ライフサイエンスコーパス: EHEC

1 EHEC also exhibited the highest total phenolic contents

2 EHEC causes severe bloody diarrhea and hemolytic uremic

3 EHEC colonizes the intestinal tract through a range of v

4 EHEC employs a type III secretion system (T3SS) to trans

5 EHEC encodes the ethanolamine utilization (eut) operon t

6 EHEC encodes the sRNA chaperone Hfq, which is important

7 EHEC harbors SdiA, a regulator that senses acyl-homoseri

8 EHEC soluble factors are sufficient to stimulate macropi

9 EHEC was cleared from the rumen within days and from the

10 ence protein-protein interactions between 15 EHEC effectors and 47 human host proteins.

11 We correlated stx genotypes of 272 EHEC O26 strains isolated in 7 European countries betwee

12 Of the 272 EHEC O26 isolates, 107 (39.3%), 139 (51.1%), and 26 (9.6

13 In addition, EHEC also encodes several non-LEE-encoded effectors and

14 the broadest antimicrobial activity against EHEC and complemented the potency of other colicins.

15 far, there is no vaccine for humans against EHEC infections.

16 group and tested for immunogenicity against EHEC O157:H7 using a murine model of gastrointestinal in

17 sed vaccine, specific for human use, against EHEC is not yet available.

18 In response to AHLs, EHEC represses flagellar genes and the LEE pathogenicity

19 SdiA-AHL chemical signaling aids EHEC in gauging these GI environments, and promotes adap

20 olamine utilization (eut) operon that allows EHEC to metabolize EA and gain a competitive advantage w

21 Furthermore, although EHEC prevalence in produce was highest on farms near are

22 Infection of Swiss cells with an EHEC espW deletion mutant induces a cell shrinkage pheno

23 or developing HUS, such as Shiga toxin 2 and EHEC serotypes traditionally considered to be "high risk

24 strategy of extracellular pathogens EPEC and EHEC and shed light on the complexities of the T3SS effe

25 demonstrating that many provisional EPEC and EHEC isolates incriminated in disease outbreaks are actu

26 EPEC and EHEC not only induce characteristic attaching and effaci

27 ing (A/E) human pathogenic E. coli (EPEC and EHEC) and the natural mouse pathogen Citrobacter rodenti

28 enterohemorrhagic Escherichia coli (EPEC and EHEC) functions to activate transcription of virulence g

29 enterohemorrhagic Escherichia coli (EPEC and EHEC) share a unique mechanism of colonization that resu

30 enterohemorrhagic Escherichia coli (EPEC and EHEC, respectively), which inhibit Src kinase-dependent

31 enterohemorrhagic Escherichia coli (EPEC and EHEC, respectively).

32 enterohemorrhagic Escherichia coli (EPEC and EHEC, respectively).

33 f its better-characterized cousins, EPEC and EHEC.

34 ection of deletions in cryptic prophages and EHEC O157 O-islands to screen for novel regulators of T3

35 iled to distinguish the Shigella species and EHEC isolates from E. coli.

36 roides thetaiotaomicron (Bt), is resident at EHEC attachment sites.

37 Because EHEC does not naturally colonize or cause disease in mic

38 Additionally, because EHEC is largely prevalent in cattle herds, interference

39 EspF sequences differ between EHEC O157:H7, EHEC O26:H11, and EPEC O127:H6 in terms of

40 The genes present in both EHEC EDL933 and Sakai strains but absent in nonpathogeni

41 tant in intestinal colonization of cattle by EHEC serogroup O5, O111, and O26 strains.

42 ve in suppressing disease symptoms caused by EHEC.

43 n shown to foster intestinal colonization by EHEC in some animal models, but the mechanisms responsib

44 pression, would decrease RAJ colonization by EHEC, cattle were challenged at the RAJ with WT or yenI(

45 hrombotic microangiopathy and HUS induced by EHEC Shiga toxins in these preclinical models, and benef

46 stic attaching and effacing (A/E) lesions by EHEC on epithelial cells, is epinephrine dependent.

