ライフサイエンスコーパス: Et

1 Ets DNA binding, selectivity, and regulation have been e

2 Ets family transcription factors regulate many aspects o

3 Ets homologous factor (EHF) is a key member of the trans

4 Ets homologous factor (EHF) is an Ets family transcripti

5 Ets Related Gene (ERG) is a component of normal and leuk

6 Ets transcription factors, which share the conserved Ets

7 Ets variant 2 (Etv2), a member of the E26 transforming-s

8 Ets-1 deubiquitination blocks its proteasomal destructio

9 Ets-2 acts as an independent preinduction repressor in n

10 Ets-2 binding to ARRE-2 in chromatin is stronger in naiv

11 Ets-2 silences directly constitutive or induced IL-2 exp

12 Ets-2, like its closely related homologue Ets-1, is a me

13 enediamines, such as derivatives 1(Me) and 1(Et), in both the solid-state and solution phases.

14 ) ethyl complexes, (PONOP)M(C2H5) (M = Ir (1-Et), Rh (2-Et)) and the iridium(I) propyl complex (PONOP

15 stal structure of a DNA complex of the Ets-2 Ets domain.

16 y available alane amine adduct (H(3)Al.NMe(2)Et) in toluene resulted in the formation of a conjugated

17 -SiR(3)(+)(C(6)F(5))(4)B(-) (SiR(3) = SiMe(2)Et, SiHEt(2)) and (Xantphos)Pd-SiR(3)(+)(BAr(f)(4)) (SiR

18 hos)Pd-SiR(3)(+)(BAr(f)(4)) (SiR(3) = SiMe(2)Et, SiHEt(2); Xantphos = 4,5-bis(diphenylphosphino)-9,9-

19 2; R(1) = Ph, R(2) = Naph, L3; R(1) = R(2) = Et, L4; R(1) = R(2) = Cy, L5; R(1) = R(2) = (t)Bu, L6),

20 s [P(3)O(8)NR(1)R(2)](2-) (2a: R(1) = R(2) = Et; 2b: R(1) = H, R(2) = (t)Bu) in greater than 70% yiel

21 nyl cluster, [(UO(2))(3)(Cy(7)Si(7)O(12))(2)(Et(2)O)(MeCN)(2)] (2), as yellow rods in 42% isolated yi

22 esence of catalytic systems Ti(acac)(2)Cl(2)-Et(2)AlCl and Co(acac)(2)(dppe)/Zn/ZnI(2) was performed

23 tion conditions with either the BF(3).OEt(2)/Et(3)SiH or TFA/BH(3).THF combinations.

24 Therefore, despite high levels of ERK1/2, Ets-1 target genes including DUSP6 and cyclins D1, D3, a

25 -(EtH)(+)), was prepared by protonation of 2-Et at -150 degrees C.

26 plexes, (PONOP)M(C2H5) (M = Ir (1-Et), Rh (2-Et)) and the iridium(I) propyl complex (PONOP)Ir(C3H7) (

27 d through an Ir(V) complex ((carb)PNP)Ir(H)3(Et) which reductively eliminates ethane with a very low

28 The reaction of 2 with BF(3)Et(2)O affords the borylated derivative (3).

29 3) in DMF at 100 degrees C for 18 h or BF(3).Et(2)O at rt.

30 n of water, whereas in the presence of BF(3).Et(2)O bond migration took place preferentially.

31 uminyl by abstraction of pyridine with BF(3).Et(2)O unexpectedly led to a B/Al metathesis with the pr

32 ditions (HCl, montmorillonite K10, and BF(3).Et(2)O) were studied.

