ライフサイエンスコーパス: GC

1 GC also showed a trend towards higher values in dystonia

2 GC area was smaller and plasmablasts/plasma cell numbers

3 GC cells treated with midostaurin or bosutinib significa

4 GC disengagement results in a shift of FFR values from a

5 GC dopamine immunoreactivity was increased in BPA- and B

6 GC exposure induced changes in DNAm at 27,812 CpG dinucl

7 GC x GC/TOFMS allowed five and six co-elutions to be res

8 GC x GC/TOFMS analyses resulted in 145 identified compou

9 GC's activity shows robust modulations before animals' c

10 GC-based mapping tools were optimized for low spatial re

11 GC-MS and FTICR-MS revealed no significant bitumen alter

12 GC-MS data showed a clustering closely matching the one

13 GCs are also the origin of malignancy, namely follicular

14 GCs closer to the white matter (inner-zone GCs) had high

15 ation from conventional one-dimensional (1D) GC to GCxGC, ensuring the integrity of data as conversio

16 nforced with 1D carbon nanotubes (CNTs) (3DP GC) with both high flexural strength and hierarchical po

17 The 3DP GC electrode integrated with a NiFeP nanosheets array ex

18 H, 397 had 881 CT infections and 331 had 861 GC infections, with an incidence of 2.95 and 2.88 per 10

19 RNAcompete identifies a GC-rich region as SERBP1-binding motif; subsequent genom

20 lasting DMSs was also responsive to an acute GC challenge in peripheral blood.

21 umber variation of the ADAR gene in advanced GC and clarify its correlation with survival and histopa

22 bet in B cells in promoting TLR7-driven AFC, GC, and SLE development whereas T1IFN signaling moderate

23 nce, extra-adrenal (local) production allows GCs to act as paracrine signals, specifically targeting

24 Therefore, although GC-1 treatment induces a mild protection against biliary

25 lation between tear MUC5AC concentration and GC area suggests tear MUC5AC mucin can be used as a dise

26 Recent CT and GC incidence and testing increased among PLWH; however,

27 rstanding of the functional output of EF and GC responses and the molecular switches promoting them.

28 with RNAPI distribution: folding energy and GC content in the transcription bubble.

29 identified using solid phase extraction and GC/MS.

30 tforms (GC x GC/TOFMS, GC-O-OSME, GC-FID and GC/MS).

31 (1)H NMR, FTIR, and GC/MS characterization of the fluids indicated that they

32 that contemporaneously developing memory and GC B cells differ in their affinity for antigen througho

33 om 16S rRNA sequencing, Nanostring miRNA and GC-MS targeted analysis, respectively.

34 Metabolite profiling by LC-MS and GC-MS quantified 124 seed metabolites out of which 84 we

35 complex with the lymphoid-enriched OCT2 and GC-specific MEF2B transcription factors and that this co

36 o impede BCR-mediated antigen processing and GC development.

37 residues in banana pulp, using QuEChERS and GC-SQ/MS.

38 medication with OCT measurements of RNFL and GC-IPL.

39 In all ATD, GC number and area were significantly correlated, but di

40 , in part because RIP preferentially attacks GC-poor long duplicates that interact in three dimension

41 at EZH2 mutations initiate FL by attenuating GC B cell requirement for T cell help and driving slow e

42 Within lymph nodes, we observed augmented GC B cell responses and the promotion of T(h)1 gene expr

43 The difference between average GC-IPL thickness and minimum GC-IPL thickness was 2.3 mu

44 The mean average GC-IPL thickness was 85.9 mum (+/- 5.3; 5th and 95th per

45 The average GC-IPL thickness was weakly positively correlated with S

46 ng MT plus ends to actin filaments in axonal GCs, preventing MT depolymerization in F-actin-rich area

47 vel tastant with induction of LTD at the BLA-GC input in vivo was sufficient to change the hedonic va

48 Twenty-seven odorants were detected by GC-O.

49 This effect appears to be driven by GC suppression of 3beta-HSD1 substrate.

50 analysis of pyrethroids in diluted honey by GC-MS.

51 The recorded delta(15)N value by GC-C-IRMS was within the error of that of the underivati

52 cells are found in 10-26% of gastric cancer (GC) and esophagogastric junction cancer (EGJC).

53 in the pathogenesis of human gastric cancer (GC) are unclear.