47 utative fimbrial structures were produced by EHEC cells grown with EA but not in medium lacking EA.

48 ministration, including poloxamer, chitosan, EHEC, xyloglucan, Carbopol, gellan gum and DGG along wit

49 ene expression by enterohemorrhagic E. coli (EHEC) and Citrobacter rodentium, a murine model for EHEC

50 etween intestinal enterohemorrhagic E. coli (EHEC) and extraintestinal uropathogenic E. coli (UPEC),

51 Enterohemorrhagic E. coli (EHEC) are often identified as isolates that are LEE+ and

52 Enterohemorrhagic E. coli (EHEC) is a major cause of large outbreaks worldwide asso

53 Enterohemorrhagic E. coli (EHEC) is an important subset of Shiga toxin-producing (S

54 Enterohemorrhagic E. coli (EHEC) manipulate their human host through at least 39 ef

55 E. coli (EPEC) or enterohemorrhagic E. coli (EHEC) owing to shared traits, most notably the ability t

56 Enterohemorrhagic E. coli (EHEC) responds to AHLs extracted from the bovine rumen.

57 cteria, including enterohemorrhagic E. coli (EHEC), and as it is essential for host colonization by m

58 oximately 250,000 enterohemorrhagic E. coli (EHEC), generic E. coli, and Salmonella tests in produce,

59 ssified as either enterohemorrhagic E. coli (EHEC), typical enteropathogenic E. coli (EPEC), or atypi

60 C), also known as enterohemorrhagic E. coli (EHEC).

61 hagic and enteropathogenic Escherichia coli (EHEC and EPEC), as well as the related mouse pathogen Ci

62 orrhagic and uropathogenic Escherichia coli (EHEC and UPEC), Salmonella typhimurium, and Francisella

63 Enterohemorrhagic Escherichia coli (EHEC) and enteropathogenic E. coli (EPEC) are enteric ba

64 such as enterohemorrhagic Escherichia coli (EHEC) and Salmonella enterica serovar Typhimurium, or th

65 cluding Enterohaemorrhagic Escherichia coli (EHEC) and their inducers remain unknown.

66 rains of enterohemorrhagic Escherichia coli (EHEC) are a group of Shiga toxin-producing food-borne pa

67 ion with enterohemorrhagic Escherichia coli (EHEC) can result in severe disease, including hemorrhagi

68 Enterohemorrhagic Escherichia coli (EHEC) causes hemorrhagic colitis and life-threatening co

69 pathogen enterohemorrhagic Escherichia coli (EHEC) causes severe diarrhea, but the influence of the g

70 types of enterohemorrhagic Escherichia coli (EHEC) emerge constantly, the mechanisms by which these n

71 Enterohemorrhagic Escherichia coli (EHEC) engages a syringe-like machinery named type-III se

72 s during enterohemorrhagic Escherichia coli (EHEC) infection and may exacerbate renal manifestations.

73 ature of enterohemorrhagic Escherichia coli (EHEC) infections is the production of Shiga toxins (Stx)

74 Enterohemorrhagic Escherichia coli (EHEC) is a commonly occurring foodborne pathogen respons

75 Enterohemorrhagic Escherichia coli (EHEC) is a diarrheagenic pathogen that colonizes the gut

76 Enterohemorrhagic Escherichia coli (EHEC) is a food-borne pathogen that can cause severe hea

77 Enterohemorrhagic Escherichia coli (EHEC) is a foodborne pathogen causing hemorrhagic coliti

78 Enterohemorrhagic Escherichia coli (EHEC) is a foodborne pathogen that colonizes the gastroi

79 Enterohemorrhagic Escherichia coli (EHEC) is a significant human pathogen and is the cause o

80 Enterohemorrhagic Escherichia coli (EHEC) is an extracellular pathogen that causes hemorrhag

81 Enterohemorrhagic Escherichia coli (EHEC) is an important foodborne pathogen causing gastroe

82 Enterohemorrhagic Escherichia coli (EHEC) is one of the leading causes of bacterial enteric

83 ecies, 3 enterohemorrhagic Escherichia coli (EHEC) isolates, 2 Yersinia enterocolitica isolates, 2 Ca

84 roducing enterohemorrhagic Escherichia coli (EHEC) O157 in seeded stool samples.

