ライフサイエンスコーパス: GPI anchor

1 s a transmembrane (TM) domain instead of the GPI anchor.

2 of a Kunitz-3 domain, and (3) it contains a GPI anchor.

3 oding for arabinogalactans and proteins with GPI anchors.

4 tein (PfRipr) lack transmembrane domains and GPI anchors.

5 in reduced, but not absent, biosynthesis of GPI anchors.

6 membranes via a class of glycolipids called GPI anchors.

7 osition of its glycosylphosphatidylinositol (GPI) anchor.

8 d a sialylated glycosylphosphatidylinositol (GPI) anchor.

9 f cells through a glycophosphatidylinositol (GPI) anchor.

10 ma membrane via a glycophosphatidylinositol (GPI) anchor.

11 rane through a glycosylphosphatidylinositol (GPI) anchor.

12 at is an essential and invariant part of all GPI-anchors.

13 GDPDs, cleaves glycosylphosphatidylinositol (GPI) anchors.

14 ng LRE variants lacking domains critical for GPI anchor addition also rescued lre female gametophyte

15 Consistently, LRE-cYFP-TM, where GPI anchor addition domains were replaced with a single-

16 we provide evidence that increased levels of GPI anchor addition in malignant breast epithelial cells

17 s the M8CM, but not the domains required for GPI anchor addition.

18 which membrane localization is dependent on GPI anchor addition.

19 ARTC2.2 is a toxin-related, GPI-anchored ADP-ribosyltransferase expressed by murine

20 s for longer than PrP(C) with a conventional GPI anchor and was not converted to PrP(Sc).

21 The results strongly suggest that GPI anchoring and the localization of PrP(C) to rafts ar

22 usually contain a glycophosphatidylinositol (GPI) anchor and large Asn-linked glycans, which can also

23 tivity depends on glycophosphatidylinositol (GPI) anchoring and the abundance of amyloid plaques and

24 Besides glycosylphosphatidylinositol (GPI) anchors and N-glycosylation, O-fucosylation has bee

25 In fungi, many cell wall proteins are GPI-anchored, and disruption of GPI-anchored proteins im

26 o assemble N-glycans, O-glycans, a C-glycan, GPI-anchors, and polysaccharides, along with their precu

27 we show that products of both genes contain GPI-anchors, and unexpectedly, that GPI-anchored MMPs pr

28 dings should have important implications for GPI-anchored antibody-based therapy against HIV-1.

29 ndings should have important implications in GPI-anchored antibody-based therapy against HIV-1.

30 ng proteins involved in the synthesis of the GPI anchor are reported to cause a wide spectrum of inte

31 e-specific ADP ribosyltransferase (ART)-1, a GPI-anchored ART that transfers ADP-ribose from NAD to a

32 ses the clustering of sialic acid-containing GPI anchors at high densities, resulting in altered memb

33 Glycosylphosphatidylinositol (GPI) anchors attach nearly 150 proteins to the cell memb

34 tent with the hypothesis that the sialylated GPI anchor attached to PrP(C) acts as a synapse homing s

35 -anchored protein, and were dependent on the GPI anchor attached to PrP(C) containing two acyl chains

36 he role of the glycosylphosphatidylinositol (GPI) anchor attached to PrP(C) in prion formation was ex

37 cleavage site 3 aa upstream of the predicted GPI anchor attachment site of ARTC2.2.

38 The data suggests that the GPI-anchor attachment and localization of LTPGs may be c

39 pha-fucosidase, soluble beta-glucosidase and GPI-anchored beta-glucosidase.

40 ase (GPI-GnT), involved in the first step of GPI anchor biosynthesis in eukaryotes.

41 (PIGA), a gene involved in the first step of GPI anchor biosynthesis; however, alternative mutations

42 quirements and glycosylphosphatidylinositol (GPI) anchor biosynthesis, as well as identification of m

43 s required for glycosylphosphatidylinositol (GPI) anchor biosynthesis.

44 synthesis, and glycosylphosphatidylinositol (GPI)-anchor biosynthesis.

