ライフサイエンスコーパス: FGF

1 FGF 23, FMD and hsCRP can stratify the risk of early CVD

2 FGF and Hedgehog morphogen signals are required, with FG

3 FGF signaling has emerged as a significant "late-stage"

4 FGF signaling induces JNK-dependent proteasomal degradat

5 FGF signaling promotes epicardium formation in vivo, and

6 FGF signalling pathways are found to be flexible in arch

7 FGF signals are thus essential regulators of myotube gui

8 FGF-mediated PM induction in NMPs functions in tight coo

9 FGF/ERK signaling is crucial for the patterning and prol

10 FGFs are key developmental regulators that engage a sign

11 By examining the 5' UTRs of HIF-1alpha, FGF-9, and p53 mRNAs and using fluorescence anisotropy b

12 (2) (PGE(2)) and fibroblast growth factor 2 (FGF-2) -mediators known to influence fibroblast activati

13 ds to VEGF-A and fibroblast growth factor-2 (FGF-2) in human plasma and colocalizes with VEGF-A in EC

14 oncentrate (BMAC) and growth factors (BMP-2, FGF-2, and FGF-8) and 2) increase matrix strength retent

15 baseline, only fibroblast growth factor 21 (FGF-21) predicted weight loss, and none helped individua

16 rmone (PTH) and fibroblast growth factor 23 (FGF-23) were studied up to 24-hours after Npt2a-I treatm

17 alyses revealed lower group levels of FGF-5, FGF-19 and SPOCK1 in multiple system atrophy compared wi

18 ha [HIF-1alpha], fibroblast growth factor 9 [FGF-9], and p53) is still translated by an unknown, cap-

19 lage, as evidenced by the fact that aberrant FGF signalling contributes to the maldevelopment of join

20 f BRD4 decreased NRP1 expression and ablated FGF-mediated tumor cell growth.

21 Although ligands that activate FGF receptors have antidepressant and anxiolytic effects

22 ural cell adhesion molecule (NCAM) activates FGF receptors, we asked whether peripherally administere

23 ther revealed its initiation by 'activators' FGF and Wnt, and 'inhibitor' Hh, whereas BMP and mesench

24 PSCs can be recapitulated without affecting FGF-MEK signalling or global DNA methylation.

25 However, it remains unknown whether all FGF activities depend on this canonical signal transduct

26 in of 120 amino acids (aa) is flanked in all FGFs by highly divergent amino-terminal and carboxy-term

27 An FGF-Foxf pathway acts in multipotent progenitors to esta

28 its role in Wnt signaling, Rspo2 acts as an FGF antagonist during mesoderm formation and patterning.

29 d activating binary complexes composed of an FGF receptor (FGFR) bound to either alpha-Klotho or beta

30 contribute to mesoderm heterogeneity via an FGF receptor-dependent positive feedback mechanism.

31 sequenced the fin whale genome and analysed FGFs from 8 cetaceans.

32 GDF-15 and FGF-21 were measured in serum from 24 patients with TK2

33 lly, intraarticular treatment with FGF-2 and FGF-8 was found to suppress joint inflammation.

34 data identify CREB activation via PGE(2) and FGF-2 as a previously unrecognized molecular controller

35 (BMAC) and growth factors (BMP-2, FGF-2, and FGF-8) and 2) increase matrix strength retention.

36 ls were cultured and treated with VEGF A and FGF 2 and the mRNA expression pattern of EGR family memb

37 It was observed that VEGF A and FGF 2 induced angiogenesis, cell proliferation and stero

38 ole of EGR mediated regulation of VEGF A and FGF 2 signaling in buffalo luteal cells.

39 owever, their role in controlling VEGF A and FGF 2 signaling in the CL of water buffalo is not known.

40 then cultured and stimulated with VEGF A and FGF 2.

41 hough both PGE(2) (via protein kinase A) and FGF-2 (via protein kinase B, also known as AKT) depended

42 g, likely being involved in TGF-beta/BMP and FGF/EGF signaling pathways.

