ライフサイエンスコーパス: DNA mismatch repair

1 latter tumors showed hallmarks of defects in DNA mismatch repair.

2 e-can shorten or lengthen due to a defect in DNA mismatch repair.

3 endometrial and other cancers with defective DNA mismatch repair.

4 mp in the different steps of methyl-directed DNA mismatch repair.

5 Small looped mispairs are corrected by DNA mismatch repair.

6 cancer (HNPCC) is associated with defects in DNA mismatch repair.

7 trains with mutations in genes implicated in DNA mismatch repair.

8 tability (MSI), which results from deficient DNA mismatch repair.

9 lteration frequency is entirely dependent on DNA mismatch repair.

10 the context-dependence of the efficiency of DNA mismatch repair.

11 , suggesting a role for Dam in H. influenzae DNA mismatch repair.

12 pha heterodimer that is normally involved in DNA mismatch repair.

13 has been implicated in the excision step of DNA mismatch repair.

14 ding cells with adequate metabolites for the DNA mismatch repair.

15 ease activity of MutL and it is critical for DNA mismatch repair.

16 in defective in Pol epsilon proofreading and DNA mismatch repair.

17 ms2, is the major MutL activity in mammalian DNA mismatch repair.

18 ladder, and head and neck tumors with intact DNA mismatch repair.

19 extracts deficient in BLM were competent for DNA mismatch repair.

20 egregation of chromosomes or inactivation of DNA mismatch repair.

21 e sequences in the genome caused by impaired DNA mismatch repair.

22 2 pathway regulating DNA damage response and DNA mismatch repair.

23 initiation of chromosome replication or for DNA mismatch repair.

24 resolving recombination intermediates and in DNA mismatch repair.

25 sover resolution and the initiation steps of DNA mismatch repair(12,13) and evoke a novel model for c

26 o DNA-damaging agents and decreases cellular DNA mismatch repair activities by downregulation of MSH2

27 The ability to monitor and characterize DNA mismatch repair activity in various mammalian cells

28 hypermutable phenotype caused by the loss of DNA mismatch repair activity.

29 region of Msh6 are important for eukaryotic DNA mismatch repair and cellular response to alkylation

30 reased tumor burden correlates with impaired DNA mismatch repair and decreased expression of Mlh1 and

31 ypes, as defined by signatures for defective DNA mismatch repair and DNA polymerase epsilon proofread

32 adation, leading to substantial reduction in DNA mismatch repair and increased resistance to thiopuri

33 reaction in DNA homologous recombination and DNA mismatch repair and is also heavily utilized in DNA-

34 ed during evolution and having dual roles in DNA mismatch repair and meiosis.

35 of many known DNA repair pathways, including DNA mismatch repair and nucleotide excision repair.

36 HNPCC patients have inherited defects in DNA mismatch repair and the microsatellite instability (

37 n human tumors is characterized by defective DNA mismatch repair and unique clinical features.

38 rD are identified and linked with defects in DNA mismatch repair and with the ability to cope with co

39 netic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and be

40 cancers, especially in tumors proficient in DNA mismatch repair, and thus represents a novel marker

41 included attachment, metabolism, transport, DNA mismatch repair, and transcriptional regulation, and

42 apeutics for cancer, because deficiencies in DNA mismatch repair are implicated in cancers, and cells

43 y, tumor cells with MSI (caused by defective DNA mismatch repair) are more resistant to 5-FU in cultu

44 antigen (PCNA) is thought to play a role in DNA mismatch repair at the DNA synthesis step as well as

45 ast MutL homologs Mlh1 and Pms1 required for DNA mismatch repair both possess independent, intrinsic

46 rocess, on an unrelated protein kinase or on DNA mismatch repair by cell extracts.

47 DNA mismatch repair, cell cycle regulation in post-mitot

48 t is widespread in bacteria and functions in DNA mismatch repair, chromosome segregation, and virulen

49 consistent with the hypothesis of Mlh1-Mlh3 DNA mismatch repair complex acting as the major endonucl

50 de and enhance nucleosome disassembly by the DNA mismatch repair complex, hMSH2-hMSH6.

51 Imaging of nucleosomes and DNA mismatch repair complexes demonstrates that DREEM ca

52 DNA mismatch repair corrects mispaired bases and small i

53 deaminase activity (COSMIC signature 2) and DNA mismatch repair (COSMIC signature 6).

