ライフサイエンスコーパス: ETEC

1 ETEC adheres to host epithelial cells in the small intes

2 ETEC adhesion is mediated by lectins (adhesins) that bin

3 ETEC are characterized by colonization factors (CFs) tha

4 ETEC causes disease by colonizing the small intestine an

5 ETEC have also been associated with important sequelae i

6 ETEC seedlings revealed increased photosynthesis and imp

7 ETEC strains expressing F4 fimbriae are associated with

8 ETEC strains that express the heat-stable toxin (ST), wi

9 ETEC was significantly associated with diarrhea (crude o

10 ETEC-associated diarrhea remains common among children l

11 ETEC-mediated diarrhea is orchestrated by heat-labile to

12 otype: 13 (14%) were DEC (10 EAEC, 2 EPEC, 1 ETEC) (12 associated with TD) and 39 (41%) ExPEC/UPEC (n

13 enetic characteristics of prophages from 132 ETEC isolates from symptomatic pigs to determine their p

14 different categories were identified in 132 ETEC strains; among these, 2.65% (32/1206) of ARGs were

15 as defined by the reference method was 1.2% ETEC, 0.1% Vibrio, 0% Y. enterocolitica, and 0% P. shige

16 Of the strains examined, 21 of 94 ETEC isolates lacked any previously identified CF.

17 related to EPEC, but appear to have acquired ETEC virulence genes.

18 ts showed that high pup survival rates after ETEC challenge were associated with suckling but not bir

19 vine colostral IgG (bIgG) antibodies against ETEC challenge in volunteers.

20 nisms by which intestinal antibodies against ETEC fimbriae function to prevent disease.

21 odies provide significant protection against ETEC expressing CS17.

22 ies conferred significant protection against ETEC, providing the first clinical evidence that fimbria

23 rotein in a subunit vaccine strategy against ETEC.

24 and fimbria-derived subunit vaccine against ETEC.

25 subunit and live-attenuated vaccines against ETEC and other enteric pathogens, including Shigella fle

26 ave been used in developing vaccines against ETEC diarrhea.

27 a heavy chain-only antibodies (VHHs) against ETEC to the Fc part of a porcine immunoglobulin (IgG or

28 ic regions were conserved exclusively in all ETEC genomes; however, we identified more genomic conten

29 ntified more genomic content conserved among ETEC genomes than among non-ETEC E. coli genomes, sugges

30 er evaluation of dsc(14)CfaE-sCTA2/LTB as an ETEC vaccine in humans.

31 combined with antigen/adjuvant toxoids as an ETEC vaccine.

32 This makes ST an attractive target for an ETEC vaccine.

33 One clone, derived from an ETEC 1766a genomic library (clone G10), did not produce

34 sites in the genome of H10407 (O78:H11), an ETEC strain that was originally isolated from the stool

35 Entamoeba histolytica, Cryptosporidium, and ETEC infections and more severe diarrhea.

36 Incidence of diarrhea and ETEC-associated diarrhea was 7.8 and 1.48 per child-year

37 trobacter rodentium, Salmonella enterica and ETEC were capable of complementing Aar activity by repre

38 A sequencing, demonstrated that the EPEC and ETEC virulence genes of these hybrid isolates were diffe

39 t contain virulence factors of both EPEC and ETEC.

40 association between H. pylori infection and ETEC diarrhea was similar, albeit not statistically sign

41 As a proof of principle, we designed anti-ETEC antibodies by fusing variable domains of llama heav

42 ed virulence factors or have the appropriate ETEC core genome required for virulence.

43 yl cyclase toxin-producing bacteria, such as ETEC.

44 model is an effective approach for assessing ETEC vaccine candidates, we used it to evaluate the abil

45 results imply that multivalent adhesin-based ETEC vaccines or prophylactics need more than one active

46 utination induced by class 5 fimbria-bearing ETEC.

