ライフサイエンスコーパス: DNA glycosylase

1 clease) and DNA repair enzymes (e.g., uracil-DNA glycosylase).

2 but instead depends, in part, on the thymine DNA glycosylase.

3 ranslational modification of the human MutYH DNA glycosylase.

4 effects were observed previously for thymine DNA glycosylase.

5 osphate and from genomic DNA by 8-oxoguanine-DNA glycosylase.

6 sed in a coupled assay in principle with any DNA glycosylase.

7 ue to inactivation of MUTYH, which encodes a DNA glycosylase.

8 utase (MnSOD) and mitochondrial 8-oxoguanine DNA glycosylase.

9 ) base interrogation during lesion search by DNA glycosylases.

10 tic promiscuity, such as these two unrelated DNA glycosylases.

11 ine (G) are substrates for repair by various DNA glycosylases.

12 rent catalytic mechanism from those of other DNA glycosylases.

13 ich are repair intermediates of bifunctional DNA glycosylases.

14 of DNA sliding is human 8-oxoguanine ((o)G) DNA glycosylase 1 (hOGG1), which repairs mutagenic (o)G

15 ing the DNA glycosylase gene 3-MethylAdenine DNA Glycosylase 1 (MAG1), which is part of the base-exci

16 ere recently shown to stimulate 8-oxoguanine DNA glycosylase 1 (OGG1), an enzyme that removes oxidize

17 enzymes, the DNA glycosylases TDG and 8-oxoG DNA glycosylase 1 (OGG1), apurinic/apyrimidinic (AP) end

18 8-Oxoguanine-DNA glycosylase-1 (OGG1) is the primary enzyme for repai

19 8-Oxoguanine DNA glycosylase-1 (OGG1)-initiated base excision repair

20 gulation of TIMP1 expression by 8-oxoguanine DNA glycosylase-1 binding to DNA:RNA hybrid.

21 more pronounced in the case of 8-oxoguanine-DNA-glycosylase-1 and nei-endonuclease-VIII-like.

22 of DNA damage repair molecules 8-oxoguanine-DNA-glycosylase-1, nei-endonuclease-VIII-like, X-ray-rep

23 , we report that the suppression of Nei-like DNA glycosylase 2 (NEIL2), a mammalian DNA glycosylase t

24 n be selectively killed by inhibiting uracil DNA glycosylase 2 (UNG) and that this synthetic lethal p

25 erase 3alpha (TOP3alpha) and NEIL3 (Nei-like DNA glycosylase 3), as well as transcription and RNA reg

26 The major DNA glycosylase, 8-oxoguanine glycosylase (OGG1), is res

27 We examined the role of the viral uracil DNA glycosylase, a protein conserved among all herpesvir

28 PRs in mice lacking the BER-initiating DNA glycosylase AAG did not exhibit alkylation-induced n

29 ide cancer protection similar to that of the DNA glycosylase AAG.

30 e repair of deaminated purines, alkyladenine DNA glycosylase (AAG) and AP endonuclease (APE1).

31 oxyribosyl moiety of DNA, human alkyladenine DNA glycosylase (AAG) and Escherichia coli 3-methyladeni

32 Human alkyladenine DNA glycosylase (AAG) employs nonspecific DNA binding in

33 ision repair (BER) initiated by alkyladenine DNA glycosylase (AAG) is essential for removal of aberra

34 Human alkyladenine DNA glycosylase (AAG) is thought to initiate base excisi

35 In human alkyladenine DNA glycosylase (AAG), the enzyme that initiates base ex

36 ision repair (BER) initiated by alkyladenine DNA glycosylase (AAG).

37 The mouse alkyl adenine DNA glycosylase (AAG, also known as MPG) recognizes such

38 ng RONS-induced DNA damage; the alkyladenine DNA glycosylase (Aag/Mpg) excises several DNA base lesio

39 ve DNA demethylation mediated by the DEMETER DNA glycosylase accounts for all of the demethylation in

40 G/I, T/I, and A/I base pairs and a xanthine DNA glycosylase acting on all double-stranded and single

41 and A/U base pairs, but also a hypoxanthine DNA glycosylase acting on G/I, T/I, and A/I base pairs a

42 through the female lineage due to widespread DNA glycosylase activity in the male germline, and exten

43 /I > C/I, matching the trend of hypoxanthine DNA glycosylase activity observed in vitro.