85 Enterohemorrhagic Escherichia coli (EHEC) O157:H7 causes hemorrhagic diarrhea and potentiall

86 pathogen enterohemorrhagic Escherichia coli (EHEC) O157:H7 codes for two interacting DNA binding prot

87 pathogen enterohemorrhagic Escherichia coli (EHEC) O157:H7 colonizes the rectoanal junction (RAJ) in

88 pathogen enterohemorrhagic Escherichia coli (EHEC) O157:H7 has two histidine sensor kinases, QseC and

89 Enterohemorrhagic Escherichia coli (EHEC) O157:H7 is an important food-borne pathogen respon

90 Enterohemorrhagic Escherichia coli (EHEC) O157:H7 responds to the host-produced epinephrine

91 Enterohemorrhagic Escherichia coli (EHEC) O157:H7 strains are major human food-borne pathoge

92 trains of enterohemorragic Escherichia coli (EHEC) O157:H7 that are non-sorbitol fermenting (NSF) and

93 In enterohemorrhagic Escherichia coli (EHEC) O157:H7, EutR responds to ethanolamine to activate

94 focus on enterohemorrhagic Escherichia coli (EHEC) O157:H7, Salmonella, Shigella, Campylobacter, and

95 Enterohemorrhagic Escherichia coli (EHEC) O26 causes diarrhea and hemolytic uremic syndrome

96 Enterohemorrhagic Escherichia coli (EHEC) of serotype O157:H7 has been implicated in food-bo

97 break of enterohemorrhagic Escherichia coli (EHEC) on an open farm infected 93 persons, and approxima

98 Enterohemorrhagic Escherichia coli (EHEC) produce ribosome-inactivating Shiga toxins (Stx1,

99 athogen enterohaemorrhagic Escherichia coli (EHEC) relies on inter-kingdom chemical sensing systems t

100 duced by enterohemorrhagic Escherichia coli (EHEC) require toxin uptake and transcytosis across intes

101 ponse of enterohemorrhagic Escherichia coli (EHEC) to d-serine (d-Ser) resulted in down-regulation of

102 hment of enterohemorrhagic Escherichia coli (EHEC) to intestinal epithelial cells is critical for col

103 ion with enterohemorrhagic Escherichia coli (EHEC) was confirmed in 79% of cases.

104 EhaG from enteropathogenic Escherichia coli (EHEC), and UpaG from uropathogenic E. coli (UPEC), we pr

105 athogens enterohemorrhagic Escherichia coli (EHEC), enteropathogenic E. coli (EPEC), and Citrobacter

106 jejuni, enterohemorrhagic Escherichia coli (EHEC), or Salmonella spp.

107 ncluding enterohemorrhagic Escherichia coli (EHEC), which utilizes the effector protein EspF(U) to as

108 RNAs in enterohemorrhagic Escherichia coli (EHEC).

109 tant for enterohemorrhagic Escherichia coli (EHEC).

110 ctors of enterohemorrhagic Escherichia coli (EHEC).

111 hosts by Enterohemorrhagic Escherichia coli (EHEC).

112 (ImmunoCard STAT! enterohemorrhagic E. coli [EHEC]; Meridian Bioscience) and cultured in attempts to

113 present in nonpathogenic strains of E. coli, EHEC exploits these kinases for virulence regulation.

114 In conclusion, EHEC and WEM have the potential to be used as natural an

115 have previously reported that the conserved EHEC and EPEC effector EspG disrupts recycling endosome

116 In contrast, EHEC adherence to polarized T84 cells occurred independe

117 Actin-dependent EHEC attachment also requires the outer membrane protein

118 he Stx-encoding bacteriophages differentiate EHEC O157 isolates into genogroups commonly isolated fro

119 strointestinal (GI) tract and cause disease, EHEC must be able to sense the host environment and prom

120 e patients show complement activation during EHEC infection, raising the possibility of therapeutic t

121 e cellular immune responses of cattle during EHEC O157:H7 colonization.

