ライフサイエンスコーパス: H-bond

1 the metal (via heterolytic cleavage of an M-H bond).

2 pable of direct insertion into an aromatic C-H bond.

3 th appear to operate through scission of a C-H bond.

4 y rate-determining elimination of the beta-C-H bond.

5 elative to activation of a beta-amino C(sp3)-H bond.

6 e insertion of an ester or amide into the Cu-H bond.

7 ition metal followed by insertion into the C-H bond.

8 active sites achieve activation of strong C-H bonds.

9 taining alkyl, allyl, benzyl and propargyl C-H bonds.

10 m transfer likely predominate for stronger C-H bonds.

11 tioenriched amine precursors from abundant C-H bonds.

12 described as strong oxidants that activate C-H bonds.

13 orporate fluoride ions directly into alkyl C-H bonds.

14 ich enables the C3-selective borylation of C-H bonds.

15 selectively cleaves sterically unhindered C-H bonds.

16 lex (1) that is highly reactive with sp(3) C-H bonds.

17 rameters to differentiate between multiple C-H bonds.

18 pient of electrons released upon breaking Fe-H bonds.

19 s here include C(sp)-H, C(sp2)-H, and C(sp3)-H bonds.

20 benzylic, allylic, and propargylic C(sp(3) )-H bonds.

21 t inability to measure processes involving C-H bonds.

22 or blocked, borylation of strong secondary C-H bonds.

23 llography and capable of activating strong C-H bonds.

24 atom bonds by directly engaging ubiquitous C-H bonds.

25 e the silylation of aromatic and aliphatic C-H bonds.

26 ted via amination of C(sp(3))-H and C(sp(2))-H bonds.

27 f the iridium-catalyzed silylation of aryl C-H bonds.

28 substrates featuring multiple activatable C-H bonds.

29 steric effect, including pai-conjugation and H-bonding.

30 Y is significantly reduced in networks with H-bonding.

31 cular structure stabilized by intermolecular H-bonding.

32 like 2-butanol oligomers and promote dimeric H-bonded 2-butanol networks.

33 tic C(sp(2))-H bonds over aliphatic C(sp(3))-H bonds(4).

34 Selective N-methylation of the H-bond accepting nitrogen ablates inhibitor potency, con

35 es reveal that the imidazole core acts as an H-bond acceptor for the catalytic lysine (K745) in the "

36 D-type complexes with suitable complementary H-bonding acceptor partners.

37 onds of other reagents, as well as O-H and C-H bonds, across unactivated internal alkenes to streamli

38 intermediates that underwent Pd-catalyzed C-H bond activation and allylic oxidation.

39 zymes highlights their ability to catalyze C-H bond activation and functionalization, in many cases,

40 nters bearing nitriles by cobalt-catalyzed C-H bond activation and sequential addition to internally

41 Reversible heterolytic N-H and H-H bond activation by MLC is shown, in which hemilability

42 re mutants indicate that the efficiency of C-H bond activation directly correlates with the Mn/Fe cof

43 for the 5'-dAdo* that can allow selective X-H bond activation in both radical SAM and adenosylcobala

44 rom the experimental outcome, showing that C-H bond activation is irreversible and not the rate-deter

45 2-arylpyridines with aryl isocyanates via C-H bond activation is less efficient than described previ

46 nal investigations suggest that the C(sp(3))-H bond activation is the rate-limiting step for both the

47 The process utilizes C-H bond activation methods to explore chemical space by t

48 nverse sandwich imide complex arising from C-H bond activation of toluene, [{((Me(3)Si)(2)N)(2)U(THF)

49 ler activation barrier than 1 to carry out C-H bond activation reactions.

50 The potential of this ortho-C-H bond activation strategy has also been exploited towar

51 ology for preparing dibenzosuberones via a C-H bond activation strategy is presented.

52 The complex underwent intermolecular C-H bond activation upon thermolysis and exhibited hydroal

53 cyclotrimerization, C-O bond cleavage, and C-H bond activation, are triggered on demand, leading to p

54 he Suzuki-Miyaura cross-coupling reaction, C-H bond activation, dehydrogenative coupling, Huisgen 1,3

55 ation of benzylamines and nitriles via C-H/N-H bond activation, providing straightforward atom-econom

56 d sigma-bond metathesis pathway for C(sp(2))-H bond activation, which is further discussed in this st

57 ection to our fundamental understanding of C-H bond activation.

58 reactivity of molecular U(III) nitrides in C-H bond activation.

