1 family nucleases.

162 The AAA+ GTPase McrB powers DNA cleavage by the endonuclease McrC.

163 d the ribonuclease Csm6, rather than through DNA cleavage by the HD domain.

164 In analyzing site-specific DNA cleavage by the mammalian RAG1-RAG2 recombinase, whi

165 MutSgamma directly stimulates DNA cleavage by the MutLgamma endonuclease.

166 DNA cleavage by the Type III restriction enzymes require

167 DNA cleavage by the Type III Restriction-Modification (R

168 te positioned at the active site for optimal DNA cleavage by the tyrosine hydroxyl nucleophile to fac

169 This accelerated site-specific DNA cleavage by the zinc-finger nuclease, without enhanc

170 Upon transcript binding, DNA cleavage by type III effector complexes is activated

171 e corresponding Arg-321 mutation showed that DNA cleavage can still take place in the absence of this

172 es were compared with BLM and deglycoBLM for DNA cleavage, cancer cell uptake, and cytotoxic activity

173 reaks (DSBs) mediated by Topoisomerase 2beta-DNA cleavage complex (TOP2betacc) intermediates are requ

174 ) affect the binding of the drug to the Top1-DNA cleavage complex and thus modulate the drug's Top1 i

175 inolone binding site in the topoisomerase IV-DNA cleavage complex but does not form significant conta

176 ch as camptothecin (CPT), stabilize the Top1-DNA cleavage complex in a DNA sequence-dependent manner.

177 s able to stabilize the transient DNA gyrase-DNA cleavage complex, a very efficient mode of action sh

178 system on the ability to stabilize the Top1-DNA cleavage complex.

179 icancer activity by reversibly trapping Top1-DNA cleavage complexes (Top1cc's) and inducing replicati

180 Compound 28 traps Top1-DNA cleavage complexes (Top1ccs) both in the in vitro cl

181 ulation of pathogenic topoisomerase-1 (Top1)-DNA cleavage complexes (Top1ccs) in murine models of ata

182 erations cause potentially irreversible Top2.DNA cleavage complexes (Top2cc), leading to Top2-linked

183 Topoisomerase IIbeta (Top2beta)-DNA cleavage complexes are known to arrest elongating RN

184 bacterial topoisomerase inhibitors, can trap DNA cleavage complexes with double- or single-stranded c

185 cterial thiophenes stabilize gyrase-mediated DNA-cleavage complexes in either one DNA strand or both

186 erials that target DNA gyrase by stabilizing DNA-cleavage complexes, but their clinical utility has b

187 I requires K(+) ions to prevent non-specific DNA cleavage, conditions which affect the translocation

188 nt antiproliferative effect of Cas9-mediated DNA cleavage confounds such measurement of genetic depen

189 rmined the 2.9-A-resolution structure of the DNA cleavage core of human topoisomerase IIalpha (TOP2A)

190 ha and -beta occupancy and etoposide-induced DNA cleavage data suggest factors other than local topoi

191 We introduce on-chip lysis and non-enzymatic DNA cleavage directly followed by a purifying step for r

192 er pylori (R.HpyAXII) and demonstrated their DNA cleavage, DNA glycosylase and AP lyase activities in

193 inal DNA-recognition domain and a C-terminal DNA cleavage domain.

194 DNA-binding modules linked to a nonspecific DNA cleavage domain.

195 embly of zinc finger DNA-binding domain to a DNA-cleavage domain enables the enzyme machinery to targ

196 e highlight the function of RNA in mediating DNA cleavage during genome rearrangements and pathogen d

197 uclease and helicase activities required for DNA cleavage during interference.

198 pecific endonuclease that catalyzes specific DNA cleavage during V(D)J recombination, which is requir

199 ed with on- and off-target DNA, we find that DNA cleavage efficiencies scale with the extent to which

200 the presence of mutated phage targets, when DNA cleavage efficiency is reduced.

201 While CRISPR/Cas9 executes double-stranded DNA cleavage efficiently, closure of the broken chromoso

202 the benefits and drawbacks of three types of DNA cleavage enzymes (zinc finger endonucleases, transcr

203 deal scaffolds for engineering site-specific DNA cleavage enzymes for genome editing applications.

204 We are currently engineering DNA cleavage enzymes that specifically target hepatitis

205 leases (meganucleases) are sequence-specific DNA cleavage enzymes used for genome engineering.

