ライフサイエンスコーパス: DNA virus

1 oductive infection of this large cytoplasmic DNA virus.

2 highly structurally complex double stranded DNA virus.

3 of both is needed to control infection by a DNA virus.

4 igation of the oncogenic mechanisms for this DNA virus.

5 etect both siRNAs and a novel miRNA from the DNA virus.

6 end of the Rep ORF in the unclassified CRESS DNA virus.

7 everse-transcribing and single-stranded (ss) DNA viruses.

8 rable to that of qPCR for transplant-related DNA viruses.

9 a key role in the transcriptional control of DNA viruses.

10 intrinsic restriction mechanism acting upon DNA viruses.

11 s a family of small circular single-stranded DNA viruses.

12 tly belonging to the nucleocytoplasmic large DNA viruses.

13 f antiviral activity against a wide range of DNA viruses.

14 proach as a treatment for diseases caused by DNA viruses.

15 or RNA viruses whereas PVG PCR detected more DNA viruses.

16 innate immune response to exogenous DNA and DNA viruses.

17 uction by a panel of pathogenic bacteria and DNA viruses.

18 obustly induced upon infection with multiple DNA viruses.

19 in that can be found in many double-stranded DNA viruses.

20 sponses against RNA viruses, but not against DNA viruses.

21 ral drugs for the treatment of infections by DNA viruses.

22 s of the protein kinase R pathway with large DNA viruses.

23 o cytosolic DNA, c-di-GMP, cGAMP, HIV-1, and DNA viruses.

24 the host innate immune response to HIV-1 and DNA viruses.

25 us expands our knowledge of the diversity of DNA viruses.

26 o largely take over study of double-stranded DNA viruses.

27 STING to initiate the antiviral response to DNA viruses.

28 s antiviral activity against several RNA and DNA viruses.

29 thod is not effective against phloem-limited DNA viruses.

30 ba species are infected by the largest known DNA viruses.

31 replication intermediates produced by other DNA viruses.

32 stant to geminiviruses, a damaging family of DNA viruses.

33 f the suitability of bone for exploration of DNA viruses.

34 cellular immune response to infections with DNA viruses.

35 disease caused by several pathogenic RNA and DNA viruses.

36 riched metagenomics largely identifying more DNA viruses.

37 lective increase was not observed with other DNA viruses.

38 mplex transcriptomes typical of many RNA and DNA viruses.

39 onserved function of Toll in defense against DNA viruses.

40 olved in suppressing the replication of many DNA viruses.

41 nes were identified in large double-stranded DNA viruses.

42 plication in the absence of B1, unlike other DNA viruses.

43 mes have evolved via parvoviruses from CRESS-DNA viruses.

44 protein (ZAP) inhibits a variety of RNA and DNA viruses.

45 leave us with a lesser understanding of how DNA viruses adapt to hosts and how the host responds to

46 dynamics and identify genes that are key to DNA virus adaptation, improving our understanding of how

47 and mammalian reservoir hosts of 415 RNA and DNA viruses along with their histories of human infectio

48 infections is no greater than that of other DNA viruses analyzed by the same sequencing and bioinfor

49 s have deficient inflammasome responses to a DNA virus and fungal infection.

50 The virus is a large DNA virus and is the only member of the Asfarviridae fam

51 Other DNA viruses and cellular DNA are likely to encounter sim

52 osely classed into two groups: slow-evolving DNA viruses and fast-evolving RNA viruses.

53 ontaining proteins are encoded by many large DNA viruses and found in all domains of life, studies of

54 a total of 77 632 integration sites of five DNA viruses and four RNA retroviruses.

55 IMPORTANCE Alphaherpesviruses are ubiquitous DNA viruses and include the human pathogens herpes simpl

56 S)) in protein-coding genes of human RNA and DNA viruses and mammals.

57 origin of several groups of large eukaryotic DNA viruses and self-replicating plasmids.

58 ead of an engineered trait in populations of DNA viruses and, in particular, herpesviruses.

59 a gene conserved in nucleo-cytoplasmic large DNA viruses) and Organic Lake virophage OLV2 (conserved

60 e limited encoding capacity compared to many DNA viruses, and as a likely consequence, most open read

61 us of Mice (MVM), both T = 1 single stranded DNA viruses, and Bromo Mosaic Virus (BMV), a T = 3 singl

62 ery of 24 novel marsupial-associated RNA and DNA viruses, and that viral diversity is lower in captiv

63 , large systems including protein binding to DNA, viruses, and membranes.

