ライフサイエンスコーパス: DO

1 DO (HLA-DO, in human; murine H2-O) is a highly conserved

2 DO donors are underutilized in pediatric liver transplan

3 DO event temperature reconstructions depend on the stabl

4 DO events involved the near-complete disappearance of gl

5 DO fluxes at the SWI calculated from the simulated profi

6 DO has expanded the number and diversity of research com

7 DO induces differential effects on epitope presentation

8 DO is a biomedical resource of standardized common and r

9 DO is moving to a multi-editor model utilizing Protege t

10 DO mouse stock samples nearly the entire genetic reperto

11 %DO overwhelmed the influence of atmospheric CO(2), tempe

12 DO perturbation of 0.25 and 0.5 cycles/h led to most abu

13 DO were far more likely than NDO to report walking for r

14 DO(2), MO(2), and OEF were calculated from these measure

15 entified from whole-genome sequencing of 228 DO mice.

16 n Breast Cancer-Disparities in Outcomes (ABC-DO) prospective cohort study was done at eight hospitals

17 ula: see text]O enrichment during the abrupt DO event onsets.

18 A survey of 191 dog owning adults (DO), 455 non-dog owning adults (NDO), and 46 children, l

19 us work identified DOB variants that altered DO function.

20 ut are expected to increase these pCO(2) and DO cycles in severity and duration of acidification and

21 is indicates that fluctuations in pCO(2) and DO may benefit coastal organisms by providing periodic p

22 G V O(2) was reduced via impaired Q O(2) and DO(2) (P < 0.05 for each).

23 ve and diffusive O(2) transport ( Q O(2) and DO(2) , respectively; Fick Principle and Law of Diffusio

24 commercial red wines from DO Rias Baixas and DO Ribeira Sacra (Spain) by UV-VIS-NIR spectroscopy.

25 ill outline the features of the MDP, CC, and DO mouse models and will discuss published case studies

26 f DO listserv members, twitter followers and DO website usage.

27 MLSS and DO were shown to be effective in shaping functional gene

28 The negative correlations between MRP and DO is marked (r = -0.89).

29 ted to a sequential oxidation by nitrite and DO.

30 h lower P/Fe irrespective of temperature and DO treatments.

31 rom heterotrophy (%DO < 100) to autotrophy (%DO > 100) and dramatic shifts in aragonite saturation st

32 Between 3 and 7 days of BCCAO, DO(2) increased, OEF decreased, and there was no signifi

33 on activation mediated by high affinity BCR, DO tuning is synchronized with antigen internalization a

34 eports have suggested possible links between DO and autoimmunity, Hepatitis C (HCV) infection, and ca

35 show that bubble nucleation is dominated by DO concentration (affected by cellular metabolism), rath

36 text]O in southern Greenland is explained by DO event sea ice changes.

37 ago-Rivera A, Morse G, DeCaprio A, Carpenter DO, and the Akwesasne Task Force on the Environment.

38 ated with intermittent aeration, considering DO limitation, direct pH effects on enzymatic activities

39 s, and non-crystalline U(IV) rapidly consume DO and nitrate to maintain anoxic conditions, yielding F

40 In contrast, DO-PI(4,5)P2 but not DP-PI(4,5)P2 recruited Gag to GUVs,

41 We anticipate that coupling DO sequences with tumor-homing transduction domains can

42 from Xinglong Cave, northern China, covering DO 15 and 14.

43 CRISPR-DO uses a computational sequence model to predict sgRNA

44 tion for the Design and Optimization (CRISPR-DO) of guide sequences that target both coding and non-c

45 We crossed DO mice with syngeneic HER2 transgenic mice to study the

46 lti-editor model utilizing Protege to curate DO in web ontology language.

47 inadequate compensation by oxygen delivery (DO(2)) and extraction fraction (OEF) after BCCAO.

48 of retinal blood flow (F), oxygen delivery (DO(2)), oxygen metabolism (MO(2)), oxygen extraction fra

49 y related to regional variations in density, DO, and other variables (regression and redundancy analy

50 d(-1), was found to more accurately describe DO consumption kinetics.

