ライフサイエンスコーパス: ER membrane

1 ing ULK and FIP200 first associates with the ER membrane.

2 is sequestered in increasing amounts at the ER membrane.

3 5 was previously shown to associate with the ER membrane.

4 ote the release of active p110 Nrf1 from the ER membrane.

5 bodies, or PBs) and stress granules, and the ER membrane.

6 vesicles, while Anks1a remains behind on the ER membrane.

7 teins are translated when they encounter the ER membrane.

8 eract and form low-mobility oligomers in the ER membrane.

9 ion-competent virion capable of crossing the ER membrane.

10 of calnexin to the retention of PTP1B at the ER membrane.

11 igher eukaryotes causes LDs to remain in the ER membrane.

12 ontaining ectodomains if not anchored at the ER membrane.

13 nect these lumenal events with events on the ER membrane.

14 nds and cleaves the majority of mRNAs at the ER membrane.

15 ciated role for this ubiquitin ligase at the ER membrane.

16 V) and SYTA directly interacted caged within ER membrane.

17 mpetent state until it is ready to cross the ER membrane.

18 on is coordinated on the lumenal side of the ER membrane.

19 ty to limit mechanical stress imposed on the ER membrane.

20 om SV40 to enable the virus to penetrate the ER membrane.

21 atidylinositol-3-phosphate appearance at the ER membrane.

22 phospholipids that are also abundant in the ER membrane.

23 3 (SH3) domain and DHHC6 is localized to the ER membrane.

24 sociated with the endoplasmic reticulum (ER)/ER membrane.

25 a fragment that is no longer tethered to the ER membrane.

26 of STING and innate immune signalling at the ER membrane.

27 mediated by Na(+)/Ca(2+) exchange across the ER membrane.

28 oop of an ERAD-L substrate moves through the ER membrane.

29 ns, BMB2 adopts a W-like topology within the ER membrane.

30 hering of Golgi-derived COPI vesicles at the ER membrane.

31 eplication and assembly on the LD-associated ER membrane.

32 ontrol the structure and the dynamics of the ER membrane.

33 ng, recruits the other COPII proteins to the ER membrane.

34 n as it emerges at the cytosolic face of the ER membrane.

35 w this vital ATP transport occurs across the ER membrane.

36 conserved protein-conducting channel in the ER-membrane.

37 coordinated action of RHD3 in the fusion of ER membranes.

38 We show that native IP3Rs cluster within ER membranes.

39 ding domain of NS1, which can associate with ER membranes.

40 associated Get1/2 complex for insertion into ER membranes.

41 to translocon-engaged 60S subunits on native ER membranes.

42 1 and subsequently impaired its activity at ER membranes.

43 likely involve binding to mitochondrial and ER membranes.

44 e lipid droplets closely associated with the ER membranes.

45 enic C2C12 cells, P-Panx3 was located on the ER membranes.

46 m the ribosome to the endoplasmic reticulum (ER) membrane.

47 sphatidic acid at the endoplasmic reticulum (ER) membrane.

48 tophagosomes from the endoplasmic reticulum (ER) membrane.

49 e (TM) segment in the endoplasmic reticulum (ER) membrane.

50 zyme localized to the endoplasmic reticulum (ER) membrane.

51 mplex residing in the endoplasmic reticulum (ER) membrane.

52 ss cholesterol in the endoplasmic reticulum (ER) membrane.

53 which resides in the endoplasmic reticulum (ER) membrane.

54 brane proteins at the endoplasmic reticulum (ER) membrane.

55 on the LD-associated endoplasmic reticulum (ER) membrane.

56 ed (TA) proteins into endoplasmic reticulum (ER) membranes.

57 rectly engage with putative substrate at the ER membrane, a function canonically assigned to Cdc48.

58 ration from the presumably uniformly fluidic ER membrane, a previously unknown phenomenon.

