ライフサイエンスコーパス: DNA helicase

1 m2-7 hexamer forms the core of a replicative DNA helicase.

2 lisomes assemble around the activated Mcm2-7 DNA helicase.

3 is 100-fold better RNA:DNA helicase than DNA:DNA helicase.

4 nomous ATPase, 3'-to-5' translocase, and RNA:DNA helicase.

5 licase-DNA polymerase complex by stabilizing DNA helicase.

6 is a nucleus-encoded human mitochondrial (mt)DNA helicase.

7 mplex) is required for the activation of the DNA helicase.

8 tified six mutations in rqh1 encoding a RecQ DNA helicase.

9 and conformation of the human mitochondrial DNA helicase.

10 oteins that arise in the absence of the Sgs1 DNA helicase.

11 they are inviable in the absence of the Sgs1 DNA helicase.

12 756 amino acids) is also a highly processive DNA helicase.

13 ations in the gene encoding the Werner (WRN) DNA helicase.

14 ein required for loading the replicative MCM DNA helicase.

15 nded DNA tail provides a loading site for T7 DNA helicase.

16 dependent ATPase and a Ku-dependent 3' to 5' DNA helicase.

17 nwind the replication origin, oriC, and load DNA helicase.

18 pin element within the Escherichia coli PriA DNA helicase.

19 nstrated that it is an ATP-dependent RNA and DNA helicase.

20 /G4 regions and supports the binding of Pif1 DNA helicase.

21 hexamers (DH) that serve as the replicative DNA helicase.

22 a member of the SF2 family of ATP-dependent DNA helicases.

23 and FANCJ genes, respectively, which encode DNA helicases.

24 SIV contains conserved motifs of NTPases and DNA helicases.

25 n in yeast and are considered to function as DNA helicases.

26 srs2, which encode known anti-recombinogenic DNA helicases.

27 The F-box DNA helicase 1 (FBH1) is a 3'-5' DNA helicase with a put

28 The RecG DNA helicase a key player in stalled replication fork re

29 ultifunctional Saccharomyces cerevisiae Pif1 DNA helicase, a potent unwinder of G4 structures in vitr

30 RecQ DNA helicases act in conjunction with heterologous partn

31 tem of bacteriophage T7 both DNA primase and DNA helicase activities are contained within a single pr

32 5 protein that has both ubiquitin ligase and DNA helicase activities.

33 a function of MCM proteins apart from their DNA helicase activity and establish a direct link betwee

34 both purified recombinant proteins abolished DNA helicase activity and failed to disrupt the DNA-prot

35 Rim1 stimulated Pif1 DNA helicase activity by 4- to 5-fold, whereas Rim1Delta

36 ukaryotes such as Drosophila, MCM-associated DNA helicase activity has been observed only in the cont

37 e substitutions also diminish SSB-stimulated DNA helicase activity in the variants, although addition

38 We demonstrate an RNA-DNA helicase activity in UAP56 and show that its overexp

39 locate along ssDNA rapidly and processively, DNA helicase activity in vitro requires a minimum of a U

40 er of Atf1 requires an intact F box, but not DNA helicase activity of Fbh1.

41 esults shown in the literature regarding the DNA helicase activity of RecQ4.

42 CMG complex, like the hCMG complex, contains DNA helicase activity that is more salt-resistant than t

43 TPase activity and ATP- and Mg(2+)-dependent DNA helicase activity with a 3' --> 5' polarity.

44 trate that UvrD assembly state regulates its DNA helicase activity with functional implications for i

45 that P56 inhibited HPV type 18 (HPV18) E1's DNA helicase activity, E2 binding, and HPV Ori sequence-

46 Besides its DNA helicase activity, ScPif1 is also known as a single-

47 s included analysis of DNA binding affinity, DNA helicase activity, the kinetics of nucleotide hydrol

48 Interestingly Psp68 also shows the unique DNA helicase activity, which is bipolar in nature (unwin

49 TP hydrolysis activity that is essential for DNA helicase activity.

50 revious reports, we show that RECQ4 exhibits DNA helicase activity.