44 domain of ROS1 is indispensable for the 5mC DNA glycosylase activity of ROS1.

45 f NEIL1 are catalytically inactive for their DNA glycosylase activity, these deficiencies may increas

46 superfamily studied thus far exhibit uracil-DNA glycosylase activity.

47 Using the DNA glycosylase AlkD from Bacillus cereus, we crystallog

48 or quantitative measurements of 8-oxoguanine DNA glycosylase, alkyl-adenine DNA glycosylase, MutY DNA

49 tion of intercalation for human alkyladenine DNA glycosylase, an enzyme that initiates repair of alky

50 d by AID/APOBEC enzymes, here we used uracil-DNA glycosylase and an alkoxyamine to covalently tag and

51 pyAXII) and demonstrated their DNA cleavage, DNA glycosylase and AP lyase activities in vitro at 37 d

52 ed as Zf-GRF repeat) are dispensable for its DNA glycosylase and AP lyase activity; however, the pote

53 the VACV D4 protein serves both as a uracil-DNA glycosylase and as an essential component required f

54 poson-based library construction with uracil DNA glycosylase and endonuclease VIII to specifically de

55 product of 5hmC could be excised by thymine DNA glycosylase and MBD4 glycosylases regardless of cont

56 two additional uracil glycosylases, thymine-DNA glycosylase and SMUG1.

57 n to interact with the 8-oxoguanine (8-oxoG) DNA glycosylase and stimulate its enzymatic activities.

58 terstrand cross-link repair pathways via its DNA glycosylase and/or AP lyase activity, which are cons

59 amages in opposing DNA strands with selected DNA glycosylases and human apurinic/apyrimidinic endonuc

60 Base excision repair (BER) is initiated by DNA glycosylases and is crucial in repairing RONS-induce

61 correlated with active DNA demethylation by DNA glycosylases and repressive targeting by the Polycom

62 vity of several enzymes [four BER-initiating DNA glycosylases and the downstream processing apurinic/

63 was paralleled by a compromised TDG (thymine DNA glycosylase) and TET1 (ten-eleven translocation prot

64 NA glycosylase, MutY DNA glycosylase, uracil DNA glycosylase, and APE1 activity.

65 d 5-HmdU, may be cleaved from DNA by thymine DNA glycosylase, and subsequent action of base-excision

66 7C and G241R was observed on a pre-assembled DNA glycosylase.AP-DNA complex as well.

67 Near the dyad, uracil DNA glycosylase/APE1 removes an outwardly oriented uraci

68 In contrast, DNA glycosylases, apurinic/aprymidinic endonuclease 1 an

69 DNA glycosylases are enzymes that perform the initial st

70 DNA glycosylases are important editing enzymes that prot

71 Previous fluorescence methods for assaying DNA glycosylases are often complex and/or limited in sco

72 e in HD model R6/2 mice indicates that these DNA glycosylases are present in brain areas affected by

73 OS1/DEMETER family of 5-methylcytosine (5mC) DNA glycosylases are the first genetically characterized

74 ost part, only allow for the analysis of one DNA glycosylase at a time.

75 oxidized bases, initiated by NEIL1 and other DNA glycosylases at the chromatin level remains unexplor

76 ion of the base excision repair (BER) enzyme DNA glycosylase augments PD-L1 upregulation in response

77 model nucleosomes following base excision by DNA glycosylases but prior to handover to APEX1.

78 Thymine DNA glycosylase can further remove 5fC and 5caC, connect

79 Also, the NEIL1 and NEIL3 DNA glycosylases can remove hydantoin lesions but none o

80 Levels of BER-initiating DNA glycosylases can vary between individuals, suggestin

81 have described both vertebrate and microbial DNA glycosylases capable of unhooking highly toxic inter

82 DNA glycosylases catalyze the first step of the base exc

83 We show that human methylpurine DNA glycosylase cleaves N-glycosidic bonds on RNA and th

84 In summary, CREB1 and DNA glycosylases compete for damaged CRE in vitro and in

85 DNA glycosylases constitute a biologically and biomedica

86 results suggest that Fpg, and possibly other DNA glycosylases, convert part of the binding energy int

87 Uracil DNA glycosylase could hydrolyze deoxyuracils of the apta

88 tion-associated genes in a Tet3- and thymine DNA glycosylase-dependent fashion in DRG neurons.

