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1 IV-1 particles bearing the SERINC5-resistant Env protein.
2 ved Gag and the cytoplasmic tail (CT) of the Env protein.
3 l proteins and a singly spliced mRNA encodes Env protein.
4 ous neutralization determinants on the HIV-1 Env protein.
5 d on the surface of the gp120 subunit of the Env protein.
6 icular stomatitis virus (VSV) expressing HIV Env protein.
7 ch region in the surface (SU) subunit of the Env protein.
8 binant expressing a secreted form of the HIV Env protein.
9 levels of antibody responses against the HIV Env protein.
10 boosted (week 8) with the DNA or recombinant Env protein.
11 he induction of XC cell syncytia by the R(+) Env protein.
12 lowed by two doses of NYVAC vector and gp120 Env protein.
13 usion-inducing conformational changes in the Env protein.
14 diversity and poor immunogenicity of the HIV Env protein.
15 rize the phenotypic features of the M-tropic Env protein.
16 ts a need for broad antibodies targeting the Env protein.
17 with about 500 glycoforms characterized per Env protein.
18 rains LAI and NL4.3 lack wild-type levels of Env proteins.
19 HERV-K(HML-2)] and the expression of Gag and Env proteins.
20 ents of HTLV-3 using independently expressed Env proteins.
21 uld confer this property on two heterologous Env proteins.
22 tness similar to those carrying the mothers' Env proteins.
23 tance mutations into phenotypically distinct Env proteins.
24 e leukemia virus (MLV), bearing heterologous Env proteins.
25 rotocol with their homologous vaccine native Env proteins.
26 endent virus, and with subgroups A or B ASLV Env proteins.
27 ls that were transformed by the JSRV or ENTV Env proteins.
28 ke particles (VLPs), both FV and HBV require Env proteins.
29 m by comparing tier 1 NL Env with tier 3 AD8 Env proteins.
30 ably, this entry block is dependent on viral Env proteins.
31 r the 17b antibody than are IFITM3-resistant Env proteins.
32 h MA facilitates the virion incorporation of Env proteins.
33 uences largely encoded intact and functional Env proteins.
34 ning technique of obtaining novel retargeted Env proteins.
35 properties have been described for subtype C Env proteins.
36 ) that are buried in the parental, unadapted Env proteins.
37 ons in the HR1 region of the viral envelope (Env) protein.
38 e V3 glycan supersite on the HIV-1 envelope (Env) protein.
39 he sequence of the capsid (CA) and envelope (Env) proteins.
41 -displayed human antibody library; these two Env proteins (89.6 and IIIB gp140s), and one additional
42 ccine will include a recombinant form of the Env protein, a trimer located on the virion surface.
44 bsets prior to immunization with recombinant Env protein affects the vaccine-induced Ab response in m
47 e show that expression of the JSRV envelope (Env) protein alone in lungs of mice, by using a replicat
48 IV vaccines have included purified envelope (Env) protein among the boosting components of the regime
49 anding of the humoral responses to the HIV-1 Env protein and provide insights regarding the most rele
51 ximately normal amounts of Gag, Gag-Pol, and Env proteins and genomic viral RNA (vRNA), but several m
52 ortant influences on the quality of trimeric Env proteins and hence their suitability as vaccine comp
53 tivated in cells transformed by JSRV or ENTV Env proteins and in cells transformed by the proteins wi
54 reflect different interactions between their Env proteins and molecules on CD4(+) and CD8(+) T cells
56 human immunodeficiency virus type 1 (HIV-1) Env proteins and possess broad neutralizing activities.
57 enome, in addition to the structural Gag and Env proteins and retroviral enzymes, carries a region at
58 protein alters the conformation of the HIV-1 Env proteins and that this action is correlated with SER
59 l conformational heterogeneity of some HIV-1 Env proteins and, by extrapolation, also vaccine immunog
60 led vaccine targets on the virus's envelope (Env) protein and are themselves promising immunotherapie
61 obe interactions between the viral envelope (Env) protein and CXCR4 and to identify pathways by which
62 ns within the V3 loop of the viral envelope (Env) protein and was modulated by additional mutations i
63 ined viral sequences in their DNA, expressed Env protein, and showed retroviral particles by electron
64 ular protein, Zfp111, that binds to the JSRV Env protein, and this binding plays a role in Env transf
65 lowed by two doses of NYVAC vector and gp120 Env protein; and T4 was two doses of DNA vector and gp12
66 ssing the human immunodeficiency virus (HIV) Env protein are nonpathogenic in mice, even when given b