47 in complex and dynamic interactions between ETEC and the gastrointestinal mucosae in which host glyc

48 were accompanied by visible changes in both ETEC architecture and the expression of surface antigens

49 ls in a 24 h period) in which either or both ETEC enterotoxins (LT and heat-stable toxin [ST]) were d

50 ying that each fimbrial type was acquired by ETEC strains very recently, consistent with a recent ori

51 nhibition of red blood cell agglutination by ETEC.

52 compound for treatment of diarrhea caused by ETEC and other adenylyl cyclase toxin-producing bacteria

53 otect travellers against diarrhoea caused by ETEC or other organisms.

54 ith the CFA/I and CS20 fimbriae expressed by ETEC strains.

55 The three fimbriae are expressed by ETEC, colonize in similar gut environments, and exhibit

56 cal characteristics of fimbriae expressed by ETEC.

57 fferences in host gene expression induced by ETEC infection.

58 , potentially, secretory outcomes induced by ETEC strains expressing LT+ST compared with strains that

59 herence to host intestinal cells mediated by ETEC fimbriae is believed to be a critical first step in

60 host interactions are finely orchestrated by ETEC and are characterized by coordinated responses invo

61 identified a number of molecules produced by ETEC that contribute to its virulence and are novel anti

62 On day 3, subjects ingested 5 x 109 cfu ETEC strain LSN03-016011/A in buffer.

63 Characterising ETEC and shigella subnational estimates of indirect morb

64 y and temporally diverse set of 192 clinical ETEC strains and identified 12 novel LT variants.

65 aracterized in ETEC at least 30% of clinical ETEC isolates lack known CFs.

66 ETAC), or elevated temperature/elevated CO2 (ETEC).

67 in EHEC O157:H7 and enterotoxigenic E. coli (ETEC) O139 and O149.

68 HLT encoded from an enterotoxigenic E. coli (ETEC) strain isolated from an avian host.

69 o sequenced a human enterotoxigenic E. coli (ETEC) strain of the same ST23 serogroup O78 lineage.

70 richia coli (EAEC), enterotoxigenic E. coli (ETEC), enteropathogenic E. coli (EPEC), Shigella spp., C

71 E. coli (EPEC) and enterotoxigenic E. coli (ETEC).

72 (n = 66), enterotoxigenic Escherichia coli (ETEC) (n = 31) or negative for bacterial pathogens (n =

73 (LT) from enterotoxigenic Escherichia coli (ETEC) and cholera toxin (CT) from Vibrio cholerae.

74 Enterotoxigenic Escherichia coli (ETEC) and shigella are two major pathogens that cause mo

75 butable to enterotoxigenic Escherichia coli (ETEC) and shigella infection in children younger than 5

76 Enterotoxigenic Escherichia coli (ETEC) are a major cause of diarrhea worldwide, and infec

77 The enterotoxigenic Escherichia coli (ETEC) are among the most common causes of diarrheal illn

78 es against enterotoxigenic Escherichia coli (ETEC) are being developed, many of which target common f

79 Enterotoxigenic Escherichia coli (ETEC) cause acute secretory diarrhoea in pigs, posing a

80 Enterotoxigenic Escherichia coli (ETEC) cause more than 500,000 deaths each year in the de

81 Enterotoxigenic Escherichia coli (ETEC) causes approximately 20% of the acute infectious d

82 Enterotoxigenic Escherichia coli (ETEC) causes considerable morbidity and mortality due to

83 Enterotoxigenic Escherichia coli (ETEC) causes diarrheal disease and significant morbidity

84 Enterotoxigenic Escherichia coli (ETEC) commonly cause diarrhea in children living in deve

85 Enterotoxigenic Escherichia coli (ETEC) commonly elaborate colonization factors comprising

86 imbriae of enterotoxigenic Escherichia coli (ETEC) comprise eight serologically discrete colonization

87 Porcine enterotoxigenic Escherichia coli (ETEC) continues to result in major morbidity and mortali

88 proximates enterotoxigenic Escherichia coli (ETEC) disease in humans is critical for the development