45 se genes associated with deficiencies of the GPI-anchor biosynthesis pathway and also serves to highl

46 -acylation (palmitoylation), prenylation and GPI anchors but until recently little was truly known ab

47 ttachment of a glycosylphosphatidylinositol (GPI) anchor, but whether TFPIbeta protein is actually ex

48 prions in vitro and suggest that the PrP(C) GPI anchor can modulate the propagation of synthetic TSE

49 The GPI anchoring can regulate subcellular localization of t

50 To determine whether GPI anchoring can similarly modulate the assembly of oth

51 nal modifications, such as glycosylation and GPI anchoring, can affect the transmissibility of prions

52 ric VLPs (cVLPs) containing influenza HA and GPI-anchored CCL28 as antigen and mucosal adjuvant, resp

53 We studied the adjuvanticity of GPI-anchored CCL28 co-incorporated with influenza HA-ant

54 Thus, GPI-anchored CCL28 in influenza VLPs act as a strong imm

55 Thus, the results suggest that the GPI-anchored CCL28 induces significantly higher mucosal

56 uPAR is a GPI-anchored cell membrane receptor that shows increased

57 e show that the folate-receptor 1 (FolR1), a GPI-anchored cell surface molecule, specifically marks m

58 lity to adhere to host tissue is mediated by GPI-anchored cell wall proteins (GPI-CWPs); the correspo

59 GDE3 releases soluble CNTFRalpha by GPI-anchor cleavage from the plasma membrane and from ex

60 s) by releasing it from the membrane through GPI-anchor cleavage.

61 on of glycosylphosphatidylinositol-anchored (GPI-anchored) complement inhibitors.

62 embrane and only a truncated version without GPI-anchor complemented the mutant, proving that Brachyp

63 een at 37 degrees C with RUSH VSVG or a RUSH GPI-anchored construct using a biotin pulse to release t

64 g it is bound at cell surfaces to a separate GPI-anchored coreceptor.

65 interactions between PfRH5, PfRipr, and the GPI-anchored CyRPA clearly defines the components of the

66 the carboxyl-terminal GPI anchor, while the GPI anchor deletion mutant exhibits dominant negative ac

67 ) lacking the glycosylphosphatidyl inositol (GPI) anchor, denoted PrP(DeltaGPI).

68 resemble PrPSc, raising the possibility that GPI anchor-dependent modulation of protein aggregation m

69 provide strong evidence that in cell culture GPI anchor-directed membrane association of PrP(C) is re

70 Glycosylphosphatidylinositol (GPI) anchor-directed membrane association appears to be

71 Together, these results showed that GPI anchoring directs the assembly of Sup35NM into non-f

72 These data suggest that female-derived GPI-anchored ENODLs play an essential role in male-femal

73 elevated serum alkaline phosphatase (ALP), a GPI-anchored enzyme, in all three affected children.

74 We report that glycosylphosphatidylinositol (GPI)-anchored ephrin-As function as "reverse" signaling

75 mer comprising glycosylphosphatidylinositol (GPI)-anchored expression site-associated gene 6 (ESAG6 o

76 We recently reported that GPI anchoring facilitated the induction of Sup35(GPI) pr

77 Our results indicate the GPI anchoring facilitates the penetration of M. oryzae i

78 Exchanging the GPI anchor for a nonraft transmembrane sequence redirect

79 ure N-linked glycans and did not require the GPI anchor for localization.

80 l cell lines were generated that expressed a GPI-anchored form of a model amyloidogenic protein, the

81 e required for glycosylphosphatidylinositol (GPI) anchor formation, as a strong candidate.

82 In contrast, PrP(C) containing a GPI anchor from which the sialic acid had been removed (

83 s and following the C-terminal addition of a GPI-anchor (from surface antigen EtSAG1) mCherry was exp

84 Ret also mediates GPI-anchored GFRalpha1 signaling in response to GDNF, a

85 Incorporation of GPI-anchored GIFT4 into VLPs as a molecular adjuvant rep

86 Despite possessing high levels of GPI-anchored glycoconjugates, SMT-null mutants showed si

87 ication of the glycosylphosphatidylinositol (GPI)-anchored glycoprotein Juno as the egg plasma membra

88 By revisiting CD90, a GPI-anchored glycoprotein, we show that CD90 is expresse

89 at TbRFT1 plays a direct or indirect role in GPI anchor glycosylation in the Golgi apparatus.

