ライフサイエンスコーパス: GTPase-activating protein

1 igh levels of RAS-GTP had loss of NF1, a RAS GTPase activating protein.

2 in and demonstrate that FLCN acts as a Rab7A GTPase-activating protein.

3 kinesin-6 motor, and CYK-4/MgcRacGAP, a Rho GTPase-activating protein.

4 ar recycling processes, probably as a Rab11b GTPase-activating protein.

5 affold as well as an ADP-ribosylation factor-GTPase-activating protein.

6 ence and in the absence of the corresponding GTPase activating proteins.

7 k loop, and this inhibition depends on Cdc42 GTPase-activating proteins.

8 rous guanine nucleotide exchange factors and GTPase-activating proteins.

9 ere, we demonstrate that IQ motif containing GTPase activating protein 1 (IQGAP1) binds to TGF-beta r

10 the multidomain scaffold IQ motif containing GTPase activating protein 1 (IQGAP1) coordinates the act

11 IQ motif-containing GTPase activating protein 1 (IQGAP1) plays a central rol

12 affold proteins, such as IQ motif containing GTPase activating protein 1 (IQGAP1), are promising targ

13 MAPK scaffolds, such as IQ motif-containing GTPase activating protein 1 (IQGAP1), assemble pathway k

14 an ERK scaffold protein, IQ motif containing GTPase activating protein 1 (IQGAP1).

15 naling and decrease Ile Gln motif containing GTPase Activating Protein 1 phosphorylation.

16 ng adenosine diphosphate-ribosylation factor GTPase activating protein 1 revealed high reactivity fre

17 ng with HvMAGAP1 (Microtubule Associated ROP-GTPase Activating Protein 1).

18 beta-arrestin 2 and Ile Gln motif containing GTPase Activating Protein 1, a regulator of mammalian ta

19 We demonstrate that AnkB binds to Rab GTPase Activating Protein 1-Like (RabGAP1L) and recruits

20 with a scaffold protein, IQ motif-containing GTPase-activating protein 1 (IQGAP1) after ligation by i

21 ellular scaffold protein IQ motif containing GTPase-activating protein 1 (IQGAP1) as an LGR4-interact

22 IQ motif-containing GTPase-activating protein 1 (IQGAP1) is a cytoskeleton-i

23 IQ motif-containing GTPase-activating protein 1 (IQGAP1) is a scaffold prote

24 , we have shown that the IQ motif-containing GTPase-activating protein 1 (IQGAP1) provides a molecula

25 that LGR5 interacts with IQ motif-containing GTPase-activating protein 1 (IQGAP1), an effector of Rac

26 ugh the scaffold protein IQ motif-containing GTPase-activating protein 1(IQGAP1).

27 In this study, IQGAP1 (IQ motif-containing GTPase-activating protein 1), a new Nrf2 interaction par

28 dentify one such factor, IQ motif containing GTPase activating protein-1 (IQGAP1), which enhances Rho

29 the scaffolding proteins IQ motif-containing GTPase-activating protein-1 (IQGAP1) and Crk-like (CRKL)

30 iation of intronic variants in ARHGAP15 (Rho GTPase-activating protein 15; rs4662344-T: P=1.9 x 10(-1

31 egion mapping to Iqgap2 (IQ motif-containing GTPase activating protein 2) and F2rl2 (proteinase-activ

32 osteosarcoma metastasis, including Slit-Robo GTPase-Activating Protein 2 (Srgap2).

33 ontrol protein 42) and Srgap2 (SLIT-ROBO Rho GTPase-activating protein 2).