64 umber of sequences (P = 0.047) of persistent DNA viruses (anelloviruses, herpesviruses, papillomaviru

65 Similarly, the rep genes of prokaryotic DNA viruses appear to have evolved from HUH endonuclease

66 recognized by RIG-I during infection with a DNA virus are largely unknown.

67 Single-stranded (ss) DNA viruses are a major component of the earth virome.

68 covirus species, ten of the identified CRESS DNA viruses are assigned to the genera Porprismacovirus

69 Infections with DNA viruses are frequent causes of morbidity and mortali

70 Several DNA viruses are highly suspicious to have oncogenic effe

71 Various types of DNA viruses are known to elicit the formation of a large

72 A number of DNA viruses are known to manipulate sncRNA either by enc

73 Prior studies have suggested that insect DNA viruses are negatively affected by dicer-2-mediated

74 Single-stranded DNA viruses are, however, highly diverse and pervasive a

75 However, induction is not restricted to DNA virus, as sindbis virus, an RNA virus, enhances the

76 ge dsDNA viruses.IMPORTANCE Unlike all other DNA viruses, ascoviruses code for an executioner caspase

77 clusion that a densovirus is the predominant DNA virus associated with this syndrome and, thus, the m

78 viruses 1 and 2 (HSV-1 and HSV-2) are large DNA viruses associated with recurring oral or genital er

79 s antiviral activity against several RNA and DNA viruses, associates with the endoplasmic reticulum (

80 s in GT frequencies have been achieved using DNA virus-based replicons.

81 s (STING) is known be involved in control of DNA viruses but has an unexplored role in control of RNA

82 substitution rate is surprisingly high for a DNA virus, but lower than that of other reverse transcri

83 h in vitro activity against HHV-6B and other DNA viruses, but its in vivo activity for HHV-6B has not

84 lyzing motor, formed in many double-stranded DNA viruses by a complex of a small terminase (S-termina

85 These results suggest that a nuclear DNA virus can selectively interfere with RNA export to r

86 litis in susceptible mice.IMPORTANCE RNA and DNA viruses can cause encephalitis; in some cases, this

87 Whether DNA viruses can prevent activation of the cGAS-STING pat

88 uman cytomegalovirus (HCMV), like many other DNA viruses, can cause genome instability and activate a

89 Hepatitis B virus (HBV), a small enveloped DNA virus, chronically infects more than 350 million peo

90 nt a global map of abundant, double-stranded DNA viruses complete with genomic and ecological context

91 For many double-stranded DNA viruses, confinement of the large DNA molecule withi

92 50 residual plasma samples with at least one DNA virus detected in prior clinical testing showed a to

93 otein (Rep) encoding single-stranded (CRESS) DNA viruses detected in the faeces of Zambian non-human

94 Our results provide a glimpse into how DNA viruses differ from RNA viruses in their evolutionar

95 ing of bacteriophages and eukaryotic RNA and DNA viruses, during the first years of life.

96 The CRESS-DNA viruses emerged via recombination between such plasm

97 , our data provide the first evidence that a DNA virus evades host innate immunity by encoding an RNA

98 uently identified drivers of double-stranded DNA viruses evolution.

99 ncer-selective cell death.IMPORTANCE Several DNA viruses evolved mechanisms to inhibit the cellular D

100 that the replication machinery of the CRESS-DNA viruses evolved, on three independent occasions, fro

101 Accordingly, Nlrx1(-/-) mice infected with DNA viruses exhibit enhanced innate immunity and reduced

102 human cytomegalovirus (HCMV), a large human DNA virus, exploits IFITMs to facilitate the formation o

103 rom veterinary herpesviruses and other large DNA virus families.

104 he ubiquitous human circular single-stranded DNA virus family Anelloviridae, there is still no convin

105 dae was the second most prevalent eukaryotic DNA virus family.

106 Giant and large eukaryotic double-stranded DNA viruses from the Nucleo-Cytoplasmic Large DNA Virus

107 The assembly of double-stranded DNA viruses, from phages to herpesviruses, is strongly c

108 sma from 1,250 clinically relevant bacteria, DNA viruses, fungi and eukaryotic parasites.

109 on silencing, especially for newly infecting DNA virus genomes entering the nucleus.