54 ucleotide repeats (EMAST) is the most common DNA mismatch repair defect in colorectal cancers, observ

55 icantly contribute to genetic instability in DNA mismatch repair-defective human tumors.

56 ely specific (100%) method for screening for DNA mismatch repair defects.

57 nce supporting the significant importance of DNA mismatch repair deficiencies and the efficacy of the

58 sed neoantigens in hypermutated cancers with DNA mismatch repair deficiency (dMMR) are proposed as th

59 DNA mismatch repair deficiency (dMMR) hallmarks consensu

60 compared prevalence of proximal location and DNA mismatch repair deficiency (dMMR) in CRC tumors, rel

61 lh1 protein to study the interaction between DNA mismatch repair deficiency and DNA methylation.

62 le levels of MSH2 protein in leukemia cells, DNA mismatch repair deficiency and drug resistance.

63 d family histories and testing of tumors for DNA mismatch repair deficiency and/or microsatellite ins

64 ancers from 1,144 patients were assessed for DNA mismatch repair deficiency by two methods: MSI testi

65 nsive and up-to-date summary for the role of DNA mismatch repair deficiency in cancer, and its import

66 ned from mutation carriers demonstrating the DNA mismatch repair deficiency phenotype.

67 A feature in patients with constitutional DNA-mismatch repair deficiency is agenesis of the corpus

68 logical disorders in patients with inherited DNA-mismatch repair deficiency.

69 ced computed tomography (CE-CT) can identify DNA mismatch repair deficient (MMR-D) and/or tumor mutat

70 tic mechanism of malignant transformation in DNA mismatch repair deficient, microsatellite-unstable c

71 Metastatic DNA mismatch repair-deficient (dMMR)/microsatellite inst

72 their subsequent transformation to AML in a DNA mismatch repair-deficient background.

73 rosatellite instability (MSI-H) or defective DNA mismatch repair (dMMR) have improved survival and re

74 Deficient DNA mismatch repair (dMMR) induces a hypermutator phenot

75 The association of deficient DNA mismatch repair (dMMR) with prognosis in patients wi

76 DNA mismatch repair (DMR) functions to maintain genome s

77 Further, error rates and DNA mismatch repair efficiency both vary by mismatch typ

78 own (EXO1 - exonuclease 1) to be involved in DNA mismatch repair emerged as candidate susceptibility

79 ther show that overexpression of catalase or DNA mismatch repair enzyme, MutS, and antioxidant pretre

80 residues homologous to a hypothetical human DNA mismatch repair enzyme-related protein.

81 DNA mismatch repair enzymes (for example, MSH2) maintain

82 dynamically close mimic of G-T in studies of DNA mismatch repair enzymes.

83 In addition to repairing mismatched DNA, mismatch repair enzymes are known in higher eukaryo

84 utative endonuclease activity encoded by the DNA mismatch repair factor Mlh1-Mlh3.

85 oss-of-function missense variants in the key DNA mismatch repair factor MSH2.

86 ediated regulatory mechanism controlling the DNA mismatch repair function of MSH2.

87 MLH3 is a recently described member of the DNA mismatch repair gene family.

88 s caused by mutations resulting in defective DNA mismatch repair gene function.

89 Expression of the DNA mismatch repair gene hMLH1 is diminished or absent i

90 status of the tumor suppressor gene p16, the DNA mismatch repair gene hMLH1, and four CpG islands (MI

91 By targeting the DNA mismatch repair gene MLH1 CGI, we could generate a P

92 usively in tumors with low expression of the DNA mismatch repair gene MLH1.

93 Mutations in the human DNA mismatch repair gene MSH2 are associated with heredi

94 differential mutational burden downstream of DNA mismatch repair gene mutations and composite gene ex

95 Moreover, recent research suggests that DNA mismatch repair gene mutations may facilitate acquis

96 Defective DNA mismatch repair generates mutations at repetitive DN

97 uent identification of germline mutations in DNA mismatch repair genes (n = 47) or biallelic MUTYH mu

98 ants in base-excision (P = 2.4 x 10(-4)) and DNA mismatch repair genes (P = 6.1 x 10(-4)) consistent

99 ed hereditary breast and ovarian cancer, and DNA mismatch repair genes for suspected Lynch syndrome.

