ライフサイエンスコーパス: GC-rich

1 Surprisingly, variants with GC-rich 4-nt palindromes were sustained throughout the s

2 eIF4A1-dependent mRNAs frequently have long GC-rich 5'UTRs, the details of how 5'UTR structure is re

3 taining these genes were found to consist of GC-rich (54 to 65%) sequences comparing to the average G

4 omprise the tertiary structure, as well as a GC-rich 6 bp stem (stem 1) and an AU-rich 9 bp stem (ste

5 Recently, the genuine leptin gene with a GC-rich ( 70%) repetitive-sequence content was identifie

6 that the WhiB-like proteins exclusive to the GC-rich actinomycete genera play significant roles in pa

7 irths/deaths over their entire length, while GC-rich Alus only in their 3' poly(A) tails and middle A

8 the proximal promoter of the Cdc2L2 gene is GC rich and does not contain TATA and CAAT boxes.

9 The Mycobacterium tuberculosis genome is GC-rich and contains >10,000 sequences that have the pot

10 emonstrated that the 5' regulatory region is GC-rich and contains no TATA or CAAT box, similar to the

11 trast, rapidly evolving 3' UTRs tended to be GC-rich and derived from genes involved in metabolism an

12 iple promoter and silencer elements that are GC-rich and exhibit considerable single-stranded charact

13 genes mutated in opposite directions-toward GC-rich and GC-poor content, respectively.

14 rabidopsis thaliana genome and the much more GC-rich and heterogeneous rice (Oryza sativa) genome and

15 and homogeneous genomes to the more derived GC-rich and highly heterogeneous ones, with several inde

16 espread expression of CRELD2, this region is GC-rich and lacks a TATA box.

17 sposable element-derived genes are generally GC-rich and mainly derive from GC-rich parental sequence

18 microchromosome, which are known to contain GC-rich and repetitive regions, but at the distal tip of

19 rage as high as 96% and unbiased coverage of GC-rich and repetitive regions.

20 genes; and (3) two regions that were either GC-rich and/or contained tracts of G.

21 PCR amplification over GC-rich and/or long repetitive sequences is challenging

22 n -234 and -23 that lacked TATA element, was GC-rich, and harbored several putative cis-regulatory si

23 e lambda-exo-controlled NS-seq peaks are not GC-rich, and only 35.5% overlap with 6.8% of all G4s, su

24 are AT-rich, the middle four base pairs are GC-rich, and the last six base pairs are AT-rich.

25 gle-copy genes, and because they are now all GC-rich, any derived from AT-rich contexts must have exp

26 this discrepancy is inadequate sequencing of GC-rich areas of the exome.

27 ing sequences, CpG islands, splice sites and GC-rich areas.

28 lysis revealed that ICP27-targeted genes are GC-rich (as are HSV genes), contain cytosine-rich sequen

29 T) and two model junctions, which are AT- or GC-rich at the branch points, to show that binding of th

30 quence-related natural product O-MTases from GC-rich bacteria.

31 rily upon codon usage characteristic of this GC-rich bacterium.

32 inent in the mammalian genome owing to their GC-rich base composition and high density of CpG dinucle

33 ter activation by Osx, suggesting that these GC-rich binding sites were responsible for Satb2 activat

34 bination of approaches, we show that several GC-rich binding transcription factors are involved in po

35 This effect, mediated via LSD1, provides GC-rich binding transcription factors better access to D

36 Screening for GC-rich binding transcription factors that could activat

37 ter activity, through the binding of several GC-rich boxes.

38 , lower levels of EEHV3 and EEHV2, and a new GC-rich branch type, EEHV7.

39 ong to multiple lineages of both AT-rich and GC-rich branches within a new subfamily to be named the

40 how RacA can both specifically recognize its GC-rich centromere and also non-specifically bind the DN

41 lation is in part due to MeCP2's affinity to GC-rich chromatin, a result replicated using published d

42 ly expressed transcription factor that binds GC-rich cis elements.