51 ptide RM enzyme comprising Mrr endonuclease, DNA helicase, adenine methyltransferase and target-recog

52 stic of an mrr endonuclease, a superfamily 2 DNA helicase and a gamma-family adenine methyltransferas

53 equires the dynamic interactions between the DNA helicase and an accessory protein.

54 from its G1 to its G2 mode by blocking Srs2 DNA helicase and Casein Kinase 1 (Hhp1).

55 cattering analysis, that the complex between DNA helicase and DNA polymerase/trx is far more compact

56 This new sub-pathway is mediated by RECQ1 DNA helicase and ERCC1-XPF endonuclease in cooperation w

57 ) complex is the core component of mammalian DNA helicase and has been implicated in replication chec

58 FANCJ, a DNA helicase and interacting partner of the tumor suppre

59 The Sgs1 DNA helicase and its mammalian homolog BLM control cross

60 of helicase-like transcription factor (HLTF) DNA helicase and other DNA repair pathway targets, and b

61 orks at protein fork blocks, the coupling of DNA helicase and polymerase functions during replication

62 DNA helicase and primase are essential for DNA replicati

63 Pif1p, a DNA helicase and Rad53p target, underwent Rad53p-depende

64 m values of Psp68 are 1.6129 and 1.14 nM for DNA helicase and RNA helicase, respectively.

65 Escherichia coli UvrD is a superfamily 1 DNA helicase and single-stranded DNA (ssDNA) translocase

66 rate that Pol IV interacts in vitro with Rep DNA helicase and that this interaction enhances Rep's he

67 -strand polymerase still associated with the DNA helicase and the lagging-strand polymerase that are

68 redundant pathways consisting of nucleases, DNA helicases and associated proteins.

69 he assay makes it applicable to a variety of DNA helicases and DNA templates.

70 s catalyzed by the coordinated activities of DNA helicases and nucleases.

71 in vertebrates requires multiple specialized DNA helicases and polymerases to prevent genetic and epi

72 and DNA polymerase from the replication fork DNA helicase, and 2) on the damaged template, nascent le

73 subunits, that it is a rapid and processive DNA helicase, and that it catalyses DNA unwinding using

74 encodes a member of the RecQ family of 3'-5' DNA helicases, and is proposed to function in recombinat

75 ressed Aae MutL and the putative A. aeolicus DNA helicase (Aq793) proteins in E. coli.

76 se RNA processing factors, including the RNA/DNA helicases Aquarius (AQR) and Senataxin (SETX), or by

77 DNA polymerase and DNA helicase are essential components of DNA replication

78 DNA helicases are at the forefront of such processes, ye

79 DNA helicases are ATP-driven motor proteins that unwind

80 RecQ-like DNA helicases are conserved from bacteria to humans.

81 DNA helicases are directly responsible for catalytically

82 It has been conventionally thought that DNA helicases are inhibited by bulky covalent DNA adduct

83 Replicative DNA helicases are loaded around origins of DNA replicati

84 DNA helicases are motor proteins that catalyze the unwin

85 DNA helicases are motor proteins that couple the chemica

86 DNA helicases are motor proteins that unwind double-stra

87 Bacterial DNA helicases are nucleic acid-dependent NTPases that pl

88 t representative human RecQ and Fe-S cluster DNA helicases are potently blocked by a protein-DNA inte

89 l decline in old HSCs, and highlight the MCM DNA helicase as a potential molecular target for rejuven

90 CM3, an essential subunit of the replicative DNA helicase, as a new substrate.

91 nd was previously thought to link the Mcm2-7 DNA helicase at replication forks to DNA polymerase alph

92 Human DNA helicase B (HELB or HDHB) has been implicated in chr

93 RECQ5 DNA helicase binds to RNA-polymerase (RNAP) II during tr

94 habditis elegans ortholog of the RecQ family DNA helicase BLM, functions in both of these processes.