33 used phenazines was developed via PIFA-BF(3).Et(2)O-mediated oxidative coupling of di-heteroarylated

34 BF(3).Et(2)O-mediated synthesis of multisubstituted indenes fr

35 l)benzo[e]indoles, upon treatment with BF(3).Et(2)O/Et(3)N, afforded a new type of fluorescent boron

36 ain-specific homeobox/POU domain protein 3b, Ets variant gene 1, substance P, somatostatin, vasoactiv

37 able Th(III) complex in the salts [K(THF)(5)(Et(2)O)][Th(OC(6)H(2)(t)Bu(2)-2,6-Me-4)(4)] and [Li(THF)

38 L = {(ArNH)(ArN)-C=N-C=(NAr)(NHAr)}; Ar =2,6-Et(2)-C(6)H(3)] with a commercially available alane amin

39 the formation of the cluster species [Fe(8) Et(12) ](2-) , a rare example of a structurally characte

40 Attempts to generate a Et(2)O-free version of 1 resulted instead in a dinuclear

41 ducts in the presence or absence of an added Et(3)N, respectively.

42 In addition, Ets-1 is located in both the nucleus and cytoplasm of re

43 le for Etv2 that is mediated by two adjacent Ets motifs in the proximal promoter.

44 Although Ets-1 negatively regulates the expression of Blimp1, a k

45 ar import mechanism of NRF-2 is unique among Ets factors.

46 g of c-Jun (an AP-1 factor) and Etv5/ERM (an Ets factor) to these regions in lens chromatin.

47 Etv2, an Ets-transcription factor, governs the specification of t

48 We sought to define the role of Etv5, an Ets-family transcription factor, in TH17 cell developmen

49 tion site 1 (Fli-1) transcription factor, an Ets family member, is implicated in the pathogenesis of

50 Ets homologous factor (EHF) is an Ets family transcription factor expressed in many epithe

51 SPIB is an Ets transcription factor that is expressed exclusively i

52 o motif as a hybrid bioisostere of CF(3) and Et (BITE) in a series of modified barbiturate inhibitors

53 n, and cyclization with acetic anhydride and Et(3)N.

54 Cl] in the presence of hydrazine hydrate and Et(3)N affords a Cn(-) complex of copper(I), [(Cn(-))Cu(

55 riptive embryology, skeletogenesis in Sp and Et has long been known to occur by distinct means.

56 PU.1 and Ets-1 represent archetypes for studying site discriminat

57 wo sequence-divergent ETS homologs, PU.1 and Ets-1, to DNA sites harboring a hemi- and fully methylat

58 egulatory regions contain arrays of AP-1 and Ets-binding sites.

59 ibility to dimethyl sulfate for PU.1/DNA and Ets-1/DNA complexes, indicating that the dynamics of PU.

60 The IRF and Ets families of transcription factors regulate the expre

61 ducible transcription factors, NF-kappaB and Ets-1, to the locus.

62 2 mRNA expression, Ets-2 protein levels, and Ets-2 binding to ARRE-2 decrease upon cell activation fo

63 y demonstrated important roles for Mesp1 and Ets variant 2 (Etv2) during lineage specification, but t

64 s-1 precedes rapid nuclear entry of NFAT and Ets-1 deficiency results in impaired nuclear entry, but

65 Usp9x and Ets-1 levels are coincidently elevated in melanoma with

66 Both Ets1, another Ets family member, and Fli-1 drive transcription from th

67 treatment with alkyl metal reagents, such as Et(2) Zn and Bu(2) Mg.

68 ently with even weak terminal bases, such as Et(3)N.

69 strained spacing-Ets and Homeobox as well as Ets and E-box.

70 mposite elements (AICEs) and with TF PU.1 at Ets-IRF composite elements (EICEs), it is unclear how th

71 of Etv2 at midgestation, binding of Etv2 at Ets-binding sites in the Fli1 promoter is replaced by Fl

72 tions of E4 cardiomyocytes prove optimal at ~Et,E4 both in vivo and in vitro.

73 g the highly reactive bromenium source BDSB (Et(2)SBr.SbCl(5)Br), can lead to concise asymmetric tota

74 osome 11p13, is an intergenic region between Ets homologous factor (EHF) and Apaf-1 interacting prote

75 A formally iron(0) ate complex [ (iPr)BIPFe(Et)(CH(2)=CH(2))](-) was identified as the principle res

76 Both Ets and Gata factors have been shown to have important r

77 Both GABP and PU.1 bound Ets sites in the Lbr promoter in vitro, and in vivo with

78 1/p-X-C6H4OH (rho = -3.3 for X = OMe, t-Bu, Et, and Me; rho = +1.5 for X = F, Cl, and CF3).

