ライフサイエンスコーパス: DNA polymerase beta

1 uplex DNA containing a one-nucleotide gap by DNA polymerase beta.

2 with several replicative DNA polymerases and DNA polymerase beta.

3 tic replicating polymerase, is homologous to DNA polymerase beta.

4 by the BER enzymes, DNA ligase IIIalpha and DNA polymerase beta.

5 ylases and reduced DNA synthesis capacity by DNA polymerase beta.

6 ng to a large enzyme superfamily typified by DNA polymerase beta.

7 ncoming nucleotide in the active site, as in DNA polymerase beta.

8 ot substitute for PCNA in the stimulation of DNA polymerase beta.

9 ading activity for the relatively inaccurate DNA polymerase beta.

10 air extension ability, relative to wild-type DNA polymerase beta.

11 asic sites to facilitate repair synthesis by DNA polymerase beta.

12 is homologous to part of the 8 kDa domain of DNA polymerase beta.

13 id was also incorporated into position 72 of DNA polymerase beta.

14 s catalytic activity or its interaction with DNA polymerase beta.

15 pendent DNA cleavage and strongly inhibiting DNA polymerase beta.

16 thway by interacting with DNA ligase III and DNA polymerase beta.

17 he critical DNA base excision repair enzyme, DNA polymerase beta.

18 ened for the ability to irreversibly inhibit DNA polymerase beta.

19 nt antitumor agents were shown to inactivate DNA polymerase beta.

20 NMR measurements of [methyl-(13)C]methionine DNA polymerase beta.

21 ble Fapy*dGTP analog, beta-C-Fapy*dGTP, with DNA polymerase beta.

22 erase that shares 34% sequence identity with DNA polymerase beta.

23 DNA polymerase beta, a member of the X family of DNA pol

24 GTP, which forms an active site complex with DNA polymerase beta, a repair enzyme that plays an impor

25 he specific catalytic roles of two groups of DNA polymerase beta active site residues identified from

26 the reverse reaction in the confines of the DNA polymerase beta active site.

27 r; this reduces OGG1, AP endonuclease 1, and DNA polymerase beta activities.

28 e near the 3' terminus did not affect either DNA polymerase beta activity or poly(ADP)ribose polymera

29 ternative gap-filling pathways by inhibiting DNA polymerase beta activity.

30 activity correlated tightly with changes in DNA polymerase beta and AP site DNA binding levels.

31 protein-like box sequence in APC that binds DNA polymerase beta and blocks DNA polymerase beta-media

32 between the isolated 8-kDa domain of the rat DNA polymerase beta and DNA have been studied, using the

33 the known repair enzymes, AP-endonuclease 1, DNA polymerase beta and DNA ligase III.

34 with purified human enzymes including APE1, DNA polymerase beta and DNA ligase IIIalpha.

35 n step of long-patch BER with purified human DNA polymerase beta and FEN1.

36 ith downstream base excision repair proteins DNA polymerase beta and flap endonuclease-1 by 4-6-fold.

37 incorporated into double-stranded DNA using DNA polymerase beta and functioned as both the damage si

38 two promising genes in the DNA repair enzyme DNA polymerase beta and in the neuroendocrine transcript

39 een the in vitro replication errors of human DNA polymerase beta and in vivo point mutations of the a

40 -turnover kinetic methods, we examined human DNA polymerase beta and its novel X-family homolog, huma

41 nd the damaged strands that were bypassed by DNA polymerase beta and processed by flap endonuclease 1

42 alized similarity in the catalytic domain to DNA polymerase beta and related nucleotidyltransferases.

43 of cell replication-related proteins such as DNA polymerase beta and subunits of DNA polymerase delta

44 alpha or DNA ligase I, inhibits extension by DNA polymerase beta and that the lesion is resistant to

45 Interactions between human DNA polymerase beta and the template-primer, as well as

46 from apurinic/apyrimidinic endonuclease 1 to DNA polymerase beta and then to DNA ligase.

