ライフサイエンスコーパス: GABA-A receptor

1 he alpha2 beta2 gamma2 subunits of the human GABA-A receptor.

2 DA receptor ion channel and (18)F-GE-194 for GABA-A receptor.

3 the effect was shown to be mediated via the GABA(A) receptor.

4 aria and a potent orthosteric agonist of the GABA(A) receptor.

5 tamate transporters EAAT1 and EAAT2, and the GABA(A) receptor.

6 to the modes of action of these drugs on the GABA(A) receptor.

7 ibits the human alpha (2) beta (3) gamma (2) GABA(A) receptor.

8 that MG is a competitive partial agonist at GABA-A receptors.

9 -Fos induction in the PVH with disruption of GABA-A receptors.

10 artially mediated by insulin action, but not GABA-A receptors.

11 abnormal cerebrospinal fluid potentiation of GABA-A receptors.

12 reversal potential of inhibitory glycine and GABA(A) receptors.

13 ious stimulation of the colon, primarily via GABA(A) receptors.

14 lular stores are necessary for modulation of GABA(A) receptors.

15 ns synaptic inhibition via downregulation of GABA(A) receptors.

16 shed by preventing CaMKII phosphorylation of GABA(A) receptors.

17 ch has focused on studying alpha5-containing GABA(A) receptors.

18 urons to regulate plasticity associated with GABA(A) receptors.

19 reduction in surface levels of glutamate and GABA(A) receptors.

20 acterized at native and selected recombinant GABA(A) receptors.

21 a postsynaptic crosstalk between GABA(B) and GABA(A) receptors.

22 ents indicated the presence of extrasynaptic GABA(A) receptors.

23 atory AMPA receptors (AMPARs) and inhibitory GABA(A) receptors.

24 valent to the benzodiazepine binding site in GABA(A) receptors.

25 property associated with outward rectifying GABA(A) receptors.

26 o the activity-induced dispersal of synaptic GABA(A) receptors.

27 protein (GABARAP) to stabilize cell surface GABA(A) receptors.

28 pha5beta3gamma2 over other alphaxbeta3gamma2 GABA(A) receptors.

29 ogical and pharmacological properties of the GABA(A) receptors.

30 tonic GABA current mediated by extrasynaptic GABA(A) receptors.

31 onses of the gamma-aminobutyric acid type A (GABA(A)) receptor.

32 mprising the gamma-aminobutyric acid type A (GABA(A)) receptor.

33 ent in the brain are the alpha1beta2/3gamma2 GABA(A) receptors(5).

34 lcohol as a positive allosteric modulator of GABA(A) receptors, a decrease in dopamine function, and

35 Thus, GABA(A) receptors activated at synapses were not modulat

36 increases membrane depolarization induced by GABA(A) receptor activation in these neurons.

37 To determine the effect of GABA(A) receptor activation on membrane potential, perfo

38 The effects of gamma-aminobutyric acid (GABA) A receptor activation on physiologic responses dur

39 (2+) buffering, and its sign was inverted by GABA-A receptor activation.

40 was to provide a model-based description of GABA(A) receptor activity under steady-state conditions

41 uced enhancement of gamma-aminobutyric acid (GABA)-A receptor activity was found in patients with IH

42 ats by locally concentrating and releasing a GABA(A) receptor agonist from ultrasound-controlled carr

43 ute treatment with a peripherally restricted GABA(A) receptor agonist that acts directly on mechanose

44 oxypyrazole (4-AHP) analogues of muscimol, a GABA(A) receptor agonist, has been synthesized and pharm

45 PVN inhibition by bilateral injection of the GABA-A receptor agonist muscimol (0.1 nmol in 50 nl).

46 vation or disinhibition, we microinfused the GABA-A receptor agonist muscimol (C4H6N2O2; 62.5, 125, 2

47 tional relationship between delta and gamma2 GABA(A) receptors akin to that of slow NMDA and fast AMP

48 everity of seizures which is correlated with GABA(A) receptor alpha(2) subunit expression.

49 he hypotheses, indicating that loop C of the GABA(A) receptor alpha-subunit is the dominant molecular

50 e defined as a PVBC bouton that overlapped a GABA(A) receptor alpha1 subunit punctum.