79 derivatives of cyanoacetic acid catalyzed by Et(3)N is presented.

80 in catalytic CO(2) and Ph(2) CO reduction by Et(3) SiH and hydrogenation of 1,1-diphenylethylene usin

81 radicals linked by iodides and separated by Et(4) N(+) counter-ions.

82 1) does not rescue the expression of IL-2 by Ets-1-deficient Th cells.

83 unique bipartite mode of ERK2 engagement by Ets-1 and involves two suboptimal noncanonical docking i

84 e the highly specific recognition of ERK2 by Ets-1, and enable the optimal localization of its dynami

85 e promoter may be predominantly regulated by Ets at the dorsal midline and are expressed in a ring.

86 In naive Th cells, Ets-2 mRNA expression, Ets-2 protein levels, and Ets-2 b

87 Versus a CGC(Et)Ti + SNSCr tandem catalyst, Ti-C0-Cr(SNS) yields poly

88 y titanium olefin polymerization center (CGC(Et)Ti) covalently linked to a chromium bis(thioether)ami

89 ly, those achieved by tandem mononuclear CGC(Et)Ti and SNSCr catalysts under identical reaction condi

90 In contrast, the tandem CGC(Et)Ti + SNSCr system yields 91.0% n-propyl branches unde

91 The R groups were CF3, CHO, COMe/Et, CO2Me, CONMe2/Et2, H, and 1-propynyl.

92 r via two identical, but inverted, composite Ets/E-box motifs enclosing the core promoter.

93 scription factors, which share the conserved Ets DNA-binding domain, number nearly 30 members in huma

94 , we report that Fli1 binds to the conserved Ets-binding sites within promoter and enhancer regions o

95 We demonstrate that Etv2 binds to conserved Ets-binding sites within the promoter region of the Fli1

96 oter region of SAM-pointed domain-containing Ets-like factor (SPDEF), a driver of mucous differentiat

97 he promoter of SAM-pointed domain-containing Ets-like factor (SPDEF), a known factor for goblet cell

98 Conversely, Ets-2 silencing allows for constitutive IL-2 expression

99 ation by creating signaling-incompetent Dome:Et/Lat heterodimers.

100 Tissue elasticity, Et, increases daily for heart to 1-2 kPa by embryonic da

101 ibute utility theory (MAUT), and Elimination Et Choix Traduisant la REalite (ELECTRE III).

102 manner that recapitulates that of endogenous Ets-1 expression in the neural crest.

103 Fli-1 binds to endogenous Ets binding sites in the distal region of the CCL5 promo

104 We have identified regions flanking the ERG Ets domain responsible for autoinhibition of DNA binding

105 increases membrane permeability to ethidium (Etd(+)) and Ca(2+) by activating P2X7 receptors (P2X7Rs)

106 L alone or in combination with ethionamide (Et), amikacin (A), and Z given for 2 or 7 months.

107 , five compounds [R = butyl (Bu), R = ethyl (Et), R = methoxymethyl (MeOMe), R = methyl (Me), and R =

108 Ewing Sarcoma pathogenesis is driven by EWS/Ets fusion oncoproteins, of which EWS/Fli1 is the most c

109 Driven by EWS/Ets, or rarely variant, oncogenic fusions, Ewing Sarcoma

110 Erf is a gene for a ubiquitously expressed Ets DNA-binding domain-containing transcriptional repres

111 In naive Th cells, Ets-2 mRNA expression, Ets-2 protein levels, and Ets-2 binding to ARRE-2 decrea

112 kinase substrates, the transcription factor Ets-1 has no canonical docking motifs, yet it is efficie

113 We found that the transcription factor Ets-1 is highly expressed in KS spindle cells and is upr

114 cific expression of the transcription factor Ets-1, located within one of these loci on chromosome 8,

115 memory, Th cells by the transcription factor Ets-2 that binds to the antigen receptor response elemen

116 This metal-free, Et(3)N-catalyzed cascade reaction proceeded with exclusi

117 hexanes, followed by recrystallization from Et(2)O/MeCN, results in the formation of the uranyl clus

118 S rats and SS rats with only one functioning Ets-1 gene (ES rats) demonstrated similar increases in B

119 H, Me) are superior to bulkier groups (e.g., Et, pTol), and a Mes substituent is even prohibitively l

120 ing sites that were also enriched for Gata1, Ets, and Runx1 motifs.