54 ay is critically involved in gastric cancer (GC) progression.

55 ential sweep voltammetry on a glassy carbon (GC) electrode was developed to distinguish and quantify

56 oltammetric sensor based on a glassy carbon (GC) electrode with analysis following a short one-step e

57 Cardiologists were more likely than cardiac GCs to recommend clinical testing for family members eve

58 Granger causality (GC) analysis, an econometric tool for quantifying causal

59 via two-photon uncaging of glutamate causes GC spines to release GABA both synchronously and asynchr

60 Among rs1333049 risk-allele carriers (CC+GC), the incidence of MI was reduced in the surgery grou

61 hoblast relative to trophoblast giant cells (GCs) within the junctional zone, markedly reduced placen

62 ablation of >50% of mature DG granule cells (GCs) or by prolonged brain-specific VEGF overexpression

63 in mice that express Cre in germinal center (GC) B cells (AID-Cre).

64 mechanistically unclear how germinal center (GC) B cells differentiate into MBCs.

65 rentiation of high-affinity germinal center (GC) B cells into memory B cells versus plasma cells is a

66 e from highly proliferative germinal center (GC) B cells with proliferation strictly dependent on int

67 utoantibodies, frequency of germinal center (GC) B cells, and antigen-specific plasma cells induced d

68 helper T (T(fh)) cells with germinal center (GC) B cells.

69 c coactivator essential for germinal center (GC) formation, forms a ternary complex with the lymphoid

70 e development of T(FH)s and germinal center (GC) response were crucially dependent on TSLP in both th

71 Germinal center (GC) responses require B cells to respond to a dynamic se

72 d Ab-forming cell (AFC) and germinal center (GC) responses, and SLE development has never been direct

73 BACH2 at the expense of the germinal center (GC) TF BCL6, leading to pre-memory transcriptional repro

74 ns in IgE production in the germinal center (GC) that work together to facilitate the production of A

75 mplex bound to the proximal germinal center (GC)-rich region of the PD-L1 gene promoter.

76 Germinal centers (GCs) are confined anatomic regions where rapidly prolife

77 nfrequent within secondary germinal centers (GCs), which instead consist predominantly of B cells wit

78 (Tfh) cell development in germinal centers (GCs).

79 and cellular selection in germinal centres (GCs)(2,3).

80 ive two-dimensional (2D) gas chromatography (GC x GC) system coupled with low- and high-resolution ma

81 ted EO was identified by gas chromatography (GC) and nuclear magnetic resonance (NMR).

82 etic resonance (NMR) and gas chromatography (GC) demonstrate that the hybrid electrode system is able

83 Thus, Tfh induced in classic GC reactions are dispensable for T1D, but the autoimmune

84 Gingival clefts (GCs) develop frequently during orthodontic space closure

85 ology analysis of three independent clinical GC cohorts revealed significant involvement of DOCK6-cor

86 Globular clusters (GCs) are dense, gravitationally bound systems of thousan

87 In contrast to this complexity, GC B cells are canonically divided into two principal po

88 a disease-relevant biomarker for conjunctiva GC health.

89 Compared to control conjunctiva, GC number and area were significantly lower in SS, non-S

90 to the StretchEP, and Global Connectedness (GC) estimated the spatial extent of the StretchEP networ

91 how response properties of gustatory cortex (GC) neurons change as a function of their laminar positi

92 l population model that both orders critical GC functions and reveals essential molecular programs of

93 correlates with increased guanine-cytosine (GC) content, suggesting a key role for GC-biased gene co

94 phy coupled with flame ionisation detection (GC-FID).

95 The newly developed GC-C-IRMS method was applied to modern plant protein and

96 In associative learning, DG GCs, more so than LEC neurons, changed their responses t

97 ng in extensive, highly selective loss of DG GCs (thereby also reinforcing the notion of selective DG

98 ependent crosstalk with B cells and dictated GC output by retaining B cells in the follicle and steer

99 Two dimensional GC (GC x GC) significantly enhances discrimination of th

100 ontent increases and decreases as downstream GC content increases.

101 nsic roles of STAT1 and T-bet in TLR7-driven GC, Tfh and plasma cell differentiation.