51 ic sediment-water incubations with different DO and temperature treatments confirmed suspected mechan

52 The genetically diverse DO mice provided a reproducible response to benzene expo

53 issected pH-dependence of spontaneous and DM-DO-mediated class II peptide exchange and identified an

54 te that active, free DM is generated from DM-DO complexes at late endosomal/lysosomal pH due to irrev

55 pH-exposure of DM-DO in cell lysates corroborates such a pH-regulated mech

56 on approaches to determine pH effects on DM-DO function and their mechanistic basis.

57 tonsillar B cells, we found that tunable DM/DO stoichiometry governs DM(free) activity for exchange

58 cal MHCII molecules, HLA-DM (DM) and HLA-DO (DO).

59 ed DO, producing linked feedbacks that drove DO decline and recovery.

60 designed an indirect in-line electrochemical DO removal device (EDOR), utilizing a silver cathode to

61 nger-term reductions after 120 d of elevated DO treatment, relative to an untreated condition predict

62 Although the two genes encoding DO (DOA and DOB) are considered nonpolymorphic, there ar

63 Monarch Initiative among others, and enhance DO's current asserted view and multiple inferred views t

64 ral mechanisms have been proposed to explain DO events, including sea ice, ice shelf buildup, ice she

65 F, DO(2) and MO(2) were 5.2 +/- 3.1 muL/min, 428 +/- 271 nL

66 n of origin (DO) Valdeorras, one of the five DOs in Galicia, wants to promote the production and mark

67 noparticles show a very high sensitivity for DO with a limit of detection (LOD) of 60 nm and can be r

68 ngeneric species of kelp forest fish to four DO levels, ranging from normoxic to hypoxic (8.7, 6.0, 4

69 Although Fro-DO represents a promising ligand in this regard, the bas

70 Instead, Fro-DO's unique reactivity arises from its ability to associ

71 novel electron-deficient olefin ligand, Fro-DO, proved crucial for achieving high rates and chemosel

72 electron-deficient olefin (EDO) ligand, Fro-DO, that promotes the generation of quaternary carbon ce

73 Computational analysis shows that Fro-DO accelerates turnover limiting reductive elimination v

74 evant Ni(II) intermediate indicates that Fro-DO binds to Ni(II) through an additional stabilizing don

75 roduction, and gross primary production from DO changes showed that DO consumption and production did

76 Insulin secretion from DO islets ranged >1,000-fold even though none of the mic

77 Adult liver transplants from DO donors increased from 2% in 2002 to 15% in 2017, whil

78 2017, while pediatric liver transplants from DO donors only increased from <1% to 3% in the same time

79 were determined in commercial red wines from DO Rias Baixas and DO Ribeira Sacra (Spain) by UV-VIS-NI

80 Compared to the sham group, DO(2) and MO(2) were reduced after all BCCAO durations.

81 bound to the liquid phase when PI(4,5)P2 had DO-acyl chains.

82 nt to the seasonal shift from heterotrophy (%DO < 100) to autotrophy (%DO > 100) and dramatic shifts

83 ant to this system; one was abundant in high DO and pH and contained heterotrophs and oxidizers of ir

84 tments, the distribution shifted toward high DO levels, especially in uniform high temperature, confi

85 s strain EF1 from the SUP05 clade under high DO (22 muM), anoxic, and low DO (3.8 muM) concentrations

86 assical MHCII molecules, HLA-DM (DM) and HLA-DO (DO).

87 gulators for peptide loading, HLA-DM and HLA-DO.

88 DO (HLA-DO, in human; murine H2-O) is a highly conserved nonclas

89 expression and a concurrent decrease in HLA-DO in BL cells.

90 nge catalyst, HLA-DM, and its inhibitor, HLA-DO control endosomal generation of peptide/class II majo

91 e previously unappreciated role of H2-O (HLA-DO) in immunity to infections may suggest new approaches

92 ection, and cancer, but the mechanism of how DO contributes to these diseases remains unclear.

93 nt correlations (P = < 0.05) between all HRV(DO) measures to each HRR measure and are presented in ra

94 Within the current study HRV(DO) displayed the strongest correlations to HRR therefor

95 tural variation in the DOA gene also impacts DO function.

96 tion occurring in the human DOA gene impacts DO function and can be linked to specific outcomes of vi

97 lated to climatic variability and changes in DO, and causality testing indicated that these relations

98 Thus, the difference in DO level was attributable to biofilm-induced oxygen dema

99 cid-activated generation of functional DM in DO-expressing cells.