47 cleosome core are preferentially repaired by DNA polymerase beta and there is a significant reduction

48 R proteins, namely, DNA ligase III alpha and DNA polymerase beta and thus could form a large multipro

49 However, binding of hMYH to DNA polymerases beta and delta was not detected.

50 DNA polymerases beta and eta are among the few eukaryoti

51 nesis, we conducted kinetic studies of human DNA polymerases beta and eta replicating across oxoA and

52 determined to be 5.7-7.2 x 10(-4) when using DNA polymerase beta (+/+) and (-/-) cell-free extracts.

53 Efficient repair was observed in both DNA polymerase beta (+/+) and (-/-) cell-free extracts.

54 using homozygous mouse embryonic fibroblast DNA polymerase beta (+/+) and (-/-) cells to determine t

55 A type II DNA topoisomerase, a DNA polymerase beta, and a structure-specific endonuclea

56 nd the BER participants flap endonuclease-1, DNA polymerase beta, and apurinic/apyrimidinic endonucle

57 man uracil DNA glycosylase, AP endonuclease, DNA polymerase beta, and DNA ligase 1 replace uracil opp

58 The scaffold protein XRCC1, DNA polymerase beta, and DNA ligase IIIalpha play pivota

59 , apurinic/apyrimidinic (AP) endonuclease 1, DNA polymerase beta, and DNA ligases.

60 DOB is a potent irreversible inhibitor of DNA polymerase beta, and forms interstrand cross-links i

61 PE1, the DNA strand displacement activity of DNA polymerase beta, and incision of a 1- or 10-nucleoti

62 such as apurinic/apyrimidinic endonuclease, DNA polymerase beta, and ligases, require Mg(2+).

63 itecture of the nucleotide binding pocket of DNA polymerase beta, and that alterations of this residu

64 Mouse fibroblasts, deficient in DNA polymerase beta, are hypersensitive to monofunctiona

65 effect of the protein residues, taking human DNA polymerase beta as a model system.

66 n aphidicolin-resistant polymerase, probably DNA polymerase-beta, becomes the primary polymerase.

67 In single-nucleotide BER, DNA polymerase beta (beta-pol) accounts for both gap fil

68 e (Aag) recognizes and removes the base, and DNA polymerase beta (beta-pol) contributes the gap tailo

69 ry cAMP response element (CRE)1 in the human DNA polymerase beta (beta-pol) core promoter plays a key

70 To establish the role of DNA polymerase beta (beta-pol) in BER and beta-pol-depen

71 n either BER or its rate-determining enzyme, DNA polymerase beta (beta-pol) is observed in response t

72 DNA polymerase beta (beta-pol) plays a central role in r

73 effect of Sp1 on the activation of the human DNA polymerase beta (beta-pol), a TATA-less promoter.

74 One contributing factor is the abundance of DNA polymerase beta (beta-pol), an enzyme required for B

75 DNA repair protein that forms complexes with DNA polymerase beta (beta-Pol), DNA ligase III and poly-

76 ms a base excision repair (BER) complex with DNA polymerase beta (beta-Pol).

77 ct was partially inhibited by an antibody to DNA polymerase beta (beta-pol).

78 Three regions in human and rat DNA polymerases beta (beta-pol) that resemble the consen

79 tructurally homologous to the palm domain of DNA polymerase beta but has additional structural featur

80 These results indicate that DNA polymerase beta can induce a strain in the DNA that

81 DNA polymerase beta carries out two of the four steps du

82 The mechanism of DNA polymerase beta-catalyzed nucleotidyl transfer consi

83 Addition of p21 peptide or protein to DNA polymerase beta (+/+) cell-free extracts increased t

84 th that observed in the crystal structure of DNA polymerase beta complexed with magnesium and dNTP an

85 escribed a general mutator form of mammalian DNA polymerase beta containing a cysteine substitution f

86 Aging and DNA polymerase beta deficiency (beta-pol(+/-)) interact

87 Using human DNA polymerase beta, deoxyoxanosine triphosphate is only

88 DNA polymerase beta discourages ribonucleotide insertion

89 also consistent with the interpretation that DNA polymerase beta discriminates the correct from incor

