ライフサイエンスコーパス: DNA deletion

1 h element was sufficient to inhibit specific DNA deletion.

2 ear to be responsible for gene silencing and DNA deletion.

3 30-nt small RNAs known to be associated with DNA deletion.

4 on the location and length of the telomeric DNA deletion.

5 ate of DNA influx is balanced by the rate of DNA deletion.

6 parently because of its high rate of genomic DNA deletion.

7 d on the frequency of a single mitochondrial DNA deletion.

8 nce basis for misalignment in the process of DNA deletion.

9 e-site mutations and in the patient with the DNA deletion.

10 luding site-specific chromosome breakage and DNA deletion.

11 h, and body mass is negatively correlated to DNA deletions.

12 legia associated with multiple mitochondrial DNA deletions.

13 xygen species, transmembrane instability, or DNA deletions.

14 s sequences resulting in a high frequency of DNA deletions.

15 vels and, as a genetic instability endpoint, DNA deletions.

16 guanosine, gamma-H2AX foci, micronuclei, and DNA deletions.

17 II) significantly increased the frequency of DNA deletions.

18 ank two-thirds of the reported mitochondrial DNA deletions.

19 able of detecting submicroscopic chromosomal DNA deletions.

20 cient mice display an increased frequency of DNA deletions.

21 stant sites of microhomology, creating large DNA deletions.

22 -targeting vectors to generate large genomic DNA deletions.

23 ht patients (67%) had a single mitochondrial DNA deletion, 12 (10%) had a point mutation of mitochond

24 ower in patients with a single mitochondrial DNA deletion (2%) as compared to those with a point muta

25 To generate DNA deletions, a tandem array of class IIS restriction e

26 any age-dependent increases in mitochondrial DNA deletions also detected by the long polymerase chain

27 Using DNA deletion analysis of the 5'-flanking region of promo

28 DNA deletion analysis of the fis promoter (fis P) region

29 n by nuclear run-on transcription assays and DNA deletion analysis of transfected SCD1-chloramphenico

30 ry chain defects, secondary to mitochondrial DNA deletion and depletion, are likely to be responsible

31 These results indicated that DNA deletion and recombination had occurred in either ci

32 Moreover, the D6 sequence showed evidence of DNA deletion and substitution in this region relative to

33 nd IV due to clonally-expanded mitochondrial DNA deletions and a significant reduction in mitochondri

34 The results show that mitochondrial DNA deletions and cytochrome c oxidase-deficient cones a

35 efects and single, large-scale mitochondrial DNA deletions and is less frequently associated with poi

36 DNA deletions and other genome rearrangements are involv

37 l, progressive accumulation of mitochondrial DNA deletions and point mutations accompanied by increas

38 Mitochondrial DNA deletions and point mutations accumulate in an age-d

39 dentified sporadic large-scale mitochondrial DNA deletions and variants in MT-TL1, MT-ATP6, MT-TK, MT

40 ibit homology-directed repair (HDR), causing DNA deletions and vulnerablility to PARP inhibitors.

41 uric acid-reactive substances, mitochondrial DNA deletions, and renal expression of fibrogenic genes,

42 ve end joining mechanism that creates larger DNA deletions, and uses longer microhomology compared to

43 P1, CCNJ, CHST2/7, CLEC12A/B, and PTPRM; ERG DNA deletions; and 4-year relapse-free survival of 94.7%

44 Mitochondrial DNA deletions are prominent in human genetic disorders,

45 use microcytic anemia, whereas mitochondrial DNA deletions are responsible for Pearsons syndrome with

46 ve stress and genetic instability, including DNA deletions, are involved in carcinogenesis.

47 DNA deletion assays may be sensitive indicators for carc

48 ay a role in the generation of mitochondrial DNA deletions associated with a number of human patholog

49 es by causing chromosomal translocations and DNA deletions at cancer genes.

50 within 20 base pairs) to known mitochondrial DNA deletion breakpoints.

51 inding in patients with single mitochondrial DNA deletions but that it is highly predictive of an und

52 The frequency of DNA deletions by homologous recombination at the pink-ey

53 arbons in genotoxicity assays that score for DNA deletions by intrachromosomal recombination in vivo

54 Inherent disorders of mitochondria such as DNA deletions cause major disruption of metabolism and c

55 lation of peripheral T cells enriched in the DNA deletion circles created by alphabeta and gammadelta

56 RAG-2, bind and cleave the cRSS to generate DNA deletion circles during the V(H) replacement process

57 ectomy resulted in the gradual loss of these DNA deletion circles in all of the peripheral lymphoid t

58 dase-deficient fibers revealed mitochondrial DNA deletions, consistent with damage from oxidative str

59 romoter-intron reporter assays using various DNA deletion constructs indicated that several HIF-1 bin

60 large-scale genomic rearrangements, such as DNA deletions, duplications, and translocations.