100 sources and demonstrated by a 6.6x growth in DO's user community since 2015.

101 iates explain over 35% of the variability in DO.

102 ineage I gradually decreased with increasing DO until it was washed out.

103 With increasing DO, the rate slowed and the rate-limiting step shifted f

104 Some evidence suggests that pH influences DO regulation of DM function, but pH also affects the st

105 Influent DO was effectively consumed by biogenic iron sulfides in

106 O2 dissolution rate with increasing influent DO concentration and decreasing FeS content.

107 he oxidation of UO2, although FeS still kept DO levels low.

108 This new, to our knowledge, DO F1 platform is a powerful tool for revealing novel im

109 Likewise, DO never fully penetrated the sediment, progressing inwa

110 l that substantial reductions in bulk liquid DO concentrations to 0.5 mg-O(2)/L are possible without

111 lade under high DO (22 muM), anoxic, and low DO (3.8 muM) concentrations.

112 centrations which are most pronounced at low DO concentrations and in regions where the P/Fe ratio in

113 ments confirmed suspected mechanisms: at low DO in water (<4 mg L(-1)), reductive dissolution of ferr

114 esses, there is a need to understand how low DO impacts the kinetics of micropollutant biotransformat

115 onium, whereas the other was abundant in low DO with the capability to reduce nitrate.

116 Static low DO conditions severely decreased embryo survival, larval

117 /L, and ultimately 60% when returning to low DO conditions.

118 5 or greater, while frequent exposure to low DO is already occurring.

119 As we move toward low DO treatment processes, there is a need to understand ho

120 er decadal time scales in aquifers under low DO conditions.

121 This pattern was more pronounced when low DO coincided with high temperature.

122 this period but no measurable loss at lower DO.

123 tion and increased escape time at the lowest DO levels, whereas behavioral metrics for blue rockfish

124 s increased in the following order: C < FO < DO < OP.

125 We exposed male DO mice to benzene (0, 1, 10, or 100 ppm; 75 mice/exposu

126 ited for LOC applications where miniaturized DO removal and/or regulation are desirable.

127 An additional 10-day supply of 0.25 mM DO influent resulted in the release of about 10% and 49%

128 density resulted in decreased dissolved O2 (DO) concentrations (p = 0.0003) measured using real-time

129 n of a verb and its following direct object (DO) noun (e.g., "eat the apple").

130 so showed better agreement with the observed DO fluxes than the simulated profiles with the zero-flux

131 Hemisphere volcanism and Dansgaard-Oeschger (DO) events (>99% confidence), but did not identify a cau

132 abrupt transitions into Dansgaard-Oeschger (DO) events can be studied in detail in Greenland ice cor

133 ory of how and why these Dansgaard-Oeschger (DO) events occur.

134 rming episodes, known as Dansgaard-Oeschger (DO) events.

135 nland ice cores known as Dansgaard-Oeschger (DO) interstadials are linked to changes in tropical circ

136 While 28% of DO donors met splitting criteria, only 3% of those meeti

137 ross-validation results indicate that 58% of DO variability is explained when combining these trends

138 The content of DO has had 192 revisions since 2012, including the addit

139 ults show a 1-2 month lag between the end of DO delivery and rebound to the final near-steady emissio

140 resulting in the characteristic features of DO events.

141 compounds by introducing a negative flux of DO as a lower boundary condition.

142 sediments, usually assume a downward flux of DO from the sediment-water interface (SWI) with a zero-f

143 periodic shifts in the spatial gradients of DO, pH, free ammonia, and free nitrous acid, associated

144 this study was to characterize the impact of DO concentration on pharmaceutical biotransformation rat

145 s that describe the community-wide impact of DO on biotransformation rates.

146 r ability to predict and model the impact of DO on pharmaceutical biotransformations during wastewate

147 luenced the pH, and so the biotic impacts of DO and pH shifts are correlated.

148 t higher temperatures but was independent of DO.

149 disease models by demonstrating that lack of DO increases autoreactivity and susceptibility to autoim

150 text]O paleothermometer to the magnitude of DO event temperature increase: the change in [Formula: s

151 holds the key to understanding the nature of DO events.

152 uests and a steady increase in the number of DO listserv members, twitter followers and DO website us

153 The odds of DO meeting current physical activity guidelines of 150 m

154 , and ammonium) is linked to the presence of DO, which has higher concentrations near the water table

155 ped to explain the concentration profiles of DO, nitrate, and DOC.

