ライフサイエンスコーパス: GTP cyclohydrolase

1 ic amino acid dopa decarboxylase (AADC), and GTP cyclohydrolase 1 (CH1) in a single transcription uni

2 Endothelium-targeted overexpression of GTP cyclohydrolase 1 (GCH), the rate limiting enzyme in

3 GTP cyclohydrolase 1 (GCH1) and its product tetrahydrobi

4 The discovery of GTP cyclohydrolase 1 (GCH1) as a genetic risk factor for

5 The Parkinson's disease (PD) risk gene GTP cyclohydrolase 1 (GCH1) catalyzes the rate-limiting

6 Here we report that reduction of cardiac GTP cyclohydrolase 1 (GCH1) degradation by genetic and p

7 GTP cyclohydrolase 1 (GCH1) is rate limiting in the prov

8 GTP cyclohydrolase 1 (GCH1) is the rate-limiting enzyme

9 The rate limiting step for BH4 production is GTP Cyclohydrolase 1 (GCH1).

10 no-associated viruses expressing human TH or GTP cyclohydrolase 1 (GTPCH1) were injected into the str

11 g adeno-associated viruses expressing TH and GTP cyclohydrolase 1 (GTPCH1).

12 terin (a BH4 precursor) or overexpression of GTP cyclohydrolase 1 (the rate-limiting enzyme for BH4 b

13 unctional adhesion molecule-like protein and GTP cyclohydrolase 1 feedback regulatory protein, staine

14 studies have revealed an association between GTP cyclohydrolase 1 polymorphisms, which decrease tetra

15 GTP cyclohydrolase 1, encoded by the GCH1 gene, is an es

16 BH4 is regulated by GTP cyclohydrolase 1, the rate-limiting enzyme in BH4 bi

17 tent of this biopterin increases with age in GTP cyclohydrolase 1-deficient hyperphenylalaninemia-1 (

18 We have studied the GTP-cyclohydrolase 1 (GCH-1) gene in 30 patients with th

19 GTP-cyclohydrolase 1 (GTP-CH1) catalyzes the first step

20 BH4, oxidised biopterins, GTP-cyclohydrolase 1 (GTPCH-1, the rate-limiting enzyme

21 ent secondary to trangenic overexpression of GTP-cyclohydrolase 1) and reversed in wild-type mice rec

22 nterference RNA (siRNA)-mediated "knockdown" GTP cyclohydrolase-1 (GTPCH1), the rate-limiting enzyme

23 t the expression of an unregulated bacterial GTP cyclohydrolase-1 in plants would increase pterin bio

24 The expression of bacterial GTP cyclohydrolase-1 in transgenic Arabidopsis resulted

25 The folE gene encoding GTP cyclohydrolase-1 was cloned from Escherichia coli an

26 We postulated that GTP cyclohydrolase-1, which catalyzes the first committe

27 duced elevations in tyrosine hydroxylase and GTP cyclohydrolase activities.

28 We previously reported that deficits in GTP cyclohydrolase activity in Drosophila heterozygous f

29 es of the interaction include an increase in GTP cyclohydrolase activity, with concomitant protection

30 mes that regulate biopterin bioavailability, GTP cyclohydrolase and dihydrofolate reductase exhibited

31 te analogues and inhibitors suggest that the GTP cyclohydrolase and pyrophosphate phosphohydrolase ac

32 s suggest that both tyrosine hydroxylase and GTP cyclohydrolase are induced in a coordinate and trans

33 ueF exhibits sequence homology to the type I GTP cyclohydrolases characterized by FolE, but contrary

34 exhibits significant homology to the type I GTP cyclohydrolases characterized by FolE.

35 Dominantly inherited guanosine triphosphate (GTP)-cyclohydrolase deficiency, otherwise known as Segaw

36 ize biogenic amine and BH4 metabolism in the GTP cyclohydrolase deficient hph-1 mouse.

37 Instead, it uses a new type of thermostable GTP cyclohydrolase enzyme that produces 2-amino-5-formyl

38 no recognizable homologues of the canonical GTP cyclohydrolase enzymes that are required for ribofla

39 which is much faster than those of canonical GTP cyclohydrolase enzymes.

40 s end-product BH(4) via interaction with the GTP cyclohydrolase feedback regulatory protein (GFRP).

41 y for the rate-limiting BH4 synthetic enzyme GTP cyclohydrolase (GCH) became undetectable in the swea

42 Endothelium-targeted overexpression of GTP cyclohydrolase (GCH) I increased levels of the endot

43 GTP cyclohydrolase (GCH) III from Methanocaldococcus jan

44 We report that GTP cyclohydrolase (GCH1), the rate-limiting enzyme for

45 GTP-cyclohydrolase (gch1), the first enzyme in this path

46 transduction with nitric oxide synthase with GTP cyclohydrolase genes.

