ライフサイエンスコーパス: F1 hybrid

1 nbred lines B73 and Mo17 produce a heterotic F1 hybrid.

2 s in D. melanogaster, D. simulans, and their F1 hybrid.

3 crease in genome-wide DNA methylation in the F1 hybrid.

4 abundance of species-specific transcripts in F1 hybrids.

5 ross between C3H/HeJ(+/wan) and CAST/Ei(+/+) F1 hybrids.

6 synaptonemal complexes of annual x biennial F1 hybrids.

7 Only a subset of these would act in F1 hybrids.

8 and aggressive behaviour of their reciprocal F1 hybrids.

9 is variable in synthetic Arabidopsis suecica F1 hybrids.

10 C57BL/6 phenotype is dominant in reciprocal F1 hybrids.

11 ility of both male and female gametes in the F1 hybrids.

12 ng female rats of six inbred strains and six F1 hybrids.

13 tely 3.6% within inbred strains and isogenic F1 hybrids.

14 distinct lines of D. melanogaster and their F1 hybrids.

15 orable alleles to capitalize on heterosis in F1 hybrids.

16 as Marker-1' ('TM-1'), 'Pima 3-79' and their F1 hybrids.

17 us with different Prdm9 alleles and in their F1 hybrids.

18 ting immediate suppression of p-homeologs in F1 hybrids.

19 is and Nasonia giraulti and their reciprocal F1 hybrids.

20 -parental segregating populations instead of F1 hybrids.

21 ed vegetative and reproductive yields of the F1 hybrids.

22 o natural selection than if they were frozen F1 hybrids.

23 gger for the meiotic arrest of interspecific F1 hybrids.

24 and their segregation in (C57BL/6JxC3H/HeJ) F1 hybrids.

25 sophila melanogaster, D. simulans, and their F1 hybrids.

26 have generated a uniform genetically stable F1 hybrid (129SvEv/C57BL/6) mouse line harboring the CRE

27 metamorphic-failure species) and metamorphic F1 hybrids (A. mexicanum x A. tigrinum tigrinum).

28 mbinant inbred strains (AXB/BXA), reciprocal F1 hybrids, a chromosome (Chr) 7 consomic line, and thre

29 Comparison of reciprocal F1 hybrids allowed insights into the nature of mito-nucl

30 omictic plants maintain the phenotype of the F1 hybrid along successive generations.

31 A mixed source of parasites (containing F1 hybrids) also showed no difference in infection betwe

32 ude non-additive expression of miRNAs in the F1 hybrid and additional changes in the allopolyploid ta

33 tic regulation of PIA was investigated using F1 hybrid and congenic strain analysis to determine the

34 in the C. maxima x C. moschata interspecific F1 hybrid and their two parents indicates the predominan

35 omoting leaf growth were up-regulated in the F1 hybrids and hybrid mimics, suggesting that increased

36 mpatibility, leading to increased fitness of F1 hybrids and recovery in the F2 generation.

37 homoeologous gene pairs in the allopolyploid F1 hybrids and suggest that high-parental expression-lev

38 frequency of disrupted mtDNA transmission in F1 hybrids and suggest that two separate mechanisms, one

39 7BL/6J females with 129/SvJ males to make an F1 hybrid, and crossing F1 males to F1 females to produc

40 cumulative disease frequencies in parental, F1 hybrid, and F2 mice, derived from the EAE-susceptible

41 re we show, by using inbred strains of mice, F1 hybrids, and segregating populations, that, unlike Bp

42 an interspecies (M.musculus x M.m.castaneus) F1 hybrid animal, expression of Ipw is limited to the pa

43 mimics, in which the characteristics of the F1 hybrid are stabilized.

44 introgression is relatively common, whereas F1 hybrids are correspondingly scarce.

45 F1 hybrids are viable but sterile: the gametes they prod

46 s of Brassica napus parental lines and their F1 hybrids at three stages of early flower development.

47 In this study, autoimmune female NZB x NZW F1 hybrid (B/W) mice were tested in shock-motivated disc

48 l-described C57Bl/6 (B6)-->(C57Bl/6 x DBA/2) F1 hybrid (B6D2F1) murine model of acute allogeneic graf

49 ression was also monitored in the reciprocal F1 hybrids B73xMo17 and Mo17xB73.