156 id products were absent over a wide range of DO values, suggesting that dissolution proceeded through

157 Both pediatric and adult recipients of DO donor livers achieved excellent patient and graft sur

158 ales avoided high temperatures regardless of DO levels.

159 The removal of DO by FeS was significant but incomplete during the inhi

160 The response of DO F1 HER2 transgenic mice was remarkably variable.

161 Increased splitting of DO donor livers could significantly decrease, if not eli

162 Our suite of DO events, simulated using a general circulation model,

163 llected over V1-V4 were measured as; day of (DO) GXT, 3 day (AV3), and 4 day average (AV4).

164 Consequent bubble growth depends not only on DO concentration but also on competition for dissolved g

165 the form of: fried onion (FO), dried onion (DO) and onion peel (OP).

166 r predocumentation (PD), documentation only (DO), or documentation with provider review (PR) cohort b

167 rrent version of the Human Disease Ontology (DO) database expands the utility of the ontology for the

168 Ontology (HPO) terms, 435 Disease Ontology (DO) terms and 228 Disease Ontology Lite (DOLite) terms.

169 ecies model may be used if predicting DOC or DO concentrations is desired.

170 fractional-order (FO) and distributed-order (DO) space-time fractional reaction-diffusion equations.

171 ding modes, which include disorder-to-order (DO) transitions, when proteins fold upon binding, as wel

172 The denomination of origin (DO) Valdeorras, one of the five DOs in Galicia, wants to

173 /revisions, since previously reported in our DO 2015 NAR paper, includes the addition of 2650 new dis

174 ponse was investigated in Diversity Outbred (DO) F1 mice that express human HER2.

175 We sought to evaluate Diversity Outbred (DO) mice as a tool for exposure threshold assessment and

176 d 233,447 islets from 483 Diversity Outbred (DO) mice maintained on a Western-style diet, and measure

177 laborative Cross (CC) and Diversity Outbred (DO) models.

178 t populations such as the Diversity Outbred (DO) mouse stock accumulate large numbers of crossover (C

179 ative Cross (CC) strains, Diversity Outbred (DO) stock, and their isogenic founder strains.

180 ity mouse population, the Diversity Outbred (DO), we found substantial sex and genetic effects on res

181 d to compare trends in use of drug overdose (DO) donors in adult vs. pediatric liver transplants and

182 d systematic variations in dissolved oxygen (DO) and associated variables (nitrite, chlorophyll, and

183 on in situ observations of dissolved oxygen (DO) and mechanistic models based on a representation of

184 is opposite to that of the dissolved oxygen (DO) and nitrate concentrations.

185 r table peaking transports dissolved oxygen (DO) and nitrate from the vadose zone into the alluvial a

186 Changes in dissolved oxygen (DO) and undigested BSA concentration were monitored duri

187 uations of temperature and dissolved oxygen (DO) are substantial.

188 e FeS as a function of pH, dissolved oxygen (DO) concentration, and FeS content.

189 imultaneous measurement of dissolved oxygen (DO) concentration, glucose and lactate concentrations in

190 em, very high and very low dissolved oxygen (DO) concentrations resulted in lower emissions, while in

191 Dissolved oxygen (DO) concentrations shape the biogeochemistry and ecologi

192 d retention time (SRT) and dissolved oxygen (DO) concentrations), two full-scale municipal wastewater

193 Exposure to low dissolved oxygen (DO) conditions may have deleterious effects on early lif

194 fluctuations in pCO(2) and dissolved oxygen (DO) conditions on diel, tidal, seasonal and interannual

195 Low dissolved oxygen (DO) conditions selected for and high aeration inhibited

196 Dissolved oxygen (DO) did not observably inhibit Cr(VI) removal because Fe

197 ed operational bulk liquid dissolved oxygen (DO) from above 2 mg/L to at or below 0.5 mg/L.

198 urements demonstrated that dissolved oxygen (DO) in biofilm-free dermal tissue was 4.45 +/- 1.17 mg/l

199 ffusion and consumption of dissolved oxygen (DO) in sediments, usually assume a downward flux of DO f

200 ic noncrystalline U(IV) by dissolved oxygen (DO) in the presence of mackinawite (FeS).