69 These data suggest that VIR165-dependent Env proteins are kinetically trapped in the unliganded s
70 To increase yield and simplify purification, Env proteins are often made in truncated, soluble forms.
71 to SERINC5, whereas the majority of tier 2/3 Env proteins are resistant to SERINC5, when viruses are
74 r the further design and production of HIV-1 Env proteins as the critical components of HIV-1 vaccine
76 f trimer spokes have been observed to impair Env protein assembly into virus particles, and several o
77 to HIV-1 gp120, suppress interactions of the Env protein at host cell receptor binding sites, inhibit
78 recombinant expressing the membrane-anchored Env protein at producing CD8 T cells and antibody respon
79 nstrated to contain high levels of the viral env proteins, averaged 70-79 trimers per virion in tomog
82 yl lipid A and QS-21 (MPLA+QS-21)-adjuvanted Env protein boost (D(IP-10) P(ALFQ)) in macaques, we obs
83 ncept that a distally related retroviral SIV Env protein boost can increase pre-existing NAb response
84 v and monovalent gag) followed by a 5-valent Env protein boost for seronegative adults was previously
85 These data demonstrate that the adjuvanted Env protein boost is critical for protecting against hig
87 vs) DNA prime, followed by a SIVmac239 gp140 Env protein boost that aimed to focus the immune respons
89 of the alphavirus replicon vector prime plus Env protein boost vaccine approach for the induction of
96 e characteristics and immunogenicity of this Env protein, both alone and mixed together with a clade
98 g antibodies (nAbs) to some cloned SIVsmE660 Env proteins, but antibodies able to neutralize the chal
100 he murine leukemia virus (MLV) transmembrane Env protein by the viral protease in MLV Env-pseudotyped
101 man immunoglobulin G that reacted with HIV-1 Env proteins by enzyme-linked immunosorbent assay and ne
104 These results show that the JSRV and ENTV Env proteins can transform epithelial cells besides BEAS
105 s so they may not accurately represent HIV-1 Env proteins circulating in humans, potentially limiting
108 r proteins may influence surface exposure of Env protein complexes in virus-infected cells, assisting
110 n overlapping peptide pools from three HIV-1 Env proteins, CON6, MN (subtype B), and Chn19 (subtype C
112 NLHX; however, all of the PFI-insusceptible Env proteins conserved the sequence of a critical enfuvi
113 us type 1) uses its trimeric gp160 envelope (Env) protein consisting of non-covalently associated gp1
115 unodeficiency virus type 1 (HIV-1) envelope (Env) protein contains numerous N-linked carbohydrates th
116 Among HIV-1 gene products, the envelope (Env) protein contains variable as well as conserved regi
118 fected by ENTV vectors, even though the ENTV Env protein could bind well to human Hyal2 expressed on
119 humoral and cellular immune responses to the Env protein could reveal potential determinants of vacci
120 possibility that these endogenous retroviral Env proteins could directly influence HIV-1 replication.
123 the CD4-binding site of the HIV-1 envelope (Env) protein (denoted VRC01) was modified by site-direct
124 irus envelope (Env) have been conducted with Env proteins derived from clade B viruses isolated durin
125 en soluble gp140 and virion-associated gp160 Env proteins derived from SF162 may be the basis for the
126 tion sensitivities of HIV-1 pseudotyped with Env proteins derived from two prototypic clade B primary
127 ay measurable binding to a recombinant gp140 Env protein (derived from the dual-tropic 89.6 virus), w
128 protein in the boosting phase along with the Env protein did not contribute further to the preservati
129 The results demonstrated that ancestral Env proteins did not impart broad levels of protection a
130 rsions of CZA97.012 and 92UG037.8 oligomeric Env proteins do not resemble the trimeric Env glycoprote
132 0 and boosted with MPLA-plus-alum-adjuvanted Env protein (DP(ALFA)) The D(IP-10) P(ALFQ) vaccine regi
133 candidate HIV-1 vaccine vectors and purified Env proteins elicited potent and durable humoral immune
135 possessed long env open reading frames, the Env proteins encoded by these loci were nonfunctional ac
139 and T4 was two doses of DNA vector and gp120 Env protein followed by two doses of NYVAC vector and gp
140 ine leukemia virus retroviral Envelope (FeLV Env) protein for productive infection of feline AH927 ce
142 ne (expressing clade B Gag, Pol, and Nef and Env proteins from clades A, B, and C) was administered a
146 ggest that a multicomponent vaccine encoding Env proteins from multiple clades of HIV-1 can generate
150 n for their ability to incorporate envelope (Env) proteins from other retroviral strains and genera,
151 odies, soluble HIV-1 envelope glycoproteins (Envs proteins) from two isolates complexed with two-doma
152 However, recent structural studies of HIV-1 Env proteins, generation of novel bNAbs, maturation of t
156 ults indicate that the R peptide of the MuLV Env protein has a sequence-dependent inhibitory effect o
157 mmunodeficiency virus type 1 (HIV-1) surface Env protein has been implicated in the development of HI
158 mates (NHPs) were boosted with various SOSIP Env proteins; however, significant neutralization was no
161 cles in general and perhaps also for soluble Env proteins.IMPORTANCE Recombinant trimeric SOSIP prote
162 ble of lysing target cells expressing HERV-K env protein in BC patients but not in normal female cont
163 s were primed with VRP and then boosted with Env protein in MF59 adjuvant, or they were given VRP int
166 domain (CTD) of murine leukemia virus (MuLV) Env protein in viral fusion was indicated by the potent
168 d characterized viruses pseudotyped with the Env proteins in a single-round drug sensitivity assay.