121 nature of the remote substituent along Me > Et > iPr and oligomer molecular weights increase.

122 Dynamic (1)H NMR characterization of 1-(H)(Et)(+) establishes site exchange between the Ir-H and Ir

123 hylene through formation of ((carb)PNP)Ir(H)(Et)(C2H4) and by H2 through formation of ((carb)PNP)Ir(H

124 ethane from Ir(III) complex ((carb)PNP)Ir(H)(Et)(H2) is calculated to proceed through an Ir(V) comple

125 by H2 through formation of ((carb)PNP)Ir(H)(Et)(H2).

126 f putative binding sites for SoxE, homeobox, Ets, TFAP2 or Fox proteins results in loss or reduction

127 Ets-2, like its closely related homologue Ets-1, is a member of the Ets family of DNA binding tran

128 HTy and HTy-Et also altered the transcription of specific genes invo

129 -Xantphos)Ni(I) -Me and (tBu-Xantphos)Ni(I) -Et complexes undergo fast insertion of CO(2) at 22 degre

130 Facile Pt(II)-Et functionalization was determined to occur via a low e

131 are either missing or operate differently in Et.

132 2-cryptand), 1-Tb, reacts with dinitrogen in Et(2)O at -35 degrees C to form the end-on bridging dini

133 The overall increase in Et over land is about twofold of the decrease in Es.

134 ificantly (p < 0.01), caused by increases in Et and Ei, which are partially counteracted by Es decrea

135 tration, contraction wave speed is linear in Et as theorized for excitation-contraction coupled to ma

136 croglia are not required for the increase in Etd(+) uptake by astrocytes induced by FGF-1, although t

137 1 and carbenoxolone) prevent the increase in Etd(+) uptake by astrocytes, whereas Gap19, a selective

138 ear evidence for the allosteric mechanism in Ets-2.

139 esence of an autoinhibitory module, which in Ets-1 allosterically inhibits the DNA binding activity.

140 by preventing Akt activity and inactivating Ets-1 function in NSCLC cells.

141 rs involved in IE gene expression, including Ets, AP-1, CREB, and C/EBP, which lead to the transient

142 HV latent vFLIP gene is sufficient to induce Ets-1 expression in an NF-kappaB-dependent fashion.

143 ET-1 induced Ets-like kinase-1 (Elk-1), signal transducer and activat

144 Instead, Ets-1 physically and functionally interacts with the nuc

145 ether, these results uncover new inputs into Ets-1, revealing critical links in the cranial neural cr

146 : NRF-2alpha, which binds to DNA through its Ets domain, and NRF-2beta, which contains the transcript

147 Up to 2.5 mug/L Et-Ph3P(+) was quantified in a small stream from the Hes

148 n the back reaction rapidly leads to labeled Et-S-CoM, which enables intermediate formation to be det

149 ely acting receptor, Eye Transformer/Latran (Et/Lat).

150 activated or memory Th cells; in the latter, Ets-2 participates in a change of the IL-2 promoter arch

151 tituents slow the reaction in the order Me < Et < (i)Pr < (t)Bu.

152 t also Akt activity is essential to maintain Ets-1 in an active state.

