ライフサイエンスコーパス: H1N1 influenza virus

1 hospitalized transplant recipients with 2009 H1N1 influenza virus.

2 ed into recombinant A/Puerto Rico/8/34 (PR8) H1N1 influenza virus.

3 than did pigs infected with wild-type human H1N1 influenza virus.

4 terpene with remarkable activity against the H1N1 influenza virus.

5 ral lung titers, following challenge with an H1N1 influenza virus.

6 IV (mean of 64 days), were challenged with A/H1N1 influenza virus.

7 tein 1, and polymerase basic protein 1 of an H1N1 influenza virus.

8 ate 100% survival from lethal challenge with H1N1 influenza virus.

9 ram) anti-influenza antibodies binding to an H1N1 influenza virus.

10 ere introduced into the genome of a seasonal H1N1 influenza virus.

11 e from a lethal challenge with 2009 pandemic H1N1 influenza virus.

12 ses and protective efficacy against pandemic H1N1 influenza virus.

13 he first reported cases of the pandemic 2009/H1N1 influenza virus.

14 cing infection with high viral loads of 2009 H1N1 influenza virus.

15 iruses and to specifically identify the 2009 H1N1 influenza virus.

16 oss-protection against the swine-origin 2009 H1N1 influenza virus.

17 otect against the pandemic swine-origin 2009 H1N1 influenza virus.

18 nt recipients; 4 were confirmed to have 2009 H1N1 influenza virus.

19 Testing was with nebulized A/PR/8/34 (H1N1) influenza virus.

20 inhibition (HAI) activity against a panel of H1N1 influenza viruses.

21 f historical seasonal-like and pandemic-like H1N1 influenza viruses.

22 cted with either 1918 or 2009 human pandemic H1N1 influenza viruses.

23 ing a potent neutralization activity against H1N1 influenza viruses.

24 ss2, in knockout mice inhibits the spread of H1N1 influenza viruses.

25 nt as therapeutic agents against circulating H1N1 influenza viruses.

26 infection with two pandemic and two seasonal H1N1 influenza viruses.

27 tion H274Y in the neuraminidase (NA) gene of H1N1 influenza viruses.

28 ough the host was never exposed to the novel H1N1 influenza viruses.

29 urred in the HA of naturally occurring human H1N1 influenza viruses.

30 e from lethal challenges with either H5N1 or H1N1 influenza viruses.

31 resulted in a decrease in the replication of H1N1 influenza viruses.

32 by a virus very similar to present swine (A/H1N1) influenza viruses.

33 o confer protection against a lethal dose of H1N1 influenza virus A/Puerto Rico 8/34 (PR8).

34 04 (VN1203), and the NA of the mouse-adapted H1N1 influenza virus A/Puerto Rico/8/34 (PR8) in the VSV

35 of cell death is a distinguishing feature of H1N1 influenza virus A/Puerto Rico/8/34 protein PB1-F2.

36 s were protected from challenge with a novel H1N1 influenza virus (A/California/07/2009), and these f

37 r M-Tri-DAP and subsequently challenged with H1N1 influenza virus (A/England/195/2009).

38 vector encoding the hemagglutinin (HA) of an H1N1 influenza virus (A/Swine/Indiana/1726/88) to porcin

39 structure in complex with HA from a pandemic H1N1 influenza virus, A/South Carolina/1/1918(H1N1), rev

40 eplaced with genes from a contemporary human H1N1 influenza virus, A/Texas/36/91 (Tx/91), were genera

41 nversion, ferrets were challenged with novel H1N1 influenza virus and assessed for viral titers in th

42 omolgus macaques with highly pathogenic 1918 H1N1 influenza virus and assessed pathogenesis and disea

43 ted to understand better the pathogenesis of H1N1 influenza virus and associated host mucosal immune

44 with escalating concerns regarding the novel H1N1 influenza virus and its recently approved vaccine,

45 mechanism underlying broad immunity against H1N1 influenza viruses and identifies a conserved epitop

46 , Muc5ac-Tg animals were challenged with PR8/H1N1 influenza viruses and showed significant decreases

47 Exposure to multiple seasonal H1N1 influenza viruses, and not to any single H1N1 influ

48 natural history and transmission of the 2009 H1N1 influenza virus appear to be similar to those of pr

49 In early 2009, a novel pandemic H1N1 influenza virus appeared, but it has not exhibited

50 H1N1 influenza viruses are responsible for both seasonal

51 ferrets with antigenically distinct seasonal H1N1 influenza viruses boosts the antibody responses dir

52 However, oseltamivir-resistant H1N1 influenza viruses carrying the H275Y NA mutation sp

53 Oseltamivir-resistant H1N1 influenza viruses carrying the H275Y neuraminidase

54 An H1N1 influenza virus caused a pandemic in 2009, and desc

55 ast to seasonal influenza H1N1 virus, 2009 A(H1N1) influenza viruses caused increased morbidity, repl

56 ce from homologous and heterologous H3N2 and H1N1 influenza virus challenge.

