ライフサイエンスコーパス: G-protein-coupled receptor kinase

1 n and the carboxyl-terminal region of bovine G-protein-coupled receptor kinase).

2 onist stimulation and phosphorylation by the G protein-coupled receptor kinases.

3 ion, and provide membrane contact points for G protein-coupled receptor kinases.

4 lated by protein kinase C (PKC) and P2Y12 by G protein-coupled receptor kinases.

5 the search for molecules that interact with G-protein-coupled receptor kinases.

6 Here, we provide evidence that G protein-coupled receptor kinase 1 (GPRK1), which is mo

7 RK, also known as G protein-coupled receptor kinase 1 (GRK1), is a compone

8 phosphorylation of its carboxyl terminus by G protein-coupled receptor kinase 1 (GRK1).

9 Phosphorylation of rhodopsin by G protein-coupled receptor kinase 1 (GRK1, or rhodopsin

10 gamma-subunits), cone phosphodiesterase, and G protein-coupled receptor kinase 1, whereas cone pigmen

11 Prenylated PDE6 subunits and G-protein coupled receptor kinase 1 (GRK1) were unable t

12 - and S-opsins), cone transducin (Galphat2), G-protein-coupled receptor kinase 1 (GRK1) and guanylate

13 off by phosphorylation by rhodopsin kinase [G-protein-coupled receptor kinase 1 (GRK1)] and subseque

14 (-/-)) mice and double-knockout mice lacking G-protein-coupled receptor kinase 1 (Nrl(-/-)Grk1(-/-)).

15 hodiesterase 6alpha' (PDE6alpha'), and GRK1 (G-protein-coupled receptor kinase 1; opsin kinase) are n

16 d levels of transducin, PDE6alpha', and cone G-protein coupled receptor kinase-1 (GRK1).

17 ified the pleckstrin homology (PH) domain of G protein-coupled receptor kinase 2 (Gprk2) as an essent

18 in gustatory responses and drive rhythms in G protein-coupled receptor kinase 2 (GPRK2) expression t

19 The levels of G protein-coupled receptor kinase 2 (Gprk2) messenger RN

20 , clock mutant, odorant-receptor mutant, and G protein-coupled receptor kinase 2 (Gprk2) mutant flies

21 The G protein-coupled receptor kinase 2 (Gprk2) phosphorylat

22 G protein-coupled receptor kinase 2 (Gprk2/GRK2) plays a

23 lar to the beta-adrenergic receptor kinases, G protein-coupled receptor kinase 2 (GRK2) and GRK3, is

24 ta(2)AR underwent a rapid phosphorylation by G protein-coupled receptor kinase 2 (GRK2) and subsequen

25 f CD3 epsilon-associated proteins identified G protein-coupled receptor kinase 2 (GRK2) as a candidat

26 vivo neovascularization model, we identified G protein-coupled receptor kinase 2 (GRK2) as a key angi

27 ndocytosis of a subset of GPCRs and identify G protein-coupled receptor kinase 2 (GRK2) as a kinase t

28 Here, we identified G protein-coupled receptor kinase 2 (GRK2) as a new MALT

29 rgic receptor (beta2AR) and other receptors, G protein-coupled receptor kinase 2 (GRK2) can also phos

30 -trisphosphate biosensor eGFP-PH(PLC delta), G protein-coupled receptor kinase 2 (GRK2) can suppress

31 Recently, it was shown that the G protein-coupled receptor kinase 2 (GRK2) contains an R

32 In addition, overexpressing G protein-coupled receptor kinase 2 (GRK2) decreased the

33 Inflammation-induced G protein-coupled receptor kinase 2 (GRK2) downregulatio

34 G protein-coupled receptor kinase 2 (GRK2) is a pharmace

35 G protein-coupled receptor kinase 2 (GRK2) is a serine/t

36 Upregulation of G protein-coupled receptor kinase 2 (GRK2) is a well-est

37 We recently reported that adrenal G protein-coupled receptor kinase 2 (GRK2) is up-regulat

38 alian Smo in an activation-dependent manner: G protein-coupled receptor kinase 2 (GRK2) leads to phos

39 G protein-coupled receptor kinase 2 (GRK2) plays a key r

40 cardial signalling mediated by mitochondrial G protein-coupled receptor kinase 2 (GRK2) pro-death act