153 dT lesions, with the alkyl group being a Me, Et, nPr, iPr, nBu, iBu or sBu, at a defined site and exa

154 dT lesions, with the alkyl group being a Me, Et, nPr, iPr, nBu, iBu, (R)-sBu and (S)-sBu, are recogni

155 dG lesions, with the alkyl group being a Me, Et, nPr, iPr, nBu, iBu, or sBu, in several human cell li

156 Cyclophanes bearing Me, Et, and MeO cap substituents and beta-Me, Et, or Ph arm

157 e, Et, and MeO cap substituents and beta-Me, Et, or Ph arm substituents are obtained, and a modified

158 dipp)][B(Ar(F))4] (1R[B(Ar(F))4]; R = H, Me, Et; Ar(F) = C6H3-3,5-(CF3)2; Idipp = C[N(C6H3-2,6-iPr2)C

159 f the form WN(NR2)3 [R = combinations of Me, Et, (i)Pr, (n)Pr] have been synthesized as precursors fo

160 es the conversion of N2 to N(SiR3)3 (R = Me, Et) at room temperature, representing the highest turnov

161 plexes (DNICs) [((R)DDB)Fe(NO)2](+) (R = Me, Et, Iso; (R)DDB = N,N'-bis(2,6-dialkylphenyl)-1,4-diaza-

162 The size (Me, Et, iPr, and tBu) and position (meta and para) of the al

163 of spiroindolenines from 2-substituted (Me, Et) indoles and 2-(pyrrolidin-1-yl)benzaldehydes has bee

164 strocytes that show enhanced Px1 HC-mediated Etd(+) uptake.

165 tivity is dependent on a likely Fgf-mediated Ets transcription factor-binding site.

166 Within a minimal Ets-1 enhancer region, mutation of putative binding site

167 expression was easily rescued under modelled Ets-factor gain of function, as occurs in TERT promoter

168 FeMoco and an analogous small-molecule (Et(4) N)[(Tp)MoFe(3) S(4) Cl(3) ] cubane have both been

169 leads to the intermediate, (eta(5)-C5Me5)[N(Et)C(Ph)N(Et)]Mo(Cl)(NHSiMe3) (V), and XOSiMe3 as a co-p

170 IV) terminal imido complex, (eta(5)-C5Me5)[N(Et)C(Ph)N(Et)]Mo(NSiMe3) (3), with a 1:2 mixture of iPrO

171 n of the Mo(IV) dichloride, (eta(5)-C5Me5)[N(Et)C(Ph)N(Et)]MoCl2 (1), and the generation of 1 equiv e

172 the intermediate, (eta(5)-C5Me5)[N(Et)C(Ph)N(Et)]Mo(Cl)(NHSiMe3) (V), and XOSiMe3 as a co-product.

173 al imido complex, (eta(5)-C5Me5)[N(Et)C(Ph)N(Et)]Mo(NSiMe3) (3), with a 1:2 mixture of iPrOH and Me3S

174 o(IV) dichloride, (eta(5)-C5Me5)[N(Et)C(Ph)N(Et)]MoCl2 (1), and the generation of 1 equiv each of HN(

175 (2)(N-Et-HPTB)(NO)(DMF)(3)](BF(4))(3) (1) (N-Et-HPTB is the anion of N,N,N',N'-tetrakis(2-(l-ethylben

176 x 1 ([Mn2 (O2 CCH3 )(N-Et-HPTB)](ClO4 )2 , N-Et-HPTB=N,N,N',N'-tetrakis(2-(1-ethylbenzimidazolyl))-2-

177 de a dinitrosyl diiron(II) complex, [Fe(2)(N-Et-HPTB)(NO)(2)(DMF)(2)](BF(4))(3) (2) with [{FeNO}(7)](

178 ed mononitrosyl diiron(II) complex, [Fe(2)(N-Et-HPTB)(NO)(DMF)(3)](BF(4))(3) (1) (N-Et-HPTB is the an

179 xed-valent diiron(II, III) complex, [Fe(2)(N-Et-HPTB)(OH)(DMF)(3)](BF(4))(3) (3).

180 Complex 1 ([Mn2 (O2 CCH3 )(N-Et-HPTB)](ClO4 )2 , N-Et-HPTB=N,N,N',N'-tetrakis(2-(1-et

181 Reaction of [Fe2(N-Et-HPTB)(CH3COS)](BF4)2 (1) with (NO)(BF4) produces a no

182 -Et-HPTB)(O2CPh)(NO)2](BF4)2 (1a) and [Fe2(N-Et-HPTB)(DMF)2(NO)(OH)](BF4)3 (2a), are characterized by

183 heme mononitrosyl diiron(II) complex, [Fe2(N-Et-HPTB)(NO)(DMF)3](BF4)3 (2).