34 (MMP12)/MMP13, catenin alpha3 (CTNNA3), rho GTPase-activating protein 24 (ARHGAP24), angiopoietin 4

35 preading through its interaction partner Rho GTPase-activating protein 29 (ArhGAP29), a GTPase activa

36 In the present study, we show that the Arf-GTPase activating protein-3 (ArfGAP3), a well characteri

37 homolog, but not its mutant defective in Ras GTPase activating protein activity, reverses miR-431's e

38 an RGS domain, responsible for the canonical GTPase activating protein activity, RGS2 can regulate ad

39 sequence that was capable of enhancing RGS7 GTPase-activating protein activity in solution by an all

40 ted PLC-beta3 activation and for the Galphaq GTPase-activating protein activity of PLC-beta.

41 The RGS domain of RGS6, known only for its GTPase-activating protein activity toward Galpha subunit

42 Overexpression of SNX26 resulted in a GTPase-activating protein activity-dependent decrease in

43 indicate that KNR6 can interact with an Arf GTPase-activating protein (AGAP) and its phosphorylation

44 s for control of the cytoskeleton by the Arf GTPase-activating protein AGAP1 has not been characteriz

45 t53) or overexpressing Msb3, a Rab5-directed GTPase-activating protein, all exhibit pronounced reduct

46 ry data for the ARF family GTPases and their GTPase--activating proteins allowed the generation of hy

47 Here, we demonstrate that the Rho-GTPase-activating protein alpha2-chimaerin is specifical

48 he unexpected pro-oncogenic functions of Rac GTPase-activating proteins also challenged the dogma tha

49 sensitivity to mutation when regulated by a GTPase activating protein and a nucleotide exchange fact

50 , including Arf6 (ADP ribosylation factor 6) GTPase activating proteins and clathrin, while CLIC4 ove

51 TBC1 domain family member 1 (TBC1D1), a Rab GTPase-activating protein and paralogue of Akt substrate

52 Tuberin (TSC2) is a GTPase-activating protein and prominent intrinsic regula

53 DLC1 encodes a RhoA GTPase-activating protein and tumor suppressor lost in c

54 GTPase-activating protein and VPS9 domain-containing pro

55 r Raf and concomitantly increases binding to GTPase-activating proteins and the rate of GTP hydrolysi

56 SYNGAP1, a synaptic Ras GTPase activating protein, and SHANK3, a synaptic scaffo

57 he NF1 gene encodes for neurofibromin, a RAS GTPase-activating protein, and thus negatively regulates

58 NEDD9 directly binds to Arf6-GTPase-activating protein, ARAP3 and Arf6-effector GGA3,

59 These Rac-GTPase activating proteins are regulated by the lipid se

60 The Arf GTPase-activating protein (Arf GAP) with SH3 domain, ank

61 ctors (ARF GEFs) that activate them, and the GTPase-activating proteins (ARF GAPs) that have the abil

62 Here, we show that the Arf GTPase-activating protein (ArfGAP) Gcs1 is a Drs2 effect

63 , the protein ADAP1 (ADP-ribosylation factor GTPase-activating protein [ArfGAP] with dual pleckstrin

64 Together with GTPase-activating proteins (ArfGAPs) and guanine exchang

65 prising the Cdc42-interactor IQGAP1, the Rho GTPase-activating protein ARHGAP10, and the integrin int

66 ivator, whereas actin polymerization and the GTPase-activating protein ArhGAP15 are essential for pro

67 d in the identification of the Rac1-specific GTPase-activating protein ARHGAP17 and the guanine nucle

68 pheroids of human cells, we identify the Rho GTPase activating protein ARHGAP18 as an effector of YAP

69 eta-Arrestin1 binds and suppresses the Cdc42 GTPase-activating protein ARHGAP21, we hypothesize that

70 strated that selective expression of the Rho GTPase-activating protein ARHGAP42 in smooth muscle cell

71 A proteomics analysis identified the Rab43 GTPase-activating protein as a downstream target of Akt.

72 here that Rab10 is a bona fide target of the GTPase-activating protein AS160, which is inhibited afte

73 The Ras GTPase-activating protein-binding protein G3BP1 is a cen

74 during interphase by the essential bipartite GTPase-activating protein Byr4-Cdc16.