43 How Na(V) -CaM, CaMKII and FGF/fibroblast growth factor homologous factor interacti

44 ed the functional divergence between Etv and FGF in lens development, demonstrating that these SRTFs

45 vels of fibroblast growth factors (FGFs) and FGF receptors (FGFRs) have been detected in various neur

46 and increased circulating serum insulin and FGF-21 concentrations.

47 g complex composed of alpha-Klotho (KLA) and FGF receptor (FGFR) resulting in kinase activation, regu

48 vestigate the regulation of renal Klotho and FGF receptor (FEFR)-1 in healthy and uremic rats induced

49 Decreased circulating FGF-21 levels and FGF-21 message expression in the liver were found in Gpr

50 anscriptional patterning of the mesoderm and FGF signaling for mesoderm migration.

51 ective activation of PI3K and MAPK, PDGF and FGF cooperate with and oppose each other to balance prog

52 As expected retinoic acid (RA) and FGF are able to modulate HOX expression in the posterior

53 des evidence convincingly that both VEGF and FGF mediate their biological action through a common int

54 During Xenopus gastrulation, Wnt and FGF signaling pathways cooperate to induce posterior str

55 Wnt and FGF signaling promote the differentiation of these putat

56 hPSCs using sequential modulation of Wnt and FGF signaling to generate second heart field progenitors

57 as a key regulator that antagonizes WNT and FGF signaling to regulate MSC lineage commitment.

58 al stem cell (MSC) fate by mediating WNT and FGF signaling.

59 e absence of SPRY1, FGF9, and FGF20, another FGF ligand, FGF8, promotes nephrogenesis.

60 transcription factors modulated enhancers at FGF gene loci.

61 Here, we demonstrate that the autocrine FGF/FGFR axis is essential for multiple myeloma cell sur

62 eceptors 1-3, PDGF receptors alpha and beta, FGF receptors 1-3, and Src and Abl kinases, which are al

63 ors (serum, ascorbic acid, insulin, and beta-FGF) are examined to study their effects on the differen

64 trating the antagonistic interaction between FGF-induced MAPK and PDGF-induced PI3K signaling.

65 portant in organogenesis (Wnt, TGFbeta/ BMP, FGF, Notch, SHH, Erbb) were differentially expressed bet

66 ted changes in genes regulating TGF-beta/BMP/FGF signaling, as well as in genes controlling ECM struc

67 This is achieved by FGF-dependent control of c-MYC (MYC) expression that, in

68 get for cancer therapy, FGF/FGFR blockade by FGF trapping or tyrosine kinase inhibitor impaired the g

69 this pathway is activated in chondrocytes by FGF signaling, a critical regulator of skeletal growth.

70 n the epithelialisation timing controlled by FGF activity.

71 ands from the embryonic node and executed by FGF signals in nascent mesoderm to control anterior meso

72 nscription factor, ETV4, which is induced by FGF signalling and acts as a repressor of ZRS activity,

73 but inactive state of the ZRS is induced by FGF signalling and in combination with balanced histone

74 ion of inner ear progenitors is initiated by FGF signalling.

75 ersus 2.5 h), but are similarly regulated by FGF, WNT, Notch and YAP signalling(5).

76 calcium concentrations, activation of cAMP, FGF, and R-spondin signaling with inhibition of bone mor

77 Decreased circulating FGF-21 levels and FGF-21 message expression in the liver

78 The polydopamine-coated FGF-loaded PXDDA samples were then characterized using F

79 g of FGF19, FGF21 and FGF23 to their cognate FGF receptors (FGFRs).

80 as receptor ligands through their conserved FGF domain, but sequences outside this domain vary and a

81 ta-catenin, and that N-cadherin also dampens FGF activity and consequently stabilises neural fate.

82 Because FGF9 and FGF10 activate distinct FGF receptors (FGFRs), we hypothesized that they would c

83 neral mechanism for recognition of endocrine FGFs by Klotho proteins and regulatory interactions with

84 putative interactions between the endocrine FGFs and FGFR1/Klb, or FGF19 with FGFR4.