90 TP analogs (dT) was demonstrated to fit into DNA polymerase beta (DNA pol beta) binding pocket by obt

91 nting gene I protein (XRCC1) in complex with DNA polymerase beta, DNA ligase III, and poly(ADP-ribose

92 ression of XRCC1-associated proteins such as DNA polymerase beta, DNA ligase III, poly(ADP-ribose) po

93 ates the sequential binding and catalysis by DNA polymerase beta, DNA polymerase delta, FEN1, and DNA

94 tides 130-fold tighter, on average, than the DNA polymerase beta-DNA complex, although the base subst

95 olymerase with only one metal ion bound, the DNA polymerase beta-DNA template-primer-chromium(III).2'

96 excision repair pathway, and mice devoid of DNA polymerase beta do not live beyond a few hours after

97 In contrast, the related mammalian DNA polymerase beta does not form a complex with Ku and

98 ay enhance the base substitution fidelity of DNA polymerase beta during single nucleotide BER.

99 DNA constructs in vitro, we find that human DNA polymerase beta effectively catalyzes CAG/CTG triple

100 These data support the hypothesis that DNA polymerase beta errors are an important fraction of

101 ethod, we could follow the activity of human DNA polymerases beta, eta, iota and kappa under differen

102 blocking termini were activated by Ape1 for DNA polymerase beta extension.

103 The hydrophobic hinge of DNA polymerase beta facilitates closing and stabilizatio

104 eotidyltransferase (NTase) and member of the DNA polymerase beta family.

105 osylase, apurinic/apyrimidinic endonuclease, DNA polymerase beta, flap endonuclease-1 (FEN-1), and PA

106 The DNA polymerase beta from the trypanosomatid Crithidia fa

107 Compared to the higher fidelity DNA polymerase beta from the X-family, Dpo4 has a higher

108 Because DNA polymerase beta functions in base excision repair, o

109 Mammalian DNA polymerase beta functions in the base excision DNA r

110 he fidelity of another inefficient mutant of DNA polymerase beta (G274P) is not altered.

111 ed strand is blocked, the intermediate after DNA polymerase beta gap filling is not channeled to the

112 E1 strand cleavage and stimulated subsequent DNA polymerase beta-gap filling activity by 30-fold.

113 of the catalytic divalent ion to the ternary DNA polymerase beta/gapped DNA/dNTP complex is thought t

114 nucleotide incorporation and illustrate how DNA polymerase beta has evolved to hinder Fapy*dGTP inse

115 We also show that DNA polymerase beta has low fidelity at the cisplatin IC

116 DNA polymerase beta has two DNA-binding domains that int

117 e excision repair (BER)-deficient model, the DNA polymerase beta heterozygous mouse, to investigate t

118 eps during nucleotide incorporation by human DNA polymerase beta (hPolbeta) and provide a structural

119 epair of 8-oxoG:dA base pairs requires human DNA polymerase beta (hPolbeta) to bypass 8-oxoG.

120 Here, we have solved structures of human DNA polymerase beta (hPolbeta), in complex with single-n

121 tallography to follow 8-oxoG bypass by human DNA polymerase beta (hPolbeta).

122 The transient appearance of DNA polymerase beta in photoreceptors under these experi

123 to a molecule that irreversibly inactivates DNA polymerase beta in solution (IC50 approximately 21 m

124 We determined the error spectrum of DNA polymerase beta in the human APC gene under PCR cond

125 mulates strand displacement DNA synthesis by DNA polymerase beta in this system; this stimulation is

126 tuent was found to be a critical element for DNA polymerase beta inhibition, since compounds 1 and 2

127 The most potent DNA polymerase beta inhibitors were bis(dihydroxyalkylbe

128 DNA polymerase beta is a repair polymerase that provides

129 The large-scale opening motion of mammalian DNA polymerase beta is followed at atomic resolution by

130 show here that subsequent excision by human DNA polymerase beta is impaired at dL compared with unmo

