ライフサイエンスコーパス: GDP-bound form

1 ogue of cofactor D, specifically when in the GDP-bound form.

2 sent the crystal structure of RasS17N in the GDP-bound form.

3 an active, GTP-bound form, and an inactive, GDP-bound form.

4 ebGAP, converting Rheb from a GTP-bound to a GDP-bound form.

5 ally activated GTP-bound Ras to the inactive GDP-bound form.

6 ally disordered state similar to that of the GDP-bound form.

7 ctive GTP-bound conformation and an inactive GDP-bound form.

8 direct allosteric effect that stabilizes the GDP-bound form.

9 ith an active GTP-bound form and an inactive GDP-bound form.

10 , and N-Ras, and can identify GEFs by use of GDP-bound forms.

11 hes cycling between active GTP- and inactive GDP-bound forms.

12 a(i1), G alpha(i2), and G alpha(i3) in their GDP-bound forms.

13 e conformational differences between GTP and GDP-bound forms.

14 between their active GTP-bound and inactive GDP-bound forms.

15 tructures of VcNFeoB in both the apo and the GDP-bound forms.

16 t ARF6-T27N, which is predicted to be in the GDP-bound form, also stimulated apical endocytosis, thou

17 e (GTPase) Ran in its guanosine diphosphate (GDP)-bound form and to karyopherin beta.

18 s are GTPases that cycle between an inactive GDP-bound form and an active GTP-bound conformation.

19 movement by oscillating between an inactive GDP-bound form and an active GTP-bound form.

20 kDa proteins which cycle between an inactive GDP-bound form and an active GTP-bound state.

21 Arfs cycle between an inactive, cytoplasmic, GDP-bound form and an active, membrane-associated, GTP-b

22 for the GTP-bound form of Ypt1p than for the GDP-bound form, and is specific to a subgroup of exocyti

23 w is that Rabs are soluble in their inactive GDP-bound form, and only upon activation and conversion

24 es in the low-frequency modes of the GTP and GDP-bound forms appear to play a role in ligand binding.

25 Rabs in their GDP-bound form are kept soluble in the cytoplasm by the

26 of the Galpha subdomain, whereas the apo and GDP-bound forms are considerably more open and dynamic.

27 AGS3 stabilizes Galpha(i3) in its GDP-bound form, as it inhibits the increase in tryptopha

28 On the other hand, the inhibition of the GDP-bound form decreased Vmax, but did not alter the Ca2

29 tely 20-kDa GTPases that are inactive in the GDP-bound form, depends on guanine nucleotide-exchange p

30 eam activator Concertina, in its GTP but not GDP bound form, dissociates DRhoGEF2 from microtubule ti

31 ine nucleotide binding state of Rad with the GDP-bound form exhibiting 5-fold better binding to CaM t

32 , a protein that extracts Rab GTPases in the GDP-bound form from membranes, potently inhibits fusion.

33 Comparison with the structure of EF-Tu in GDP-bound form from Thermus aquaticus shows that althoug

34 We propose that conversion of ARF6 into the GDP-bound form in the apical domain of hair cells is ess

35 s is determined by the ratio of GTP-bound to GDP-bound forms in the cell.

36 th regions also stabilize G alpha(i1) in its GDP-bound form, inhibiting the increase in intrinsic try

37 Conversion from the GTP- to the GDP-bound form is achieved by a weak endogenous GTPase a

38 sults suggest that conversion of ARF6 to its GDP-bound form is necessary for final stabilization of t

39 of a Rho family member, whereas the inactive GDP-bound form is sequestered primarily in the cytoplasm

40 ir ability to cycle between the GTP- and the GDP-bound forms is thought to be crucial for their funct

41 ncreased rate of cycling between the GTP and GDP-bound forms leading to cell transformation.

42 only in the inactive guanosine diphosphate (GDP)-bound form of KRAS(G12C), sparing the wild-type pro

43 However, unlike the wild-type protein, the GDP-bound form of alpha(T)E203A was constitutively activ

44 re particularly important in stabilizing the GDP-bound form of ARD1.

45 iates preferentially with Cdc24, whereas the GDP-bound form of Bud1 associates with Bem1.

46 we found that AGS3 binds exclusively to the GDP-bound form of Galpha(i3).

47 o, and this interaction is stronger with the GDP-bound form of Galphao.

48 8 bound exclusively to the GTP-, but not the GDP-bound form of Ha-Ras.

49 tant selective drugs targeting the inactive, GDP-bound form of KRAS(G12C) have been approved for use

50 somewhat different mechanism, given that the GDP-bound form of many G protein alpha subunits does not

51 hat REP forms a stable complex only with the GDP-bound form of Rab but not the GTP-bound form, sugges

52 o show that, although FIPs interact with the GDP-bound form of Rab11 in vitro, the binding affinity (

53 GTP-bound RAB7, but not a dominant-negative GDP-bound form of RAB7, promoting rapid transfer and lys

54 show that RPGR primarily associates with the GDP-bound form of RAB8A and stimulates GDP/GTP nucleotid

55 ug-like molecules that bind to a site on the GDP-bound form of Ral.