75 kinesin-6 forms a complex with a Rho-family GTPase-activating protein called MgcRacGAP to signal to

76 in the NF1 tumor suppressor, which encodes a GTPase-activating protein called neurofibromin that nega

77 through its domain structure, SRGAP2A, a Rho-GTPase-activating protein, can co-regulate excitatory an

78 i-allelic variants in RALGAPA1 (encoding Ral GTPase activating protein catalytic alpha subunit 1) in

79 ate of GTP hydrolysis via both intrinsic and GTPase-activating protein-catalyzed mechanisms, resultin

80 onstrate that Ajuba interacts with the Cdc42 GTPase activating protein CdGAP, a GAP for Rac1 and Cdc4

81 -3-3 does not alter in vitro activity of the GTPase-activating protein complex.

82 The GTPase-activating protein DEPDC1B induces ERK protein ph

83 oncoding variants in a gene that encodes the GTPase-activating protein (DLC1) are significantly assoc

84 s formation of the AKT kinase (AKT)/DLC1 Rho-GTPase-activating protein (DLC1) complex and thereby inc

85 Finally, we showed that Carabin Ras-GTPase-activating protein domain and calcineurin-interac

86 its calcineurin-interacting site and Ras/Rab GTPase-activating protein domain, functions as an endoge

87 Homeostatic sleep control requires the Rho-GTPase-activating protein encoded by the crossveinless-c

88 ] retains intrinsic GTP hydrolysis; however, GTPase-activating protein failed to accelerate hydrolysi

89 RhoA activity and its regulated GTPase-activating protein FilGAP are elevated during ear

90 equires the distal-pole tag Bud8 and Rga1, a GTPase activating protein for Cdc42, which inhibits budd

91 response to amino acids, including GATOR1, a GTPase activating protein for RAGA, and GATOR2, a positi

92 ARAP3, a GTPase activating protein for Rho and Arf family GTPases

93 o GTPase-activating protein 29 (ArhGAP29), a GTPase activating protein for Rho proteins.

94 Chimaerins, a family of GTPase activating proteins for the small G-protein Rac,

95 es of cultured hippocampal neurons, and as a GTPase-activating protein for Cdc42, it decreased the F-

96 hyphal apical dome (HAD) where it acts as a GTPase-activating protein for FgRab8 which is required f

97 Conversely, ARHGAP25, a GTPase-activating protein for Rac, was up-regulated in A

98 NF1 encodes neurofibromin, a GTPase-activating protein for RAS proto-oncogene GTPase

99 which occurs in the absence of the predicted GTPase-activating protein for Ras, leads to reduction in

100 nd tuberin form the TSC complex that acts as GTPase-activating protein for Rheb and negatively regula

101 MglB, a GTPase-activating protein, forms a cluster that responds

102 strates that the loss of DAB2IP, a novel Ras-GTPase activating protein frequently found in many cance

103 ing through Rag GTPases, and GATOR1 displays GTPase activating protein (GAP) activity for RAGA and RA

104 neurofibromin functioning as a Ras-specific GTPase activating protein (GAP) and Spred1 acting on hit

105 A key role in this process belongs to the GTPase Activating Protein (GAP) complex that catalyzes G

106 the FLCN:FNIP2 (FLCN-interacting protein 2) GTPase activating protein (GAP) complex, and prevents Ra

107 lexin signaling depends on their cytoplasmic GTPase activating protein (GAP) domain, which specifical

108 y, we demonstrate that Pex11p functions as a GTPase activating protein (GAP) for Dnm1p in vitro.

109 C1 signaling by interacting with GATOR1, the GTPase activating protein (GAP) for RagA/B.

110 GATOR1 is a GTPase activating protein (GAP) for RagB whereas GATOR2

111 One such regulator, FLCN-FNIP2, is a GTPase activating protein (GAP) for RagC/D, but despite

112 utations within a gene predicted to encode a GTPase activating protein (GAP) for Ras.