131 d that SSB repair by DNA ligase IIIalpha and DNA polymerase beta is impaired by the presence of the n

132 DNA polymerase beta is known to be a key player in the b

133 the incorporation of dGTP catalyzed by human DNA polymerase beta is not affected when 5-methylcytosin

134 oxynucleoside triphosphate, alpha-helix N of DNA polymerase beta is observed to form one face of the

135 DNA polymerase beta is overexpressed in cancer cells and

136 e included in the reaction or when wild type DNA polymerase beta is replaced by DNA polymerase beta v

137 DNA polymerase beta is the predominant crosslinked prote

138 a, a recently identified X-family homolog of DNA polymerase beta, is hypothesized to be a second poly

139 stage embryos and adults are the absence of DNA polymerase-beta, leading to predominance of replicat

140 to human DNA polymerase beta, the C-terminal DNA polymerase beta-like domain alone displays a dramati

141 is comprised of three domains: a C-terminal DNA polymerase beta-like domain, an N-terminal BRCA1 C-t

142 Crystallographic studies of the C-terminal DNA polymerase-beta-like domain of full-length human DNA

143 rating enzymes include several clades of the DNA-polymerase beta-like superfamily (including Vibrio c

144 PC that binds DNA polymerase beta and blocks DNA polymerase beta-mediated strand-displacement synthes

145 n NCPs decreases the gap-filling activity of DNA polymerase beta near the dyad center, with H3K14Ac e

146 It is a divergent member of the DNA polymerase beta nucleotidyl transferase superfamily,

147 vitro single-nucleotide BER deficiency of a DNA polymerase beta null cell extract.

148 ld-type and, in particular, repair-deficient DNA polymerase beta null cells are highly sensitized to

149 n potential, during DNA replication by human DNA polymerase beta, of several tetranucleotide repeat t

150 DNA polymerase beta offers an attractive system to study

151 activity of the uracil-DNA glycosylases and DNA polymerase beta on nucleosome cores.

152 and 40-fold, respectively, but not those of DNA polymerase beta or Klenow fragment of E.coli DNA pol

153 yribose-5-phosphate lyase activity of either DNA polymerase beta or lambda is believed to occur after

154 ient in x-ray cross-complementing protein 1, DNA polymerase beta, or poly (ADP-ribose) polymerase 1 a

155 the activation of a TATA-containing chimeric DNA polymerase beta (pAS8) promoter.

156 DNA polymerase beta plays a critical role in base-excisi

157 DNA polymerase beta plays a key role in base excision re

158 ) studies on the enzyme-DNA complexes of rat DNA polymerase beta (Pol beta) and African swine fever v

159 bers of the X-family of DNA polymerases: rat DNA polymerase beta (Pol beta) and African swine fever v

160 To do this, here we employed human DNA polymerase beta (pol beta) and characterized r8-oxo-

161 L1 stably interacts with other BER proteins, DNA polymerase beta (pol beta) and DNA ligase IIIalpha.

162 n vitro, we found that TRF2 physically bound DNA polymerase beta (Pol beta) and flap endonuclease 1 (

163 DNA polymerase beta (pol beta) and flap endonuclease 1 (

164 DNA ligase IIIalpha and also interacts with DNA polymerase beta (Pol beta) and other base excision r

165 t shares a number of characteristics of both DNA polymerase beta (pol beta) and terminal deoxynucleot

166 onuclease from the incised abasic site, both DNA polymerase beta (Pol beta) and the DNA ligase IIIalp

167 teady-state kinetic analyses using wild-type DNA polymerase beta (pol beta) and two active-site mutan

168 We use DNA polymerase beta (pol beta) as a model system to inve

169 of 8-oxoguanine (8-oxodG) in TNR sequences, DNA polymerase beta (POL beta) can incorporate 8-oxodGMP

170 p junctions and whether a specific siRNA for DNA polymerase beta (pol beta) can move from one cell to

171 We investigated DNA polymerase beta (POL beta) capacity to incorporate r

172 DNA polymerase beta (Pol beta) carries out strand displa

173 the R283K mutant of human DNA repair enzyme DNA polymerase beta (pol beta) differing in the number o