89 Why mammalian cells possess multiple DNA glycosylases (DGs) with overlapping substrate ranges

90 lf, the enzyme harbors a helix-hairpin-helix DNA glycosylase domain followed by a unique C-terminal d

91 contains an N-terminal MBD and a C-terminal DNA glycosylase domain.

92 expanded biological utility are specialized DNA glycosylases - enzymes that selectively excise damag

93 amily 6 and designate it as the hypoxanthine-DNA glycosylase family.

94 DNA glycosylases for oxidized bases carry both a glycosy

95 dification sites was developed that utilizes DNA glycosylases found in the base excision repair pathw

96 Formamidopyrimidine-DNA glycosylase (Fpg) excises 8-oxoguanine (oxoG) from D

97 A glycosylase (UDG) and formamido-pyrimidine-DNA glycosylase (FPG), 3'-5' exonucleases, and enzymes w

98 e, by the repair enzyme, formamidopyrimidine-DNA glycosylase (Fpg), likely involves multiple gates.

99 revealed introduction of formamidopyrimidine-DNA glycosylase (Fpg)-sensitive oxidative DNA lesions su

100 xamined the consequences of compromising the DNA glycosylases (Fpg and MutY) and endonucleases (Smx a

101 The family 4 uracil-DNA glycosylase from the hyperthermophilic organism Arch

102 Unlike uracil-DNA glycosylases from diverse sources, where the C termi

103 DEMETER (DME), a DNA glycosylase functioning in the base-excision DNA rep

104 antitative PCRs (qPCRs) targeting the uracil DNA glycosylase gene (udg) or the 23S rRNA gene are desc

105 volved in DNA repair pathways, including the DNA glycosylase gene 3-MethylAdenine DNA Glycosylase 1 (

106 atory circuit centered on a 5-methylcytosine DNA glycosylase gene is required for long-term epigeneti

107 hat targeted inactivation of the mouse Smug1 DNA glycosylase gene is sufficient to ablate nearly all

108 combined with inactivation of the Ung uracil-DNA glycosylase gene leads to a loss of nearly all detec

109 Their processing by the OGG1 and MUTYH DNA glycosylases generates closely spaced incisions on o

110 Human N-methylpurine DNA glycosylase (hMPG) initiates base excision repair of

111 These results reveal how the human oxoG DNA glycosylase hOGG1 locates the lesions inside the DNA

112 the structure of a human 8-oxoguanine (oxoG) DNA glycosylase, hOGG1, in which a normal guanine from D

113 Human DNA glycosylase, hOGG1, is known to perform DNA repair b

114 stal structures of human 8-oxoguanine (oxoG) DNA glycosylase, hOGG1, that interact with the DNA conta

115 The MutY DNA glycosylase homologue (MutYH) recognizes A:8-oxo-G m

116 equence, all three analogs can be cleaved by DNA glycosylases; however, glycosylase activity is block

117 leobase excision activities of human thymine DNA glycosylase (hTDG) toward duplex DNA substrates harb

118 ssay to study damage search by human thymine DNA glycosylase (hTDG), which initiates BER of mutagenic

119 DNA repair enzymes such as human uracil-DNA glycosylase (hUNG) perform the initial step in the b

120 Human uracil DNA glycosylase (hUNG) plays a central role in DNA repai

121 kbone in sliding and hopping by human uracil DNA glycosylase (hUNG), which is an exemplar that effici

122 ell line that had no detectable human uracil DNA glycosylase (hUNG2) activity, establishing that hUNG

123 ed the probability that nuclear human uracil DNA glycosylase (hUNG2) excised two uracil lesions space

124 abasic site recognition, the rate of uracil-DNA glycosylase hydrolysis of the N-glycosidic bond, con

125 responses, whereas a lack of other Nei-like DNA glycosylases (i.e., NEIL1 and NEIL2) had no signific

126 e (AAG) and Escherichia coli 3-methyladenine DNA glycosylase II (AlkA) bind tightly to their abasic D

127 3-Methyladenine DNA glycosylase II (AlkA) is an enzyme that cleaves a wi

128 domain (MBD) family, MBD4 serves as a potent DNA glycosylase in DNA mismatch repair specifically targ

129 regulatory mechanism for the essential MutYH DNA glycosylase in human cells.