102 Optimal low EI GC-QTOF parameters (EI energy: 15 eV, acquisition rate:

103 l sensor based on a glassy carbon electrode (GC) modified with graphene quantum dots (GQDs) and Nafio

104 ession by baseline diagnosis and to estimate GC risk by intestinal metaplasia (IM) subtype and anatom

105 s, and also prompt future studies to examine GCs' effects on clinical outcomes likely dependent on fu

106 ipal cells in the rat (both sexes) OB excite GCs by evoking potent nondepressing EPSPs (termed large-

107 ization detector (PID), thus creating a fast GC-PID system.

108 t gas chromatography-mass spectrometry (fast-GC-MS).

109 KO mice fed GC-1 diet for 2 and 4 weeks had decreased serum alkaline

110 e plasma-cell-biased CD80(+) subset, and few GCs arose following heterologous boosters, demonstrating

111 We refer to these fish GCs as spot detectors (SDs) by analogy with the frog SD.

112 malignancy, namely follicular lymphoma (FL), GC B cell-diffuse large B cell lymphoma (GCB-DLBCL), and

113 e dysplasia and 0.14 (95% CI, 0.06-0.22) for GC.

114 IM showed an OR of 2.1 (95% CI, 0.7-6.6) for GC.

115 , it is convenient for Nubeam to account for GC bias and nucleotide quality.

116 reas NIPBL-bound promoters were enriched for GC-rich DNA sequences.

117 YC is transiently induced in cells fated for GC expansion and plasma cell (PC) formation, so-called p

118 ing ethanol as an internal standard (IS) for GC-MS quantification of volatile compounds in alcoholic

119 sine (GC) content, suggesting a key role for GC-biased gene conversion and/or repair after the breaka

120 desorption after SMS to collect samples for GC-mass spectrometry (GC-MS) measurements.

121 gesting that UBE2T is a promising target for GC therapy.

122 Further, there was a tendency for GC development in the presence of buccal bone dehiscence

123 ed using glass-hybrid material (Equia Forte, GC).

124 e been raised regarding adverse effects from GC, thereby necessitating a better understanding of how

125 Two dimensional GC (GC x GC) significantly enhances discrimination of therma

126 notorious adverse effects, glucocorticoids (GC, potent anti-inflammatory drugs) are used extensively

127 Glucocorticoids (GCs) are a central component of therapy for patients wit

128 bility to anti-inflammatory glucocorticoids (GCs).

129 rt via enhanced exposure to glucocorticoids (GCs), which are known to impact neurogenesis.

130 and keloids, the efficacy of glucorticoids (GC) for vocal fold injury is highly variable.

131 Although chlamydia (CT) and gonorrhea (GC) infections are increasing in the United States, ther

132 m ground controls housed in flight hardware (GC), while thymus weights were 35% greater in FLT than G

133 equence-specific binding to a region of high GC content (76%) derived from a CpG island embedded in s

134 entify a subset of RNA-DNA hybrids with high GC skew which are partially resistant to RNase H.

135 Using this metric, we demonstrate how GC skew patterns are conserved within certain bacterial

136 necessitating a better understanding of how GCs modulate the immune response.

137 ndesirable pink color, thus, NMR, UPLC-HRMS, GC-MS analyses combined with chemometrics approach were

138 onin (5-HT) concentrations, and lowered 5-HT GC immunoreactivity.

139 behavior whereby Tfh cells migrate in human GC and highlight the heterogeneity of GC for Tfh cell mo

140 e-cell (sc) transcriptomic analysis on human GC B cells and identified multiple functionally linked s

141 was dependent on signaling via PI3K/AKT, in GC stem-like cells distinguished by CD44 expression.

142 xisting methods do not control for biases in GC content or dinucleotide composition.

143 s show higher baseline firing rates (FRs) in GC with deep-layer inhibitory neurons displaying highest

144 Bcl-6 directly repressed Hhex in GC B cells.

145 e copy number in liquid biopsy was higher in GC and EGJC patients compared to healthy people (p = 0.0

146 (EMT), and lung and lymphatic metastasis in GC cells.

147 on, especially for the metastatic process in GC.

148 omotion of T(h)1 gene expression profiles in GC T(fh) cells.

149 l is negatively associated with prognosis in GC patients, suggesting that UBE2T is a promising target

150 ntrolled a unique transcriptional program in GC B cells that promoted optimal GC polarization and cho

151 RACK1 deficiency plays a significant role in GC progression, but not APC, AXIN, and GSK3beta.

152 eta)-like 1 X-linked receptor 1 (TBL1XR1) in GC cells, including stem-like cells.