50 Tumors arising in an (I/LnJ x PyMT) F1 hybrid background appeared earlier than in the FVB/N-

51 o determine whether Fmr1 knockout mice on an F1 hybrid background are normal in their response to foo

52 ve phenotype; however, deficient mice on the F1 hybrid background were resistant to cold.

53 igh frequency on C57BL/6 X FVB and C3H x FVB F1 hybrid backgrounds.

54 stickeli is likely an inviable F1 hybrid between K. c.

55 RIXs are generated by producing F1 hybrids between all or a subset of parental RI lines.

56 c gene expression in parental and reciprocal F1 hybrids between allopatric populations of Tigriopus c

57 F1 hybrids between C57BL/6 and FVB/N strains ((B6FVB)F1)

58 F1 hybrids between each of these inbred strains and the

59 We conclude that kungas were F1 hybrids between female domestic donkeys and male hemi

60 We first generated F1 hybrids between HIV-1 transgenic mice on the FVB/NJ b

61 w report that MR is relatively suppressed in F1 hybrids between inbred strains C57BL/6 and 129S2.

62 D. sechellia's resistance is dominant in F1 hybrids between it and its sister species D. simulans

63 F1 hybrids between resistant and susceptible congenic st

64 male sterility and segregation distortion in F1 hybrids between the Bogota and U.S. subspecies of Dro

65 rvivors of matings between female reciprocal F1 hybrids (between the DDK and C57BL/6J inbred mouse st

66 be potentially useful for first-generation (F1) hybrid breeding.

67 parental species result in poor fertility of F1 hybrids, but through recombination, novel homozygous

68 To define its contribution, (NZB x NZW)F1 hybrids (BWF1) containing two, one, or no copies of t

69 vey of T-cytoplasm maize lines, inbreds, and F1 hybrids by mitochondrial RNA gel blot analyses reveal

70 (BALB/cByJ, DBA/2J, C57BL/6J, and SJL/J), an F1 hybrid (C57 x SJL), and 1 outbred strain (CD1) were t

71 the associated changes in sRNA levels in the F1 hybrid can be maintained in subsequent generations an

72 F1 hybrids can outperform their parents in yield and veg

73 Heterosis is the superior performance of F1 hybrids compared with their homozygous, genetically d

74 tissue-specific increase of active genes in F1-hybrids compared with their inbred parents.

75 Centromeres are also stable in multiple F1 hybrid contexts.

76 y 105 Bos taurus indicus x Bos taurus taurus F1 hybrid control and LOS fetuses using RNAseq.

77 nts at an intensely active mouse hot spot in F1 hybrids derived from inbred mouse strains.

78 lls by natural killer cells of mice that are F1 hybrids derived from two inbred parental strains.

79 (B6.NZMc1[Sle1] x NZW)F1 hybrids develop severe humoral autoimmunity and fatal

80 Surprisingly, F1 hybrids did not produce three CHCs, and the abundance

81 genes with aberrant transcript abundance in F1 hybrids (either over- or underexpressed compared to b

82 r in mouse embryonic stem cells derived from F1 hybrid embryos.

83 ic mice died before 5 mo, almost half of the F1 hybrid eNOS(-/-) and eNOS(+/-) diabetic mice lived un

84 We generated cortical organoids from F1 hybrid EpiSCs derived from crosses between laboratory

85 terosis refers to the phenomenon in which an F1 hybrid exhibits enhanced growth or agronomic performa

86 ing, we established a system where a pair of F1 hybrids expressed either the B10 or NOD Tnfrsf9 allel

87 In C57BL/6J (B6) and (BALB x B6) F1 hybrid (F1) mice, repopulating abilities increase wit

88 Backcrossing F1 hybrid females between these two species to parental

89 Oocytes of F1 hybrid females showed the same kind of synaptic probl

90 igestion method, the resulting AR/tfm, Nu/nu F1 hybrid females were identified and back-crossed to ho

91 s offset by low genetic isolation, and lower F1 hybrid fertility increased the evolutionary independe

92 caused by a bias in the direction of initial F1 hybrid formation and subsequent backcrossing.

93 F2 progeny derived from self-pollination of F1 hybrids from four crosses (B73 x OH43, Mo17 x A632, A

94 ined Allele Specific Expression (ASE) in six F1 hybrids from Saccharomyces cerevisiae derived from cr

95 BA/2J (D2) Fog2-/+ XY(AKR) mice and (B6 x D2)F1 hybrid Gata4(ki)/+ XY(AKR) mice develop testes.

96 A GWAS in 365 transgenic F1 hybrids generated from these 20 inbred strains was pe

97 e selected heterozygotes can be recreated as F1 hybrids, greatly increasing the number of hybrids tha

98 These hybrid mimic lines, like the F1 hybrid, have larger leaves than the parent plant, and

99 fish, and parasite size was intermediate in F1 hybrid hosts.