59 e.g., petroleum) by inert carbon-hydrogen (C-H) bond activation using classical chemical methods (i.e

60 ngle operation through a cascade of triple C-H bond activations is the beauty of this protocol.

61 selective functionalization of the C(sp(3))-H bond adjacent to the pyridine ring of pharmacologicall

62 ctively functionalize benzylic and allylic C-H bonds, affording a broad scope of enantioenriched prim

63 Attempts to borylate the C-H bond alpha to a benzylic ether or amine resulted in C-

64 s alkyl carboxylic acids, benzylic C(sp(3) )-H bonds also could be functionalized to form 3,4-dihydro

65 ridine) displays productive intramolecular C-H bond amination to afford N-heterocyclic products using

66 s to utilize the distance between a target C-H bond and a coordinating functional group, along with t

67 nable fluorination of allylic and benzylic C-H bonds and alpha-C-H bonds of ethers at room temperatur

68 ps is needed, particularly for cleavage of N-H bonds and formation of N-N bonds.

69 carbamate esters bearing gamma-propargylic C-H bonds and furnishes versatile products in good yields

70 of U(III), which is highly reactive toward C-H bonds and H(2).

71 i-GMP dimer is tightly bound by a network of H bonds and pai-stacking interactions involving arginine

72 reagent, undirected borylation of primary C-H bonds and, when primary C-H bonds are absent or blocke

73 These data show that H-bonding and electrostatic interactions of the base wit

74 These results show that H-bonding and electrostatic interactions taking place in

75 e self-assembly in water by a combination of H-bonding and hydrophobicity and to impart specific resp

76 verall binding by both creating strong ionic H-bonds and changing the secondary H-bonds from unfavora

77 UDP-GlcUA, whereby the side chain of Arg259 H-bonds and forms a salt bridge with the carboxylate gro

78 r-protic solvent combinations to disrupt the H-bonds and hydrophobic interactions holding together th

79 Experimentally, studies confirmed that H-bonds and LA(II) s can interact directly with the oxid

80 valent interactions, such as hydrogen bonds (H-bonds) and electrostatic interactions; however, there

81 ic center on the TDG is often far from the C-H bond, and both TDG covalently attached to the substrat

82 a variety of ethers, alkanes, unactivated C-H bonds, and alcohols.

83 cluding Watson-Crick base pairing, Hoogsteen H-bonding, and pai-pai stacking, resulting in unusual su

84 by its sensitivity to the protonation state, H-bonding, and the conformation of different groups in p

85 eptide interactions, including salt bridges, H-bonds, and polar interactions.

86 ion of primary C-H bonds and, when primary C-H bonds are absent or blocked, borylation of strong seco

87 Site-selective functionalizations of C-H bonds are often achieved with a directing group that l

88 These weak C-H bonds are shown to undergo proton-coupled electron tra

89 benzylic, tertiary, secondary, and primary C-H bonds are successfully aminated.

90 Traditional H bonds are ubiquitous in nature, yet the demonstration

91 to the stereospecific functionalization of C-H bonds, are employed to generate structural diversity.

92 Applications to the C-H bond arylation of bipyridine ligands is also presented

93 loped as efficient precatalysts for direct C-H bond arylation of various heteroarenes.

94 m shows that Ni does not cleave the C(sp(3))-H bonds as previously proposed; rather, it catalyzes the

95 g multiple functionalities from ubiquitous C-H bonds, as showcased with stereoselective construction

96 functionalization, discrete activation of C-H bonds at Ni(I) complexes has rarely been described.

97 g palladium-catalyzed oxidation of primary C-H bonds beta to nitrogen in an imine of an aliphatic ami

98 amic reflecting a weakening and restoring of H bonds between bound water and the secondary OH of beta

99 copy experiments that reveal the presence of H bonds between the chloroform C-H group and an amide ca

100 We have also identified an important H-bond between residues T176 and Y226 that is critical t

101 A proposed internal H-bond between the amine and neighboring benzenesulfonam

102 Activation and borylation of N-H bonds by [Ni(IMes)(2)] is essential to install a Bpin

103 the enantioselective functionalizations of C-H bonds by chiral iridium complexes with emphasis on the

104 of Ni-catalyzed oxidations of unactivated C-H bonds by mCPBA.

