ライフサイエンスコーパス: GATA factor

1 on of pannier, a cardiogenic gene encoding a Gata factor.

2 X17CNXC zinc fingers typical of a vertebrate GATA factor.

3 ) and the C-terminal zinc finger of the same GATA factor.

4 ied by the activity of the divergent MED-1,2 GATA factors.

5 tors, the hypoxia-regulated factor HIF1, and GATA factors.

6 ells can be manipulated by the expression of GATA factors.

7 x5/Dlx6 function, it may require one or more GATA factors.

8 binding to DNA and physical association with GATA factors.

9 regulators, Mix-like paired-homeodomain and GATA factors.

10 evelopment through physical interaction with GATA factors.

11 transcriptional activation mediated by other GATA factors.

12 at found with the vertebrate two zinc finger GATA factors.

13 e specification of hematopoietic mesoderm by GATA factors.

14 at the seventh position of the Zn finger of GATA factors.

15 with the differentiation-promoting action of GATA factors.

16 we summarize the current knowledge of plant GATA factors.

17 motifs for RUNX factors that cooperate with GATA factors.

18 ltipotent LaTPs upon conditional deletion of GATA factors.

19 essing the expression of stem cell-promoting GATA factors.

20 fect is mediated in part by interaction with GATA factors.

21 LISM-INVOLVED (GNC) and CYTOKININ-RESPONSIVE GATA FACTOR 1 (CGA1) act downstream of both light and ph

22 Here we report the identification of a GATA factor (AaGATAa) that is synthesized after a blood

23 However, a GATA factor (AaGATAr) likely acts as a repressor, preven

24 A novel GATA factor (AaGATAr) that recognizes GATA binding motif

25 h anemia resolution, involving repression of GATA factor-accessible regions and activation of ETS fac

26 previously shown that the MED-1,2 divergent GATA factors act apparently zygotically to specify the f

27 Our findings indicate that GATA factors act sequentially to regulate lineage determ

28 genetic and molecular analysis that the two GATA factors act upstream from the flowering time regula

29 GATA factors activate expression of nitrogen catabolic p

30 Friend of GATA (FOG) proteins regulate GATA factor-activated gene transcription.

31 e show how integration of Bmp4 signaling and Gata factor activity controls the progression of hematop

32 gene expression through their modulation of GATA factor activity.

33 GATA factors also contribute to heart formation indirect

34 demonstrate that PBP interacts with all five GATA factors analyzed, GATA-1, GATA-2, GATA-3, GATA-4, a

35 x between the DNA binding domain of a fungal GATA factor and a 13 base-pair oligonucleotide containin

36 This work establishes a link between a GATA factor and inflammatory genes, mechanistic insights

37 Several lines of evidence suggested that GATA factors and AR act cooperatively to activate Pp tra

38 ctors share highly specific association with GATA factors and are substantially interchangeable with

39 n of mouse embryonic stem cells deficient of GATA factors and conclude that GATA-4 is required for ES

40 in tumor cells, suggesting that the loss of GATA factors and dedifferentiation are irreversible proc

41 ior heart field and support a model in which GATA factors and ISL1 serve as the earliest transcriptio

42 This critical link between GATA factors and SNCA may enable therapies designed to l

43 CF3/ATOH1 heterodimers as well as motifs for GATA factors and SP1.

44 is mediated by the C-terminal zinc finger of GATA factors and the homeodomain of HNF-1alpha.

45 nues with Zfh1 activation of Serpent (Srp; a GATA factor), and terminates with Srp activation of U-sh

46 is enhancer has been shown to rely on PDX-1, GATA factors, and Cdx factors for its function.

47 FOG-2 interacts with GATA factors, and interaction of GATA-4 and FOG-2 result

48 portant functional interplay between Ikaros, GATA factors, and the NOTCH signaling pathway in specifi

49 activities of both mammalian and Drosophila GATA factors are controlled in part by physical interact

50 a4 in mouse embryonic pancreas and show that GATA factors are essential regulators of the proliferati

51 ndings demonstrate that the EGL-18 and ELT-6 GATA factors are essential, genetically redundant regula

52 GATA factors are evolutionarily conserved transcription

53 Binding sites for FoxH1, scl, ets and gata factors are found in the zebrafish flk1 endothelial

54 GATA factors are fundamental components of developmental

55 ddition to radiation, we found that specific GATA factors are important for other stressors such as r

56 trophy, demonstrating that cardiac-expressed GATA factors are necessary mediators of this process.