100 criptome analysis of a number of Arabidopsis F1 hybrids identified changes to defense and stress resp

101 hylation and a lower expression level in the F1 hybrid, implying that the non-additively expressed si

102 F1 hybrids in Arabidopsis and crop species are uniform a

103 minance; and 3) increasing the proportion of F1 hybrids in the population could significantly increas

104 suppression of mitotic recombination in some F1 hybrids in which meiotic recombination persists indic

105 earlier germination as did the seeds of the F1 hybrids, indicating cosegregation of the genes for ro

106 scendants of a single nonrecombining asexual F1 hybrid individual.

107 we analyzed Mecp2(+/-) mice of two different F1 hybrid isogenic backgrounds and at young and old ages

108 The reciprocal F1 hybrid lines did not display parental effects on gene

109 llelic imbalance in the transcriptomes of 19 F1 hybrid lines from a large round robin design, we inde

110 as a large collection of clonally propagated F1 hybrid lines of Populus that saturate the genome 10-f

111 Experiments were conducted with three F1 hybrids made using three inbred strains of mice (DBA/

112 s and transgene selection was used to bypass F1 hybrid male sterility and introgress the sex distorte

113 In compliance with Haldane's rule, F1 hybrid male sterility is known to occur in all interc

114 F1 hybrid males, heterozygous at all polymorphic autosom

115 ed in D. melanogaster, to cause lethality in F1 hybrid males.

116 Analysis of backcrossed progeny of the F1 hybrids mated to Sxv mice indicates that resistance i

117 verged chromosomes to form crossovers during F1 hybrid meiosis.

118 AS F1 hybrid mice (C57BL/6J x 129) showed milder behavioral

119 netic variation were resolved by analysis of F1 hybrid mice and cells engrafted into an immunodeficie

120 ancer induction in two strains of reciprocal F1 hybrid mice CB6F1 males with high susceptibility to U

121 We used F1 hybrid mice derived from A/J and C57BL/6 matings to i

122 In contrast, infected SJL and B6xSJL F1 hybrid mice exhibit essentially complete hippocampal

123 In addition, gene expression analysis of F1 hybrid mice from CAST x FVB reciprocal crosses showed

124 ted the outcome of hybrid resistance whereby F1 hybrid mice reject parental BMCs.

125 However, C57BL/6J and B6C3 F1 hybrid mice responded with a greater number of infilt

126 scriptome analysis of Kras(G12D) tumors from F1 hybrid mice revealed features specific to tumor sampl

127 e frequency of MR in fibroblasts is lower in F1 hybrid mice than in either of the two parental strain

128 und the functional activity of CREB in these F1 hybrid mice to be dramatically reduced compared with

129 sed naturally occurring genetic variation in F1 hybrid mice to explore how DNA sequence differences a

130 ptor is responsible for the ability of H2b/d F1 hybrid mice to reject H2d/d parental BMC (hybrid resi

131 in eight organs collected from heterozygous F1 hybrid mice using ChRO-seq.

132 Post-natal day 10 129T2xC57Bl/6 F1 hybrid mice were subjected to 0, 45, 60 or 75 min of

133 C57BL/6JxCast/EiJ F1 hybrid mice were weaned onto (1) a standard natural i

134 atural genetic variation through analysis of F1 hybrid mice(5).

135 , X chromosome inactivation can be skewed in F1 hybrid mice, as determined by alleles at the X chromo

136 F1 hybrid mice, as well as parental A/J and C57BL/6 mice

137 s of >10,000 sperm and sperm precursors from F1 hybrid mice, mapping 86,786 crossovers and characteri

138 in the epidermis of K5Hras-transgenic (B6FVB)F1 hybrid mice.

139 he intertrial interval (ITI) using C57 x SJL F1 hybrid mice.

140 6J, C3H/HeJ, and (C57BL/6J x C3H/HeJ) (B6C3) F1 hybrid mice.

141 ells from 5 increasingly diverged strains of F1 hybrid mice.

142 lopment of invasive tumors, as are RT2 C3HB6(F1) hybrid mice.