90 and functional synaptogenesis, including the GPI-anchored heparan sulfate proteoglycan (HSPG) Wnt co-

91 ith Wnts, these glycosophosphotidylinositol (GPI)-anchored, heparan-sulfate proteoglycans bind ligand

92 ignaling network and, furthermore, highlight GPI-anchor hydrolysis as a cell-intrinsic mechanism to a

93 of CD45, could functionally substitute for a GPI anchor in BST-2.

94 Here, we reveal the roles of the GPI anchoring in Magnaporthe oryzae during plant infecti

95 Defects in the biosynthesis of GPI anchors in humans lead to inherited glycosylphosphat

96 wn function as glycosylphosphatidylinositol (GPI) anchors in different kingdoms of life.

97 T mice, underscoring the pivotal role of the GPI-anchor in driving the aggregate conformation and dis

98 The role of the GPI-anchor in prion disease pathogenesis is still a chal

99 The type G nsLTPs (LTPGs) have a GPI-anchor in the C-terminal region which attaches the p

100 Lymphocyte antigen 6E (LY6E) is a GPI-anchored, interferon-inducible protein that has been

101 The GPI anchor is attached to the protein in the endoplasmic

102 Its GPI anchor is modified by the addition of 4-6 alpha-gala

103 The glycosylphosphatidylinositol (GPI) anchor is a lipid and glycan modification added to

104 The glycosylphosphatidylinositol (GPI) anchor is a post-translational modification added t

105 GPI-anchoring is a universal and critical post-translati

106 FLA4 is likely to be GPI-anchored, is highly N-glycosylated and carries two O

107 viruses internalized by cells expressing the GPI-anchored isoform (TVA800) were uniformly distributed

108 nsisting of the glycerophosphatidylinositol (GPI)-anchored, ligand binding receptor GDNF family recep

109 lum (ER), the glycosyl phosphatidylinositol (GPI)-anchor likely functions as a forward transport sign

110 ta1,6-glucans and that retain their original GPI anchor lipid.

111 had significantly reduced levels of the two GPI anchor markers, CD59 and a GPI-binding toxin, aeroly

112 GAP3, encoding a protein that is involved in GPI-anchor maturation.

113 P modifications, including glycosylation and GPI anchoring, may also influence cross-species infectiv

114 Reck, a GPI-anchored membrane protein, and Gpr124, an orphan GPC

115 em are moderated by lynx proteins, which are GPI-anchored membrane proteins forming tight association

116 CD59 is a GPI-anchored membrane regulator of complement expressed

117 ed a novel parasite ligand, Plasmodium vivax GPI-anchored micronemal antigen (PvGAMA), that bound hum

118 ibility that pharmacological modification of GPI anchors might constitute a novel therapeutic approac

119 ch contains just two Mmps (secreted Mmp1 and GPI-anchored Mmp2) and one secreted Timp.

120 contain GPI-anchors, and unexpectedly, that GPI-anchored MMPs promote cell adhesion when they are re

121 In fact, attempts to demonstrate GPI anchor modification of human BST-2 by biochemical me

122 We replaced the GPI anchor motif in BST-2 with the TM regions of several

123 nd a predicted glycosylphosphatidylinositol (GPI) anchor motif.

124 ive C-terminal glycosylphosphatidylinositol (GPI) anchor motif.

125 Signaling by the GPI anchor mutant also depended on Y6 of BST2.

126 turated acyl-chains are required for forming GPI-anchor nanoclusters.

127 Using flow cytometry, GPI-anchor negative erythrocytes (mutants) were scored a

128 expression of glycosylphosphatidylinositol (GPI)-anchored nonsignaling receptors further improved pa

129 it contains a GPI anchor, ruling out that a GPI anchor obstructs ERAD.

130 nterface and further suggest that preventing GPI anchoring of CaValpha2delta1 averts its cell-surface

131 propagation and selection can be affected by GPI anchoring of the host's PrP(C).

