ライフサイエンスコーパス: GABA(A) receptor

1 eroid binding sites in the human alpha1beta3 GABAA receptor.

2 ines are secreted peptides that modulate the GABAA receptor.

3 g domains through which propofol acts on the GABAA receptor.

4 d by clonazepam, a positive modulator of the GABAA receptor.

5 y via a pentameric chloride ion channel, the GABAA receptor.

6 ibuting to neurosteroid interaction with the GABAA receptors.

7 such as hetero-oligomeric alpha1beta2gamma2 GABAA receptors.

8 oactive steroids potentiate a wider-range of GABAA receptors.

9 els, in particular, by enhancing activity of GABAA receptors.

10 ts, abolished by pharmacological blockade of GABAA receptors.

11 r type 1, oxytocin, ionotropic glutamate and GABAA receptors.

12 modulator of both synaptic and extrasynaptic GABAA receptors.

13 synaptic trapping of glycine (GlyR) but not GABAA receptors.

14 ical structure acting as a PAM at particular GABAA receptors.

15 uld be compensated for by an upregulation of GABAA receptors.

16 dation process remains poorly understood for GABAA receptors.

17 ric activation of synaptic and extrasynaptic GABAA receptors.

18 ines the hyperpolarizing action of GABA) and GABAA receptors.

19 etic with putative actions on the inhibitory GABAA receptors.

20 the effect was shown to be mediated via the GABA(A) receptor.

21 aria and a potent orthosteric agonist of the GABA(A) receptor.

22 tamate transporters EAAT1 and EAAT2, and the GABA(A) receptor.

23 ibits the human alpha (2) beta (3) gamma (2) GABA(A) receptor.

24 to the modes of action of these drugs on the GABA(A) receptor.

25 ty for brain gamma-aminobutyric acid type A (GABAA) receptors.

26 reversal potential of inhibitory glycine and GABA(A) receptors.

27 ious stimulation of the colon, primarily via GABA(A) receptors.

28 lular stores are necessary for modulation of GABA(A) receptors.

29 ch has focused on studying alpha5-containing GABA(A) receptors.

30 atory AMPA receptors (AMPARs) and inhibitory GABA(A) receptors.

31 property associated with outward rectifying GABA(A) receptors.

32 o the activity-induced dispersal of synaptic GABA(A) receptors.

33 protein (GABARAP) to stabilize cell surface GABA(A) receptors.

34 pha5beta3gamma2 over other alphaxbeta3gamma2 GABA(A) receptors.

35 ogical and pharmacological properties of the GABA(A) receptors.

36 tonic GABA current mediated by extrasynaptic GABA(A) receptors.

37 onses of the gamma-aminobutyric acid type A (GABA(A)) receptor.

38 mprising the gamma-aminobutyric acid type A (GABA(A)) receptor.

39 ent in the brain are the alpha1beta2/3gamma2 GABA(A) receptors(5).

40 lcohol as a positive allosteric modulator of GABA(A) receptors, a decrease in dopamine function, and

41 arizing vs. hyperpolarizing) of postsynaptic GABAA receptor actions.

42 increases membrane depolarization induced by GABA(A) receptor activation in these neurons.

43 Excitation of GABA neurons was mediated by GABAA receptor activation and involved stress-induced fu

44 urround light responses depend on endogenous GABAA receptor activation.

45 pathomimetics, pancreatic lipase inhibitors, GABAA receptor activators, a serotonin 2C receptor agoni

46 was to provide a model-based description of GABA(A) receptor activity under steady-state conditions

47 ats by locally concentrating and releasing a GABA(A) receptor agonist from ultrasound-controlled carr

48 ute treatment with a peripherally restricted GABA(A) receptor agonist that acts directly on mechanose

49 n rats by microinjection of small amounts of GABAA-receptor agonists into an upper brainstem region n

50 ecting brain-state switching when exposed to GABAA-receptor agonists.

51 tional relationship between delta and gamma2 GABA(A) receptors akin to that of slow NMDA and fast AMP

52 ediol, are neuroactive steroids and positive GABAA receptor allosteric modulators.

