ライフサイエンスコーパス: G

1 G protein-coupled receptor (GPCR) kinases (GRKs) play a

2 G protein-coupled receptor (GPR) 55 is a putative cannab

3 G protein-coupled receptor signaling is required for the

4 G protein-coupled receptors (GPCRs) are a large family o

5 G protein-coupled receptors (GPCRs) are membrane-bound p

6 G protein-coupled receptors (GPCRs) comprise the largest

7 G-AgP patients received scaling and root planning (SRP),

8 G-protein-coupled receptor SUCNR1 (succinate receptor 1

9 G-protein-coupled receptors (GPCRs) are major signaling

10 G-protein-coupled receptors (GPCRs) are membrane protein

11 G-protein-coupled receptors (GPCRs) comprise the largest

12 G-protein-coupled receptors like the human Y(1) receptor

13 G-quadruplex (G4) is a noncanonical secondary structure

14 G-Quadruplex (G4) structures are four-stranded noncanoni

15 G. vaginalis was the only recognized species in its genu

16 The c.1379 G > A base change and neighboring bases are consistent w

17 rforated 4 mm from the cannula tip with a 25 G needle (tube was kept straight).

18 ion frequency, RNA-i against seven out of 35 G-protein coupled receptors (GPCRs) within the germline

19 conductances per molecule of up to 10(-4.37) G(0) (Pt) and 10(-3.78) G(0) (graphene) were measured, d

20 78-132.89 W cm(-2) at an acceleration of 1-5 G at a supply voltage of 15 V.

21 conversion efficiency of 4.33% under AM 1.5 G solar simulated light.

22 e of up to 10(-4.37) G(0) (Pt) and 10(-3.78) G(0) (graphene) were measured, despite limited electroni

23 orally dosed with CWD from homozygous (G(96)/G(96)) deer were analyzed.

24 reas short telomeric oligonucleotides form a G-hairpin, their longer counterparts form parallel and/o

25 The beta(1)-adrenoceptor (beta(1)AR) is a G-protein-coupled receptor (GPCR) that couples(1) to the

26 GPR81 is a G-protein-coupled receptor for lactate, which is upregul

27 uble protein calmodulin, ligand binding to a G protein-coupled receptor, and activation of an ion cha

28 reas the other also couples effectively to a G protein.

29 ulates renal water excretion by binding to a G(alpha) s-coupled receptor (V2R) in collecting duct cel

30 lpha(2a)-AR heteroreceptor signaling using a G(i)-coupled designer receptor exclusively activated by

31 PGCs utilize a G protein coupled receptor (GPCR), Tre1, to guide front-

32 r with the cytosolic Ca(2+) rise accelerated G(i/o) -mediated TRPC4 activation.

33 onal experiments indicated that the acquired G mutations improved VSV replication, at least in part d

34 ign 'biased' drugs that selectively activate G protein-coupled receptor (GPCR) signaling pathways ben

35 ially act at mu-opioid receptors to activate G protein signaling over betaarrestin2 recruitment produ

36 conventional ternary complex that activates G proteins and an inverse-coupled binary complex that ma

37 Adhesion G protein-coupled receptors (AGPCRs) are a thirty-three-

38 e and alternatively-spliced ECRs of adhesion G protein-coupled receptors (aGPCRs) have key functions

39 The experimental evidence that Adhesion G Protein-Coupled Receptors (aGPCRs) functionally couple

40 GPR56, a member of the adhesion G protein-coupled receptor family, is abundantly express

41 RNA-Interference (RNA-i) constructs against G-proteins, or a dominant negative G-protein eliminated

42 e to form two nonplanar minor-groove-aligned G.C.G.C tetrads.

43 ng activity compared to the ancestral allele G (ADH1B*1).

44 d TRPC4 activation by coincident G(q/11) and G(i/o) pathways and shed light on how aberrant activatio

45 anaesthetics(10), neurotransmitters(13) and G-protein-coupled receptors(13).

