ライフサイエンスコーパス: DNA probe

1 osition of the part RNA complementary to the DNA probe.

2 n - and their incorporation onto a stem loop DNA probe.

3 nded DNA molecule with tandem repeats of the DNA probe.

4 rescence emission of the fluorescein-labeled DNA probe.

5 ition sites placed at the middle of a 300 bp DNA probe.

6 (95%) were determined to be S. pneumoniae by DNA probe.

7 (MB)-modified oligo-adenine (A)-guanine (G) DNA probe.

8 specific 16S ribosomal RNA probe and genomic DNA probe.

9 odified paper surface and negatively charged DNA probes.

10 DC/NHS chemistry for covalent conjugation of DNA probes.

11 NT surface and amine groups on the detection DNA probes.

12 the PNA probes were higher than those of the DNA probes.

13 PAM specificities for short, PAM-containing DNA probes.

14 A probes, in comparison to the corresponding DNA probes.

15 h excess fluorescently labeled complementary DNA probes.

16 can significantly enhance the performance of DNA probes.

17 ybridization of oligonucleotide sequences to DNA probes.

18 ase and were enzymatically incorporated into DNA probes.

19 d identified by the biosensor using specific DNA probes.

20 complete desorption of noncovalently linked DNA probes.

21 lized TFs with fluorescently labeled cognate DNA probes.

22 yses combined with fluorescent detection via DNA probes.

23 vities that span reported values for PNA and DNA probes.

24 ucleic acids ("targets") in solution and the DNA probes.

25 icrog/mL (1.25 fM) by adopting well-designed DNA probes.

26 hen used in comparison to unmodified labeled DNA probes.

27 of fluorescence emission from Cy5 labeled on DNA probes.

28 ility shift assays with cAMP-CRP and several DNA probes.

29 e protein-DNA complex (A complex) with short DNA probes.

30 n of small-molecule binding to surface-bound DNA probes.

31 discrimination in comparison with unmodified DNA probes.

32 ed more frequently in early periodontitis by DNA probes.

33 he species level by use of whole-chromosomal DNA probes.

34 the suspension for the digestion of multiple DNA probes.

35 ng region of mRNA to be targeted by multiple DNA probes.

36 hylene blue label on the surface-immobilized DNA probes.

37 beacons (MBs) and two single-stranded helper DNA probes.

38 s were coated with the first target-specific DNA probe 1 (1pDNA) and bio-barcode DNA, which acted as

39 The primary DNA probe (1(0)P, which was of two different sequences w

40 were coated with the second target-specific DNA probe 2 (2pDNA) that was able to recognize the other

41 using fluorescently labeled single-stranded DNA probes, a wide-field epifluorescence microscope and

42 omic hybridization with purified MIC and MAC DNA probes against a whole genome oligonucleotide microa

43 staining, cross-species chromosome painting, DNA probe analyses, and scanning electron microscopy to

44 sis of ganglioside mimics were identified by DNA probe analyses.

45 DNA probe analysis (Gen-Probe, San Diego, CA), the bile

46 was evaluated by a colony-forming assay and DNA probe analysis at different time points.

47 DNA probe analysis for 40 bacteria was used to evaluate

48 , and bacterial populations were measured by DNA probe analysis.

49 r the presence of 40 periodontal bacteria by DNA probe analysis.

50 ccupancies of the corresponding factors on a DNA probe and determining probe recovery by quantitative

51 Immobilized DNA probe and hybridized target densities on these surfa

52 The Au NP is conjugated to a DNA probe and is allowed to hybridize with the DNA targe

53 cation of anodic poles of the array with the DNA probe and its hybridization with the targets, genoty

54 Only a 4-6 bp overlap between a DNA probe and miRNA was required for efficient ligation

55 MC/Au) nanocomposite as tracing tag to label DNA probe and polythiophene (PT) as immobilization platf

56 -AC with 25 nt, Cy5 labeled DNA target and a DNA probe and study the spatiotemporal dynamics using ep

57 The hybridization between ss DNA probe and target ss DNA was detected by reduction in

58 optimized to excite a fluorophore-conjugated DNA probe and tested using real meat samples to obtain a

59 Salmonella nucleic acid (mRNA) using magneto-DNA probes and a miniaturized nuclear magnetic resonance

60 Thiolated DNA probes and alkanethiols were stably immobilised on t

61 obilization approach that is common for both DNA probes and antibodies.