122 ndent regulation was necessary for efficient EHEC colonization of cattle fed a grain diet.

123 ess colonization at this site, we engineered EHEC to express the Yersinia enterocolitica AHL synthase

124 We show that Bt enhances EHEC virulence gene expression through the transcription

125 nd enterohaemorrhagic Escherichia coli (EPEC/EHEC) manipulate a plethora of host cell processes to es

126 Upon attachment to intestinal epithelium, EHEC generates "attaching and effacing" (AE) lesions cha

127 nduced Th2 cytokines and production of fecal EHEC sIgA, with pVAX-56.2 reducing EHEC cecum colonizati

128 5 localized to the actin pedestals following EHEC infection.

129 port that DHMA is also a chemoattractant for EHEC.

130 comprise a regulatory circuit important for EHEC colonization of the gastrointestinal tract.

131 nolamine (EA) is an important metabolite for EHEC in the GI tract, and EA is also a signal that EHEC

132 or the surrogate murine infection model for EHEC, Citrobacter rodentium, are all examples of microor

133 nd Citrobacter rodentium, a murine model for EHEC.

134 ely employed as a surrogate animal model for EHEC.

135 Host actin rearrangement necessary for EHEC attachment to enterocytes is mediated by the type 3

136 Here, we show that SdiA is necessary for EHEC colonization of cattle and that AHLs are prominent

137 is different from what has been reported for EHEC strain EDL933 and that the role of Hfq in EHEC viru

138 hing and effacing (AE) lesions requisite for EHEC colonization.

139 The main reservoirs for EHEC are healthy ruminants.

140 Enterohemorrhagic Escherichia coli O157:H7 (EHEC O157) is an important cause of food and waterborne

141 Enterohemorrhagic Escherichia coli O157:H7 (EHEC) causes bloody diarrhea and hemolytic-uremic syndro

142 Enterohemorrhagic Escherichia coli O157:H7 (EHEC) is a foodborne pathogen that causes bloody diarrhe

143 enterohemorrhagic Escherichia coli O157:H7 (EHEC) regulates virulence via the oxygen-responsive smal

144 ype I locus within Escherichia coli O157:H7 (EHEC), which we have named the gene pairs zorO-orzO and

145 enterohemorrhagic Escherichia coli O157:H7 (EHEC).

146 EspF sequences differ between EHEC O157:H7, EHEC O26:H11, and EPEC O127:H6 in terms of the number of

147 ted approximately 50% of all stx2a-harboring EHEC O26 strains isolated between 1996 and 2012.

148 tion and disease are well characterized, how EHEC regulates its expression in response to a host enco

149 nvestigate outbreak-derived animal and human EHEC isolates.

150 rovide a new platform upon which to identify EHEC alterations of host epithelium that contribute to s

151 genomics analysis was performed to identify EHEC-specific antigens useful as potential vaccines.

152 In EHEC strain EDL933, Hfq acts as a negative regulator of

153 In EHEC, YhaJ directly activates expression of type 3 secre

154 mine synthase (GlmS) in E. coli K-12, and in EHEC they destabilize the 3' fragments of the LEE4 and L

155 ly, we mapped the EtrB regulatory circuit in EHEC to determine a global role for EtrB.

156 howed that MC001 is present and conserved in EHEC and in enteropathogenic E. coli (EPEC) strains.

157 S) excision enhancer (IEE) was discovered in EHEC O157:H7 that promoted the excision of IS3 family me

158 this membrane sequestration is disrupted in EHEC that expresses constitutively active GrlA mutants.

159 er, as well as promoters of genes encoded in EHEC-specific O-islands.

160 gulation and reveal a novel role for EutR in EHEC pathogenesis.

161 GAD acid tolerance system but exclusively in EHEC, thereby indirectly enhancing type 3 secretion plei

162 ract and induce virulence gene expression in EHEC, we propose that DHMA acts as a molecular beacon to

163 holine activated fimbrial gene expression in EHEC.