43 lls showed extensive binding of Smad2/3/4 to GC-rich cis-regulatory elements.

44 AT-rich codons are decoded more quickly than GC-rich codons.

45 t specific targeting and sequencing of these GC-rich cold-spot regions can lead to the identification

46 h mammalian switch regions, because of their GC-rich composition, generates stable R-loops, which pro

47 -2gamma) are transcription factors that bind GC-rich consensus sequences and regulate the expression

48 insert into TA-rich regions within a broader GC-rich context.

49 of several distinct components, including a GC-rich core (core open reading frame [ORF]), an AT-rich

50 ] > AT alternate, d[5'-G(3)(AT)(5)C(3)-3'] > GC-rich d[5'-A(3)G(5)C(5)T(3)-3'].

51 In addition, the GC-rich discriminator destabilized the RNA polymerase-pr

52 cription initiation rate from promoters with GC-rich discriminators, in contrast to the uspA-promoter

53 3 orders of magnitude higher affinity than a GC-rich DNA (A-form, d[5'-A(3)G(5)C(5)T(3)-3']).

54 nonreplicating genomic DNA (LexoG0) enriches GC-rich DNA and G4 motifs genome-wide.

55 n by mithramycin with its ability to bind to GC-rich DNA and globally displace Sp1 family transcripti

56 lation of cytosines makes attraction between GC-rich DNA as strong as that between AT-rich DNA.

57 Here we have shown that hedamycin, a GC-rich DNA binding drug, down-regulated survivin expres

58 C8-linked PBD-MPB hybrids that can stabilize GC-rich DNA by up to 13-fold compared to AT-rich DNA.

59 limates, possibly indicating an advantage of GC-rich DNA during cell freezing and desiccation.

60 nts revealed that hedamycin bound to a 21-bp GC-rich DNA element (-115 to -95) in the survivin promot

61 rase constructs, we have identified an 86-bp GC-rich DNA element (-124 to -39) that mediates the abil

62 Sequence analysis of the TR, a GC-rich DNA element, identified several potential Quadru

63 hat both ZBP-89 and ATM are recruited to the GC-rich DNA elements of the p21(waf1) promoter with HDAC

64 nc finger transcription factor that binds to GC-rich DNA elements.

65 to the transcription start site encodes six GC-rich DNA elements.

66 ite similar, but over time, Alu densities in GC-rich DNA increase in comparison with L1 densities.

67 o propose that long-term Alu accumulation in GC-rich DNA is associated with DNA duplication initiated

68 One of the major selective advantages of GC-rich DNA is hypothesized to be facilitating more comp

69 stress activates the Lmf1 promoter through a GC-rich DNA sequence 264 bp upstream of the transcriptio

70 onsensus Egr-1-binding site element and with GC-rich DNA sequences of the human COL1A2 promoter in vi

71 sed by mithramycin, suggesting regulation by GC-rich DNA sequences.

72 reas NIPBL-bound promoters were enriched for GC-rich DNA sequences.

73 cy at promoters is primarily associated with GC-rich DNA sequences.

74 12- and 8-fold higher expression levels from GC-rich DNA targets.

75 aterial) comprising a challenging methylated GC-rich DNA template under a novel 96-well microplate fo

76 el-like factor 15 (KLF15), which can bind to GC-rich DNA within the E2F1 promoter, is required for ma

77 We have previously shown that hedamycin, a GC-rich DNA-binding antitumor agent, downregulates survi

78 DNA base pairs with a strong preference for GC-rich DNA.

79 proximately 4 bp of AT-rich DNA or 1-2 bp of GC-rich DNA.

80 eps on AT-rich and 'short and slow' steps on GC-rich DNA.

81 ated by LEDGF/p75 and (iii) more frequent in GC-rich DNA.

