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1                                              E. chaffeensis binding to and subsequent infection of mo
2                                              E. chaffeensis BolA bound to the promoters of genes enco
3                                              E. chaffeensis bolA complemented a stress-sensitive E. c
4                                              E. chaffeensis cannot synthesize phosphatidylcholine or
5                                              E. chaffeensis CtrA bound to the promoters of late-stage
6                                              E. chaffeensis experiences temperature changes during tr
7                                              E. chaffeensis expresses a sensor kinase, PleC, and a co
8                                              E. chaffeensis has a multigene family of major outer mem
9                                              E. chaffeensis inclusions were labeled with the transfer
10                                              E. chaffeensis induced rapid tyrosine phosphorylation of
11                                              E. chaffeensis infection activated the phosphatidylinosi
12                                              E. chaffeensis infection did not result in dramatic chan
13                                              E. chaffeensis infection in a human monocyte cell line (
14                                              E. chaffeensis strains induce strikingly variable inflam
15                                              E. chaffeensis TRP75 and E. canis TRP95 were immunopreci
16                                              E. chaffeensis was sensitive to closantel, an HK inhibit
17                                              E. chaffeensis, therefore, can recruit interacting signa
18                                              E. chaffeensis-EHRL-4-TRIM21 complexes caused significan
19                                              E. chaffeensis-specific cytotoxic T cells were not detec
20 responses to E. chaffeensis lipoproteins, 13 E. chaffeensis lipoprotein genes were cloned into a mamm
21                                       All 16 E. chaffeensis IFA-positive sera reacted with rP30.
22  to analyze the antibody responses of the 37 E. chaffeensis indirect fluorescent-antibody assay (IFA)
23                      Nearly the entire (99%) E. chaffeensis P120 gene (1,616 bp), the 14-repeat regio
24 129S6-Cd4(tm1Knw) mice also developed active E. chaffeensis-specific immunoglobulin G responses that
25                                   Additional E. chaffeensis surface proteins detected were OMP85, hyp
26  the white-tailed deer agent, and additional E. chaffeensis-positive samples).
27 ption of the uridine-cytidine kinase affects E. chaffeensis replication in human macrophages.
28                                        After E. chaffeensis infection, canonical and noncanonical Wnt
29    The addition of oxytetracycline 6 h after E. chaffeensis infection caused a decrease in TfR mRNA w
30 f Amblyomma americanum ticks before or after E. chaffeensis transmission to naive dogs.
31 r rise without detectable antibodies against E. chaffeensis.
32 the hypothesis that immune responses against E. chaffeensis would be different if the mice are challe
33            In the absence of MHC-II alleles, E. chaffeensis infections persisted throughout the entir
34                                     Although E. chaffeensis induces the generation of several cytokin
35                                     Although E. chaffeensis lacks entire lipopolysaccharide and most
36 ss spectrometry identified the protein as an E. chaffeensis 12.3-kDa hypothetical protein, which was
37 ted strongly with antibodies in sera from an E. chaffeensis-infected dog and human monocytotropic ehr
38 rophoretic mobility shift assays revealed an E. chaffeensis-encoded protein that specifically bound t
39 ast two-hybrid analysis demonstrated that an E. chaffeensis type 1 secretion system substrate, TRP32,
40       E. ewingii accounted for 20 (91%), and E. chaffeensis accounted for 1 (5%) of the positives.
41                           Some HGE agent and E. chaffeensis inclusions colocalized with major histoco
42 graphic regions where both the HGE agent and E. chaffeensis occur.
43                          Ehrlichia canis and E. chaffeensis are tick-borne obligatory intramonocytic
44  a 28- and a 27-kb locus in the E. canis and E. chaffeensis genomes, respectively.
45        Western blot analysis of E. canis and E. chaffeensis lysates with the anti-rMmpA serum resulte
46 ter membrane proteins (OMPs) of E. canis and E. chaffeensis.