164 EC strain EDL933 and that the role of Hfq in EHEC virulence regulation extends beyond the LEE.

165 We compared these TIR interactions in EHEC and enteropathogenic E. coli (EPEC) and found that

166 two interacting regulators, Cra and KdpE, in EHEC pathogenesis and global gene regulation.

167 ription of several putative fimbrial loci in EHEC.

168 within O-islands (genomic islands present in EHEC but absent from E. coli K-12), such as Z0639, Z0640

169 629, actively transposes and proliferates in EHEC O157:H7 and enterotoxigenic E. coli (ETEC) O139 and

170 The loss of qseD in EHEC does not affect motility, but the K-12 Delta qseD m

171 m signaling and virulence gene regulation in EHEC, as well as an increase in expression of stx(2AB),

172 owledge of posttranscriptional regulation in EHEC.

173 cate that QseA acts as a global regulator in EHEC, co-ordinating expression of virulence genes.

174 indicate that Hfq plays a regulatory role in EHEC 86-24 that is different from what has been reported

175 Here, we compared the SdiA role in EHEC colonization of cattle fed a forage hay diet.

176 ein renamed EtrB, plays an important role in EHEC pathogenesis.

177 Comparable metabolic changes are seen in EHEC DeltaqseC, suggesting that deletion of qseC confers

178 We showed that in EHEC, epinephrine sensing seems to occur primarily throu

179 ecAP-cfp) and Stx1 production (stx1::yfp) in EHEC O157:H7 EDL933.

180 k grazing, we found no evidence of increased EHEC, generic E. coli, or Salmonella near nongrazed, sem

181 ion of HeLa cells with epinephrine increases EHEC infectivity in a QseC- and QseE-dependent manner.

182 We rapidly isolated multiple, independent, EHEC mutants whose growth was no longer compromised in t

183 Exogenously added arginine induces EHEC virulence gene expression in vitro.

184 Here, we report that EA influenced EHEC adherence to epithelial cells and fimbrial gene exp

185 In this study, we investigated EHEC adherence to the human colon by using in vitro orga

186 al colicins are highly effective against key EHEC strains.

187 Shiga toxins (Stx) are the key EHEC virulence determinant contributing to severe diseas

188 tegories, the ethanol extract of curry leaf (EHEC) and the water extract of mint leaf (WEM) showed hi

189 the outer membrane protein intimin, a major EHEC adhesin.

190 showed very high activity against all major EHEC strains, as defined by the US Department of Agricul

191 LEE transcriptional activator GrlA mediates EHEC's response to mechanical cues characteristic of the

192 ade available by the microbiota, to modulate EHEC pathogenicity and metabolism.

193 lved in the development of disease in murine EHEC infection.

194 C. rodentium NleB, EHEC NleB1, and SseK1 glycosylated host GAPDH.

195 C. rodentium NleB, EHEC NleB1, EPEC NleB1, and SseK2 glycosylated the FADD

196 55:H7 (SOR(+) GUD(+)) strains, two nonmotile EHEC O157:H(-) strains (SOR(+) GUD(+)) containing plasmi

197 In nonstimulated EHEC, wild-type GrlA associates with cardiolipin membran

198 In addition, seven novel EHEC-specific sRNAs were identified using RNA sequencing

199 d espW in the sequenced O157:H7 and non-O157 EHEC strains as well as in Shigella boydii Furthermore,

200 Most EPEC and non-O157 EHEC strains express lymphostatin (also known as LifA),

201 was no difference between O157 and non-O157 EHEC.

202 Five years after diagnosis, 70% of EHEC-infected patients (95% confidence interval [CI], .6

203 is study, we have explored the adaptation of EHEC to d-Ser and its consequences for pathogenesis.

204 Further analysis of EHEC secreted proteins shows that a serine protease EspP

205 We investigated the global changes of EHEC gene expression governed by GlmY and GlmZ using RNA

206 A new highly virulent clone of EHEC O26 has emerged in Europe.

207 y plasmid genes to the new virulent clone of EHEC O26 that emerged in Germany in the 1990s.

208 RAJ is the prominent site of colonization of EHEC in cattle.

209 and that provides spatiotemporal control of EHEC virulence.