59 und that cell death coincides with collapsed ER membrane, although we cannot rule out other possible

60 AspH is an endoplasmic reticulum (ER) membrane-anchored 2-oxoglutarate oxygenase whose C-t

61 tein quality control machinery to breach the ER membrane and access the cytosol, a decisive infection

62 PAWH1 and PAWH2 localize to the ER membrane and associate with Hrd1 via EMS-mutagenized

63 T-1S113R is unable to form homodimers in the ER membrane and is devoid of acetyl-CoA transport activi

64 Protein translocation across the ER membrane and N-glycosylation are highly coordinated p

65 his, a mutant SV40 that cannot penetrate the ER membrane and promote infection fails to induce C18 fo

66 ) quality control machinery to penetrate the ER membrane and reach the cytosol, a critical infection

67 Mechanistically, Tmem178 localizes to the ER membrane and regulates RANKL-induced Ca(2+) fluxes, t

68 lization and distribution of CerS within the ER membrane and that phosphorylation of these sites is f

69 find that the MYRF proteins localize to the ER membrane and that they are cleaved into active N-term

70 Ds originate from the endoplasmic reticulum (ER) membrane and are mainly composed of a triglyceride (

71 ssed primarily on the endoplasmic reticulum (ER) membrane and primary cilia of all cell and tissue ty

72 M1 associated with STING to retain it in the ER membrane, and coexpression of full-length STIM1 or a

73 ey are polyubiquitinated, extracted from the ER membrane, and degraded by the proteasome.

74 lti-pass integral membrane proteins into the ER membrane, and it is also responsible for inserting th

75 nding domain (DBD), is auto-cleaved from the ER membrane, and then enters the nucleus to participate

76 SOD1, its association with mitochondrial and ER membranes, and the levels of sedimentable insoluble S

77 The expanded ER membranes are formed due to deletion of a lipin homol

78 esterol levels in the endoplasmic reticulum (ER) membrane are high, but the signal for degradation wa

79 unctioned in vivo to insert TA proteins into ER membranes as demonstrated by the fact that the YFP-ta

80 containing actin-binding domains, is a novel ER membrane-associated actin-binding protein.

81 The conserved ER membrane-associated BAX inhibitor 1 (BI1) modulates E

82 IRE1alpha, an ER membrane-associated protein mediating unfolded protei

83 ress the myelin regulatory factor (MYRF), an ER membrane-associated transcription factor (TF) release

84 we further unveil reduced diffusivity in the ER membrane at ER-plasma membrane contact sites.

85 d role for Get4/5 in recycling Get3 from the ER membrane at the end of the targeting reaction.

86 rier in the form of a distinct domain of the ER-membrane at the bud neck, in a septin-, Bud1 GTPase-

87 pecialized patches of endoplasmic reticulum (ER) membrane away from the ER-Golgi interface.

88 cating that a diffusion barrier forms in the ER membrane between these two domains.

89 ER and UFMylated RPL26 is highly enriched on ER membrane-bound ribosomes and polysomes.

90 that control global proteome composition via ER membrane-bound ribosomes.

91 40) hijacks the three endoplasmic reticulum (ER) membrane-bound J proteins B12, B14, and C18 to escap

92 R is not by acquisition of a larger patch of ER membrane, but instead by addition of ERGIC membranes

93 They localize in the ER membranes, but their cellular function remains unclea

94 nally, mature autophagosomes detach from the ER membrane by an as yet unknown mechanism, undergo intr

95 le-based motor kinesin-1 is recruited to the ER membrane by binding to the transmembrane J-protein B1

96 As a consequence, VKORC1 exits the ER membrane by cellular quality control systems and resu

97 rapid capture of newly synthesized LD at the ER membrane by nascent autophagosomal structures.

98 se, TorsinA and TorsinB, are anchored to the ER membrane by virtue of an N-terminal hydrophobic domai

99 s are produced at the endoplasmic reticulum (ER) membrane by a multicomponent enzyme complex termed c

100 or inserted into the endoplasmic reticulum (ER) membrane by the ER protein translocon.

101 penetrates a virus-induced structure in the ER membrane called "focus" to reach the cytosol, where i

102 rt by constructing a penetration site on the ER membrane called a 'focus'.

103 14 to reorganize into discrete puncta in the ER membrane called foci, structures postulated to repres

104 the formation of punctate structures in the ER membrane, called foci, that serve as the portal for c

105 ith intramembrane hairpin domains that model ER membranes, cause an axon degenerative disease, heredi

106 The protein localizes to the ER membrane, coexpresses with AtGET1, and binds to Arabi

107 We show that loss of the ER membrane complex (EMC) or mutation of the Sec61 trans

108 howed that this ERAD branch is defined by an ER membrane complex consisting of the ubiquitin ligase R

109 The endoplasmic reticulum (ER) membrane complex (EMC) cooperates with the Sec61 tra

110 tmentalization of the endoplasmic reticulum (ER) membrane confine protein deposit formation to aging

111 sion and fusion are spatially coordinated at ER membrane contact sites (MCSs).