82 ans and 0.329 in African Americans) within a GC-rich domain containing consensus binding sites for Sp

83 density of a transcriptionally active 95-kb GC-rich domain on chromosome III of the yeast Saccharomy

84 Particularly, the GC-rich dsDNAs are unwound with lower amplitudes under s

85 MGA1 proteins to AT-rich duplex DNA, but not GC-rich duplex DNA, significantly inhibited the methylat

86 r an AT-rich duplex to be more stable than a GC-rich duplex of the same length.

87 ch DNA duplexes associate more strongly than GC-rich duplexes, regardless of the sequence homology.

88 on identified endogenous KLF4 binding to the GC-rich/E-box region of this promoter.

89 This GC-rich element consists of six contiguous runs of guani

90 r activity is mediated via KLF4 binding to a GC-rich element located in the hINV promoter distal regu

91 siveness: a Smad binding element (SBE) and a GC-rich element resembling an OAZ binding site.

92 virulence factor, laccase, via binding to a GC-rich element within the 5'-UAS in response to glucose

93 The potential of the GC-rich element within the bcl-2 promoter region to form

94 Mutation of the GC-rich element, an adjacent AP1 factor binding site, or

95 of nuclear proteins with naturally occurring GC-rich elements in a human genomic DNA.

96 emonstrates that increased binding of Sp3 to GC-rich elements in the betaMyHC promoter is a critical

97 eading to enhanced KLF4 interaction with the GC-rich elements in the p21(Cip1) promoter to activate t

98 NA and protein level and KLF4 binding to the GC-rich elements in the p21(Cip1) proximal promoter.

99 Sp3, and Sp4 and all three proteins bound to GC-rich elements in the VEGFR1 promoter.

100 y, we show that the promoter also contains 5 GC-rich elements that contribute to promoter activity an

101 to have evolved along with these downstream GC-rich elements.

102 5/8 have been thought to preferentially bind GC-rich elements.

103 GC-rich ends are not cut by Artemis alone because of a r

104 This GC effect is unimodal: both GC-rich fragments and AT-rich fragments are underreprese

105 at carry gene fragments specifically acquire GC-rich fragments and preferentially insert into the 5'

106 rs, guanine-cytosine (GC) content, number of GC-rich gene-rich isochores, density of polymorphic site

107 the ends of extremely guanine plus cytosine (GC)-rich genes.

108 Further, we found that GC-rich genes and intergenic regions have higher levels

109 eutherian mammals; indeed, the GC content of GC-rich genes appears to have increased in recent times

110 transcription and translation processes, and GC-rich genes implicated in signal transduction and post

111 pens new opportunities for the expression of GC-rich genes in E. coli.

112 ll significant decrease in the GC content of GC-rich genes later in at least three groups of mammals:

113 no general decreasing trend in GC content in GC-rich genes or in other genes among eutherian mammals;

114 at the last common vertebrate ancestor had a GC-rich genome (~65% GC).

115 rion (0.6-microm diameter) encloses a 651-kb GC-rich genome encoding 523 proteins of which 64% are OR

116 as representative structural and functional GC-rich genomic elements.

117 ests that other similar clusters of genes in GC-rich genomic regions are missing from the current gen

118 he extremely long ( approximately 1.5-5 kb), GC-rich (>80%) coding variable-number tandem repeat (VNT

119 he successful PCR-amplification of extremely GC-rich (>83%) DNA targets.

120 The presence of GC-rich hairpin sequences between substrate-binding prot

121 nd the C-clamp domain for recognition of the GC-rich Helper motif (5'-RCCGCC-3').

122 rgence states inhabit guanine- and cytosine (GC)-rich, highly recombining subtelomeric regions; low d

123 Despite the GC-rich, highly repetitive sequences of ELPs, we synthes

124 ition is the main mechanism for distributing GC-rich human-specific tandem repeat expansions througho

125 ining RNA hairpins immediately upstream of a GC-rich hybrid formed complexes of reduced stability, wh

126 eudicot genomes (35-42% of G+C content), but GC-rich in the monocot genomes (59-61% of G+C content).

