ライフサイエンスコーパス: Env glycoprotein

1 ions exhibiting unique patterns of processed Env glycoprotein.

2 IV-2 isolates, where it is controlled by the Env glycoprotein.

3 with protein and glycan features of the HIV Env glycoprotein.

4 levels as well as fusogenic activity of the Env glycoprotein.

5 lls mediated by cell surface-expressed HIV-1 Env glycoprotein.

6 bodies reactive with xenotropic or MCF virus env glycoproteins.

7 ASBP-M(4070A) forms particles containing MLV Env glycoproteins.

8 inactivation of sensitive but not resistant Env glycoproteins.

9 r stomatitis virus, or murine leukemia virus Env glycoproteins.

10 ency virus it is a property of the envelope (Env) glycoprotein.

11 or immune recognition of the HIV-1 envelope (Env) glycoprotein.

12 n by expressing a SER5-insensitive envelope (Env) glycoprotein.

13 ease-causing agents, such as HIV-1 envelope (Env) glycoprotein.

14 unodeficiency virus type 1 (HIV-1) envelope (Env) glycoprotein.

15 iciency virus type 1 (HIV-1) gp120 envelope (Env) glycoprotein.

16 ls of genetic diversity in the HIV envelope (Env) glycoprotein.

17 udding even in the presence of the envelope (Env) glycoproteins.

18 ent preparations of oligomeric SIV envelope (Env) glycoproteins.

19 ytoplasmic domains of the relevant envelope (Env) glycoproteins.

20 y and phenotypically diverse SIVsm envelope (Env) glycoproteins.

21 PIV1 from a chimpanzee for the pol, gag, and env glycoprotein 120 (gp120) regions, indicating greater

22 d the binding of ADCC-mediating mAb to HIV-1 Env glycoprotein 120 (gp120).

23 ion deletion of the C-terminal tail of HIV-1 Env glycoprotein 41 (gp41) showed reduced sensitivity to

24 man immunodeficiency virus (HIV-1) envelope (Env) glycoprotein, a (gp120-gp41)(3) trimer, mediates fu

25 The HIV-1 envelope (Env) glycoprotein, a trimer of gp120-gp41 heterodimers,

26 HIV-1-infected cells to ADCC by opening the Env glycoprotein and exposing CD4-induced (CD4i) epitope

27 Structural features of the Env glycoprotein and its enormous variability have frust

28 e the human immunodeficiency virus envelope (Env) glycoprotein and intracellular fusion machines, are

29 in the incorporation of the viral envelope (Env) glycoproteins and can influence particle infectivit

30 ld-type levels of the Gag cleavage products, Env glycoproteins, and reverse transcriptase activity wh

31 c antibody responses against HIV-1 envelope (Env) glycoproteins, and little is known about how the ra

32 luble oligomeric form of an avian retroviral Env glycoprotein (API) and soluble forms of its receptor

33 se released virus particles unable to obtain Env glycoproteins are non-infectious and unable to propa

34 The Env glycoproteins are synthesized as a polyprotein precu

35 Compact, glycan-restricted envelope (Env) glycoproteins are selected during heterosexual tran

36 The HIV-1 envelope (Env) glycoprotein binds to host cell receptors to mediat

37 ector priming followed by purified envelope (Env) glycoprotein boosting.

38 tance genes Fv4 and Rmcf in that it produces Env glycoprotein but fails to produce infectious virus;

39 le HIV-1 pseudotyped with an HIV-1 envelope (Env) glycoprotein, but not with vesicular stomatitis vir

40 ring of soluble mimetics of the trimeric HIV Env glycoprotein (commonly termed gp140 immunogens).

41 However, the mechanism by which the Env glycoprotein complex is incorporated into virus part

42 al production of a clinical HIV vaccine with Env glycoprotein components.IMPORTANCE HIV-1 Env protein

43 s immunized with recombinant HIV-1 envelope (Env) glycoprotein constructs.

44 osting with a recombinant trimeric envelope (Env) glycoprotein delivered in MF59 adjuvant.

45 IV-1 and simian immunodeficiency virus (SIV) Env glycoproteins, despite no HIV/SIV-related proteins b

46 transmembrane proteins in addition to viral Env glycoprotein during assembly at the plasma membrane.

47 ructurally defined mimics of native trimeric Env glycoproteins (e.g., SOSIP trimers) present multiple

48 HIV-1 Env glycoprotein (Env) immunogenicity is limited in part

49 biased lambda light chain use during the HIV Env glycoprotein (Env) response in HIV infection and vac

50 The V3 loop of the ENV glycoprotein exerts a dominant influence on the inte

51 se in mice that is largely mediated by viral Env glycoprotein expression within central nervous syste

52 The HIV-1 Envelope (Env) glycoprotein facilitates host cell fusion through a

53 erties that target six epitopes of the HIV-1 Env glycoprotein for their ability to inhibit viruses th

54 and the filovirus Ebola use their envelope (Env) glycoproteins for this purpose.

