ライフサイエンスコーパス: EF hand motif

1 7 contains multiple Ca2+ binding sites (i.e. EF-hand motifs).

2 ependent manner by the addition of the first EF hand motif.

3 immediately after the proposed Ca2+ -binding EF hand motif.

4 if packed against a canonical Ca(2+)-binding EF-hand motif.

5 n of a putative intracellular Ca(2+)-binding EF-hand motif.

6 initiation of metal ion binding at the first EF-hand motif.

7 metal-binding domain, RUBCa, that spans the EF-hand motif.

8 eins containing the predicted Ca(2+)-binding EF-hand motif.

9 ity, we focused here on amino acid 12 of the EF-hand motif.

10 inding sites with sequence similarity to the EF-hand motif.

11 kinase C homology domains and Ca(2+)-binding EF hand motifs.

12 tionary time, focusing primarily on the four EF-hand motifs.

13 C-CaM), and within each domain there are two EF-hand motifs.

14 inated proteins through its carboxy-terminal EF-hand motifs.

15 (apo-CaM), despite the zinc binding to both EF-hand motifs.

16 e domains flanking a pair of calcium-binding EF-hand motifs.

17 indin by NMR showing that it consists of two EF-hand motifs.

18 ggesting that the monovalent ions occupy the EF-hand motifs.

19 rized by the presence of two calcium-binding EF-hand motifs.

20 at contains three functional calcium binding EF-hand motifs.

21 Both proteins contain two pairs of EF-hand motifs.

22 st that the bound monovalent ions occupy the EF-hand motifs.

23 ant sequence homology with Cab45 outside the EF-hand motifs.

24 s, and binds Ca2+ due to the presence of six EF-hand motifs.

25 in an L151F missense mutation affecting the EF hand motif 4 (EF4).

26 the +X and -Z positions within each or both EF-hand motifs abolished Ca(2+) binding.

27 )/Mg(2+) binding affinities of parvalbumin's EF-hand motif alter function of cardiac myocytes.

28 The structure consists of four EF-hand motifs although only the first three EF hands ar

29 This domain contains two Ca2+ binding EF hand motifs and has extended similarity to the human

30 ransmembrane helices with a potential single EF-hand motif and four potential SH3-binding motifs in t

31 ) superfamily that harbors two high affinity EF-hand motifs and a C-terminal transmembrane domain.

32 that predicted exon inclusion levels for the EF-hand motifs and for Ca2+-binding residues in nonEF-ha

33 ing protein EfhP (PA4107) with two canonical EF-hand motifs and reported that EfhP mediates Ca(2+) re

34 two structural domains containing a pair of EF-hand motifs and thus switching its partner, guanylyl

35 and flexibility of the linker connecting the EF-hand motifs, and the overall energy balance provide t

36 of the protein; two potential Ca(2+)-binding EF-hand motifs; and a Ser-rich region containing a repea

37 helices entering each loop of the classical EF-hand motif are absent from the dockerin domain.

38 GCAP-2 contains four EF-hand motifs arranged in a compact tandem array like t

39 GCAP3 contains two domains with the EF-hand motifs arranged in a tandem array similar to GCA

40 AM structure (residues 78-256) contains four EF-hand motifs arranged in a tandem linear array, simila

41 inactivation machinery, using the alpha(1C) EF hand motif as a signal transducer to activate the put

42 cid substitution of Trp(647) with Arg in the EF-hand motif associated with a familial case of ASD cau

43 homology (EH) protein-binding domain with an EF-hand motif at the C-terminus.

44 phosphatase in that it contains at least two EF-hand motifs at its carboxy terminus.

45 y of both Aytl1 and -2 proteins that exhibit EF-hand motifs at the C terminus.

46 KIC, with its single EF-hand motif, bound Ca2+ at a physiological concentrati

47 id sequence demonstrated the presence of two EF-hand motifs but identified no canonical DNA binding m

48 The C-terminal tail of hPC2 contains 2 EF hand motifs, but only the second binds calcium.

49 It lacks the EF hand motif characteristic of classical calpains but r

50 pha1C and/or a sequence downstream from this EF-hand motif containing a putative calmodulin (CaM)-bin

51 The structures of the EF-hand motifs containing 11-14 amino acid residues in t

52 ptide systems, Ca2+ affinity is maximized in EF-hand motifs containing four carboxylates positioned o

53 and calmodulin (56% similarity), and has two EF-hand motifs corresponding to the two C-terminal Ca2+

54 y of Ca(2+) signaling in health and disease, EF-hand motifs designed to have new biological activitie

55 enesis, we have shown that disruption of the EF-hand motif does not remove Ca2+ inhibition.