113 eIF5 is the GTPase activating protein (GAP) for the eIF2 . GTP . Met

114 The mammalian Tsc1-Tsc2 GTPase activating protein (GAP) heterodimer is a critica

115 anine nucleotide exchange factor (GEF) and a GTPase activating protein (GAP) is an efficient method f

116 The cognate MglA GTPase activating protein (GAP) MglB, which localizes ma

117 of the small GTPase Arl3 and its regulatory GTPase activating protein (GAP) Retinitis Pigmentosa 2 (

118 lexes regulate the Rags, including GATOR1, a GTPase activating protein (GAP), and GATOR2, a positive

119 Rapid GTPase activating protein (GAP)-mediated inactivation (R

120 ein kinase via its guanosine triphosphatase (GTPase) activating protein (GAP) activity toward the GTP

121 Arf6 and the Arf6 GTPase-activating protein (GAP) ACAP1 are established re

122 GATOR1 has GTPase-activating protein (GAP) activity for RagA and Ra

123 localizes to membrane protrusions, where its GTPase-activating protein (GAP) activity is required for

124 2 is a ~32 kDa protein first purified by its GTPase-activating protein (GAP) activity toward ARL2 and

125 GATOR1 (GTPase-activating protein (GAP) activity toward Rags-1),

126 guanine nucleotide exchange factor (GEF) and GTPase-activating protein (GAP) activity, and effector b

127 The YopE C-terminal domain has GTPase-activating protein (GAP) activity.

128 fector Raf while promoting the engagement of GTPase-activating protein (GAP) and GTP hydrolysis.

129 RAB10 and its GTPase-activating protein (GAP) AS160 comprise the princ

130 ncovered a novel role for the Cdc42-directed GTPase-activating protein (GAP) Bem2 in Cdc42 polarizati

131 We identify the Rac-specific GTPase-activating protein (GAP) breakpoint cluster regio

132 tion can rescue cytokinesis failure when the GTPase-activating protein (GAP) CYK-4 is disrupted, Rac

133 ExoT possesses an N-terminal GTPase-activating protein (GAP) domain and a C-terminal

134 cell division axis by signaling through its GTPase-activating protein (GAP) domain and Cdc42.

135 eir effects via an intracellular R-Ras/M-Ras GTPase-activating protein (GAP) domain or by activation

136 ing synaptic F-actin through its cytoplasmic GTPase-activating protein (GAP) domain.

137 1), but not guanine exchange factor (GEF) or GTPase-activating protein (GAP) enzymes, and is exclusiv

138 ology (PH) domain 1 (ASAP1) is a multidomain GTPase-activating protein (GAP) for ADP-ribosylation fac

139 igmentosa 2 polypeptide (RP2) functions as a GTPase-activating protein (GAP) for ARL3 (Arf-like prote

140 Bud2p, which functions as a GTPase-activating protein (GAP) for Bud1p/Rsr1p, is requ

141 Here we demonstrate that TBC1d5, a GTPase-activating protein (GAP) for Rab7, is a high-affi

142 TBCK is a putative GTPase-activating protein (GAP) for small GTPases of the

143 ent systematic approaches identified Rga2, a GTPase-activating protein (GAP) for the Cdc42 Rho-type G

144 synGAP is a neuron-specific Ras and Rap GTPase-activating protein (GAP) found in high concentrat

145 o show that the Saccharomyces cerevisiae Arf GTPase-activating protein (GAP) homolog Gcs1p uses a rel

146 he yeast Rab5 Vps21, which also recruits the GTPase-activating protein (GAP) Msb3.

147 eracts with the PDZ binding motif of the Rho GTPase-activating protein (GAP) Myosin-9A.

