ライフサイエンスコーパス: DNA rearrangement

1 hat transcription is important for efficient DNA rearrangement.

2 ernal element DNA is not required in cis for DNA rearrangement.

3 cell process that involves intrachromosomal DNA rearrangement.

4 ve evolved by gene duplication, mutation and DNA rearrangement.

5 y an unusual head-to-head dimer with complex DNA rearrangement.

6 ic means to establish a heritable pattern of DNA rearrangement.

7 ation (NAHR) is one of the key mechanisms of DNA rearrangement.

8 red for prethymic lymphoid commitment or for DNA rearrangement.

9 ized regions, often associated with sites of DNA rearrangement.

10 result from a duplication event followed by DNA rearrangement.

11 xchange, resulting in frequent and extensive DNA rearrangement.

12 o provide a template for correct and precise DNA rearrangement.

13 ntly unrecognized zones of susceptibility to DNA rearrangement.

14 me after which the parental genome can block DNA rearrangement.

15 es for chromatin modification and subsequent DNA rearrangement.

16 amily of tyrosine recombinases that catalyze DNA rearrangements.

17 her topoisomerases and proteins that perform DNA rearrangements.

18 A and must reflect also solvent and possibly DNA rearrangements.

19 developing somatic macronucleus by specific DNA rearrangements.

20 iosynthesis but appears to be a hot spot for DNA rearrangements.

21 and in productive and non-productive genomic DNA rearrangements.

22 th 3' and 5' strands without massive protein/DNA rearrangements.

23 e xisHI genes had no effect on the two other DNA rearrangements.

24 gests the evolutionary conservation of these DNA rearrangements.

25 ly generated by short-homology-repeat-driven DNA rearrangements.

26 ermini, with implications for DNA repair and DNA rearrangements.

27 very close to the site of wheat/Arabidopsis DNA rearrangements.

28 ements that are engineered to cause specific DNA rearrangements.

29 at can trigger replication fork collapse and DNA rearrangements.

30 play a significant role in triggering these DNA rearrangements.

31 nes in B lineage cells involves two distinct DNA rearrangements.

32 icer-related gene is required for programmed DNA rearrangements.

33 lity factors that control integrase-mediated DNA rearrangements.

34 ipts in combination with evidence for D-J(H) DNA rearrangements.

35 s, the disease phenotype was linked to gross DNA rearrangements (35 and 85 kb deletions and a translo

36 demonstrating the distribution of permanent DNA rearrangements across major NK cell subsets in man.

37 Chromosomal translocations or DNA rearrangements affecting c-myc occur in almost all m

38 ent absence of chromosomal translocations or DNA rearrangements affecting c-myc.

39 s been extensive and sometimes rather recent DNA rearrangement among a number of the linear plasmids.

40 suggest an expanding paradigm of programmed DNA rearrangements among microorganisms.

41 suggest an expanding paradigm of programmed DNA rearrangements among microorganisms.

42 a primary mechanism that accelerates genomic DNA rearrangement and amplification into ecDNA and enabl

43 on in the tla2 strain, causing a chromosomal DNA rearrangement and deletion/disruption of five nuclea

44 e-leucine-rich repeat) genes and accelerated DNA rearrangement and gene loss, confer a striking resem

45 cial chromosomes and undergo B-cell-specific DNA rearrangement and hypermutation in the mouse lymphoi

46 y documented and suggests a process of viral DNA rearrangement and loss during malignant progression

47 s information suggested a novel mechanism of DNA rearrangement and raised interesting questions regar

48 NA transport and translational regulation to DNA rearrangement and repair.

49 ments resulted in reproducible mitochondrial DNA rearrangements and a condition of male (pollen) ster

50 R) repertoires are generated through somatic DNA rearrangements and are responsible for the molecular

51 R) repertoires are generated through somatic DNA rearrangements and are responsible for the molecular

52 mbination (HR) deficiency is associated with DNA rearrangements and cytogenetic aberrations(1).

53 onjugating cells during the time of germline DNA rearrangements and degradation.