130 onal analysis of gene expression profiles of DNA glycosylases in gastric specimens linked the reduced

131 dues are removed from DNA by specific uracil-DNA glycosylases in the base excision repair pathway.

132 breaks caused by base excision from ssDNA by DNA glycosylases, including Nei-like (NEIL) 1, would gen

133 Knockdown of thymine DNA glycosylase increased 5caC in genome, affected cell

134 Coupled with a uracil-DNA glycosylase inhibitor, dCas9-AIDx converted targeted

135 by either replication-dependent dilution or DNA glycosylase-initiated base excision repair.

136 DNA methyltransferases and 5-methylcytosine DNA glycosylases interact to maintain epigenetic homeost

137 ndonuclease VIII-like protein 1 (NEIL1) is a DNA glycosylase involved in initiating the base excision

138 The NEIL3 DNA glycosylase is a base excision repair enzyme that ex

139 The bacterial MutY (MUTYH in humans) adenine DNA glycosylase is able to initiate the repair of A:oxoG

140 MUTYH DNA glycosylase is responsible for recognizing and remov

141 Ogg1 (8-oxoguanine DNA glycosylase) is one such silenced base excision repa

142 fluenced by either UNG1/2, SMUG1, or thymine-DNA glycosylase knockdown, strongly suggesting that ther

143 Bacillus cereus AlkD is the only DNA glycosylase known to catalyze base excision without

144 HDAC1 stimulates OGG1, a DNA glycosylase known to remove 8-oxoG lesions that are

145 Although uracil DNA glycosylases limit APOBEC-induced mutation, it is un

146 eport the functional characterization of the DNA glycosylase/lyase DNG701 in rice.

147 The 5-methylcytosine DNA glycosylase/lyase REPRESSOR OF SILENCING 1 (ROS1)-me

148 ults demonstrate that rice DNG701 is a 5-meC DNA glycosylase/lyase responsible for the demethylation

149 ve DNA demethylation by the 5-methylcytosine DNA glycosylase/lyase ROS1.

150 cing 1 (ROS1) is a multi-domain bifunctional DNA glycosylase/lyase, which excises 5-methylcytosine (5

151 l of eukaryotic and prokaryotic bifunctional DNA glycosylases/lyases (NEIL1, Nei, Fpg, Nth, and NTH1)

152 Here we investigate the bifunctional DNA glycosylases/lyases NEIL1 and NEIL2, which act in re

153 family of genes that encode 5-methylcytosine DNA glycosylases/lyases.

154 along with the base excision repair pathway DNA glycosylase MAG1 renders the tpa1Deltamag1Delta doub

155 By fusing the yeast 3-methyladenine DNA glycosylase MAG1 to a tetR DNA-binding domain, we ar

156 ting the basal and MMS-induced expression of DNA glycosylase Mag1.

157 The NEIL3 DNA glycosylase maintains genome integrity during replic

158 Thus, the NEIL DNA glycosylases may be involved in both telomere mainte

159 Here we present the first, to our knowledge, DNA glycosylase mechanism that does not require base fli

160 The mammalian DNA glycosylase--methyl-CpG binding domain protein 4 (MB

161 ue to inefficient turnover of N-methylpurine-DNA glycosylase (MPG), which initiates BER of epsilonA.

162 Mitochondria-targeted human 8-oxoguanine DNA glycosylase (mt-hOgg1) and aconitase-2 (Aco-2) each

163 Family 2 mismatch-specific uracil DNA glycosylase (MUG) from Escherichia coli is known to

164 of strandwise translocation of 8-oxoguanine DNA glycosylase, MutM, along undamaged DNA.

165 The DNA glycosylase MutY prevents deleterious mutations resu

166 8-oxoguanine DNA glycosylase, alkyl-adenine DNA glycosylase, MutY DNA glycosylase, uracil DNA glycos

167 ditional (fifth) viral gene, encoding uracil-DNA glycosylase (MVADelta5-HIV); or (iii) represent the

168 w the presence of the oxidized base-specific DNA glycosylase Nei-like 2 (NEIL2) and the DNA end-proce

169 we demonstrated that the bacterial and human DNA glycosylases Nei and NEIL1 excise unhooked psoralen-