57 Since GATA factors are not chamber-restricted, these findings

58 ypertrophy-associated genes, suggesting that GATA factors are sufficient regulators of cardiomyocyte

59 GATA factors are transcriptional regulatory proteins tha

60 t that elt-5 and -6, adjacent genes encoding GATA factors, are essential for the development of the l

61 e to valine in the DNA-binding domain of the GATA factor AreA results in inability to activate some A

62 To evaluate the requirement of GATA factors as downstream transcriptional mediators of

63 A new gene encoding a novel GATA factor, ASD4, of Neurospora crassa was isolated and

64 We suggest that GATA factors at target sites in chromatin may generally

65 Our results place GATA factors at the top of the transcriptional network h

66 ng gene duplication and modular evolution of GATA factors based upon inclusion of a class IV zinc fin

67 ese factors activate a sequential cascade of GATA factors, beginning with their immediate targets, th

68 Both GATA factors bind the PU.1/Sfpi1 gene at 2 highly conser

69 Although hematopoietic Gata factors bind with Scl to both activated and repress

70 t-expressed genes possess a preponderance of GATA factor binding sites and one GATA factor, ELT-2, fu

71 Two highly conserved consensus GATA factor binding sites within the 275 bp region inter

72 Analysis of GATA factor binding to additional loci also revealed FOG

73 ELT-2 interacted with the GATA factor-binding motif in vitro and was also capable

74 tors regulate GnRH transcription through two GATA factor-binding motifs that occur in a tandem repeat

75 The GATA factor-binding region exhibited cell-type-specific

76 oform accounts for about half of the nuclear GATA-factor-binding activity in the endoderm.

77 in animals and fungi and are referred to as GATA factors by virtue of their affinity for promoter el

78 scriptional regulators, including Sp1, AP-2, GATA factors, c-Myb, and NF-IL-6.

79 njection ventrally of a dominant-interfering GATA factor (called G2en) induced the formation of secon

80 Thus, GATA factors can function in ESC derivatives upstream of

81 We demonstrate that GATA factors can interact with Gli factors and can recru

82 of a single transcription factor, the ELT-7 GATA factor, can convert the identity of fully different

83 ditional input from POP-1/TCF, activates the GATA factor cascade MED-1,2->END-1,3->ELT-2,7.

84 similar to that of vertebrates but only one GATA factor, Ci-GATAa, is expressed in the heart progeni

85 e element-binding protein pathways and other Gata factors, compared with Gata2-dependent HPCs.

86 These results indicate that dispersed GATA factor complexes function via long-range chromatin

87 GATA factors constitute a family of transcriptional regu

88 GATA-1 and other vertebrate GATA factors contain a DNA binding domain composed of tw

89 the potential for a regulatory loop in which GATA factors control the expression of their partner pro

90 rated micro RNA expression and function into GATA factor coordinated networks and provided mechanisti

91 The GATA factor-deleted multipotent progenitors were unable

92 ies establish a transcriptional hierarchy of Gata factor dependence during hematopoiesis and demonstr

93 of these and previous reports, we infer that GATA factor dependence is a critical aspect of FOG prote

94 evealed unique +9.5 site activity to mediate GATA factor-dependent chromatin structural transitions.

95 erable progress has been made in elucidating GATA factor-dependent genetic networks that control bloo

96 erable progress has been made in elucidating GATA factor-dependent genetic networks that control red

97 he Friend of GATA (FOG) coregulator mediates GATA factor-dependent transcription is unknown.

98 ference to poor ones (proline) by repressing GATA factor-dependent transcription of the genes needed

99 In trophoblast progenitors, GATA factors directly regulate BMP4, Nodal and Wnt signa

100 rative bioinformatics analyses revealed that GATA factors directly regulate hundreds of common genes

101 dHAND as a direct transcriptional target of GATA factors during right ventricle development.

102 In line with the essential role of GATA factors, ectopic expression of miR-27a or miR-24 pr

103 The second class truncates the GATA factor either within or upstream of the putative Le

104 Moreover, a GATA factor, either GATA-1 or GATA-2, is required to ini

105 derance of GATA factor binding sites and one GATA factor, ELT-2, fulfills the expected characteristic

106 We have discovered a second gut-specific GATA factor, ELT-7, that profoundly synergizes with ELT-

107 eplace the complete set of endoderm-specific GATA factors: END-1, END-3, ELT-7 and (the probably non-

108 ntaining transcriptional regulators known as GATA-factors ensures efficient utilization of available

109 partially redundant, adjacent genes encoding GATA factors essential for viability, seam cell developm

110 chanisms underlying this restriction and how GATA factors establish genetic networks, we used ChIP-se

111 GATA factors establish transcriptional networks that con

112 cantly, only NIT2, of the several Neurospora GATA factors examined, interacts with NIT4.