170 the virus ensures the production of Gag and Env proteins in an appropriate ratio remains unknown.
172 between T cell-tropic and macrophage-tropic Env proteins, including functional differences with host
176 litates the incorporation of HIV-1 envelope (Env) proteins into virions by virtue of an interaction w
177 he human immunodeficiency virus type 1 gp120 Env protein is a key domain in Env due to its role in in
178 Env glycoprotein components.IMPORTANCE HIV-1 Env protein is a major target for the development of an
183 at the more promiscuous use of CCR5 by these Env proteins is selected against at the level of virus t
184 The gp120 subunit of the HIV-1 envelope (Env) protein is heavily glycosylated at approximately 25
185 human immunodeficiency virus (HIV) envelope (Env) protein is incorporated into HIV virions or virus-l
186 f the murine leukemia virus (MuLV) envelope (Env) protein is known to play an important role in regul
190 ported on a panel of HIV-1 clade B envelope (Env) proteins isolated from a patient treated with the C
193 essing JSRV Env caused a marked reduction in Env protein levels, indicating that human Hyal2 suppress
195 These results suggest that some engineered Env proteins may more efficiently direct responses towar
197 g antibodies directed at the HIV-1 envelope (Env) protein might block outgrowth of some reservoir vir
198 gths of the individual Env-receptor bonds of Env proteins obtained from a HIV-1 infected patient prio
199 ion of immune escape variants.IMPORTANCE The Env protein of HIV is highly glycosylated, and the sites
204 ically evaluated the differences between the Env proteins of simian immunodeficiency virus/simian HIV
205 characteristics of the binding of V3 MAbs to Env proteins of the subtype B virus JR-FL and the subtyp
210 his includes understanding how the Envelope (Env) protein of these virions interacts with the T-cell
211 t peptide in the Vr1 region of the envelope (Env) proteins of feline leukemia virus (FeLV) subgroups
214 aced by that of the wild-type or mutant MuLV Env protein or in which the cytoplasmic tail sequence of
215 y of SU for appropriate configuration of the Env protein or independent activation by SU of a signali
216 s received active immunizations with subunit Env protein or modified vaccinia Ankara (MVA)-vectored E
217 ect tyrosine phosphorylation of JSRV or ENTV Env proteins or an interaction between the Env proteins
218 gether, these studies indicate that the MMTV Env protein participates in mammary epithelial cell tran
219 erate in culture; express Tax, Rex, Gag, and Env proteins persistently; and transmit HTLV-1 to naive
221 method could influence the proportion of an Env protein population that contained aberrant disulfide
223 eneral, the alanine mutations did not affect Env protein production or its localization to the plasma
224 fficiency and fusion competency of the viral Env proteins relate to infection during this transition
225 erior envelope glycoprotein (Env), nonnative Env protein released from cells, and the glycan shieldin
227 ous data have shown that the HIV-1 Envelope (Env) protein requires an interaction with MA for assembl
228 trimer complex showed additional contacts to Env protein residues by SF12 compared with VRC-PG05, the
229 and that at least two of the most expressed Env proteins retain their ability to make a protein.