62 ng pediatricians' offices were assayed by 74 DNA probes and by PCR to Streptococcus mutans.

63 ation module to perform the hybridization of DNA probes and cells/tissue samples.

64 Using a protocol based on biotinylated DNA probes and streptavidin coated magnetic beads we wer

65 Herein, interaction between DNA probes and target molecule are also investigated and

66 nce quenching and energy transfer in complex DNA probes and the choice of optimal donor/acceptor pair

67 ctionalized with two sets of single-stranded DNA probes and then used as optical probes for DNA detec

68 ucleotides or amplicon-based single-stranded DNA probes and validated the technique on three novel gu

69 y affected by the presence of guanine in the DNA probes and whether DNA is present in its single-stra

70 immobilization of the single strand DNA (ss-DNA) probe and hybridization with the target miRNA seque

71 he MWCNTs concentration, the amount of MWCNT-DNA probe, and the volume of the test probe) that govern

72 rface, (2) steric hindrance between tethered DNA probes, and (3) nonspecific adsorption of the attach

73 rter molecule, functionalized with thiolated DNA probes, and stabilized and protected by low molecula

74 e demonstrate that conditionally fluorescent DNA probes are capable of distinguishing variations of a

75 Novel fluorogenic DNA probes are described.

76 Beads coated with single-stranded DNA probes are linked to surfaces coated with single tar

77 rbon electrode, and also applying a specific DNA probe as well as hematoxylin for electrochemical ind

78 racterized amine-terminated, single-stranded DNA probes attached to amine-reactive commercial microar

79 ce was functionalized with the 24-nucleotide DNA probes based on the West Nile virus sequence (Kunjin

80 Adsorption of a fluorophore-labeled DNA probe by graphene oxide (GO) produces a sensor that

81 say that measures the relative affinities of DNA probes by determining their ability to competitively

82 le enzymatic synthesis of oligonucleotide or DNA probes by polymerase-catalyzed primer extension.

83 ates that a specially designed multistranded DNA probe can differentiate point mutations in the range

84 Split G-rich DNA probes can assemble into active peroxidase-mimicking

85 Here, we present novel magneto-DNA probes capable of rapid and specific profiling of pa

86 tion does not necessarily require the use of DNA probes centered on polymorphic nucleotides and may e

87 The study directly supports different DNA probe chemical and spatial microenvironments within

88 Sensor response to thiolated DNA probe chemisorption, hsa-let-7a hybridization, label

89 1.5 h, through specific capture with surface DNA probes combined to a 35-fold mass amplification by a

90 The control line exploits an immobilized DNA probe complementary to the labeled aptamer, forcing

91 MoS(2) flakes were modified with a thiolated DNA probe complementary to the target biomarker.

92 ved using nine distinct approximately 23-mer DNA probes complementary to regions distributed along th

93 pulations of beads, each functionalized with DNA probes complementary to the target molecule.

94 An acetylene-terminated DNA probe, complementary to a specific "Hepatitis C" vir

95 nt and susceptible RILs with U- and S-genome DNA probes confirmed that the introgression with leaf ru

96 DNA probes conjugated to AuNPs were used to detect a DNA

97 t purified YdcI protein specifically binds a DNA probe consisting of its own promoter sequence.

98 DNA probes consisting of amine-terminated oligonucleotid

99 g varied ratios of unlabeled and dye-labeled DNA probes contact-printed onto commercial arraying surf

100 hat the K protein binds to a single-stranded DNA probe containing the CT-rich element of R3, which is

101 VPA-induced binding of nuclear proteins to a DNA probe containing the relevant ARE sequence in the Ga

102 -DNA adducts in greater detail, biotinylated DNA probes containing a site-specific cisplatin 1,2-d(Gp

103 SH2-MSH6 (MutSalpha) dimer effectively bound DNA probes containing ascorbate-Cr-DNA and cysteine-Cr-D

104 sible non-covalent attachment of amphiphilic DNA probes containing hydrophobic units attached to the

105 nding experiments with circularly permutated DNA probes containing one ICP4 binding site revealed tha

106 We have developed fluorescent DNA probes containing quenched fluorophore-tetrazine and

107 Molecular beacon DNA probes, containing 1-4 pyrene monomers on the 5' end

108 Mean total DNA probe counts were similar precleaning but were highe

109 Counts, percentages of DNA probe counts, and percentages of teeth colonized for

110 he biosensor consists of a Stem-Loop DNA (SL-DNA) probe covalently attached to the gold electrode (GE