53 everity of seizures which is correlated with GABA(A) receptor alpha(2) subunit expression.

54 he hypotheses, indicating that loop C of the GABA(A) receptor alpha-subunit is the dominant molecular

55 These findings implicate movement of the GABAA receptor alpha1 subunit's beta1 strand during agon

56 low concentrations was absent in slices from GABAA receptor alpha1(H101R)mutant mice.

57 -1 (~20%) levels, as well as TLR4 binding to GABA(A) receptor alpha2 subunits (~60%) and MyD88 (~40%)

58 associated with increased expression of the GABA(A) receptor alpha2 subunits by 93%, and these chang

59 However, no expression of GABAA receptor alpha2 subunit was detected.

60 ry approaches, we compared effects of mutant GABAA receptor alpha5 and alpha1 subunits on the propert

61 The alpha5 subunit-containing GABA(A) receptor (alpha5-GABA(A)R) is abundantly express

62 g to (i) the orthosteric binding site of the GABA(A) receptor and (ii) the high-affinity GHB binding

63 acterized at native and selected recombinant GABA(A) receptors and GABA transporters.

64 ) affinity selectivity for alpha5-containing GABA(A) receptors and show atom-level structure predicti

65 luences ligand-gated channels, including the GABAA receptor and others.

66 the postsynaptic clustering of gephyrin and GABAA receptors and the strength of inhibitory, but not

67 antibodies against NMDAR, LGI1, CASPR2, the GABAA receptor, and the AMPA receptor using live cell-ba

68 -treated rats and this effect was blocked by GABAA receptor antagonism.

69 the NMDA receptor antagonist MK-801 and the GABA(A) receptor antagonist bicuculline methiodide while

70 tructurally dense (1.64 mcbits/ angstrom(3)) GABA(A) receptor antagonist bilobalide, intermediates en

71 The mutation imparts resistance to the GABA(A) receptor antagonist picrotoxin, allowing verific

72 intra-BLA administration of a low dose of a GABA(A) receptor antagonist, but not an NMDA/AMPA/kainat

73 Gabazine, a gamma-aminobutyric acid type A (GABA(A)) receptor antagonist, has previously been report

74 inephrine or serotonin, was prevented by the GABAA receptor antagonist picrotoxin.

75 Administration of either bicuculline, a GABAA receptor antagonist, or CGP 35348, a GABAB recepto

76 , the VMR was only consistently increased by GABA(A) receptor antagonists.

77 Synaptic GABA(A) receptors are alternately exposed to short pulse

78 Structures in which GABA(A) receptors are bound by benzodiazepine-site ligan

79 GABA(A) receptors are composed of five subunits arranged

80 der both physiologic and clinical conditions GABA(A) receptors are exposed to multiple agonists, incl

81 Type-A gamma-aminobutyric (GABA(A)) receptors are ligand-gated chloride channels wi

82 Type A gamma-aminobutyric acid (GABA(A)) receptors are pentameric ligand-gated ion chann

83 GABAA receptors are brain inhibitory chloride ion channe

84 alpha4betaxdelta GABAA receptors are extrasynaptic receptors important fo

85 y and arrangement of synaptic alphabetagamma GABAA receptors are generally accepted as 2alpha:2beta:1

86 While gamma amino-butyric acid Type A (GABAA) receptors are the primary molecular targets of ne

87 ents mediated by high-affinity extrasynaptic GABAA receptors, are increasingly recognized as importan

88 itive modulators of chloride (Cl-) permeable GABAA receptors, are indicated as first-line treatment,

89 Previous studies have identified GABA(A) receptors as the primary targets of most anesthe

90 nd its encoded beta3 subunit is critical for GABAA receptor assembly and trafficking as well as stem

91 eurons, where it interacts directly with the GABA(A) receptor-associated protein (GABARAP) to stabili

92 teracting at the NCA site in the pore of the GABA(A) receptor at a location that is overlapping but n

93 ficient per se, for efficient recruitment of GABA(A) receptors at GABAergic synapses in C. elegans Th

94 scaffold protein mediating the anchoring of GABAA receptors at inhibitory synapses.