85 RNAseq) were used to investigate endogenous FGF expression profiles in these cultures over time.

86 FGFBP1 enhances FGF signaling including angiogenesis during cancer progr

87 he signaling mutations abrogated established FGF-induced signal transduction pathways, yet FGF functi

88 actor (FGF) signaling pathway, and exogenous FGF rescues the myogenic differentiation defects upon lo

89 Yet, TAMS not T cells express FGF receptors.

90 lls constitutively produce the growth factor FGF-2, which activates tumor-infiltrating B cells to pro

91 Levels of fibroblast growth factor (FGF) 1, FGF2, and FGF7 were significantly upregulated in

92 BA and fibroblast growth factor (FGF) 19 levels (a surrogate for intestinal farnesoid X r

93 cies, by measuring fibroblast growth factor (FGF) 19/15 protein and mRNA levels, and 7alpha-hydroxy-4

94 reduced C-terminal fibroblast growth factor (FGF) 23 compared with control.

95 regulating hormone fibroblast growth factor (FGF) 23 have emerged as powerful risk factors for cardio

96 relies on coupled fibroblast growth factor (FGF) and bone morphogenetic protein (BMP) signalling tog

97 Fibroblast Growth Factor (FGF) dependent signalling is frequently activated in can

98 For example, fibroblast growth factor (FGF) drives naive pluripotent cells into extraembryonic

99 s of the endocrine fibroblast growth factor (FGF) family designated FGF19, FGF21, and FGF23 mediate t

100 nce highlights the fibroblast growth factor (FGF) family in emotion modulation.

101 s of the endocrine-fibroblast growth factor (FGF) family, FGF19, 21, and 23 are circulating hormones

102 Here, we show that fibroblast growth factor (FGF) ligands FGF8, FGF17 and FGF18 are essential for thi

103 Fibroblast growth factor (FGF) plays a vital role in the repair and regeneration o

104 lly with canonical fibroblast growth factor (FGF) proteins that signal through the extracellular sign

105 ating mutations in fibroblast growth factor (FGF) receptor 3 and inactivating mutations in the NPR2 g

106 nents of endocrine fibroblast growth factor (FGF) receptor complexes, as they are required for the hi

107 activation of the fibroblast growth factor (FGF) receptor, phospholipase C (PLC), protein kinase C (

108 tral activation of fibroblast growth factor (FGF) receptors regulates peripheral glucose homeostasis

109 ne a Hedgehog (Hh)-fibroblast growth factor (FGF) signaling axis required for anterior mesoderm linea

110 The fibroblast growth factor (FGF) signaling cascade is a key signaling pathway in hep

111 nal attenuation of fibroblast growth factor (FGF) signaling is essential for the establishment of the

112 components of the Fibroblast Growth Factor (FGF) signaling pathway were enriched in nascent myotubes

113 is mediated by the fibroblast growth factor (FGF) signaling pathway, and exogenous FGF rescues the my

114 Fibroblast growth factor (FGF) signaling plays pivotal roles in generating and mai

115 Fibroblast Growth Factor (FGF) signaling promotes self-renewal in progenitor cells

116 ymes downstream of fibroblast growth factor (FGF) signaling.

117 oderm cells due to fibroblast growth factor (FGF) signaling.

118 Fibroblast growth factor (FGF) signalling in the distal limb primes the ZRS at ear

119 Regulated fibroblast growth factor (FGF) signalling is a prerequisite for the correct develo

120 beta (TGFbeta) and fibroblast growth factor (FGF) signalling pathways to co-induce cranial epithelial

121 in the absence of fibroblast growth factor (FGF) signalling.

122 f an intracellular fibroblast growth factor (FGF), FGF13, in the mouse DRG neurons selectively abolis

123 ere, by modulating fibroblast growth factor (FGF), transforming growth factor beta (TGF-beta), and WN

124 fying a network of fibroblast growth factor (FGF), wingless-related integration site (WNT), and bone

125 uld be enhanced by fibroblast growth factor (FGF)1 or FGF2.