111 Optimized DNA probes demonstrated high sensitivity with excellent

112 At the low DNA probe densities typically used in assays (<10(13)/cm

113 Immobilized DNA probe density and DNA target hybridization in these

114 We also quantified the DNA probe density on electrode surface by the chronocoul

115 cumvents issues resulting from the very high DNA probe density, allowing highly enhanced hybridizatio

116 We optimized the conditions for DNA probe deposition to allow accurate detection of a we

117 n immunoprecipitation assays, KLF15 binds to DNA probes derived from the core promoter and the surfac

118 uce a novel partially double-stranded linear DNA probe design.

119 zation in situ using C0T-1 (highly repeated) DNA probes detects surprisingly abundant euchromatin-ass

120 vity of several targets with double-stranded DNA probes (dsProbes) of varying affinity.

121 Immobilization of DNA probes during pyrrole electropolymerization is a sim

122 By using a group of DNA probes, each containing a mismatched base pair or an

123 elf-assembly process and functionalized with DNA probes, enabled detection of target DNA molecules (1

124 surface chemistry influences on immobilized DNA probe environments that affect target capture effici

125 The MBI/FBI-labeled DNA probes exerted low fluorescence that was increased 2

126 assay method in which the pairs of unlabeled DNA probes firstly bind to HPV16 E6 and E7 RNAs to form

127 ntional cytogenetics and fluorescent-labeled DNA probes (fluorescence in situ hybridization [FISH]),

128 sing approaches involving aptamers, enzymes, DNA probes, fluorescent probes, interacting proteins and

129 A binary DNA probe fluorescently reports the presence of 0.5% of

130 V DNA is captured via magnetic bead-modified DNA probes, followed by an antidigoxigenin-peroxidase de

131 d with a methylene blue (MB) reporter-tagged DNA probe for DNA target detection as a model system to

132 The BD Affirm assay includes a DNA probe for Gardnerella vaginalis, the Hologic transcr

133 ontains a locked nucleic acid (LNA) modified DNA probe for improving hybridization efficiency, while

134 nique that can use specifically circularized DNA probes for detection of target nucleic acids and pro

135 achieved by introducing two short unlabeled DNA probes for each specific DNA sequence and by perform

136 strategy involving dual platforms and short DNA probes for the detection of endangered species, Mala

137 this study, we have used lanthanide-labeled DNA probes for the detection of miRNAs on membranes usin

138 ion elements such as antibodies/antigens and DNA probes for the proposition of immunosensors and geno

139 uorescence in situ hybridization with use of DNA probes for these sites demonstrates that 11q23 is cl

140 uminescence from beta-actin-specific RCA and DNA probes freely diffusing in solution or nonspecifical

141 cess of target recycling that rapidly shears DNA probes from the particles, generating an AuNP aggreg

142 We report the DNA probe functionalized electrochemical genosensor for

143 ltonics) to 16S rRNA/hsp65 sequencing and/or DNA probes (Gen-Probe) for mycobacterial identification.

144 e mismatches (SBMs) using ferrocene-modified DNA probe has been investigated in the present manuscrip

145 quantitatively against that of DNA probes or DNA probe/helper combinations directed against the same

146 Consequently, neutral ethylated DNA probe hold a great promise for DNA sensing, especial

147 ed a flap endonuclease 1 (FEN1) plus hairpin DNA probe (hpDNA) system, designated the HpSGN system, f

148 The rapid kinetics and ability to ligate DNA probes hybridized to RNA with short complementary se

149 Seventy of the 77 DNA probes hybridized with one or more of the nonamplifi

150 ngly being adopted as suitable platforms for DNA probe immobilization and signal transduction.

151 mined the optimal experimental condition for DNA probe immobilization and target interrogation.

152 A exhibited an optimum value at intermediate DNA probe immobilization densities.

153 It is demonstrated that using the E-DNA probe in the FET measurement could have a significan

154 f encoded microbeads and a high stability of DNA probes in cell-free extracts.

155 with sequence specific capture and labeling DNA probes in solution and then the complex is pulled do

156 Thus, we can report the development of DNA probes in the form of photon-controllable (thrombin)

157 ent to recruit LHP1 to GAGA motif-containing DNA probes in vitro.