206 DNA cleavage enzymes will be delivered as genes within v

207 DNA cleavage enzymes, including homing endonucleases or

208 e the delivery and intracellular activity of DNA cleavage enzymes.

209 ed to amplified loci, the resulting multiple DNA cleavage events can be a cause of false positive hit

210 We propose that DNA cleavage events mediated by RAG endow developing ada

211 pUL33 is necessary for one of the two viral DNA cleavage events required to release individual genom

212 per shows a role for pUL33 in one of the two DNA cleavage events required to release monomeric genome

213 tial rapid endonuclease activity, additional DNA cleavage events then occur more slowly, leading to f

214 inetics of these endonucleases by monitoring DNA cleavage events with deep sequencing.

215 se pair into another without double-stranded DNA cleavage, excess stochastic insertions and deletions

216 In addition, double-stranded supercoiled DNA-cleavage experiments with shishijimicin A in competi

217 lies on guide RNAs that direct site-specific DNA cleavage facilitated by the Cas endonuclease.

218 chromatin condensation, nuclear lamin A and DNA cleavage, fragmentation of the nuclear envelope, and

219 DNA cleavage guided by a single CRISPR RNA generated lar

220 Coordinated domain motions of Cas9 prior to DNA cleavage have been extensively characterized but our

221 ne = 1,10-phenanthroline-5,6-dione, leads to DNA cleavage in an oxygen independent manner.

222 off-target analysis to assess Cas9-mediated DNA cleavage in human cells, we demonstrate that "enhanc

223 on of the cut site and increases the rate of DNA cleavage in modified versus unmodified junctions.

224 hile the aglycon (deglycobleomycin) mediates DNA cleavage in much the same fashion as bleomycin, it e

225 e results reveal the role of endonucleolytic DNA cleavage in restriction and yet point to diversity a

226 cell lines through MRE11 and MUS81-mediated DNA cleavage in S phase cells.

227 on that restriction enzymes caused extensive DNA cleavage in the absence of PT modifications in vivo.

228 companied by reduced transient double-strand DNA cleavage in the rDNA-promoter region and reduced pre

229 tyrosine hydroxyl nucleophile to facilitate DNA cleavage in the reaction pathway.

230 al regions of the sgRNA and allows efficient DNA cleavage in vitro as well as gene-editing in cells w

231 te that mutants perturbing ATP hydrolysis or DNA cleavage in vitro impair P2 OLD-mediated killing of

232 sigmoidal in nature, and rates and levels of DNA cleavage increased when metal ion mixtures were used

233 N-terminal sequence that is dispensable for DNA cleavage inhibition and have divergent C termini tha

234 supercoiling, decatenation, DNA binding, and DNA cleavage inhibition assays.

235 displacement mechanism instead of oxidative DNA cleavage is confirmed by denaturing gel electrophore

236 pH-gated light-activated double-strand (ds) DNA cleavage is controlled by variations in electronic a

237 A design to improve the efficiency of target/DNA cleavage is critical to ensure the success of CRISPR

238 Whereas DNA cleavage is essential for immunity, the function of

239 DNA cleavage is executed by Cas9, which uses two distinc

240 We show that DNA cleavage is impaired by more than 100- fold for the

241 Evidence suggests DNA cleavage is initiated by hydrogen atom abstraction f

242 anding of repair outcomes after Cas9-induced DNA cleavage is still limited, especially in primary hum

243 tors disable Cas12a by preventing programmed DNA cleavage is unknown.

244 exhibit reduced chromatin decompaction after DNA cleavage, lesser focal recruitment of homologous rec

245 DNA cleavage mechanism of AgeI is novel among Type IIP r

246 Here, we report studies to evaluate the DNA cleavage mechanism of CglI.

247 Taking advantage of the sequential DNA cleavage mechanism of I-DmoI LAGLIDADG homing endonu

248 The type of DNA cleavage might alter the balance between these two a

249 generate a tetramer with two double-stranded DNA cleavage modules.

250 e., for strongly bound DNAs, the facility of DNA cleavage must involve other parameters in addition t

251 nt protein that lacks endonuclease activity, DNA cleavage of the 3'-5' strand relative to the wild-ty

252 bp/s at 25 degrees C) and a requirement for DNA cleavage of two recognition sites in an inverted hea

253 biosensors were reported using DNAzymes with DNA cleavage or DNA ligation activity.