54 Sequence comparison revealed numerous DNA rearrangements and mutations in SCCcap1 and the left

55 nes exhibited multiple transgene and genomic DNA rearrangements and regions of scrambling characteris

56 istinct constellations of somatic structural DNA rearrangements and sequence mutations that commonly

57 RNA-based mechanism that directs genomewide DNA rearrangements and serves to disable invading geneti

58 nt (48 kb) is excised from the chromosome by DNA rearrangement, and a composite gene, sigK (spoIIIC a

59 ping genomes, thereby regulating genome-wide DNA rearrangement, and that these sRNAs can be effective

60 ion of RAG gene expression, light chain gene DNA rearrangements, and expression of lambda-light chain

61 may offer resilience to mutation, including DNA rearrangements, and facilitate the adaptation of T4-

62 aments, the active species in uvsX-catalyzed DNA rearrangements, apparently by helping uvsX displace

63 These DNA rearrangements are commonly found in genic intervals

64 Programmed DNA rearrangements are critical for the development of m

65 of this process has led to speculation that DNA rearrangements are used to limit the expression of o

66 However, extensive DNA rearrangements arising through a series of mutations

67 rt in Nature directly rules out irreversible DNA rearrangements as a mechanism for odorant receptor g

68 in the budding yeast Kluyveromyces lactis, a DNA rearrangement associated with mating type switching

69 ll been put forward as mechanisms to explain DNA rearrangements associated with genomic disorders.

70 f the human genome are known to give rise to DNA rearrangements associated with many genetic disorder

71 isruption leads to the type of mitochondrial DNA rearrangements associated with naturally occurring c

72 assay to identify rare homology-independent DNA rearrangements associated with repair of a chromosom

73 havior that involves a significant amount of DNA rearrangement at telomeres and suggest that length r

74 As a first step towards mediating directed DNA rearrangements at non-native Flp recombination targe

75 f modular enzymes that promote high-fidelity DNA rearrangements between specific target sites.

76 nstrate that the defect lies at the level of DNA rearrangements between the Ig switch regions.

77 y topoisomerase IV, which are intramolecular DNA rearrangements but not decatenation of multiply link

78 ale-sterile (CMS) mutants have mitochondrial DNA rearrangements, but they are impaired for mitochondr

79 Serine recombinases promote specific DNA rearrangements by a cut-and-paste mechanism that inv

80 specifically select for switches mediated by DNA rearrangements by inducing VSG RNAi in the presence

81 t regulatory proteins underlines how modular DNA rearrangements can evolve by serving pathogen divers

82 oth direct and inverted repeats, which allow DNA rearrangements, deletion, or duplication; these elem

83 Rather, we found that, whereas illegitimate DNA rearrangement did not play a major role in the devel

84 These DNA rearrangements do not include the putative origin of

85 perform extreme forms of programmed somatic DNA rearrangement during development.

86 trichs, most genes undergo several layers of DNA rearrangement during macronuclear development.

87 mmonly harbor PTCs as a result of programmed DNA rearrangement during normal development, are down-re

88 CMT1A-REP and the creation of novel genes by DNA rearrangement during primate speciation.

89 a are dynamic structures, undergoing massive DNA rearrangement during the formation of a functional m

90 plants, nuclear genes suppress mitochondrial DNA rearrangements during development.

91 Ciliated protozoa carry out remarkable DNA rearrangements during nuclear differentiation, inclu

92 s by which feedback repression of sequential DNA rearrangements ensures that only one autosome expres

93 ringently-regulated coordination of specific DNA rearrangement events across several large chromosoma

94 posases are ubiquitous enzymes that catalyze DNA rearrangement events with broad impacts on gene expr

95 tween physiological stress and activation of DNA rearrangement functions.

96 A novel DNA rearrangement has been characterised that is both a

97 NA sequences; however, the mechanism of such DNA rearrangements has yet to be elucidated.

98 ng issues of frequency, site preference, and DNA rearrangement in human as well as animal cells.

99 may provide insights into the mechanisms of DNA rearrangement in other disorders.

100 ase family whose members are responsible for DNA rearrangement in prokaryotes, eukaryotes and viruses

101 Class switch recombination (CSR) involves a DNA rearrangement in the Ig heavy chain (IgH) gene that

102 posase by RNA interference leads to abnormal DNA rearrangement in the offspring.

103 ecombinases that catalyze a diverse array of DNA rearrangements in archaebacteria, eubacteria, and ye

104 Somatic DNA rearrangements in B lymphocytes, including V(D)J gen

105 vide a plausible mechanism for site-specific DNA rearrangements in childhood and adult solid tumors.

106 ic mechanism for the generation of oncogenic DNA rearrangements in childhood cancer.

107 is developmental limitation could be somatic DNA rearrangements in differentiating neural cells.

108 omosome 19 element, which is responsible for DNA rearrangements in episomes propagating AAVS1 DNA, wa

109 lin and T-cell receptor genes, which undergo DNA rearrangements in lymphocytes.