105 proposed to effect the cleavage of strong C-H bonds by nonheme diiron enzymes such as soluble methan

106 on transfer induced proton transfer across a H-bond can be used to significantly strengthen the overa

107 Chemical functionalities (e.g. H-bonding) can be easily included to modulate the transp

108 particular, the detection of protonation and H-bonding changes in a time-resolved manner, not easily

109 lly relied on precious-metal catalysts for C-H bond cleavage and, as a result, display high selectivi

110 rylative cyclization of enynes involving a C-H bond cleavage is reported.

111 ts, which indicated that the gamma-C(sp(3) )-H bond cleavage is the rate-limiting step during the rea

112 ed suggest that the initial allenic C(sp(3))-H bond cleavage is the rate-limiting step, which was sup

113 led a KIE of 3 that can be assigned to the C-H bond cleavage step during formate oxidation.

114 ns are typically required to enable C(sp(3))-H bond cleavage, barring potential applications in synth

115 ial allene attack involving allenic C(sp(3))-H bond cleavage, but it also induces a face-selective re

116 In this work, we demonstrated that the C-H bond cleaving reactivity of 1 can be further enhanced

117 nstants and the ability to cleave stronger C-H bonds compared to 1.

118 Their ability to form H-bonded complexes has never been touched so far.

119 focus, however, has been mostly reserved for H-bonds comprising a single donor and a single acceptor.

120 e potentially due to the pre-organization of H-bonding containing monomer during network curing.

121 osed to separate the direct (solute-network) H-bonding contribution to solute diffusion from the indi

122 udies of peripherally NBN-doped PAHs to form H-bonded DD.AA- and ADDA.DAAD-type complexes with suitab

123 ing constants of the two competing allylic C-H bonds (Delta(1)J(CH)) and the C-H activation barriers

124 w strategy to create highly redox-responsive H-bond dimers based on proton-coupled electron transfer

125 The latter value is typical of DDD-AAA H-bond dimers, consistent with proton transfer across th

126 s in determining overall binding strength in H-bond dimers.

127 d A units and a structure-directing unit for H-bond-directed supramolecular self-assembly.

128 ms a well-ordered 10/12-helix with alternate H-bond directionality in spite of the smallest value of

129 By introducing the H-bonding disrupter, LiClO(4), it was found that the dif

130 e permeability which is similarly subject to H-bond disruption.

131 ation states toward substrates with modest O-H bond dissociation energies (e.g., 4-substitued-2,6-di-

132 easured reduction potential and pK(a), the O-H bond dissociation free energy (BDFE) of hydroperoxide

133 with MeOH competitively displacing PBAT from H-bond donating sites on mineral surfaces.

134 ntiodetermining delivery of bromide from the H-bond-donor (HBD) catalyst to the activated oxetane.

135 sic spatial scale, we investigated ultrafast H-bond dynamics between water and biomimetic self-assemb

136 nature and meso- and microscopic ordering of H-bond dynamics could contribute to the flexibility and

137 the net insertion of the nitride into the E-H bonds (E=B, Si).

138 edly different dynamics, suggesting distinct H-bond environments, despite being separated by only a f

139 ion of less activated allylic and benzylic C-H bonds even in the presence of electronically preferred

140 rium oxidative addition of the amine alpha-C-H bond followed by rate-determining elimination of the b

141 may occur via substrate insertion into the M-H bond, followed by P-C reductive elimination, or by ins

142 tive functionalization of racemic tertiary C-H bonds for stereoselective construction of chiral molec

143 termolecular diarylcarbene insertion into Si-H bonds for the synthesis of silicon-stereogenic silanes

144 vation, isobutene elimination, and C-C and P-H bond formation bicyclic 1-benzo-dihydrophosphetes (2)

145 witching between homolytic and heterolytic H-H bond formation pathways through molecular engineering,

146 rane helices have at least one non-canonical H-bond formed by a serine or threonine residue whose hyd

147 Several H-H bond forming pathways have been proposed for the hydro

148 ong ionic H-bonds and changing the secondary H-bonds from unfavorable to favorable.

149 This C-H bond functionalization and spirocyclization showed wid

150 study underlines the development of C(sp(3))-H bond functionalization chemistry that should find wide

151 Here we report an advance in C-H bond functionalization methodology that enables the in

152 s for the practical application of C(sp(3) )-H bond functionalization methods.

153 A room-temperature C-H bond functionalization of benzamides has been develope

154 plify access to such materials through the C-H bond functionalization of feedstock alicyclic amines,

155 in the field, methods for the direct alpha-C-H bond functionalization of unprotected alicyclic amines

156 hown their large potential in the field of C-H bond functionalization reactions.