143 or T cells in a well-established parent-into-F1 hybrid model (C57BL/6J-->C3FeB6F1/J).

144 expression of several candidate RME genes in F1 hybrid mouse cells before and after differentiation,

145 F1 hybrid mouse embryos were subjected to three experime

146 ferentiation at single-cell resolution in an F1 hybrid mouse system, allowing for the comprehensive c

147 basis of heterosis, here we used a subset of F1 hybrids, named a partial North Carolina II design, to

148 ins of mice, such as A/J and (C57BL/6J x A/J)F1 hybrids, neonatal thymectomy-induced autoimmune ovari

149 on of polymorphisms in 129 F2 progeny of one F1 hybrid obtained by crossing two genetically divergent

150 uences for heterozygous samples including an F1 hybrid of Arabidopsis thaliana, the widely cultivated

151 An F1 hybrid of F344 and BN exhibited significant pituitary

152 ly germline-competent ES cell lines from the F1 hybrid of NOD and 129 for use in NOD gene targeting.

153 y admixed individuals, but sour orange is an F1 hybrid of pure C. maxima and C. reticulata parents, t

154 hat synthetic apomixis can be achieved in an F1 hybrid of rice by inducing MiMe mutations and egg cel

155 F1 hybrids of A x B have intermediate floral characters

156 F1 hybrids of both sexes mate frequently with both pure

157 m all of the other commonly used strains and F1 hybrids of C57BL/6 and BALB/c mice.

158 NA pathway function and TE regulation in the F1 hybrids of interspecific crosses between D. melanogas

159 Unlike other F1 hybrids of M. castaneus, these F1 mice were resistant

160 The F1 hybrids of New Zealand Black (NZB) and New Zealand Wh

161 F1 hybrids of New Zealand Black (NZB) and New Zealand Wh

162 F1 hybrids of New Zealand black (NZB) and New Zealand wh

163 to the development of autoimmune disease in F1 hybrids of New Zealand black (NZB) and white (NZW) mi

164 2 and CYP6A8 RNA levels were measured in the F1 hybrids of overproducer (91-R and MHIII-D23) and unde

165 In a separate experiment, F1 hybrids of SHRxBN strains and parental BN and SHR und

166 evelopment or progression of HIVAN by making F1 hybrids of TgFVB with five other inbred strains (CBA,

167 F1 hybrid offspring from 2 major PIA-susceptible strains

168 Analysis of (BALB/c x C57BL/6) F1 hybrid offspring indicates that PIR molecules bearing

169 tially methylated between the two alleles in F1 hybrid offspring, recapitulating the parental methyla

170 First filial (F1) hybrid offspring, which were gestated by B6 or cJ da

171 Reciprocal F1 hybrids permitted investigation of inheritance patter

172 erential chromosome pairing at meiosis in an F1 hybrid population, which indicates the importance of

173 their five matched controls and a set of 10 F1 hybrid populations derived from reciprocal crosses be

174 was also performed on similar tissues of the F1 hybrids produced by crossing B73 and each of the thre

175 esulting from reciprocal backcrosses between F1 hybrid progeny and C. nigoni or C. briggsae F2 hybrid

176 bred lines B73 and Mo17 and their reciprocal F1 hybrid progeny in primary roots under control and wat

177 he maize inbred lines B73 and Mo17 and their F1 hybrid progeny is reflected in differential, nonaddit

178 tion is now complete because of sterility of F1 hybrid progeny, prezygotic isolation is still incipie

179 four different primary root tissues of their F1-hybrid progeny.

180 Single-cell RNA-seq data from F1 hybrids provide a unique framework for dissecting com

181 ed phenotypic variation among the transgenic F1 hybrids, providing strong evidence for host genetic f

182 The Brown Norway/Fischer 344 F1 hybrid rats (F344BNF1) is a newer rat model and is em

183 uscle fibers from Fischer 344 x Brown Norway F1 hybrid rats of ages 5, 18, and 38 months through 1000

184 scle of 34-month-old Fisher 344/Brown Norway F1 hybrid rats, a well accepted animal model for biologi

185 aged (>22 months) Fisher 344 x Brown Norway F1 hybrid rats, compared to young (4-6 month) and middle

186 by PhIP in Sprague-Dawley (SD)xWistar Furth F1 hybrid rats.

187 nd aged (30 months) Fischer 344/Brown Norway F1 hybrid rats.