127 gamma-herpesviruses were enriched in short, GC-rich initiation sequences such as CCCAG and depleted

128 uences, rice MULEs capture guanine-cytosine (GC)-rich intergenic sequences, albeit at a much lower fr

129 of nicK leads to nicking of ICEBs1 between a GC-rich inverted repeat in oriT, and NicK was the only I

130 tional and biochemical analysis identified a GC-rich, inverted 14 bp repeat as the recognition sequen

131 he nonavian reptiles, are expected to lack a GC-rich isochore structure.

132 e number of chromosomes, it is unlikely that GC-rich isochores are vanishing in these mammals.

133 patterns in mammalian species suggested that GC-rich isochores might be vanishing in mammalian genome

134 isochores than amphibians and fish, and the GC-rich isochores of birds and mammals have been suggest

135 It has been suggested that GC-rich isochores originated in the ancestral amniote ge

136 Birds and mammals have more GC-rich isochores than amphibians and fish, and the GC-r

137 idence that the poikilothermic alligator has GC-rich isochores, like homeothermic birds and mammals.

138 at may promote RNAPII-transcription at these GC-rich microsatellites: the DSIF complex and PAF1C.

139 "AT"-rich motif (M1a-d) and 2 copies of an "GC"-rich motif (M2 a,b), which when mutated cause expans

140 l activation requires binding of E2F/DP to a GC-rich motif that facilitates HSF-1 binding to a heat-s

141 ry structures of these transcripts yielded a GC-rich motif, which was shown to bind to GR in vitro.

142 We also show that GC-rich motifs at the 5' ends of footprints are found in

143 the initiation of DNA packaging and for the GC-rich motifs flanking the pac1 T element in terminatio

144 a cells through two evolutionarily conserved GC-rich motifs in conserved Area II, a control region es

145 s for specific binding of Smad3 and Smad4 to GC-rich motifs in the goosecoid promoter, a nodal-regula

146 bolished interaction of Sp1 and Sp3 with the GC-rich motifs located within the minimal promoter regio

147 es demonstrated that Sp1 and Sp3 bind to the GC-rich motifs, a CACCC box and three GC boxes, located

148 and this was primarily dependent on proximal GC-rich motifs.

149 g studies revealed that Smad4 binds to these GC-rich motifs.

150 of 5' decay applies to optimally translated GC-rich mRNAs.

151 The GC-rich nonanucleotide (N(9)) sequence, which forms the

152 e Fragile X cell lines, as well as extremely GC-rich nonrepetitive segments of the GNAQ and GP1BB gen

153 promoter element of the KRAS gene contains a GC-rich nuclease hypersensitive site with three potentia

154 DNA G-quadruplexes formed in the GC-rich nuclease hypersensitivity element of the human P

155 TF binding sites are located in GC-rich, nucleosome-depleted, and DNase I sensitive regi

156 experimentally observed association rates of GC-rich oligomers are higher than rates of AT- rich equi

157 by sequence similarities and the presence of GC-rich or repeat sequences, and some sequences are comp

158 switching propensity is higher when dsDNA is GC-rich or when the 3'-overhang of forked DNA is <15 bas

159 However, the translation of genes from GC-rich organisms is inefficient in E. coli.To overcome

160 uencing approaches suited to the analysis of GC-rich organisms.

161 These studies suggest that a GC-rich OriLyt transcript is an important component of g

162 mbled by isothermal assembly guided by short GC-rich overlap sequences.

163 ver, DAP-DNA overstretching is distinct from GC-rich overstretching in that it happens at a significa

164 This GC-rich palindrome is completely different from the cons

165 of the selected DIS sequence is a 4- or 6-nt GC-rich palindrome, although not all sequences with thes

166 are generally GC-rich and mainly derive from GC-rich parental sequences.

167 old elements are preferentially found in the GC-rich parts of the genome, while young Alus are more o

168 cAMP-response elements (CRE) and a proximal, GC-rich promoter region, which contained atypical CRE.