132 Glycosylphosphatidylinositol (GPI) anchoring of proteins to the cell surface is import

133 Glycosylphosphatidylinositol (GPI) anchoring of the prion protein (PrP(C)) influences

134 or the discovery of antifungal inhibitors of GPI-anchoring of proteins, and identify the oligocyclopr

135 Thus, the lack of the GPI anchor on prions reduced the effect of the mouse-hum

136 Thus, the lack of the GPI anchor on the PrPres from tg44 mice appeared to redu

137 this study, we tested the effect of lack of GPI anchoring on a species barrier model using mice expr

138 Previous in vivo studies on the effects of GPI anchoring on prion infectivity have not examined cro

139 expression of glycosylphosphatidylinositol (GPI) anchors on their cell surface, allowing quantificat

140 Disruption of GPI7, a GPI anchor-pathway gene, led to a significant reduction

141 A library encoding approximately 100 diverse GPI-anchored peptide toxins (t-toxins) derived from spid

142 itive to loss of lynx function, and that the GPI anchor plays a role in the normal function of the ly

143 Glycosylphosphatidylinositol (GPI) anchoring plays key roles in many biological proces

144 n prion disease is due to the replication of GPI-anchored prions, with fibrillar plaques forming from

145 GPI anchor protein deficiency is almost always due to so

146 Furthermore, sgRNA targeting GPI anchor protein pathway genes induced loss of functio

147 LEI (LRE)-LIKE GLYCOSYLPHOSPHATIDYLINOSITOL (GPI)-ANCHORED PROTEIN 1 (LLG1) to regulate immune signal

148 tic changes in glycosylphosphatidylinositol (GPI)-anchored protein arrangement under varying perturba

149 CD177 is a glycosylphosphatidylinositol (GPI)-anchored protein expressed by a variable proportion

150 MDS1), and the glycosylphosphatidylinositol (GPI)-anchored protein LLG1 as regulators of mekk1-mkk1/2

151 Ly6G is a glycosylphosphatidylinositol (GPI)-anchored protein of unknown function that is common

152 or (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, t

153 hich encodes a glycosylphosphatidylinositol (GPI)-anchored protein thought to be involved in ascospor

154 romoter of the glycosylphosphatidylinositol (GPI)-anchored protein Thy1 have been widely used to exam

155 uch as CD14, a glycosylphosphatidylinositol (GPI)-anchored protein to the plasma membrane important f

156 k a transmembrane domain, myristoylation and GPI-anchor protein modifications.

157 ol-anchored proteins (GPI-APs), LORELEI-like-GPI-anchored protein 2 (LLG2) and LLG3, as co-receptors

158 FRalpha is a GPI-anchored protein and a component of the caveolae fra

159 direct interaction between p24delta5 and the GPI-anchored protein arabinogalactan protein4 (AGP4).

160 on channel protein in any tissue, and that a GPI-anchored protein associates with an HCN channel subu

161 tors, including folate receptor (FR) beta, a GPI-anchored protein belonging to the folate receptor fa

162 whereas a small number are restricted to the GPI-anchored protein CD59 for initial membrane recogniti

163 he X-chromosomal gene PIGA is known to cause GPI-anchored protein deficiency, 2 such hits are require

164 In spite of its importance for GPI-anchored protein functions, our current knowledge of

165 ere critical for rapid endocytosis because a GPI-anchored protein induced to misfold at the cell surf

166 sting of two CrRLK1Ls LET1, LET2/MDS1, and a GPI-anchored protein LLG1 that regulates the activation

167 GPIHBP1, a GPI-anchored protein of capillary endothelial cells, bin

168 analysis of maturing DCs, we identified the GPI-anchored protein semaphorin 7A (Sema7A) as being hig

169 eir physico-chemical properties, to regulate GPI-anchored protein transport and maintain homeostasis

170 ptor-like kinases and the SOS5 extracellular GPI-anchored protein were shown previously to act on a p

171 t seen after cross-linkage of Thy-1, another GPI-anchored protein, and were dependent on the GPI anch

172 sis requires the interaction of CR3 with the GPI-anchored protein, CD14, independently of TLR/MyD88-i