55 construct can restrict the incorporation of Env glycoproteins from an evolutionarily distant HIV-1 p

56 xpressing clade B Gag-Pol fusion protein and Env glycoproteins from clades A, B, and C) was administe

57 brane-spanning domain (MSD) of the envelope (Env) glycoprotein from human (HIV) and simian immunodefi

58 Envelope (Env) glycoproteins from different HIV-1 isolates exhibit

59 ities of 48 donor and 25 recipient envelope (Env) glycoproteins from five subtype C heterosexual tran

60 deficiency viruses (SHIVs) bearing envelope (Env) glycoproteins from primary HIV-1 strains fail to in

61 attachment and entry properties of envelope (Env) glycoproteins from T/F and chronic control (CC) vir

62 Biologically functional clade C envelope (Env) glycoproteins from the chronically (donor) and newl

63 and highlight the ability of MA to influence Env glycoprotein function.

64 referentially bind the HIV (HIV-1) envelope (Env) glycoprotein (gp) trimer and broadly neutralize the

65 INC5 is determined by sequences in the viral Env glycoprotein gp120, and the antiviral effect of SERI

66 d many recognize novel epitopes on envelope (Env) glycoprotein gp120, illuminating new targets for va

67 tibodies (bNAbs) against the viral envelope (Env) glycoproteins gp120 and gp41, but no immunogen has

68 r NYVAC vectors alone or in combination with Env glycoprotein (gp120) followed by a co-delivered NYVA

69 an immunodeficiency type 1 (HIV-1) envelope (Env) glycoprotein (gp120) to CD4 triggers the induction

70 0.002) in the V1 to V4 region of the surface Env glycoprotein, gp120, compared to the B cohort.

71 NCE The incorporation of the HIV-1 envelope (Env) glycoproteins, gp120 and gp41, into virus particles

72 Because HIV-1 Env glycoprotein has been implicated in bystander apopto

73 of risk, such as vaccine-elicited anti-HIV-1 Env glycoprotein IgG3 antibodies and antibody-dependent

74 We recently reported that an Env glycoprotein immunogen (o-gp140SF162DeltaV2) contain

75 smid-based and recombinant protein envelope (Env) glycoprotein immunogens were derived from a primary

76 activities against conserved epitopes of the env glycoprotein in cultures induced with the AV3 mutant

77 sulted in the stable secretion of a trimeric Env glycoprotein in mammalian cell cultures.

78 tail of gp41 and the matrix domain of Gag in Env glycoprotein incorporation.

79 For murine leukemia virus envelope (MLV Env) glycoprotein, incorporation into foreign viral part

80 For murine leukemia virus envelope (MLV Env) glycoprotein, incorporation into foreign viral part

81 late immune responses to the HIV-1 envelope (Env) glycoprotein induced by DNA vaccination.

82 get cells is mediated by the HIV-1 envelope (Env) glycoprotein interacting with host receptor CD4, wh

83 in this domain disrupt the incorporation of Env glycoproteins into virions and markedly impair virus

84 ing the incorporation of the viral envelope (Env) glycoprotein into virions.

85 The incorporation of viral envelope (Env) glycoproteins into nascent particles is an essentia

86 eting of Gag, the incorporation of envelope (Env) glycoproteins into nascent particles, and the nucle

87 The incorporation of envelope (Env) glycoproteins into virions is an essential step in

88 n of the human immunodeficiency virus type 1 Env glycoprotein is important for endocytosis from the p

89 The gp120 subunit of the HIV Env glycoprotein is responsible for receptor interaction

90 Although processing of the Env glycoproteins is not changed, proteasome inhibitors

91 Incorporation of the viral envelope (Env) glycoprotein is a critical requirement for the prod

92 unodeficiency virus type 1 (HIV-1) envelope (Env) glycoprotein is oligomeric, with the major points o

93 unodeficiency virus type 1 (HIV-1) envelope (Env) glycoprotein is oligomeric.

94 he high-mannose patch on the HIV-1 envelope (Env) glycoprotein is the epicenter for binding of the po

95 The envelope (Env) glycoprotein is the main focus of HIV-1 vaccine dev

96 The viral envelope (Env) glycoprotein is then recruited to the assembly site

97 n immunodeficiency virus type 1 (HIV-1) gp41 Env glycoprotein, is a potent inhibitor of virus infecti

98 Wild-type Env glycoproteins lack detectable affinity for supersite

99 mation by selectively inactivating sensitive Env glycoproteins, likely through altering their conform

100 natural polymorphism in the HIV-1 envelope (Env) glycoprotein, lysine at position 425 was selected a

101 e env segments, that distinct regions of the Env glycoprotein may be important for utilization of dif

102 Consequently, the Env glycoprotein-mediated fusion function constitutes an

103 HIV-1 Env glycoprotein-mediated fusion is initiated upon seque

104 lymphotropic virus type 1 (HTLV-1) envelope (Env) glycoprotein mediates binding of the virus to its r