89 Enterotoxigenic Escherichia coli (ETEC) has consistently been the predominant bacterial ca

90 enges with enterotoxigenic Escherichia coli (ETEC) have broadened our understanding of this important

91 Enterotoxigenic Escherichia coli (ETEC) is a bacterial pathogen that causes diarrhea in ch

92 Enterotoxigenic Escherichia coli (ETEC) is a globally prevalent cause of diarrhea.

93 Enterotoxigenic Escherichia coli (ETEC) is a Gram-negative enteric pathogen that causes pr

94 Globally, enterotoxigenic Escherichia coli (ETEC) is a leading cause of childhood and travelers' dia

95 Enterotoxigenic Escherichia coli (ETEC) is a leading cause of death due to diarrheal illne

96 Enterotoxigenic Escherichia coli (ETEC) is a leading diarrheagenic bacterial pathogen amon

97 Enterotoxigenic Escherichia coli (ETEC) is a major cause of diarrheal illness in children

98 Enterotoxigenic Escherichia coli (ETEC) is a major cause of infectious diarrhea in childre

99 Enterotoxigenic Escherichia coli (ETEC) is a major cause of morbidity and mortality due to

100 Enterotoxigenic Escherichia coli (ETEC) is a major cause of travellers' diarrhoea.

101 Enterotoxigenic Escherichia coli (ETEC) is a significant cause of diarrheal disease and de

102 Enterotoxigenic Escherichia coli (ETEC) is a significant cause of morbidity and mortality

103 Enterotoxigenic Escherichia coli (ETEC) is an important pathogenic variant (pathovar) of E

104 Enterotoxigenic Escherichia coli (ETEC) is commonly associated with diarrhea in Egyptian c

105 Enterotoxigenic Escherichia coli (ETEC) is the leading cause of traveler's diarrhea and ch

106 f clinical enterotoxigenic Escherichia coli (ETEC) isolates, is comprised of two major subunit protei

107 Enterotoxigenic Escherichia coli (ETEC) produces both heat-labile (LT) and heat-stable (ST

108 Enterotoxigenic Escherichia coli (ETEC) produces the ADP-ribosyltransferase toxin known as

109 Enterotoxigenic Escherichia coli (ETEC) strains are a leading cause of morbidity and morta

110 Enterotoxigenic Escherichia coli (ETEC) strains are a major cause of diarrheal disease in

111 Enterotoxigenic Escherichia coli (ETEC) strains are among the most common causes of diarrh

112 Enterotoxigenic Escherichia coli (ETEC) strains are important causes of intestinal disease

113 ential for enterotoxigenic Escherichia coli (ETEC) to cause diarrhea.

114 develop an enterotoxigenic Escherichia coli (ETEC) vaccine have focused on the antigenically conserve

115 Enterotoxigenic Escherichia coli (ETEC), a leading cause of acute diarrhea, colonizes the

116 Enterotoxigenic Escherichia coli (ETEC), a major cause of infectious diarrhea, produce hea

117 accine for enterotoxigenic Escherichia coli (ETEC), an important cause of diarrheal illness.

118 olerae O1, enterotoxigenic Escherichia coli (ETEC), enteropathogenic E. coli, Campylobacter jejuni, a

119 r included enterotoxigenic Escherichia coli (ETEC), enteropathogenic E.coli (EPEC), Listeria monocyto

120 including enterotoxigenic Escherichia coli (ETEC), produce one or more serine proteases that are sec

121 es against enterotoxigenic Escherichia coli (ETEC), the most common bacteria causing diarrhea in chil

122 ocolitica, enterotoxigenic Escherichia coli (ETEC), Vibrio, and Plesiomonas shigelloides The study in

123 Enterotoxigenic Escherichia coli (ETEC)-caused postweaning diarrhea in piglets is one such

124 virus, and enterotoxigenic Escherichia coli (ETEC).

125 tor CS5 in enterotoxigenic Escherichia coli (ETEC).