56 Strategic design of new EF-hand motif domains to modulate intracellular Ca(2+) s

57 calcium switch, formed by two tandem pseudo-EF-hand motifs (DxDxD), is present just upstream of the

58 Ca(2+) binding domain encompassing a pair of EF-hand motifs (EF1 and EF2) in the skeletal muscle ryan

59 and Hodges, suggests that the affinity of an EF-hand motif for Ca2+ will be maximal with four acidic

60 However, the importance of this EF-hand motif for channel inactivation has become contro

61 motif or through direct binding to a paired EF hand motif in the Nav1 C terminus.

62 The Ca(2+)-binding EF-hand motif in Cdc24, the Cdc42 activator, was essenti

63 these data suggest that the integrity of the EF-hand motif in Hevin is crucial for proper folding and

64 Furthermore, we identified a Ca(2+)-binding EF-hand motif in the ER-luminal region of junctate.

65 Mutation of the second EF-hand motif in URE3-BP resulted in the loss of calcium

66 We have also shown that all three EF-hand motifs in AtCBL members are required for the int

67 Calcium binds cooperatively to pairs of EF-hand motifs in each domain (N and C).

68 correspond to the second, third, and fourth EF-hand motifs in the protein.

69 To test whether the EF hand motif is truly a calcium sensor controlling PC2

70 Here, an engineered EF- hand motif is incorporated into the central cytoplas

71 cid cluster (VVTL) within the F helix of the EF-hand motif is itself essential for Ca(2+) inactivatio

72 e coordination sequence, Tb(3+) bound to the EF-hand motif is sensitized specifically, and the effici

73 The Cdc24 EF-hand motif is therefore essential for polarity establ

74 rotein was shown to bind calcium through two EF-hand motifs located on its amino terminus.

75 on appears to be a consensus Ca(2+)-binding, EF-hand motif, located approximately 100 amino acids ups

76 of a specific serine residue, S1486, in the EF hand motif of the CaV1.3 subunit.

77 erves as Ca(2+) sensor for inactivation, the EF-hand motif of alpha(1C) may support the transduction

78 The C1 domain plus the EF-hand motif of RasGRP (C1EF-RasGRP) was markedly less

79 ved hydrophobic pocket within the C-terminal EF-hand motifs of CIB as a potential integrin-binding si

80 We also show that the EF-hand motifs of Miro mediate Ca(2+)-dependent arrest o

81 The two non-functional EF-hand motifs of MlcC pack together to form a globular

82 e investigate the effect of mutations in the EF-hand motifs on the Ca(2+) activation of RyR2.

83 We found that mutations in the EF-hand motifs or deletion of the entire EF-hand domain

84 of Medicago truncatula CCaMK, which contains EF-hand motifs, or this domain together with the autoinh

85 ently accepted model of PC2-C consists of an EF-hand motif overlapping with a short coiled coil; howe

86 A server predicts two domains as follows: an EF-hand motif (PC2-EF) connected by a linker to a previo

87 on and contains one canonical and one pseudo-EF-hand motif per monomer, each of which consists of two

88 no acid protein that contains four conserved EF-hand motifs (predicted to be Ca2+-binding domains) an

89 of 10(8) and 10(4) M(-1), respectively, both EF-hand motifs qualify as Ca(2+)/Mg(2+) sites.

90 from Arabidopsis, which contain one and four EF-hand motifs, respectively, bound Ca2+ but did not aff

91 EF34 and Act-EF1234) containing two and four EF-hand motifs, respectively, were produced, and their f

92 typical structure of CaMs, with two pairs of EF-hand motifs separated by a short linker domain.

93 Here, we investigate whether these EF hand motifs serve as a calcium sensor responsible for

94 Here, an EF-hand motif substitution that had been presumed to des

95 nds lanthanides with picomolar affinity at 3 EF hands, motifs that instead bind calcium in most other

96 ation sequences (NLS) as well as a conserved EF-hand motif that binds the Wnt receptor-associated sca

97 The fold consists of a pair of EF hand motifs, the second of which binds tightly to cal

98 proteins contain a putative calcium-binding EF-hand motif, the EFX domain, that interacts with the b

99 toyl group on a long N-terminal arm and four EF-hand motifs, three of which bind Ca2+, assembled into

100 We identified Hevin mutants lacking the EF-hand motif through analyzing ASD-related mice with vu

101 on GCAP-2 exchanged the ability of its first EF-hand motif to bind Ca(2+) for the ability to interact

102 alpha-helix (H6) and the proximal structured EF-hand motif using transition-metal ion fluorescence re

103 Two EF-hand motifs, which are associated with the ability to

104 tic studies indicate both GTPase domains and EF-hand motifs, which are exposed to the cytoplasm, are

105 ily of calcium binding proteins that contain EF-hand motifs, which bind calcium and induce conformati

106 It contains typical EF-hand motifs with Ca2+-binding capability, as confirme