188 diac transplants between parental donors and F1 hybrid recipients to provide evidence that NK cells,

189 ponse genes are significantly altered in the F1 hybrids relative to the parental lines.

190 The F1 hybrids resembled one parent or the other, without sh

191 e of inbred allelic expression levels in the F1 hybrid, resulting in additive expression patterns.

192 s of two isogenic lines and their reciprocal F1 hybrids revealed 5820 genes as significantly differen

193 rents S. alterniflora and S. maritima, their F1 hybrid S. x townsendii and the allopolyploid S. angli

194 ies (S. alterniflora and S. maritima), their F1 hybrid S. x townsendii, and the neoallododecaploid S.

195 In flowering plants, F1 hybrid seed lethality is a common outcome of crosses

196 We found that F1 hybrid seed lethality is an exceptionally strong isol

197 Male sterility plays an important role in F1 hybrid seed production.

198 Phenotypically, the F1 hybrids show remarkable heterosis in silique number a

199 ession assays of Bmp6 in developing teeth in F1 hybrids show that cis-regulatory changes have elevate

200 The F1 hybrids showed an average percentage of intima interm

201 the changes in gene expression level in the F1 hybrids showed that the majority of the small interfe

202 F1 hybrid sterility and "hybrid breakdown" of F2 and lat

203 y represent a universal mechanistic basis of F1 hybrid sterility manifested by pachytene arrest.

204 ent species' genomes is not a major cause of F1 hybrid sterility, although it may contribute to repro

205 The 100% cis-regulation in F1 hybrids suggests the methylation machinery is conserv

206 DNase I for chromatin fragmentation to mouse F1 hybrid systems.

207 lusters had a higher expression level in the F1 hybrids than in the parents, and that there was an in

208 aspecific Arabidopsis (Arabidopsis thaliana) F1 hybrids that show different levels of heterosis at ma

209 on on survival or reproductive characters in F1-hybrids, these results suggest that introgression sho

210 th either C57BL/6J or DBA/2J wild-type mice, F1 hybrid Tmc1Bth/+ progeny have increased hearing loss

211 mined allele-specific expression (ASE) in an F1 hybrid to study how alleles from two Arabidopsis thal

212 2 mice from a backcross of (C57BL/6JxDBA/2J) F1 hybrids to DBA/2J mice confirmed this linkage (LOD>50

213 a backcross of (B6.CAST-Cdh23 Ahl+ xDBA/2J) F1 hybrids to DBA/2J mice demonstrated a genetic interac

214 ila with a range of divergence times and use F1 hybrids to examine inheritance patterns and disentang

215 by phasing the genomes of three interspecies F1 hybrids to generate near-gapless single-haplotype ass

216 ulations include inbred, recombinant inbred, F1 hybrid, transgenic, targeted mutants, chromosome subs

217 tion, we delete the core PRC2 protein EED in F1 hybrid trophoblast stem cells (TSCs), which undergo i

218 Surprisingly, the F1 hybrid tumors were not hemorrhagic and had hemoglobin

219 ly and were maintained when the fertility of F1 hybrids was high.

220 Lastly, by comparing reciprocal F1 hybrids, we identified evidence of imprinting in the

221 nt marine-freshwater ecotype pairs and their F1 hybrids, we show that cis-acting (allele-specific) re

222 allele-specific transcript abundance in the F1 hybrids, we were able to measure the abundance of cis

223 To follow segregation of hearing loss, F1 hybrids were backcrossed to the parental strains with

224 al amounts of CYP6A2 and CYP6A8 mRNAs in the F1 hybrids were lower than half the amounts of these RNA

225 Cardiac allografts from Lewis x Brown Norway F1 hybrids were rejected in 7+/-1 days in Lewis rats.

226 ed strains, wild species and subspecies, and F1 hybrids were studied using an unbiased electron micro

227 Since both male and female F1 hybrids were used to produce backcross progeny, these

228 n the Arabidopsis C24/Landsberg erecta (Ler) F1 hybrids, which show patterns of inheritance dependent

229 of the differentially expressed genes in the F1 hybrid with those of eight hybrid mimic lines identif

230 could revolutionize agriculture by allowing F1 hybrids with enhanced yield and stability to be clona

231 ssecting cis and trans effects is to compare F1 hybrids with F0 homozygotes.

232 tty/Spontaneously hypertensive heart failure F1 hybrid (ZSF1) rats.