47                            E. canis gp36 and E. chaffeensis gp47 were differentially expressed only o
48  peptide repeat units from E. canis gp36 and E. chaffeensis gp47 were substantially less immunoreacti
49 A. phagocytophilum and one of B. microti and E. chaffeensis, which were confirmed by the LDTs.
50  peptides are conserved between E. muris and E. chaffeensis OMP-19, and they elicited IFN-gamma produ
51 B4, and virB6) of both A. phagocytophila and E. chaffeensis were arranged downstream from a sodB gene
52 ese five genes in both A. phagocytophila and E. chaffeensis were polycistronically transcribed and co
53 d endocytosis directs A. phagocytophilum and E. chaffeensis to an intracellular compartment secluded
54 cal sensitivities for A. phagocytophilum and E. chaffeensis were 93% and 84%, respectively, and speci
55 rkansas genomic library by probing with anti-E. chaffeensis hyperimmune mouse ascitic fluid.
56 n around HGE agent inclusions but not around E. chaffeensis inclusions.
57 his macrophage-tropic bacterium, we assessed E. chaffeensis infections in three mouse strains with di
58     Recently, molecular interactions between E. chaffeensis 47-kDa tandem repeat (TR) protein (TRP47)
59 sferrin receptors (TfRs) accumulated on both E. chaffeensis and E. sennetsu, but not HGE agent, inclu
60 retic mobility shift assays showed that both E. chaffeensis and E. sennetsu infection increased the b
61 which peaked at 24 h postinfection with both E. chaffeensis and E. sennetsu infection in THP-1 or HL-
62                          Infection with both E. chaffeensis and E. sennetsu, but not HGE agent, in th
63            The cytokine-inducing activity by E. chaffeensis PBP provides novel insights into pathogen
64 y indistinguishable from infection caused by E. chaffeensis or the agent of human granulocytic ehrlic
65 protein-processing enzymes were expressed by E. chaffeensis cultured in the human promyelocytic leuke
66 sate, suggesting that it is not expressed by E. chaffeensis cultured in THP-1 cells.
67 r VirB6 proteins and VirB9 were expressed by E. chaffeensis in THP-1 cells, and amounts of these five
68           Multiple lipoproteins expressed by E. chaffeensis in vitro and in vivo may play key roles i
69 e host cell-specific antigenic expression by E. chaffeensis.
70 n of both the IL-8 promoter and NF-kappaB by E. chaffeensis.
71 t canonical and noncanonical Wnt pathways by E. chaffeensis TRP effectors stimulates phagocytosis and
72                         Expression of PBP by E. chaffeensis was upregulated during its intracellular
73 n of host cytokine and chemokine profiles by E. chaffeensis strains underlies the distinct host liver
74 nslocation of bacterially encoded protein by E. chaffeensis and to identify a specific binding motif
75 e the mechanism of TfR mRNA up-regulation by E. chaffeensis and E. sennetsu infection.
76          Only one paralog was transcribed by E. chaffeensis in three developmental stages of Amblyomm
77  Anaplasma phagocytophilum, Ehrlichia canis, E. chaffeensis, E. ewingii, Rickettsia rickettsii, R. co
78  6 of 52 (11.5%) from Rhode Island contained E. chaffeensis DNA.
79 m mutagenesis is a valuable tool in defining E. chaffeensis genes critical for its persistent growth
80  in mice infected with the tick cell-derived E. chaffeensis compared to DH82-grown bacteria.
81 teins from macrophage- and tick cell-derived E. chaffeensis, respectively.
82  and Rhode Island for PCR analysis to detect E. chaffeensis DNA.
83 CL11, which were strongly upregulated during E. chaffeensis infection and were also upregulated by di
84              Among the 38 patients enrolled, E. chaffeensis was isolated from the blood of 7 (18%) an
85                           E. coli expressing E. chaffeensis SurE exhibited increased resistance to os
86                                       First, E. chaffeensis avoided stimulation of or repressed the t
87 ntibodies reactive to E. chaffeensis and for E. chaffeensis-specific 16S rRNA gene fragments by an in
88 ompared with previously described assays for E. chaffeensis.