148 The Ras GTPase-activating protein (GAP) p120RasGAP inhibits Ras

149 Here, we identify the GTPase-activating protein (GAP) Rasal1 as a novel TCR-ZA

150 We identified the Rab-specific GTPase-activating protein (GAP) RN-tre as necessary for

151 b3 and Rab27 has been reported; however, the GTPase-activating protein (GAP) specific for Rab27B has

152 Neurofibromatosis type I (Nf1) is a GTPase-activating protein (GAP) that inactivates the onc

153 SynGAP is a Ras/Rap GTPase-activating protein (GAP) that is a major constitu

154 Deleted in Liver Cancer 1 (DLC1) is a RHO GTPase-activating protein (GAP) that negatively regulate

155 C negatively regulates mTORC1 by acting as a GTPase-activating protein (GAP) towards the small GTPase

156 YopE is a GTPase-activating protein (GAP) while YopT is a protease

157 SynGAP is a synaptic Ras GTPase-activating protein (GAP) with four C-terminal spl

158 ed guanine nucleotide exchange factor (GEF), GTPase-activating protein (GAP), and effector-binding sp

159 structure suggested that C9orf72-SMCR8 is a GTPase-activating protein (GAP), and we found that C9orf

160 the signaling gene RGS2, which encodes for a GTPase-activating protein (GAP), is a key regulatory hub

161 Here we demonstrate that ELMOD2, an ARL2 GTPase-activating protein (GAP), is necessary for ARL2 t

162 The myosin Myo9b, a Rho GTPase-activating protein (GAP), negatively regulates Rh

163 ented interaction with neurofibromin 1 (NF1)-GTPase-activating protein (GAP), providing a mechanism f

164 ith alanine impaired both intrinsic and TSC2 GTPase-activating protein (GAP)-mediated GTP hydrolysis

165 that arise in these precursors, and that the GTPase-activating protein (GAP)-related domain (GRD) is

166 The GTPase-activating protein (GAP)-related domain is requir

167 ically enriched Cadherin2 sequesters the Rho GTPase-activating protein, Gap21/23, to homotypic juncti

168 They achieve this by acting as GTPase activating proteins (GAPs) for Galpha subunits an

169 of Hh signaling via their ability to act as GTPase activating proteins (GAPs) for GTP-bound Galphai,

170 GTPase activating proteins (GAPs) from pathogenic bacter

171 guanine nucleotide exchange factors (GEFs), GTPase activating proteins (GAPs), and in the Rho and Ra

172 GTPase-activating proteins (GAPs) and guanine exchange f

173 chimaerin belongs to the chimaerin family of GTPase-activating proteins (GAPs) and is encoded by the

174 change factors, but essential roles for Arf1 GTPase-activating proteins (GAPs) are less clear.

175 show that the ArhGAP12- and ArhGAP32-family GTPase-activating proteins (GAPs) are RPEL proteins.

176 R) signaling through their ability to act as GTPase-activating proteins (GAPs) for activated Galpha s

177 ly identified members of the ELMOD family as GTPase-activating proteins (GAPs) for ARL2 that displaye

178 leotide exchange factors (GEFs) activate and GTPase-activating proteins (GAPs) inhibit RhoA activity.

179 eam guanine nucleotide exchange factors, and GTPase-activating proteins (GAPs) is differentially dysr

180 ss of function of two distinct RhoA-specific GTPase-activating proteins (GAPs) leads to opposite neur

181 Rabs are regulated by GTPase-activating proteins (GAPs), activating the hydrol

182 guanine nucleotide exchange factors (GEFs), GTPase-activating proteins (GAPs), and also post-transla

183 Rab activity is modulated in part by GTPase-activating proteins (GAPs), and many RabGAPs shar

184 At least six ADP-ribosylation factor (Arf) GTPase-activating proteins (GAPs), including ARAP2 (an A

185 mote inclusion of cytosine-rich exons within GTPase-activating proteins (GAPs), negative regulators o

186 e nucleotide dissociation inhibitors (GDIs), GTPase-activating proteins (GAPs), or the chaperone/GEF

187 This GTPase is negatively regulated by the GTPase-activating proteins (GAPs), which are important f

188 activities of Rho GTPases are stimulated by GTPase-activating proteins (GAPs), which contain a RhoGA

189 anine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), which partner with on

190 anine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs).