113 This work shows that a GATA factor exchange reconfigures higher-order chromatin

114 scriptional regulators and is the only known GATA factor expressed in the distal epithelium of the lu

115 we have demonstrated that down-regulation of GATA factor expression leads to dedifferentiation.

116 lasmids with wild-type and dominant negative GATA factor expression vectors demonstrated that both GA

117 Restoration of GATA factors expression by ectopic transfection suppress

118 ng that the MEDs are atypical members of the GATA factor family that do not recognize GATA sequences.

119 SRE is a member of the GATA factor family, which is comprised of transcription

120 e controlled by MED-1 and -2, members of the GATA factor family.

121 c-finger/basic domains characteristic of the GATA factor family.

122 elucidated mechanisms by which FOGs regulate GATA factor function and discuss how these factors use t

123 Finally, a functional role for GATA factor function in alveolar epithelial type 1 cell

124 lation is leukemogenic, and its influence on GATA factor function is unknown, this mechanistic link h

125 modifying enzyme mediates cell-type-specific GATA factor function.

126 at it acts as a transcriptional repressor of GATA factor function.

127 ive to consider mechanisms underlying normal GATA factor function/regulation and how dissecting such

128 n a genome wide scale that the hematopoietic GATA factors GATA-1 and GATA-2 bind overlapping sets of

129 ion directly at promoters, the hematopoietic GATA factors GATA-1 and GATA-2 often assemble dispersed

130 The hematopoietic GATA factors GATA-1 and GATA-2, which have distinct and

131 Herein, we discuss how the hematopoietic GATA factors (GATA-1-3) function via a battery of mechan

132 In this study, we report that a heterologous GATA factor, GATA-4, was competent in supporting the dev

133 We also demonstrate that a closely related GATA factor, GATA4, is expressed transiently in the preh

134 oensis and C. monodelphis orthologues of the GATA factor gene elt-3 are expressed in the early E line

135 Our experiments also demonstrate that GATA factor gene expression is highly regulated by the G

136 In addition, the GATA factor gene pannier (pnr) and the homeobox gene tin

137 The GATA factor gene pannier is similarly expressed in the d

138 ta support the contention that regulation of GATA-factor gene expression is tightly and dynamically c

139 In Drosophila melanogaster, five different GATA factor genes (pannier, serpent, grain, GATAd and GA

140 is, we identified the functionally redundant GATA factor genes egl-18 and elt-6 as Wnt pathway target

141 GATA5, the only one of the six vertebrate GATA factor genes not yet inactivated in mice, is expres

142 laps with but is distinct from that of other GATA factor genes.

143 Ure2, the protein that negatively regulates GATA factor (Gln3, Gat1)-mediated transcription in Sacch

144 charomyces cerevisiae requires activation by GATA factor Gln3p or Nil1p and is prevented by the prese

145 y does not interfere with the binding of the GATA factor Gln3p to GATAAG sites but acts directly on G

146 ger region highly homologous to those of the GATA factors Gln3p and Nil1p as an antagonist of Nil1p a

147 f a cross-repressive interaction between the GATA factors GNC and GNL and the MADS box transcription

148 Here, we show that the GATA factor HANABA TARANU (HAN) is required to position

149 The END-1 GATA factor has been implicated in specifying endoderm i

150 n Drosophila, the existence of a cardiogenic GATA factor has been implicated through the analysis of

151 As GATA factors have been implicated in endoderm developmen

152 Both Ets and Gata factors have been shown to have important roles in

153 Although vertebrate GATA factors have two highly conserved zinc finger motif

154 Several GATA factors have two promoters directing distinct tissu

155 GAT1 of Candida albicans encodes a GATA-factor homologous to the AREA protein of Aspergillu

156 ily conserved domain that determines B-class GATA factor identity and provides a further subclassific

157 servations identify GATA6 as the predominant GATA factor in the maintenance of endodermal gene expres

158 NF-kappaB family members in lymphocytes and GATA factors in cardiac cells.

159 The transcriptional targets of the GATA factors in early embryonic development include Disa

160 Finally, we reveal roles for key GATA factors in establishing spatial regulatory state do

161 of late endoderm development, but a role for GATA factors in establishing the endoderm is unknown.

162 Our data highlight a novel role for GATA factors in fine tuning Notch signaling during intes

163 The roles of scl, ets and gata factors in hemangioblasts have been well defined, b

164 o participate in differentiation mediated by GATA factors in several tissues.