89 rates that both PCR and culture of blood for E. chaffeensis have high diagnostic yields.
90 rs of tandem repeats, were characterized for E. chaffeensis from white-tailed deer (Odocoileus virgin
91  permissive and nonpermissive conditions for E. chaffeensis growth.
92  nucleotide salvage pathway is essential for E. chaffeensis replication and that it may be important
93  that D. melanogaster is a suitable host for E. chaffeensis.
94 e obtained for HL-60 cells used as hosts for E. chaffeensis and A. phagocytophilum.
95 otide variation than previously reported for E. chaffeensis from infected humans or ticks.
96 e tested whether cholesterol is required for E. chaffeensis and A. phagocytophilum.
97 ge PCR assay, but not by assays specific for E. chaffeensis or the agent of human granulocytic ehrlic
98 sis-containing vacuoles than in vacuole-free E. chaffeensis.
99 feensis-containing vacuoles and vacuole-free E. chaffeensis.
100  not amplify the 200-bp target amplicon from E. chaffeensis, the human granulocytic ehrlichiosis agen
101 esota or Wisconsin were found not to be from E. chaffeensis or E. ewingii and instead to be caused by
102 produce PCR products with DNA extracted from E. chaffeensis-, E. canis-, or E. phagocytophila-infecte
103 era from E. canis-infected dogs but not from E. chaffeensis-infected patients.
104                          Removal of PBP from E. chaffeensis lysate using penicillin affinity column a
105 e actively transcribed in cell-culture grown E. chaffeensis.
106                             Macrophage-grown E. chaffeensis was cleared in 2 weeks from the peritoneu
107 cores, identity of the primers to homologous E. chaffeensis sequences, and the availability of simila
108 med if the ELISA is positive), we identified E. chaffeensis or a serologically and antigenically simi
109                                           In E. chaffeensis we predicted three pairs of putative two-
110 (MSP-2) in A. marginale and HGE and OMP-1 in E. chaffeensis.
111 the N-terminal TR region (18 amino acids) in E. chaffeensis and the complete TR (24 amino acids) in E
112 own to be surface exposed), were detected in E. chaffeensis cultured in human monocytic leukemia THP-
113             The P43 gene was not detected in E. chaffeensis DNA by Southern blot, and antisera agains
114 e sequence polymorphisms in several genes in E. chaffeensis strains have been reported, global genomi
115 ng the protein expression and interaction in E. chaffeensis.
116 y that documents that insertion mutations in E. chaffeensis that cause attenuated growth confer prote
117                        Targeted mutations in E. chaffeensis were created to disrupt two genes, and al
118 idic C terminus of E. canis TRP95 but not in E. chaffeensis TRP75.
119 ssion of penicillin-binding protein (PBP) in E. chaffeensis was analyzed by reverse-transcription pol
120 cted, which was strikingly more prevalent in E. chaffeensis-containing vacuoles than in vacuole-free
121 variable-length PCR target (VLPT) protein in E. chaffeensis.
122             Major immunoreactive proteins in E. chaffeensis (75-kDa) and E. canis (95-kD) whole-cell
123 age-specific expression of the T4S system in E. chaffeensis.
124 is the first to examine genetic variation in E. chaffeensis from a nonhuman vertebrate host.
125  inhibitor, globomycin, was found to inhibit E. chaffeensis infection and lipoprotein processing in H
126 strate that huMAbs are capable of inhibiting E. chaffeensis infection by distinct effector mechanisms
127 -butyldimethysilyl)-c-di-GMP (CDGA) inhibits E. chaffeensis internalization into host cells by facili
128 egulate nutrient uptake during intracellular E. chaffeensis development at both temperatures.