100 arate study, a decreased expression level of DNA mismatch repair genes involved in SHM in older indiv

101 Germline hypermethylation of the DNA mismatch repair genes MLH1 and MSH2 may serve as pre

102 ted for MSI, and promoter methylation of the DNA mismatch repair genes MLH1, MSH2, MLH3, MSH6, PMS2,

103 We tested these predictions by deleting the DNA mismatch repair genes MSH2 or MLH1 and analyzing the

104 Genetic or epigenetic inactivation of DNA mismatch repair genes results in a strong mutator ph

105 nstability (MSI) and promoter methylation of DNA mismatch repair genes, is common in individual gland

106 ional repair genes, RAD51 and BRCA1, and the DNA mismatch repair genes, MLH1 and MSH2, are decreased

107 adenomatous polyposis coli gene (Apc) and/or DNA mismatch repair genes, we have analyzed the genetic

108 s, the role of microRNAs and epimutations in DNA mismatch repair genes.

109 al cancer is caused by germline mutations in DNA mismatch repair genes.

110 ogenic variant in the BRCA1/2, PTEN, TP53 or DNA mismatch repair genes.

111 atients with pathogenic germline variants in DNA mismatch repair genes.

112 RCA2 (n = 98), and 8 (0.4%) had mutations in DNA mismatch repair genes.

113 to colorectal cancer caused by mutations in DNA mismatch repair genes; colorectal cancer risk is hig

114 (HNPCC) is caused by inherited mutations in DNA mismatch-repair genes, most commonly MLH1 or MSH2.

115 Defects in human DNA mismatch repair have been reported to underlie a var

116 ution of tumor stroma obscured signatures of DNA mismatch repair identified in cell lines with a hype

117 es, including microsatellite instability and DNA mismatch repair immunohistochemistry results.

118 DNA mismatch repair in Escherichia coli has been shown t

119 Introduction of mutations disabling DNA mismatch repair into these cell lines renders them r

120 s review summarizes the current knowledge of DNA mismatch repair involvement in triplet repeat expans

121 DNA mismatch repair is a conserved antimutagenic pathway

122 DNA mismatch repair is central to the maintenance of gen

123 Defective DNA mismatch repair is commonly present in sporadic mani

124 Postreplication DNA mismatch repair is essential for maintaining the int

125 In eukaryotic cells, DNA mismatch repair is initiated by a conserved family o

126 DNA mismatch repair is initiated by either the Msh2-Msh6

127 Postreplication DNA mismatch repair is initiated by the eukaryotic prote

128 DNA mismatch repair is initiated by the recognition of m

129 The process of DNA mismatch repair is initiated when MutS recognizes mi

130 DNA mismatch repair is thought to act through two subpat

131 explained by preferential recruitment of the DNA mismatch repair machinery to a protein modification

132 DNA mismatch repair maintains genomic stability by detec

133 Exonucleolytic proofreading and DNA mismatch repair (MMR) act in series to maintain high

134 Mammalian MutL homologues function in DNA mismatch repair (MMR) after replication errors and i

135 is colon cancer (HNPCC), is due to deficient DNA mismatch repair (MMR) and is defined with mono- and

136 plore this hypothesis we analyzed ERC within DNA mismatch repair (MMR) and meiosis proteins over phyl

137 rt of many DNA metabolic processes including DNA mismatch repair (MMR) and recombination.

138 ompromised by its dependence for activity on DNA mismatch repair (MMR) and the repair of the chemosen

139 Defects in DNA mismatch repair (MMR) are the molecular basis of cer

140 ity to Fen1, and because Exo1 is involved in DNA mismatch repair (MMR) by interaction with Msh2 and M

141 erodimeric human MSH2-MSH6 protein initiates DNA mismatch repair (MMR) by recognizing mismatched base

142 t and the dependence of this response on the DNA mismatch repair (MMR) capacity.

143 Ls in vitro, and that cells deficient in the DNA mismatch repair (MMR) complex MutSbeta were sensitiv

144 DNA mismatch repair (MMR) corrects errors that occur dur

145 DNA mismatch repair (MMR) couples recognition of base mi

146 Colon cancers exhibiting DNA mismatch repair (MMR) defects demonstrate distinct c

147 resistance to thiopurines is associated with DNA mismatch repair (MMR) deficiency.