157 e iridium-catalysed borylation of aromatic C-H bonds has become the preferred method for the synthesi

158 double functionalization of vicinal sp(3) C-H bonds has been developed, wherein a beta amine and gam

159 The ability to oxidize strong C-H bonds has yet to be observed for Co(IV)-O and Co(III)=

160 nisms by which they react to functionalize C-H bonds have been reported.

161 steric effects, such as the borylation of C-H bonds, have been poor in many cases.

162 The related C-H bonds here include C(sp)-H, C(sp2)-H, and C(sp3)-H bon

163 lectron transfer (MS-CPET) activation of a C-H bond in a proof-of-concept fluorenyl-benzoate substrat

164 inference that hole-driven scission of the O-H bond in H(2) O is a critical, limiting step in plasmon

165 key in assisting the cleavage of the meta-C-H bond in the concerted metalation-deprotonation (CMD) p

166 oduces a covalent modification at a C(sp(3))-H bond in the methyl group of N6-methyl deoxyadenosine a

167 ty to differentiate between highly similar C-H bonds in a given molecule remains a fundamental challe

168 regioselective halogenation of unactivated C-H bonds in bacteria, they remain uncharacterized in the

169 The selective replacement of C-H bonds in complex molecules, especially natural product

170 zoyloxy radical derived from mCPBA cleaves C-H bonds in the alkane to form an alkyl radical, which su

171 Activation of aliphatic C(sp(3))-H bonds in the presence of more activated benzylic C(sp(

172 f strong, typically inert carbon-hydrogen (C-H) bonds in organic molecules is changing synthetic chem

173 tor potency, confirming the role of the K745 H-bond in potent, noncovalent inhibition of the C797S va

174 ddressed, and work towards the deployment of H-bonding in water has accelerated.

175 t capitalizes on the importance of secondary H-bonds in determining overall binding strength in H-bon

176 (n) by modulating the strength and number of H-bonds in the system.

177 ed to the electronic properties of allylic C-H bonds indicated by the corresponding (1)J(CH) coupling

178 acceptors (-F, -Cl, -Br, -OR) establish the H-bonding interaction strength for the -CF(2)H group (~3

179 he number of OH functions and their inherent H bonding interactions, but also the wide range of polyo

180 To gain insight into H-bond interactions at the materials' intrinsic spatial

181 uoroacetamide derivative engages in extended H-bond interactions in its crystal structure.

182 e separate intramolecular and intermolecular H-bond interactions.

183 of the mu-OH(-) ligands and the presence of H-bonding interactions between the mu-OH(-) bridging lig

184 r pocket" stitches the gelators through weak H-bonding interactions to facilitate the formation of an

185 1,10-phenanthroline provides highly directed H-bonding interactions with Pd-coordinated substrates.

186 consistent with pK(a) tuning by one or more H-bonding interactions.

187 eometries influenced by torsional strain and H-bonding interactions.

188 activation' strategies that convert inert C-H bonds into C-metal bonds prior to C-C bond formation.

189 en-bonded silver complex in which a single C-H bond is exposed to the catalytic reaction center.

190 in up to 98% yield and up to 98% ee if the C-H bond is in a benzylic position.

191 ected C-H functionalization, even when the C-H bond is intrinsically reactive.

192 mental studies showed that cleavage of the C-H bond is rate-limiting and formation of the strained fo

193 ond activation for substrates in which the C-H bond is weak, while stepwise carboxylate oxidation and

194 e of strong C-O bonds without breaking C-C/C-H bonds is a key step for catalytic conversion of renewa

195 activated primary, secondary, and tertiary C-H bonds is discovered.

196 The selective hydroxylation of C-H bonds is of great interest to the synthetic community.

197 presence of more activated benzylic C(sp(3))-H bonds is often a nontrivial, if not impossible task.

198 The selective functionalization of C-H bonds is one of the Grails of synthetic chemistry.

199 t competing functionalization of secondary C-H bonds is rare.

200 a bulky singly protonated cation that avoids H-bonding is ideal.

201 H-bonding is the predominant geometrical determinant of

202 termediates formed from native sulfonamide N-H bonds leading to 1,4-cyclohexadiene-fused sultams.

203 n the presence of electronically preferred C-H bonds located alpha to oxygen.