51 tamic acid decarboxylase (GAD65), PV and the GABA(A) receptor alpha1 subunit.

52 -1 (~20%) levels, as well as TLR4 binding to GABA(A) receptor alpha2 subunits (~60%) and MyD88 (~40%)

53 associated with increased expression of the GABA(A) receptor alpha2 subunits by 93%, and these chang

54 The alpha5 subunit-containing GABA(A) receptor (alpha5-GABA(A)R) is abundantly express

55 -subunit-containing gamma-aminobutyric acid (GABA)(A) receptors (alpha5-GABARs).

56 g to (i) the orthosteric binding site of the GABA(A) receptor and (ii) the high-affinity GHB binding

57 acterized at native and selected recombinant GABA(A) receptors and GABA transporters.

58 e in newly synthesized cell surface synaptic GABA(A) receptors and is abolished by preventing CaMKII

59 and anesthetic agent that can both activate GABA(A) receptors and potentiate receptor activation eli

60 ) affinity selectivity for alpha5-containing GABA(A) receptors and show atom-level structure predicti

61 of GABA metabolic enzymes and transporters, GABA-A receptors and regulators, and voltage-dependent c

62 the brain tonically activates extrasynaptic GABA(A) receptors, and activity-dependent changes in amb

63 ent agonist at human alpha(1)beta(2)gamma(2) GABA(A) receptors, and in SAR studies substitutions in t

64 ization of synaptic gamma-aminobutyric acid (GABA)A receptors, and withdrawal of benzodiazepines and

65 ts, which typically constitute extrasynaptic GABA-A receptors, and GABA-B R1 and R2 subunits.

66 cating that the REM sleep-inducing effect of GABA(A) receptor antagonism is dependent upon the local

67 the NMDA receptor antagonist MK-801 and the GABA(A) receptor antagonist bicuculline methiodide while

68 tructurally dense (1.64 mcbits/ angstrom(3)) GABA(A) receptor antagonist bilobalide, intermediates en

69 n be mimicked by single microinfusion of the GABA(A) receptor antagonist picrotoxin into the normal a

70 The mutation imparts resistance to the GABA(A) receptor antagonist picrotoxin, allowing verific

71 intra-BLA administration of a low dose of a GABA(A) receptor antagonist, but not an NMDA/AMPA/kainat

72 Gabazine, a gamma-aminobutyric acid type A (GABA(A)) receptor antagonist, has previously been report

73 junctions blocker), control, and picrotoxin (GABA-A receptor antagonist).

74 In line with this, we show that gabazine, a GABA-A receptor antagonist, is antihyperalgesic in prime

75 (2+) transients persist in the presence of a GABA-A receptor antagonist, though the directional tunin

76 Microinjection of GABA(A) receptor antagonists into PnO induces a long las

77 th these findings, it has been reported that GABA(A) receptor antagonists microdialyzed into PnO resu

78 or GABAergic neurotransmission with NMDA or GABA(A) receptor antagonists potently reduced the LC-ind

79 e responsible for the REM sleep induction by GABA(A) receptor antagonists through blocking GABA inhib

80 , the VMR was only consistently increased by GABA(A) receptor antagonists.

81 The effects of steroids on the GABA(A) receptor are typically determined by comparing s

82 Synaptic GABA(A) receptors are alternately exposed to short pulse

83 he inhibitory tone of DGGCs when GABA(B) and GABA(A) receptors are both activated.

84 Structures in which GABA(A) receptors are bound by benzodiazepine-site ligan

85 GABA(A) receptors are composed of five subunits arranged

86 der both physiologic and clinical conditions GABA(A) receptors are exposed to multiple agonists, incl

87 Immobilized GABA(A) receptors are stabilized by binding to FRM-3/EPB

88 Here we show that immobile and diffusing GABA(A) receptors are stabilized by distinct synaptic sc

89 Diffusing GABA(A) receptors are stabilized by the synaptic adhesio

90 Type-A gamma-aminobutyric (GABA(A)) receptors are ligand-gated chloride channels wi

91 Type A gamma-aminobutyric acid (GABA(A)) receptors are pentameric ligand-gated ion chann

92 Previous studies have identified GABA(A) receptors as the primary targets of most anesthe

93 eurons, where it interacts directly with the GABA(A) receptor-associated protein (GABARAP) to stabili