41 interference previously to demonstrate that G protein-coupled receptor kinase 2 (GRK2) regulates end

42 take inhibitor paroxetine as an inhibitor of G protein-coupled receptor kinase 2 (GRK2) that improves

43 One target of Gbetagamma is G protein-coupled receptor kinase 2 (GRK2), an enzyme th

44 ed decrease in the hepatic protein levels of G protein-coupled receptor kinase 2 (GRK2), an important

45 Expression of a dominant negative mutant G protein-coupled receptor kinase 2 (GRK2), GRK2-K220R,

46 nventional" 7TM G-protein-coupled receptors, G protein-coupled receptor kinase 2 (GRK2), participates

47 bnormality that leads to the upregulation of G protein-coupled receptor kinase 2 (GRK2), which is pat

48 rase 4D (PDE4D) through transactivation of a G protein-coupled receptor kinase 2 (GRK2)-dependent bet

49 tagamma) subunits and their interaction with G protein-coupled receptor kinase 2 (GRK2).

50 activation-dependent targets, p63RhoGEF and G protein-coupled receptor kinase 2 (GRK2).

51 ered by increased expression and activity of G protein-coupled receptor kinase 2 (GRK2).

52 en functioning together with kinases such as G protein-coupled receptor kinase 2 (GRK2).

53 e-specific expression of a dominant-negative G protein-coupled receptor kinase 2 (GRK2-DN) transgene

54 nsformed human colonocytes, we observed that G protein-coupled receptor kinase 2 and betaARR1/2 termi

55 taARKct, which can inhibit the activation of G protein-coupled receptor kinase 2 and improve betaAR s

56 on of LPA(1) through selective inhibition of G protein-coupled receptor kinase 2 expression and activ

57 CXCR2 and G protein-coupled receptor kinase 2 expressions in neutr

58 The upregulation of G protein-coupled receptor kinase 2 in failing myocardiu

59 downregulation of CXCR2 and upregulation of G protein-coupled receptor kinase 2 in neutrophils was p

60 tor peptide derived from carboxy terminus of G protein-coupled receptor kinase 2 obliterates serum-re

61 vengers-namely, the carboxyl terminus of the G protein-coupled receptor kinase 2 or membrane-targeted

62 RF-RDN also inhibited myocardial G protein-coupled receptor kinase 2 pathological signali

63 RF-RDN reduced oxidative stress, inhibited G protein-coupled receptor kinase 2 signaling, increased

64 sion of this domain mimics the C terminus of G protein-coupled receptor kinase 2, a known G betagamma

65 The inhibition of these protein complexes by G protein-coupled receptor kinase 2, a known Galphaq mod

66 was increased by transient overexpression of G protein-coupled receptor kinase 2, and only Ser352stop

67 terminus of the receptor; kinase activity of G protein-coupled receptor kinase 2, but not of G protei

68 er, when these cells were cotransfected with G protein-coupled receptor kinase 2, in the absence of a

69 igenes encoding the carboxyl terminii of the G protein-coupled receptor kinase 2, or beta-arrestin1,

70 tor-arrestin interaction, the recruitment of G protein-coupled receptor kinase 2, or the receptor-ind

71 ls that the low-efficacy agonist OXY induces G protein-coupled receptor kinase 2-dependent alpha1A-AR

72 lation of cyclin D1, and decreased levels of G protein-coupled receptor kinase 2.

73 crossdesensitization, which was mediated by G protein-coupled receptor kinase 2.

74 s, phosphorylation was mediated primarily by G protein-coupled receptor kinase 2.

75 in the presence of overexpressed arrestin or G protein-coupled receptor kinase 2.