170 The human DNA glycosylase NEIL1 was recently demonstrated to initi

171 t the DNA base excision repair (BER) enzyme, DNA glycosylase NEIL1, efficiently recognizes and excise

172 Compared with the other DNA glycosylases NEIL1 and NEIL2, Xenopus laevis NEIL3 C

173 e base excision activities of five mammalian DNA glycosylases (NEIL1, NEIL2, mNeil3, NTH1, and OGG1)

174 we observed that the endonuclease VIII-like DNA glycosylase, NEIL1, accumulates at sites of oxidativ

175 that elevated expression of the bifunctional DNA glycosylase, NEIL2, sensitizes breast cancer cells t

176 The DNA glycosylase NEIL3 has been implicated in DNA repair

177 nds forming the cross-link is cleaved by the DNA glycosylase NEIL3.

178 ases in naked DNA, products generated by the DNA glycosylase NTHL1 were efficiently processed by the

179 se lesions in the human genome, initiated by DNA glycosylases, occurs via the base excision repair pa

180 nes, which are recognized and cleaved by two DNA glycosylases of the base excision repair pathway, en

181 cts supplemented with exogenous 8-oxoguanine DNA glycosylase (OGG1) did so.

182 odulating the DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1) in the PyMT transgenic mouse mode

183 Human 8-oxoguanine DNA glycosylase (OGG1) is a key enzyme involved in remov

184 Human 8-oxoguanine-DNA glycosylase (OGG1) plays a major role in the base ex

185 8-Oxoguanine-DNA glycosylase (OGG1) removes premutagenic lesion 8-oxo

186 BER and relies on the upstream 8-oxoguanine-DNA glycosylase (OGG1) to recognise and excise 8-oxoG.

187 g base excision repair (BER) by 8-oxoguanine DNA glycosylase (OGG1), yielding an abasic site (AP).

188 s when not repaired properly by 8-oxoguanine DNA glycosylase (Ogg1).

189 nine (8-oxoG) primarily via the 8-Oxoguanine DNA glycosylase (OGG1).

190 zed by DNA glycosylases such as 8-oxoguanine DNA glycosylase (OGG1).

191 e sugar-phosphate backbone and the action of DNA glycosylases on deaminated, oxidized, and alkylated

192 Uracil DNA glycosylase plays a key role in DNA maintenance via

193 MutM, a bacterial DNA-glycosylase, plays a critical role in maintaining ge

194 Some DNA glycosylases possess AP lyase activities that nick t

195 DNA glycosylases preserve genome integrity and define th

196 DNA glycosylases protect genomic integrity by locating a

197 Thus, NEIL1 and NEIL2 DNA glycosylases protect mitochondrial DNA against oxida

198 n of SMUG1 or thymine-DNA glycosylase uracil-DNA glycosylases, proving that it is base excision by UN

199 y contribute to removal of uracils by uracil DNA glycosylase regardless of the translational or rotat

200 he immunoprecipitate of human NEIL1, a major DNA glycosylase responsible for oxidized base repair.

201 DME encodes a 5-methylcytosine DNA glycosylase responsible for transcriptional derepres

202 The DNA glycosylase ROS1 was only partially decreased in act

203 ed in flowering or DNA repair, including the DNA glycosylase ROS1, which facilitates DNA demethylatio

204 tructures have captured for the first time a DNA glycosylase scanning the genome for a damaged base i

205 ingle-strand selective monofunctional uracil DNA glycosylase (SMUG1).

206 ision repair, a pathway that is catalyzed by DNA glycosylases such as 8-oxoguanine DNA glycosylase (O

207 The uracil DNA glycosylase superfamily consists of several distinct

208 of DNA polymerase B (polB) and methyladenine DNA glycosylase (tag) genes responsible for the repair o

209 5fC and 5caC are excised by mammalian DNA glycosylase TDG, implicating 5mC oxidation in DNA de

210 d dinucleotide and purified BER enzymes, the DNA glycosylases TDG and 8-oxoG DNA glycosylase 1 (OGG1)

211 o regenerate unmodified cytosines by thymine-DNA glycosylase (TDG) and base excision repair (BER) pat

212 that the base excision repair enzyme thymine DNA glycosylase (TDG) could be such a target for its dua

213 modulated in the presence of TET and thymine DNA glycosylase (TDG) enzymes.