94 Antibodies directed against GABA(A) receptor-associated protein, and the glycine-alp

95 RAPs, in particular gamma-aminobutyric acid (GABA)-A-receptor-associated protein-like 2 (Gabarapl2; a

96 teracting at the NCA site in the pore of the GABA(A) receptor at a location that is overlapping but n

97 ficient per se, for efficient recruitment of GABA(A) receptors at GABAergic synapses in C. elegans Th

98 urons potently inhibit AP Ca(2+) signals via GABA-A receptors at both spines and dendrites.

99 The alpha5 subtype GABA-A receptor availability was indexed using [(11)C]Ro

100 devoid of any intrinsic activity toward the GABA(A) receptor before irradiation.

101 , 5-7, displayed moderate GAT activities and GABA(A) receptor binding affinities in the mid-nanomolar

102 s with the high-affinity GHB and orthosteric GABA(A) receptor binding sites differently and that dist

103 by conductance analysis during nicotinic and GABA(A) receptor blockade.

104 illatory changes, we examined the effects of GABA-A receptor blockade, finding that picrotoxin (PTX)

105 With GABA-A receptors blocked, both iGluSnFR signals and exci

106 were sustained by GABAergic signaling, as a GABA(A) receptor blocker stopped them in 2 of 3 slices.

107 tagonist) or by (2) bicuculline (a preferent GABA(A) receptor blocker), suggesting a GABAergic activa

108 esent cryo-electron microscopy structures of GABA(A) receptors bound to intravenous anaesthetics, ben

109 c analysis suggests that LGC-35 evolved from GABA-A receptors, but the pore-forming domain contains n

110 ation of the concatemeric alpha1beta2gamma2L GABA(A) receptor by combinations of agonists.

111 The study describes modulation of the rho1 GABA(A) receptor by neurosteroids.

112 dy, we analyzed modulation of the human rho1 GABA(A) receptor by several neurosteroids, individually

113 been used to describe the activation of the GABA(A) receptor by the transmitter, GABA, and drugs tha

114 nding isotherms from recombinant alpha1beta3 GABA(A) receptors can be qualitatively predicted using e

115 In nonrhythmic conditions, antagonizing GABA(A) receptors can initiate this synchronization whil

116 Activation of GABA(A) receptors consisting of alpha4, beta2 (or beta3)

117 Native gamma-aminobutyric acid (GABA)A receptors consisting of alpha4, beta1-3, and delt

118 g mechanism involves membrane-shunting tonic GABA(A) receptor current; it does not have to rely on I(

119 e tonically active and enhance extrasynaptic GABA(A) receptor currents in cerebellar granule cells.

120 edominantly express beta2-subunit-containing GABA(A) receptors; deletion of the beta2-subunit ablates

121 GABA currents and currents activated by the GABA(A) receptor delta subunit-selective agonist THIP (1

122 uding extrasynaptic delta subunit-containing GABA(A) receptors (delta-GABA(A)Rs) that mediate tonic i

123 BAergic activity at delta subunit-containing GABA(A) receptors (delta-GABA(A)Rs).

124 ions of interest, we found no differences in GABA(A) receptor densities between ASD and TD groups.

125 We measured both total GABA(A) receptor densities by using [(18)F]flumazenil po

126 eous acquisitions of GABA concentrations and GABA(A) receptor densities can identify objective molecu

127 uggesting a progressive decrease in thalamic GABA-A receptor density.

128 Low-threshold cutaneous afferents evoke a GABA(A)-receptor-dependent form of PSI that inhibits sim

129 The STP(GABA) led to a minutes-long GABA(A)receptor-dependent increase in spike frequency in

130 nd mature N-methyl-d-aspartate, kainate, and GABA(A) receptors did not reach the synapse, whereas mat

131 cally inhibits dopamine release, but whether GABA-A receptors directly modulate transmission or act i

132 quantify and predict the loss of activatable GABA(A) receptors due to desensitization in the presence

133 Prolonged activation of GABA(A) receptors during epileptiform bursts may even in

134 rrecting the disrupted driving force through GABA(A) receptors during the CP in cortical neurons rest

135 tamate receptor and gamma-aminobutyric acid (GABA)-A receptor during progression of brain pathology i

136 e phenotypic spectrum is comparable to other GABA(A) receptor-encoding genes.