174 To elucidate how human DNA polymerase beta (pol beta) discriminates dATP from d

175 ssion and short hairpin RNA-mediated loss of DNA polymerase beta (Pol beta) expression in human breas

176 Human DNA polymerase beta (pol beta) fills gaps in DNA as part

177 hich is demonstrated by the observation that DNA polymerase beta (pol beta) gap-filling synthesis act

178 We have identified several mutations of the DNA polymerase beta (pol beta) gene in human colorectal

179 2-AP) as a probe in stopped-flow analyses of DNA polymerase beta (Pol beta) had provided important me

180 While matched nucleotide incorporation by DNA polymerase beta (Pol beta) has been well-studied, a

181 DNA polymerase beta (pol beta) has long been described a

182 Crystallographic characterization of DNA polymerase beta (pol beta) has suggested that multip

183 Mutations in DNA polymerase beta (pol beta) have been associated with

184 filling polymerase activity was not due to a DNA polymerase beta (pol beta) homolog, or to another X-

185 ure of the human base excision repair enzyme DNA polymerase beta (Pol beta) in complex with a 1-nt ga

186 f different intermediate states of mammalian DNA polymerase beta (Pol beta) in its wild-type and an e

187 DNA polymerase beta (Pol beta) is a 39-kDa enzyme that p

188 DNA polymerase beta (pol beta) is a bifunctional enzyme

189 DNA polymerase beta (pol beta) is a central participant

190 During DNA repair, DNA polymerase beta (Pol beta) is a highly dynamic enzym

191 DNA polymerase beta (Pol beta) is a key enzyme in DNA ba

192 Deoxyribose phosphate (dRP) removal by DNA polymerase beta (Pol beta) is a pivotal step in base

193 DNA polymerase beta (pol beta) is an ideal system for st

194 etween the XRCC1 N-terminal domain (NTD) and DNA polymerase beta (Pol beta) is central to base excisi

195 DNA polymerase beta (pol beta) is responsible for gap fi

196 DNA polymerase beta (Pol beta) is responsible for the re

197 DNA polymerase beta (pol beta) is the key gap-filling po

198 DNA polymerase beta (pol beta) is the main polymerase in

199 DNA polymerase beta (pol beta) is the main polymerase in

200 DNA polymerase beta (pol beta) is the only mammalian DNA

201 verse rate of the conformational step in the DNA polymerase beta (Pol beta) kinetic pathway.

202 e template strand, which was skipped over by DNA polymerase beta (pol beta) lesion bypass synthesis.

203 We have examined the mechanism of DNA polymerase beta (pol beta) lesion discrimination usi

204 We have shown earlier that DNA polymerase beta (Pol beta) localizes to the synapton

205 DNA polymerase beta (pol beta) offers a simple system to

206 pyrimidinic/apurinic endonuclease (APE), and DNA polymerase beta (pol beta) on homogeneously damaged,

207 DNA polymerase beta (Pol beta) plays a key role in base

208 Eukaryotic DNA polymerase beta (Pol beta) plays an important role i

209 se excision repair (BER), and in vertebrates DNA polymerase beta (pol beta) provides gap filling and

210 Earlier results had indicated that purified DNA polymerase beta (pol beta) removes the entire 5'-AMP

211 DNA polymerase beta (pol beta) requires nuclear localiza

212 DNA polymerase beta (pol beta) selects the correct deoxy

213 ported that WRN helicase activity stimulates DNA polymerase beta (pol beta) strand displacement synth

214 ructures of open and closed conformations of DNA polymerase beta (pol beta) suggests that the rate of

215 In contrast, DNA polymerase beta (Pol beta) synthesis is inhibited in

216 recruited to DNA lesions and associates with DNA polymerase beta (Pol beta) to function in DNA repair

217 erichia coli DNA polymerase I (Kfexo(-)) and DNA polymerase beta (pol beta) using (19)F NMR, insertio

218 f human tumors characterized to date express DNA polymerase beta (pol beta) variant proteins.