95 nted gamma2 subunits from incorporating into GABAA receptors at synapses, although by different cellu

96 devoid of any intrinsic activity toward the GABA(A) receptor before irradiation.

97 for three de novo missense mutations in the GABAA receptor beta3 subunit gene (GABRB3) identified in

98 , 5-7, displayed moderate GAT activities and GABA(A) receptor binding affinities in the mid-nanomolar

99 s with the high-affinity GHB and orthosteric GABA(A) receptor binding sites differently and that dist

100 zed the effects of these GABRG2 mutations on GABAA receptor biogenesis and channel function.

101 ecular mechanisms that might link defects in GABAA receptor biophysics and biogenesis to patients wit

102 In long-term bioluminescence recordings, GABAA receptor blockade desynchronized the Fbxl3(+/+) bu

103 were sustained by GABAergic signaling, as a GABA(A) receptor blocker stopped them in 2 of 3 slices.

104 tagonist) or by (2) bicuculline (a preferent GABA(A) receptor blocker), suggesting a GABAergic activa

105 esent cryo-electron microscopy structures of GABA(A) receptors bound to intravenous anaesthetics, ben

106 receptor, oxytocin, ionotropic glutamate or GABAA receptors but instead involves a close relationshi

107 ation of the concatemeric alpha1beta2gamma2L GABA(A) receptor by combinations of agonists.

108 The study describes modulation of the rho1 GABA(A) receptor by neurosteroids.

109 dy, we analyzed modulation of the human rho1 GABA(A) receptor by several neurosteroids, individually

110 been used to describe the activation of the GABA(A) receptor by the transmitter, GABA, and drugs tha

111 on of the GABA signaling and blockage of the GABAA receptor by the specific inhibitors both significa

112 the EC50 for activation of the GABA type A (GABAA) receptor by the transmitter GABA and basal activi

113 nding isotherms from recombinant alpha1beta3 GABA(A) receptors can be qualitatively predicted using e

114 In nonrhythmic conditions, antagonizing GABA(A) receptors can initiate this synchronization whil

115 GABAA receptors can be directly activated and potentiate

116 be related to the extent of the reduction of GABAA receptor channel function and the differential dom

117 apses primarily on dendritic spines, whereas GABAA receptors cluster at inhibitory synapses mainly on

118 se gamma2 subunits are critical for synaptic GABAA receptor clustering, this provides an important cl

119 onal gray matter increases were explained by GABAA receptor concentration in addition to T1 relaxatio

120 rogate marker of water content, but not with GABAA receptor concentration, a surrogate of neuronal in

121 ontent, and not to any substantial degree by GABAA receptor concentration, an indirect marker of neur

122 ay matter increases were partly explained by GABAA receptor concentration, indicating some form of ne

123 e activity is associated with a reduction in GABAA receptor conductance and Cl- extrusion capability.

124 Activation of GABA(A) receptors consisting of alpha4, beta2 (or beta3)

125 with wild-type alpha1beta2gamma2L receptors, GABAA receptors containing a mutant gamma2 subunit had r

126 GABAA receptors containing mutant alpha5 and alpha1 subu

127 GABAA receptors containing subunit alpha1, showing the s

128 a, DCUK-OEt acted primarily on extrasynaptic GABAA receptors containing the alpha1 subunit and genera

129 g mechanism involves membrane-shunting tonic GABA(A) receptor current; it does not have to rely on I(

130 e tonically active and enhance extrasynaptic GABA(A) receptor currents in cerebellar granule cells.

131 uding extrasynaptic delta subunit-containing GABA(A) receptors (delta-GABA(A)Rs) that mediate tonic i

132 ions of interest, we found no differences in GABA(A) receptor densities between ASD and TD groups.