126 nic E. coli [EPEC], enterotoxigenic E. coli [ETEC], enteroinvasive E. coli, and Shiga toxin-producing

127 ive E. coli [EAEC], enterotoxigenic E. coli [ETEC], enteropathogenic E. coli [EPEC], and Shiga-toxige

128 ella spp., enterotoxigenic Escherichia coli [ETEC], Shiga toxin-producing E. coli [STEC], E. coli O15

129 Enterotoxigenic Escherichia coli(ETEC) is an important cause of diarrheal disease and dea

130 onpermeabilized bacteria, while, conversely, ETEC 1766a seems to secrete most of the produced autotra

131 briae and suggest suitability of the LT|CS17-ETEC challenge model for interventional trials.

132 ered the expression of 61 genes in CS5 + CS6 ETEC isolates.

133 Our results indicate that CS5 + CS6 ETEC use NaGCH present in the small intestine as a signa

134 tes represent distinct and globally dominant ETEC clonal groups.

135 (24.2%), most commonly involving EPEC, EAEC, ETEC, and STEC.

136 vided long-awaited information for effective ETEC vaccine development.

137 Enterotoxigenic (ETEC) Escherichia coli (E. coli) causes traveller's diar

138 i O148 is a nonencapsulated enterotoxigenic (ETEC) Gram negative bacterium that can cause diarrhea, h

139 nia spp., Citrobacter spp., enterotoxigenic (ETEC) and enteroaggregative E. coli (EAEC), and members

140 ulture methods detected Shigella spp., EPEC, ETEC, and EAEC in smaller proportions of the samples tha

141 a following challenge with a CS17-expressing ETEC strain.

142 itial exposure, only ST and LT/ST-expressing ETEC isolates (P < 0.0001) were associated with disease

143 Among its virulence factors, ETEC produces heat-labile enterotoxin (LT).

144 The expanded effects of non-fatal ETEC and shigella-related diarrhoeal episodes can have l

145 dress this, we sequenced the genomes of five ETEC isolates obtained from children in Guinea-Bissau wi

146 for all specimens combined were as follows: ETEC, 97.6% (87.4 to 99.6), 99.8% (99.5 to 99.9), and 0.

147 ting resulted in increases of 24% (8-34; for ETEC) and 28% (10-39; for shigella) over direct deaths d

148 li O157:H7; 95% for Giardia lamblia; 94% for ETEC and STEC; 93% for Shigella spp.; 92% for Salmonella

149 ith alternate PCR and sequencing, except for ETEC, for which the reference method was two alternate P

150 l molecular signaling events responsible for ETEC-induced diarrhea, including cyclic GMP (cGMP) produ

151 five E. coli-like colonies were screened for ETEC enterotoxins using a GM1 enzyme-linked immunosorben

152 he availability of genomic DNA sequences for ETEC strains coupled with proteomics technology affords

153 The adhesion of four ETEC strains (E. coli H10407, CFA(+), K99 and K88) to PS

154 protein (LTBentero) containing epitopes from ETEC, S. typhimurium, and V. parahaemolyticus was produc

155 ies have focused on soluble LT purified from ETEC periplasm.

156 subunit (LTB) that reduce its secretion from ETEC without global effects on the toxin.

157 in addition to the two previously generated ETEC genomes, highlights the genomic diversity of ETEC.

158 attack rate of 80% with 10(11) CFU of H10407 ETEC.

159 In conclusion, we have shown the H10407 ETEC challenge of A. nancymaae to be an effective, repro

160 cratic Republic of the Congo had the highest ETEC-associated and shigella-associated mortality and st

161 for developing toxoid vaccines against human ETEC diarrhea.

162 were generally distinct from existing human ETEC database isolates.

163 10(11) CFU of the human pathogenic CFA/I(+) ETEC strain H10407 and examined for evidence of diarrhea

164 ral challenge with CFA/I-positive (CFA/I(+)) ETEC strain H10407 in the Aotus nancymaae nonhuman prima

165 rming units of colonization factor I (CFA/I)-ETEC strain H10407 with buffer.