214 The mammalian thymine DNA glycosylase (TDG) excises the mismatched base, uraci

215 ylcytosine dioxygenase 2 (TET2), and Thymine DNA glycosylase (TDG) genes.

216 h 5fC and 5caC subject to removal by thymine DNA glycosylase (TDG) in conjunction with base excision

217 ispair, and this step is followed by thymine DNA glycosylase (TDG) initiated base excision repair (BE

218 Thymine DNA glycosylase (TDG) initiates the repair of G.T mismat

219 Thymine DNA Glycosylase (TDG) is a base excision repair enzyme f

220 Thymine DNA glycosylase (TDG) is an essential enzyme playing mul

221 The mammalian thymine DNA glycosylase (TDG) is implicated in active DNA demeth

222 nactivation of the DNA repair enzyme thymine DNA glycosylase (TDG) leads to embryonic lethality in mi

223 Thymine DNA Glycosylase (TDG) performs essential functions in ma

224 n (TET) enzymes (TET1/TET2/TET3) and thymine DNA glycosylase (TDG) play crucial roles in early embryo

225 Thymine-DNA glycosylase (TDG) plays critical roles in DNA base e

226 l of DNA demethylases, we found that thymine DNA glycosylase (TDG) up-regulated Wnt signaling.

227 ship between chromatin structure and thymine DNA glycosylase (TDG) using chemically defined nucleosom

228 sine (caC), excision of fC or caC by thymine DNA glycosylase (TDG), and restoration of cytosine via f

229 sine (caC), excision of fC or caC by thymine DNA glycosylase (TDG), and subsequent base excision repa

230 electively recognized and excised by thymine DNA glycosylase (TDG), leading to DNA demethylation.

231 are recognized by the monofunctional thymine DNA glycosylase (Tdg), which cleaves the glycosidic bond

232 A key player is thymine DNA glycosylase (TDG), which excises thymine from mutage

233 Many TET2- and thymine-DNA glycosylase (TDG)-dependent 5mC and 5hmC changes dir

234 by replication-dependent dilution or thymine DNA glycosylase (TDG)-dependent base excision repair.

235 sine through iterative oxidation and thymine DNA glycosylase (TDG)-mediated base excision repair.

236 gulatory proteins, including p53 and thymine DNA glycosylase (TDG).

237 e (5fC)/5-carboxylcytosine (5caC) by thymine DNA glycosylase (TDG).

238 es and excision of oxidized bases by thymine DNA glycosylase (TDG).

239 hemselves contribute to AML, such as thymine DNA glycosylase (TDG).

240 thymine from G.T mispairs, including thymine DNA glycosylase (TDG).

241 ied as a function of (i) the lesion type and DNA glycosylase tested, (ii) local sequence context and

242 Family 4 UDGa is a robust uracil DNA glycosylase that only acts on double-stranded and si

243 hachiroi AlkZ (previously Orf1), a bacterial DNA glycosylase that protects its host by excising ICLs

244 Endonuclease VIII-like 1 (NEIL1) is a DNA glycosylase that recognizes a broad range of oxidati

245 MutM is a bacterial DNA glycosylase that serves as the first line of defense

246 -like DNA glycosylase 2 (NEIL2), a mammalian DNA glycosylase that specifically removes oxidized bases

247 NEIL1 is one of the 11 human DNA glycosylases that catalyze the first step of the BER

248 e structural and mechanistic features of the DNA glycosylases that enable these functions.

249 )-like protein 1], one of the five mammalian DNA glycosylases that excise oxidized DNA base lesions i

250 uble-stranded (ds)DNA scanning enzymes, e.g. DNA glycosylases that excise rare aberrant bases, there

251 AP sites are also generated by DNA glycosylases that initiate DNA base excision repair.

252 e monophosphate, or that lack MutM and MutY, DNA glycosylases that process base pairs involving 8-oxo

253 xcision repair (BER), a process initiated by DNA glycosylases that recognize and remove damaged DNA b

254 Base excision repair is initiated by DNA glycosylases that recognize specific altered bases.

255 ducts of this or any type are not excised by DNA glycosylases that use a traditional base-flipping me

256 The abilities of the DNA glycosylases to incise the DNA strand adjacent to G*

257 is critically dependent upon the ability of DNA glycosylases to locate rare sites of damage embedded