46 6.7%) and CG genotypes (33.1% vs. 38.9%) and G allele of rs755622 (79.6% vs. 76.1%, respectively), wh

47 n the large groove of EBV gH/gL (R(152)A and G(49)C) also have decreased binding with EphA2.

48 in the biosynthesis of paraherquamides A and G.

49 tein N and S and showed that the IgM, A, and G Ab responses against receptor-binding domain are signi

50 nist selectivity, and lack of activation and G protein-coupling knowledge have hindered the developme

51 at TNA sequences with a preference for C and G nucleotides in the immediately flanking 5' and 3' regi

52 nderstanding of ligand-gated ion channel and G protein-coupled receptor complexes and discuss strateg

53 teins, such as ligand-gated ion channels and G protein-coupled receptors, has directly enabled the di

54 ured by ERK phosphorylation, chemotaxis, and G(i/o)-mediated cAMP inhibition.

55 protomers faced each other through the F and G alpha-helices, thus blocking the substrate access chan

56 co-pseudopteroxazole, pseudopterosin A-F and G-J aglycones, and (+)-heritonin.

57 protein(2), but it is unclear how GPR52 and G(s) couple for signal transduction and whether a native

58 The current SNP index method and G-statistic method for BSA-Seq data analysis require rel

59 e of conformational changes in the mu-OR and G(i) system and for exploring the path that leads to its

60 resulting from acetylcholine stimulation and G-protein activation resulting from dopaminergic stimula

61 more than 16 perfectly alternating 3' U and G nucleotides become gene-silencing agents.

62 Expression levels of HLA-F and -G were correlated with the pathological complete respons

63 L1-ankyrin-G association was studied using immunoprecipitation, Wes

64 Hence, anti-G-CSFR treatment prevented the development of IRI in the

65 unterparts form parallel and/or antiparallel G-quadruplexes (G4s).

66 we show that ADGRE2/EMR2 and ADGRE5/CD97 are G protein-coupled in a variety of recombinant systems.

67 ASFV-G-Delta8DR inoculated intramuscularly or intranasally (i

68 texts, from characterizing cancer-associated G-protein mutants to neurotransmitter signaling in prima

69 While RB1-mutant cells fail to arrest at G(1)-S in response to cell-cycle restriction point signa

70 ctance (NIR), green fundus autofluorescence (G-FAF), confocal pseudocolor, and retromode deviated to

71 We have chosen AvaII (G GWCC, where W stands for A or T) as a representative o

72 The class B G protein-coupled receptor (GPCR) calcitonin receptor (C

73 Class B G protein-coupled receptors (GPCRs) are important therap

74 ily by Prevotella (17.9%) and Bacteroidaceae G-1 (14.3%).

75 The modification between G and T required the presence of PT between G and A on t

76 G and T required the presence of PT between G and A on the opposite strand.

77 ole of alpha(2a)-AR heteroreceptors and BNST G(i)-GPCR signaling in stress-induced reinstatement of c

78 Next, we mimicked BNST G(i)-coupled alpha(2a)-AR heteroreceptor signaling using

79 r cells, proved to be able to stabilize both G-quadruplexes and R loops and showed a potent cell kill

80 TSWV G(N) is different from other bunyavirus G(N) proteins, they all share similar domain connectivit

81 The butyrate-G-protein-coupled receptor 43-GLP-1 pathway in the intes

82 nstrate that the genome browsers produced by G-OnRamp are effective tools for engaging undergraduates

83 membrane protrusive activity is promoted by G proteins that deplete phosphatidylinositol 4,5-bisphos

84 Besides being regulated by G-protein-coupled receptors, the activity of heterotrime

85 Signaling by G-CSF, a regulator of neutrophil development, traffickin

86 guided base editors convert A*T to G*C, or C*G to T*A, in cellular DNA for precision genome editing.

87 tosine base editors (CBEs) enable targeted C*G-to-T*A conversions in genomic DNA.

88 form two nonplanar minor-groove-aligned G.C.G.C tetrads.