133 We measured both total GABA(A) receptor densities by using [(18)F]flumazenil po

134 eous acquisitions of GABA concentrations and GABA(A) receptor densities can identify objective molecu

135 Low-threshold cutaneous afferents evoke a GABA(A)-receptor-dependent form of PSI that inhibits sim

136 cell volume homeostasis and Cl(-)-permeable GABAA receptor-dependent membrane excitability.

137 ervation is particularly interesting because GABAA receptor disturbances, leading to altered behavior

138 quantify and predict the loss of activatable GABA(A) receptors due to desensitization in the presence

139 rrecting the disrupted driving force through GABA(A) receptors during the CP in cortical neurons rest

140 e phenotypic spectrum is comparable to other GABA(A) receptor-encoding genes.

141 tested using concatemeric alpha1beta2gamma2 GABA(A) receptors expressed in Xenopus oocytes.

142 By using recombinant GABAA receptors expressed in HEK293 cells, and native GA

143 asal activity employing concatemeric ternary GABAA receptors expressed in Xenopus oocytes.

144 results suggest a complex interplay between GABA(A) receptor expression by spinally projecting C1 an

145 and D1 receptor activation result in minimal GABAA receptor expression and activity and greatly dimin

146 steric modulator of gamma-aminobutyric acid (GABAA) receptors, for the treatment of post-partum depre

147 e brain during CO2 compensation could change GABAA receptor function and account for the behavioural

148 ssing, impaired synaptic clustering, reduced GABAA receptor function and decreased GABA binding poten

149 play a role in ethanol-induced sedation and GABAA receptor function, but does not regulate excessive

150 l amygdala neurons, deletion of Tlr4 altered GABAA receptor function, but not GABA release.

151 anisms by which EOEE-linked mutations affect GABAA receptor function.

152 crease of fEPSP is induced by a reduction in GABAA receptor function.

153 vity of interneurons and the distribution of GABA(A) receptor (GABA(A) R) subtypes, distinguished by

154 steroid-binding sites in the alpha(1)beta(3) GABA(A) receptor (GABA(A)R) contributes to neurosteroid

155 ering of seizures at room temperature by the GABA(A) receptor (GABA(A)R) positive allosteric modulato

156 ndently, of retinal environment age on their GABA(A) receptor (GABA(A)R) responses, elicited by musci

157 4 and 11 during pharmacological blockade of GABA(A) receptors (GABA(A) Rs) and/or glycine receptors

158 tameric ligand-gated ion channels, including GABA(A) receptors (GABA(A)R) and nicotinic acetylcholine

159 GABA(A) receptors (GABA(A)Rs) are pentameric ligand-gate

160 GABA(A) receptors (GABA(A)Rs) are profoundly important f

161 GABA(A) receptors (GABA(A)Rs) are targets for important

162 GABAergic signaling through GABA(A) receptors (GABA(A)Rs) expressed in the oligodend

163 Behaviorally, loss of either GABA(A) receptors (GABA(A)Rs) or NMDA receptors (NMDARs)

164 Oligodendrocytes (OLs) express functional GABA(A) receptors (GABA(A)Rs) that are activated by GABA

165 ent positive allosteric modulators (PAMs) of GABA(A) receptors (GABA(A)Rs) with in vivo anesthetic, a

166 n in the brain is mediated by GABA acting on GABA(A) receptors (GABA(A)Rs), which provides inhibitory

167 n, which is a scaffold protein that recruits GABAA receptors (GABAA Rs) at the postsynapse.

168 ctional modulators of heterologous expressed GABAA receptor (GABAAR) isoforms (synaptic alpha1beta3ga

169 GABAA receptor (GABAAR) pentamers are assembled from a p

170 he interaction between oxytocin receptor and GABAA receptor (GABAAR), remains to be elucidated.

171 we report a mechanism of KCC2 regulation by GABAA receptor (GABAAR)-mediated transmission in mature

172 experience depolarization upon activation of GABAA receptors (GABAAR) because their intracellular chl

173 ition in the brain is mediated by ionotropic GABAA receptors (GABAARs) and metabotropic GABAB recepto

174 n the brain is mediated mostly by ionotropic GABAA receptors (GABAARs), but their essential component

175 expression of extrasynaptic alpha4betadelta GABAA receptors (GABARs).