169 /TR3/ specificity protein 1 complex bound to GC-rich promoter regions of survivin and other Sp-regula

170 equirement for the NR4A1/Sp4 complex to bind GC-rich promoter regions to elevate transcription of the

171 tween ZBTB4 and Sp transcription factors for GC-rich promoter sequences.

172 r communication between the enhancer and the GC-rich promoter.

173 Instead, a GC-rich proximal region containing a potential Sp1 recog

174 By reducing gene expression, GC-rich RBP-occupied sequences act as a rapidly evolving

175 helicase assays demonstrate that BLM unwinds GC-rich rDNA-like substrates that form in the nucleolus

176 ase II transcription activator that binds to GC-rich recognition sites in a number of essential cellu

177 mplex bound to the proximal germinal center (GC)-rich region of the PD-L1 gene promoter.

178 iments demonstrate that the proximal, highly GC-rich region (positions -165 to -139) of the human PDG

179 RNAcompete identifies a GC-rich region as SERBP1-binding motif; subsequent genom

180 EKLF site within a previously characterized GC-rich region in the p21 proximal promoter but also by

181 ugments promoter activity of p21 through the GC-rich region located between nucleotides -84 and -74 w

182 urther point mutation studies found that two GC-rich region mutations disrupted the Satb2 130bp promo

183 Sp1-p300 DNA binding complex on the proximal GC-rich region of the survivin promoter.

184 moter and that targeted deletion of a single GC-rich region spanning -93 to -58 interrupts Sp1- and D

185 taining a half-estrogen response element and GC-rich region that interact with ER and Sp1 proteins.

186 A highly GC-rich region upstream of the P1 promoter plays an impo

187 The human bcl-2 gene contains a GC-rich region upstream of the P1 promoter that has been

188 The human BCL-2 gene contains a 39-bp GC-rich region upstream of the P1 promoter that has been

189 KLF5's promoter lacks a TATA box and has a GC-rich region.

190 A guanine- and cytosine-rich (GC-rich) region directly upstream of the P1 site has bee

191 The rdLRP contains no DNA repeats or GC rich regions and 30% less positively charged amino-ac

192 ve significant enrichment of heritability in GC-rich regions and in higher-frequency SNPs for both sc

193 IRs are AT-rich sequences flanked by more GC-rich regions and located predominantly in intergenic

194 that NRF2 prefers binding to AREs flanked by GC-rich regions and that NRF1 prefers AT-rich flanking r

195 The SEGS are characterized by GC-rich regions and the absence of long open reading fra

196 family of transcription factors that bind to GC-rich regions in gene promoters.

197 lated promoter activity occurred through two GC-rich regions located within 633 bp of the transcripti

198 e with worker-biased expression are found in GC-rich regions of the bee genome and also experience hi

199 ions for the accumulation of Alu elements in GC-rich regions of the human genome.

200 CpG islands are GC-rich regions often located in the 5' end of genes and

201 these sites shows that RNA Pol II pauses at GC-rich regions that are marked by a sequence motif.

202 These genes tended to cluster in GC-rich regions that have poor coverage in genome sequen

203 onal point mutants were used to identify two GC-rich regions that were responsible for VEGF promoter

204 ellifera, represents a mosaic of GC-poor and GC-rich regions with rates of recombination an order of

205 thod not only for amplification of extremely GC-rich regions, but also for routine DNA diagnostics an

206 particular: structural variants, variants in GC-rich regions, which have significantly improved cover

207 ing four hypoxia-response elements and three GC-rich regions.

208 tate replication through telomeres and other GC-rich regions.

209 dem repeat composed of at least three 7.6-kb GC-rich repeat units reside within a syntenic region of

210 ymorphism analysis with a highly polymorphic GC-rich repetitive sequence located in the plasmid pTBN1

211 y with the proline glutamic acid-polymorphic GC-rich repetitive sequences protein family of M. tuberc

212 binding sites (LBS1 and LBS2 [LBS1/2]) and a GC-rich replication element (RE) upstream of LBS1/2.