191 Ras GTPase activity and confer resistance to GTPase-activating proteins (GAPs).

192 e factors (GEFs) and negatively regulated by GTPase-activating proteins (GAPs).

193 ic guanine exchange factors (GEFs) and their GTPase-activating proteins (GAPs).

194 uanine nucleotide exchange factors [GEFs] or GTPase-activating proteins [GAPs]) are involved in coord

195 biquitin ligases and GTPase exchange factors/GTPase-activating proteins (GEF/GAP).

196 ppressor homolog (LATS), and we identify the GTPase-activating protein GIT ArfGAP 1 (GIT1) as an SRC

197 SynGAP is a Ras-GTPase activating protein highly enriched at excitatory

198 ific target, suggesting a role for this host GTPase-activating protein in Coxiella infections.

199 We show that ELMOD1 is a GTPase-activating protein in hair cells for the small GT

200 th its binding partner ARHGAP35/P190A, a RHO GTPase-activating protein, in the radial glia-like neura

201 r, a dual guanine nucleotide exchange factor-GTPase-activating protein, in this process.

202 roteins from brain identifies Graf1c, a RhoA GTPase-activating protein inhibited by Pyk2.

203 creased steady state levels of Tbc1d1, a RAB-GTPase activating protein involved in Glucose 4 transpor

204 ysin/Rvs (F-BAR) Cdc15p, IQ motif containing GTPase-activating protein (IQGAP) Rng2p, and formin Cdc1

205 IQ motif-containing GTPase-activating protein (IQGAP) scaffolding proteins r

206 urofibromin, a tumor suppressor and Ras-GAP (GTPase-activating protein), is also an estrogen receptor

207 Here we show that ArhGAP30, a Rho GTPase-activating protein, is a pivotal regulator for p5

208 ELMOD3, an ARL2 GTPase-activating protein, is implicated in causing hear

209 TBC1D8B is an uncharacterized Rab-GTPase-activating protein likely involved in endocytic a

210 of MeaB is incomplete in the absence of the GTPase-activating protein MCM and therefore unable to st

211 ng caused by depletion of male germ cell Rac GTPase-activating protein (MgcRacGAP), a component of th

212 exception of the Crossveinless-c (Cv-c) Rho GTPase-activating protein, most effectors exert little m

213 efect of macrophages lacking the RhoGAP (Rho GTPase-activating protein) myosin IXb (Myo9b).

214 tions in the NF1 gene, which encodes the RAS GTPase-activating protein neurofibromin.

215 lex containing the spine regulator Rac1, its GTPase-activating protein neuron-associated developmenta

216 4, which encodes the ADP ribosylation factor GTPase-activating protein nevershed/AGD5.

217 MglB, the GTPase-activating protein of MglA, regulates motor rever

218 In this paper, we report that RasGAP (GTPase-activating protein of Ras) prevented indirect act

219 m involves p120 catenin interaction with Rho GTPase activating protein (p190RhoGAP), leading to p190R

220 known target of miRNA-132 is the Rho family GTPase-activating protein, p250GAP.

221 stically, FAK co-immunoprecipitated with the GTPase-activating protein p85alpha in a phosphorylation

222 PLC-beta isoforms also function as GTPase-activating proteins, potentiating Gq deactivation

223 Rga1, a Cdc42 GTPase-activating protein, prevents budding within the d

224 ine nucleotide exchange factors) and RhoGAP (GTPase activating proteins), proteins that control the a

225 emonstrate that TBC1D15, a mitochondrial Rab GTPase-activating protein (Rab-GAP), governs autophagoso

226 Expression of the Rab3 GTPase activating protein, Rab3Gap1, was restored in Ppp

227 Overexpression of a specific subset of Rab GTPase-activating proteins (RabGAPs) inhibited histamine

228 esides on chromatin, and the cytoplasmic Ran GTPase activating protein RanGAP.