173 utility analyzing antibodies against CD52, a GPI-anchored protein, in its native membrane environment

174 ses, which uniquely involve aggregation of a GPI-anchored protein, versus other protein misfolding di

175 ses/LORELEI-like GLYCOLPHOSPHATIDYLINOSITOL (GPI)-ANCHORED PROTEINS (LLG) complexes, or by leucine-ri

176 Glycosylphosphatidylinositol (GPI)-anchored proteins are critical for embryogenesis, n

177 Glycosylphosphatidylinositol (GPI)-anchored proteins are important for virulence of ma

178 Glycosylphosphatidylinositol (GPI)-anchored proteins are ubiquitously expressed in the

179 bility to shed glycosylphosphatidylinositol (GPI)-anchored proteins from the cell surface.

180 n nature, many glycosylphosphatidylinositol (GPI)-anchored proteins localize in the lipid rafts.

181 Glycosylphophatidylinositol (GPI)-anchored proteins play important roles in many biol

182 absence of two glycosylphosphatidylinositol (GPI)-anchored proteins, CD55 and CD59, leads to uncontro

183 he cleavage of glycosylphosphatidylinositol (GPI)-anchored proteins, disrupted plasma membrane locali

184 ma membrane of glycosylphosphatidylinositol (GPI)-anchored proteins.

185 the sorting of glycosylphosphatidylinositol (GPI)-anchored proteins.

186 y stained for glycosyl phosphatidylinositol (GPI)-anchored proteins; CD55 and CD59.

187 There were significantly reduced levels of GPI-anchored proteins (CD55 and CD59) on the surface of

188 g lead to decreased cell surface presence of GPI-anchored proteins (GPI-APs) and cause inherited GPI

189 GPI-anchored proteins (GPI-APs) are essential for plant

190 teristics of fluorescent lipid analogues and GPI-anchored proteins (GPI-APs) in the live-cell plasma

191 re involved in biosynthesis and transport of GPI-anchored proteins (GPI-APs).

192 We show that diffusion of GPI-anchored proteins also becomes temperature dependent

193 teins, which are receptors for the export of GPI-anchored proteins and have been shown to bind a spec

194 iscriminate between plasma membrane-resident GPI-anchored proteins and those transferred to the cell

195 Thus cell surface diffusion of GPI-anchored proteins and transmembrane proteins that as

196 In an effort to identify GPI-anchored proteins and understand the possible role o

197 ortant for various biological processes, but GPI-anchored proteins are difficult to study.

198 teins are degraded by proteasomes, misfolded GPI-anchored proteins are primarily degraded in lysosome

199 observed in the Deltagpi7 mutant, indicating GPI-anchored proteins are required for immune evasion.

200 ng which time it may cleave approximately 10 GPI-anchored proteins before dissociating.

201 tabolic engineering of cell-surface GPIs and GPI-anchored proteins by using inositol derivatives carr

202 R itineraries that not only shield misfolded GPI-anchored proteins during their trafficking, but also

203 In contrast, we find that GPI-anchored proteins exhibit temperature-independent di

204 rom Clostridium septicum was used to capture GPI-anchored proteins from human breast cancer tissues,

205 lable individual samples showed that several GPI-anchored proteins had decreased cell-surface abundan

206 proteins are GPI-anchored, and disruption of GPI-anchored proteins impairs cell wall integrity.

207 Removal of GPI-anchored proteins in the wild-type strain by hydrofl

208 The loss of certain GPI-anchored proteins is hypothesized to provide the mut

209 In fungi, the final destination of many GPI-anchored proteins is their outermost compartment, th

210 ion of cholesterol-dependent nanoclusters of GPI-anchored proteins mediated by membrane-adjacent dyna

211 We found that GPI-anchored proteins mostly localized to the ER in p24d

212 ass spectrometry demonstrated that the major GPI-anchored proteins of T. brucei procyclic forms have

213 erocomplexes of CrRLK1L receptor kinases and GPI-anchored proteins of the LRE and LLG family.

214 inds to phosphatidylcholine (PC) and cleaves GPI-anchored proteins off eukaryotic plasma membranes.