95 isorder caused by mutations in the RecQ-like DNA helicase BLM, which functions in the maintenance of

96 N helicase activity but did not affect other DNA helicases [Bloom syndrome (BLM), Fanconi anemia grou

97 by their binding partners; one example is a DNA helicase capable of modulating the directionality of

98 re we show that BIR requires the replicative DNA helicase (Cdc45, the GINS, and Mcm2-7 proteins) as w

99 We previously showed that the cellular DNA helicase ChlR1 is required for loading of the bovine

100 irus 16 (HPV16), associate with the cellular DNA helicase ChlR1.

101 In the case of many DNA helicases, closure of the ATP-binding pocket is regu

102 DPC proteolysis is blocked, the replicative DNA helicase CMG (CDC45, MCM2-7, GINS), which travels on

103 osslink, TRAIP ubiquitylates the replicative DNA helicase CMG (the complex of CDC45, MCM2-7 and GINS)

104 e excessive DNA unwinding by the replicative DNA helicase, CMG, demonstrating that budding yeast repl

105 The eukaryotic replicative DNA helicase, CMG, unwinds DNA by an unknown mechanism.

106 The regulated loading of the Mcm2-7 DNA helicase (comprising six related subunits, Mcm2 to M

107 HEL308 is a superfamily II DNA helicase, conserved from archaea through to humans.

108 Here, we report that RECQL4 DNA helicase, deficient in the cancer-prone and prematur

109 DNA-dependent ATPase activity and is a 3'-5' DNA helicase dependent on hydrolysis of ATP.

110 leoplasm, where it co-localizes with the RNA/DNA helicase Dhx9 and paraspeckles; as well as GW/P-bodi

111 hese, 2 independent shRNAs targeting the RNA/DNA helicase Dhx9 were found to sensitize lymphomas to A

112 by the thymine glycol damage, whereas other DNA helicases (DinG, DnaB, and UvrD) are not significant

113 volutionarily related cores of other RNA and DNA helicases diverged to use different mechanisms.

114 to ssDNA and contributes to formation of the DNA helicase-DNA polymerase complex by stabilizing DNA h

115 first structural model of a bacteriophage T7 DNA helicase-DNA polymerase complex using a combination

116 ue to changes in interaction with the host's DNA helicase DnaB.

117 rom these two organisms, only the homologous DNA helicase (DnaB(BA)) acted as a positive effector of

118 duplex DNA is carried out by the replicative DNA helicase (DnaB) that couples NTP hydrolysis to 5' to

119 egrity of the MCM2-7 hexamer complex and the DNA helicase domain in MCM5 are essential for the proces

120 The DNA helicase domain of DDX11 is essential for sister chr

121 E2 recruits the viral DNA helicase E1 to the origin.

122 d the ability to bind and localize the viral DNA helicase E1 to the viral origin.

123 The DNA helicase encoded by gene 4 of bacteriophage T7 assem

124 The DNA helicase encoded by gene 4 of bacteriophage T7 forms

125 st helicases use ATP in these processes, the DNA helicase encoded by gene 4 of bacteriophage T7 uses

126 s methodology was applied to visualize human DNA helicase F-box-containing DNA helicase (FBH1) acting

127 The RecQ-like DNA helicase family is essential for the maintenance of

128 icase is the prototypical member of the Pif1 DNA helicase family, which is conserved from bacteria to

129 BRCA1 and the DNA helicase FANCJ (also known as BACH1 or BRIP1) have c

130 n of the BRCA1 and Fanconi anemia-associated DNA helicase FANCJ to sites of UV-induced damage.