204 steric and electronic differences between C-H bonds located distal to functional groups has prevente

205 The reduced number of H-bonds maintained by the dynamic dark chromophore in gr

206 It starts by reviewing how changes in H-bonding, medium polarity, and vibrational coupling aff

207 e amplitudes and/or timescales of backbone N-H bond motions, corresponding to a rigidification of the

208 The H-bond network between the components of each DES was ev

209 With the improved H-bonding network and structural motions, the photoexcit

210 ular dynamics is dominated by either complex H-bonded networks most probably leading to supramolecula

211 mperatures, transient tetrahedral domains of H-bonding networks are evidenced and the observation of

212 ylation and alkylation of alpha-amino C(sp3)-H bonds occurs via the sequence of nickel oxidation stat

213 istic study shows that the cleavage of the C-H bond of alcohol is the rate-determining step.

214 amples occur by the direct addition of the N-H bond of amines across unactivated internal alkenes(5-7

215 oamination of alkenes, the addition of the N-H bond of an amine across an alkene, is a fundamental, y

216 l C atom of the P=C=C group into the alpha-C-H bond of an iPr substituent and by C-C and P-C bond for

217 al-oxo sites and subsequently activate the C-H bond of methane.

218 cient catalytic method to convert an alpha-C-H bond of N-alkylamines into an alpha-C-alkynyl bond was

219 Complexes 2-4 activate a C-H bond of symmetrically and asymmetrically substituted a

220 Insertion of sulfur into the B-H bond of the BH borenium salt [IMes(C(6)F(5))BH](+) fol

221 reactive and undergoes 1,2-addition of the C-H bond of the N(SiMe(3))(2) ligand across the uranium-ni

222 the nickel catalyst to activate the ortho-C-H bond of the phenyl ring of the benzylamine.

223 ated that activation of a alpha-amino C(sp3)-H bond of the substrate is facile and selective relative

224 propylphosphino)xanthene) coordinates the Si-H bond of triethylsilane, 1,1,1,3,5,5,5-heptamethyltrisi

225 Furthermore, 2-trans oxidizes the aromatic C-H bonds of 2,6-di-tert-butylphenol, which, together with

226 direct monoarylation of unactivated C(sp(3))-H bonds of 8-methyl quinolines with arylboronic acids to

227 Functionalization of the beta-C-H bonds of aliphatic acids is emerging as a valuable syn

228 energy storage and retrieval based on the N-H bonds of ammonia in a carbon-free energy cycle.

229 iscrimination between the two enantiotopic C-H bonds of an unactivated methylenic group is particular

230 symmetrical functionalization of both o,o'-C-H bonds of arene moiety is explicitly viable under the i

231 f this method for controlled grafting from C-H bonds of commodity polymers.

232 f allylic and benzylic C-H bonds and alpha-C-H bonds of ethers at room temperature.

233 MMO-Q necessary to attack the highly inert C-H bonds of methane.

234 rinciples point the way to the addition of N-H bonds of other reagents, as well as O-H and C-H bonds,

235 r functionalization of the alpha-methylene C-H bonds of these highly privileged building blocks is of

236 lization at the most sterically accessible C-H bonds of these rings under conditions that the borylat

237 actions at one of the two carbon-hydrogen (C-H) bonds of a methylene group, tertiary stereocentres co

238 In this context, distinguishing remote C-H bonds on adjacent carbon atoms is an extraordinary cha

239 volving the intramolecular coupling of two C-H bonds on gem-dialkyl groups has remained an elusive tr

240 ectivity for borylation of aromatic C(sp(2))-H bonds over aliphatic C(sp(3))-H bonds(4).

241 y oxidants in many enzymatic and synthetic C-H bond oxidation reactions.

242 Hydrogen bonds (H bonds) play a major role in defining the structure and

243 The evolved enzyme leaves C-H bonds present in the silane substrates untouched, and

244 ilities to design novel materials, where the H-bonding properties of peripheral NH hydrogens could se

245 site-selective functionalization of C(sp(3))-H bonds provides the basis for efficient three-dimension

246 ansformation of a traditionally unreactive C-H bond, proximal to the nitrogen atom, into a versatile

247 posed to facilitate the oxidation of inert C-H bonds, reactions that are unknown for histidine-ligate

248 hods for the trifluoromethylation of alkyl C-H bonds remain elusive.

249 tly install a free amine group into C(sp(3))-H bonds remain unprecedented.

250 he ubiquitous and often chemically similar C-H bonds remains a significant challenge.

251 h materials, but the role of hydrogen bonds (H bonds) remains unclear.

252 ive functionalizations of carbon-hydrogen (C-H) bonds represent a promising pathway toward this goal.