89 ntrast, the m42C modification disrupts the C:G pair and significantly decreases the duplex stability

90 We hypothesized that the protease cathepsin G (CG) may participate in degrading lubricin in synovial

91 al basis for EapH1's inhibition of cathepsin-G, we crystallized EapH1 bound to this protease, solved

92 otease-binding mode for EapH1 with cathepsin-G that was globally similar to that seen in the previous

93 e overexpressed, purified, and characterized G. lovleyi NrfA.

94 ing Database Collaboration (INSDC) (Cochrane G, et al, Nucleic Acids Res, 44:D48-50, 2016) - National

95 ptor-operated TRPC4 activation by coincident G(q/11) and G(i/o) pathways and shed light on how aberra

96 ctivation of a second potassium conductance, G(K(LV)) .

97 he encoded proteins exhibit highly conserved G-protein activities while showing expression differenti

98 cells lacking leucine-rich repeat-containing G-protein coupled receptors (LGRs) 4, 5 and 6 (Lebensohn

99 , as well as alterations in receptor-coupled G-protein activation.

100 These findings highlight that CoV G-N-7 MTase may be a novel target for rational design of

101 Furthermore, the derived G allele of SNP rs12191876, in the inserted region, is a

102 of G-quadruplexes by automatically detecting G-tetrads and treating them as large square blocks.

103 iants who were predicted to develop disease (G+).

104 MC4R is revealed as a structurally divergent G protein-coupled receptor (GPCR), with more similarity

105 -quadruplex and ligand complex, (ii) PRV DNA G-quadruplex, and (iii) an i-motif of human telomeric se

106 ns varying from 1.2 to 14.7 mg/L for epi-DPA-G and from 0.5 to 42.6 mg/L for astilbin.

107 structure of an agonist-bound activated DRD2-G(i) complex reconstituted into a phospholipid membrane.

108 ptor exclusively activated by designer drug (G(i)-DREADD) approach.

109 conserved proteins, elongation factor G (EF-G) and the ribosome recycling factor (RRF).

110 and knockout mice lacking the genes encoding G protein-coupled receptors GPR43 or GPR109A.

111 signaling from gastrin-expressing endocrine (G) cells.

112 nterface, suggesting a mechanism of engaging G-proteins that may have a distinct dependence on PIP(2)

113 nd one of these types of polyphenol extract (G, O or T), using a homogenizer.

114 s represent mechanistically novel, extremely G protein-biased agonists is in question, as is the unde

115 by two conserved proteins, elongation factor G (EF-G) and the ribosome recycling factor (RRF).

116 (th)G's hypochromism was larger for flanking G/C residues but its fluorescence quantum yield (QY) and

117 nt binding of beta-ionone, an antagonist for G protein activation.

118 s confirmed greater (P = 0.003) efficacy for G:G homozygotes (%AUC difference = 43.7, 95%CL = 15.4, 7

119 Pamoic acid is a potent ligand for G protein Coupled Receptor 35 (GPR35) and exhibits antin

120 ng molecule in plants with a requirement for G-proteins to mediate signal transduction, a situation s

121 However, transition from G(1) to S phase is blocked in the absence of Midkine-a,

122 al structure of the RSV surface glycoprotein G in complex with a broadly neutralizing human monoclona

123 Recent structures of family B GPCR-G(s) protein complexes reveal a disruption in the alpha-

124 truncating (c.658C>T; p.Gln220* and c.1370C>G; p.Ser457*) variants in BEST1.

125 of a novel missense variant in CYLD (c.2155A>G, p.M719V) within the linkage region as the genetic cau

126 conversely, the c.73A>G (p.Thr25Ala), c.248A>G (p.Tyr83Cys), c.395G>T (p.Gly132Val), and c.412C>T (p.

127 gain of function, and conversely, the c.73A>G (p.Thr25Ala), c.248A>G (p.Tyr83Cys), c.395G>T (p.Gly13

128 The allele A (ADH1B*2) of the rs1229984: A>G variant in ADH1B is associated with a higher alcohol m

129 rocess, whereas APOBEC signature targeting C>G is activated in the intermediate phase of disease prog

130 7, rs72613567TA>T in HSD17B13 and rs2642438A>G in MTARC1.