176 mpaired postsynaptic clustering of wild-type GABAA receptor gamma2 subunits and prevented gamma2 subu

177 s, the closed and desensitized states of the GABA(A) receptor gating cycle, and the basis for alloste

178 The drug also caused changes in GABA(A) receptor gating properties in the vHipp with res

179 A (gamma-aminobutyric acid) to extrasynaptic GABA(A) receptors generates tonic inhibition that acts a

180 fect is mediated by the loss of postsynaptic GABA(A) receptors, gephyrin, and neuroligin 2 and does n

181 onal importance of residues in loop G of the GABAA receptor has not been investigated.

182 No caged allosteric modulators of the GABA(A) receptor have been reported so far; to introduce

183 e accurate structural models for heteromeric GABA(A) receptors have been hampered by the use of engin

184 tion for a human membrane protein, the beta3 GABA(A) receptor homopentamer(3).

185 the blockade of both glutamatergic NMDA and GABA(A) receptors improved neuronal selectivity of delay

186 ich the full-length human alpha1beta3gamma2L GABA(A) receptor in lipid nanodiscs is bound to the chan

187 he central nervous system, alpha5-containing GABA(A) receptors in airway smooth muscles are considere

188 Structures of GABA(A) receptors in complex with the anaesthetics pheno

189 tions, a major risk factor for CVD, increase GABA(A) receptors in RVLM, including its rostral extensi

190 as been used to evaluate the distribution of GABA(A) receptors in the brain, and studies of modulatio

191 The majority of GABA(A) receptors in the mammalian brain consist of two

192 force for the chloride-permeable ionotropic GABAA receptor in mature neurons.

193 duces its anesthetic effect, largely via the GABAA receptor in the CNS, and also reduces the N-formyl

194 nant alpha5beta3gamma2 and alpha1beta3gamma2 GABAA receptors in both neuronal and non-neuronal cells

195 s the function of synaptic and extrasynaptic GABAA receptors in physiologic and pathologic conditions

196 ale for targeting synaptic and extrasynaptic GABAA receptors in the development of therapies for pati

197 This differs from GABAA receptors in the dorsal horn, where different rece

198 data on the distribution and composition of GABAA receptors in the human amygdala are lacking.

199 irregularity; (iii) conversely, blockade of GABAA receptors in the KF of healthy rats mimicked the R

200 BAA receptors, the nanoscale distribution of GABAA receptors in the postsynaptic area is a crucial de

201 ively low-affinity gamma2 subunit-containing GABAA receptors in the thalamus, which can contribute to

202 ostsynaptic currents (EPSCs) are followed by GABA(A) receptor-independent outward currents, reflectin

203 R)mutation renders alpha1-subunit containing GABAA receptors insensitive towards benzodiazepines.

204 The rho1 GABA(A) receptor is prominently expressed in the retina

205 The family of GABA(A) receptors is an important drug target group in t

206 munoreactivity for the alpha2 subunit of the GABAA receptor is higher in layers 2/superficial 3 of th

207 larizing inhibition mediated by type A GABA (GABAA) receptors is dependent on chloride extrusion by t

208 th human alpha1beta3gamma2L-a major synaptic GABA(A) receptor isoform-that is functionally reconstitu

209 ype profiles, depending on the extrasynaptic GABAA receptor isoforms targeted.

210 esthetic drugs that modulate the heteromeric GABA(A) receptor, it maintains a rich and multifaceted s

211 ences in the distribution and composition of GABAA receptors may account for distinct effects and sid

212 he postpartum period, the brain's inhibitory GABAA receptors may not recover in time following their

213 Pentameric GABA(A) receptors mediate a large share of CNS inhibitio

214 rent views suggest gamma2 subunit-containing GABA(A) receptors mediate phasic IPSCs while extrasynapt

215 GABA(A) receptors mediate transmission throughout the ce

216 Withdrawal of GABA(A) receptor-mediated inhibition of the RVLM increas

217 molecular layer interneurons (MLIs) through GABA(A) receptor-mediated inhibition.