184 Two non-heme iron-nitrosyl species, [Fe2(N-Et-HPTB)(O2CPh)(NO)2](BF4)2 (1a) and [Fe2(N-Et-HPTB)(DMF

185 c (MAZ) compounds of the type EtZn-(R''-Zn)n-Et (R'' = ethyl and propyl branched alkylene groups) wer

186 2-2,6)NCMe}2CH](-); R = Pr(i) ((Dip)Nacnac), Et ((Dep)Nacnac)) using 1,3-cyclohexadiene.

187 elevant to an emerging role of PU.1, but not Ets-1, as a pioneer transcription factor in vivo.

188 robustly bound fully methylated DNA, but not Ets-1, which was substantially inhibited.

189 pled to site discrimination by PU.1, but not Ets-1.

190 Notably, Ets-1 is induced by BRAF or MEK kinase inhibition, resul

191 as embryonically lethal, a single-nucleotide Ets motif mutant was viable, and steady-state hematopoie

192 ASO designs comprised of short S-cEt (S-2'-O-Et-2',4'-bridged nucleic acid) gapmer ASOs, approximatel

193 synthesized in the presence of N-Fmoc and O-Et protected phosphoserine and phosphotyrosine to prepar

194 [e]indoles, upon treatment with BF(3).Et(2)O/Et(3)N, afforded a new type of fluorescent boron complex

195 in the presence of stoichiometric amounts of Et(3)N in dichloroethane at 80 degrees C.

196 If 1-Gd is dissolved in THF instead of Et(2)O under N(2), the irreversible formation of an (N(2

197 ith 2 months of EtZA followed by 5 months of Et or EtZ.

198 to the molecular mechanism and regulation of Et/Lat in Drosophila that may inform our understanding o

199 ed by autocrine IL-6 and inhibits accrual of Ets-1, Set1 methyltransferase and trimethylation of hist

200 cognition sequence and the mode of action of Ets post-translational modifications.

201 ely blocks the transcriptional activation of Ets-1, which inhibits its target gene, dual specificity

202 ization did not occur with the ETS domain of Ets-1, a close structural homolog of PU.1, 2:1 complex f

203 f DNA site recognition by the ETS domains of Ets-1 and PU.1, which represent the extremes in amino ac

204 This nuclear exit of Ets-1 precedes rapid nuclear entry of NFAT and Ets-1 def

205 ogram, including the sustained expression of Ets transcription factors such as ETV1 Together, our dat

206 oapoptotic genes and decreased expression of Ets-1 and other hematopoietic genes.

207 ble the autoinhibited and DNA bound forms of Ets-1.

208 Mutations of Ets or E-box sites in either DNA motif abolished the act

209 In contrast, the C-terminal region of Ets-1, including its Pointed (PNT) domain, engages in a

210 mediated predominantly by the regulation of Ets-domain dynamics with only modest structural changes.

211 ge effects are dependent on de-repression of Ets transcription factors.

212 The N terminus of Ets-1 interacts with a part of the ERK2 D-recruitment si

213 n-releasing group (kH/kD = 1.7-2.5; X = OMe, Et), whereas an inverse isotope effect was measured for

214 carried out targeted functional analyses on Et skeletogenesis to identify the presence, or demonstra

215 rol the activity of this subset of oncogenic Ets transcription factors.

216 yridinium salts and either Hantzsch ester or Et(3) N, photoinduced single-electron transfer could be

217 g A) and 13(2) carboalkoxy groups (R = Me or Et) were constructed in 37-61% yield from the hydrobilin

218 ranes, [RR'PBH(2)](n) (R = Ph; R' = H, Ph or Et), or are trapped in the form of CAAC-phosphinoborane

219 polymers, [RR'PBH(2)](n) (R = Ph; R' = Ph or Et).