201 ection of oxygen including dissolved oxygen (DO) is of great interest in various applications.

202 The influent dissolved oxygen (DO) level was increased stepwise to 6.5-8.5 mg/L and 17-

203 related to differences in dissolved oxygen (DO) level, and it was not explained by the spatial dista

204 d, giving rise to elevated dissolved oxygen (DO) levels and remobilization of U(IV).

205 Under dissolved oxygen (DO) levels of 2.5-3.0 mg/L, N2O emission from the nitrit

206 showed that at restricted dissolved oxygen (DO) the numbers of differentially expressed genes (DEGs)

207 for producing gradients of dissolved oxygen (DO) within a lab-on-a-chip platform.

208 On the basis of dissolved oxygen (DO), ammonium, nitrite, and nitrate profiles within the

209 ariability in temperature, dissolved oxygen (DO), and pH increases as pCO(2) increases in the atmosph

210 ored variables were pH and dissolved oxygen (DO), and soft sensors were used to predict nitrification

211 s profoundly influenced by dissolved oxygen (DO), carbonate, and solutes such as Ca(2+).

212 ce World War II, e.g., low dissolved oxygen (DO), decreased water clarity, and harmful algal blooms (

213 Dissolved oxygen (DO), nitrate, and dissolved organic carbon (DOC) were me

214 chloramine, free chlorine, dissolved oxygen (DO), pH, ammonium, nitrite, and nitrate profiles were ac

215 Changes in dissolved oxygen (DO), pH, and other variables were similar across bioreac

216 between N2O flux and NO3-, dissolved oxygen (DO), temperature, land use and surficial geology in the

217 ced water clarity, and low dissolved oxygen (DO), while decreased N loadings from 1981-2012 suggest m

218 to cyclic perturbations of dissolved oxygen (DO).

219 ds to rapid consumption of dissolved oxygen (DO).

220 the presence of nitrite or dissolved oxygen (DO).

221 on pretreatments to remove dissolved oxygen (DO).

222 experience fluctuations in dissolved oxygen (DO).

223 Both unsaturated dioleoyl-PI(4,5)P2 [DO-PI(4,5)P2] and saturated dipalmitoyl-PI(4,5)P2 [DP-PI

224 ting concentration gradient supports passive DO diffusion from the sample stream into the deoxygenati

225 allele-independent relationship between pH, DO/DM ratio and efficient peptide exchange.

226 Current strategies for portable DO removal offer limited practicality, because of their

227 ted no significant differences in predicting DO and DOC concentrations.

228 osomal pH due to irreversible, acid-promoted DO destruction rather than DO/DM molecular dissociation.

229 (EDOR), utilizing a silver cathode to reduce DO in a chamber that is fluidically isolated from the sa

230 ly, several of the variants produced reduced DO protein levels yet efficiently inhibited DM activity.

231 perties and processes collectively regulated DO, producing linked feedbacks that drove DO decline and

232 id glacial climate shifts closely resembling DO events.

233 Higher rARU expression at restricted DO was associated with up-regulation of 24 heat shock ch

234 At restricted DO, rARU mRNA was 5-fold higher and the protein expressi

235 ine candidate in E. coli by using restricted DO growth.

236 Dissolved oxygen saturation (%DO) decreased by -0.24 +/- 0.036% yr(-1), with site-spec

237 FeS effectively scavenged DO and preferentially reacted with oxygen, contributing

238 micro-chamber containing all three sensors (DO, glucose, and lactate) was made to evaluate metabolic

239 Batch experiments were performed at several DO concentrations using biomass from a full-scale wastew

240 Using high-resolution, in situ DO time-series collected over the course of a year in a

241 Linear and stable DO gradients with high spatial resolution are establishe

242 me geostatistical framework for synthesizing DO observations with hydrodynamic-biogeochemical model s

243 during co-culture with naive transgenic TCR DO.11.10 T cells in vitro and reduced their ability, fol

244 ted that such peptides, which we have termed DO peptides, are involved in disulfide-dithiol exchange

245 nsity genotype data from [Formula: see text] DO mice, and localized 2.2 million CO events to interval

246 le, acid-promoted DO destruction rather than DO/DM molecular dissociation.