112 itol-3-phosphate (PtdIns(3)P) production and ER membrane curvature formation, thus inducing COPII-med

113 helix in SM N100 attaches reversibly to the ER membrane depending on cholesterol levels; with excess

114 tion in mouse cardiac myocytes results in SR/ER membrane destabilization and luminal vacuolization al

115 n formations of hypertrophied tightly packed ER membranes devoted to specific biosynthetic and secret

116 calization, constitutively targeting Rheb to ER membranes did not support mTORC1 activation.

117 dation ubiquitin ligases (E3s) reside in the ER membrane, Doa10 and Hrd1.

118 ht to channel misfolded proteins through the ER membrane during retrotranslocation.

119 ants, suggesting that ESCRTs restrict excess ER membranes during NE closure.

120 proteins, across the endoplasmic reticulum (ER) membrane during or after translation.

121 Yeast ERAD employs two integral ER membrane E3 Ub ligases: Hrd1 (also termed "Der3") and

122 etachment of the Hsp40 protein Ydj1 from the ER membrane elicited a similar phenotype, suggesting tha

123 itional, and Teb4, an endoplasmic reticulum (ER) membrane-embedded ubiquitin ligase, was able to regu

124 cystin-2 (PC2) at the endoplasmic reticulum (ER) membrane, enhancing its opening over the whole physi

125 ompartmentalization of this process to rough ER membrane ensures enrichment of miRNA-targeted message

126 e misfolded part, the ER lumen (ERAD-L), the ER membrane (ERAD-M), and the cytosol (ERAD-C).

127 When cholesterol in ER membranes exceeds a threshold, the sterol binds to Sc

128 ut likely is the direct result of changes in ER membrane fluidity and composition.

129 rated phospholipids, which ultimately reduce ER membrane fluidity.

130 ocation of misfolded polypeptides across the ER membrane for ER-associated degradation (ERAD).

131 rsor protein into the endoplasmic reticulum (ER) membrane for subsequent routing to the cell surface.

132 We showed that efficient ER membrane fusion mediated by RHD3 requires a proper di

133 oring ability that is required for efficient ER membrane fusion mediated by RHD3.

134 IVE3 (RHD3) has been demonstrated to mediate ER membrane fusion, but how exactly RHD3 is involved in

135 in proteins (ATL1, -2, and -3), which induce ER membrane fusion, facilitate ZIKV replication.

136 atically validate yeast mutants that disrupt ER membrane homeostasis, we identified a lipid bilayer s

137 e kinase localized in close proximity to the ER membrane in cardiomyocytes.

138 xchanger, CalX, which we immuno-localized to ER membranes in addition to its established localization

139 Defects in the ER membrane induce the UPR, and the UPR in turn controls

140 mediated by Na(+)/Ca(2+) exchange across the ER membrane induced by Na(+) influx via the light-sensit

141 e nucleotides cannot cross mitochondrial and ER membranes, inhibiting mitochondrial function with an

142 Our studies reveal that although ER membrane integrity may be threatened during ER escape

143 morphogenic protein reticulon (RTN) protects ER membrane integrity when polyomavirus SV40 escapes the

144 ing the diffusion barriers that separate the ER membrane into mother and bud compartments caused prem

145 h membrane curvature, thus helping shape the ER membrane into tubules.

146 through lipin to prevent invasion of excess ER membranes into NE holes and a defective NE permeabili

147 us, regulating the production and feeding of ER membranes into NE holes together with ESCRT-mediated

148 uitinated, reductase becomes dislocated from ER membranes into the cytosol for degradation by 26 S pr

149 ent spherules that were invaginations of the ER membranes into the lumen.

150 Together, our data indicate that the ER membrane is compartmentalized in cells as diverse as

151 However, how the ER membrane is involved in autophagy initiation and to w

152 a SERCA-dependent Ca(2+) gradient across the ER membrane is necessary for ATP transport into the ER,

153 ecise mechanism of how the toxin crosses the ER membrane is unknown.

154 Association with the endoplasmic reticulum (ER) membrane is a critical requirement for the catalytic

155 ne Ubiquilin4 (Ubqln4) binds directly to the ER membrane J proteins B12 and B14.

156 chanism involving its phosphorylation by the ER membrane kinase PERK.

157 otein response (UPR) exclusively when normal ER membrane lipid composition is compromised, we identif

158 -Syt2 positions the ER and Sac1, an integral ER membrane lipid phosphatase, in discrete ER-PM junctio

159 re, we report that MfSTMIR, which encodes an ER-membrane-localized RING E3 ligase that is highly cons

160 c61 mediates the release of beta-DG from the ER membrane, making it accessible for importins and nucl

161 ssociation with the mitochondrion-associated ER membrane (MAM) and mitochondrial proteins.