110 de editing through assembly methods in large DNA virus genomes raises dual-use concerns, we believe t

111 en complete or near-complete double-stranded DNA virus genomes.

112 n is a key component of many double-stranded DNA viruses, governing capsid assembly and genome packag

113 Herpesviruses are DNA viruses harboring the capacity to establish lifelong

114 acellular PRR-signaling pathways that detect DNA viruses have been characterized, particularly in mye

115 recently, several oncogenic double-stranded DNA viruses have been found to encode circRNAs.

116 Throughout evolution, large DNA viruses have been usurping genes from their hosts to

117 viral episomes remained unaltered.IMPORTANCE DNA viruses have evolved complex strategies to gain cont

118 Intriguingly, RNA and DNA viruses have evolved strategies to hijack cellular W

119 For example, many vertebrate DNA viruses have hijacked cellular genes encoding cytoki

120 actions between the insect immune system and DNA viruses have received less attention, primarily beca

121 hannels (VRACs) increased propagation of the DNA virus HSV-1 but not the RNA virus VSV.

122 ocused on antiviral compounds active against DNA viruses (HSV, VZV, CMV, HBV) and retroviruses (HIV).

123 The DNA virus human cytomegalovirus (HCMV) encodes a viral C

124 ncoded BBK protein and a novel mechanism for DNA virus immune evasion, resulting in increased CD8(+)

125 ation of gene expression reminiscent of most DNA viruses.IMPORTANCE Herpesviruses infect nearly all h

126 ovides the first evidence of an encephalitic DNA virus in its natural host causing increased MMP acti

127 prevented the lethality of infection with a DNA virus in vivo.

128 ertebrate iridescent virus 6 (IIV6), a large DNA virus in which we previously identified the 340R pro

129 contained bacteria, fungi, RNA viruses, and DNA viruses in each patient.

130 ase, is activated by single stranded RNA and DNA viruses in endocytic compartments resulting in endos

131 Torque Teno Viruses (TTVs) are ubiquitous DNA viruses in humans but not found to be causative for

132 ctively enriched for the genomes of circular DNA viruses in over 70 animal samples, ranging from nema

133 DNA viruses in the family Poxviridae encode poxin enzyme

134 It is suitable for sequencing either RNA or DNA viruses in the field during outbreaks or as an inexp

135 or a key host mediator of innate immunity to DNA viruses in the life cycle of a small pathogenic RNA

136 tly no evidence for a functional role of the DNA viruses included into this analysis in CRC developme

137 ls were highly susceptible to infection with DNA viruses including HSV1, a variant of which is being

138 Double-stranded DNA viruses, including bacteriophages and herpesviruses,

139 well-studied inhibitor of a range of RNA and DNA viruses, including influenza A virus (FLUAV) and hep

140 ic effector that restricts enveloped RNA and DNA viruses, including influenza A, Zika, Ebola, Sindbis

141 ice enhances infectivity by multiple RNA and DNA viruses, including orthomyxoviruses (influenza A), p

142 gly conserved in the complex double-stranded DNA viruses, including the herpesviruses and many bacter

143 les have been found to be encoded by several DNA viruses, including the human gammaherpesvirus Kaposi

144 , SINEs can be induced during infection with DNA viruses, including the model murine gammaherpesvirus

145 ism illustrates another novel means by which DNA viruses incorporate host death regulators that are m

146 Together, these results indicate that DNA viruses induce and suppress NF-kappaB responses, and

147 Here we found that infection with DNA viruses induced interaction of the metabolic checkpo

148 Circular single-stranded DNA viruses infect archaea, bacteria, and eukaryotic org

149 a potent antiviral innate immune response in DNA virus-infected cells.

150 The curiosity-driven discovery of giant DNA viruses infecting amoebas has triggered an intense d

151 alpha-helical TM proteins in double-stranded DNA viruses infecting bacteria and archaea reveals large

152 regulates host IFN responses during RNA and DNA virus infection and identify OASL as a negative-feed

153 f known antiviral pathways in the context of DNA virus infection and identify the first Toll pathway

154 radigm of the role of Rb inactivation during DNA virus infection and uncovers the existence of an alt

155 he biology of these SINE ncRNAs, explore how DNA virus infection may lead to their induction, and des

156 advances in the RLR-mediated restriction of DNA virus infection with an emphasis on the RLR ligands

157 n (IFN) response to transfected DNA ligands, DNA virus infection, and lentivirus infection.

