ライフサイエンスコーパス: DNA polymerase zeta

1 ile extension involves a complex of Rev1 and DNA polymerase zeta.

2 translesion synthesis (TLS) as a subunit of DNA polymerase zeta.

3 t, and then progresses past the adduct using DNA polymerase zeta.

4 experiments suggest that extension requires DNA polymerase zeta.

5 known translesion synthesis enzymes Rev1 and DNA polymerase zeta.

6 lication employing the REV1 gene product and DNA polymerase zeta.

7 ase to be described, and is therefore called DNA polymerase zeta.

8 yeast gene encodes the catalytic subunit of DNA polymerase zeta, a nonessential enzyme that is thoug

9 These data implicate DNA polymerase zeta, a nonreplicative polymerase, in the

10 Accordingly, DNA polymerase zeta activity was essential for mutagenes

11 ed MNV mutational signatures associated with DNA polymerase zeta, an error-prone translesion polymera

12 s is the first report demonstrating that the DNA polymerase zeta and Rev1 proteins function in the mi

13 t in budding yeast Saccharomyces cerevisiae, DNA polymerase zeta and Rev1 proteins participate in the

14 DNA polymerase zeta catalytic subunit REV3 is known to p

15 7 probably functions with hREV3 in the human DNA polymerase zeta complex.

16 contributes to increasing the proficiency of DNA polymerase zeta-dependent TLS.

17 sed involvement of the mutagenic translesion DNA polymerase zeta during DNA replication.

18 data are best explained by a direct role for DNA polymerase zeta in Ig hypermutation.

19 n of Saccharomyces cerevisiae functions with DNA polymerase zeta in mutagenic trans-lesion synthesis.

20 To examine a role of DNA polymerase zeta in somatic hypermutation, we generat

21 , the gene encoding the catalytic subunit of DNA polymerase zeta involved in translesional synthesis,

22 We show that DNA polymerase zeta is absolutely required for translesi

23 at when cisplatin adducts are present in the DNA, polymerase zeta is an important contributor to cisp

24 The activity of the Rev3 protein (DNA polymerase zeta) is apparently more important for th

25 eukaryotes, and that the REV3, REV7-encoded DNA polymerase zeta mediates the mutagenic bypass of AP

26 REV1 functions in the DNA polymerase zeta mutagenesis pathway.

27 the recombination, which depended neither on DNA polymerase zeta nor on mismatch repair.

28 The DNA polymerase zeta of Saccharomyces cerevisiae is requi

29 To test the hypothesis that DNA polymerase zeta participates in Ig hypermutation, we

30 DNA polymerase zeta participates in translesional bypass

31 DNA polymerase zeta (Pol zeta) and Rev1 are essential fo

32 DNA polymerase zeta (Pol zeta) and Rev1 are key players

33 Here, we survey the diverse functions of DNA polymerase zeta (pol zeta) in eukaryotes.

34 Rev3L encodes the catalytic subunit of DNA polymerase zeta (pol zeta) in mammalian cells.

35 DNA polymerase zeta (Pol zeta) is a eukaryotic B-family

36 DNA polymerase zeta (pol zeta) is exceptionally importan

37 elements from human CFS FRA16D, we find that DNA polymerase zeta (Pol zeta) is required to prevent br

38 DNA polymerase zeta (pol zeta) participates in several D

39 DNA polymerase zeta (Pol zeta) plays a key role in DNA t

40 requires reverse transcriptase, translesion DNA polymerase zeta (Pol zeta) plays a major role in R-T

41 DNA polymerase zeta (Pol zeta), a heterodimer of Rev3 an

42 DNA polymerase zeta (pol zeta), which is required for DN

43 es, functions in lesion bypass together with DNA polymerase zeta (Pol zeta).

44 The Rev3 and Rev7 proteins are subunits of DNA polymerase-zeta (Pol-zeta), an enzyme whose sole fun

45 In contrast, DNA polymerases zeta (pol zeta) and epsilon (pol epsilon

46 HCV induced error-prone DNA polymerase zeta, polymerase iota, and activation-ind

47 spontaneous and induced DNA damage relies on DNA polymerase zeta (Polzeta) activity.

48 DNA polymerase zeta (Polzeta) and Rev1 contribute to the

49 Rev1 and DNA polymerase zeta (Polzeta) are involved in the tolera

50 Of the candidate polymerases, we identify DNA polymerase zeta (Polzeta) as a potential reverse tra

51 DNA polymerase zeta (Polzeta) belongs to the same B-fami

52 Although the DNA polymerase zeta (polzeta) catalytic subunit REV3L is

53 cts promote the participation of error-prone DNA polymerase zeta (Polzeta) in replication of undamage

54 DNA polymerase zeta (polzeta) is critical for bypass of

55 The B-family multi-subunit DNA polymerase zeta (Polzeta) is important for translesi

56 In the yeast Saccharomyces cerevisiae, DNA polymerase zeta (Polzeta) is required in a major les

57 Without H2Bub1, DNA polymerase zeta (Polzeta) is responsible for a highl

58 The DNA polymerase zeta (Polzeta) mutagenesis pathway is a m

59 DNA polymerase zeta (Polzeta) participates in translesio

60 DNA polymerase zeta (Polzeta) promotes the mutagenic byp

61 evisiae, the contribution of the error-prone DNA polymerase zeta (Polzeta) to replication and mutagen

62 Rev7/Mad2l2 encodes a subunit of DNA polymerase zeta (Polzeta), 1 of 10 translesion DNA s

63 that include translesion synthesis (TLS) by DNA polymerases zeta (Polzeta) and Poleta and postreplic

64 We argue that DNA polymerase zeta, rather than DNA polymerase delta as

65 However, whereas the activity of DNA polymerase zeta remains unaffected by ubiquitination

66 Saccharomyces cerevisiae DNA polymerase eta, DNA polymerase zeta, Rev1 protein, and the DNA polymeras

67 athway, including translesion replication by DNA polymerase zeta/Rev1 and DNA polymerase eta, and the

68 REV1 and DNA Polymerase zeta (REV3 and REV7) play important roles

69 Together with DNA polymerase zeta (Rev3/7), Rev1 function is required

70 , which forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p.

71 Pol(kappa) is more similar to the unrelated DNA polymerase zeta than it is to the phylogenetically r

72 not only helps to coordinate the delivery of DNA polymerase zeta to a stalled primer terminus but als

73 , which encodes a subunit of the translesion DNA polymerase zeta, was responsible for the majority of

74 During translesion synthesis, eukaryotic DNA polymerase zeta (zeta) carries out extension from a