76 Additionally, a mutation in the G protein-coupled receptor kinase 2/PKC regulatory regio

77 G protein-coupled receptor kinases 2 (GRK2) and 5 (GRK5)

78 G protein-coupled receptor kinases 2 and 3 (GRK2/3) coop

79 is associated with selective upregulation of G-protein coupled receptor kinase 2 (GRK2) in both mouse

80 G-protein coupled receptor kinase 2 (GRK2; ADRBK1, BARK1

81 Here, we investigated whether inhibition of G-protein-coupled receptor kinase 2 (GRK2) could counter

82 downregulation was associated with increased G-protein-coupled receptor kinase 2 (GRK2) expression in

83 G-protein-coupled receptor kinase 2 (GRK2) is a G-protei

84 G-protein-coupled receptor kinase 2 (GRK2) is a primary

85 G-protein-coupled receptor kinase 2 (GRK2) is a serine/t

86 Inhibition of G-protein-coupled receptor kinase 2 (GRK2) is an emergin

87 G-protein-coupled receptor kinase 2 (GRK2) is arising as

88 Although G-protein-coupled receptor kinase 2 (GRK2) is the most w

89 We recently identified a novel role for G-protein-coupled receptor kinase 2 (GRK2) that renders

90 sitization and down-regulation (50%) via the G-protein-coupled receptor kinase 2 (GRK2)/PI3K signalin

91 l overexpression of the carboxyl-terminus of G-protein-coupled receptor kinase 2 (GRK2ct), a scavenge

92 G-protein-coupled receptor kinase 2 ablation impedes hea

93 G-protein-coupled receptor kinase 2 ablation represents

94 9 activation in neutrophils, which triggers G-protein-coupled receptor kinase 2 expression and CXCR2

95 tenuated catecholamine secretion, as well as G-protein-coupled receptor kinase 2 expression and membr

96 e oxidase subunit-2-mediated upregulation of G-protein-coupled receptor kinase 2 expression in cardio

97 oxidase subunit-2 prevented upregulation of G-protein-coupled receptor kinase 2 expression in condit

98 by lower parasympathetic tone and increased G-protein-coupled receptor kinase 2 expression in mononu

99 ed cardiac contractility and upregulation of G-protein-coupled receptor kinase 2 expression.

100 nsitions from inhibiting Raf-1 to inhibiting G-protein-coupled receptor kinase 2 upon phosphorylation

101 stress resulting in increased expression of G-protein-coupled receptor kinase 2, a key negative regu

102 rdiomyocytes, attenuated Gbetagamma-mediated G-protein-coupled receptor kinase 2-phosphoinositide 3-k

103 eptor 2 (CXCR2) and had reduced induction of G-protein-coupled receptor kinase 2.

104 ealed an increase in phosphorylation of both G-protein-coupled receptor-kinase 2 and beta-arrestin-1,

105 l downregulation, animals lacking C. elegans G protein-coupled receptor kinase-2 (Ce-grk-2) function

106 ough elastase did not promote recruitment of G protein-coupled receptor kinase-2 (GRK(2)) or beta-arr

107 G protein-coupled receptor kinase-2 (GRK2) can phosphory

108 We investigated the potential role of G protein-coupled receptor kinase-2 (GRK2) in modulating

109 G protein-coupled receptor kinase-2 (GRK2) is a critical

110 Myocardial G protein-coupled receptor kinase-2 (GRK2) is upregulate

111 G protein-coupled receptor kinase-2 (GRK2) serine-phosph

112 ted in human HF and several animal models is G protein-coupled receptor kinase-2 (GRK2), a kinase ori

113 trophils via the inhibition of expression of G protein-coupled receptor kinase-2 (GRK2), a serine-thr

114 Overexpression of dominant negative G protein-coupled receptor kinase-2 (GRK2), however, ret

115 One such kinase, G protein-coupled receptor kinase-2 (GRK2), is known to

116 We hypothesized that G protein-coupled receptor kinase-2 (GRK2)-mediated unco

117 which can be regulated by the Ser/Thr kinase G protein-coupled receptor kinase-2 (GRK2).

118 interfering RNA-mediated down-regulation of G protein-coupled receptor kinase-2 and beta-arrestins a

119 Although inhibition of myocardial G protein-coupled receptor kinase-2 enhances cardiac fun

120 negatively regulates the MAP kinase (MAPK), G protein-coupled receptor kinase-2, and NF-kappaB signa

121 chimera in the presence of membrane-anchored G protein-coupled receptor kinase-2.

122 hosphorylation was inhibited by knockdown of G-protein coupled receptor kinase-2 with siRNA.