153 degradation events regulate BCR functions in GCs is unclear.

154 Interestingly, UHMK1-induced GC progression was mediated primarily via enhancing de n

155 f naive B cells with a low-affinity BCR into GCs to initiate the process of affinity maturation.

156 We also demonstrated that this pathway is GC-responsive since treating mice with dexamethasone res

157 acular ganglion cell- inner plexiform layer (GC-IPL) thickness in healthy 6.5 year- old Swedish child

158 ea, and ganglion cell-inner plexiform layer (GC-IPL) thickness measurements were evaluated using univ

159 icacy and reduced toxicities, macromolecular GC prodrugs have been developed with promising outcomes

160 r trend was noted in our analysis of macular GC-IPL thickness.

161 is uniquely required by normal and malignant GC B cells.

162 We report a massive GC in the Andromeda Galaxy (M31), RBC EXT8, that is extr

163 between average GC-IPL thickness and minimum GC-IPL thickness was 2.3 mum (+/- 1.9; 5th and 95th perc

164 The mean minimum GC-IPL thickness was 83.6 mum (+/- 4.9; 5th and 95th per

165 Although most GCs are transient(3), those in intestinal Peyer's patche

166 with poor clinical outcome in HER2-negative GC.

167 This study provides normative GC-IPL thickness values for healthy 6.5 year- old Swedis

168 tigen uptake and processing by naive but not GC B cells depend on Cbl and Cbl-b (Cbls), which consequ

169 Presence or absence of GC after 3 and 6 months ("time-point") was recorded and

170 s a single metric representing the degree of GC skew for a genome.

171 aturation of the response and development of GC B cells.

172 To explore the dynamics of GC B cell development beyond the known dark zone and lig

173 or T cell help and driving slow expansion of GC centrocytes that become enmeshed with and dependent o

174 human GC and highlight the heterogeneity of GC for Tfh cell motility.

175 Incidence of GC is affected by various factors, including genetic and

176 belonging to deep and superficial layers of GC.

177 ns located in deep and superficial layers of GC.

178 utility of DOCK6 as an independent marker of GC.

179 nostic indicator in T-ALL, the mechanisms of GC resistance remain poorly understood.

180 therapeutic strategies for the metastasis of GC.

181 compare and perform molecular networking of GC-MS data within the Global Natural Product Social (GNP

182 re lymph node metastasis and poor outcome of GC patients.

183 ivity strongly shapes the spiking pattern of GC pyramidal neurons, eliciting phase-locked spiking acr

184 Incomplete IM is a strong predictor of GC risk.

185 of 44) with vancomycin, whereas the rate of GC at EOS was significantly higher in participants recei

186 Conversely, in central regions of GC light zones, Tfh cells are much more static, forming

187 and therapeutically targetable regulator of GC responses.

188 The reproducibility of GC/GQDs-NF for both species had an RSD of less than 10%.

189 how Tfh cells contribute to the selection of GC B cells, with a particular emphasis on how Tfh cell s

190 Chemogenetic silencing of GC impaired task performance.

191 of targeting Tfh cells for the treatment of GC-derived lymphomas is discussed.

192 may represent a target for the treatment of GC.

193 ell-specific and pathway-specific effects of GCs, and also prompt future studies to examine GCs' effe

194 the most conservative threshold, PLS1-DA on GC data allowed very good predictions for Chemlali varie

195 program in GC B cells that promoted optimal GC polarization and cholesterol biosynthesis.

196 ever, only half of MSM were tested for CT or GC during 2016-2017 and less than a third of tests were

197 tritis and isolates from subjects with IM or GC; 12 of these showed a significant correlation with th

198 here responses of orientation selective (OS) GCs were recorded.

199 graphic platforms (GC x GC/TOFMS, GC-O-OSME, GC-FID and GC/MS).

200 In the outer GC light zones, Tfh cells migrate actively and with a hi

201 Overall, GCs were frequent after 3 (DM: 53.9%; EM: 69.2%) and 6 m

202 81a, and miR-93 were determined in 24 paired GC tissues and corresponding non-cancerous tissues by qu

203 gical approach, including NMR, MS, HPLC-PDA, GC-MS and spectrophotometric analyses, was proposed to a

204 Finally, the use of a specialty-phase GC column (Restek Rtx-200) significantly improved peak s

205 n of phage, plasmid, and synthetic A-philic, GC rich sequences by the T4 motor.