213 Additional experiments demonstrated that a GC-rich response element located -6 to -16 (upstream of

214 nucleotide variants in a training set from a GC-rich Rhodobacter sphaeroides genome.

215 ng sequence that includes a 12-14-nucleotide GC-rich RNA duplex between the end of the 5' tRNA half a

216 preferred binding site for this protein is a GC-rich RNA hairpin containing a pyrimidine mismatch.

217 rase (RNAP) occurs at sequences coding for a GC-rich RNA hairpin followed by a U-rich tract.

218 ion (OriLyt) also requires the presence of a GC-rich RNA in cis.

219 SELEX analysis identified GC-rich RNA sequences as a common feature of recognition

220 g the AT-rich discriminator of uspA with the GC-rich rrnB-P1 discriminator made the uspA promoter neg

221 ny sequence-specific role, we randomized the GC-rich sequence ((-20)CCGGCTCG(-13)) within the spacer

222 ll except one case shared common polymorphic GC-rich sequence (PGRS) patterns.

223 ific mycobacterial proteins with polymorphic GC-rich sequence (PGRS).

224 e same AT-rich sequence is concatenated to a GC-rich sequence known to undergo a B-to-S transition ra

225 lized a minimal promoter activity to a 21-bp GC-rich sequence located 130 bp upstream of the X protei

226 the transactivation is partly mediated by a GC-rich sequence located in the promoter.

227 GTCT), whereas the Mad MH1 domains bind to a GC-rich sequence resembling Mad binding sites previously

228 Each repeat unit consists of a 7.3 kb GC-rich sequence that binds the insulator protein CTCF a

229 s (LBS1/2) and an adjacent 29- to 32-bp-long GC-rich sequence which we termed the replication element

230 derivative, DB1242, binds specifically to a GC-rich sequence, -GCTCG-.

231 nts showed that PAGE4 preferentially binds a GC-rich sequence.

232 sting of two LANA binding sites (LBSs) and a GC-rich sequence.

233 n of phage, plasmid, and synthetic A-philic, GC rich sequences by the T4 motor.

234 By contrast, GC-rich sequences (60% GC) are found to undergo a revers

235 multiple transcriptional start sites (TSS), GC-rich sequences and a promoter located within -205/+63

236 RGG box of ICP27 are required for binding to GC-rich sequences and that the N-terminal portion of ICP

237 This suggests that such GC-rich sequences are difficult to sequence and therefor

238 GC-rich sequences are observed to be more stable than AT

239 noglobulin and HIV promoters to identify the GC-rich sequences at each end required for Sp-factor tar

240 The presence of GC-rich sequences at the 5' end of genes may influence t

241 The largest cluster involved GC-rich sequences at the 5' ends of introns that co-occu

242 analysis with the wild-type protein bound to GC-rich sequences did not show any discernible folding.

243 FI sites emerged with a general accretion of GC-rich sequences downstream of the eukaryotic transcrip

244 nergy calculations show that single-stranded GC-rich sequences exhibit more favorable solvation by ch

245 ifically downregulating the transcription of GC-rich sequences in Drosophila.

246 KLF10 occupied GC-rich sequences in the promoter region of the EMT-prom

247 BTEB1 bound to GC-rich sequences in the proximal TrbetaA promoter in vi

248 mily an overlapping sequence specificity for GC-rich sequences in the regulatory regions of multiple

249 GC-rich sequences overstretch at similar if not slightly

250 , which alkylates DNA in the minor groove at GC-rich sequences resulting in an unusual bending toward

251 bind G-quartet structures but instead binds GC-rich sequences that are flexible in structure.

252 Tax binds to GC-rich sequences that immediately flank the CREs.

253 ecipitation assays, have identified distinct GC-rich sequences used by KLF14 to regulate this promote

254 GC-rich sequences were destabilizing of reporter mRNAs a

255 Despite the gene's repetitive and GC-rich sequences, 13% of RPGR gene copies showed mutati

256 HTa preferentially binds to GC-rich sequences, exhibits invariant positioning throug

257 ct gene, which appeared to include extremely GC-rich sequences, using current RACE methods.