219 scale sequencing studies have indicated that DNA polymerase beta (pol beta) variants are present on a

220 DNA polymerase beta (Pol beta) was implicated recently a

221 DNA polymerase beta (Pol beta), a key enzyme in the DNA

222 DNA polymerase beta (Pol beta), a member of the DNA poly

223 Mammalian DNA polymerase beta (pol beta), a small (39 kDa) member

224 iciently and irreversibly inhibits repair by DNA polymerase beta (Pol beta), an integral enzyme in ba

225 onstrated for the N-terminal 8 kDa domain of DNA polymerase beta (Pol beta), and for the homologous d

226 apurinic/apyrimidinic endonuclease 1 (APE1), DNA polymerase beta (pol beta), flap endonuclease 1 (FEN

227 id (LCA), an inhibitor of the key BER enzyme DNA polymerase beta (pol beta), in cells deficient in ex

228 The DNA repair enzyme, DNA polymerase beta (Pol beta), is among the most discri

229 monstrate large-scale subdomain movements as DNA polymerase beta (pol beta), significant DNA motion e

230 1/HectH9) as an enzyme that can ubiquitylate DNA polymerase beta (Pol beta), the major BER DNA polyme

231 cant proportion of human cancers overexpress DNA polymerase beta (Pol beta), the major DNA polymerase

232 irus reverse transcriptase (AMV-RT) or human DNA polymerase beta (pol beta), was significantly impair

233 opped-flow fluorescence assays for mammalian DNA polymerase beta (Pol beta), we have previously ident

234 lase hNTH1, apurinic endonuclease (APE), and DNA polymerase beta (Pol beta), which catalyze the first

235 n contrast with another X-family polymerase, DNA polymerase beta (pol beta), which inserts G*G mismat

236 purinic/aprymidinic endonuclease 1 (APE) and DNA polymerase beta (Pol beta).

237 both with the AP endonuclease (APE) and with DNA polymerase beta (pol beta).

238 phate is removed by the AP lyase activity of DNA polymerase beta (Pol beta).

239 in macrophages was heavily reliant upon host DNA polymerase beta (Pol beta).

240 d their structures in ternary complexes with DNA polymerase beta (pol beta).

241 Nanosecond dynamics simulations for DNA polymerase beta (pol beta)/DNA complexes with three

242 ibose-5-phosphate (5'-dRP) lyase activity of DNA polymerase beta (pol beta): here we show, in vitro a

243 We have shown that APC interacts with DNA polymerase beta (Pol-beta) and flap endonuclease 1 (

244 es had shown that an interaction of APC with DNA polymerase beta (pol-beta) blocks strand-displacemen

245 isogenic cells deficient in the BER enzymes DNA polymerase-beta (pol-beta) and alkyladenine DNA glyc

246 ) repair pathway, can directly interact with DNA polymerase-beta (Pol-beta), a central player in the

247 G analogue, 2'-fluoro-m7dG (Fm7dG), by human DNA polymerase beta (polbeta) and solved three X-ray str

248 epair, a tight heterodimer complex formed by DNA polymerase beta (Polbeta) and XRCC1 is thought to fa

249 e determined seven x-ray structures of human DNA polymerase beta (polbeta) bound to DNA bearing 8-bro

250 on encountering dL, AP lyase enzymes such as DNA polymerase beta (Polbeta) form dead-end, covalent in

251 lines containing wild-type (MEF-polbeta) or DNA polymerase beta (polbeta) gene-knockout (MEFpolbetaK

252 DNA polymerase beta (Polbeta) has been implicated in bas

253 Human DNA polymerase beta (polbeta) has been suggested to play

254 Human DNA polymerase beta (polbeta) inserts, albeit slowly, T

255 DNA polymerase beta (Polbeta) is a DNA repair protein th

256 DNA polymerase beta (POLbeta) is a highly conserved prot

257 Using a DNA Polymerase beta (Polbeta) variant deficient in polym

258 Normally, DNA polymerase beta (Polbeta) would replace the dC deami

259 DNA polymerase beta (polbeta), a member of the X family

260 coordination of Mg(2+) or in the presence of DNA polymerase beta (polbeta), an interactive protein pa