218 altered mouse line (PC-Deltagamma2) in which GABA(A) receptor-mediated signaling at MLI to Purkinje c

219 ovel role for NO in strengthening inhibitory GABA(A) receptor-mediated transmission in molecular laye

220 Potassium elevations associated to GABAA receptor-mediated population events were confirmed

221 or enabling inhibitory neuronal responses to GABAA receptor-mediated signaling.

222 sporter KCC2 (SLC12A5) tunes the efficacy of GABAA receptor-mediated transmission by regulating the i

223 only a local and limited effect on the rho1 GABAA receptor model system.

224 c coagonists at pentameric alpha1beta3gamma2 GABA(A) receptors, modulating channel activation via fou

225 cued by treatment with a positive allosteric GABAA receptor modulator.

226 and a rational basis for the development of GABA(A) receptor modulators.

227 s able to rescue the deficits in AMPA, NMDA, GABA(A) receptors, mTOR and p-mTOR induced by CORT.

228 Moreover, depressive-like phenotypes of GABAA receptor mutant mice can be reversed by treatment

229 that precise functional genomic analyses of GABA(A) receptor mutations using concatenated constructs

230 sion by systemic administration of an alpha5-GABA(A) receptor negative allosteric modulator, L-655,70

231 eptors expressed in HEK293 cells, and native GABAA receptors of cerebellar granule cells, hippocampal

232 n of dendritic IPSCs isolated after blocking GABAa receptor on the soma.

233 tes increases the expression and activity of GABAA receptors on the dendrites of the cells and that s

234 ates the molecular principles of heteromeric GABA(A) receptor organization and provides a reference f

235 Each GABA(A) receptor pentamer contains two phosphatidylinosi

236 n the beta3(+) and alpha1(-) subunits of the GABAA receptor pentamer was also identified.

237 Infusion of the GABA(A) receptor-positive allosteric modulator Indiplon

238 Importantly, CD is a photoreleasable GABA(A) receptor-positive allosteric modulator that offe

239 is not associated with meaningful changes in GABA(A) receptor potency, mean channel open-time, open p

240 GABA(A) receptor potentiators are commonly used for the

241 basis for the pharmacological modulation of GABA(A) receptors remains largely unknown.

242 ts and mediated by alpha5 subunit-containing GABA(A) receptors rescues both NMDAR activation and syna

243 Cerebellar granule cell GABAA receptor responses to alcohol vary as a function o

244 s, we inactivated the gamma2 subunit gene of GABAA receptors selectively in these neurons (SSTCre:gam

245 ntly decreases the hyper-excitable action of GABAA receptor signaling and restores network homeostati

246 Modulation of the D1/GABAA receptor signaling pathway of ON-cBC dendrites by

247 The blockade of GABA(A) receptors strongly improved the selectivity of t

248 The most frequent GABA(A) receptor subtype is composed of two alpha-, two

249 Compounds that can act on GABAA receptor subtype in a selective manner, without th

250 This GABAA receptor subtype is thought to mediate sedation.

251 nzotriazine, already identified as selective GABAA receptor subtype ligands endowed with anxiolytic-l

252 Continuing our research on GABAA receptor subtype ligands, here is reported the syn

253 of the clinically relevant drugs target all GABA(A) receptor subtypes equally.

254 t it is not clear whether targeting distinct GABA(A) receptor subtypes will have disproportionate ben

255 ding for the gamma-aminobutyric acid type A (GABA(A) ) receptor subunit beta2.

256 itulated the memory deficits and had reduced GABA(A) receptor subunit alpha2 (GABRA2) expression in l

257 ine neurons and the expression of the alpha6 GABA(A) receptor subunit at the mossy fiber-granule cell

258 linked mutation in Gabrg2, a gene encoding a GABA(A) receptor subunit.