230 e always replaced, both coding for envelope (Env) protein segments: the N terminus of the surface sub
231 unodeficiency virus type 1 (HIV-1) envelope (Env) protein serves as a barrier to antibody-mediated ne
232 accines and therapeutics targeting the HIV-1 Env protein should consider virus variation within indiv
234 ans when using the SHIV/macaque model, HIV-1 Env proteins should be identified that use mCD4 as a fun
235 ion to the V5 variable loop of the envelope (Env) protein showed that viruses bearing HI insertions r
236 croscopy performed on the BG505 SOSIP mutant Env proteins shows rearrangements in the gp120 topologic
237 ncreased breadth of recognition of different Env proteins, suggesting anti-V regions 1 and 2 Abs may
238 iable domain (V2) of the HIV gp120 envelope (Env) protein, suggesting this region as a target for vac
240 revealed that glycans masked most of the SIV Env protein surface, with ITS90 targeting a glycan hole,
241 lowed by two doses of NYVAC vector and gp120 Env protein; T2 comprised four doses of NYVAC vector and
242 mprised four doses of NYVAC vector and gp120 Env protein; T3 was two doses of DNA vector followed by
245 HIV-1 B/C recombinant, native-like trimeric Env protein that is highly resistant to CD4-induced conf
246 Here, we identified several soluble gp140 Env proteins that are recognized by PG9 and PG16, and we
247 trimer adds to the repertoire of native-like Env proteins that are suitable for immunogenicity and st
249 bored genetically and phenotypically diverse Env proteins that used CCR5 and/or CXCR4 to elicit membr
251 ansmitted to infants IP, but not IU, encoded Env proteins that were shorter and had fewer putative N-
253 unodeficiency virus type-1 (HIV-1) envelope (Env) proteins that mediate membrane fusion represent a m
254 perties of the viral envelope glycoproteins (Env proteins) that influence the ability of HIV-1 to ind
255 T cell responses engendered was against the Env protein, the Mamu-A*02-restricted epitope, Env(788-7
256 nclude that for both X4-tropic and R5-tropic Env proteins, the CT facilitates conformational changes
258 ate the cell surface expression of envelope (Env) proteins through peptide sequences located in the c
259 roglial precursor cells were stimulated with ENV protein to determine the effects of this ligand/rece
261 of anti-Env Abs can be improved by coupling Env proteins to costimulatory molecules such as a prolif
262 MAbs, C108g did not block binding of soluble Env proteins to either the CD4 or the CCR5 receptor, but
263 ining synthetic Galcer and recombinant HIV-1 Env proteins to identify antibodies that would block the
264 which multivalent binding of trimeric HIV-1 Env proteins to MA trimers contributes to the process of
265 t that multivalent binding of trimeric HIV-1 Env proteins to MA trimers contributes to the process of
266 membrane (PM) assembly sites where envelope (Env) protein trimers are incorporated into virus particl
267 TANCE The mechanism by which HIV-1 envelope (Env) protein trimers assemble into virus particles is po
268 egimens that delayed administration of gp120 Env protein until the 3-month vaccination (groups T1 and
271 eceptor responses to SHIV(AD8) infection and Env protein vaccination with eight different adjuvants.
274 idual represents a source of closely related Env protein variants that can be used to explore various
276 ch the cytoplasmic tail sequence of the MuLV Env protein was added to the HA cytoplasmic domain.
277 lated on serine residues, but the native BLV Env protein was not phosphorylated either in transfected
279 t to the plasma membrane of selected deleted Env proteins was confirmed by confocal immunofluorescenc
280 among targeting peptides of library-selected Env proteins was greater than that found in parental FeL
281 he NXT/S N-linked glycosylation motif of the Env protein, we created 27 mutants lacking 1 to 5 of 14
283 xplore whether Tier-2 nAbs can be induced by Env proteins, we immunized conventional mice with solubl
284 st, viruses pseudotyped with subtype A and C Env proteins were able to use the recently described alt
288 simian immunodeficiency virus (SIV) Gag and Env proteins were used to vaccinate rhesus macaques with
289 ave created a RV containing a chimeric HIV-1 Env protein, which contains introduced cysteine residues
290 We postulated that co-administration of Env protein with either a DNA or NYVAC vector during pri
291 ergent in sequence, the two viruses share an Env protein with similarly curtailed VRA and VRB regions
292 protein, show that interaction of the viral Env protein with the virus entry receptor Hyal2 is not r
294 d the disulfide bond profiles of two soluble Env proteins with different designs that are being asses
298 eld, showing an abundance of oligomannose on Env protein, with 40 to 50% of glycans being Man(5) to M
299 ccinia Ankara (MVA)-vectored Env and subunit Env protein, with or without a single intravenous coadmi
300 antibodies was highest against HIV-1 clade C Env proteins, with considerable cross-reactivity to othe