129 these five proteins were similar in isolated E. chaffeensis-containing vacuoles and vacuole-free E. c
130            Here we demonstrate that isolated E. chaffeensis outer membranes have porin activities, as
131                                   The 28-kDa E. chaffeensis and 30-kDa E. canis native proteins were
132 eral cytokines and chemokines by leukocytes, E. chaffeensis lacks lipopolysaccharide and peptidoglyca
133                        The discovery of many E. chaffeensis proteins crucial for its continuous in vi
134                                         More E. chaffeensis-infected monocytes transmigrated than uni
135         The current study identified a novel E. chaffeensis ubiquitin ligase and revealed an importan
136                                  Addition of E. chaffeensis resulted in rapid increases in the level
137                                  Analysis of E. chaffeensis and A. phagocytophilum genome sequences r
138                     Western blot analysis of E. chaffeensis membrane and soluble fractions using anti
139 first and the most comprehensive analysis of E. chaffeensis-expressed proteins.
140 s critical for conferring rapid clearance of E. chaffeensis.
141 detected, and EHRL-4-mediated degradation of E. chaffeensis was abrogated by the autophagy inhibitor
142 h PCR target, is useful for PCR detection of E. chaffeensis and differentiation of isolates.
143 e to that of the nested PCR for detection of E. chaffeensis in infected DH82 cells, experimentally in
144 more sensitive than the PCR for detection of E. chaffeensis regardless of the nature of the specimens
145 Thus, this RT-PCR is useful for detection of E. chaffeensis when a high sensitivity is required.
146      During the intracellular development of E. chaffeensis, both P28 and OMP-1F were expressed mostl
147                                 Diagnosis of E. chaffeensis infection by indirect immunofluorescence
148              A type IV secretion effector of E. chaffeensis blocks mitochondrion-mediated host cell a
149 f the members of the p28 multigene family of E. chaffeensis, sera from two beagle dogs experimentally
150 tion methods to investigate the functions of E. chaffeensis genes.
151                  The 120-kDa protein gene of E. chaffeensis contains four identical 240-bp tandem rep
152 30-kDa major outer membrane protein genes of E. chaffeensis and E. canis, respectively.
153 ated in a 23kb DNA fragment in the genome of E. chaffeensis.
154 These data suggest that the rMAP2 homolog of E. chaffeensis may have potential as a test antigen for
155                        The identification of E. chaffeensis surface-exposed proteins provides novel i
156          Recently, molecular interactions of E. chaffeensis tandem repeat proteins 47 and 120 (TRP47
157    The P28s were divergent among isolates of E. chaffeensis also.
158 c diversity of the P28 among the isolates of E. chaffeensis suggest that P28s may be involved in immu
159 nced and compared in 12 clinical isolates of E. chaffeensis to determine allele variation.
160 res infected with nine different isolates of E. chaffeensis, blood samples from seven patients with m
161             When the three human isolates of E. chaffeensis, each belonging to a different genogroup,
162 ence of p28 among all five human isolates of E. chaffeensis.
163                   More frequent isolation of E. chaffeensis from patients with infection should furth
164 d in this study suggest that the membrane of E. chaffeensis is very complex, having many expressed pr
165 munofluorescent microscopy in the nucleus of E. chaffeensis-infected host cells and was detected in n
166 f E. canis and the corresponding ortholog of E. chaffeensis (47 kDa) were identified and the proteins
167 p30 of Ehrlichia canis (< or =71.3%), p28 of E. chaffeensis (< or =68.3%), and map1 of Cowdria rumina
168  protein with < or =69.1% identity to P28 of E. chaffeensis, < or =67.3% identity to P30 of E. canis,
169 n or closely related interacting partners of E. chaffeensis TRP32, TRP47, and TRP120 demonstrate a mo
170 iated molecular patterns and pathogenesis of E. chaffeensis infection.
171 d chromatography purified, and native PBP of E. chaffeensis were investigated for their ability to in
172  were observed primarily in the periplasm of E. chaffeensis and E. canis.
173 ts revealed distinct virulence phenotypes of E. chaffeensis strains with defined genome sequences.