131 The F-box DNA helicase Fbh1 constrains homologous recombination in

132 isualize human DNA helicase F-box-containing DNA helicase (FBH1) acting on the DNA structures resembl

133 of the complex consisting of six domains of DNA helicase, five domains of RNA primase, two DNA polym

134 We also identified the FANCM-related DNA helicase Fml1 as a potential suppressor of IFSA.

135 In fission yeast, the DNA helicase Fml1, which is an orthologue of human FANCM

136 Mus81, and is countered by the FANCM-related DNA helicase Fml1.

137 HELQ is a superfamily 2 DNA helicase found in archaea and metazoans.

138 A gene encoding a putative DNA helicase from Staphylococcus aureus USA300 was clone

139 While much is known about hexameric DNA helicases from superfamily 3, the papillomavirus E1

140 asure long-range DNA unwinding of individual DNA helicases from the archaeons Methanothermobacter the

141 nisms, including a detailed understanding of DNA helicase function and synaptonemal complex structure

142 The Dna2 ATP-driven 5' to 3' DNA helicase function promotes motion of Dna2 on the fla

143 an Bloom's syndrome helicase BLM, is a yeast DNA helicase functioning in DNA replication and repair.

144 Escherichia coli UvrD DNA helicase functions in several DNA repair processes.

145 The ybiB gene forms an operon with the DNA helicase gene dinG and is under LexA control, being

146 Replicative DNA helicases generally unwind DNA as a single hexamer t

147 DDX11, a super-family 2 iron-sulfur cluster DNA helicase genetically linked to the chromosomal insta

148 The highly conserved RecQ family of DNA helicases has multiple roles in the maintenance of g

149 DNA helicases have important roles in genome maintenance

150 DNA helicases have risen to the forefront as genome care

151 ons in RECQ4, a member of the RecQ family of DNA helicases, have been linked to the progeroid disease

152 polymerase QDE-1, the Werner and Bloom RecQ DNA helicase homologue QDE-3 and dicers.

153 Purification of FBH1, a UvrD DNA helicase, identified a physical interaction with rep

154 UvrD (DNA helicase II) has been implicated in DNA replication,

155 FANCJ encodes a Q motif DEAH box DNA helicase implicated in Fanconi anemia and breast can

156 FANCJ encodes a DNA helicase implicated in homologous recombination (HR)

157 Senataxin (SETX) is an RNA/DNA helicase implicated in transcription termination and

158 n helicase 1 (RTEL1) gene that encodes for a DNA helicase important in telomere maintenance and genom

159 these DNA transactions are promoted by RECQ5 DNA helicase in a manner dependent on its Ser727 phospho

160 es helicase-like transcription factor (HLTF) DNA helicase in a proteasome-dependent manner by redirec

161 s highlighted a role for Smc5/6 and the Sgs1 DNA helicase in preventing the accumulation of unresolve

162 process is the activation of the replicative DNA helicase in situ at each origin of DNA replication.

163 onhydrolyzable ATP analog), contains maximal DNA helicase in the presence of forked DNA structures, a

164 versely, accumulating evidence suggests that DNA helicases in cancer cells have a network of pathway

165 We discuss the roles of RECQ DNA helicases in cancer, emphasizing some of the more re

166 aspects of DNA replication; the activity of DNA helicase increases and the sensitivity of DNA polyme

167 nding by XPD helicase, a Superfamily 2 (SF2) DNA helicase involved in DNA repair and transcription in

168 nterstrand crosslink repair, FANCJ encodes a DNA helicase involved in recombinational repair and repl

169 nteraction between TopBP1 and BACH1/FANCJ, a DNA helicase involved in the repair of DNA crosslinks.

170 The conserved RECQ5 DNA helicase is a tumor suppressor in mammalian cells.

171 The metazoan mitochondrial DNA helicase is an integral part of the minimal mitochon

172 In E. coli, the DNA helicase is DnaB and DnaC is its loading partner.

173 hesis, but it has remained unclear whether a DNA helicase is involved in this reaction.