258 ILENCING 1 (ROS1) family of 5-methylcytosine DNA glycosylases to protect these genes from silencing.

259 The ability of DNA glycosylases to rapidly and efficiently detect lesio

260 rable interest surrounds the question of how DNA glycosylases translocate efficiently along DNA while

261 ylation in plants is mediated by a family of DNA glycosylases typified by Arabidopsis ROS1 (repressor

262 ioned 2'-deoxyuridine (dU) residue by uracil DNA glycosylase (UDG) and apurinic/apyrimidinic endonucl

263 eotide kinase, the DNA repair enzymes uracil-DNA glycosylase (UDG) and formamido-pyrimidine-DNA glyco

264 Enzymes like uracil DNA glycosylase (UDG) can achieve ground state destabili

265 Uracil-DNA glycosylase (UDG) compromises the replication strate

266 ivity of both bacterial and mammalian uracil-DNA glycosylase (UDG) enzymes.

267 Enzymes in Uracil DNA glycosylase (UDG) superfamily are essential for the

268 UDGb belongs to family 5 of the uracil DNA glycosylase (UDG) superfamily.

269 pair enzymes, in particular by MutM and MutY DNA glycosylases, ultimately contributes to cell death.

270 d cytidine deaminase are processed by uracil-DNA glycosylase (UNG) and mismatch repair (MMR) pathways

271 ion repair (BER), either initiated by uracil-DNA glycosylase (UNG) or by single-strand selective mono

272 the Ig gene loci can be recognized by uracil DNA glycosylase (UNG) or mutS homologs 2 and 6 (MSH2-MSH

273 plementary pathways, initiated by the uracil-DNA glycosylase (UNG) or the mismatch repair factor MSH2

274 We show that depletion of the uracil DNA glycosylase (UNG) sensitizes tumor cells to FdUrd.

275 In this study, the activity of uracil-DNA glycosylase (UNG) was successfully detected and quan

276 Processing of dUs by uracil DNA glycosylase (UNG) yields abasic sites, which are exc

277 We investigated the enzyme uracil-DNA glycosylase (UNG), which detects and cleaves uracil

278 l-guanine mismatches are processed by uracil DNA glycosylase (UNG)-mediated base-excision repair and

279 ation depends on protective repair by uracil-DNA glycosylase (UNG).

280 n enzymatic activity, D4 is an active uracil-DNA glycosylase (UNG).

281 rom DNA is accomplished by the enzyme uracil DNA glycosylase (UNG).

282 9 nickase, a cytidine deaminase and a uracil-DNA glycosylase (Ung).

283 Uracil DNA glycosylases (UNG) are highly conserved proteins tha

284 ions with base excision repair enzyme uracil DNA glycosylase (UNG2) and crossover junction endonuclea

285 on repair pathway by antagonizing the uracil DNA glycosylase (Ung2) enzyme.

286 Uracil DNA Glycosylase (UNG2) is the primary enzyme in humans t

287 to the recruitment of another target, uracil DNA glycosylase (UNG2), to the CRL4-DCAF1 E3 by Vpr.

288 In conclusion, the Nei-like DNA glycosylases unhook psoralen-derived ICLs in various

289 1/2 but not by knockdown of SMUG1 or thymine-DNA glycosylase uracil-DNA glycosylases, proving that it

290 osylase, alkyl-adenine DNA glycosylase, MutY DNA glycosylase, uracil DNA glycosylase, and APE1 activi

291 e findings support a general mechanism where DNA glycosylases use highly dynamic multidimensional dif

292 hat are commonly employed for studying other DNA glycosylases, we observe an unusual biphasic protein

293 We found that DNA glycosylases were efficiently recruited to DNA damag

294 Repair of A:oxoG is initiated by adenine DNA glycosylase, which catalyzes hydrolytic cleavage of

295 w that cells defective in the N-methylpurine DNA glycosylase, which fail to remove N-methylpurines fr

296 fferent DNA repair pathways, including NEIL1 DNA glycosylase, which initiates base excision repair (B

297 ity arising from DNA damage are mitigated by DNA glycosylases, which initiate the base excision repai

298 e specific sites in nucleic acids, including DNA glycosylases, which remove modified nucleobases to i

299 coli endonuclease III (Endo III or Nth) is a DNA glycosylase with a broad substrate specificity for o

300 two model enzymes, exonuclease I and uracil DNA glycosylase with high sensitivity and selectivity.