123 ,i-2,3; regulator of G-protein signaling-10; G-protein coupled receptor kinase-2; phospholipase C bet

124 tein kinase C (PKC) activity and expression, G-protein-coupled receptor kinase-2 (GRK-2) membranous t

125 helial cells (SECs) via its interaction with G-protein-coupled receptor kinase-2 (GRK2) that also pos

126 We found that Akt physically interacts with G-protein-coupled receptor kinase-2 (GRK2), and that thi

127 receptors can be regulated by the actions of G-protein-coupled receptor kinase-2, which triggers dese

128 2 receptors, with regulatory involvement of G-protein-coupled receptor kinase-2.

129 PS treatment also depleted G protein-coupled receptor kinase 3, as well as attenuat

130 rotein-coupled receptor kinase 2, but not of G protein-coupled receptor kinases 3, 5, or 6; and stoic

131 We discovered that G-protein-coupled receptor kinase 3 (GRK3; or beta-adren

132 restin recruitment is required; mice lacking G-protein-coupled receptor kinase 3 also failed to incre

133 Persistently increased activity of G protein-coupled receptor kinase 4 (GRK4), caused by in

134 bout D1R desensitization, especially through G-protein-coupled receptor kinase 4 (GRK4), comparativel

135 G protein-coupled receptor kinase 5 (GRK5) deficiency ha

136 Membrane G protein-coupled receptor kinase 5 (GRK5) deficiency is

137 d by serine 129 phosphorylation by the human G protein-coupled receptor kinase 5 (GRK5) in yeast.

138 cation to a morpholino induced knock-down of G protein-coupled receptor kinase 5 (GRK5) in zebrafish

139 G protein-coupled receptor kinase 5 (GRK5) is a regulato

140 G protein-coupled receptor kinase 5 (GRK5) is a serine/t

141 G protein-coupled receptor kinase 5 (GRK5) plays a key r

142 We demonstrate that G protein-coupled receptor kinase 5 (GRK5) promotes plat

143 tion of beta-ARs, mRNA and protein levels of G protein-coupled receptor kinase 5 (GRK5) were found is

144 G protein-coupled receptor kinase 5 GRK5 plays a key rol

145 re, we demonstrate that arrestin-2 and GRK5 (G protein-coupled receptor kinase 5), proteins that regu

146 We found that G protein-coupled receptor kinases 5 and 6 (GRK5/6), tra

147 endent of G protein activation, requires the G protein-coupled receptor kinases 5 and 6.

148 We demonstrate that EPCR occupancy recruits G-protein coupled receptor kinase 5, thereby inducing be

149 e-miRs, but not their pri-miRs, in beta1AR-, G-protein-coupled receptor kinase 5/6-, and beta-arresti

150 man beta-amyloid precursor protein gene with G protein-coupled receptor kinase-5 (GRK5) knockout mice

151 Rbeta is phosphorylated on seryl residues by G protein-coupled receptor kinase-5 (GRK5), but mechanis

152 have previously shown that overexpression of G protein-coupled receptor kinase 6 (GRK6) enhanced the

153 pidly phosphorylated by protein kinase C and G protein-coupled receptor kinase 6 (GRK6) upon CXCL12 t

154 rylation of FFA4-L is primarily regulated by G protein-coupled receptor kinase 6, whereas protein kin

155 we find that CCR7 signal termination by the G-protein-coupled receptor kinase 6 (GRK6) is crucial fo

156 ng to ezrin and to a C-terminal peptide from G protein-coupled receptor kinase 6A (GRK6A).

157 that a multiprotein kinase cascade involving G protein-coupled receptor kinase 6A controls the Ser(29

158 Inhibition of endogenous GRK6 (G-protein-coupled receptor kinase) activity, by the intr

159 the beta(2)-adrenoceptor (AR) interacts with G protein-coupled receptor kinases and arrestins in an a

160 cle beta-2-adrenergic receptors, mediated by G protein-coupled receptor kinases and arrestins, is pre

161 G protein-coupled receptor regulation by G protein-coupled receptor kinases and beta-arrestins ca

162 without promoting receptor interaction with G protein-coupled receptor kinases and beta-arrestins sh

163 on to beta-agonists is primarily mediated by G protein-coupled receptor kinases and beta-arrestins th

164 on of the receptor, as shown by knockdown of G protein-coupled receptor kinases and phosphorylation-d

165 s are often negatively regulated by specific G protein-coupled receptor kinases and subsequent bindin

166 the contributions of cAMP-dependent kinase, G protein-coupled receptor kinases, and beta-arrestin to

167 Although G protein-coupled receptor kinases are known to play an

168 G protein-coupled receptor kinases are well characterize

169 rovide insights into the roles played by the G protein-coupled receptor kinase/arrestin and protein k

170 efficacy for adenylyl cyclase activation and G protein-coupled receptor kinase/arrestin-mediated dese

171 ell as overexpression of a dominant negative G-protein-coupled receptor kinase construct that sequest

172 bled in a signaling complex with Gbetagamma, G protein-coupled receptor kinase, cyclic adenosine mono

173 microscopy and indirectly by observations of G protein-coupled receptor kinase-derived polypeptides.