158 characteristic histopathological lesions of DNA virus infection, were observed within the hepatopanc

159 n the intrinsic antiviral immune response to DNA virus infection.

160 cated in antiviral cell death signaling upon DNA virus infection.

161 and virus evasion tactics in the context of DNA virus infection.

162 2 have the opposite effect in the context of DNA virus infection.

163 accumulated establishing the role of RLRs in DNA virus infection.

164 melanogaster, primarily during RNA, but not DNA, virus infection.

165 However, the roles of IFITMs in DNA virus infections have not been studied in detail.

166 no known latency mechanism for chronic small DNA virus infections.

167 ar staining was also present in some RNA and DNA virus infections.

168 nate immunity, leading to the persistence of DNA virus infections.Proteins of the TRIM family have re

169 oma-associated herpesvirus (KSHV), a nuclear DNA virus, inhibits mRNA export in a transcript-selectiv

170 athogens, information on how they respond to DNA viruses is limited, and the roles of PYHIN proteins

171 wever, whether NMD is capable of restricting DNA viruses is not known.

172 viral particle stability for double-stranded DNA viruses is the energetically unfavorable state of th

173 ulting in elimination of integrated proviral DNA; virus is not detected in blood, lymphoid tissue, bo

174 , primarily because few Drosophila-infecting DNA virus isolates are available.

175 tions between a recently isolated Drosophila DNA virus (Kallithea virus [KV]) and immune processes kn

176 The DNA virus Kaposi's sarcoma-associated herpesvirus (KSHV)

177 Circoviruses are the smallest DNA viruses known to infect mammalian and avian species.

178 fever virus (ASFV) is among the most complex DNA viruses known.

179 -36 to regulate infection of closely related DNA viruses: KSHV, Epstein-Barr virus (EBV), and herpes

180 l, observational study, we extracted RNA and DNA virus-like particles from fecal samples from 73 pati

181 To this end, several DNA viruses maintain their genomes as extrachromosomal D

182 f baculoviruses, a group of insect-infecting DNA viruses, many of which have been used in biocontrol.

183 pore is a critical step in the lifecycle of DNA viruses, many of which must successfully deposit the

184 nce suggests that some large double-stranded DNA viruses may also endogenize into the genome of the h

185 These putative large DNA viruses may be infected by B. natans virophages.

186 observation that the genomes of other large DNA viruses might bear SLAM family homologs further unde

187 omes make evolution in these double-stranded DNA viruses more efficient than that in smaller RNA viru

188 omics to identify a family of small circular DNA viruses-named Redondoviridae-associated with human d

189 NA viruses from the Nucleo-Cytoplasmic Large DNA Virus (NCLDV) assemblage represent a remarkably dive

190 other viruses of the nucleocytoplasmic large DNA virus (NCLDV) clade.

191 (ASFV) is a complex nucleocytoplasmic large DNA virus (NCLDV) that causes a devastating swine diseas

192 ssembled genomes of Nucleo-Cytoplasmic Large DNA Viruses (NCLDV) from environments around the globe,

193 phylogenetically distinct nucleocytoplasmic DNA viruses (NCLDV).

194 Although the nucleocytoplasmic large DNA viruses (NCLDVs) are one of the largest group of vir

195 Nucleocytoplasmic large DNA viruses (NCLDVs) are ubiquitous in marine environmen

196 Nucleocytoplasmic large DNA viruses (NCLDVs) have recently become of great inter

197 rent knowledge about nucleocytoplasmic large DNA viruses (NCLDVs) is largely derived from viral isola

198 ey on giant viruses (nucleocytoplasmic large DNA viruses; NCLDVs), which are themselves parasites of

199 In this study, we used a recently isolated DNA virus of Drosophila melanogaster, Kallithea virus (K

200 important in immunity to cytosolic bacteria, DNA viruses, or HIV.

201 Some DNA viruses overcome plant defenses by producing a suppr

202 to have a role in the antiviral response to DNA viruses, physiological RNA species recognized by RIG

203 The recombinant baculoviruses produced viral DNA, virus progeny, and some viral proteins earlier duri

204 The capsids of double-stranded DNA viruses protect the viral genome from the harsh extr

205 eviously undefined family of single-stranded DNA viruses, Redondoviridae, in human ororespiratory sit

206 Adenovirus is a nuclear replicating DNA virus reliant on host RNA processing machinery.

207 Most DNA viruses replicate in the nucleus and exit it either

208 Unlike RNA viruses, most DNA viruses replicate their genomes with high-fidelity p

209 ruses, unlike many well-characterized animal DNA viruses, replicate entirely within the cytoplasm of

210 DNA viruses replicating in the nucleus challenge the res

211 cGAS was necessary for the reduced DNA virus replication observed in OASL-deficient cells.