206 ective GR modulator (sGRm) normalized plasma GC levels and all behavioral and biochemical parameters

207 through different chromatographic platforms (GC x GC/TOFMS, GC-O-OSME, GC-FID and GC/MS).

208 recurrent BCR clonotypes to seed chronic PP GC responses.

209 PP GCs from different mice expand public BCR clonotypes (cl

210 te physiological BCR repertoires in mouse PP GCs.

211 responses of developing, but not preexisting GCs in vivo in both awake and anesthetized mice.

212 nsist predominantly of B cells without prior GC experience or detectable clonal expansion.

213 Therefore, mu-Raman, mu-FTIR, and pyr-GC/MS were further tested for their capability to distin

214 pectroscopy) and complimented with pyrolysis-GC-MS, while the colour changes were evaluated using col

215 C2s were adoptively transferred into Rag(-/-)GC(-/-) mice, which were then challenged with IL-33 and

216 ) with FFR values in the 0.81 to 0.85 range, GC disengagement was associated with a shift from above

217 plasmid gene content, bacterial host range, GC content, and existing classifications based on replic

218 , while coding sequence duplicates are rare, GC-rich, short, and tend not to interact.

219 f positively selected GC B cells and reduced GC B cell expansion and PC formation.

220 from the focal CpG and modulated by regional GC content.

221 However, how apoptotic caspases regulate GC B cell fate has not been fully characterized.

222 eared more physically active than respective GC while soleus muscle showed expected atrophy.

223 of frog SDs and analogous mammalian retinal GCs-local edge detectors (LEDs).

224 es as strong candidates for promoting robust GC-derived immune responses.

225 With the same SBSE-GC x GC-MS methodology, a quantitative targeted analysis

226 demonstrate the operation of the on-line SDE-GC/MS system, we performed analyses of selected real sam

227 ired cell cycle entry of positively selected GC B cells and reduced GC B cell expansion and PC format

228 PC) formation, so-called positively selected GC B cells.

229 Mean bacterial genome size, GC content, total number of tRNA genes, total number of

230 vaccine, elicited potent SARS-CoV-2-specific GC B and T follicular helper (Tfh) cell responses as wel

231 molecular rotational resonance spectrometer (GC-MRR).

232 upled with time-of-flight mass spectrometry (GC x GC-TOFMS).

233 -combustion-isotope ratio mass spectrometry (GC-C-IRMS) based method was developed and applied for an

234 Gas chromatography-mass spectrometry (GC-MS) analyses of sera from WT and Pax5+/- mice demonst

235 formed gas chromatography-mass spectrometry (GC-MS) and gas chromatography-isotope ratio mass spectro

236 ion of gas chromatography-mass spectrometry (GC-MS) data.

237 to collect samples for GC-mass spectrometry (GC-MS) measurements.

238 Gas chromatography-mass spectrometry (GC-MS) was used for the accurate, feasible and precise d

239 using gas chromatography-mass spectrometry (GC-MS).

240 ), and gas chromatography-mass spectrometry (GC-MS).

241 nes by gas chromatography mass spectrometry (GC-MS).

242 gas chromatography-tandem mass spectrometry (GC-MS/MS) with sum of concentrations (gas + particle pha

243 romatography-olfactometry-mass spectrometry (GC-O-MS) to find the compounds responsible for off-odors

244 matography time-of-flight mass spectrometry (GC-TOF MS) and liquid chromatography Orbitrap mass spect

245 romatography-isotope ratio mass spectromety (GC-IRMS) analyses on a set of samples including drill du

246 atography coupled to mass spectrophotometry (GC-MS) was used to study the volatile fraction of feijoa

247 tile profiles identified by means of HS-SPME-GC-MS analysis, significantly differed in terms of terpe

248 An HS-SPME-GC-MS method was optimized for their quantitation in num

249 as chromatography-mass spectrometry (HS-SPME-GC-MS) method for the quantification of 3-monochloroprop

250 as Chromatography-Mass Spectrometry (HS-SPME-GC-MS).

251 compound profile was examined using HS-SPME-GC-MS.

252 d by a quantitative analysis through HS-SPME-GC-MS.