126 Fibroblast growth factor (FGF)13, a nonsecreted, X-linked, FGF homologous factor,

127 and that required fibroblast growth factor (FGF)19 signaling via FGF receptor 4 for survival were mo

128 aily injections of fibroblast growth factor (FGF)19.

129 ts, mean levels of hepatocyte growth factor, FGF-13, and IGF-1, but not FGF-2, were significantly hig

130 Fibroblast growth factors (FGF) act as proangiogenic and mitogenic cytokines in mul

131 proteins (such as fibroblast growth factors (FGF) or CaM-dependent kinase II (CaMKII)) that can also

132 , we identify two fibroblast growth factors (FGF), FGF6 and FGF9, as potent inducers of UCP1 expressi

133 Fibroblast growth factors (FGFs) 21 and 23 are recently identified hormones regulat

134 Fibroblast growth factors (FGFs) 9 and 10 are essential during the pseudoglandular

135 bnormal levels of fibroblast growth factors (FGFs) and FGF receptors (FGFRs) have been detected in va

136 by the supply of fibroblast growth factors (FGFs) from lymphatic endothelial cells.

137 Most fibroblast growth factors (FGFs) function as receptor ligands through their conserv

138 demonstrate that fibroblast growth factors (FGFs) position the pineal progenitor domain within the n

139 te growth factor, fibroblast growth factors (FGFs)-2 and -13, and type 1 insulin-like growth factor (

140 Drosophila has fewer FGF genes, with only three identified to date, pyramus (

141 rthermore, genetic overexpression of the fly FGF branchless (bnl) in the tubules induces expression o

142 Flow-mediated dilatation (FMD), FGF-23, serum lipid, hsCRP levels, BMI and HOMA were ass

143 formation, which suggest a crucial role for FGF in survival/proliferation, and a requirement of BMP

144 Strategies for FGF signalling-based treatment of osteoarthritis and for

145 DESIGN, SETTING, AND PARTICIPANTS: FORWARD (FGF-18 Osteoarthritis Randomized Trial with Administrati

146 Of the four FGF receptors (FGFRs 1-4), FGFR1 and FGFR3 are strongly

147 ion in the paracrine activation of Heartless FGF receptor.

148 The Heartless FGF receptor acts cell-autonomously in ensheathing glia

149 chment in canonical pathways included HIF1A, FGF/stemness, WNT signaling, interferon signaling and co

150 imposing this prepattern's condition of high FGF and low BMP activity across the entire skin reveals

151 We report high FGF receptor (FGFR) expression in 17.7% (11 of 62) of he

152 after meal; for example insulin-like hormone FGF-19 levels were elevated at 240 min (p = 0.001).

153 How FGF activity is restricted to leading cells in this syst

154 mics approach, SILAC, is applied to identify FGF-regulated phosphorylation events in two triple- nega

155 Here we identify FGF receptor (FGFR) signalling as a critical regulator o

156 g up the risk of aberrant differentiation if FGF is activated before Nodal.

157 ased activation of the MAP kinases ERK1/2 in FGF-2-stimulated cell lines of affected individuals that

158 Focal adhesions in FGF-2-stimulated fibroblasts of affected individuals con

159 be hijacked by disease-causing mutations in FGF receptor (FGFR) during embryogenesis.

160 re, we describe a novel function of Rspo2 in FGF pathway regulation in vivo Overexpressed Rspo2 inhib

161 Decreasing or increasing FGF signaling in a Notch loss-of-function context respec

162 on phenotype by pharmacologically inhibiting FGF signaling shows that the normal role of Hs2st is to

163 ism independent of adipogenesis and involves FGF receptor-3 (FGFR3), prostaglandin-E2 and interaction

164 actor-extracellular signal-regulated kinase (FGF -ERK) signalling drives differentiation of mouse emb

165 nl), and all three encoding relatively large FGF proteins (~80 kDa).