174 is characteristic is the high selectivity of G protein-coupled receptor kinases for the activated rec

175 Raf1 and G protein-coupled receptor kinase (GRK) 2 are direct int

176 Knockdown of G protein-coupled receptor kinase (GRK) 2, GRK3, or GRK6

177 e TGR5 association with beta-arrestin 1/2 or G protein-coupled receptor kinase (GRK) 2/5/6, as determ

178 Previously we have shown that G protein-coupled receptor kinase (GRK) 6 plays a major

179 coupled receptor kinase, GRK4gamma, increase G protein-coupled receptor kinase (GRK) activity and cau

180 blocked by dominant-negative forms of either G protein-coupled receptor kinase (GRK) or arrestin, and

181 Because G protein-coupled receptor kinase (GRK) phosphorylation

182 kinase (PKA) site phosphoserine 262 and the G protein-coupled receptor kinase (GRK) site phosphoseri

183 GRK2 is a G protein-coupled receptor kinase (GRK) that is broadly

184 escribe the 2.6-A crystal structure of human G protein-coupled receptor kinase (GRK)-6, a key regulat

185 We investigated the role of G protein-coupled receptor kinase (GRK)-mediated phospho

186 2)AR/G(i) coupling was also dependent on the G protein-coupled receptor kinase (GRK)-mediated phospho

187 rboxyl-terminal serines 355, 356, and 364 in G protein-coupled receptor kinase (GRK)-mediated phospho

188 tion and a less potent, occupancy-dependent, G protein-coupled receptor kinase (GRK)-mediated phospho

189 tor family are regulated ("desensitized") by G protein-coupled receptor kinase (GRK)-mediated recepto

190 rotein activation (cyclic AMP accumulation), G protein-coupled receptor kinase (GRK)-mediated recepto

191 beta-arrestins bind to G protein-coupled receptor kinase (GRK)-phosphorylated s

192 )/Galpha(q)-protein kinase C (PKC) and V(1A)/G protein-coupled receptor kinase (GRK)/beta-arrestin si

193 in striking differences in activation of the G protein-coupled receptor kinase (GRK)/ss-arrestin syst

194 Myocardial G protein-coupled receptor kinase (GRK)2 is a critical r

195 They recruit elevated levels of cytosolic G protein-coupled receptor kinase (GRK)2 to agonist-stim

196 owed that CXCR1 couples predominantly to the G protein-coupled receptor kinase (GRK)2, whereas CXCR2

197 G protein-coupled receptor kinases (GRK) regulate divers

198 tion typically requires phosphorylation by a G-protein-coupled receptor kinase (GRK) and interaction

199 ation into endosomes is dependent upon prior G-protein-coupled receptor kinase (GRK)-mediated phospho

200 phosphorylation by members of the family of G protein-coupled receptor kinases (GRK1-GRK7).

201 lated kinase Erk potentiated activity of the G protein-coupled receptor kinase GRK2 and inhibited neu

202 In addition, shRNA-mediated knockdown of the G protein-coupled receptor kinases (GRK2 and GRK3) had n

203 Overexpression of a G-protein-coupled receptor kinase (GRK2) was able to sta

204 te that under some conditions, at least, the G protein-coupled receptor kinase GRK4 does not display

205 ension, single nucleotide polymorphisms of a G protein-coupled receptor kinase, GRK4gamma, increase G

206 by two distinct mechanisms in HEK-293 cells: G protein-coupled receptor kinase (GRK6)-mediated recept

207 in epithelial cells, others and particularly G protein-coupled receptor kinase, GRK6, appeared select

208 on of G protein coupled receptors (GPCRs) by G protein coupled receptor kinases (GRKs) and the subseq