229 The Ran GTPase activating protein (RanGAP) is important to Ran s

230 Its localization is tightly regulated by the GTPase-activating protein RanGAP1 and the nuclear guanos

231 en characterized as a coactivator of the Ran GTPase-activating protein RanGAP1.

232 ce of the widespread down-regulation of Rap1 GTPase-activating protein (Rap1GAP), a negative regulato

233 Neurofibromin exhibits Ras GTPase activating protein (Ras-GAP) activity that is tho

234 y reduced by silencing expression of the Ras-GTPase activating protein (Ras-GAP) neurofibromin, a 5-H

235 Loss of the RAS GTPase-activating protein (RAS-GAP) NF1 drives aberrant

236 demonstrate that RASAL2, which encodes a RAS-GTPase-activating protein (RAS-GAP), is a functional tar

237 nclude functional alteration of GTPases, Ras GTPase-activating proteins, Ras guanine exchange factors

238 Yeast 2-hybrid analyses identified the Ras GTPase-activating protein Rasa1, a known regulator of ly

239 ect found in our previous studies of the Ras GTPase activating protein (RasGAP) and the elongation fa

240 key regulator of this cascade is the Nf1 Ras GTPase activating protein (RasGAP), which attenuates Ras

241 NF1 encodes a Ras GTPase-activating protein (RasGAP) and its loss drives c

242 activated Ras by blocking recruitment of Ras GTPase-activating protein (RasGAP) to the plasma membran

243 ncluding Nck adaptor protein (Nck), p120-Ras GTPase-activating protein (RasGAP), and the alpha- and b

244 ide derived from the N2 fragment of p120 Ras GTPase-activating protein (RasGAP), sensitizes tumor cel

245 isely controlled by mechanisms involving Ras GTPase activating proteins (RasGAPs) responsible for ter

246 Ras GTPase-activating proteins (RasGAPs) inhibit signal tran

247 asal, belonging to the GAP1 subfamily of Ras GTPase-activating proteins (RasGAPs) with dual RasGAP/Ra

248 , a tumor suppressor gene that encodes a Ras-GTPase-activating protein, results in hyperactivity of R

249 (XLRP) resulting from mutations in the ARL3 GTPase activating protein, retinitis pigmentosa 2 (RP2).

250 Loss of the Cdc42 GTPase activating proteins, Rga2 and Bem3, also abolishe

251 p curvature, countering the effects of Cdc42 GTPase-activating protein Rga4.

252 tinas, immunostaining for Gbeta3 and for the GTPase activating proteins RGS7, RGS11, R9AP and Gbeta5

253 on its presence at focal adhesions, its Rho-GTPase activating protein (Rho-GAP) function, and its ab

254 rons require Crossveinless-c, a specific Rho-GTPase-activating protein (Rho-Gap), to alter their memb

255 a member of the Slit-Robo sub-family of Rho GTPase-activating proteins (Rho GAPs), controls actin an

256 , which might install platforms allowing Rho-GTPase-activating protein (RhoGAP) activity to be focuse

257 nd S567) in the DLC1 tumor suppressor, a Rho GTPase-activating protein (RhoGAP) associated with focal

258 Centralspindlin, composed of the Rho family GTPase-activating protein (RhoGAP) MgcRacGAP/CYK-4 and t

259 BPGAP1 is a Rho GTPase-activating protein (RhoGAP) that regulates cell m

260 se proteins are inactivated by Rho-selective GTPase-activating proteins (RhoGAP), which have generall

261 RHO GTPase-activating proteins (RHOGAPs) are one of the majo

262 er cancer genes (DLC1-3) encode Rho-specific GTPase-activating proteins (RhoGAPs).

263 ne nucleotide exchange factors (RhoGEFs) and GTPase-activating proteins (RhoGAPs).

