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1 Freund's complete adjuvant were used to induce joint inf
2 Freund's incomplete adjuvant (FIA) is one such example t
3 adjuvants: alum, Freund's complete adjuvant, Freund's incomplete adjuvant, and monophosphoryl-lipid A
4 tigen given in four typical adjuvants: alum, Freund's complete adjuvant, Freund's incomplete adjuvant
5 s in immunogenic formulations based on alum, Freund's adjuvant, or two different types of liposomes.
6 ent studies in Cell by Joachimiak et al. and Freund et al., a new class of TRiC substrate is identifi
10 by 6 wk after a challenge with human GAA and Freund's adjuvant; in contrast, administration of the AA
11 n were noted, for dams immunized with gB and Freund's adjuvant, compared with dams immunized with gB
12 oPn) major outer membrane protein (MOMP) and Freund's adjuvant can protect mice against a genital cha
13 abbits that were mock immunized with PBS and Freund's adjuvant or with PPSV23 and Freund's adjuvant a
14 e conserved protein virulence factor PLY and Freund's adjuvant is able to reduce corneal inflammation
15 ith pneumococcal capsular polysaccharide and Freund's adjuvant fails to produce opsonizing antibodies
16 PBS and Freund's adjuvant or with PPSV23 and Freund's adjuvant at 48 hours after infection (P </= 0.0
17 ), whereas rabbits immunized with PPSV23 and Freund's adjuvant failed to show differences in clinical
19 eas of the rabbits immunized with psiPLY and Freund's adjuvant were significantly lower than scores o
21 oved for use in humans, was as protective as Freund's Adjuvant, and protective vaccination correlated
25 weeks of age using type II chicken collagen, Freund's complete adjuvant, and, on occasion, a lipopoly
28 ates inflammatory hyperalgesia in a complete Freund's adjuvant (CFA)-induced inflammatory pain rat mo
29 bazone) ((64)Cu-PTSM) at 24 h after complete Freund adjuvant injection using a small-animal PET devic
31 injection of an inflammatory agent, complete Freund's adjuvant, into the masseter muscle and perfused
32 ted in the K/BxN serum-transfer and complete Freund's adjuvant (CFA)-evoked active immunization model
33 (8-60 min), carrageenan (3 hr), and complete Freund's adjuvant (CFA; 3 d) into the rat hindpaw as wel
34 injection of donor splenocytes and complete Freund's adjuvant eliminates autoimmunity and permanentl
35 , and immunization with antigen and complete Freund's adjuvant induced interferon-gamma-secreting, an
36 with soluble B. malayi antigen and complete Freund's adjuvant resulted in significantly fewer IL-4-p
38 DO11.10) along with OVA peptide and complete Freund's adjuvant, observing a dramatic increase in OVA-
39 inflammatory stimuli, formalin and complete Freund's adjuvant, were reduced or abolished in AC1&8 DK
44 inducing liver histologic change as complete Freund's adjuvant (CFA), the standard adjuvant used for
47 alin-induced spontaneous behaviors, complete Freund's adjuvant-induced heat and mechanical hypersensi
48 persistent inflammation induced by complete Freund's adjuvant (CFA) increased GABAergic miniature IP
49 ng hindlimb inflammation induced by complete Freund's adjuvant (CFA) injections in the hindpaw and hi
50 persistent inflammation induced by Complete Freund's adjuvant (CFA) modulates GABA signaling differe
51 hed mechanical allodynia induced by complete Freund's adjuvant (CFA) or by partial sciatic nerve liga
53 211 suppressed allodynia induced by complete Freund's adjuvant and the chemotherapeutic agent paclita
56 sed thermal hyperalgesia induced by complete Freund's adjuvant injection and reduced response to acid
57 mechanical hyperalgesia induced by complete Freund's adjuvant was accompanied by C5a upregulation an
58 -inducing chromic gut; and (4) CFA (complete Freund's adjuvant), intradermal complete Freund's adjuva
59 agonist of TRPA1) and reversed CFA (Complete Freund's Adjuvant)-induced inflammation and thermal hype
61 f the mTOR signaling pathway during complete Freund's adjuvant (CFA)-induced chronic inflammatory pai