61 sion of the RNA hairpin also causes targeted DNA deletion during conjugation, although at low efficie

62 Ab isotype is mediated by a recombinational DNA deletion event and must be robustly upregulated duri

63 Approximately 6000 specific DNA deletion events occur during development of the soma

64 cient cells (rho(-)) harboring mitochondrial DNA deletion exhibit dependency on glycolysis, increased

65 The multiple mitochondrial DNA deletions found in skeletal muscle revealed a mitoch

66 nts in the Cx40 promoter region, a series of DNA deletion fragments flanking exon I was prepared, sub

67 t (<25 bp), but unpredictable on-target long DNA deletions (>500 bp) can be observed.

68 Many cancers harbor homozygous DNA deletions (HDs).

69 l phage resistance mechanism via chromosomal DNA deletion in P. aeruginosa.

70 Recent molecular studies on DNA deletion in Tetrahymena have revealed two interestin

71 ference (RNAi) has been linked to programmed DNA deletion in the ciliate Tetrahymena thermophila.

72 ro can induce the formation of mitochondrial DNA deletions in a PCR detection assay.

73 most common cause of multiple mitochondrial DNA deletions in adults, following POLG [polymerase (DNA

74 of oxidative DNA damage and the frequency of DNA deletions in Atm-deficient (AT-mutated) mice.

75 OH deoxyguanosine level and the frequency of DNA deletions in Atm-deficient mice.

76 orf2 or RRM2B, or had multiple mitochondrial DNA deletions in muscle without an identified nuclear ge

77 leven patients showed multiple mitochondrial DNA deletions in skeletal muscle and 67% showed ragged r

78 ither with or without multiple mitochondrial DNA deletions in skeletal muscle.

79 he question of the spectrum of mitochondrial DNA deletions in skin and whether this can be used as an

80 was a significant increase in the number of DNA deletions in the embryo as evidenced by spotted offs

81 -deficient fibres and multiple mitochondrial DNA deletions in the majority of patients harbouring OPA

82 e-negative fibres and multiple mitochondrial DNA deletions in the muscle of patients with s-IBM have

83 the nutritional supplement Cr(III) increase DNA deletions in vitro and in vivo, when ingested via dr

84 tochondrial protein carbonyls, mitochondrial DNA deletions, increased autophagy and signaling for mit

85 ion, we have introduced an identical genomic DNA deletion into the murine CLN3 homologue (Cln3) to cr

86 creased mitochondrial defects, mitochondrial DNA deletion levels, and susceptibility to such dysfunct

87 s microsatellite) primer pairs and a plastid DNA deletion marker that distinguishes most lowland Chil

88 This high rate of DNA deletion may explain the compact nature of the nemat

89 chromium(III) chloride on the frequencies of DNA deletions measured with the deletion assay in Saccha

90 Large mitochondrial (mt) DNA deletion mutations (4.4-9.7 kb) were detected in all

91 ndrial abnormalities contained mitochondrial DNA deletion mutations as revealed by laser capture micr

92 We hypothesized that mitochondrial DNA deletion mutations contribute to the fiber atrophy a

93 causal role for age-associated mitochondrial DNA deletion mutations in sarcopenia.

94 Site-specific DNA deletion occurs at thousands of sites within the gen

95 When there was no homology with the donor DNA, deletions of up to 5 kb involving direct repeats th

96 ngly activate transcription when targeted to DNA; deletion of this domain generates an allele that ex

97 s to the formation of multiple mitochondrial DNA deletions over time, similar to aging and Parkinson'

98 DNA deletion patients with atypical symptoms have been a

99 The possibility of generating long on-target DNA deletions poses safety risks to somatic genome editi

100 lasma apolipoprotein (apo) A-I can be due to DNA deletions, rearrangements, or nonsense or frameshift

101 basement membrane thickening, mitochondrial DNA deletions, reduction of nerve conduction velocities

102 In all species, we found that DNA deletions relate to genome size similarly as TE leng

103 -/-) mice displayed an elevated frequency of DNA deletions, resulting from HR at the endogenous p(un)

104 ion technique to determine the mitochondrial DNA deletion spectrum of almost the entire mitochondrial

105 eased DNA ligase IIIalpha and a reduction in DNA deletions, suggesting that FLT3 signaling regulates

106 led that Cr(III) is a more potent inducer of DNA deletions than Cr(VI) once Cr(III) is absorbed.

107 mal stripe (NCS) mutants carry mitochondrial DNA deletions that affect subunits of respiratory comple

108 This interference with DNA deletion usually is manifested as a cytoplasmic domi

109 ntrast, in Fancg(-/-) mice, the frequency of DNA deletions was decreased.

110 ients with single, large-scale mitochondrial DNA deletions we demonstrate that a variety of outcome m

111 Multiple mitochondrial DNA deletions were seen by long polymerase chain reactio

112 Multiple mitochondrial DNA deletions were universally present in patients who u

113 legia associated with multiple mitochondrial DNA deletions, whereas recessive SLC25A4 mutations cause

114 DNA deletion within the Ifng-as1 locus disrupted chromat