209 trimeric guanine nucleotide-binding protein (G protein)-coupled receptor kinases (GRKs) is a universa

210 ent donors expressed different levels of the G protein-coupled receptor kinases (GRKs) 2, 3, 5, and 6

211 ted with the VPAC(1) receptor (VPAC(1)R) and G protein-coupled receptor kinases (GRKs) 2, 3, 5, and 6

212 G protein-coupled receptor kinases (GRKs) and arrestins

213 The G protein-coupled receptor kinases (GRKs) and beta-arres

214 Two candidates are G protein-coupled receptor kinases (GRKs) and Regulators

215 G protein-coupled receptor kinases (GRKs) are attractive

216 G protein-coupled receptor kinases (GRKs) are dynamic re

217 G protein-coupled receptor kinases (GRKs) are important

218 G protein-coupled receptor kinases (GRKs) are important

219 G protein-coupled receptor kinases (GRKs) are key regula

220 G protein-coupled receptor kinases (GRKs) are members of

221 G protein-coupled receptor kinases (GRKs) are negative r

222 hosphorylation by protein kinase A (PKA) and G protein-coupled receptor kinases (GRKs) desensitize be

223 G protein-coupled receptor kinases (GRKs) desensitize be

224 There is ongoing debate about the role of G protein-coupled receptor kinases (GRKs) in agonist-ind

225 study, we investigated the role of different G protein-coupled receptor kinases (GRKs) in CXCR1- and

226 vide in vivo evidence for the involvement of G protein-coupled receptor kinases (GRKs) in opioid depe

227 examined the effects of wild type and mutant G protein-coupled receptor kinases (GRKs) on the phospho

228 G protein-coupled receptor kinases (GRKs) phosphorylate

229 G protein-coupled receptor kinases (GRKs) phosphorylate

230 G protein-coupled receptor kinases (GRKs) phosphorylate

231 G protein-coupled receptor kinases (GRKs) phosphorylate

232 G protein-coupled receptor kinases (GRKs) play a central

233 G protein-coupled receptor kinases (GRKs) play a pivotal

234 G protein-coupled receptor kinases (GRKs) regulate cell

235 G protein-coupled receptor kinases (GRKs) represent a cl

236 n of beta-adrenergic receptors (beta ARs) by G protein-coupled receptor kinases (GRKs) results in the

237 G protein-coupled receptor kinases (GRKs) specifically b

238 G protein-coupled receptor kinases (GRKs) specifically p

239 G protein-coupled receptor kinases (GRKs) specifically p

240 ctivated chemoattractant receptors also dock G protein-coupled receptor kinases (GRKs) that help medi

241 Many GPCRs are phosphorylated by G protein-coupled receptor kinases (GRKs), a process tha

242 horylation of mu-opioid receptors (MOPRs) by G protein-coupled receptor kinases (GRKs), followed by a

243 es phosphorylation of activated receptors by G protein-coupled receptor kinases (GRKs), followed by b

244 G protein-coupled receptor kinases (GRKs), in concert wi

245 This process is initiated by G protein-coupled receptor kinases (GRKs), some of which

246 s) after the receptors are phosphorylated by G protein-coupled receptor kinases (GRKs), thereby regul

247 g phosphorylated by members of the family of G protein-coupled receptor kinases (GRKs).

248 proteins: the heterotrimeric G proteins, the G-protein-coupled receptor kinases (GRKs) and the arrest

249 hemokine receptor desensitization induced by G-protein-coupled receptor kinases (GRKs) in the feedbac

250 The small family of G-protein-coupled receptor kinases (GRKs) regulate cell

251 A kinase screen identified G-protein-coupled receptor kinases (GRKs) targeting S471

252 the receptors plus their phosphorylation by G-protein-coupled receptor kinases (GRKs).

253 ogether, D71A receptor was phosphorylated by G protein-coupled receptor kinases in response to TRH.