261 inic/apyrimidinic endonuclease 1 (Apex1) and DNA polymerase beta (Polbeta), and apoptosis in the brai

262 probing ternary complexes comprised of Ape1, DNA polymerase beta (Polbeta), and different BER DNA int

263 antitatively a number of complexes formed by DNA polymerase beta (Polbeta), apurinic/apyrimidinic end

264 We have detected DNA polymerase beta (Polbeta), known as a key nuclear ba

265 lular impact of the T304I cancer mutation of DNA Polymerase beta (Polbeta), we find that mutation of

266 mismatch discrimination mechanisms of human DNA polymerase beta (polbeta), we report four crystal st

267 oss-links (DPCs) with repair enzymes such as DNA polymerase beta (polbeta).

268 While DNA polymerase beta preferentially incorporated dCTP ove

269 In fact, eggs and early stage embryos lack DNA polymerase-beta protein.

270 rect) insertion for a low fidelity mutant of DNA polymerase beta (R283A) and exonuclease-deficient DN

271 DNA polymerase beta readily inserts dideoxynucleoside tr

272 Specific inhibition of DNA polymerase beta reduced the numbers of cells survivi

273 and fidelity, we investigate the role of key DNA polymerase beta residues on subdomain motion through

274 l, strikingly different transition states in DNA polymerase beta's conformational closing for correct

275 binary DNA and ternary DNA-dNTP complexes of DNA polymerase beta, several side chains have been impli

276 TUTases belong to the DNA polymerase beta superfamily of nucleotidyltransferas

277 ential conformational changes brings the DNA/DNA polymerase beta system to a state nearly competent f

278 eversible inhibitor of the lyase activity of DNA polymerase beta that works synergistically with a DN

279 ambda has almost identical fidelity to human DNA polymerase beta, the C-terminal DNA polymerase beta-

280 dentically as they are in their complex with DNA polymerase beta, thereby proving that the eubacteria

281 ine residue inhibits DNA repair synthesis by DNA polymerase beta, thus delaying repair.

282 DNA polymerase lambda is more efficient than DNA polymerase beta to fill this oxidized single-nucleot

283 of the model to nonspecific binding of human DNA polymerase beta to ssDNA demonstrates the significan

284 Here, we investigate the ability of DNA polymerase beta to utilize nucleotides with modified

285 explicit solvent, the closing transition of DNA polymerase beta, unravels atomic and energetic detai

286 Our results support a model where DNA polymerase beta utilizes two strategies, steric and

287 The Leu22Pro (L22P) DNA polymerase beta variant was identified in a gastric

288 wild type DNA polymerase beta is replaced by DNA polymerase beta variants that fill single nucleotide

289 nt of the 189 tumors studied to date express DNA polymerase beta variants.

290 Monocytes and DNA polymerase beta were monitored by immunohistochemist

291 es within the 8 kDa amino terminal domain of DNA polymerase beta, which exhibits dRP lyase activity.

292 modeling investigation in the active site of DNA polymerase beta, which is known to incorporate both

293 21 is likely to relate to the utilization of DNA polymerase beta, which is not sensitive to p21, in t

294 t ternary complex crystal structure of human DNA polymerase beta with a G:A mismatch in the active si

295 We report the crystallographic structures of DNA polymerase beta with dG-dAMPCPP and dC-dAMPCPP misma

296 X-ray crystallographic structures of human DNA polymerase beta with nonhydrolyzable analogs contain

297 at 3, 4, and 6 exhibited mixed inhibition of DNA polymerase beta with respect to both activated DNA a

298 the base excision repair pathway, wild-type DNA polymerase beta (WT polbeta) provides most of the ga

299 Human DNA polymerase beta (X family) extends the cap primer pr

300 Variants of DNA polymerase beta, Y265F and Y265W, were analyzed for