158 d excimer formation of pyrenes, and modified DNA probes, incorporating two pyrene deoxynucleotides an

159 r or during (real-time monitoring) dye or Ln DNA probe incubation and could efficiently distinguish b

160 r finding that a fluorophore inserted into a DNA probe instead of one of the internal nucleotides may

161 We further revealed and quantified fast DNA probing interactions that last shorter than 10 ms.

162 In this proposed strategy, a dumbbell-shaped DNA probe is designed to integrate target binding, magne

163 The molecular extension of thousands of DNA probes is determined with sub-micron precision using

164 AMs has revealed that the surface density of DNA probes is highly dependent on the composition of the

165 This assay consists of a linear DNA probe labeled with a fluorophore in the middle.

166 ast, Saccharomyces cerevisiae using a single DNA probe labeled with a single fluorophore.

167 d with a capture DNA sequence and a reporter DNA probe labeled with the enzyme, both made to be highl

168 ins with the covalent conjugation of capture DNA probe labeled with thiol at its 3'terminal onto the

169 Single-stranded DNA probes labeled with fluorescein amidite (FAM-ssDNA),

170 it notably gave a false-positive Blastomyces DNA probe laboratory result.

171 robe, the size of Au-NP, the amount of Au-NP-DNA probe, lateral flow membranes, and the concentration

172 face capture produced by MCU addition to the DNA probe layer correlates with structural and conformat

173 bsequent signal amplification by a secondary DNA probe linked to AuNS.

174 We designed phosphorothioate-modified DNA probes linked to superparamagnetic iron oxide nanopa

175 ly, a novel species-specific electrochemical DNA probe (locked nucleic acid, LNA) was synthesized and

176 Importantly, we have reproduced DNA probe microarray immobilization densities in macrosc

177 complex (B complex) formed by ICP4 with long DNA probes migrates just behind the A complex in the ele

178 pe hybridization reactions among GNP-labeled DNA probe, miRNA-215 and biotin-modified DNA probes were

179 s performed in a single tube with one set of DNA probe-modified gold nanoparticles (AuNPs), a single

180 ical methods and compared for morpholino and DNA probe monolayers.

181 idization events occurred among biotinylated DNA probes, mutant DNA, and complementary DNA, the resul

182 cases reflects an aggregate affinity for the DNA probes, not the affinity for binding to a single sit

183 The DNA probe of atxA gene efficiently hybridizes with diffe

184 target by using two different newly designed DNA probes of IS711 gene.

185 sensitivity approximately 4-fold compared to DNA probes of the same sequence.

186 bilized single stranded thiolated DNA (ss th-DNA) probe of N. meningitides onto the nanostructured Zn

187 t immobilization of purified single-stranded DNA probe oligomers on cleaned gold microelectrodes.

188 n is specific and selective for atxA gene by DNA probe on the electrode surface.

189 The method of non-covalent immobilization of DNA probes on an uncharged, non-reactive, hydrophilic su

190 rescence intensity results using end-labeled DNA probes on gold show little observable fluorescence o

191 In this work, the immobilization of DNA probes on nanostructured metal-dielectric/semiconduc

192 s was applied to check the immobilization of DNA probes on pretreated samples.

193 ty of different types of hybrids formed with DNA probes on surfaces is affected by probe spacing.

194 roRNAs can form DNA: RNA heteroduplexes with DNA probes on the surface of AuNPs, which can be hydroly

195 pad and the dispensing cycles of the capture DNA probes on the test-zone), the biosensor could detect

196 This assay uses a pair of specific DNA probes, one being covalently conjugated to an MNP fo

197 Target DNA serves as a template for two DNA probes, one of them covalently attached to upconvers

198 was compared quantitatively against that of DNA probes or DNA probe/helper combinations directed aga

199 sDNA density had a profound influence on the DNA probe orientation at the surface and subsequent targ

200 2 to efficiently join adjacent chimeric RNA-DNA probe pairs hybridized in situ on fixed RNA target s

201 Most reported fluorescent sensors relied on DNA probes physisorbed by GO, which may suffer from nons

202 , self-complementary, methylene blue-labeled DNA probe possessing a triple-stem structure.