162 The mitochondria-associated ER membrane (MAM) plays a critical role in cellular ener

163 Ms in the ER, called mitochondria-associated ER membranes (MAM).

164 ondrial tethering at mitochondria-associated ER membranes (MAM).

165 tochondria-associated endoplasmic reticulum (ER) membranes (MAM) and that ER-mitochondrial connectivi

166 tochondria-associated endoplasmic reticulum (ER) membranes (MAM), a structurally and functionally dis

167 by complexes called Mitochondria-Associated ER Membranes (MAMs), is known to play an important role

168 microdomains called mitochondria-associated ER membranes (MAMs), where their membranes are in close

169 at sites defined as mitochondria-associated ER membranes (MAMs), which are essential for calcium, li

170 culum (ER), known as mitochondria-associated ER membranes (MAMs).

171 tochondria-associated endoplasmic reticulum (ER) membranes (MAMs) are functional domains between both

172 Co-localization with an ER membrane marker showed that mCherry-AtCEP2 was stored

173 Desaturation of the ER membrane may serve as an auxiliary signal of the fed

174 the degradation pathways of two short-lived ER membrane model proteins in mammalian cells.

175 lls, it is logically assumed that defects in ER membrane morphogenesis due to impaired fusion activit

176 0 prevents proinsulin aggregation, while the ER membrane morphogenic protein reticulon-3 (RTN3) dispo

177 ly protein NBK/Bik on endoplasmic reticulum (ER) membranes, most likely by blocking loading and autop

178 ions in the degradation of substrates in the ER membrane, nuclear envelope, cytoplasm, and nucleoplas

179 ntegral membrane proteins across or into the ER membrane occurs via the evolutionarily conserved Sec6

180 asmic reticulum (ER; mitochondria-associated ER membranes or 'MAM').

181 or catalyzing the most proximal event before ER membrane penetration of PyVs.

182 These foci, postulated to represent the ER membrane penetration site, harbor ER components, incl

183 Prior to ER membrane penetration, ER lumenal factors impart struc

184 r data illuminate C18's contribution to SV40 ER membrane penetration, strengthening the idea that SV4

185 se treated with saponin (plasma membrane and ER membrane permeabilized), BeauIII inhibited SOAT1 (IC5

186 nonequilibrium metabolic activity modulates ER membrane phase has not been investigated.

187 er when comparing the endoplasmic reticulum (ER) membrane, plasma membrane, and nanodomains induced b

188 Cholesterol accumulation in ER membranes prevents Scap transport and decreases chole

189 The deposits localized to the ER membrane, primarily to the nuclear envelope (NE).

190 ne to trigger extraction of reductase across ER membranes prior to its cytosolic release.

191 ochondrion-associated endoplasmic reticulum (ER) membrane programs antiviral signaling.

192 Because Selk is also an ER membrane protein and contains an SH3 binding domain,

193 In this study, we clarify the role of an ER membrane protein called C18 in mobilizing the simian

194 cumulates at the MAM by associating with the ER membrane protein calnexin.

195 We find that a member of the ER membrane protein complex (EMC) called EMC1 promotes S

196 missing multiple components of the conserved ER membrane protein complex (EMC) has decreased phosphat

197 Structural homology with YidC and the ER membrane protein complex (EMC) implicates an evolutio

198 Here, we show that the ER membrane protein complex (EMC) is indispensable for t

199 Here we find that EMC4 and EMC7, two ER membrane protein complex (EMC) subunits, support SV40

200 oplasmic reticulum (ER), where the conserved ER membrane protein complex (EMC) was shown to be essent

201 The ER membrane protein complex (EMC), comprising eight cons

202 Dubbed the ER membrane protein complex (EMC), its disruption has si

203 onal changes enable SV40 to engage BAP31, an ER membrane protein essential for supporting membrane pe

204 present in a stoichiometric complex with the ER membrane protein Hrd3, which is also required for HRD

205 on of the ER depends on the highly conserved ER membrane protein Jagunal (Jagn).