62 PD) mRNA than did the adults during complete Freund's adjuvant (CFA)-induced peripheral inflammation.
63 e phase inflammatory pain following complete Freund's adjuvant injection and the late phase neuropath
67 by injection of collagen type II in complete Freund adjuvant, and cell suspensions from the inflamed
71 with Arg(12) mutant ras peptide in complete Freund's adjuvant (CFA) develop T cells within 10 d that
72 th a uveitogenic regimen of IRBP in complete Freund's adjuvant (CFA) exhibited CD25+ regulatory cells
73 ed with a single dose of vaccine in complete Freund's adjuvant (CFA) generated antigen-specific gamma
74 more efficient than free peptide in complete Freund's adjuvant (CFA) in inducing T cell activation an
75 low-pathology BL/6 mice with SEA in complete Freund's adjuvant (CFA) once before, and once again duri
76 myelin basic protein emulsified in complete Freund's adjuvant (CFA) or passively by the transfer of
77 s the protective response, CneF, in complete Freund's adjuvant (CFA) or the immunogen that induces th
78 rough preinjection with beta-gal in complete Freund's adjuvant (CFA) or through preinjection with sol
79 face adhesin A (PsaA) emulsified in complete Freund's adjuvant (CFA) provides protection against syst
80 to the epitope peptide delivered in complete Freund's adjuvant (CFA), and IgM production was even gre
81 g protein1-20 peptide (IRBP1-20) in complete Freund's adjuvant (CFA), with or without a preceding ATR
87 onferred by yMSP1(19) emulsified in complete Freund's adjuvant (CFA/incomplete Freund's adjuvant).
89 ntradermal injections of gliadin in complete Freund's adjuvant (immunization) or of soluble gliadin o
90 h schistosome egg antigens (SEA) in complete Freund's adjuvant (SEA/CFA) correlates with elevated pro
91 (HLA-A-like) peptides emulsified in complete Freund's adjuvant 7 d before transplantation (n = 5 to 7
92 rived protein extract emulsified in complete Freund's adjuvant and found that these mice developed ca
93 n A/J mice immunized with myosin in complete Freund's adjuvant in that myosin-specific antibodies and
94 ice with myocarditogenic peptide in complete Freund's adjuvant induced the infiltration of IL-17A-pro
95 bovine collagen (CII) emulsified in complete Freund's adjuvant inhibited T helper type 1 differentiat
96 57BL/6 mice with murine vimentin in complete Freund's adjuvant resulted in anti-vimentin antibodies a
97 eceptor retinoid-binding protein in complete Freund's adjuvant to test their efficacy in suppressing
100 pes when injected subcutaneously in complete Freund's adjuvant was significantly enhanced if administ
102 on with schistosome egg antigens in complete Freund's adjuvant, coinfection with the nematodes also r
103 odendrocyte glycoprotein peptide in complete Freund's adjuvant, correlating with milder experimental
104 When WEB2170 was added to OVA in complete Freund's adjuvant, enhanced IgG2a but not IgG1 productio
105 ection and not when administered in complete Freund's adjuvant, indicating that molecular mimicry-ind
106 allenged with antigen emulsified in complete Freund's adjuvant, the overall pattern was similar, exce
107 pain models, we found no change in Complete Freund's adjuvant-induced thermal or mechanical hypersen
119 ng this model, induced by injecting complete Freund's adjuvant (CFA) into one hind paw, we systematic
120 induced by subcutaneously injecting complete Freund's adjuvant (CFA) into the hind paws of rats.
121 atory pain was induced by injecting complete Freund's adjuvant subcutaneously into one hind paw of ra
122 etermined, using the intraarticular complete Freund adjuvant arthritis mice model, whether the radiot
123 ete Freund's adjuvant), intradermal complete Freund's adjuvant-induced hindlimb inflammation 1 and 4
124 ipheral inflammation (intraplanatar complete Freund's adjuvant) is substantially diminished in the nu
125 mal hyperalgesia after intraplantar complete Freund's adjuvant injection (ED(50) = 41 mg/kg, i.p.).