131 les associated with NASH-fibrosis: rs738409C>G in PNPLA3, rs58542926C>T in TM6SF2, rs641738C>T near M

132 The wG-T->G-T* tautomerization is predicted to be endoergic in aqu

133 In contrast, guaiacyl (G) lignin, the other major type of lignin monomer, is de

134 Heterotrimeric G-proteins (Galphabetagamma) are the main transducers of

135 Heterotrimeric G-proteins are key modulators of multiple signaling and

136 ivating beta-arrestin but not heterotrimeric G(q) protein signaling.

137 ed receptors, the activity of heterotrimeric G proteins is modulated by many cytoplasmic proteins.

138 process is the activation of heterotrimeric G-protein Gs by beta(1)-ARs, leading to increased heart

139 (GPCR) that couples(1) to the heterotrimeric G protein G(s).

140 occurs primarily through the heterotrimeric G(s) protein(2), but it is unclear how GPR52 and G(s) co

141 GPCRs) functionally couple to heterotrimeric G proteins has been emerging in incremental steps, but a

142 Samples from heterozygous (G(96)/S(96)) white-tailed deer orally dosed with CWD fro

143 deer orally dosed with CWD from homozygous (G(96)/G(96)) deer were analyzed.

144 lection of papers offers perspectives on how G-E interplay operates contingently within and against a

145 mean recovery of (93 +/- 3%) for urinary HP-G at three concentration levels with adequate detection

146 st-based reporter strains for studying human G protein-coupled receptors (GPCRs), the largest class o

147 ing antibodies, anti RSV-F immunoglobin (Ig) G, and ChAd155 neutralizing antibodies.

148 test that detected SARS-CoV-2 immunoglobulin G (IgG) and immunoglobulin M (IgM) antibodies was undert

149 whereas immunoglobulin M and immunoglobulin G antibodies were positive in 15.7% cases and immunoglob

150 e positive in 15.7% cases and immunoglobulin G in 43.6% cases, respectively, when checked.

151 Nab titers and immunoglobulin G levels were correlated in donor plasma units (rho = 0.

152 assessed for antipneumococcal immunoglobulin G (IgG) antibody titers against the 7 serotypes shared b

153 by autologous contemporaneous immunoglobulin G (IgG).

154 ostvaccination was tested for immunoglobulin G antibodies to P. falciparum circumsporozoite protein (

155 ntibodies and anti-RSV fusion immunoglobulin G increased >=4-fold in 95% and 100% of vaccines, respec

156 However, immunoglobulin G (IgG) can also stimulate antiviral responses through i

157 determining regions of human Immunoglobulin G antibodies with target affinities that are superior to

158 cans from ovalbumin and human immunoglobulin G.

159 ce antibody assay to identify immunoglobulin G (IgG) antibodies reactive with Rickettsia rickettsii.

160 munoassay developed for mouse immunoglobulin G, detection limits of 1.5 ng/mL and >10 ng/mL were achi

161 nfection by identification of immunoglobulin G (IgG) antibodies against T. gondii embryogenesis-relat

162 g different concentrations of Immunoglobulin G (IgG) in both phosphate buffered saline (PBS) and spik

163 >300-fold higher than that of immunoglobulin G/liposomes.

164 erotype-specific pneumococcal immunoglobulin G antibody concentrations at baseline and 4-8 weeks post

165 (P < .001), but not anti-PRN immunoglobulin G, were observed among 69 wP-vaccinated infants born to

166 model of the antibody protein immunoglobulin G using fluctuating finite element analysis and use it t

167 Mumps virus-specific immunoglobulin G (IgG) antibody responses and mumps virus-neutralizing

168 differences in EBOV-specific immunoglobulin G, antinuclear antibody, or anti-cyclic citrullinated pe

169 hey were predominantly of the immunoglobulin G (IgG) class and targeted the S2 subunit.