253 polymerization selectively grafting from a C-H bond represents a powerful strategy for polymer conjug

254 0)xxxS(44)xxxG(48)) together with a patch of H-bonding residues (T(51), T(54), N(55)) sideways along

255 -linked thioether bond is accompanied by a C-H bond scission on Tyr272 with few details known thus fa

256 We propose that these strong H-bonds serve to stabilize serine and threonine residues

257 All compounds devoid of B-H bonds show favorable optoelectronic properties, such a

258 The ordered H-bonding solvent network present in hydrophobic Sn-Beta

259 lizes multiple noncovalent interactions like H-bonding, solvent bonding, S-H...pai, C-H...pai, pai-pa

260 to microscopic diffusivity, arising from the H-bond strength of the co-monomers, also contribute sign

261 ries of polyacrylate networks with differing H-bonding strength were undertaken; it was found that th

262 Distal H-bonding substitutions of the N(6)-(2-phenylethyl) moie

263 The scope of C-H bond substrates was explored and benzylic, tertiary, s

264 activate a previously inaccessible remote C-H bond that is one bond further away.

265 ssential to develop strategies to activate C-H bonds that are distal from a functional group.

266 ous in nature, yet the demonstration of weak H bonds that occur between a highly polarized C-H group

267 etrahydrofuran for substrates with O-H and N-H bonds that undergo 1e(-)/1H(+) and 2e(-)/2H(+) redox p

268 e the prevalence and energetics of multiplex H-bonds that are formed between three or more groups.

269 These proteins contain a continuous chain of H-bonds that impart stability, causing difficulty in dig

270 by direct homolytic activation of alcohol O-H bonds through a proton-coupled electron-transfer mecha

271 vdW interactions do not allow H(2)O-diester H-bonding, thus forcing nBA side groups to adapt L-shape

272 veraging the reactivity of benzylic C(sp(3))-H bonds to achieve reactivity at the homobenzylic positi

273 )J(NH...F(-)) give insight into how multiple H bonds to fluoride influence reaction performance.

274 9) as the major module engaging gamma8 by an H-bond to Asn-172 (gamma8).

275 ionization of the nucleophilic l-Tyr37, now H-bonded to l-Lys47, resulting from repositioning of l-L

276 threonine residue whose hydroxyl side chain H-bonds to an over-coordinated carbonyl oxygen at positi

277 he fluorination and chlorination of remote C-H bonds under exceptionally mild conditions with exceedi

278 tandem oxidation and cyclization of sp(3) C-H bonds under metal-free conditions.

279 tal catalysis for the functionalization of C-H bonds under mild conditions.

280 ermal stability, 2 is able to cleave sp(3) C-H bonds up to 87 kcal/mol to afford rate constants and k

281 tent with proton transfer across the central H-bond upon reduction.

282 polymerization selectively from a hydridic C-H bond using a benzophenone photocatalyst, a trithiocarb

283 inducing C-H functionalization at tertiary C-H bonds versus their triaryl counterparts but are genera

284 s was found to facilitate the formation of N-H bonds via proton-coupled electron transfer to generate

285 This report presents the oxygenation of C-H bonds via the merger of photocatalysis and Pd catalysi

286 H-bonding was controlled by exposure to solvent vapor (s

287 ontain up to eight discrete alpha-ethereal C-H bonds, we observed site-selectivity in each case, prom

288 00 turnovers for the oxidation of benzylic C-H bonds were obtained.

289 , including the functionalization of inert C-H bonds, which is a major challenge for chemists.

290 Site-selective functionalization of C-H bonds will ultimately afford chemists transformative t

291 lysed oxidative cross coupling of benzylic C-H bonds with alcohols to afford benzyl ethers, enabled b

292 or copper-promoted chalcogenation of sp(2) C-H bonds with aryl and alkyl disulfides as well as diphen

293 yze the direct primary amination of C(sp(3))-H bonds with excellent chemo-, regio-, and enantioselect

294 t showcases high chemoselectivity favoring C-H bonds with lower bond dissociation energy as well as a

295 gs under conditions that the borylation of C-H bonds with previously reported catalysts formed mixtur

296 ndole congeners was found to form a stronger H-bond with Leu300 of AR and to render larger rotational

297 repair was the ability of the A analogues to H-bond with the Hoogsteen face of OG.

298 fluoride, within 3, occurs through NH...F(-) H-bonding with the six NH residues of the tris-urea liga

299 structural features, such as steric fit and H-bonding within the active site for proper alignment wi

300 he undirected functionalization of primary C-H bonds without competing functionalization of secondary