148 s implicated multiple pathways in eukaryotic DNA mismatch repair (MMR) downstream of mispair recognit

149 cute myeloid leukaemia (t-AML) suggests that DNA mismatch repair (MMR) dysfunction may be an initiati

150 DNA mismatch repair (MMR) ensures replication fidelity b

151 DNA mismatch repair (MMR) ensures the fidelity of DNA re

152 Loss of DNA mismatch repair (MMR) function leads to the developm

153 Mutations in the human DNA mismatch repair (MMR) gene MLH1 are associated with

154 Germline mutations in the DNA mismatch repair (MMR) gene MLH1 are associated with

155 his effect, we report that expression of the DNA mismatch repair (MMR) gene Mlh1 is specifically redu

156 Mutations in the DNA mismatch repair (MMR) gene MSH2 cause Lynch syndrome

157 ratory indicated that expression of the MLH1 DNA mismatch repair (MMR) gene was necessary to restore

158 Lynch syndrome is caused by variants in DNA mismatch repair (MMR) genes and associated with an i

159 Mutations in DNA mismatch repair (MMR) genes cause the most common kn

160 Null mutations in DNA mismatch repair (MMR) genes elevate both base substi

161 NPCC results from germ-line mutations in the DNA mismatch repair (MMR) genes hMSH2 and hMLH1 with rar

162 tic or epigenetic inactivation of one of the DNA mismatch repair (MMR) genes in tumor precursor cells

163 Germline mutations in the DNA mismatch repair (MMR) genes MSH2 and MLH1 are respon

164 uals with heterozygous germline mutations in DNA mismatch repair (MMR) genes or hereditary nonpolypos

165 The MSH3 gene is one of the DNA mismatch repair (MMR) genes that has undergone somat

166 sed by germ-line mutations in one of several DNA mismatch repair (MMR) genes, most commonly in hMSH2

167 enic mutations, are identified in one of the DNA mismatch repair (MMR) genes.

168 (CRC) and is caused by germline mutations in DNA mismatch repair (MMR) genes.

169 of colorectal cancer caused by mutations of DNA mismatch repair (MMR) genes.

170 d effectively to study missense mutations in DNA mismatch repair (MMR) genes.

171 cancer cell lines differing by mutations in DNA mismatch repair (MMR) genes.

172 al cancer, is caused by inherited defects in DNA mismatch repair (MMR) genes.

173 DNA mismatch repair (MMR) guards the integrity of the ge

174 Defects in DNA mismatch repair (MMR) have been implicated in the ge

175 DNA mismatch repair (MMR) identifies and corrects errors

176 y a novel role for H3K36me3 that facilitates DNA mismatch repair (MMR) in cells by targeting the MMR

177 NA methyltransferase 1 (Dnmt1) deficiency on DNA mismatch repair (MMR) in mouse embryonic stem (ES) c

178 ric eukaryotic MutL homolog, is required for DNA mismatch repair (MMR) in vivo.

179 DNA mismatch repair (MMR) increases replication fidelity

180 Loss of DNA mismatch repair (MMR) increases the risk of spontane

181 ity characterized by aneuploidy or defective DNA mismatch repair (MMR) indicated by microsatellite in

182 DNA mismatch repair (MMR) is a critical genome-stabiliza

183 DNA mismatch repair (MMR) is a highly conserved mutation

184 DNA mismatch repair (MMR) is a multifunctional process t

185 DNA mismatch repair (MMR) is an efficient system for the

186 DNA mismatch repair (MMR) is an evolutionarily conserved

187 DNA mismatch repair (MMR) is critical in maintaining gen

188 Human DNA mismatch repair (MMR) is involved in the response to

189 llite instability (MSI) secondary to loss of DNA mismatch repair (MMR) is present in adenomas and col

190 DNA mismatch repair (MMR) is required for the maintenanc

191 The first step in DNA mismatch repair (MMR) is the recognition of DNA mism

192 r DNA repair, for example, by the well-known DNA mismatch repair (MMR) mechanism.

193 A problem in understanding eukaryotic DNA mismatch repair (MMR) mechanisms is linking insights

194 DNA mismatch repair (MMR) models have proposed that MSH

195 Defects in DNA mismatch repair (MMR) occur frequently in natural po

196 In Escherichia coli, a DNA mismatch repair (MMR) pathway corrects errors that o

197 n screening approach, we discovered that the DNA mismatch repair (MMR) pathway is essential for club

198 The DNA mismatch repair (MMR) pathway recognizes and repairs

199 Not all DNA repair pathways, including the DNA mismatch repair (MMR) pathway, have been well charac

200 ) is a known carcinogen that inactivates the DNA mismatch repair (MMR) pathway.