220 tations in certain E-box, NFkappaB, MEF2, or Ets family binding sites--known to be important for the

221 were obtained with the p-Me, m,p-diMe, and p-Et phenyl derivatives 3c, 3e, and 3f, respectively, and

222 the anionic, trivalent, terbium precursor, [(Et(2)O)K][Tb(NP(1,2-bis-(t)Bu-diamidoethane)(NEt(2)))(4)

223 CH2CH3 insertion products, (C5Me5)2Y[(i)PrNC(Et)N(i)Pr-kappa(2)N,N'], 4, and [(C5Me5)2Y(mu-O2CEt)]2,

224 de ligand (trans-[Ni(F)(2-C5NF4)(PR3)2], R = Et 1a, Cy 1b, trans-[Pd(F)(4-C5NF4)(PCy3)2] 2, trans-[Pt

225 esters [P(3)O(9)R](2-) (3a: R = Me; 3b: R = Et) in greater than 60% isolated yield.

226 ecursor 8 with 1 molar equiv of K[BHR3] (R = Et, sBu) in THF at room temperature.

227 Interestingly, when K[BHR3] (R = Et, sBu) is employed as a hydride source to react with 3

228 aturing a mesityl (R = Mes) or an ethyl (R = Et) substituent initiate the living ring-opening alkyne

229 iCH3(pyridine)] (1a-pyr, R = Me; 1b-pyr, R = Et; 1c-pyr, R = iPr) convert ethylene to hyperbranched l

230 [Ge9R3R'](0), where R = Si(SiMe3)3 and R' = Et (1), Sn(n)Bu3 (2), or Tl (3).

231 the composition Au(32) (R(3) P)(12) Cl(8) (R=Et, (n) Pr, (n) Bu) were synthesized in a straightforwar

232 erizations of rac-8DL(Me) with rac-8DL(R) (R=Et, Bu) have yielded high-molecular-weight, crystalline

233 behavior of the related dimer beta-1a (R1 = Et, R2 = F), which readily dissociates into a pair of ra

234 Alkyl Grignard reagents (Et, (n)Bu, (i)Pr, cyclohexyl), with the exception of (t)

235 vestigate the specific contribution of renal Ets-1, we transplanted kidneys from ES or SS rats into s

236 Prior binding of the repressive Ets transcription factor Etv6 predicts cohesin binding a

237 Bioinformatic analysis revealed Ets binding sites on the miR-155 promoter, and we found

238 or cooperative binding to closely separated Ets binding sites in a palindromic arrangement.

239 Ethyl-coenzyme M (CH3CH2-S-CH2CH2-SO3(-), Et-S-CoM) serves as a homologous substrate for the enzym

240 ) catalyst and nucleophilic fluoride source (Et(3)N.3HF), allylic trichloroacetimidates undergo rapid

241 unknown motif-pairs with constrained spacing-Ets and Homeobox as well as Ets and E-box.

242 The E26 transformation-specific (Ets-1) transcription factor is autoinhibited by a confor

243 Cyclosporine A stabilizes Ets-2 mRNA and protein when the cells are activated.

244 attering showed PU.1 to be more dynamic than Ets-1; moreover, dynamic changes are strongly coupled to

245 ce a more stringent sequence preference than Ets-1 and its proximal sequence homologs.

246 We demonstrate that Et/Lat negatively regulates the JAK/STAT pathway activit

247 Surprisingly, we find that Et/Lat is able to bind to both JAK and STAT92E but, desp

248 We find that Et/Lat is trafficked through the endocytic machinery for

249 We propose that Ets-2 expression and protein binding to the ARRE-2 of th

250 Here we report that Ets-1 destruction is regulated by the deubiquitinating e

251 The Et groups can be easily replaced with F atoms using BF3.

252 switch from N-methylimidazole (N-MI) to the Et(3)N N-ligand efficiently alters diastereoselectivity

253 The Ets domain crystallized with two distinct species in the

254 The Ets-Related Gene (ERG) belongs to the Ets family of tran

255 e for Forkhead transcription factors and the Ets transcription factor Etv2, for activity in vivo.

256 ne transcription, which responds to both the Ets domain-containing protein Elk1 (Elk1) and the glucoc

257 on between Etv2 and Gata2 is mediated by the Ets and Gata domains.