166 wth factor (FGF)13, a nonsecreted, X-linked, FGF homologous factor, is differentially expressed in ad

167 sed a simple dopamine coating method to load FGF on the surface of PXDDA polymeric films.

168 litol dodecanedioic acid) (PXDDA) and loaded FGF on the PXDDA for sustained drug delivery.

169 We hypothesized that the longer FGF proteins present in Drosophila and other organisms m

170 lved in PDGF, EGFR, VEGF, insulin/IGF/MAPKK, FGF, Hedgehog, TGFbeta, and PI3K signaling pathways.

171 nstrate that, during normal lung maturation, FGF signaling restricts expression of the elastogenic ma

172 lectivity in their requirement for mediating FGF receptor (FGFR) signaling and activating downstream

173 hanism that prepares Drosophila melanogaster FGF Branchless (Bnl) for cytoneme-mediated intercellular

174 t the embryonic mouse telencephalic midline, FGF/ERK signaling drives astroglial precursor somal tran

175 ant and anxiolytic effects in animal models, FGF ligands have a broad range of actions both in the br

176 n mice to understand whether SPRY1 modulates FGF signaling in NPCs and whether FGF8 functions with FG

177 As heparan sulfate modulates FGF-mediated signaling, we found a significantly decreas

178 ss the role of Notch signaling in modulating FGF activity within the parapineal.

179 with other FGF/FGFR alterations, 18 with no FGF/FGFR alterations, and one with an undetermined FGF/F

180 er FGF/FGFR alterations, or patients with no FGF/FGFR alterations.

181 te growth factor, FGF-13, and IGF-1, but not FGF-2, were significantly higher by up to 7-fold than in

182 A decrease in HK2 levels in the absence of FGF signalling inputs results in decreased glycolysis, l

183 corresponded with constitutive activation of FGF receptor 4 (FGFR4)-dependent ERK/AKT-p70S6K-S6 signa

184 expressed in NPCs modulates the activity of FGF signaling and regulates NPC stemness.

185 higher species under the hormonal control of FGF-signaling.

186 The decline of FGF-21 was less prominent and consistent.

187 kinase-ERK signal transduction downstream of FGF receptor activation.

188 brane tension facilitates the endocytosis of FGF signaling components, which activate ERK signaling a

189 SUM52, that exhibit amplified expression of FGF receptor 2 (FGFR2) and are dependent on continued FG

190 Here, we examined a family of FGF-induced SRTFs - Etv1, Etv 4, and Etv 5 - in murine l

191 The functions of FGF receptors (FGFRs) in early development of the cerebr

192 he PXDDA film enhanced the immobilization of FGF and controlled its sustained release.

193 The potent impact of FGF-FGFR in multiple embryonic developmental processes m

194 The observed inhibition of FGF signaling was accompanied by the downregulation of t

195 This study expands the known landscape of FGF signalling and identifies many new targets for funct

196 ific analyses revealed lower group levels of FGF-5, FGF-19 and SPOCK1 in multiple system atrophy comp

197 Manipulation of FGF or Wnt signaling demonstrated that 'ring' genes are

198 Modulation of FGF signaling achieves stratified squamous epithelium fr

199 k new avenues for discovery of modulators of FGF signalling that can slow or stop the progression of

200 Mutation of FGF receptor Heartless (Htl) has been shown to cause CVM

201 The in vitro drug release profile of FGF from PXDDA film and cell growth behavior were measur

202 ere TIMPs negatively regulate the release of FGF-2 from chondrocytes to allow IHH expression.

203 l as regulates the production and release of FGF-21 to control systemic energy homeostasis.

204 served discrepancies relating to the role of FGF/ERK signalling in PrE versus EPI specification betwe

205 The inductive roles of FGF, Wnt, and BMP at the neural plate border are well es

206 ; investigation of the crystal structures of FGF-Klotho-FGFR complexes is paving the way for the deve

207 rescues the defects caused by suppression of FGF signalling.

208 that CDC42 is involved in the trafficking of FGF receptors to the cell membrane to regulate epicardiu

209 An improved understanding of FGF signalling from a structural biology perspective, an

210 through competition for a limited supply of FGFs.