47 BH4 synthesis is controlled enzymatically by GTP cyclohydrolase (GTPCH), we used GTPCH-depleted mice

48 creases H4B levels and enzymatic activity of GTP cyclohydrolase (GTPCH)-1, the first step of H4B bios

49 t whether AMPK suppresses the degradation of GTP-cyclohydrolase (GTPCH I), a key event in vascular en

50 of pain sensitivity and chronicity, and the GTP cyclohydrolase haplotype is a marker for these trait

51 Similarly, a GTP cyclohydrolase I (fol2) mutant of yeast (Saccharomyc

52 d a similar situation in Escherichia coli: a GTP cyclohydrolase I (folE) mutant, deficient in pterin

53 matic l-amino acid decarboxylase (AADC), and GTP cyclohydrolase I (GCH1) transcription; increases str

54 Overexpression of GTP cyclohydrolase I (GCH1), the rate-limiting enzyme fo

55 GTP cyclohydrolase I (GCHI) mediates the first and commi

56 GTP cyclohydrolase I (GCYH-I) is an essential Zn(2+)-dep

57 GTP cyclohydrolase I (GCYH-I) is the first enzyme of the

58 that the first enzyme of the folate pathway, GTP cyclohydrolase I (GCYH-I), encoded in Escherichia co

59 GTP cyclohydrolase I (GTPCH I) is the rate-limiting enzy

60 BH4 levels, in part through the induction of GTP cyclohydrolase I (GTPCH I), the rate-limiting enzyme

61 5812 base pairs of rat GTP cyclohydrolase I (GTPCH) 5'-flanking region were clo

62 Recently the GTP cyclohydrolase I (GTPCH) gene was isolated as the fi

63 Inhibition of GTP cyclohydrolase I (GTPCH) has been used as a selectiv

64 GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme

65 enzyme in catecholamine (CA) biosynthesis of GTP cyclohydrolase I (GTPCH), rate-limiting enzyme in bi

66 e a selective and direct-acting inhibitor of GTP cyclohydrolase I (GTPCH), the first and rate-limitin

67 s factor alpha (TNF-alpha) without affecting GTP cyclohydrolase I (GTPCH), the rate-limiting enzyme i

68 Expression of both iNOS and GTP cyclohydrolase I (GTPCH), the rate-limiting enzyme i

69 (BH4), secondary to decreased expression of GTP cyclohydrolase I (GTPCH).

70 ihydro-d-neopterin triphosphate catalyzed by GTP cyclohydrolase I (GTPCHI).

71 Furthermore, expression of GTP cyclohydrolase I (the rate-limiting enzyme in de nov

72 otein (GFRP) mediates feedback inhibition of GTP cyclohydrolase I activity by tetrahydrobiopterin and

73 nase, arginine decarboxylase gene activator, GTP cyclohydrolase I and a repressor of purine biosynthe

74 del for the quaternary structure of GFRP and GTP cyclohydrolase I complexes.

75 Conversely, both switching off GTP cyclohydrolase I expression as well as inhibiting it

76 GTP cyclohydrolase I feedback regulatory protein (GFRP)

77 phenylalanine through complex formation with GTP cyclohydrolase I feedback regulatory protein (GFRP).

78 one and those additionally modified with the GTP cyclohydrolase I gene indicate that BH4 is critical

79 ted with fibro-blasts possessing both TH and GTP cyclohydrolase I genes displayed biochemical restora

80 To examine further the importance of GTP cyclohydrolase I in gene therapy for PD, in vivo mic

81 y a single enzyme, as is known to occur with GTP cyclohydrolase I in the Eucarya and Bacteria, but ra

82 The activity of GTP cyclohydrolase I is inhibited by (6R)-L-erythro-5,6,

83 al restoration in a rat model of PD and that GTP cyclohydrolase I is sufficient for production of BH4

84 cells with Tet-regulated expression of human GTP cyclohydrolase I to regulate intracellular BH4 avail

85 GTP cyclohydrolase I was also required for fitness in mi

86 Because GFRP is a pentamer and GTP cyclohydrolase I was shown here by cross-linking exp

87 hasone prevented the coordinate induction of GTP cyclohydrolase I with NOS2 after exposure to interle

88 We used a synthetic gene based on mammalian GTP cyclohydrolase I, because this enzyme is predicted t

89 diamino-6-hydroxypyrimidine, an inhibitor of GTP cyclohydrolase I, decreased endothelium-dependent va

90 st enzyme in the cofactor synthesis pathway, GTP cyclohydrolase I, is activated by phosphorylation an

91 omato fruit up to 140-fold by overexpressing GTP cyclohydrolase I, the first enzyme of pteridine synt

92 decline by fruit-specific overexpression of GTP cyclohydrolase I, the first enzyme of pteridine synt

93 vitro data demonstrate that NAMDA inhibited GTP cyclohydrolase I, the rate-limiting enzyme for BH4 b

94 h tetracycline-regulated expression of human GTP cyclohydrolase I, the rate-limiting enzyme in BH4 sy

95 ntameric GFRP associate with one molecule of GTP cyclohydrolase I.