258 In Drosophila, the Ets protein Pointed P1 (PntP1) is required to generate I

259 Among these genes the Ets-related gene (ERG) is the most frequently overexpres

260 However, the Ets motif mutation abrogated stem/progenitor cell regene

261 Thus, Usp9x modulates the Ets-1/NRAS regulatory network and may have biologic and

262 sic nuclear localization signals (NLSs): the Ets domain within NRF-2alpha and the NLS within NRF-2bet

263 related homologue Ets-1, is a member of the Ets family of DNA binding transcription factors.

264 Here we show that depletion of the Ets family transcription factor GA-binding protein (GABP

265 ow that mice with homozygous deletion of the Ets transcription factor Erg die between embryonic day 1

266 on crystal structure of a DNA complex of the Ets-2 Ets domain.

267 and neither mutant was able to regulate the Ets/IRF composite element or interferon-stimulated respo

268 The Ets-Related Gene (ERG) belongs to the Ets family of transcription factors and is critically im

269 nd form a long-lived complex relative to the Ets-1 counterpart.

270 ding of c-Myc and ETS family proteins to the Ets/E-box motifs derepresses the hTERT promoter by induc

271 y for astrocyte differentiation in which the Ets protein Pointed and the Notch signaling pathway are

272 ow that Btd functions cooperatively with the Ets transcription factor Pointed P1 to promote the gener

273 rcular dichroism (XMCD) spectroscopy of the (Et(4) N)[(Tp)MoFe(3) S(4) Cl(3) ] cubane and Fe L(2,3) -

274 Thus, Ets transcription factors specify non-vascular, amniotic

275 Thus, Ets-1 is a novel regulator of VEGFR3 and is involved in

276 Thus, Ets-1 promotes the expression of IL-2 by modulating the

277 th the transcription factors PU.1 or BATF to Ets or AP-1 composite motifs, associated with genes invo

278 In contrast to Ets-1, in which the autoinhibition is caused by a combin

279 ty and that the increase in INPP4B is due to Ets-1-mediated transcriptional upregulation in colon can

280 Sp), vs. the cidaroid Eucidaris tribuloides (Et).

281 treated in the same pot with triethylamine (Et(3)N), leading to the selective formation of C3-substi

282 estigate the molecular mechanisms underlying Et/Lat activity.

283 ort a palladium-catalyzed C-N coupling using Et(3)N as a weak, soluble base, which allows a broad sub

284 e components: transpiration from vegetation (Et), direct evaporation from the soil (Es) and vaporizat

285 g proliferation and an OPC-like identity via Ets overactivity.

286 heir MI block index strategy: adjunctive VOM-Et and RFCA alone.

287 (63.8+/-9.4 years) undergoing adjunctive VOM-Et for MI block.

288 ght to evaluate the impact of adjunctive VOM-Et on MI block achievement and durability compared with

289 Beyond facilitating acute MI block, VOM-Et is associated with greater lesion durability as evide

290 vein of Marshall (VOM) ethanol infusion (VOM-Et) can facilitate acute MI block.

291 tients exhibited durable MI block in the VOM-Et group (62.9% [22/35] versus 32.6% [15/46], respective

292 lock was more frequently achieved in the VOM-Et group (98.7% [150/152] versus 63.6% [70/110]; P<0.001

293 The VOM-Et group consisted of 152 patients (63.8+/-9.4 years) un

294 ent a repeat procedure during follow-up (VOM-Et group: 23.3% [35/150] versus RFCA group: 65.7% [46/70

295 eric demand of the polymer end-group (Mes vs Et) transferred during the initiation step determines th

296 bis-(t)Bu-diamidoethane)(NEt(2)))(4)] (where Et is ethyl and (t)Bu is tert-butyl).

297 data suggest two distinct mechanisms wherein Ets-1 follows a "dry" mechanism that rapidly parses site

298 used in catalytic amounts when combined with Et(3)N.HBr/TMSBr, which acts as a regenerating system.

299 es of cooperative binding to substrates with Ets binding motifs separated by four and six base pairs

300 -diethyl-2,2-dimethyl-pyrrolidin-5-ylidene ((Et)CAAC) were discovered to afford three different types