174 The FANCJ DNA helicase is linked to hereditary breast and ovarian

175 he low salt sensitivity of the mitochondrial DNA helicase is mitigated by the presence of magnesium,

176 A component of the replicative DNA helicase is phosphorylated within the replisome in a

177 A good candidate DNA helicase is Pif1, an evolutionarily conserved helica

178 Activation of the Mcm2-7 replicative DNA helicase is the committed step in eukaryotic DNA rep

179 The oligomeric state of Superfamily I DNA helicases is the subject of considerable and ongoing

180 he Q motif, conserved in a number of RNA and DNA helicases, is proposed to be important for ATP bindi

181 omplex is a key component of the replicative DNA helicase, its association with Cdc45 and GINS (the C

182 : MPE, a DNA endonuclease; Lhr-Core, a 3'-5' DNA helicase; LIG, an ATP-dependent DNA ligase; and Exo,

183 f defects in the related human mitochondrial DNA helicase may be responsible for inefficient DNA repl

184 ensing and signaling; the cellular pool of a DNA helicase may contain subpopulations of enzymes carry

185 rtnerships between RPA and interacting human DNA helicases may greatly enhance their ability to dislo

186 stressed by dNTP depletion, the replicative DNA helicase, MCM, and the leading-strand DNA polymerase

187 e licensed by the loading of the replicative DNA helicase, Mcm2-7, in inactive double hexameric form

188 e licensed by the loading of the replicative DNA helicase, Mcm2-7.

189 Conserved, multitasking DNA helicases mediate diverse DNA transactions and are r

190 However, the processivity of the DNA helicase might overcome DNA gyrase and topoisomerase

191 e of cofactors and renders the mitochondrial DNA helicase more susceptible to proteolytic digestion.

192 A DNA helicase moves the DNA through the nanopore in discr

193 h in budding yeast shows that removal of the DNA helicase Mph1 improves survival of cells with defect

194 In budding yeast the DNA helicase Mph1 prevents genome rearrangements during

195 g yeast Smc5/6 complex directly binds to the DNA helicase Mph1.

196 BLM, a RecQ family DNA helicase mutated in Bloom's Syndrome, participates i

197 Mycobacterial AdnAB is a heterodimeric DNA helicase-nuclease and 3' to 5' DNA translocase impli

198 ly linked to mutations in WRN that encodes a DNA helicase-nuclease believed to operate at stalled rep

199 bacillus stearothermophilus Bad, a bacterial DNA helicase-nuclease with similarity to human DNA2.

200 Escherichia coli RecBCD is a DNA helicase/nuclease that functions in double-stranded

201 y contrast, large T antigen, the replicative DNA helicase of the simian virus 40 (SV40), is reported

202 We are interested in the DNA helicases of Mycobacteria, a genus of the phylum Act

203 DNA helicases of the RecQ family are conserved among the

204 The translocation of DNA helicases on single-stranded DNA and the unwinding o

205 n DNA replication, but not its activity as a DNA helicase or its ability to bind to ssDNA.

206 In bacteriophage T7, movement of either the DNA helicase or the DNA polymerase alone terminates upon

207 omplex family; or encode CDC7, HAS2, DNA2 (a DNA helicase), or RPA2 (a protein that binds single-stra

208 The Escherichia coli RecQ DNA helicase participates in a pathway of DNA repair tha

209 rate constants have been determined for the DNA helicase PcrA ATPase cycle when bound to either sing

210 The essential DNA helicase, PcrA, regulates recombination by displacin

211 Here we show that the Pif1 family DNA helicase Pfh1 plays a dual role in promoting replica

212 The Pif1 DNA helicase, Pfh1, promotes efficient restart and also

213 haromyces pombe encodes a single Pif1 family DNA helicase, Pfh1.

214 Overexpressing the G4-DNA helicase Pif1 in neurons exposed to the G4 stabilize

215 ock occurs only in the presence of the 5'-3' DNA helicase Pif1.

216 haromyces cerevisiae encodes two Pif1 family DNA helicases, Pif1 and Rrm3.

217 nding protein family, PABPC5, and of the RNA/DNA helicase PIF1alpha.