210 nces in the pathogenesis and epidemiology of EHEC strains.

211 e to cultured cells as well as expression of EHEC secreted protein A (EspA).

212 In addition, DHMA induces the expression of EHEC virulence genes and increases attachment to intesti

213 modulating the virulence gene expression of EHEC.

214 d CG share the cardinal virulence factors of EHEC O157 and are carried by cattle at similar prevalenc

215 A defining feature of EHEC pathogenesis is the formation of attaching and effa

216 Cattle are a reservoir host of EHEC O157 and a major source of human exposure through c

217 espite the magnitude of the social impact of EHEC infections, no licensed vaccine or effective therap

218 Toxin macropinocytosis is independent of EHEC type 3 secretion and intimin attachment.

219 ate was able to reduce the bacterial load of EHEC O157:H7 strain in feces, colon and caecum tissues a

220 orphism (SNP) is observed in the majority of EHEC O157:H7 isolates and correlates with a negative ure

221 ntact ure locus, ureDABCEFG, the majority of EHEC strains are phenotypically urease negative under te

222 protects mice from disease manifestations of EHEC.

223 P3) inflammasome as an essential mediator of EHEC-induced IL-1beta.

224 pathogen Citrobacter rodentium as a model of EHEC virulence to investigate the importance of EutR in

225 Models of EHEC infection in conventional mice do not manifest key

226 -56.2), was able to induce the production of EHEC IgG and sIgA in sera and feces.

227 The virulence repertoire of EHEC includes the genes within the locus of enterocyte e

228 that is central to the niche restriction of EHEC.

229 rectum, the predominant colonization site of EHEC O157 in cattle and a site containing M-like cells.

230 esults is that a single successful strain of EHEC spread from a single introduction through the farm

231 A number of other strains of EHEC in addition to O157:H7 are emerging as serious thre

232 that block the functionality of the T3SS of EHEC.

233 txs) are an important pathogenicity trait of EHEC O157.

234 mediates to positively regulate virulence of EHEC.

235 ffacing (A/E) lesions which are dependent on EHEC type III secretion (T3S) and binding of the outer m

236 nt of epinephrine and its sensors' impact on EHEC virulence, we performed transcriptomic and phenotyp

237 , but the influence of the gut microbiota on EHEC infection is largely unknown.

238 R(+) GUD(+)) containing plasmid pSFO157, one EHEC O157:H7 (SOR(-) GUD(+)) strain, and one O157:H7 str

239 Risk estimates for Salmonella or EHEC-related AGI were most sensitive to the assumed leve

240 4:H4 outbreak and 32 'negative' non-outbreak EHEC isolates indicated that individual primer sets exhi

241 was proposed in which the highly pathogenic EHEC O157:H7 serotype arose from its ancestor, enteropat

242 The Premier EHEC assay and SMAC culture detected 96.0% and 58.0% of

243 tested by both SMAC culture and the Premier EHEC assay at Children's Hospital Boston.

244 The Premier EHEC assay was significantly more sensitive than SMAC cu

245 ostic utility of SMAC to that of the Premier EHEC enzyme immunoassay (Meridian Diagnostics) for detec

246 candidates potentially useful for preventing EHEC O157:H7 infections.

247 lutamate acid resistance (gad) genes priming EHEC's acid resistance before they pass into the acidic

248 s bacteriophage-encoded "anti-sRNA" provided EHEC with a growth advantage specifically in bovine rect

249 of fecal EHEC sIgA, with pVAX-56.2 reducing EHEC cecum colonization.

250 complicated by other, potentially redundant EHEC-encoded binding pathways, so we utilized cell bindi

251 R based tests with other clinically relevant EHEC isolates showed similar results for both Stx1 and S

252 fucose-sensing system is required for robust EHEC colonization of the mammalian intestine.

253 ensitivity and reliably detected Salmonella, EHEC O157, Shigella, and Campylobacter at concentrations

254 there is no direct clinical evidence showing EHEC binding to the colonic epithelium in patients.