247 tion, and whole-body imaging, we report that DO affects the repertoire of presented self-peptides by

248 system (Jellyfish Lake, Palau), we show that DO declined throughout the marine lake and subsequently

249 ed redundancy analysis was used to show that DO perturbations correlate with the abundance of Pseudom

250 imary production from DO changes showed that DO consumption and production did not accelerate nor col

251 ransferases as candidate genes suggests that DO mice may provide additional insight into benzene-indu

252 The DO cohort showed no significant differences in the risk

253 The DO disease classification includes specific formal seman

254 The DO levels are correlated with eutrophication that possib

255 The DO levels in the sample stream were determined by cyclic

256 The DO mice display interindividual variation in toxicity re

257 The DO's continual integration of human disease knowledge, e

258 Nitritation was sustained even after the DO was lowered subsequently.

259 h of the DO's knowledgebase has expanded the DO's utility for exploring the multi-etiology of human d

260 low automation highlight the updates for the DO since 2015.

261 rder 10 kb) patterns of recombination in the DO, we overlaid putative recombination hotspots onto our

262 Results show removal of 98% of the DO in a test sample at flow rates approaching 50 muL/min

263 g context-independent semantic models of the DO noun with contextually constrained noun models reflec

264 underpinning the verb's modification of the DO noun's activated semantics.

265 he resulting sex-averaged genetic map of the DO population is highly concordant with large-scale (ord

266 onal parameter affecting the accuracy of the DO soft sensor.

267 The enhanced breadth and depth of the DO's knowledgebase has expanded the DO's utility for exp

268 Since the DO 2012 NAR paper, there have been hundreds of term requ

269 Even when the DO level was reduced to 0.3-0.8 mg/L, N2O emission from

270 % when the DO was 6.5-8.5 mg/L, 90% when the DO was 17-20 mg/L, and ultimately 60% when returning to

271 e emission was reduced by about 70% when the DO was 6.5-8.5 mg/L, 90% when the DO was 17-20 mg/L, and

272 the microbial community 16S rRNA pool due to DO concentration.

273 nts in two lakes, kinetic models were fit to DO microprofiles using zero-order and first-order kineti

274 es of AOB and NOB microcolonies responded to DO levels in accordance with their oxygen affinities.

275 h the groundwater community and responded to DO.

276 raninite loss rates were highly sensitive to DO, with near-complete loss at >0.6 mg/L over this perio

277 did a household-randomised, unblinded trial (DO ART) of delivery of ART in the community compared wit

278 d energy generating pathways at unrestricted DO were associated with lower rARU expression.

279 down-regulated as compared with unrestricted DO.

280 on 27-fold higher compared with unrestricted DO.

281 We used DO mice treated with morphine to map quantitative trait

282 Using DO QTL analysis, we show that MHC-IB reactive NK cells e

283 Using DO quantitative trait locus (QTL) analysis, we mapped th

284 ncentration limit of 0.205 ppm benzene using DO mice.

285 Studies using DO mice can localize genetic associations with high prec

286 Focusing on the verb-DO noun relationship in simple spoken sentences, we appl

287 imary product (formation within seconds when DO absent, no intermediates detected) and (ii) as a tran

288 DM catalyzes peptide loading, whereas DO, an MHCII substrate mimic, prevents DM from interacti

289 , TS (r = -0.83), and BOD (r = -0.81), while DO exhibited highest negative correlation.

290 enic iron sulfides in the BRS+ column, while DO and a large U spike were detected after only a brief

291 mal tissue was 4.45 +/- 1.17 mg/liter, while DO levels for biofilm-infected tissue declined sharply f

292 tems; as a result, understanding how and why DO varies in space and time is of fundamental importance

293 d dissolution of UO2 was observed along with DO breakthrough in the reactor.

294 Any soluble DM that remains in complex with DO stays inert.

295 mation, and correlated this information with DO-RIP-Seq-identified DND1 direct targets.

296 it Cr(VI) removal because Fe(II) reacts with DO more slowly than it does with Cr(VI), and Cr(VI) remo

297 per Kelvin temperature increase reduces with DO event amplitude.

298 ss the impact of static and cycling pCO(2) x DO conditions of various magnitudes and frequencies on e

299 marine organisms respond to natural pCO(2) x DO variability and future climate change remains largely

300 Cycling pCO(2) x DO, however, reduced these negative effects of static co

301 [Table: see text] WHAT WOULD YOU DO NEXT?