137 tested using concatemeric alpha1beta2gamma2 GABA(A) receptors expressed in Xenopus oocytes.

138 results suggest a complex interplay between GABA(A) receptor expression by spinally projecting C1 an

139 absence of both MADD-4 and NRX-1, NLG-1 and GABA(A) receptors fail to cluster, and GABAergic synapti

140 rated light-sensitive versions of the entire GABA(A) receptor family.

141 GABA(A) receptors form Cl(-) permeable channels that med

142 ion dipicrylamine (DPA) negatively regulates GABA(A) receptor function by a mechanism indistinguishab

143 The modulation of GABA(A) receptor function by postsynaptic GABA(B) recept

144 allows scalable interrogation of endogenous GABA(A) receptor function with high spatial, temporal, a

145 of gamma-aminobutyric acid type A receptor (GABA(A)) receptor function.

146 Furthermore, disruption of GABA-A receptor function in the PVH also reduced postwea

147 vity of interneurons and the distribution of GABA(A) receptor (GABA(A) R) subtypes, distinguished by

148 steroid-binding sites in the alpha(1)beta(3) GABA(A) receptor (GABA(A)R) contributes to neurosteroid

149 ering of seizures at room temperature by the GABA(A) receptor (GABA(A)R) positive allosteric modulato

150 ndently, of retinal environment age on their GABA(A) receptor (GABA(A)R) responses, elicited by musci

151 4 and 11 during pharmacological blockade of GABA(A) receptors (GABA(A) Rs) and/or glycine receptors

152 tameric ligand-gated ion channels, including GABA(A) receptors (GABA(A)R) and nicotinic acetylcholine

153 Whereas both GABA(A) receptors (GABA(A)Rs) and glycine receptors (Gly

154 anule cell axons through local activation of GABA(A) receptors (GABA(A)Rs) and the soma through elect

155 GABA(A) receptors (GABA(A)Rs) are pentameric ligand-gate

156 GABA(A) receptors (GABA(A)Rs) are profoundly important f

157 GABA(A) receptors (GABA(A)Rs) are targets for important

158 ion by stabilizing gamma2 subunit-containing GABA(A) receptors (GABA(A)Rs) at the cell surface, leadi

159 een postsynaptic NMDA receptors (NMDARs) and GABA(A) receptors (GABA(A)Rs) contributes to the excitat

160 GABAergic signaling through GABA(A) receptors (GABA(A)Rs) expressed in the oligodend

161 Alterations of postsynaptic GABA(A) receptors (GABA(A)Rs) likely underlie the impact

162 Behaviorally, loss of either GABA(A) receptors (GABA(A)Rs) or NMDA receptors (NMDARs)

163 Activation of GABA(A) receptors (GABA(A)Rs) produces two forms of inhi

164 Oligodendrocytes (OLs) express functional GABA(A) receptors (GABA(A)Rs) that are activated by GABA

165 Microiontophoretic activation of GABA(A) receptors (GABA(A)Rs) with GABA or with the sele

166 ent positive allosteric modulators (PAMs) of GABA(A) receptors (GABA(A)Rs) with in vivo anesthetic, a

167 n in the brain is mediated by GABA acting on GABA(A) receptors (GABA(A)Rs), which provides inhibitory

168 predominantly via synaptic alpha1beta2gamma2 GABA(A) receptors (GABA(A)Rs).

169 terminant of gamma-aminobutyric acid type A (GABA(A)) receptor (GABA(A)R)-mediated inhibition and cyt

170 GABA-A receptors (GABA-ARs) are typically expressed at s

171 ubunits, which typically constitute synaptic GABA-A receptors, GABA-A alpha4 and delta subunits, whic

172 ht that inhibitory neurotransmission through GABA-A receptors (GABAAR) modulates early TEPs (<50 ms a

173 Tonic inhibition mediated by extrasynaptic GABA(A) receptors (GABARs) sensing ambient levels of GAB

174 Expression of the pi subunit of the GABA(A) receptor (GABRP) is associated with the BLBC/TN

175 ng with vesicular amino acid transporter and GABA(A)-receptor gamma2 subunit immunoreactivities.