258 BMH-21 binds GC-rich sequences, which are present at a high frequency

259 Pif1 did not promote synthesis through GC-rich sequences, which impede strand displacement.

260 of the Xenopus laevis TrbetaA gene has seven GC-rich sequences, which led us to hypothesize that BTEB

261 der to enhance DNA polymerase extension over GC-rich sequences.

262 -form, similar to what has been reported for GC-rich sequences.

263 reference of 3 toward AT-rich sequences over GC-rich sequences.

264 , while coding sequence duplicates are rare, GC-rich, short, and tend not to interact.

265 poly-U and UUAG sequences and destabilizing GC-rich signals.

266 tion by binding to the promoter via specific GC-rich sites and recruiting the Sin3-histone deacetylas

267 ein signaling recognizes a distinct class of GC-rich sites in addition to GTCT.

268 s effect was abrogated after mutation of the GC-rich sites.

269 The proximal p21(Cip1) promoter GC-rich Sp1 factor binding elements are also required, a

270 t Mor interacts with the minor groove of the GC-rich spacer in the Mor binding site.

271 lements, we find that the presence of a more GC-rich spacer or a spacer with the complement of the P(

272 re, the presence of the P(minor) spacer, the GC-rich spacer, or the complement spacer results in diff

273 Egr-1 bound to the GC-rich SPUR activation element in the SMalphaA promoter

274 The p2b hairpin also contains GC-rich stem 1 and a unique uridine-rich helix with a pe

275 h the surface area exposed upon unfolding of GC-rich stem 1 than either AU-rich stem 2 or the hairpin

276 A hybrids followed by formation of a strong, GC-rich stem-loop in the RNA exit channel of RNA polymer

277 t bacterial RNA polymerases (RNAPs) encode a GC-rich stem-loop structure followed by a polyuridine [p

278 ingle-stranded terminal loop and a conserved GC-rich stem.

279 nal and translational regulatory elements in GC-rich Streptomyces genomes is essential to elucidating

280 poson revealed an insertional preference for GC-rich streptomycete DNA compared to E.coli vector DNA.

281 presentation of SP1/SP3-binding sites and/or GC-rich stretches.

282 ogether, the results provide a model for how GC-rich structural and functional eukaryotic markers eme

283 d structure space, we discovered a family of GC-rich structural cis-regulatory RNA elements, termed s

284 other RGG box proteins; it prefers flexible, GC-rich substrates that do not form stable secondary str

285 promoter and initiates transcription across GC-rich tandem repeats.

286 PCR methods for these extremely GC-rich target regions were optimized to give reproducib

287 alance of amplification efficiencies between GC-rich target sequences of different length, we were ab

288 Sp family members bind GC-rich target sequences through their zinc finger domai

289 Early on in the siRNA design, GC-rich target sites were avoided because of their poten

290 However, PCR-amplification of GC-rich templates is often hampered by the formation of

291 mes, pauses are shorter and less frequent on GC-rich templates.

292 Reduced coverage was obtained in the highly GC-rich terminal repeat regions.

293 a long unique coding region (LUR) flanked by GC-rich terminal repeat sequences.

294 Rs in 5'-UTRs of housekeeping genes are more GC rich than those of tissue-specific genes and CGG, the

295 man genome occur more frequently in Alu- and GC-rich than in AT-rich chromosomal regions.

296 these FL-like cells (FLLCs) in nonmalignant GC-rich tissues and the functional consequences of BCL2

297 ciated with a low protein yield; AU-rich and GC-rich transcripts tend to follow distinct decay pathwa

298 The resulting Pack-MULEs form independent, GC-rich transcripts with a negative GC gradient.

299 ipped-strand nucleation of duplex DNA within GC-rich trinucleotide repeats may result in the changes

300 TATA nor a CAAT box, but is, instead, highly GC-rich with multiple transcription initiation sites.