56 s have shown that NTF2 binds directly to the GDP-bound form of Ran/TC4 and to proteins of the nuclear

57 port pathway and that the association of the GDP-bound form of Ran/TC4 with NTF2 helps define vectori

58 sociation inhibitor (GDI) complexes with the GDP-bound form of Rho and inhibits its activation.

59 fect of product inhibition by binding to the GDP-bound form of RhoA with a Kd of 6 microM in comparis

60 identify an unforeseen principle by which a GDP-bound form of the conserved small G protein Rho GTPa

61 The GDP-bound form of the GTGs exhibits greater ABA binding

62 e-depleted form of Cdc42Hs and weakly to the GDP-bound form of the GTP-binding protein but does not b

63 o the structures for the signaling-inactive, GDP-bound form of the protein, contrary to what has been

64 or the selective interaction of REP with the GDP-bound form of the Rab substrate.

65 A resolution X-ray crystal structure of the GDP-bound form of the RanQ69L mutant that is used extens

66 n inhibitors (GDIs), form a complex with the GDP-bound form of the Rho family of monomeric G proteins

67 AlF4--induced complex formation between the GDP-bound form of the Rho subfamily G-protein Cdc42Hs an

68 between eIF-5A and TGase is specific for the GDP-bound form of the TGase and is not detected when the

69 switch regions of the GTP-bound but not the GDP-bound form of this mutant adopt an "open conformatio

70 cysteine as well as the preponderance of the GDP-bound form of this mutant.

71 Moreover, unlike the GDP-bound forms of alphaT*, alphaT*(R238A) and alphaT*(R

72 rast, mu4 binds equally well to the GTP- and GDP-bound forms of ARF1 and is less dependent on switch

73 ecially surprising was that the GMP-PCP- and GDP-bound forms of Cdc42 did not show detectable differe

74 in contrast to the prevailing view that the GDP-bound forms of G proteins are inactive, our study re

75 YopT cleaves GTP- and GDP-bound forms of RhoA equally, suggesting that the cle

76 e RopGAP CRIB domain interacts with GTP- and GDP-bound forms of Rop, as well as the transitional stat

77 The distribution between the GTP- and GDP-bound forms of the protein is regulated by evolution

78 ll GTPases may be regulated by both GTP- and GDP-bound forms of the protein.

79 The structures of the GDP-bound forms of the wild-type and mutant proteins are

80 latively low affinity for the GTPgammaS- and GDP-bound forms of these proteins.

81 fectors can distinguish between the GTP- and GDP-bound forms of this G-protein and ensure that the ne

82 on that is intermediate between the GTP- and GDP-bound forms of wild-type Ras and that is similar to

83 es for both active (GTP-bound) and inactive (GDP-bound) forms of Galpha subunits.

84 ulations of active (GTP-bound) and inactive (GDP-bound) forms of wild-type and mutant K-Ras, with an

85 ild-type Galpha(t) and three of its mutants (GDP-bound form only): F332A, A322S, and Q326A that are k

86 lled by the interconversion between GTP- and GDP-bound forms partly regulated by the binding of the g

87 subunits are thought to lock G alpha in the GDP-bound form, prevent it from activating its effector,

88 bound form promoted by GEFs and its inactive GDP-bound form promoted by GAPs to affect the control of

89 that cycles between a guanosine diphosphate (GDP)-bound form (RanGDP) and a guanosine triphosphate (G

90 h p97 and NTF2 are specific for the GTP- and GDP-bound forms, respectively.

91 ild-type RhoA is predominantly in the [(32)P]GDP-bound form, RhoA(Val-14) is predominantly in the [(3

92 other guanine nucleotide binding proteins in GDP-bound forms show that the Mg2+ co-ordination pattern

93 ycle between GTP- and guanosine diphosphate (GDP)-bound forms, suggesting that regulation of RhoH exp

94 he transition state (TDalphaGDP*AMF) and the GDP-bound form (TDalphaGDP) with RGS-r and PDE, respecti

95 on the mutants that show that even in their GDP-bound forms, the A322S and F332A mutants acquire an

96 s trigger conversion of Ras from an inactive GDP-bound form to an active GTP-bound form.

97 s), which convert them from their "inactive" GDP-bound form to the "active" GTP-bound form.

98 synthesis initiation factor 2 (eIF2) from a GDP-bound form to the active eIF2-GTP complex.

99 We fused the Rho family GTPase Cdc42 in its GDP-bound form to the photosensory domain of phytochrome

100 l structures of N150T VcNFeoB in the apo and GDP-bound forms to reveal H-bonding differences surround

101 Pgamma complexed with Talpha (both GTP- and GDP-bound forms) was not ADP-ribosylated; however, agmat