176 bits BMAL1-controlled rhythmic expression of GABA-A receptor gamma2 subunit, and dampening rhythmicit

177 s, the closed and desensitized states of the GABA(A) receptor gating cycle, and the basis for alloste

178 The drug also caused changes in GABA(A) receptor gating properties in the vHipp with res

179 A (gamma-aminobutyric acid) to extrasynaptic GABA(A) receptors generates tonic inhibition that acts a

180 fect is mediated by the loss of postsynaptic GABA(A) receptors, gephyrin, and neuroligin 2 and does n

181 No caged allosteric modulators of the GABA(A) receptor have been reported so far; to introduce

182 e accurate structural models for heteromeric GABA(A) receptors have been hampered by the use of engin

183 ceptor docking in an alpha(1)beta(2)gamma(2) GABA(A) receptor homology model along with the obtained

184 tion for a human membrane protein, the beta3 GABA(A) receptor homopentamer(3).

185 hat selective inactivation of GABAB, but not GABA(A), receptors impairs firing rate homeostasis by di

186 the blockade of both glutamatergic NMDA and GABA(A) receptors improved neuronal selectivity of delay

187 ich the full-length human alpha1beta3gamma2L GABA(A) receptor in lipid nanodiscs is bound to the chan

188 he central nervous system, alpha5-containing GABA(A) receptors in airway smooth muscles are considere

189 Structures of GABA(A) receptors in complex with the anaesthetics pheno

190 t for a clathrin-mediated internalization of GABA(A) receptors in expression of LTD(GABA).

191 nses in MSNs were primarily mediated through GABA(A) receptors in feedforward inhibition.

192 from the zolpidem sensitivity, postsynaptic GABA(A) receptors in NG2 cells contain the gamma2-subuni

193 olecular techniques to analyze properties of GABA(A) receptors in NG2 cells of the juvenile mouse hip

194 tions, a major risk factor for CVD, increase GABA(A) receptors in RVLM, including its rostral extensi

195 as been used to evaluate the distribution of GABA(A) receptors in the brain, and studies of modulatio

196 The majority of GABA(A) receptors in the mammalian brain consist of two

197 steric modulator of gamma-aminobutyric acid (GABA)-A receptors in cerebrospinal fluid.

198 We monitored changes in NMDA receptor and GABA-A receptor in a clinically relevant model of trauma

199 ction of changes in active NMDA receptor and GABA-A receptor in the injured brain.

200 Three populations of GABA-A receptors in astrocytes were identified: classic

201 In addition, disruption of GABA-A receptors in the PVH reduced feeding.

202 eptors enhance the function of extrasynaptic GABA(A) receptors, including delta subunit-containing re

203 Negative allosteric modulators of GABA-A receptors, including clarithromycin, have been re

204 ostsynaptic currents (EPSCs) are followed by GABA(A) receptor-independent outward currents, reflectin

205 tracellular applications of p4, a blocker of GABA(A) receptor internalization.

206 ble with a beta subunit to form a subtype of GABA(A) receptor involved in generating the "tonic" outw

207 The rho1 GABA(A) receptor is prominently expressed in the retina

208 The family of GABA(A) receptors is an important drug target group in t

209 th human alpha1beta3gamma2L-a major synaptic GABA(A) receptor isoform-that is functionally reconstitu

210 esthetic drugs that modulate the heteromeric GABA(A) receptor, it maintains a rich and multifaceted s

211 We hypothesize that GABA(A) receptors located on cholinergic boutons in the

212 Pentameric GABA(A) receptors mediate a large share of CNS inhibitio

213 rent views suggest gamma2 subunit-containing GABA(A) receptors mediate phasic IPSCs while extrasynapt

214 GABA(A) receptors mediate transmission throughout the ce

215 xes to assess corticospinal excitability and GABA-A-receptor mediated short-latency intracortical inh

216 Tonic inhibitory GABA(A) receptor-mediated currents are observed in numer

217 The synchronized GABA(A) receptor-mediated currents give rise to a major

218 The GABA(A) receptor-mediated hyperpolarization activates I(

219 ehensive optogenetic toolkit for controlling GABA(A) receptor-mediated inhibition in the brain.