201 Although it is clear that postreplicative DNA mismatch repair (MMR) plays a critical role in maint

202 dicated that the protein factors involved in DNA mismatch repair (MMR) possess meiotic functions beyo

203 Loss of the DNA mismatch repair (MMR) protein MSH3 leads to the deve

204 MutS homolog 2 (MSH2) is an essential DNA mismatch repair (MMR) protein.

205 Human DNA mismatch repair (MMR) proteins correct DNA errors an

206 We observed a higher expression of DNA mismatch repair (MMR) proteins in EGFRvIII+ cells an

207 rest and apoptosis in a manner requiring the DNA mismatch repair (MMR) proteins MutSalpha and MutLalp

208 Defects in DNA mismatch repair (MMR) result in elevated mutagenesis

209 DNA mismatch repair (MMR) sensitizes human and Escherich

210 To determine the association of DNA mismatch repair (MMR) status and somatic mutation in

211 , bcl-2, p53, proliferation marker Ki-67 and DNA mismatch repair (MMR) status in patients with Dukes'

212 he association of body mass index (BMI) with DNA mismatch repair (MMR) status is unknown.

213 Cells with functional DNA mismatch repair (MMR) stimulate G(2) cell cycle chec

214 However, DNA mismatch repair (MMR) suppresses the efficiency of g

215 The DNA mismatch repair (MMR) system corrects DNA mismatches

216 The DNA mismatch repair (MMR) system plays a major role in p

217 Normally, this process is prevented by a DNA mismatch repair (MMR) system that maintains sequence

218 We examined whether the component of the DNA mismatch repair (MMR) system that normally recognize

219 tellites mutate more frequently in defective DNA mismatch repair (MMR) than shorter microsatellites.

220 Current published data suggest that DNA mismatch repair (MMR) triggers prolonged G(2) cell c

221 Tumors deficient or proficient in DNA mismatch repair (MMR) were identified based on detec

222 stigate an unpredicted involvement of K-H in DNA mismatch repair (MMR) where K-H depletion led to con

223 Bcl2 has been reported to suppress DNA mismatch repair (MMR) with promotion of mutagenesis,

224 In this report, we demonstrate that DNA mismatch repair (MMR), a genome maintenance system,

225 eened this library for cells with defects in DNA mismatch repair (MMR), a system that detects and rep

226 exonuclease 1 (Exo1), which participates in DNA mismatch repair (MMR), have decreased CSR and change

227 Although known to be partly dependent on DNA mismatch repair (MMR), the cytotoxicity of 6-TG rema

228 DNA mismatch repair (MMR), the guardian of the genome, c

229 ansformation process is greatly inhibited by DNA mismatch repair (MMR), the pattern of incorporation

230 rapeutic approaches for cancers deficient in DNA mismatch repair (MMR), we have carried out parallel

231 Because p21 also inhibits DNA mismatch repair (MMR), we investigated how p21 level

232 instability (MSI) is the hallmark lesion of DNA mismatch repair (MMR)-deficient cancers.

233 Dysfunction of cell-cycle checkpoints in DNA mismatch repair (MMR)-deficient cells in response to

234 investigate the effects of mutated K-ras on DNA mismatch repair (MMR)-deficient intestinal tumour fo

235 Such deletions occur one base at a time in DNA mismatch repair (MMR)-deficient yeast suggesting lar

236 ions, which occur frequently in hypermutated DNA mismatch repair (MMR)-proficient tumors and appear t

237 tal cancers are characterized by a defective DNA mismatch repair (MMR).

238 itional aspects of DNA metabolism, including DNA mismatch repair (MMR).

239 eins encoded by these genes are required for DNA mismatch repair (MMR).

240 Both processes involve DNA mismatch repair (MMR).

241 Small looped mispairs are corrected by DNA mismatch repair (MMR).

242 of specific DNA repair processes, most often DNA mismatch repair (MMR).

243 tide selectivity, proofreading activity, and DNA mismatch repair (MMR).

244 unteract a cell cycle checkpoint mediated by DNA mismatch repair (MMR).

245 proliferating cell nuclear antigen (PCNA) in DNA mismatch repair (MMR).

246 ary colon cancer, is a syndrome of deficient DNA mismatch repair (MMR).

247 me, DNA replication is generally followed by DNA mismatch repair (MMR).

248 in A (RPA) is involved in multiple stages of DNA mismatch repair (MMR); however, the modulation of it

249 Germ line DNA mismatch repair mutations in MLH1 and MSH2 underlie

250 In the absence of DNA mismatch repair (mutL) some of these effects are red

251 hose tumors showed the presence of defective DNA mismatch repair (n = 62).