174                     Although pretreatment of E. chaffeensis with CDGA did not reduce bacterial bindin
175                   Entry and proliferation of E. chaffeensis in THP-1 cells were significantly blocked
176 sponses to another outer membrane protein of E. chaffeensis (GP120) showed similar temporal and quant
177  recognizing four outer membrane proteins of E. chaffeensis (Arkansas strain) including the 25-, 26-,
178  34 sera reacted with any native proteins of E. chaffeensis ranging from 44 to 110 kDa, and 30 sera r
179       To investigate the surface proteins of E. chaffeensis, membrane-impermeable, cleavable Sulfo-NH
180 otal, membrane, and immunogenic proteomes of E. chaffeensis originating from macrophage and tick cell
181 cluding the two-repeat polypeptide region of E. chaffeensis P120.
182 ci was downregulated prior to the release of E. chaffeensis from host THP-1 cells and was upregulated
183 ral responses and the in vivo replication of E. chaffeensis suggests that D. melanogaster is a suitab
184 negative for antibodies against the rMAP2 of E. chaffeensis by using the ELISA.
185    This is the first demonstration of RNA of E. chaffeensis in infected blood and acquisition-fed mal
186 aling regulates aggregation and sessility of E. chaffeensis within the inclusion through stabilizatio
187 t immunization with the p28 of one strain of E. chaffeensis would confer cross-protection against oth
188 tigenic variants of p28 among the strains of E. chaffeensis and the presence of multiple copies of he
189 o compare the genome sequences of strains of E. chaffeensis and to examine the virulence potentials o
190 ikingly different among the three strains of E. chaffeensis: gamma interferon, CCL5, CXCL1, CXCL2, CX
191          This is the most extensive study of E. chaffeensis VLPT and 120-kDa antigen gene genetic var
192 protease HtrA was detected on the surface of E. chaffeensis, and TRP120 was degraded by treatment of
193 d macrophage activation and the synthesis of E. chaffeensis-specific Th1-type immunoglobulin G respon
194 e E. canis p120 is 30% homologous to that of E. chaffeensis p120.
195               Differential transmigration of E. chaffeensis- and A. phagocytophilum-infected leukocyt
196  in southern New England and transmission of E. chaffeensis may occur there.
197                            Heat treatment of E. chaffeensis or the addition of monodansylcadaverine,
198 sis, and TRP120 was degraded by treatment of E. chaffeensis with recombinant E. chaffeensis HtrA.
199 has been implicated as the primary vector of E. chaffeensis.
200 and the variable-length PCR target (VLPT) of E. chaffeensis.
201 lecule inhibitor had a significant impact on E. chaffeensis replication and recruitment of the TRP120
202 tigated the effects of c-di-GMP signaling on E. chaffeensis infection of the human monocytic cell lin
203 nt is unique because it is thus far the only E. chaffeensis recombinant antigen that has been shown t
204 5.8%) goats were positive by diagnostic PCR; E. chaffeensis was isolated in cell culture from one goa
205  To survive and replicate within phagocytes, E. chaffeensis exploits the host cell by modulating a nu
206 his study, we assessed two clonally purified E. chaffeensis mutants with insertions within the genes
207      Genomic DNA was extracted from purified E. chaffeensis strains Wakulla and Liberty, and comparat
208        Western immunoblotting using purified E. chaffeensis and the HGE agent as antigens suggested t
209                                  Recombinant E. chaffeensis PleD showed diguanylate cyclase activity
210 odies in patients' sera with the recombinant E. chaffeensis 120- and 28-kDa proteins as well as the 1
211  by protein immunoblotting using recombinant E. chaffeensis proteins expressed in Escherichia coli.
212 treatment of E. chaffeensis with recombinant E. chaffeensis HtrA.
213 ell knockouts, when challenged with a second E. chaffeensis infection.