105 man immunodeficiency virus (HIV-1) envelope (Env) glycoprotein mediates viral entry and is the sole t

106 The HIV-1 envelope (Env) glycoprotein mediates viral entry during both cell-

107 has been associated with expression of viral Env glycoprotein; Northern blotting with specific hybrid

108 ane subunit (TM), the fusion subunit, of the Env glycoprotein of the subtype A avian sarcoma and leuk

109 lizable strategy for constructing SHIVs with Env glycoproteins of interest, including those that in h

110 The envelope (Env) glycoprotein of HIV is an important determinant of

111 The envelope (Env) glycoprotein of HIV is expressed on the surface of

112 The envelope (Env) glycoprotein of HIV is the only intact viral protei

113 The envelope (Env) glycoprotein of human immunodeficiency virus (HIV)

114 The envelope (Env) glycoprotein of human immunodeficiency virus type 1

115 The envelope (env) glycoprotein of human immunodeficiency virus type 1

116 Envelope (Env) glycoprotein of human immunodeficiency virus type 1

117 Interestingly, the envelope (Env) glycoprotein of this clade B virus had a rare GPEK

118 The envelope (Env) glycoproteins of both viruses can transform rodent

119 omains of the strikingly conserved envelope (Env) glycoproteins of bovine leukemia virus (BLV) and it

120 Recombinant HIV-1 envelope (Env) glycoproteins of ever-increasing sophistication hav

121 ic Env proteins do not resemble the trimeric Env glycoprotein on HIV-1 viruses, which has implication

122 generation of a library of Cys mutations in Env glycoprotein on the viral surface, covalent labeling

123 The envelope (Env) glycoproteins on HIV-1 virions are the sole target

124 The envelope (Env) glycoproteins on these HIV-1 variants expose a core

125 The role of virus replication, Env glycoprotein phenotype, and immune activation (IA) i

126 The HIV-1 envelope (Env) glycoproteins play an essential role in the virus r

127 unodeficiency virus type 1 (HIV-1) envelope (Env) glycoprotein poses a major challenge for the develo

128 man immunodeficiency virus (HIV-1) envelope (Env) glycoprotein precursor (gp160) trimerizes, is modif

129 bodies (nnAbs) specific to the HIV envelope (Env) glycoproteins present at the surface of virus sensi

130 ibody (NAb) response against viral envelope (Env) glycoproteins present during acute and early infect

131 The HIV-1 Env glycoprotein presents a dense patchwork of host cell

132 on SIVMAC but expressing the HIV-1 envelope (Env) glycoproteins (SHIVs) remains the most powerful mod

133 Most neutralizing antibodies target the Env glycoprotein spikes found on the virus surface.

134 abling a more complete representation of the Env glycoprotein structure.

135 uman immunodeficiency virus type 1 envelope (Env) glycoprotein structure and function is based on stu

136 tly visualize trilobed presumptive envelope (env) glycoprotein structures on the surface of negativel

137 ions not in Gag but in Vpu and the envelope (Env) glycoprotein subunits gp120 and gp41.

138 tance genes control expression of xenotropic env glycoprotein that interferes with exogenous virus in

139 s have identified targets on HIV-1 envelope (Env) glycoprotein that are vulnerable to antibody neutra

140 onformational changes in the viral envelope (Env) glycoprotein that lead to membrane fusion.

141 Ps) bear nonnative "junk" forms of envelope (Env) glycoprotein that may undermine the development of

142 we review our current understanding of HIV-1 Env glycoprotein trafficking and incorporation into viri

143 Much is currently known about the HIV-1 Env glycoprotein trafficking pathway and the structure o

144 ration nickel-based liposomes captured HIV-1 Env glycoprotein trimers via a noncovalent linkage with

145 a recombinant vaccinia virus expressing 89.6 Env glycoprotein (vBD3) in a mouse challenge model, we o

146 Surprisingly, the +3L Env glycoprotein was able to produce infectious particle

147 owever, the stability of the cell-associated Env glycoprotein was decreased and Env incorporation int

148 Instead, the HIV-2 Env glycoprotein was found to antagonize BST-2 in some i

149 A retroviral vector that does not encode any Env glycoprotein was packaged into retroviral particles

150 In contrast, the RSV Env glycoprotein was robustly recruited only to the homo

151 Twenty HIV-1 Env glycoproteins were examined for their ability to bin

152 Interestingly, AIP of HIV-1 Env glycoproteins were found to correlate inversely with

153 aCFI(HXB2/89.6) vector expressing a modified Env glycoprotein with C-terminal mutations intended to m

154 s dispensable for the incorporation of HIV-1 Env glycoproteins with a shortened cytoplasmic domain.

155 mmunodeficiency virus type 1 (HIV-1), encode Env glycoproteins with unusually long cytoplasmic tails,

156 ncluding HIV-1, have transmembrane envelope (Env) glycoproteins with cytoplasmic tails that are quite

157 with murine leukemia virus (MuLV) envelope (Env) glycoproteins without affecting infectivity conferr