166 For CFA/I-ETEC strain H10407, which has been extensively studied i

167 SR) analysis was further applied to identify ETEC-specific genomic regions when compared to non-ETEC

168 against the passenger domain of EatA impair ETEC delivery of labile toxin to epithelial cells sugges

169 A range of fimbrial adhesins in ETEC strains determines host and tissue tropism.

170 A central challenge in ETEC vaccinology has been the identification of conserve

171 cted promoters were used to study changes in ETEC transcriptomes.

172 s) have been identified and characterized in ETEC at least 30% of clinical ETEC isolates lack known C

173 ch also secretes LT, are highly conserved in ETEC and exist in other enteric pathogens, including oth

174 ile toxin (LT) are virulence determinants in ETEC diarrhea.

175 ion of virulence and colonization factors in ETEC.

176 an autotransporter previously identified in ETEC, possesses a functional serine protease motif withi

177 xpressed and secreted at wild-type levels in ETEC.

178 ave examined specific regulatory networks in ETEC, although little is known about the global effects

179 e is believed to be a critical first step in ETEC pathogenesis.

180 Inclusion of indirect ETEC and shigella mortality in burden estimates resulted

181 An isogenic ETEC 1766a strain with a tleA mutation showed an adhesio

182 Isolated ETEC expresses a plethora of colonization factors (fimbr

183 coverage) and that is called TleA (Tsh-like ETEC autotransporter) herein.

184 1 allele variants were correlated with major ETEC lineages expressing CS1 + CS3 or CS2 + CS3, and the

185 2 allele variants were correlated with major ETEC lineages expressing CS5 + CS6 or CFA/I.

186 Although this protein is expressed by many ETEC strains and is highly immunogenic, its precise func

187 ericidal, upregulates the expression of many ETEC virulence factors, including heat-stable (estA) and

188 urface antigen 20 (CS20) fimbriae as a model ETEC colonization factor, we show using force spectrosco

189 We modelled ETEC-related and shigella-related mortality and the effe

190 e greatest subnational heterogeneity in most ETEC and shigella mortality measures.

191 ctive antigen, using a lethal neonatal mouse ETEC challenge model and passive dam vaccination.

192 escent human sera obtained following natural ETEC infections demonstrated multiple immunoreactive mol

193 conserved among ETEC genomes than among non-ETEC E. coli genomes, suggesting that ETEC isolates shar

194 pecific genomic regions when compared to non-ETEC genomes, as well as genes that are more associated

195 CS20 fimbriae impedes sustained adhesion of ETEC to the intestinal mucosal surface.

196 Particularly, passive oral administration of ETEC anti-fimbrial antibodies prevent ETEC diarrhea.

197 th of toxin-induced cAMP accumulation and of ETEC adherence to epithelial cells.

198 sequencing of a representative collection of ETEC isolated between 1980 and 2011 identified globally

199 e that influences intestinal colonization of ETEC by degrading the major mucins in the small intestin

200 le is known about the genomic composition of ETEC.

201 he conventional methods for the detection of ETEC, Vibrio, Y. enterocolitica, and P. shigelloides in

202 The distribution of ETEC enterotoxins varied between the symptomatic childre

203 genomes, highlights the genomic diversity of ETEC.

204 Many elements of ETEC pathogenesis are still poorly defined.

205 The epidemiology of ETEC diarrhea among children living in a rural Egyptian

206 ate 196 million (95% UI 135-269) episodes of ETEC and shigella diarrhoea occur annually, resulting in

207 tness have persisted during the evolution of ETEC and have spread globally.

208 ation between initial or repeat excretion of ETEC and the occurrences of diarrhea.

209 seq), was used to quantify the expression of ETEC virulence and colonization factors.

210 The key virulence factors of ETEC strains, their serotypes, and their fimbrial compon

211 attributed to this biomechanical feature of ETEC fimbriae.