206 t the yeast seipin Fld1, in complex with the ER membrane protein Ldb16, prevents equilibration of ER

207 hatidic acid (PA) and the conserved integral ER membrane protein Scs2p regulate localization of the t

208 The ER membrane protein Scs2p tethers the cER to the PM and

209 hway requires the Sec translocase-associated ER membrane protein Sec62 and can be uncoupled from tran

210 ignaling, and interactions of vIL-6 with the ER membrane protein vitamin K epoxide reductase complex

211 nd vIL-6 with the previously uncharacterized ER membrane protein vitamin K epoxide reductase complex

212 th the gp130 signal transducer and the novel ER membrane protein vitamin K epoxide reductase complex

213 ansduction and interaction of vIL-6 with the ER membrane protein VKORC1v2.

214 Here, we report a cardiac enriched, SR/ER membrane protein, REEP5 that is centrally involved in

215 is synthesized as an endoplasmic reticulum (ER) membrane protein and when cellular proteasome activi

216 The nine-subunit endoplasmic reticulum (ER) membrane protein complex (EMC) is a conserved co- an

217 The endoplasmic reticulum (ER) membrane protein complex (EMC) was identified over a

218 mbrane depends on the endoplasmic reticulum (ER) membrane protein complex (EMC).

219 ession, including the endoplasmic reticulum (ER) membrane protein complex transmembrane insertase.

220 MEM41B is an integral endoplasmic reticulum (ER) membrane protein distantly related to the establishe

221 rboxy terminus of the endoplasmic reticulum (ER) membrane protein Shr3.

222 pressed transmembrane endoplasmic reticulum (ER) membrane protein that has previously been implicated

223 racts with Erlin2, an endoplasmic reticulum (ER) membrane protein that is located in lipid rafts and

224 is a type I integral endoplasmic reticulum (ER) membrane protein, molecular chaperone, and a compone

225 show that ERG-28, an endoplasmic reticulum (ER) membrane protein, promotes the trafficking of SLO-1

226 codes a member of the endoplasmic reticulum (ER)-membrane protein complex (EMC), an evolutionarily co

227 e results from its sterol-induced binding to ER membrane proteins called Insig-1 and Insig-2.

228 (2020) showed that unassembled ER membrane proteins diffuse to the INM for degradation.

229 gnaling pathways activated downstream of the ER membrane proteins IRE1, ATF6, and PERK.

230 Here, we describe the ER membrane proteins REEP3 and REEP4 as major determinan

231 These included the ER membrane proteins VAPA and VAPB and lipid transfer pr

232 ed a novel, evolutionarily diverse family of ER membrane proteins with StART-like lipid transfer doma

233 Multispanning ER membrane proteins, called ERAD-M substrates, are retr

234 y is homeostatically regulated through small ER membrane proteins, the Orms in yeast and the ORMDLs i

235 eased expression of mitochondrial-associated ER membrane proteins, which favor cholesterol translocat

236 oteome through the clearance of mislocalized ER membrane proteins.

237 ecognition and ubiquitination of unassembled ER membrane proteins.

238 (RTNs) are a class of endoplasmic reticulum (ER) membrane proteins that are capable of maintaining hi

239 and SOAT2), which are endoplasmic reticulum (ER) membrane proteins, in an enzyme-based assay, and sel

240 oteins that can form complexes with integral ER-membrane proteins, thereby potentially influencing th

241 Ds form lens-like structures that are in the ER membrane, raising the question of how these nascent L

242 Here, we demonstrated that ER membrane receptors VAPA and VAPB are involved in modu

243 (E3s) embedded in the endoplasmic reticulum (ER) membrane regulate essential cellular activities incl

244 he ER chaperone Kar2/BiP fused to GFP and an ER membrane reporter, Hmg1-GFP, behave differently in th

245 iP co-chaperones, ERj3 and ERj6, but not the ER membrane-resident co-chaperones (such as Sec63 protei

246 In S. pombe, the ER membrane-resident kinase/endoribonuclease Ire1 utiliz

247 Two ER membrane-resident transmembrane kinases, IRE1 and PER

248 The endoplasmic reticulum (ER) membrane-resident stress sensor inositol-requiring e

249 bilizes autophagy, which sequesters stressed ER membranes, resolves ER stress, and curtails phagocyte

250 oughout their life cycle, and degradation of ER membranes restricts flavivirus replication.

251 cks the translocation of tetherin across the ER membrane, resulting in cytosolic accumulation of a no

252 phasis on the role of the recently described ER membrane signaling mechanisms.

253 providing the first quantitative analysis of ER membrane structure and dynamics at the nanoscale, our

254 al that GPRC5A at the endoplasmic reticulum (ER) membrane suppresses synthesis of the secreted or mem

255 tion and oligomerization, creating localized ER membrane tensions that result in membrane curvature.