110 via a unique restricted set of site-specific DNA rearrangements in lymphoid cells, known as V(D)J rec

111 ted repeats, a sequence motif known to cause DNA rearrangements in model organisms.

112 othesis that OR gene choice is controlled by DNA rearrangements in OSNs.

113 mplates provide both an organizing guide for DNA rearrangements in Oxytricha and a template that can

114 Ig DNA rearrangements in plasma may be useful as a lymphoma

115 The RAG1/2 endonuclease initiates programmed DNA rearrangements in progenitor lymphocytes by generati

116 ere also sufficient to mediate PGBD5-induced DNA rearrangements in rhabdoid tumor cells.

117 The models are applied to explain DNA rearrangements in some groups of ciliates, such as S

118 son-like structure, Tlr1 is similar to other DNA rearrangements in Tetrahymena in possessing cis -act

119 Treatment just before DNA rearrangements in the developing macronuclei (anlage

120 sequences, and the fundamental importance of DNA rearrangements in the evolution of sequenced genomes

121 Programmed DNA rearrangements in the single-celled eukaryote Oxytri

122 xin at the locus increases the likelihood of DNA rearrangements in this region.

123 mbination has been used to introduce desired DNA rearrangements in various organisms, having for exam

124 e RAG proteins mediate two other alternative DNA rearrangements in vivo: the rejoining of signal and

125 ces from this 1.4-kb region revealed diverse DNA rearrangements, including an inversion, several dele

126 Programmed DNA rearrangements, including DNA diminution, characteri

127 DNA rearrangements, including insertions, deletions, and

128 unified mechanism for the three fundamental DNA rearrangements-insertion, excision and inversion-tha

129 These DNA rearrangements involve cleavage by the RAG1 and RAG2

130 t for variation C. fetus uses a mechanism of DNA rearrangement involving inversion of a 6.2 kb segmen

131 hereditary elliptocytosis 4.1Alg, in which a DNA rearrangement involving the exon containing the down

132 Examining potential DNA rearrangements involving the cagY repeats indicated

133 ases are recognized to result from recurrent DNA rearrangements involving unstable genomic regions.

134 ptor (TCR) repertoires, generated by somatic DNA rearrangements, is central to immune system function

135 cer genomes often harbor hundreds of somatic DNA rearrangement junctions, many of which cannot be eas

136 end processing during the lymphoid-specific DNA rearrangement known as V(D)J recombination, defectiv

137 These programmed DNA rearrangements make this a fascinating system of mat

138 Results from these DNA rearrangements may help explain the CTD copy number

139 ic nuclei through a sophisticated programmed DNA rearrangement mechanism, resulting in the eliminatio

140 itana NS-E has revealed numerous large-scale DNA rearrangements, most of which are associated with CR

141 s similarly indicated that not all three het DNA rearrangements need to reside on a composite molecul

142 H2A.X is phosphorylated when programmed DNA rearrangements occur in developing macronuclei, as f

143 Genome-wide DNA rearrangements occur in many eukaryotes but are most

144 Genomewide DNA rearrangements occur in many eukaryotes during devel

145 Mitochondrial DNA rearrangements occur very frequently in flowering pl

146 uthern blot analysis showed that chromosomal DNA rearrangements occurred in the 1363mel cell line.

147 us is communicated to the other, we assessed DNA rearrangement occurring in wild-type cells that were

148 Additionally, a second mechanism of DNA rearrangement occurs to replace at least one of the

149 B-lymphocyte development involves sequential DNA rearrangements of immunoglobulin (Ig) heavy (mu) and

150 uence breakpoints recurrently affect somatic DNA rearrangements of known tumor suppressors and oncoge

151 We have observed a number of DNA rearrangements of the T4 genome type, some exhibitin

152 breaking-and-rejoin type mechanism to affect DNA rearrangement on specific DNA sequences.

153 e unstable, suggesting a possible reversible DNA rearrangement or an epigenetic change in the lss mut

154 alterations in genome organization caused by DNA rearrangements or genome size expansion.

155 from an M71-expressing OSN, does not reveal DNA rearrangements or sequence alterations at the M71 lo

156 Although no DNA rearrangements or sequence differences in the 5' reg

157 c/Ds transposable elements often leave short DNA rearrangements, or 'footprints,' at the sites where

158 ion of artificial templates reprogrammes the DNA rearrangement pathway, suggesting that RNA molecules

159 DNA rearrangement permits bacteria to regulate gene cont

160 This extra layer of DNA rearrangement permits novel mechanisms to create gen

161 that much of the polymorphism may be due to DNA rearrangements, possibly resulting from the insertio

162 eptor genes are assembled by a site-specific DNA rearrangement process called V(D)J recombination.