165 omplexes that are thought to sequester these GATA factors in the cytoplasm of cells cultured in exces

166 sible loss of expression of HNF3 (Foxa2) and GATA factors in the endoderm and the absence of factors

167 Thus, GATA factors in the endoderm are among the first to bind

168 for heart development and acts downstream of GATA factors in the pre-cardiac mesoderm to specify line

169 Herein, we analyzed the role of several GATA factors in the regulation of the erythropoietin gen

170 e first direct demonstration of a target for GATA factors in the vertebrate intestinal epithelium.

171 eracts specifically with the amino finger of GATA factors in the yeast two-hybrid system and in mamma

172 2 in hematopoietic cells are not occupied by GATA factors in trophoblast cells.

173 omous roles performed by multiple, redundant GATA factors in vertebrate cardiogenesis.

174 heart function and redundancy among various GATA factors in vertebrates.

175 sites within the 275 bp region interact with GATA factors in vitro.

176 suggesting that FOG proteins might act in a GATA factor-independent manner.

177 rker genes in animal cap assays, while other GATA factors induce these genes only weakly, if at all.

178 GATA factors interact with simple DNA motifs (WGATAR) to

179 ing modes on the affinity and specificity of GATA factors is discussed.

180 rm cells to show that a DNA-binding site for GATA factors is occupied on a liver-specific, transcript

181 The activity of GATA factors is regulated, in part, at the level of prot

182 attern, indicating that a normal function of GATA factors is to limit the boundary of the Nkx2.5 expr

183 tional program, mediated at least in part by GATA factors, is critical in presumptive foregut endoder

184 Analysis of GATA factors isolated from vertebrates suggests that the

185 These results suggest that GATA factors may function sequentially to regulate endod

186 genitourinary system and suggest that other GATA factors may have functions overlapping those of GAT

187 establish fundamental principles underlying GATA factor mechanisms in chromatin and illustrate a com

188 bioactive lipids as essential components of GATA factor mechanisms to control cell state transitions

189 This article highlights GATA factor mechanistic principles, with a heavy emphasi

190 anisms were also leveraged to discover novel GATA factor-mediated cell regulatory pathways.

191 We also show that the GATA factor-mediated priming of trophoblast progenitors

192 However, our experiments also indicate that GATA factors might normally antagonize transcription of

193 Studies with GATA factor mutants and novel chimeric GATA factors prov

194 In addition, elt-3, which encodes another GATA factor normally expressed in non-seam epidermis, is

195 We found that knockdown of the GATA factors not only alters the expression of genes hav

196 GATA factors occupied loci encoding multiple components

197 These results demonstrate that GATA factors occupy a central position between canonical

198 However, the precise impact of GATA factors on vertebrate cardiogenesis is masked by fu

199 at are independent of those regulated by the GATA factors or TAL1.

200 GATA factors orchestrate hematopoiesis via multistep tra

201 We also identified the GATA factor pannier (pnr) as a downstream target of Stat

202 The GATA factor Pannier (Pnr) is required for eye and heart

203 ring the regulation of nmr, we find that the GATA factor Pannier is essential for cardiac expression,

204 The homeodomain protein Tinman and the GATA factors Pannier and Serpent directly activate Hand

205 of Friend of GATA proteins and the role that GATA factors play during cell fate choice, these factors

206 These observations suggest that GATA factors positively regulate slow MyHC 3 gene expres

207 t assembly of a protein complex containing a GATA-factor, presumably GATA-1 or GATA-2, is critical to

208 with GATA factor mutants and novel chimeric GATA factors provided evidence that both GATA-1 and GATA

209 In order to test whether GATA factors regulated TTF-1 gene transcription, GATA-5

210 ver, accumulating evidence now suggests that GATA factor regulation may occur by two separate pathway

211 ating that these genes are direct targets of GATA factor regulation.

212 eases during normal aging, and both of these GATA factors repress expression of elt-3, which shows a

213 derm differentiation, including a cascade of GATA factors required for development and maintenance of

214 els determine the threshold concentration of GATA factors required for PrE-like differentiation, and

215 ith the Pp in vitro, (iii) overexpression of GATA factors rescued expression from mutant Pp construct

216 entation of signals calling for cessation of GATA factor sequestration in the cytoplasm.

217 on occurs through specific expression of the GATA factor Serpent (Srp) in the lymph-gland primordium.

218 The GATA factor Serpent (Srp) is essential for hh activation

219 The GATA factor Serpent (Srp) is required for hemocyte precu

220 Here, we demonstrate that GATA factor Serpent (Srp) plays an indispensable role in

221 rough Ush interaction with the hematopoietic GATA factor Serpent (Srp).