203 Using an optimized process of DNA probe preparation to minimize the effect of contamin

204 bridization of the AIV H5 capture and target DNA probes produced a capacitance reduction of -13.2 +/-

205 cence activation in which a phosphine on one DNA probe reduces an azide group in a linker on a second

206 identify proteins that interact with RNA and DNA, probe regions of DNA hypersensitivity, and measure

207 teins for O(2)-nBudT- and O(4)-nBudT-bearing DNA probes, respectively.

208 poration of the CF3-(Ph)ImdC analogue into a DNA probe resulted in 6-fold fluorescence quenching of t

209 of locked nucleic acid (LNA) residues in the DNA probes resulted in greater discrimination between ex

210 olates also resulted in positive Blastomyces DNA probe results, while Spiromastigoides species other

211 The hybridization of the DNA target with the DNA probes results in instantaneous aggregation of AuNPs

212 s used as a detection technique coupled with DNA probe sandwich assemblies and gold nanoparticles (GN

213 DNA probes separated by as little as 50 kb can be resolv

214 alent immobilization of the thiol-terminated DNA probe sequence (pDNA) using displacement reaction is

215 hybridization properties of a 15-nucleotide DNA probe sequence that has additional m adenine nucleot

216 ned and fabricated to covalently attach both DNA probing sequence and nonfluorescent Raman tags to th

217 ing polymer that is covalently modified with DNA probe sequences.

218 The population of immobilized DNA probe sites is quantified by counting individual DNA

219 e tuned by simply changing the length of the DNA probe (six (A6) or 12 (A12) adenines).

220 sing high ionic strength, high-concentration DNA probe solutions to permit direct XPS surface analysi

221 sing two pairs of unique capture- and signal-DNA probes specific for each target.

222 e d-AuNPs were stabilized by single stranded DNA probe (ssDNAp).

223 Fluorescently labeled DNA-probe strands are immobilized on PEGylated gold nano

224 On surfaces, when immobilized MO or DNA "probe" strands hybridize with complementary DNA "ta

225 n the prominent features of NEases, modified DNA probes (such as hairpin (HP) probes, molecular beaco

226 nd fluorometric quantification of a desorbed DNA probe suggest that DNA permeation is severely limite

227 ybridization reactions among the FCN-labeled DNA probe, target DNA and capture DNA probe were perform

228 DNA probes targeting these antigens were designed and ev

229 DNA sensor based on the use of a clamp-like DNA probe that binds a complementary target sequence thr

230 Here, we show a novel DNA probe that can transduce transient membrane encounte

231 A secondary DNA probe that contained 36 bases with alkaline phosphat

232 nsor involved the immobilization of a 17-mer DNA probe that is complementary to a specific gene seque

233 isplacement of micron-size beads tethered by DNA probes that are between 1 and 7 microns long.

234 The surface consists of single-stranded DNA probes that are covalently anchored to a self-assemb

235 e enhanced local effective concentrations of DNA probes that are involved in PiDSD, and identified a

236 ides to preferentially and irreversibly bind DNA probes that are mechanically strained over probes at

237 mobilization on a surface of single-stranded DNA probes that bind complementary targets in solution.

238 an be amplified to yield small (100-2000 bp) DNA probes that in aggregate will generate a single, str

239 GMR sensor is functionalized with synthetic DNA probes that target methylated or unmethylated CpG si

240 e 3'-OH of target strands that hybridized to DNA probes that were printed on a surface.

241 nS) were synthesized and functionalized with DNA probes that were specific to each pathogen.

242 This resulted in adsorptively bound DNA-probes that were used to detect complementary, label

243 ated it to one terminus of a single-stranded DNA "probe" that was attached by its other terminus via

244 fect of contaminants in commercial thiolated DNA probe, the electrode surface was functionalized with

245 implicity of ELISA, and the specificities of DNA probes, this method rapidly detected and differentia

246 interface of the biosensor by surface-bound DNA probes through a hybridization process.

247 odify a gold electrode for immobilization of DNA probes through the Schiff base reaction.

248 we have optimized the concentrations of the DNA probe to decrease the hybridization time to 10 min.

249 r, no attempt has yet been made to conjugate DNA probe to Fe3O4/TMC/Au nanocomposite as electrochemic

250 ionalized gold nanoparticles and fluorescent DNA probes to capture target DNA in free solution, and w

251 rammable and specific binding of dye-labeled DNA probes to count integer numbers of targets.