211 ntitative dependence of stem cell density on FGF dosage, the biased localization of stem cells toward

212 e demonstrate a selective action of Hs2st on FGF protein by showing that Hs2st (but not Hs6st1) norma

213 oblast cells attachment and proliferation on FGF-immobilized PXDDA films were much higher than the ot

214 high affinity ligand for FGFR3, is the only FGF-based drug currently in clinical trials for osteoart

215 er than the other groups without coatings or FGF loading.

216 ty and mechanism of action of FGF2 and other FGF family members, as well as neurotrophic and differen

217 FR2 fusions or rearrangements, 20 with other FGF/FGFR alterations, 18 with no FGF/FGFR alterations, a

218 sions or rearrangements, patients with other FGF/FGFR alterations, or patients with no FGF/FGFR alter

219 Our results suggest that other FGFs may be membrane tethered or multifunctional like Py

220 Paracrine FGF-ERK signalling induces heterogeneity, whereby cells

221 r effects appear to be mediated by paracrine FGF control of kidney FGFR1 and subsequent regulation of

222 Unlike the heparin-binding paracrine FGFs, eFGFs require a unique Klotho family protein to fo

223 l distribution and levels of this particular FGF protein are tightly regulated.

224 llular differentiation stimuli, particularly FGF-MEK signalling.

225 on multiple previously implicated pathways: FGF, Hh, Wnt and BMP.

226 ction experiments that the epiblast provides FGF signal that results in differential fate acquisition

227 or intra-DMS blockade of the FGF2 receptor, FGF receptor-1 (FGFR1), suppresses alcohol consumption,

228 med a small screen that revealed how reduced FGF signalling induces a short-tail phenotype in embryos

229 ression suggests that functionally redundant FGF ligands may contribute to vestibular hair cell diffe

230 ng of the molecular mechanisms that regulate FGF signalling during normal joint development and in th

231 ine astroglial development and in regulating FGF protein levels and interaction with HS.

232 le is known about the molecule(s) regulating FGF signaling during nephron development.

233 the inner cell mass (ICM), all cells relayed FGF/ERK signals with varying durations and magnitude.

234 t the nascent PR axon, which in turn release FGF to induce SGs' differentiation into WG.

235 ompanied by Erk phosphorylation and required FGF and Nodal but not Wnt signaling.

236 tors within the mammalian lower jaw requires FGF signaling.

237 alateral merging are attenuated by restoring FGF signaling specifically in the CVM, suggesting that m

238 parapineal through its capacity to restrict FGF pathway activation to a few leading cells.

239 Furthermore, these same FGFs were downregulated over time in (R200Q)VSX2 hiPSC-O

240 tures were treated exogenously with selected FGFs and subjected to gene and protein expression analys

241 We found that some FGFs - including FGF2, strongly increased GLT1 expressio

242 tor' Hh, whereas BMP and mesenchyme-specific-FGF signalling were incorporated once stripes were forme

243 rphogenesis; however, the inverse, supplying FGF to the TVM, does not rescue CVM mismigration.

244 that the normal role of Hs2st is to suppress FGF-mediated astroglial translocation.

245 Id1 then suppresses FGF activity to delay differentiation.

246 our data suggest a model in which sustained FGF signaling acts to suppress cardiomyocyte plasticity

247 Furthermore, we demonstrate that FGF signalling controls the phase and period of oscillat

248 l and disease progression, and indicate that FGF targeting may represent a therapeutic approach for p

249 Our results indicate that FGF/MAPK blockade may be particularly efficacious agains

250 In addition, we show that FGF regulates integrin expression in both tissues, but o

251 We show that FGF-MAPK signalling maintains multipotency and promotes

252 Our work shows that FGF signaling directs zonal patterning at the boundary b

253 The FGF inhibitory activity was mapped to the thrombospondin

254 The FGF ligand Pyramus is expressed broadly in the ectoderm,

255 ed number of parapineal cells activating the FGF pathway, global activation of Notch signaling decrea

256 fied by secreted signaling proteins from the FGF, Nodal, BMP and Wnt families.