220 Withdrawal of GABA(A) receptor-mediated inhibition of the RVLM increas

221 molecular layer interneurons (MLIs) through GABA(A) receptor-mediated inhibition.

222 edominantly, if not exclusively, spontaneous GABA(A) receptor-mediated input, the cellular sources or

223 GABA(A) receptor-mediated IPSCs evoked by electrical or

224 om layer V pyramidal cells, and monosynaptic GABA(A) receptor-mediated IPSCs were elicited.

225 fically expressed in DAergic SACs produced a GABA(A) receptor-mediated monosynaptic inhibitory respon

226 altered mouse line (PC-Deltagamma2) in which GABA(A) receptor-mediated signaling at MLI to Purkinje c

227 eroidogenesis, which leads to an increase in GABA(A) receptor-mediated synaptic inhibition in lamina

228 ovel role for NO in strengthening inhibitory GABA(A) receptor-mediated transmission in molecular laye

229 GABA-A receptors mediating synaptic or extrasynaptic tra

230 c coagonists at pentameric alpha1beta3gamma2 GABA(A) receptors, modulating channel activation via fou

231 Thus, we reveal the mechanisms of GABA-A receptor modulation of dopamine release and provi

232 and a rational basis for the development of GABA(A) receptor modulators.

233 s able to rescue the deficits in AMPA, NMDA, GABA(A) receptors, mTOR and p-mTOR induced by CORT.

234 that precise functional genomic analyses of GABA(A) receptor mutations using concatenated constructs

235 sion by systemic administration of an alpha5-GABA(A) receptor negative allosteric modulator, L-655,70

236 conferred a high Zn(2)(+) sensitivity to the GABA(A) receptors of NG2 cells.

237 and perforated-patch recordings to test for GABA-A receptors on the main dopaminergic neuron axons a

238 predominantly generated by GABA-independent GABA(A) receptor openings.

239 ates the molecular principles of heteromeric GABA(A) receptor organization and provides a reference f

240 Each GABA(A) receptor pentamer contains two phosphatidylinosi

241 GABA(A) receptors play a crucial role in the actions of

242 Infusion of the GABA(A) receptor-positive allosteric modulator Indiplon

243 Importantly, CD is a photoreleasable GABA(A) receptor-positive allosteric modulator that offe

244 recent modeling study of the beta3 homomeric GABA(A) receptor postulated a high-affinity propofol bin

245 is not associated with meaningful changes in GABA(A) receptor potency, mean channel open-time, open p

246 Xenopus oocyte assay, we found an absence of GABA-A receptor potentiation with CSF from patients with

247 GABA(A) receptor potentiators are commonly used for the

248 d ion channel (GLIC), a bacterial homolog of GABA(A) receptors, provided an opportunity to explore st

249 imal model the effect of chronic infusion of GABA(A) receptor (R) agonist and antagonist in the vesti

250 erologously expressed rat alpha1beta2gamma2L GABA(A) receptors, ranging from essentially inert to hig

251 basis for the pharmacological modulation of GABA(A) receptors remains largely unknown.

252 ts and mediated by alpha5 subunit-containing GABA(A) receptors rescues both NMDAR activation and syna

253 The blockade of GABA(A) receptors strongly improved the selectivity of t

254 We first show that GABA-A receptors strongly inhibit action potential (AP)-

255 The most frequent GABA(A) receptor subtype is composed of two alpha-, two

256 of the clinically relevant drugs target all GABA(A) receptor subtypes equally.

257 t it is not clear whether targeting distinct GABA(A) receptor subtypes will have disproportionate ben

258 ding for the gamma-aminobutyric acid type A (GABA(A) ) receptor subunit beta2.