163 refore, V(D)J recombination, a physiological DNA rearrangement process, activates the ATM/p53 pathway

164 The site-specific DNA rearrangement process, called V(D)J recombination, c

165 f Pdd2p leads to the perturbation of several DNA rearrangement processes in developing zygotic macron

166 enabled by MAGIC advances the dissection of DNA rearrangement processes, shedding light on fundament

167 in Tetrahymena thermophila requires several DNA rearrangement processes.

168 tep strand refolding is a novel mechanism in DNA rearrangement reactions.

169 eurogenic processes might involve aspects of DNA rearrangement, recent discoveries about the unusual

170 hese results can be explained by a model for DNA rearrangement (recombination) involving DNA replicat

171 DNA rearrangement (recombination) mediated by direct rep

172 s in a hypermutation phenotype likely due to DNA rearrangements, reflected in the rapid appearance of

173 Relocalization occurred in response to a DNA rearrangement replacing a boundary element (IR-R) wi

174 Switching the active VSG gene can involve DNA rearrangements replacing the old VSG with a new one,

175 n cancer, conventional methods for detecting DNA rearrangements require laborious indirect assays.

176 inked DNA dimers, which is an intermolecular DNA rearrangement required for proper segregation of dau

177 a class of diseases that are associated with DNA rearrangements resulting from region-specific genome

178 DNA rearrangements resulting in human genome structural

179 ActiD molecules to G:G mismatch sites causes DNA rearrangements, resulting in backbone distortion to

180 rthermore, our characterization of this rare DNA rearrangement revealed a more common result of the m

181 sis for BV10 and BV19 transcripts and thymic DNA rearrangements revealed no such selection of in-fram

182 have increased numbers of somatic structural DNA rearrangements, some of which carry PGBD5-specific s

183 The DNA rearrangement steps during WHO element homing are ve

184 enomenon is mechanistically related to other DNA rearrangements such as V(D)J recombination and retro

185 ic disorders are conditions that result from DNA rearrangements, such as deletions or duplications.

186 enomenon is mechanistically related to other DNA rearrangements, such as V(D)J recombination and retr

187 endonuclease thus seems more appropriate for DNA rearrangements than for restriction.

188 P expression occurs by a mechanism of nested DNA rearrangement that involves the inversion of a 6.2-k

189 es through a series of site-specific somatic DNA rearrangements that are collectively called variable

190 Paradoxically, the types of DNA rearrangements that are specifically associated with

191 ectural features result in susceptibility to DNA rearrangements that cause disease.

192 Such events can result in DNA rearrangements that cause disease.

193 has considerable flexibility in the types of DNA rearrangements that it can promote.

194 enerate and has neglected the effects of the DNA rearrangements that lead to their formation.

195 act that all ciliates share similar forms of DNA rearrangement, there appears to be great diversity i

196 ric epithelium and possible contributions of DNA rearrangements to genome evolution.

197 Protein catalyzed DNA rearrangements typically require assembly of complex

198 V(D)J recombination is the specialized DNA rearrangement used by cells of the immune system to

199 amily of site-specific recombinases catalyze DNA rearrangements using phosphoryl transfer chemistry t

200 gle non-replicative IS10 element can promote DNA rearrangements usually attributed to replicative tra

201 reaks generated during the lymphoid-specific DNA rearrangement, V(D)J recombination, which is require

202 naplastic Large Cell Lymphoma (ALCL) line, a DNA rearrangement was detected within the hrgr gene regi

203 By directly following Flp-mediated DNA rearrangements we have analyzed the adult expansion

204 ch for new factors involved in developmental DNA rearrangement, we identified two Twi1p-interacting p

205 To define requirements for DNA rearrangement, we performed mutagenesis of the M ele

206 2 (RAG-2) expression and endogenous V-Jkappa DNA rearrangements were found.

207 However, Pim1 DNA rearrangements were frequently sub-stoichiometric an

208 As short-range DNA rearrangements were not detected, giardial VSP switc

209 Frequent DNA rearrangements were observed in the CEN8 region, inc

210 The FGF-4 gene was truncated by DNA rearrangement with a novel gene named GRS.

211 pable of predicting the rates of large-scale DNA rearrangements within a factor of 2.

212 ic recombinases that catalyze intermolecular DNA rearrangements without energetic input.