257 Null mutations in the FGF receptor heartless (htl), or its ligands, caused sig

258 network by which activating mutations in the FGF receptor inhibit bone growth.

259 eptor tyrosine kinases (RTKs), including the FGF receptor, are TRIAD1 substrates that are possibly re

260 y, we described that focal activation of the FGF pathway promotes the migration of the parapineal in

261 targets of Pnhd are shared with those of the FGF pathway.

262 Inhibitors of the FGF receptor (Fgfr) and ERK pathways reversed the skewed

263 miRNAs collectively target components of the FGF signaling pathway, a central player in the process o

264 was accompanied by the downregulation of the FGF target genes tbxt/brachyury and cdx4, which mediate

265 Aberrant signaling of the FGF/FGFR pathway occurs frequently in cancers and is an

266 ge priming is prevented by inhibition of the FGF/MAPK signalling pathway.

267 Therefore, targeting the FGF-Klotho endocrine axes might have therapeutic benefit

268 ng ChIP-seq, we show, surprisingly, that the FGF signaling mediator Ets2 binds near all Wnt target ge

269 Growing evidence suggests that the FGF-Klotho endocrine system also has a crucial role in t

270 findings dissect the mechanism by which the FGF/FGFR system plays a nonredundant role in multiple my

271 x status can be a target for cancer therapy, FGF/FGFR blockade by FGF trapping or tyrosine kinase inh

272 rs promote pinealogenesis by inhibiting this FGF activity.

273 Thus FGF signaling lowers cyclic GMP production in the growth

274 Thus, FGF-dependent regulation of endothelial glycolysis is a

275 We identify TIMP/FGF-2/IHH as a novel nexus underlying bone lengthening w

276 Contrary to FGF receptor mutants that displayed loss of ERK signalin

277 n and rescue the proapoptotic effects due to FGF blockade.

278 kinase 2 (TK2) deficiency and compared it to FGF-21.

279 ranscription factor NF-kappaB in response to FGF and IL-1/TNF, respectively.

280 ubcellular branching as a direct response to FGF signalling.

281 explants and Erk1 activation in response to FGF.

282 nstrated that 'ring' genes are responsive to FGF signaling at the dorsal midline, whereas 'horseshoe'

283 This PDX model is highly sensitive to FGF receptor (FGFR) inhibition, and more so to combined

284 al were more sensitive to trametinib than to FGF receptor 4 inhibitors.

285 the biased localization of stem cells toward FGF sources, and stem cell dynamics during regeneration

286 Pyr is the first demonstrated transmembrane FGF, that it has both extracellular and intracellular fu

287 FR alterations, and one with an undetermined FGF/FGFR alteration.

288 s elegans Dicer1 is also phosphorylated upon FGF stimulation at conserved serines in mouse embryonic

289 -beta increased KL secretion and upregulated FGF receptor (FGFR) 1.

290 homeostasis and eating/drinking behavior via FGF receptor 1/Klothobeta (FGFR1/KLB) complexes expresse

291 broblast growth factor (FGF)19 signaling via FGF receptor 4 for survival were more sensitive to trame

292 ween BMP target genes largely collapsed when FGF and Nodal signaling were inhibited.

293 Wnt signaling initiates EMT, whereas FGF signaling terminates this event.

294 es new insights into the mechanisms by which FGF antagonists promote multiple myeloma cell death.

295 se results identify mechanisms through which FGF signaling regulates inner cell mass lineage restrict

296 ogether, these data support a model in which FGFs, possibly from axons, activate FGFR2 in the oligode

297 edgehog morphogen signals are required, with FGF providing a directional cue.

298 Additionally, intraarticular treatment with FGF-2 and FGF-8 was found to suppress joint inflammation

299 Furthermore, treatment with FGFs provides a robust means for expansion of functional

300 GF-induced signal transduction pathways, yet FGF functions such as cell-matrix and cell-cell adhesion