128 pain: (i) intraplantar injection of complete Freund's adjuvant (CFA) as a model of adjuvant- and path
134 nduced by a unilateral injection of complete Freund's adjuvant (CFA) into the masseter muscle under m
136 Hindpaw intraplantar injection of complete Freund's adjuvant (CFA) produced peripheral inflammation
137 mined the relative contributions of complete Freund's adjuvant (CFA)-induced inflammatory pain and op
141 ion induced by hindpaw injection of complete Freund's adjuvant (CFA): artemin expression increased 10
145 nduced by subcutaneous injection of Complete Freund's Adjuvant in the left hind paw of Sprague-Dawley
146 mation was produced by injection of complete Freund's adjuvant into one hindpaw in rats, and neurons
148 nd paw swelling to paw injection of complete Freund's adjuvant, a model of peripheral inflammatory pa
149 pheral nerve injury or injection of Complete Freund's Adjuvant, although they display intact nocicept
150 rculosis, an essential component of complete Freund's adjuvant, converted CD11b(hi)CD11c(-) monocytes
154 jection of formalin, carrageenan or complete Freund's adjuvant (CFA), without affecting basal pain pe
155 njection of capsaicin, formalin, or complete Freund's adjuvant more effectively than unconjugated CGR
160 toreceptor retinoid-binding protein/complete Freund's adjuvant (IRBP/CFA) or adoptive transfer of T c
163 d dose-dependently potently reduced complete Freund's adjuvant (CFA) induced chronic inflammatory pai
164 use formalin assay and also reduced complete Freund's adjuvant (CFA)-induced thermal hyperalgesia and
165 The 3d mutation slightly reduced complete Freund's adjuvant (CFA)-mediated antigen presentation, b
166 (ED50 = 30 micromolkg s.c.) reduced complete Freund's adjuvant-induced thermal hyperalgesia in the ra
170 ced thermal hypersensitivity in the complete Freund's adjuvant (CFA) model of inflammatory pain (1.3-
172 of sera from immunized mice in the complete Freund's adjuvant and Montanide ISA51 groups and after a
173 Several agonists were active in the complete Freund's adjuvant model of chronic inflammatory thermal
174 in the tail immersion assay, in the complete Freund's adjuvant model of inflammatory pain and in the
178 ore potent than that obtained using Complete Freund's Adjuvant with gp100, whereas no response was ob
179 nalysis of allografts from vimentin/complete Freund's adjuvant mice demonstrated increased numbers of
180 rom donor hearts placed in vimentin/complete Freund's adjuvant recipients contained anti-vimentin ant
181 used a model of arthritis in which complete Freund's adjuvant (CFA) was injected into the rat ankle
183 h S-antigen (S-Ag), emulsified with complete Freund adjuvant, and treated simultaneously with killed
185 C harvested from mice injected with complete Freund's adjuvant (CFA) enhanced type-1 cytokine respons
186 rats were injected bilaterally with complete Freund's adjuvant (CFA) into the TMJ or served as uninje
189 usly injection of (1) GA mixed with complete Freund's adjuvant (CFA), (2) CFA alone, or (3) saline.
191 cord slices from rats injected with complete Freund's adjuvant in one hindpaw and from uninflamed con
193 albumin with alum or ovalbumin with complete Freund's adjuvant to induce T helper type 2 or T helper
194 se models require immunization with complete Freund's adjuvant, whereas others suggest that a decreas
195 were immunized with IRBP mixed with complete Freund's adjuvant; eyes were enucleated on day 7 after i
196 isolated from rats with or without complete Freund's adjuvant (CFA) hindpaw inflammation, in respons
199 livered singly or in combination with either Freund's adjuvant or alum, indicated that augmented bact
202 (NZB x NZW)F1 mice were treated with either Freund's incomplete adjuvant (IFA) or phosphate buffered
203 nflammatory agent (carrageenan; CARR or FCA; Freund's complete adjuvant) or nerve injury (axotomy; AX
206 f nonhuman primates with E. coli MSP1(42) in Freund's adjuvant protected six of seven Aotus monkeys f
207 with trinitrophenyl-bovine serum albumin in Freund's complete adjuvant were significantly inhibited
208 experiment, mice were immunized with CII in Freund's complete adjuvant (CFA) and treated with a sing
212 ng DBA/1 mice with type II collagen (CII) in Freund's complete adjuvant, followed 3 weeks later by CI
213 emulsion of bovine type II collagen (CII) in Freund's incomplete adjuvant at the base of the tail.