255 o a range of chemical environmental signals, EHEC is capable of sensing and responding to mechanical

256 SseK1, SseK3, EHEC NleB1, EPEC NleB1, and Crodentium NleB blocked TNF-

257 stinct from previously reported O157:H7 ST11 EHEC and was not a member of the hypervirulent clade 8.

258 flammasome activation, delivery of synthetic EHEC RNA:DNA hybrids into the cytosol triggered NLRP3-de

259 We have recently demonstrated that EHEC infection of intestinal epithelial cells stimulates

260 We previously demonstrated that EHEC senses acyl-homoserine lactones (AHLs) produced by

261 to other bacteria and viruses we found that EHEC effectors bind more frequently to hub proteins as w

262 We found that EHEC in fresh produce increased by more than an order of

263 We also found that EHEC NleB1 glycosylated two GAPDH arginine residues, Arg

264 Here, we report that EHEC perceives attachment to host cells as a mechanical

265 n the GI tract, and EA is also a signal that EHEC uses to activate virulence traits.

266 Our findings suggest that EHEC uses fucose, a host-derived signal made available b

267 Our study suggests that EHEC colonizes and forms stable A/E lesions on the human

268 We show for the first time that EHEC colonizes human colonic biopsy samples by forming t

269 Previously, in the EHEC O157:H7 Sakai strain, a point mutation in ureD, enc

270 Here, we deleted hfq in the EHEC strain 86-24 and compared global transcription prof

271 within bacteriophage-derived regions of the EHEC genome, including some of the most abundant Hfq-int

272 ions, DicF enhances global expression of the EHEC type three secretion system, which is a key virulen

273 lecular epidemiology data was applied on the EHEC O157:H7 genome to select new potential vaccine cand

274 We show that the EHEC and EPEC NleH effectors are functionally equivalent

275 acteria to mammalian cells by binding to the EHEC outer surface protein Intimin.

276 EC challenge and every other day thereafter, EHEC colonization was suppressed and mice were significa

277 Comparative analysis of the three EHEC plasmids shows that pO157-2 is highly related to pO

278 ion to suggesting that Lpf can contribute to EHEC intestinal colonization, our observations indicate

279 in mucin, B. thetaiotaomicron contributes to EHEC virulence by cleaving fucose from mucin, thereby ac

280 se model of renal and enteric disease due to EHEC to determine if probiotic Lactobacillus reuteri ATC

281 disease; however, the importance of EutR to EHEC intestinal infection has not been examined.

282 tium, a natural mouse pathogen homologous to EHEC, in Bt-reconstituted mice results in increased gut

283 n L. reuteri was administered 1 day prior to EHEC challenge and every other day thereafter, EHEC colo

284 the two adrenergic sensors QseC and QseE to EHEC pathogenesis.

285 ional inhibitors may be of value in treating EHEC infections.

286 Here we used EHEC genomic DNA as a template to amplify and assemble a

287 o investigate the importance of EutR in vivo EHEC and C. rodentium possess the locus of enterocyte ef

288 Whereas EHEC-specific virulence factors were dispensable for NLR

289 ssembly or by infecting mammalian cells with EHEC mutants that translocate Tir but are specifically d

290 weaned mice receiving an oral challenge with EHEC were completely protected by the transference of im

291 fed either grain or hay and challenged with EHEC orally carried the bacteria similarly.

292 deposits in the renal biopsy of a child with EHEC-associated hemolytic uremic syndrome.

293 ar immune responses during colonization with EHEC O157:H7, the temporality of which is strain depende

294 The pork meat samples treated with EHEC and WEM showed a decrease in the Hunter L- and a-va

295 nscriptome analyses comparing wild-type (WT) EHEC and the qseA mutant to elucidate QseA's role in gen

296 ere challenged at the RAJ with WT or yenI(+) EHEC.

297 The yenI(+) EHEC also activated expression of the gad genes.

298 Although the yenI(+) EHEC colonized the RAJ with efficiency equal to that of

299 The yenI(+) EHEC produces oxo-C6-homoserine lactone (oxo-C6-HSL) and

300 o shed the WT strain longer than the yenI(+) EHEC.