252 athways, including homologous recombination, DNA mismatch repair, nucleotide excision repair, and tra

253 tic interaction of the Mgmt null gene with a DNA mismatch repair null gene, namely Msh6.

254 anine identified all expected members of the DNA mismatch repair pathway, whereas another for the DNA

255 y direct conversion, most likely through the DNA mismatch repair pathway.

256 They included: (1) The genes involved in "DNA mismatch repair" pathway were up-regulated in HPV-po

257 Defects in human DNA mismatch repair predispose to cancer, but many compo

258 f mutagenic DNA 8-oxoG and demonstrated that DNA mismatch repair prevented oxidation-related frameshi

259 Defects in the DNA mismatch repair process dramatically increase the ri

260 the use of transient regulation of cellular DNA mismatch repair processes to enhance traits (e.g., a

261 ls have similar mechanistic efficacy against DNA mismatch repair-proficient tumor cells that lack exp

262 Inactivation of DNA mismatch repair propels colorectal cancer (CRC) tumo

263 s (UvrD, RecG, RecQ), truncated forms of the DNA mismatch repair protein (MutS) and a primosomal comp

264 ons could also reliably identify tumors with DNA mismatch repair protein deficiency (MMR-D) on the ba

265 osatellite instability from reduction of the DNA mismatch repair protein MLH1, are unaffected by CENP

266 protein has been shown to interact with the DNA mismatch repair protein MLH1.

267 p) and one of its weak-binding partners, the DNA mismatch repair protein MutL.

268 The DNA mismatch repair protein PMS2 was recently found to e

269 MutL homolog 1 (MLH1) is a key DNA mismatch repair protein, which plays an important ro

270 MSH2 is a key DNA mismatch repair protein, which plays an important ro

271 MutS protein homolog 2 (MSH2) is a key DNA mismatch repair protein.

272 oth Chfr and Mlh1 (the gene that encodes the DNA mismatch-repair protein Mlh1) displayed dramatically

273 al approach, based on detection of foci of a DNA mismatch-repair protein, MLH1, on synaptonemal compl

274 y focuses on the long-range communication in DNA mismatch repair proteins MutS and its homologs where

275 rs that prevent carcinogenesis (such as p53, DNA mismatch repair proteins, and DNA base excision-repa

276 g codon variants in transporter proteins and DNA mismatch repair proteins.

277 on highly conserved meiotic regulators, the DNA mismatch repair proteins.

278 MSH2 is required for DNA mismatch repair recognition in eukaryotes.

279 Pms1 may be relevant to its participation in DNA mismatch repair, recombination and cellular response

280 , MBD4 serves as a potent DNA glycosylase in DNA mismatch repair specifically targeting mCpG/TpG mism

281 s were compared with pathological variables, DNA mismatch repair status, and patient survival using C

282 ons in the same LEF1 allele, irrespective of DNA mismatch repair status.

283 tion by frameshift reversion is modulated by DNA mismatch-repair status and occurs in individual cell

284 fic manner by inactivation of PMS1-dependent DNA mismatch repair, suggesting that the mutator effects

285 The DNA mismatch repair system (MMR) identifies replication

286 instability (MSI) are caused by a defective DNA mismatch repair system that leads to the accumulatio

287 igh mutability is due to a saturation of the DNA mismatch repair system, leading to hypermutability a

288 o understand the evolutionary process of the DNA mismatch repair system, we conducted systematic phyl

289 cognised and repaired by the proteins of the DNA mismatch repair system, which identify the mismatch

290 rium Helicobacter pylori lacks a MutSLH-like DNA mismatch repair system.

291 cognized and repaired efficiently by meiotic DNA mismatch repair systems.

292 more frequently in isolates with defects in DNA mismatch repair that confer an elevated mutation rat

293 MSI is a molecular marker of defective DNA mismatch repair that is detected in approximately 15

294 Combining RNR deregulation with defects in DNA mismatch repair, the cellular mutation correction sy

295 or Dam methylase: directing post-replicative DNA mismatch repair to the correct strand, guiding the t

296 ion of this result is that the efficiency of DNA mismatch repair varies in different regions of the g

297 ound that the most common cause of defective DNA mismatch repair was low levels of the variant Msh2 p

298 ) hypermutated group that includes defective DNA mismatch repair with microsatellite instability and

299 Treatment of colon tumor cells deficient in DNA mismatch repair with the death-receptor ligand apo2

300 the transcription factor HIF-1alpha impairs DNA mismatch repair, yet the role of HIF-1alpha isoform,