170 iagnostic efficacy similar to immunoglobulin G (IgG) index and neurofilament light chain (area under

171 sed anti-spike protein trimer immunoglobulin G inhibited angiotensin-converting enzyme 2-spike protei

172 the longitudinal dynamics of immunoglobulin-G (IgG), immunoglobulin-M (IgM), and in vitro neutralizi

173 complement tests that detect immunoglobulins G and M.

174 Premature activation of Akt in G(1) phase causes an early switch and inhibits DNA repli

175 Thus, Rb dilution through cell growth in G(1) provides one of the long-sought molecular mechanism

176 identified novel eNOS interactors, including G protein-coupled receptor (GPCR) kinase interactor 1 (G

177 thors discovered a pathway linking increased G-3-P to increased FGF23 via increases in lysophosphatid

178 The increased G-CSF was accompanied by an increased activation of the

179 exhibits a low level of agonist-independent G protein activation.

180 l approach allows separation of K(+)-induced G-quadruplex formation and subsequent refolding and prov

181 The inhibitory G protein alpha-subunit (Galpha(z)) is an important modu

182 e fine-mapped the SCR74 receptor to a 43-kbp G-LecRK locus.

183 y synthesized cycloparaphenylene lemniscates G have been explored at omegaB97X-D/6-311G(d).

184 uropeptides that activate the rhodopsin-like G protein-coupled receptors OX1R and OX2R.

185 us correlating with the accumulation of long G-overhangs.

186 ted in transcriptional readthrough and lower G and fusion (F) protein levels than for the wild type.

187 ve locomotion in the absence of D2R-mediated G protein signaling.

188 omeric G-quadruplex multimers over monomeric G-quadruplexes with high selectivity, and induced the fo

189 is introduced in differentiating multimeric G-quadruplexes over monomeric species, which would be ab

190 Multiple G protein-coupled receptors (GPCRs) are targets in the t

191 fforts to convert the diosphenol (-)-myrocin G (4) to the corresponding 5-hydroxy-gamma-lactone isome

192 s against G-proteins, or a dominant negative G-protein eliminated the increase in GSC division freque

193 019; APP-SL70: R = 0.410, P = 0.037; App (NL-G-F) : R = 0.385, P = 0.002).

194 np-G(2) BDS reverts to zCO(2) @p-G(2) BDS or yXe@p-G(2) BDS

195 13)-NH(2) is a useful strategy for obtaining G protein biased agonists for the NOP receptor.

196 2, N, P, M, and SH ORFs), Max B (with CPO of G and F), Max L (with CPO of L), and Max FLC (with CPO o

197 R can dramatically simplify the depiction of G-quadruplexes by automatically detecting G-tetrads and

198 ades, but recently an emended description of G. vaginalis and descriptions of three new species - Gar

199 eatic islets, we investigated the effects of G protein subunit beta 5 (Gnb5) knockout on insulin secr

200 e diversity and near universal expression of G protein-coupled receptors (GPCR) reflects their involv

201 gh selectivity, and induced the formation of G-quadruplex DNA along with the related DNA damage respo

202 fluorescence and inhibits ROS generation of G.

203 no acid changes in the hypervariable part of G protein may have altered functions and/or changed its

204 within this region highlighted regulator of G-protein signaling 4 (Rgs4) within laser-capture micro-

205 This suggests, therefore, that the retina of G. australis possesses five spectrally and morphological

206 513 providing electrostatic stabilization of G-T*.

207 ides key insight into rate-limiting steps of G-quadruplex conformational dynamics.

208 ous system development, including a suite of G-protein-coupled receptors that control physiology and

209 licit host production of mediators acting on G-protein-coupled receptors to regulate airway tone.

210 tive wild isolates, and deletion of the only G-protein beta-subunit-encoding gene of A. oligospora ne

211 acids: Valine (coded by GUX [X = U, C, A or G]), alanine (coded by GCX), aspartic acid (coded by GAY

212 r C]), glutamic acid (coded by GAZ [Z = A or G]), glycine (coded by GGX), Ser (coded by AGY), and Arg

213 balance via several nuclear receptors and/or G-protein-coupled receptors(3,4).