96 nd stimulatory complexes is equal to that of GTP cyclohydrolase I.

97 h of the two outer faces of the torus-shaped GTP cyclohydrolase I.

98 y MptA (MJ0775 gene product), a new class of GTP cyclohydrolase I.

99 he first enzyme in its biosynthetic pathway, GTP cyclohydrolase I.

100 molog loss and suggest the importance of the GTP Cyclohydrolase I/Tetrahydrobiopterin pathway.

101 Guanosine triphosphate (GTP) cyclohydrolase I (GCH1) catalyzes the conversion of

102 transfer of human guanosine 5'-triphosphate (GTP) cyclohydrolase I (GTPCH I), the first and rate-limi

103 sis is controlled by guanosine triphosphate (GTP) cyclohydrolase I (GTPCHI) and its feedback regulato

104 um, by targeted transgenic overexpression of GTP-cyclohydrolase I (GCH), prevented hypoxia-induced pu

105 AKR1B1), carbonyl reductase (CBR1 and CBR3), GTP-cyclohydrolase I (GCH1), and 6-pyruvoyltetrahydrobio

106 he key enzyme involved in BH(4) synthesis is GTP-cyclohydrolase I (GTPCH-I), which is stimulated by e

107 ng human tyrosine hydroxylase (hTH) or human GTP-cyclohydrolase I [GTPCHI, the rate-limiting enzyme f

108 r in HPS, where activities of the key enzyme GTP-cyclohydrolase I are in the normal range, but total

109 tly increased de novo synthesis for 6BH4 via GTP-cyclohydrolase I concomitant with high levels of 6BH

110 involved in 6BH4 biosynthesis/recycling and GTP-cyclohydrolase I feedback regulatory protein were ex

111 drobiopterin bioavailability by upregulating GTP-cyclohydrolase I gene expression and activity, resul

112 ype (X haplotype) in the GCH1 gene, encoding GTP-cyclohydrolase I, the rate-limiting enzyme in biopte

113 d interacts directly with the zinc-dependent GTP cyclohydrolase IA, FolE (GCYH-IA).

114 th significant (>40%) amino acid identity to GTP cyclohydrolase II (GCH II), which catalyzes the comm

115 Three GTP cyclohydrolase II homologues in the Streptomyces coe

116 This enzyme is different than the bacterial GTP cyclohydrolase II which catalyzes both reactions.

117 he gene encoding a putative dual-functioning GTP cyclohydrolase II-3,4-dihydroxy-2-butanone-4-phospha

118 and FLU encoding the dual-functional protein GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phospha

119 n of this enzyme confirms the involvement of GTP cyclohydrolase III (ArfA) in archaeal riboflavin and

120 This activity has been reported for a GTP cyclohydrolase III protein from Methanocaldococcus j

121 proposed to begin with an archaeal-specific GTP cyclohydrolase III that hydrolyzes the imidazole rin

122 ct, but not the NGF effect, NGF also induced GTP cyclohydrolase in a cAMP-dependent manner, while the

123 Sphingosine induced GTP cyclohydrolase in a protein kinase C-independent man

124 to acetylcholine, which was inhibited by the GTP-cyclohydrolase inhibitor 2,4-diamino-6-hydroxypyrimi

125 GTP cyclohydrolase is composed of a highly conserved hom

126 re the induction of tyrosine hydroxylase and GTP cyclohydrolase is not coordinately regulated.

127 Mammalian GTP cyclohydrolase is subject to end-product inhibition

128 were additionally modified with the gene for GTP cyclohydrolase l; an enzyme critical for BH4 synthes

129 Whereas canonical GTP cyclohydrolases produce this formylamino-pyrimidine

130 Here we report the identification of a new GTP cyclohydrolase that converts GTP to 7,8-dihydro-d-ne

131 MptA is the archetype of a new class of GTP cyclohydrolases that catalyzes a series of reactions

132 Induction of GTP cyclohydrolase (the rate-limiting enzyme for the pro

133 d the activities of tyrosine hydroxylase and GTP cyclohydrolase, the rate-limiting enzymes in catecho

134 mine release, and we found that the gene for GTP cyclohydrolase, which effectively regulates TH throu

135 Expression of GTP cyclohydrolase, which produces tetrahydrobiopterin (