259 g on the cell type studied, their respective GABAA receptor subunit compositions, and critically, on

260 Differences in GABAA receptor subunit expression between the human and

261 ith 480 epilepsy-related genes including all GABAA receptor subunit genes (GABRs), and we identified

262 Mutations in GABAA receptor subunit genes are frequently associated w

263 s mediating synaptic transmission, including GABAA receptor subunit genes.

264 and for targeted-ABPP and observed a lack of GABAA receptor subunit protection.

265 Further, expression of an important GABAA receptor subunit, GABAAR alpha1, was significantly

266 gulated in the low pH treatment, including a GABAA receptor subunit.

267 stry, we investigated the distribution of 10 GABA(A) receptor subunits (alpha1, alpha2, alpha3, alpha

268 (i.e. exploratory behavior) and whole-brain GABA(A) receptor subunits (gabra1, gabra2, gabrd, & gabr

269 ome (Scn1a(+/-) ), and in which the alpha(2) GABA(A) receptor subunits are expressed at higher levels

270 We examined GABA(A) receptor subunits GABA(Aalpha1) and GABA(Aalpha2

271 The distribution of GABA(A) receptor subunits in the rhesus monkey was highl

272 s coping style and that expression of select GABA(A) receptor subunits may be one of the underlying m

273 osed fish had altered relative expression of GABA(A) receptor subunits, suggesting that some other st

274 amic principal neurons were found to express GABAA receptor subunits alpha1 , alpha3 , beta2/3 , gamm

275 Here, the expression of GABAA receptor subunits alpha1, alpha2, alpha3, alpha5,

276 regional staining intensity for all positive GABAA receptor subunits from the dorsolateral pole to ve

277 ere performed, and subcellular expression of GABAA receptor subunits was analyzed semiquantitatively.

278 rneurons showed relatively low expression of GABAA receptor subunits.

279 Simulated docking of DCUK-OEt at the GABAA receptor suggested that its binding site may be at

280 s more sensitive to GABA than enhancement by GABAA receptors, suggesting GABAB receptors may be activ

281 have been explored experimentally using the GABA(A) receptor, summarize analytical expressions for a

282 ed the S-SCAM overexpression-induced loss of GABA(A) receptors, supporting that GABAergic synapse los

283 romotes the recruitment and strengthening of GABA(A) receptor synapses via Ca(2+)/calmodulin-dependen

284 tely selective for alpha5-subunit-containing GABA(A) receptors, the derivative SH53d-acid shows super

285 that, in addition to the number of synaptic GABAA receptors, the nanoscale distribution of GABAA rec

286 odulation of gamma-aminobutyric acid type A (GABA(A)) receptors to dampen neuronal activity in the br

287 potentiation of the human alpha1beta2gamma2L GABAA receptor to demonstrate that: 1) curvilinear isobo

288 the Cb-mediated recruitment of gephyrin and GABAA receptors to developing inhibitory postsynapses an

289 properties of recombinant alpha1beta2gamma2L GABAA receptors transiently expressed in HEK293T cells.

290 he potassium-chloride cotransporter KCC2 and GABAA receptors, undergo remarkable fluctuations within

291 icating perhaps increased neuronal matter or GABAA receptor upregulation and inflammatory edema.

292 DCUK-OEt modulation of alpha1beta2gamma2 GABAA receptors was not blocked by flumazenil.

293 Whereas the activation of GABAA receptors was responsible for the direct inhibitio

294 roteins because Nav1.2 channels, but not AIS GABAA receptors, were also endocytosed.

295 hemical technology to individually study the GABA(A) receptor, which specifically expands the toolbox

296 clarifies a Grp94-mediated ERAD pathway for GABAA receptors, which provides a novel way to finely tu

297 mediated by type A gamma-aminobutyric acid (GABAA) receptors, which are Cl(-)-permeable, ligand-gate

298 Many hit compounds modulated human GABA(A) receptors, while others appeared to modulate dif

299 mma2, alpha5beta3gamma2 and alpha1beta3delta GABAA receptors, while having no significant PAM effect

300 this deficit by overexpression of the alpha5-GABA(A) receptor within the ventral hippocampus (vHipp).