264 Here, the Ras-GTPase-activating protein SH3 domain-binding protein 1 (

265 Here we report that GTPase-activating protein SH3 domain-binding protein 1 (

266 s granule responses and co-localisation with GTPase Activating Protein (SH3 domain) Binding Proteins

267 e factor (Gartenzwerg) or overexpressing its GTPAse-activating protein showed that ARF1-GTP is essent

268 lks) and degradation of spine-associated Rap GTPase-activating protein (SPAR) to reduce synaptic exci

269 ases the association of Robo1 with the Cdc42 GTPase-activating protein srGAP1.

270 Whereas ARAP1 encodes a GTPase activating protein, STARD10 is a member of the st

271 tion-based nucleotide binding, intrinsic and GTPase-activating protein-stimulated GTPase, and ARL3 gu

272 by Rab6A', even in the presence of cellular GTPase-activating proteins, suggesting that the function

273 in (FMRP) and haploinsufficiency of synaptic GTPase-activating protein (SynGAP), two prevalent monoge

274 f the orthologous Tre-2/Bub2/CDC16 (TBC) Rab GTPase-activating proteins TBC-7 and TBC1D15 in Caenorha

275 2-Cdc16 (TBC) domain-containing RAB-specific GTPase-activating proteins (TBC/RABGAPs).

276 is also required for the recruitment of the GTPase-activating protein TBC1 domain family member 5 to

277 The Rab-GTPase-activating proteins TBC1D1 and TBC1D4 (AS160) wer

278 reactivates a cryptic transcript of the Rab GTPase activating protein TBC1D16 (TBC1D16-47 kDa; refer

279 complex as a ZEB1 co-repressor and the Rab22 GTPase-activating protein TBC1D2b as a ZEB1/NuRD complex

280 interaction experiments identified the Rab7 GTPase-activating protein TBC1D5 as a candidate CstK-spe

281 essed by reducing Rab7 or overexpressing the GTPase activating protein, TBC1D5.

282 eurofibromatosis type 1 (Nf1) gene encodes a GTPase activating protein that negatively regulates smal

283 RASA1 is a GTPase-activating protein that acts as a negative regula

284 gulator of G protein signaling (RGS) Sst2, a GTPase-activating protein that dampens pheromone recepto

285 ARHGAP25 is a Rac-specific GTPase-activating protein that is expressed primarily in

286 QGAP1 binds to both RhoA and p190A-RhoGAP, a GTPase-activating protein that normally inhibits RhoA ac

287 ng to Akt substrate of 160 kD (AS160), a Rab GTPase-activating protein that regulates the trafficking

288 ion of regulator of G-protein signaling 2, a GTPase-activating protein that restricts Gaq and Gas sig

289 SYNGAP1 is a Ras GTPase-activating protein that underlies the formation a

290 dria during infection and acts as a specific GTPase-activating protein to interfere with the function

291 calcium-promoted Ras inactivator (CAPRI), a GTPase-activating protein, to the plasma membrane downst

292 The RhoGAP (GTPase--activating protein toward Rho family small GTPas

293 RC1) by the increased minichromosome loss 1/ GTPase-activating proteins toward Rags 1 (Iml1/GATOR1) c

294 ct activator of mTOR, and its inhibitor, the GTPase-activating protein tuberin (TSC2), may play a rol

295 s of a kinesin-6 motor (Pav/kinesin-6) and a GTPase-activating protein (Tum/RacGAP).

296 A Ras GTPase activating protein tumor suppressor (RasGAP), DAB

297 We discovered that DAB2IP, a novel Ras-GTPase-activating protein, was frequently epigenetically

298 SMO1 encodes a GTPase-activating protein, which regulates Ras signaling

299 Oligophrenin-1 (Ophn1) encodes a Rho GTPase activating protein whose mutations cause X-linked

300 movement, and association of Cdc42-directed GTPase-Activating Proteins with secretory vesicles incre