215 To elucidate how BtPI-PLC searches for GPI-anchored proteins on the membrane surface, we measur

216 mechanism of peptide perception in plants by GPI-anchored proteins that act together with a phylogene

217 The plasma membrane localization of GPI-anchored proteins was restored in the p24delta3delta

218 The GPI-anchored proteins were found to highly accumulate in

219 The azide-labeled GPIs and GPI-anchored proteins were then tagged with biotin on li

220 The strategy can be used to label GPI-anchored proteins with various tags for biological s

221 ated by lipid packing defects, possibly near GPI-anchored proteins, and the protein diffuses on the m

222 GPI-anchored proteins, candidate cargoes for alternate p

223 activated exocytosis of vesicles containing GPI-anchored proteins, increasing membrane area and phag

224 Notch signalling through surface cleavage of GPI-anchored proteins, is targeted by Prdx4 oxidative ac

225 es have been implicated in the biogenesis of GPI-anchored proteins.

226 s enzyme, leading to reduced accumulation of GPI-anchored proteins.

227 ial effects on the uptake of transferrin and GPI-anchored proteins.

228 port and transport to the plasma membrane of GPI-anchored proteins.

229 IGA-null cells showed partial restoration of GPI-anchored proteins.

230 osis that requires the direct cooperation of GPI-anchored proteins.

231 malian cells recognize and degrade misfolded GPI-anchored proteins.

232 ls showed decreased cell surface presence of GPI-anchored proteins.

233 the plasma membrane by examining the flow of GPI-anchored proteins.

234 protein partially rescued the deficiency of GPI-anchored proteins.

235 ngth influences the diffusion coefficient of GPI-anchored proteins: smaller proteins diffuse faster t

236 is of glycosylphosphatidylinisotol-anchored (GPI-anchored) proteins.

237 overexpressing glycosylphosphatidylinositol (GPI)-anchored PrP(C).

238 rion infection where cells expressing either GPI-anchored PrP(C) or transmembrane-anchored PrP(C), wh

239 Only GPI-anchored PrP(C) supported persistent PrP(res) propag

240 ential influence of endogenous expression of GPI-anchored PrP(C) To further explore these questions,

241 he prion protein, PrP(res) We show that only GPI-anchored PrP(C) was able to convert to PrP(res) and

242 e to segregation of transmembrane PrP(C) and GPI-anchored PrP(res) in distinct membrane environments.

243 ion of PrP(C) gives rise to glycosylated and GPI-anchored PrP(Sc) The question of the sialylation sta

244 intact, glycophosphatidylinositol-anchored (GPI-anchored) PrP was relatively unchanged, forming diff

245 ns interact with eosinophils through CD48, a GPI-anchored receptor important in allergy mainly as exp

246 We describe GlycoFRET for a GPI-anchored receptor, a G-protein-coupled receptor, and

247 izes soluble ICs through a mechanism used by GPI-anchored receptors and fluid-phase endocytosis.

248 either an acyl chain or sialic acid from the GPI anchor reduced the targeting of PrP(C) to synapses.

249 Thus, GPI anchor remodeling is independent of protein folding

250 s cytotoxicity by targeting Cdc1 activity in GPI-anchor remodeling in the ER.

251 se cell division control protein 1 (Cdc1) in GPI-anchor remodeling is the key target of CTD, independ

252 results confirm the importance of the later GPI-anchor remodelling steps for normal neuronal develop

253 cal assays with BiPNHP, a non-N-glycosylated GPI-anchored reporter.

254 Biosynthesis and remodeling of the GPI anchor requires the activity of over 20 distinct gen

255 ERAD and provide evidence that it contains a GPI anchor, ruling out that a GPI anchor obstructs ERAD.

256 IFT4 was constructed by fusing a glycolipid (GPI)-anchoring sequence and incorporated into Env-enrich

257 ed BdBGLC2 (Bd2g51280), which has a putative GPI-anchor sequence, was found associated with the plasm

258 n (Asn514) and glycosylphosphatidylinositol (GPI) anchor (Ser529) sites.