212 t report of a proviral function of IFITMs in DNA virus replication.

213 Immunity against plasmids and DNA viruses requires DNA, but not RNA, cleavage activity

214 egulates cellular transcription and act as a DNA virus restriction factor.

215 w that TRIM29 is induced upon infection with DNA viruses, resulting in degradation of STING, decrease

216 and internalization of this single-stranded DNA virus results in phage RNA production.

217 ages are recently discovered double-stranded DNA virus satellites that prey on giant viruses (nucleoc

218 clic GMP-AMP synthase (cGAS) is an essential DNA virus sensor that triggers type I interferon (IFN) s

219 viral reads, followed by 9 to 17% for CRESS DNA virus sequences.

220 lar, the circular, Rep-encoding ssDNA (CRESS-DNA) viruses show high diversity and abundance in variou

221 During infection with DNA viruses STING is activated downstream of cGAMP synth

222 Interestingly, only 2 of the 8 DNA viruses studied showed a d (N)/d (S) < 0.10, while 4

223 DNA viruses such as herpesviruses have relatively large

224 than in the context of large double-stranded DNA viruses such as herpesviruses.

225 The genomes of DNA viruses such as human cytomegalovirus (HCMV) are dev

226 l2(-/-) mice and OASL-deficient human cells, DNA viruses such as vaccinia, herpes simplex, and adenov

227 latively recent emergence of single-stranded DNA viruses, such as chicken anemia virus (CAV) and porc

228 Recognition of DNA viruses, such as cytomegaloviruses (CMVs), through p

229 Many double-stranded DNA viruses, such as Epstein-Barr virus, can establish p

230 Most vertebrate and plant RNA and small DNA viruses suppress genomic CpG and UpA dinucleotide fr

231 mplex modifications of HSV-1 and other large DNA viruses than previous technologies, facilitating man

232 the most common human pathogens, is a small DNA virus that belongs to the Parvoviridae As a result o

233 dentify host factors for adenovirus (AdV), a DNA virus that can cause severe respiratory illness in i

234 also restricted infection with an enveloped DNA virus that can enter via the plasma membrane, herpes

235 ia virus (CAV) is a single-stranded circular DNA virus that carries 3 genes, the most studied of whic

236 simplex virus-1 (HSV-1) is a double-stranded DNA virus that causes life-long infections.

237 virus (HCMV) is an enveloped double-stranded DNA virus that causes severe disease in newborns and imm

238 galovirus (HCMV) is a large, double-stranded DNA virus that causes significant human disease, particu

239 BK polyomavirus (BKPyV) is a small DNA virus that establishes a life-long persistent infect

240 pesvirus (KSHV) is a human oncogenic nuclear DNA virus that expresses its genes using the host cell t

241 MPORTANCE Human herpesvirus 6B (HHV-6B) is a DNA virus that infects most children within the first fe

242 African swine fever virus, a double-stranded DNA virus that infects pigs, is the only known member of

243 g multiple viral proteins encoded by a human DNA virus that inhibit the cGAS-STING DNA sensing pathwa

244 s sarcoma-associated herpesvirus (KSHV) is a DNA virus that is linked to several human malignancies.

245 n and infected them with gammaHV68, a common DNA virus that is related to human Epstein-Barr virus.

246 HBV is a DNA virus that utilizes a virus-encoded reverse transcri

247 newly discovered icosahedral double-stranded DNA virus that was isolated from an environmental sample

248 Polydnaviruses are large, double-stranded DNA viruses that are beneficial symbionts of parasitoid

249 e a unique group of circular double-stranded DNA viruses that are considered parasites of giant DNA v

250 on of a family of proteins encoded by insect DNA viruses that are homologous to a 12-kDa circulating

251 CrAss-like phages are double-stranded DNA viruses that are prevalent in human gut microbiomes.

252 lomaviruses (PVs) are small, double-stranded DNA viruses that are responsible for cervical, oropharyn