212 ANR homologs of ETEC and Vibrio cholerae bound to AggR as well as to oth

213 Incidence of ETEC infection was estimated among children with diarrhe

214 The majority of ETEC strains produce both ST and LT.

215 ae to be an effective, reproducible model of ETEC disease, and importantly, we have demonstrated that

216 , we found that a major effector molecule of ETEC, the heat-labile enterotoxin (LT), may enhance thes

217 in gene expression and surface morphology of ETEC upon interaction with intestinal epithelial cells i

218 nisation with a patch containing 37.5 mug of ETEC LT or a placebo patch.

219 itional insight into the intricate nature of ETEC interactions with the intestinal epithelium that ha

220 a paradigm for the molecular pathogenesis of ETEC in which the bacteria use toxin to drive up-regulat

221 dies establish the relative pathogenicity of ETEC expressing newer class 5 fimbriae and suggest suita

222 We evaluated the pathogenicity of ETEC isolates in a birth cohort of children living in a

223 The pathogenicity of ETEC was estimated in symptomatic children compared to t

224 es of a geographically diverse population of ETEC elaborating CFA/I (n = 31), CS17 (n = 20), and CS2

225 ard reaction may serve in the prophylaxis of ETEC K88 diarrhoea.

226 , an immunogenic secreted serine protease of ETEC, contributes to virulence by degrading MUC2, the ma

227 PCR screening of ETEC isolates revealed that 8.6% (n = 13) of "CF negativ

228 A study of ETEC isolates from humans in Brazil reported the existen

229 imera comprised of a pentameric B subunit of ETEC heat-labile toxin (LTB) in lieu of the CTB pentamer

230 EtpA interacts with the tips of ETEC flagella to promote bacterial adhesion, toxin deliv

231 ector EspB of EPEC, and heat-labile toxin of ETEC were secreted.

232 These studies increase our understanding of ETEC evolution, as well as provide insight into virulenc

233 d pili, including the CFA/I pili, present on ETEC and other Gram-negative bacterial pathogens.

234 Pig ETEC strain was unable to ferment galactooligosaccharide

235 hylogenetic distribution of clinical porcine ETEC strains and their plasmid-associated genetic conten

236 Overall, most porcine ETEC strains appear to have emerged from a limited subse

237 ea revealed that a limited subset of porcine ETEC lineages exist that generally contain common toxin

238 The genomes of porcine ETEC strains UMNK88 and UMNF18 were both found to contai

239 r of animal pathogens (eg, bovine or porcine ETEC) that do not cause human illness.

240 ces of K88-positive and F18-positive porcine ETEC strains and examined the phylogenetic distribution

241 ion of ETEC anti-fimbrial antibodies prevent ETEC diarrhea.

242 erstanding, tracking and possibly preventing ETEC disease.

243 livery of the heat-labile toxin, a principal ETEC virulence determinant.

244 However, as LT also promotes ETEC adhesion to intestinal epithelial cells, we postula

245 transcription factor csvR, and the putative ETEC virulence factor cexE.

246 in scores of enteroid lumens, recapitulating ETEC-induced intestinal secretion.

247 enterotoxins and pathogenicity during repeat ETEC infections appears to be variable and dependent on

248 e breast-feeding was protective for repeated ETEC infection.

249 High risk of repeated ETEC diarrhea was associated with being over 6 months of

250 astrovirus, norovirus, Shigella, Salmonella, ETEC, sapovirus, and typical EPEC.

251 Here we demonstrate that YghJ, a secreted ETEC antigen identified in immunoproteomic studies using

252 unction blocked the activity of the secreted ETEC factor, suggesting that this yet-uncharacterized ac

253 lonization factor genes across all sequenced ETEC genomes not only identified variability but also in

254 in the placebo group had moderate or severe ETEC diarrhoea (vaccine efficacy 34.6%, -2.2 to 58.9; p=

255 higella spp, rotavirus, adenovirus 40/41, ST-ETEC, Cryptosporidium spp, and Campylobacter spp.