214 GPR52 is a class-A orphan G-protein-coupled receptor that is highly expressed in t

215 GPR88 is an orphan G protein-coupled receptor (GPCR) considered as a promis

216 In the absence of protein contacts, oxoA:G forms a wobble conformation, the formation of which is

217 np-G(2) BDS reverts to zCO(2) @p-G(2) BDS or yXe@p-G(2) BDS (y,z=variable) when pressure

218 ) BDS reverts to zCO(2) @p-G(2) BDS or yXe@p-G(2) BDS (y,z=variable) when pressure of CO(2) or Xe, re

219 romoter folds into a stacked, three-parallel G-quadruplex structure.

220 that conferred a 2-fold increased penicillin G and ampicillin MIC among the isolates tested.

221 main effector genes for producing penicillin G (pcbAB, pcbC and penDE) show amino acid divergence bet

222 We also find that regulation by PfAP2-G requires interaction with a second transcription facto

223 yte genes, and identify differences in PfAP2-G occupancy between gametocytes derived via next-cycle a

224 Here we identify the direct targets of PfAP2-G and demonstrate that it dynamically binds hundreds of

225 results clarify the functional role of PfAP2-G during sexual commitment and early gametocytogenesis.

226 We find that PfAP2-G is a transcriptional activator of early gametocyte gen

227 the pyrG promoter, which contains eight poly-G RNA bases synthesized using three C bases in the DNA a

228 me label-free techniques are used to profile G protein-coupled receptor (GPCR) signaling pathways in

229 t couples(1) to the heterotrimeric G protein G(s).

230 etic and genomic data, we show that putative G-quadruplex forming sequences (pG4) in 5' and 3' UTRs a

231 derwent evaluation for uveitis including QFT-G testing.

232 ntains the main binding interface to the RAS G domain, its cysteine-rich domain (CRD) is responsible

233 n this system involves two distinct receptor-G protein complexes, a conventional ternary complex that

234 ection of two putative fatty acid receptors, G protein-coupled receptor 120 (GPR120) and cluster of d

235 he F conformational cascade (still requiring G).

236 ally unwinding RNA:DNA hybrids and resolving G-quadruplex structures.

237 Overexpression of Rig-G led to significantly reduced cell growth and suppresse

238 ructures of (i) Pseudorabies virus (PRV) RNA G-quadruplex and ligand complex, (ii) PRV DNA G-quadrupl

239 Rho of Plants (ROP) G-proteins are key components of cell polarization proce

240 ion not observed in previously described RSV G-antibody structures.

241 While the serum RSV G antibody repertoires in the 2 groups were similar, the

242 Surprisingly, RSV G complexed with 3G12 adopts a distinct conformation not

243 Antibodies targeting the RSV G central conserved domain are protective in both prophy

244 ignificantly higher antibody affinity to RSV G was observed in nasal washes from early-recovered indi

245 t solid polyphenol extracts from grape seed (G), grape seed and olive (O) or grape total (T), called

246 wed the identification of a highly selective G-quadruplex ligand that, when studied in human cancer c

247 A single G-quadruplex forming sequence from the human telomere ca

248 ction is greatly amplified by Rab5A, a small G protein of the Ras GTPase superfamily.

249 ence of EXO1, forks accumulate at stabilized G-quadruplexes and ultimately collapse.

250 ver junction is held together by two stacked G:C pairs at the central core that rotate with respect t

251 tributes to PF-PC LTP.SIGNIFICANCE STATEMENT G-protein-coupled receptors modulate the release machine

252 1-bound CRF1R and CRF2R with the stimulatory G protein.

253 of increased ATP-binding cassette subfamily G member 5/8 activity given that NTCP inhibition still p

254 Our results suggest G-CSFR blockade as a promising therapeutic approach to a

255 ymidine analogs along with the natural A, T, G and C bases during DNA synthesis, which allows for lab

256 gand, BMPQ-1, which bound to human telomeric G-quadruplex multimers over monomeric G-quadruplexes wit

257 ution of, and replication through, telomeric G-quadruplexes.