256 This insight indicates that the ER membrane tethering machinery in plant cells could pla

257 and revealed DHHC6/Selk interactions in the ER membrane that depended on SH3/SH3 binding domain inte

258 polytopic protein of endoplasmic reticulum (ER) membranes that transports sterol regulatory element-

259 which has been suggested to localize to the ER membrane, the ER-derived quality control compartment

260 howed that following ribosome docking on the ER membrane, the nascent polypeptide was shielded from t

261 STIM1, located in the endoplasmic reticulum (ER) membrane, the calcium channel ORAI1 in the plasma me

262 In endoplasmic reticulum (ER) membranes, the carboxyl-terminal domain (CTD) of SRE

263 e1 also cleaves other mRNAs localized to the ER membrane through regulated Ire1-dependent decay (RIDD

264 n the availability of endoplasmic reticulum (ER) membranes throughout their life cycle, and degradati

265 fungi, acts as a lipid-packing sensor in the ER membrane to control the production of unsaturated fat

266 e activated, IRE1alpha recruits TRAF2 to the ER membrane to initiate inflammatory responses via the N

267 nsor proteins able to translocate within the ER membrane to physically couple with and gate plasma me

268 smic reticulum (ER), where it penetrates the ER membrane to reach the cytosol before mobilizing into

269 eloped polyomavirus SV40, penetration of the ER membrane to reach the cytosol is a decisive virus inf

270 l, this virus family must penetrate the host ER membrane to reach the cytosol, a critical entry step.

271 l surface to the ER, where it penetrates the ER membrane to reach the cytosol.

272 d proteins activate UPR signaling across the ER membrane to the nucleus by promoting oligomerization

273 show that XendoU functions on the surface of ER membranes to promote RNA cleavage and ribonucleoprote

274 st penetrate the host endoplasmic reticulum (ER) membrane to enter the cytosol in order to promote in

275 outer leaflet of the endoplasmic reticulum (ER) membrane to maintain cytosolic LD emergence and prev

276 virus penetrates the endoplasmic reticulum (ER) membrane to reach the cytosol and then traffics to t

277 s SV40 penetrates the endoplasmic reticulum (ER) membrane to reach the cytosol, a crucial infection s

278 idae, invaginates the endoplasmic reticulum (ER) membranes to form spherules in infected cells.

279 nome is translated on endoplasmic reticulum (ER) membranes to produce a single polyprotein, which is

280 R lumenal factors that prepare the virus for ER membrane translocation and connect these lumenal even

281 nal factors that coordinately prime SV40 for ER membrane translocation and establishes a functional c

282 s domain appears to exert an unexpected post-ER membrane translocation function during SV40 entry.

283 tein complex (EMC) called EMC1 promotes SV40 ER membrane transport and infection.

284 isulfide bonds, a reaction important for its ER membrane transport and infection.

285 Accumulation of GGpp in ER membranes triggers release of UBIAD1 from reductase,

286 rt that RNF145, a previously uncharacterized ER membrane ubiquitin ligase, participates in crosstalk

287 VAP interacts with secernin-1 (SCRN1) at the ER membrane via a single FFAT-like motif.

288 de evidence that ribosomes interact with the ER membrane via multiple modes and suggest regulatory me

289 Hsc70-SGTA-Hsp105 complex is tethered to the ER membrane, where Hsp105 and SGTA facilitate the extrac

290 R-luminal domain of CPXV012 inserts into the ER membrane, where it interacts with TAP.

291 age site form an extended alpha-helix in the ER membrane, which covers the cleavage site, thus preven

292 site is located at the cytosolic side of the ER membrane, which is a prerequisite for in trans cataly

293 stress initiated on the luminal side of the ER membrane, which may threaten its integrity.

294 ~60 amino acids are poorly inserted into the ER membrane, which suggests that translation is terminat

295 y, tombusviruses could also exploit expanded ER membranes, which provide enhanced subcellular environ

296 hanisms underlying stable interaction of the ER membrane with actin are unknown.

297 ated bridging, which dynamically anchors the ER membrane with actin filaments.

298 unknown proteins facilitate anchoring of the ER membrane with the cytoskeleton.

299 Treatment of ER membranes with myristic acid in the presence of cytos

300 TA) proteins into the endoplasmic reticulum (ER) membrane with an insertase (yeast Get1/Get2 or mamma