214                                      Second, E. chaffeensis up-regulated NF-kappaB and apoptosis inhi
215                [(32)P]c-di-GMP bound several E. chaffeensis native proteins and two E. chaffeensis re
216 n particular, despite its small genome size, E. chaffeensis has four tandem virB6 paralogs (virB6-1,
217              We previously demonstrated that E. chaffeensis is capable of growing in Drosophila S2 ce
218 isiae) two-hybrid analysis demonstrated that E. chaffeensis-secreted tandem repeat protein 120 (TRP12
219             Recently we have determined that E. chaffeensis tandem repeat proteins (TRPs) are type 1
220                           We found here that E. chaffeensis is dependent on host glycerolipid biosynt
221     Therefore, we tested the hypothesis that E. chaffeensis can infect adult Drosophila melanogaster.
222                       The data indicate that E. chaffeensis is exposed to the extracellular milieu du
223                    We recently reported that E. chaffeensis grown in tick cells expresses different p
224                    We recently reported that E. chaffeensis utilizes a type 1 secretion (T1S) system
225             These novel findings reveal that E. chaffeensis exploits canonical and noncanonical Wnt p
226           Analyses of human sera showed that E. chaffeensis-infected patients also generated serologi
227                     Our results suggest that E. chaffeensis CtrA plays a role in co-ordinating develo
228                     Our results suggest that E. chaffeensis invasion is regulated by c-di-GMP signali
229                     The results suggest that E. chaffeensis VirB9, the quadruple VirB6 proteins, and
230                                          The E. chaffeensis strain Wakulla induces diffuse hepatitis
231                                          The E. chaffeensis strains could be divided into three genet
232                                          The E. chaffeensis T1S effector TRP120 is conjugated to SUMO
233                                          The E. chaffeensis-specific immunoglobulin G response was co
234                              We assessed the E. chaffeensis clearance from the peritoneum, spleen, an
235  trafficked to autophagosomes induced by the E. chaffeensis type IV secretion system effector Etf-1,
236 e (1,620 bp), and a 2-repeat region from the E. chaffeensis P120 gene (520 bp) were expressed in Esch
237  the same chromosomal location; however, the E. chaffeensis VLPT gene (594 bp) has tandem repeats tha
238 ovel tandem repeat DNA-binding domain in the E. chaffeensis 120-kDa tandem repeat protein (TRP120) th
239 gene deletion and insertion mutations in the E. chaffeensis genome.
240 ed proteins provides novel insights into the E. chaffeensis surface and lays the foundation for ratio
241                                     Like the E. chaffeensis p120, the E. canis p120 contains tandem r
242 ve genes and that antigenic variation of the E. chaffeensis 28-kDa proteins may result from different
243                     In all, 278 genes of the E. chaffeensis genome were verified as functional genes.
244                 Bioinfomatic analysis of the E. chaffeensis genome, however, predicted genes encoding
245 rly one-fourth of all predicted genes of the E. chaffeensis genome, validating that they are function
246 ential in preventing lysosomal fusion of the E. chaffeensis inclusion compartment.
247 el treatment induced lysosomal fusion of the E. chaffeensis inclusion in a human monocytic leukemia c
248 array of 147,027 chromosome positions of the E. chaffeensis strain Arkansas genome.
249             Carbohydrate was detected on the E. chaffeensis and E. canis recombinant proteins, includ
250           Both protective Abs recognized the E. chaffeensis major outer membrane protein (OMP)-1g.
251        In this study, we determined that the E. chaffeensis effector TRP120 is posttranslationally mo
252              These results indicate that the E. chaffeensis Wakulla strain can induce inflammatory re
253 st one serum sample that also reacted to the E. chaffeensis antigen.
254 ween TRP32 and host targets localized to the E. chaffeensis morulae or in the host cell cytoplasm adj
255                                     When the E. chaffeensis strains were inoculated into severe combi
256 tly different between mice infected with the E. chaffeensis originating from tick cells or macrophage
257                                       Third, E. chaffeensis also inhibited the gene transcription of
258                                        Thus, E. chaffeensis is present in ticks in southern New Engla
259 owed a very high prevalence of antibodies to E. chaffeensis (97 of 112; 87%) and a low prevalence of
260 thought to have cross-reacting antibodies to E. chaffeensis.