254 Using in-solution proteomics, GIT1 (G Protein Coupled Receptor Kinase Interacting ArfGAP 1)

255 ding SNVs found in SCZ subjects in the GIT1 (G protein-coupled receptor kinase interacting ArfGAP 1)

256 The G-protein-coupled receptor kinase interacting protein-1

257 Here, we report that GluN3A binds G protein-coupled receptor kinase-interacting protein (G

258 The ArfGAP paxillin kinase linker (PKL)/G protein-coupled receptor kinase-interacting protein (G

259 Here we show that the G protein-coupled receptor kinase-interacting protein (G

260 teracting exchange factor beta (betaPIX) and G protein-coupled receptor kinase-interacting protein (G

261 The G protein-coupled receptor kinase-interacting protein 1

262 s paxillin, focal adhesion kinase (FAK), and G protein-coupled receptor kinase-interacting protein 1

263 GIT1 (G protein-coupled receptor kinase-interacting protein 1)

264 GIT (G protein-coupled receptor kinase-interacting protein) a

265 Recently, a G protein-coupled receptor kinase-interacting protein, G

266 nstrate that presynaptic deletion of the two G protein-coupled receptor kinase-interacting proteins (

267 ine-nucleotide exchange factor (betaPIX) and G protein-coupled receptor kinase-interacting target 1 (

268 Cell signaling molecules c-src, G-protein-coupled receptor kinase-interacting protein (G

269 gnalling complex with paxillin that included G-protein-coupled receptor kinase-interacting protein (G

270 exchange factor (known as Pix or RtGEF) and G-protein-coupled receptor kinase-interacting protein (G

271 The G-protein-coupled receptor kinase-interacting protein 1

272 a complex with the synaptic adaptor protein G-protein-coupled receptor kinase-interacting protein 1

273 rocytes and neural stem cells, we identified G-protein-coupled receptor kinase-interacting protein 1

274 cond showing that eNOS directly bound to the G-protein-coupled receptor kinase-interacting protein 1

275 We also identified GIT1 (G-protein-coupled receptor kinase-interacting protein 1)

276 G-protein-coupled receptor kinase-interacting protein 2

277 n focal adhesion kinase (FAK), paxillin, and G-protein-coupled receptor kinase-interacting proteins G

278 Here we report that G protein-coupled receptor kinase-interactor 2 (GIT2) wa

279 sociated tyrosine phosphosubstrate-1)/Git-1 (G protein-coupled receptor kinase-interactor-1), thus ma

280 G protein-coupled receptor kinase interactors (GITs) reg

281 tion, TIN-X supports exploration of data for G-protein coupled receptors, kinases, ion channels, and

282 e desensitization through phosphorylation by G protein-coupled receptor kinase is supported in tissue

283 a2AR that couples to Gs but does not undergo G protein-coupled receptor kinase-mediated phosphorylati

284 Agonists desensitize betaAR through G protein-coupled receptor kinase-mediated uncoupling an

285 ng sites and phosphorylation of beta(2)AR by G protein-coupled receptor kinase, not by PKA.

286 signal transduction proteins (particularly, G protein-coupled receptors, kinases or proteins involve

287 ve state, in complex with cognate G protein, G-protein-coupled receptor kinase or arrestin), endocyto

288 PLC-beta1ct), the NH(2)-terminal fragment of G protein-coupled receptor kinase, or the regulator of G

289 Moreover, whereas G protein-coupled receptor kinase overexpression can pro

290 Beta-arrestins bind to activated G protein-coupled receptor kinase-phosphorylated recepto

291 However, the G protein-coupled receptor kinase phosphorylation of bet

292 By using mutants of the beta(1)AR lacking G protein-coupled receptor kinase phosphorylation sites

293 ceptors (D2 DARs) have been shown to undergo G-protein-coupled receptor kinase phosphorylation in an

294 GRK2, a G protein-coupled receptor kinase, plays a critical role

295 protein kinase A site serine 261/262 and the G-protein-coupled receptor kinase site serine 355/356 an

296 uires beta(1)AR phosphorylation at consensus G protein-coupled receptor kinase sites and beta-arresti

297 's cytoplasmic tail on previously documented G protein-coupled receptor kinase sites; (ii) recruitmen

298 rotein-coupled receptor kinase 2 (GRK2) is a G-protein-coupled receptor kinase that is ubiquitously e

299 phorylation of agonist-occupied receptors by G-protein-coupled receptor kinases, they bind beta-arres

300 ns were initially shown, in conjunction with G protein-coupled receptor kinases, to be involved in th

301 , we have identified that two members of the G protein-coupled receptor kinases were involved in regu