253 Baculoviruses are large double-stranded DNA viruses that are virulent pathogens of certain insec

254 sses, but also as a natural barrier for most DNA viruses that assemble their nucleocapsids in the nuc

255 nother potential target for gene editing are DNA viruses that cause chronic pathogenic diseases that

256 (HSV-1) and HSV-2 are large, double-stranded DNA viruses that cause lifelong persistent infections ch

257 Geminiviruses are DNA viruses that cause severe crop losses in different p

258 Papillomaviruses are small, double-stranded DNA viruses that encode the E2 protein, which controls t

259 s 1 and 2 (HSV-1 and HSV-2) are large-genome DNA viruses that establish a persistent infection in sen

260 PVs) comprise a large family of nonenveloped DNA viruses that include HPV16, among other oncogenic ty

261 Herpesviridae is a vast family of enveloped DNA viruses that includes eight distinct human pathogens

262 Ascoviruses are large, enveloped DNA viruses that induce remarkable changes in cellular a

263 tructures of two filamentous double-stranded DNA viruses that infect archaeal hosts living in nearly

264 heal matrix.IMPORTANCE Ascoviruses are large DNA viruses that infect insects, inducing a cellular pat

265 genic human papillomaviruses (HPV) are small DNA viruses that infect keratinocytes.

266 Poxviruses are unique among DNA viruses that infect mammalian cells, in that their r

267 Nucleocytoplasmic Large DNA Viruses that infect phytoplankton organisms and regu

268 iridae are a family of large double-stranded DNA viruses that infects the cells of the gut in inverte

269 Ascoviruses are insect-specific large DNA viruses that mainly infect noctuid larvae, and are t

270 t and heterogeneous group of double-stranded DNA viruses that preferentially infect the cutaneous and

271 PyVs are DNA viruses that rely upon host replication proteins for

272 RTANCE Poxviruses are large, double-stranded DNA viruses that replicate entirely in the cytoplasm, an

273 Most DNA viruses that use recombination-dependent mechanisms

274 Parvoviruses are single-stranded DNA viruses that use the palindromic structures at the e

275 ribe the structure of faustovirus, the first DNA virus (to our knowledge) that has been found to use

276 Infection of cells with DNA viruses triggers innate immune responses mediated by

277 The small DNA virus TTV was unexpectedly found in all culture-nega

278 a cloned A* gene.IMPORTANCE Double-stranded DNA viruses typically package their genomes into a prefo

279 Double-stranded DNA viruses use ATP-powered molecular motors to package

280 arr virus and possible other double-stranded DNA viruses use TRIM29 to suppress local innate immunity

281 estimated the relative abundances of RNA and DNA viruses using a mass ratio approach and conducted sh

282 The remaining unclassified CRESS DNA virus was related to smacoviruses but possessed a ge

283 hat the genetic diversity of double-stranded DNA viruses was generated over long periods of time, sim

284 viruses and host genomes or between RNA and DNA viruses, was previously thought to be practically no

285 ular Rep-encoding single-stranded DNA (CRESS-DNA) virus, were also detected in nasal swabs, possibly

286 rgence of previously unknown double-stranded DNA viruses which delineate and extend the diversity of

287 Many double-stranded DNA viruses which parasitize such hosts, including the f

288 ecurrent evolution of a virulent strain of a DNA virus, which infects multiple Drosophila species.

289 rdance in exit strategies among some RNA and DNA viruses, which exploit autophagy pathway for their r

290 ruses that are considered parasites of giant DNA viruses, which in turn are known to infect eukaryoti

291 Unlike double-stranded DNA viruses, which pump their genome into a preformed ca

292 The Herpesviridae are structurally complex DNA viruses whose capsids undergo primary envelopment at

293 cytoplasmic innate recognition molecule for DNA viruses whose function is lost in a variety of cance

294 SFV) is a highly pathogenic, double-stranded DNA virus with a marked tropism for cells of the monocyt

295 tive cycle of vaccinia virus (VACV), a large DNA virus with about 200 genes.

296 tially double-stranded, reverse-transcribing DNA virus with proteins encoded by multiple overlapping

297 he Hawaiian strain of ChHV5 may be the first DNA virus with such an unusual life history.

298 available database of 3908 isolate reference DNA viruses with 264 413 computationally identified vira

299 Human polyomaviruses are double-stand DNA viruses with a conserved genomic structure, yet they

300 Hepadnaviruses are hepatotropic enveloped DNA viruses with an icosahedral capsid.