261 s developed diagnostic titers of antibody to E. chaffeensis.
262 probable human monocytic ehrlichiosis due to E. chaffeensis also had antibodies to the HGE agent in a
263 that residents of Connecticut are exposed to E. chaffeensis, A. americanum ticks were collected in Co
264 uman leukemia cell line THP-1 was exposed to E. chaffeensis, significant upregulation of IL-8, IL-1be
265  38 (73.7%) goats had antibodies reactive to E. chaffeensis (>/=1:128), and 6 of 38 (15.8%) goats wer
266 icity were tested for antibodies reactive to E. chaffeensis and for E. chaffeensis-specific 16S rRNA
267 hia muris strain that are closely related to E. chaffeensis in C57BL/6 mice.
268 5, an ehrlichial organism closely related to E. chaffeensis isolated from Ixodes ovatus ticks in Japa
269 rlichia muris, a pathogen closely related to E. chaffeensis, resulted in anemia, thrombocytopenia, an
270  and T-cell function on murine resistance to E. chaffeensis.
271 s, are critical for conferring resistance to E. chaffeensis.
272 These data suggest that the host response to E. chaffeensis depends on the source of the bacteria and
273 lecular basis of the host immune response to E. chaffeensis.
274 tein expression and host immune responses to E. chaffeensis lipoproteins, 13 E. chaffeensis lipoprote
275 veral E. chaffeensis native proteins and two E. chaffeensis recombinant I-site proteins, and this bin
276 Ech_0379 mutant and challenge with wild-type E. chaffeensis 1 month following inoculation with the mu
277 ere tested by immunofluorescence (IFA) using E. chaffeensis antigen and by protein immunoblotting usi
278 ay for immunoglobulin M (IgM) and IgG, using E. chaffeensis antigen, identified 44 and 33% of the iso
279       The heat-sensitive component of viable E. chaffeensis cells was essential for these signaling e
280                             To study in vivo E. chaffeensis lipoprotein expression and host immune re
281 t could mediate bacterial clearance in vivo, E. chaffeensis-specific mAbs were generated and administ
282                                         When E. chaffeensis matures into an infectious form, morulae
283  genes suggest a possible mechanism by which E. chaffeensis might evade the host immune defenses.
284 h lysosomes or Golgi-derived vesicles, while E. chaffeensis resides in an early endosomal compartment
285 oxyl-terminal amino acid homology (59%) with E. chaffeensis VLPT and the same chromosomal location; h
286  strongly with TRP120 in HeLa cells and with E. chaffeensis dense-cored morulae and areas adjacent to
287 morular fibrillar structures associated with E. chaffeensis.
288 ; 1 patient had evidence of coinfection with E. chaffeensis and a spotted fever group rickettsia.
289 t inclusions but was weakly colocalized with E. chaffeensis inclusions.
290 a pattern different from that of humans with E. chaffeensis infection but similar to that of a dog ex
291 two beagle dogs experimentally infected with E. chaffeensis were evaluated for the presence of specif
292  naive dogs, or when dogs were infected with E. chaffeensis, the animals developed delayed-type hyper
293 cteria and that of macrophages infected with E. chaffeensis, we have identified few genes that are co
294 y are naturally exposed to and infected with E. chaffeensis.
295  three sera that were IFA positive only with E. chaffeensis, and three sera that were IFA positive on
296 st recombinant P43 (rP43) did not react with E. chaffeensis as detected by indirect fluorescent antib
297 cence contained antibodies that reacted with E. chaffeensis and E. canis antigens in a pattern differ
298 gainst the recombinant proteins reacted with E. chaffeensis P120 and E. canis P140, respectively.
299 nstrated to contain antibodies reactive with E. chaffeensis by indirect immunofluorescence assays (IF
300                     Antibodies reactive with E. chaffeensis were detected in 14 (67%) of the 21 PCR-p

 
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