214 e were immunized with cardiac myosin (CM) in Freund's adjuvant and received heterotopic, minor antige
215 re immunized with murine type II collagen in Freund's complete adjuvant, resulting in a chronic relap
217 n be achieved when MSP1(19) is emulsified in Freund adjuvant but not when it is adsorbed to aluminum
218 h purified recombinant LppQ-N' formulated in Freund's adjuvant and challenged them with M. mycoides s
219 vaccines, we tested gD2 in alum/MPL, gD2 in Freund's adjuvant, and dl5-29 (a replication-defective H
220 nized and boosted with a GABHS homogenate in Freund's adjuvant, whereas controls received Freund's ad
222 d groups of rabbits (n = 7) with each MAP in Freund's adjuvant and then exposed all rabbits to a 200-
223 of methylated bovine serum albumin (mBSA) in Freund's complete adjuvant and then challenged on day 21
225 rimmune sera of rabbits immunized with PA in Freund's adjuvant, with peak neutralization titers 23-,
227 x rabbits vaccinated with the MAP peptide in Freund's adjuvant developed high-titer, high-avidity ant
233 us CpG 1826, 0 of 4 (0%) with CFA/incomplete Freund's adjuvant, 0 of 4 (0%) with CpG 1826 mixed with
234 g oligodeoxynucleotides (CpGs) in incomplete Freund adjuvant and treated the mice with systemic inter
235 ccine administered to neonates in incomplete Freund's adjuvant (IFA) induced such cells in reduced nu
236 BP KO mice immunized with IRBP in incomplete Freund's adjuvant (IFA), lacking mycobacteria (whereas t
237 Treatment with E2 peptide2 in incomplete Freund's adjuvant (IFA), resulted in higher antibody pro
239 ed with gp100 melanoma peptide in incomplete Freund's adjuvant (peptide/IFA), which is commonly used
242 istration of the B9-23 peptide in incomplete Freund's adjuvant enhanced their insulin autoantibody re
243 e fragments of target antigens in incomplete Freund's adjuvant has resulted in severe anaphylactic re
244 a high dose of HEL emulsified in incomplete Freund's adjuvant, a strong splenic proliferative respon
245 in saline or intraperitoneally in incomplete Freund's adjuvant, with large quantities of the immunodo
249 esence or absence of LT(R192G) or incomplete Freund's adjuvant were not protected against lethal chal
251 num hydroxide, calcium phosphate, incomplete Freund's adjuvant, and the oil-in-water emulsion MF59.
252 dose) or gp100:209-217(210M) plus incomplete Freund's adjuvant (Montanide ISA-51) once per cycle, fol
254 , inactivated and formulated with incomplete Freund adjuvant, was administered intramuscularly every
258 mulated as a stable emulsion with incomplete Freund's adjuvant (Montanide ISA 51; Seppic SA, Paris, F
259 tion with ESO(157-170) mixed with incomplete Freund's adjuvant (Montanide ISA51) in 18 HLA-DP4+ EOC p
262 o the induction of arthritis with incomplete Freund's adjuvant, with similar effects in arthritis ind
264 serum from animals immunized with the nHgbAI/Freund's vaccine; however, anti-nHgbAI from both studies
265 ower antibody ELISA activity than the nHgbAI/Freund's, the nHgbAI/MPL vaccine provided protection aga
266 itic knee joint was produced by injection of Freund's complete adjuvant (CFA) into the knee joint of
270 the NOD mouse model by coupling injection of Freund's complete adjuvant with infusion of allogeneic s
273 however, detected in pristane-induced and/or Freund's incomplete adjuvant oil-induced arthritis.
274 ene expression in mice receiving formalin or Freund's complete adjuvant (CFA) as an inflammatory stim
275 9)-specific antibody production 12-fold over Freund adjuvant given i.p., 3-fold over Freund adjuvant
276 over Freund adjuvant given i.p., 3-fold over Freund adjuvant given subcutaneously (s.c.), 300-fold ov
277 h, once immediately post- and again 2 h post-Freund's adjuvant at GB 30, at the junction of the later
280 ral Brain Prize 2011 to Peter Somogyi, Tamas Freund and Gyorgy Buzsaki 'for their wide-ranging, techn
283 search for an adjuvant that is comparable to Freund's adjuvant in potency and is safe for use in huma
285 train 35000HP (nHgbAI) and administered with Freund's adjuvant provided complete protection against a
286 These two antigens were each emulsified with Freund's adjuvant and used to vaccinate Aotus nancymai m
287 human type II collagen (CII) emulsified with Freund's complete adjuvant (CFA), and compared with PGIA
289 inated either with yMSP1(19) formulated with Freund adjuvant, with alum, or with ODN plus alum and ch
291 islet transplantation and immunization with Freund's complete adjuvant along with multiple injection
292 d White rabbits were actively immunized with Freund's adjuvant mixed with pneumolysin toxoid (psiPLY)
293 e experiment, Lewis rats were immunized with Freund's complete adjuvant followed by administration of
294 BALB/cJ and MRL/MpJ mice were immunized with Freund's complete adjuvant in the presence or absence of
300 We previously reported that vaccination with Freund's adjuvant plus the recombinant N-terminus of the