254 arse the roles of individual proteins in the DNA cleavage/packaging reaction.

255 g biophysical properties that correlate with DNA cleavage patterns.

256 While having unexceptional DNA cleavage potencies, both glycosylated analogues were

257 We describe an unprecedented DNA-catalyzed DNA cleavage process in which a radical-based reaction p

258 ted with our simulations that Cas9-catalyzed DNA cleavage produces 1-bp staggered ends rather than ge

259 critical issue, this study characterized the DNA cleavage reaction of Escherichia coli topoisomerase

260 bservations, unrelated DNA-catalyzed radical DNA cleavage reactions require redox-active metals and l

261 Key to this capability are targetable DNA cleavage reagents and cellular DNA repair pathways.

262 of MtTOP1 was expressed and found to retain DNA cleavage-religation activity and catalyze single-str

263 of the putative active site residues in the DNA cleavage/religation process.

264 rajectories along the catalytic paths of the DNA cleavage/religation steps.

265 of TerL variants for defects in binding and DNA cleavage, revealing that the ATPase domain is the pr

266 casionally leads to autoimmunity due to self-DNA cleavage (self-restriction) [8].

267 7-azaindenoisoquinolines intercalate at the DNA cleavage site in DNA-Top1 covalent complexes with th

268 calate between two base pairs outside of the DNA cleavage site, has been suggested to promote deforma

269 y for a cytosine base 4 nt upstream from the DNA cleavage site.

270 equence that is directly centered across the DNA cleavage site.

271 Initial DNA cleavage sites and end trimming varied by nuclease,

272 age distinguished 'intrinsic recognition' of DNA cleavage sites by topo IV from drug-induced preferen

273 t redistribute CTCF/cohesin occupancy rewire DNA cleavage sites to novel loop anchors.

274 The DNA cleavage sites were analyzed using ICM Molsoft softw

275 e tetramer and engaged with the enzyme's two DNA-cleavage sites.

276 oth an online archive of LHEs with validated DNA cleavage specificities and DNA-binding interactions,

277 f an extensive set of HE variants with novel DNA cleavage specificities using an integrated experimen

278 However, its pattern of DNA cleavage specificity is different and it is resistan

279 ors nucleases (TALENs) with broadly improved DNA cleavage specificity, establishing DB-PACE as a vers

280 To improve DNA cleavage specificity, we generated fusions of cataly

281 und structures suggest common mechanisms for DNA cleavage-stabilizing compounds.

282 This reaction is initiated through a DNA cleavage step by the RAG1 and RAG2 proteins, which t

283 This DNA cleavage step is followed by a joining step, during

284 up to 11 base pairs in length, which prevent DNA cleavage, still allow formation of a stable complex

285 Kinetic analysis of DNA cleavage suggests flexible tethering of the nuclease

286 kaging series initiates with double-stranded DNA cleavages that are scattered across a 170-bp region

287 reas [Ru(phen)(3)](2+)* does not show direct DNA cleavage, the deprotonated form of 1H(2)O(2+)* does

288 bility because it regulates FEN1's potential DNA cleavage threat near the site of replication.

289 veral studies have focused on correcting for DNA cleavage toxicity biases associated with copy number

290 Programmable DNA cleavage using CRISPR-Cas9 enables efficient, site-s

291 e have also analyzed the metal dependence of DNA cleavage using Mg(2+) ions at different concentratio

292 In vitro, etoposide-stabilized DNA cleavage was attenuated by doxorubicin, epirubicin,

293 No DNA cleavage was detected in cells infected with a U(L)1

294 Gel electrophoresis results confirmed that DNA cleavage was not a major inactivating mechanism.

295 In addition, the metal-ion dependence of DNA cleavage was sigmoidal in nature, and rates and leve

296 ablish the role of this sequence in accurate DNA cleavage, we have determined the crystal structure o

297 We mapped DNA cleavage when a translocating enzyme collides with a

298 opoisomerase-induced DNA breaks, we map Top2 DNA cleavage with strand-specific nucleotide resolution

299 AP mediated DNA cleavage within NCPs is initiated by DNA-protein cro

300 hat DNA binding is far more promiscuous than DNA cleavage, yet the molecular cues that govern strand