252 technique, which uses fluorescently labeled DNA probes to detect chromosomal alterations in cells, o

253 HyPR-seq involves hybridizing DNA probes to RNA, distributing cells into nanoliter dro

254 ences via sandwich hybridization of specific DNA probes to the target sequence.

255 0 A chromosome pairs by FISH using the yeast DNA probe together with a karyotyping cocktail.

256 ning buffers, the concentration of detection DNA probe used in the preparation of FCN-DNA conjugates,

257 deletion and that the confusion is caused by DNA probes used in the experiment.

258 lected based on low Blastomyces dermatitidis DNA probe values and/or atypical morphology.

259 ic acid (MPA) for immobilization of specific DNA probe via avidin layer on the surface.

260 nvolves attachment of a biotinylated primary DNA probe via its 5'-amine-terminus to the streptavidin-

261 oelectrodes is exploited to bind the capture DNA probes via amide coupling with the carboxylic groups

262 The np-Au electrodes modified with 26-mer DNA probes (via thiol-gold chemistry) enabled sensitive

263 Afterward, the single-stranded DNA probe was attached to the surface of AuNUs on the mo

264 This DNA probe was characterized and used in photo-cross-link

265 A capture DNA probe was immobilized on the test zone of the latera

266 The DNA probe was initially designed to have a complementary

267 A specific E. faecalis DNA probe was selected from 16S rRNA sequence of E. faec

268 One DNA probe was tagged with fluorescein; the other was bio

269 endent binding of RcoM(Bx)-1 to a variety of DNA probes was demonstrated in vitro.

270 2-mul usage for FISH deoxyribonucleic acid (DNA) probe was used, which is five-fold reduction when c

271 R assay, using a FAM labeled double quenched DNA probe, was at least 40x more sensitive than the TaqM

272 Using a "U"-shaped DNA probe, we report that DNA bending by charged bZIP pe

273 CN-labeled DNA probe, target DNA and capture DNA probe were performed on the lateral flow biosensor.

274 omplementary DNA target with the immobilized DNA probes were calculated by using kinetic evaluation s

275 Eighteen different 50-mer single-stranded DNA probes were covalently attached to 3.1-mum microsphe

276 DNA probes were covalently attached to the waveguide sur

277 Specific DNA probes were designed and used in real-time PCR assay

278 Eight 100-nucleotide single-stranded DNA probes were designed complementary to the E6-E7 gene

279 In MQDS, pathogen specific DNA probes were designed to form a hairpin structure and

280 Capture and detection DNA probes were designed.

281 terial in the biosensors and biochips field, DNA probes were electrografted, using diazonium chemistr

282 led DNA probe, miRNA-215 and biotin-modified DNA probes were performed on the lateral flow device.

283 Biotinylated capture DNA probes were then attached to the detection antibodie

284 Six near-identical DNA probes were used in this study; the main differences

285 In this approach, short DNA probes were utilized to first quantify the amount of

286 lternative strategy for surface tethering of DNA probes, where highly reactive glassy carbon (GC) sub

287 ily accessible to tiled 8-mer LNA and 15-mer DNA probes, whereas an unmodified version of the same DN

288 exing approach based on the fast exchange of DNA probes which enables efficient and rapid multiplexed

289 n using gold nanoparticles conjugated with a DNA probe, which is complementary to the 16S ribosomal R

290 15nm was used as a tag to label a detection DNA probe, which was complementary with the part of targ

291 detect the hybridization of single stranded DNA probe with its complementary target strand.

292 ination efficacy and detection capacity of a DNA probe with two inserted UNA monomers (UNA2), and com

293 UNA monomers (UNA2), and compared it to the DNA probe with two purposefully inserted mutations (DNAM

294 TP-2Bzim, TP-3Bzim) are light-up fluorescent DNA probes with a long wavelength emission (>580 nm).

295 uential liquid hybridization of biotinylated DNA probes with mutant DNA and complementary DNA, the re

296 The assembly of libraries containing DNA probes with specific modifications and the availabil

297 orster resonance energy transfer (FRET) dual DNA probes with the excimer-forming pyrene pair as a don

298 two dyes provides a simple method to prepare DNA probes with unique fluorescent signatures.

299 It can be used as a luminescent DNA probe, with emission switched on through DNA binding

300 ity is achieved with polynucleotide-extended DNA probes, with the unzipping of a miRNA-DNA duplex in