258 ion experiments revealed that the N-terminal G domain of GBP2 mediates these anti-MNV effects.

259 In matched duplexes, (th)G's hypochromism was larger for flanking G/C residues bu

260 Moreover, (th)G's dominant fluorescence lifetime in DNA is unusually l

261 Unexpectedly, we discovered that G. stearothermophilus T-1 can also utilize lactose and g

262 The G allele of the lead risk single nucleotide polymorphism

263 The G(i/o) -mediated TRPC4 activation is dually dependent on

264 The G(s)alpha mutation results in dysregulation of the cAMP

265 ceptors such as Farnesoid X Receptor and the G protein-coupled BA receptor 1 (TGR5).

266 e near intracellular loop (ICL) 2/TM3 at the G-protein-coupling interface, suggesting a mechanism of

267 ping revealed a druggable site formed by the G protein fusion loops that has not previously emerged a

268 Consistent with a role for the G-proteins in regulating GSC division frequency, RNA-i a

269 s cell cycle-dependent; it was higher in the G(2)-M phase and diminished upon G(1) entry.

270 th the vast majority of treated cells in the G(2)/M phase (89%); 2) induces cell death in PC3 cells e

271 NLRP3 and IL-1beta were upregulated in the G, CP, and AgP groups compared with group H (P < 0.05).

272 S, in which the membrane-distal state of the G-domain can effectively recruit RAF kinase from the cyt

273 inhibit nucleotide exchange depending on the G-protein subtype.

274 etic mobility shift assay suggested that the G allele interacted with CCAAT/enhancer-binding protein

275 te that GBA motifs have versatility in their G-protein-modulating effect, i.e. they can bind to Galph

276 attributing biological significance to their G protein signalling function still presents a major cha

277 mers by modifying their sequences upon their G-quadruplex and secondary structures.

278 GABBR2 inhibits neuronal activity through G protein-coupled second-messenger systems and RUFY3 is

279 Efflux of K(+) through G(BK) can rapidly elevate [K(+) ](c) , which speeds the

280 and, given that this peptide signals through G-protein coupled receptors, this signalling pathway pro

281 ing domain that exhibits specific binding to G-quadruplex (G4) DNA structures.

282 2 in each assay studied and does not lead to G protein activation.

283 and IL-8 (adjusted p = 0.0170) responses to G. vaginalis.

284 RISPR-Cas-guided base editors convert A*T to G*C, or C*G to T*A, in cellular DNA for precision genome

285 show that CGBE1 can efficiently induce C-to-G edits, particularly in AT-rich sequence contexts in hu

286 se editing in human cells and enabled A*T-to-G*C base editing of a sickle cell anemia mutation using

287 Tsivgoulis G, Katsanos AH, Malhotra K, et al.

288 Although the structure of the TSWV G(N) is different from other bunyavirus G(N) proteins, t

289 The orexin system, which consists of the two G protein-coupled receptors OX(1) and OX(2), activated b

290 UDP-G decreased the reductive capacity of nondiabetic human

291 gher in the G(2)-M phase and diminished upon G(1) entry.

292 Here, we use G-deleted rabies virus-mediated monosynaptic tracing to

293 We used G-quadruplex-stabilizing ligand to define the inhibition

294 r neurons revealed that GPR139 signaling via G(q/11) is necessary and sufficient for counteracting MO

295 ce interaction, with higher FPS in the CC vs G allele groups among those with higher violence exposur

296 ted a set of chimeras composed of gB and VSV-G or gp64, respectively.

297 The mechanisms by which G-quadruplexes transition from one folded conformation t

298 ptors in their inactive state associate with G(s), as these complexes are stabilized by inverse agoni

299 ity-modifying proteins (RAMPs) interact with G-protein-coupled receptors (GPCRs) to modify their func

300 The formation of the host-guest complex WP5 G quenches the fluorescence and inhibits ROS generation