222 The Drosophila GATA factor Serpent interacts with the RUNX factor Lozen

223 mbryogenesis and larval development, and the GATA factor Serpent is essential for Ush embryonic expre

224 g proteins, Dorsal, Dif, and Relish, and the GATA factor Serpent.

225 es overlapped significantly with that of the GATA factor Serpent.

226 The GATA factor, Serpent, directly regulated the activity of

227 , or chick embryos depleted specifically for GATA factors, show in addition abnormal foregut developm

228 URE-BF appears to interact with a GATA factor, since formation of the URE-BF complex can b

229 pathway, including positive feedback loops, GATA factors, SoxB, Brachyury and a previously underemph

230 We report that the MED-1 and -2 GATA factors specify the entire fate of EMS, which other

231 hromatin sites, we propose that differential GATA factor stability is an important determinant of chr

232 ry of mechanistic permutations, which can be GATA factor subtype, cell type, and locus specific.

233 Other cardiovascular tissue-restricted GATA factors, such as GATA-5 and GATA-6, were equivalent

234 both Gata1 and Gata2, or independent of both Gata factors, suggesting that multiple pathways regulate

235 This is followed by genome-wide GATA factor switching that mediates further induction of

236 ults indicate that FOG-1 is a determinant of GATA factor target gene sensitivity by either facilitati

237 re identify a novel small-molecule-activated GATA factor that is required to regulate the cell type-s

238 ine, as well as to overexpression of the two GATA factors that are normally involved in intestinal di

239 These data suggest that two GATA factors that are required for seam cell specificati

240 One mode involves cooperative binding by two GATA factors that interact with each other through prote

241 These results indicate that similar to other GATA factors, the GATA-3 gene can be controlled by two p

242 r gene expression is highly regulated by the GATA factors themselves in an interdependent manner.

243 or negative coregulators that cooperate with GATA factors to control right ventricular-specific gene

244 vidual contributions of the three vertebrate GATA factors to endoderm formation have been unclear.

245 FOG-like proteins are corepressors that link GATA factors to histone deacetylation and nucleosome rem

246 nt, indicating differential contributions of GATA factors to pancreas formation.

247 The capacity of related GATA factors to promote cardiogenesis is untested.

248 In contrast, FOG1 antagonizes the ability of GATA factors to promote mast cell (MC) development.

249 Friend of GATA proteins interact with GATA factors to regulate development in a variety of tis

250 Knockdown of FOG1 reverses the ability of GATA factors to repress Gli1 expression.

251 ed by anthracyclines, the ability of ectopic GATA factors to rescue anthracycline-induced apoptosis w

252 The discovery of the GATA binding protein (GATA factor) transcription factor family revolutionized

253 FOGs can both facilitate and antagonize GATA factor transcriptional regulation depending on the

254 regulation of GATA-2, an essential mast cell GATA factor, via switching of GATA-1 for GATA-2 at a key

255 ave shown that the combined absence of these GATA factors virtually ablates primitive erythroid cell

256 Induction of HNF3beta by all three GATA factors was abolished when protein synthesis was in

257 Loss of GATA factors was also found in an in vitro model for spo

258 Altered expression of GATA factors was found and proposed as the underlying me

259 5, a target of the MED-1 and MED-2 divergent GATA factors, was previously found to result in a profou

260 In seeking additional GATA factors, we have cloned areB, which was originally

261 d differentiation can be replaced by another GATA-factor, we generated a knock-in mutation of the GAT

262 All three GATA factors were induced by activin, although GATA4 and

263 Multiple binding sites for PDX-1 and GATA factors were previously identified within the appro

264 nsidering control of the nitrogen-responsive GATA factors when studying the regulation of the protein

265 Neurospora possesses at least five different GATA factors which control different areas of cellular f

266 nal signaling regulates the translation of a GATA factor, which is the specific transcriptional activ

267 C4-type zinc finger to those of other known GATA factors, which recognize the consensus HGATAR.

268 y increasing the expression of GATA-binding (Gata) factors, which suppressed expression of the microR

269 otein-protein interactions of the individual GATA factors with additional pathway-specific regulatory

270 with previous studies linking regulation by GATA factors with c-Jun and BRG1, provides genome-wide e

271 mma transcriptional activity, interaction of GATA factors with C/EBP is necessary for their ability t

272 eable and interact with different endodermal GATA factors with only modest differences in affinity.

273 Our results demonstrated that, unlike the GATA factors, ZFPM1 is not essential for the early diffe

274 Multiple GATA factors, zinc finger DNA binding proteins that reco