259 itulated the memory deficits and had reduced GABA(A) receptor subunit alpha2 (GABRA2) expression in l

260 ine neurons and the expression of the alpha6 GABA(A) receptor subunit at the mossy fiber-granule cell

261 is plasticity, demonstrating its reliance on GABA(A) receptor subunit composition.

262 n which the "photoswitch-ready" version of a GABA(A) receptor subunit genomically replaces its wild-t

263 ic boutons were found to be colocalized with GABA(A) receptor subunit protein gamma2.

264 Here we investigate the input and GABA(A) receptor subunit specificity of inhibitory synap

265 Our results reveal a novel GABA(A) receptor subunit- and input-specific form of inh

266 we found that CRF1 neurons exhibit an alpha1 GABA(A) receptor subunit-mediated tonic conductance that

267 linked mutation in Gabrg2, a gene encoding a GABA(A) receptor subunit.

268 The postsynaptic gamma2-GABA(A)-receptor subunit and the presynaptic vesicular i

269 stry, we investigated the distribution of 10 GABA(A) receptor subunits (alpha1, alpha2, alpha3, alpha

270 (i.e. exploratory behavior) and whole-brain GABA(A) receptor subunits (gabra1, gabra2, gabrd, & gabr

271 ome (Scn1a(+/-) ), and in which the alpha(2) GABA(A) receptor subunits are expressed at higher levels

272 We examined GABA(A) receptor subunits GABA(Aalpha1) and GABA(Aalpha2

273 The distribution of GABA(A) receptor subunits in the rhesus monkey was highl

274 s coping style and that expression of select GABA(A) receptor subunits may be one of the underlying m

275 osed fish had altered relative expression of GABA(A) receptor subunits, suggesting that some other st

276 s and the complementary genetically modified GABA(A) receptor subunits.

277 ole of putative trafficking sequences in two GABA(A) receptor subunits: alpha4 and delta.

278 A levels of 7 of the most commonly expressed GABA-A receptor subunits, and both GABA-B receptor subun

279 have been explored experimentally using the GABA(A) receptor, summarize analytical expressions for a

280 ed the S-SCAM overexpression-induced loss of GABA(A) receptors, supporting that GABAergic synapse los

281 PKA-AKAP-CaN complex is uniquely situated at GABA(A) receptor synapses in VTA DA neurons to regulate

282 romotes the recruitment and strengthening of GABA(A) receptor synapses via Ca(2+)/calmodulin-dependen

283 tely selective for alpha5-subunit-containing GABA(A) receptors, the derivative SH53d-acid shows super

284 nes modulate gamma-aminobutyric acid type A (GABA(A)) receptors throughout the brain.

285 odulation of gamma-aminobutyric acid type A (GABA(A)) receptors to dampen neuronal activity in the br

286 Cortical interneurons activate GABA-A receptors to rapidly control electrical and bioch

287 R neurons recruit both GABA and GABA-A receptors to their axon terminals in the EB, and

288 Yet, blockade of the GABA(A) receptors transforms GDPs to epileptiform discha

289 tsynapses and is required for clustering the GABA(A) receptor UNC-49.

290 vity for alpha(1)beta(2)gamma(2) over rho(1) GABA(A) receptors was observed for the 5-chloro, 5-bromo

291 interaction between postsynaptic GABA(B) and GABA(A) receptors, we recorded GABA(A) currents elicited

292 gamma-Aminobutyric acid (GABA)A receptors were blocked by bicuculline.

293 Clusters of GABA-A receptors were distributed in the perinuclear spa

294 n alpha1 beta2 gamma2 or alpha2 beta2 gamma2 GABA-A receptors were recorded in response to 6 successi

295 hemical technology to individually study the GABA(A) receptor, which specifically expands the toolbox

296 Many hit compounds modulated human GABA(A) receptors, while others appeared to modulate dif

297 We conclude that activation of GABA A receptors with alprazolam can result in widesprea

298 dent stimulation of gamma-aminobutyric acid (GABA) A receptors with the benzodiazepine alprazolam can

299 this deficit by overexpression of the alpha5-GABA(A) receptor within the ventral hippocampus (vHipp).

300 s have shown that this delay is dependent on GABA(A) receptors within the LGN.