256 eat-stable enterotoxin-producing E coli ([ST-ETEC] around 1.5 times).

257 Norovirus GII, Cryptosporidium, Shigella, ST-ETEC, and adenovirus 40/41 were also important.

258 ting five pathogens (rotavirus, Shigella, ST-ETEC, Cryptosporidium, typical enteropathogenic E coli)

259 erichia coli producing heat-stable toxin (ST-ETEC; with or without co-expression of heat-labile enter

260 ed with increased risk of case death were ST-ETEC (hazard ratio [HR] 1.9; 0.99-3.5) and typical enter

261 ains were more closely related to human ST23 ETEC than to APEC O1, indicating that separation of path

262 A sustained ETEC infection, under adverse conditions of dynamic shea

263 It has long been known that ETEC heat-labile toxin (LT) activates production of cAMP

264 Here we report that ETEC secretes a heat-stable, proteinaceous factor that b

265 Indeed, here we show that ETEC use LT to up-regulate carcinoembryonic antigenrelat

266 These data suggest that ETEC evades the host innate immune response by directly

267 Emerging data suggest that ETEC undergoes considerable changes in its surface archi

268 ng non-ETEC E. coli genomes, suggesting that ETEC isolates share a genomic core.

269 The ETEC strain 1766a, obtained from a child with watery dia

270 In contrast, the ETEC colonization factors CS1 and CS3 were downregulated

271 lusion, naturally occurring mutations in the ETEC adhesive and non-adhesive subunits altered function

272 The eight related members of the ETEC class 5 fimbrial family are subdivided into three s

273 In corroboration, preincubation of the ETEC inoculum with antiadhesin and antifimbrial bovine c

274 genome" confirmed the diverse history of the ETEC pathovar and provides a finer resolution of the E.

275 toxin would have a suppressive effect on the ETEC colonization capabilities.

276 noprecipitation experiments suggest that the ETEC factor functions by preventing IkappaBalpha polyubi

277 ponses corroborating reduced exposure to the ETEC pathogen, and a significantly higher weight gain co

278 ted that some antigens are restricted to the ETEC pathovar.

279 on showed that prophages correlated with the ETEC lineage distribution, and further identification of

280 partner adhesin that is conserved within the ETEC pathovar.

281 a useful complement to ongoing approaches to ETEC vaccine development.

282 nd at least one of these episodes was due to ETEC.

283 al disease as well as the sequelae linked to ETEC are still evolving.

284 al function may provide insights relevant to ETEC vaccine development.

285 us nancymaae, a New World monkey species, to ETEC infection.

286 re stunting and 44 400 (29 400-59 800) total ETEC deaths and 63 100 (44 000-81 900) total shigella de

287 mates resulted in a 20-30% increase in total ETEC and shigella mortality rates in some subnational ar

288 dentify novel compounds to prevent and treat ETEC diarrheal disease.

289 enged 30 healthy adults with an unattenuated ETEC strain, and collected serial blood samples shortly

290 ic analyses of 94 previously uncharacterized ETEC isolates demonstrated remarkable genomic diversity,

291 ave important implications for understanding ETEC pathogenesis, unraveling immunologic responses indu

292 n, 31 volunteers received product, underwent ETEC challenge, and were included in the per protocol ef

293 dings from the first challenge studies using ETEC-expressing colonization factor fimbria CS17 and CS1

294 ve" LT + STp isolates and is associated with ETEC that cause diarrhea.

295 Pretreating intestinal epithelial cells with ETEC supernatant significantly blocked the degradation o

296 host response to experimental challenge with ETEC.

297 oral prophylaxis and 35 were challenged with ETEC.

298 relevant chemical signals were combined with ETEC isolate E24377A during growth in either Luria broth

299 roteomics approach to antigen discovery with ETEC strain H10407.

300 protective against intestinal infection with ETEC.