259 inked with the glycosylphosphatidylinositol (GPI)-anchored serine protease prostasin, which is a co-f

260 of T. brucei procyclic forms have truncated GPI anchor side chains in TbRFT1 null parasites when com

261 ation but also glycosylphosphatidylinositol (GPI) anchor side-chain modification.

262 chimeric protein, indicating that the BST-2 GPI anchor signal can function as a bona fide TM region.

263 placing the TM region of CD4 by the putative GPI anchor signal of human BST-2 resulted in proper memb

264 cts containing either a C-terminal wild-type GPI anchor signal sequence or a nonraft transmembrane se

265 BST2 with a glycosylphosphatidylinositol (GPI) anchor signal deletion, which is not expressed at t

266 nd appending a glycosylphosphatidylinositol (GPI) anchor signal sequence followed by GPI-phospholipas

267 r degradation, leading to predictions that a GPI anchor sterically obstructs ERAD.

268 by altering signaling cascades downstream of GPI-anchored substrate cleavage.

269 subfamily catalyze the essential transfer of GPI-anchored substrates from the plasma membrane to the

270 hich do not attach EtN-P to mannose 1 of the GPI anchor, suggesting that Cdc1 removes the EtN-P added

271 ndent upon its glycosylphosphatidylinositol (GPI) anchor, suggesting that it is the increased density

272 However, GPI-anchored Sup35 aggregates were not stained with amyl

273 des a putative glycosylphosphatidylinositol (GPI)-anchored surface protein with a modified eight-cyst

274 alities in the synthesis and localization of GPI-anchored surface molecules.

275 PIGA is essential for GPI anchor synthesis, whereas PIGT is essential for atta

276 n genes of the glycosylphosphatidylinositol (GPI) anchor synthesis pathway.

277 t involves GDE2-mediated surface cleavage of GPI-anchored targets to inhibit Dll1-Notch signaling.

278 in and PAR-2 are co-expressed in HeLa cells, GPI-anchored testisin specifically releases the PAR-2 te

279 nnose 2 of the glycosylphosphatidylinositol (GPI) anchor, thus permitting efficient endoplasmic retic

280 tensive post-translational processing of the GPI anchor to a form that was TL/ECL-reactive, suggestin

281 , a Cys protease that transfers an assembled GPI anchor to proteins.

282 essential for attachment of the preassembled GPI anchor to proteins.

283 GPI transamidase complex, which attaches the GPI anchor to proteins.

284 s complex orchestrates the attachment of the GPI anchor to the C terminus of precursor proteins in th

285 ransamidase (GPIT), the enzyme that attaches GPI anchors to proteins as they enter the lumen of the e

286 ttachment of a glycosylphosphatidylinositol (GPI) anchor to C-terminal omega-peptides, which are used

287 P linked via a glycosylphosphatidylinositol (GPI) anchor to the cell membrane (mGFP-GPI).

288 pe mice to determine the contribution of the GPI-anchor to the molecular mass and isoelectric point o

289 In addition, GPI anchor-truncated tetherin exhibited a dominant-negat

290 the C-terminal glycosylphosphatidylinositol (GPI) anchor-truncated form, inhibited HBV virion egress

291 synthesized and attached to target proteins, GPI anchors undergo modification on lipid moieties.

292 We studied the effect of PrP GPI anchoring using a mouse-to-human species barrier mod

293 In the present study, we developed GPI-anchored variable regions (VHHs) of two heavy chain-

294 re a family of glycosylphosphatidylinositol (GPI)-anchored VGCC-associated subunits that, in addition

295 we constructed glycosylphosphatidylinositol (GPI)-anchored VHH JM2 and JM4 along with an E4 control a

296 It has several glycosylphosphatidylinositol (GPI)-anchored virulence factors.

297 RAD is caused by canonical remodeling of its GPI anchor, which occurs in all GPI-APs and provides a p

298 Given the structural specificity of fungal GPI-anchors, which is different from humans, understandi

299 n of tetherin requires the carboxyl-terminal GPI anchor, while the GPI anchor deletion mutant exhibit

300 ) by enzymatically cleaving its cell-surface GPI anchor yielded similar effects.