253 ured using the sensory technique and HS-SPME-GC/MS analyses.

254 , chocolate aroma was profiled using HS/SPME-GC-MS for three different time and temperature combinati

255 can be distinguished other EPSPs that target GCs.

256 ography time-of-flight mass spectrometry (TD-GC-ToF-MS) and detected a total of 115 VOCs.

257 thymus weights were 35% greater in FLT than GC.

258 stain firing with larger current inputs than GCs closer to the Purkinje cell layer (outer-zone GCs).

259 Our data indicate that GC light zones are composed of two distinct areas in ter

260 The GC was retrofitted with a reverse fill/flush (RFF) flow

261 The GC-FP platform yielded a quantitative, linear response f

262 The GC-IPL thickness variations within eyes and within eye p

263 ee of interference of polyester resin in the GC-MS and Carbon-IRMS signals of different lipid fractio

264 SIGN-R1(+) macrophages in regulation of the GC reaction and highlights the functional specification

265 (Tfh) cell interaction and initiation of the GC reaction.

266 at may promote RNAPII-transcription at these GC-rich microsatellites: the DSIF complex and PAF1C.

267 (Arabica and Robusta) were analyzed through GC-MS and two clean-up methods were compared.

268 The evaluation of these wines through GC-O-OSME together with GC-FID, MS resulted in the desig

269 populations of normal developing thymocytes, GCs paradoxically induced their own resistance by promot

270 ong with matched controls, were subjected to GC x GC-TOFMS analysis.

271 leukemia (T-ALL), and although resistance to GCs is a strong negative prognostic indicator in T-ALL,

272 ne-third of primary T-ALLs were resistant to GCs when cells were cultured in the presence of IL-7, a

273 nt chromatographic platforms (GC x GC/TOFMS, GC-O-OSME, GC-FID and GC/MS).

274 CX, n = 13) or left (LGCX, n = 9) unilateral GC lesions and sham-operated controls (SHAM, n = 16) wer

275 Electronic waste dust was analyzed using GC and quadrupole time-of-flight MS with APCI and SQDIA

276 avonols and flavan-3-ols) was analyzed using GC-FID, LC-DAD and LC-MS methods, whereas the volatile c

277 ges by means of a metabolomic approach using GC-MS.

278 lity assessment and calibration curves using GC-qMS and GCxGC-qMS/FID document the transfer and adapt

279 PLS1-DA models using GC data gave better results than those using MIR data.

280 esults compared well to those obtained using GC-MS (average percent difference of -9% across 9 PAHs i

281 quencing, capable of handling widely varying GC-bias, and demonstrating direct detection of epigeneti

282 sought to determine the mechanism(s) whereby GCs influence the fibrotic response and mechanisms under

283 -catenin destruction complex associated with GC progression from clinical samples, and found that sca

284 ive HSD3B1(1245) genotype is associated with GC resistance.

285 Differentially methylated sites (DMSs) with GC exposure clustered into 4 trajectories over HPC diffe

286 ersus control eyes, and correlated only with GC area.

287 ociated with FEV(1)PP and is suppressed with GC treatment.

288 these wines through GC-O-OSME together with GC-FID, MS resulted in the designation of 19 degrees Bri

289 , FFR was prospectively measured twice (with GC engaged [FFR(eng)] and disengaged [FFR(dis)]) in 202

290 ssive alleles and FEV(1)PP in patients with (GC) and without (noGC) daily oral glucocorticoid treatme

291 Two dimensional GC (GC x GC) significantly enhances discrimination of thermal des

292 wo-dimensional (2D) gas chromatography (GC x GC) system coupled with low- and high-resolution mass sp

293 With the same SBSE-GC x GC-MS methodology, a quantitative targeted analysis was

294 ith matched controls, were subjected to GC x GC-TOFMS analysis.

295 with time-of-flight mass spectrometry (GC x GC-TOFMS).

296 GC x GC/TOFMS allowed five and six co-elutions to be resolved

297 GC x GC/TOFMS analyses resulted in 145 identified compounds a

298 gh different chromatographic platforms (GC x GC/TOFMS, GC-O-OSME, GC-FID and GC/MS).

299 GCs closer to the white matter (inner-zone GCs) had higher firing thresholds and could sustain firi

300 loser to the Purkinje cell layer (outer-zone GCs).