218 ocus quantification also indicates that RecQ DNA helicase plays dual roles in promoting repair HJs an

219 s minichromosome maintenance (MCM) 3' --> 5' DNA helicase, PolB, replication factor C, and proliferat

220 T7 DNA helicase preferentially utilizes dTTP to unwind dupl

221 f stalled DNA replication forks requires the DNA helicase PriA.

222 We showed that the Pif1 and Rrm3 DNA helicases promote efficient fork convergence and com

223 NCJ, one of 13 genes linked to FA, encodes a DNA helicase proposed to operate in homologous recombina

224 We propose that DDX11 is a DNA helicase protecting against G4 induced double-strand

225 In biochemical assays, polyamides inhibit DNA helicases, providing a plausible mechanism for S-pha

226 otein displacement is also observed with the DNA helicase RECQ1, suggesting a conserved functional in

227 ies on ISG15 functional interaction with the DNA helicase RECQ1, which promotes restart of stalled re

228 ist in Arabidopsis, defined by ATP-dependent DNA Helicase RECQ4A, MMS and UV-sensitive protein81, REV

229 s it acts independently of the ATP-dependent DNA helicase RECQ4A.

230 Mutations within the gene encoding the DNA helicase RECQL4 underlie the autosomal recessive can

231 In humans, mutations in the DNA helicase Regulator of Telomere Elongation Helicase1

232 arkably, trypanosomes have six mitochondrial DNA helicases related to yeast PIF1 helicase.

233 , encoding the orthologue of the human FANCM DNA helicase, rescues the DNA damage sensitivity of smc5

234 90s with reports that some well-known duplex DNA helicases resolved these structures in vitro.

235 ed by biallelic disruption of the WRN or BLM DNA helicases respectively.

236 helicase/translocase Fml1 and the RecQ-type DNA helicase Rqh1 to limit hybrid DNA formation and prom

237 Additionally, the DNA helicases Rqh1 and Fml1 shape recombination frequenc

238 The DNA helicase Rrm3 promotes replication fork progression

239 The DNA helicase RTEL1 facilitates bypass, apparently by gen

240 The RNA/DNA helicase senataxin (SETX) is one of the best charact

241 Leading the replisome, a DNA helicase separates the parental strands that are to

242 or by combined activities of the RecQ family DNA helicase Sgs1 and the helicase/endonuclease Dna2.

243 DNA repair proteins, Rad6 and Rad5, and the DNA helicase Sgs1.

244 tudies indicate that the human mitochondrial DNA helicase shares basic properties with the SF4 replic

245 s for recruitment of the anti-recombinogenic DNA helicase Srs2.

246 1 Anchor region, directly interacts with the DNA helicase subunit XPD/Rad3 in native TFIIH and is req

247 Lhr-(1-856) is 100-fold better RNA:DNA helicase than DNA:DNA helicase.

248 of telomere length 1 (RTEL1) is an essential DNA helicase that disassembles telomere loops (T loops)

249 IH as a heterodimer with the Ssl2 subunit, a DNA helicase that drives promoter melting for the initia

250 The BLM gene mutated in BS encodes a DNA helicase that functions in a protein complex to supp

251 drome (WABS) is caused by defective DDX11, a DNA helicase that is essential for chromatid cohesion.

252 C virus is a 3'-to-5' superfamily 2 RNA and DNA helicase that is essential for the replication of he

253 FANCJ is a DNA helicase that is genetically linked to Fanconi anemi

254 m Deinococcus radiodurans is a superfamily 1 DNA helicase that is homologous to the Escherichia coli

255 MCM proteins are components of a DNA helicase that plays an essential role in DNA replica

256 e Pif1 (ScPif1) is known as an ATP-dependent DNA helicase that plays critical roles in a number of im

257 reen mutant 2) gene encodes an ATP-dependent DNA helicase that regulates homologous recombination in

258 ghnut-shaped homohexameric ATP-dependent RNA-DNA helicase that releases newly synthesized RNA molecul

259 2) identify UAP56 as a cotranscriptional RNA-DNA helicase that unwinds R loops.

260 RecQ family of proteins are highly conserved DNA helicases that have important functions in the maint

261 BLM, encodes a member of the RecQ family of DNA helicases that is needed to suppress genome instabil

262 ding mechanism may be a universal feature of DNA helicases that move along DNA phosphodiester backbon

263 Activation of the eukaryotic replicative DNA helicase, the Mcm2-7 complex, requires phosphorylati

264 used by defects in senataxin, a putative RNA/DNA helicase thought to be involved in the termination o

265 It is the only known DNA helicase to contain an F-box, suggesting that one of

266 Ctf4 protein links the Cdc45-MCM-GINS (CMG) DNA helicase to DNA polymerase alpha (Pol alpha) within

267 at eukaryotic replication forks connects the DNA helicase to DNA polymerases and many other factors.

268 methylase ALKBH3 functions in complex with a DNA helicase to eliminate N3-methylcytosine lesions from

269 (NTD) of DnaB to impair the ability of this DNA helicase to interact with primase.

270 protein FANCD2 acts in opposition to the BLM DNA helicase to restrain telomere replication and recomb

271 DNA primase facilitates binding of DNA helicase to ssDNA and contributes to formation of th

272 Addition of CHK1i re-activates the DNA helicase to unwind DNA, but in the absence of dNTPs,

273 cally melted DNA is required for replicative DNA helicases to initiate unwinding.

274 e MCM2-7 ATPase, the core of the replicative DNA helicase, to origins.

275 strongly biases the unwinding efficiency of DNA helicases toward substrates that bear highly dynamic

276 r role in antagonizing both the FANCM-family DNA helicase/translocase Fml1 and the RecQ-type DNA heli

277 Escherichia coli UvrD is an SF1A DNA helicase/translocase that functions in chromosomal D

278 mutant of the homologous human mitochondrial DNA helicase Twinkle, which is linked to diseases such a

279 DNA helicases use energy derived from nucleoside 5'-trip

280 e coordinated activity of DNA polymerase and DNA helicase, whereas synthesis of the lagging strand in

281 ations in the WRN gene that encodes the RecQ DNA helicase which is critical for maintaining genomic s

282 A crystal structure of the PriA SF2 DNA helicase, which governs restart of prematurely termi

283 sential activity is orchestrated by the PriA DNA helicase, which identifies replication forks via str

284 lication origins of the CMG (Cdc45-MCM-GINS) DNA helicase, which is essential for the progression of

285 Mcm2-7 forms the core of the replicative DNA helicase, which is inactive in the pre-RC.

286 Disassembly of the Cdc45-MCM-GINS (CMG) DNA helicase, which unwinds the parental DNA duplex at e

287 ion and the expression levels of replicative DNA helicases, which ensure maintenance of proliferative

288 case (BLM) is a member of the RecQ family of DNA helicases, which play key roles in the maintenance o

289 the largest subunit of ASCC, encodes a 3'-5' DNA helicase, whose activity is crucial for the generati

290 The F-box DNA helicase 1 (FBH1) is a 3'-5' DNA helicase with a putative function as a negative regu

291 dinates the Cdc45-MCM-GINS (CMG) replicative DNA helicase with DNA polymerases alpha, delta, and epsi

292 cherichia coli RecBC, a rapid and processive DNA helicase with only a single ATPase motor (RecB), pos

293 Mammalian HELQ is a 3'-5' DNA helicase with strand displacement activity.

294 find that Shu1 and Srs2, an anti-recombinase DNA helicase with which the Shu complex physically inter

295 icase and the founding member of a family of DNA helicases with iron-sulphur cluster domains.

296 The RecQ DNA helicase WRN is a synthetic lethal target for cancer

297 Loss of the RecQ DNA helicase WRN protein causes Werner syndrome, in whic

298 nd RNA interference, and found that the RecQ DNA helicase WRN was selectively essential in MSI models

299 TFIIH consists of a core that includes the DNA helicase Xeroderma pigmentosum B (XPB) and a kinase

300 The DNA helicase XPB plays a key role in DNA opening and coo