57 100% in vivo protection efficacy against the H1N1 influenza virus challenge.

58 ity and improved protection against the 2009 H1N1 influenza virus, compared with subcutaneous injecti

59 e, the X-181 strain of the 2009 new pandemic H1N1 influenza virus, derived from the A/California/07/2

60 e hemagglutinin and nucleoprotein genes from H1N1 influenza virus developed serum anti-H1 immunoglobu

61 nstrate that memory CD4 T cells specific for H1N1 influenza virus directed protective responses to in

62 reover, sequential infection of ferrets with H1N1 influenza viruses elicited an Igkappa-biased Ab res

63 expressing NA from avian (H5N1) or pandemic (H1N1) influenza virus, elicited NA-specific antibody and

64 1N1 influenza viruses, and not to any single H1N1 influenza virus, elicits a breadth of antibodies th

65 A novel H1N1 influenza virus emerged in 2009 (pH1N1) to become t

66 In 2009, a novel H1N1 influenza virus emerged in humans, causing a global

67 The rapid dissemination of the 2009 pandemic H1N1 influenza virus emphasizes the need for universal i

68 Here, we used an H1N1 influenza virus encoding a fluorescent reporter gen

69 is report, we show that recombinant H5N1 and H1N1 influenza viruses encoding a truncated NS1 protein

70 evidence supporting the hypothesis that the H1N1 influenza virus entered the human population just p

71 The 2009 A(H1N1) influenza viruses exhibited less efficient respira

72 Primary infection with s-H1N1 influenza virus followed by a dose of p-LAIV result

73 een preferentially eliminated from classical H1N1 influenza virus genomes during virus evolution in h

74 all challenge viruses, including a relevant H1N1 influenza virus group 1 strain, with minimal weight

75 , the avian-derived PB2 of the 2009 pandemic H1N1 influenza virus has 271A.

76 The emergence of the pandemic 2009 H1N1 influenza virus has become a world-wide health conc

77 Swine origin 2009 H1N1 influenza virus has spread globally to cause the fi

78 es that elicit protective antibodies against H1N1 influenza viruses have been developed.

79 Drug-resistant H1N1 influenza viruses have dominated the 2009 flu seaso

80 Thus, our data show that 2009 H1N1 influenza viruses have evolved after pandemic onset

81 re is increasing evidence that 2009 pandemic H1N1 influenza viruses have evolved after pandemic onset

82 tration was associated with lower odds for A/H1N1 influenza virus illness, indicating its potential a

83 tration was associated with lower odds for A/H1N1 influenza virus illness, indicating its potential a

84 fection with pandemic-like and seasonal-like H1N1 influenza viruses.IMPORTANCE There is a great need

85 g the emergence and global spread of a novel H1N1 influenza virus in 2009, two A(H1N1)pdm/09 influenz

86 en associated with the 2009-2010 pandemic of H1N1 influenza virus in China and with mass vaccination

87 The transmissibility of the 2009 H1N1 influenza virus in households is lower than that se

88 ve relevance to pathogenesis of the pandemic H1N1 influenza virus in humans; thus, pigs may serve as

89 ne from an H5N1 virus rescued replication of H1N1 influenza virus in macrophages.

90 h displayed an EC50 value of 2.1 muM against H1N1 influenza virus in MDCK cells.

91 We show that infection with H1N1 influenza virus in mice that lack B and T cells (Re

92 The spread of the 2009 H1N1 influenza virus in the population worldwide, in add

93 We show that pandemic H1N1 influenza virus in which the hemagglutinin signal s

94 essential for the spread and pathogenesis of H1N1 influenza viruses in mice.

95 mmalian (swine H1N1, human H1N1 and pandemic H1N1) influenza viruses in PAM.

96 hile the seroprevalence of seasonal H3N2 and H1N1 influenza viruses increased with the decline of amb

97 Accordingly, SARS-CoV-2, but not H1N1 influenza virus, increases levels of brain IL-1beta

98 kines were also seen in either SARS-CoV-2 or H1N1 influenza virus-infected mice, which were treated a

99 ibution and severity of pneumonia after 2009 H1N1 influenza virus infection in newly weaned, adult, a

100 The estimated rate of admission for pandemic H1N1 influenza virus infection in pregnant women during

101 dation to promptly treat pregnant women with H1N1 influenza virus infection with anti-influenza drugs

102 nstrated lung regeneration in mice following H1N1 influenza virus infection, and linked distal airway

103 lated form as new therapeutic agents against H1N1 influenza virus infection.

104 protects ferrets against aerosol-transmitted H1N1 influenza virus infection.

105 st TLR-triggered immune response and cleared H1N1 influenza virus infection.

106 revention of disease and control of pandemic H1N1 influenza virus infection.

107 ) to mediate protection against swine-origin H1N1 influenza virus infection.

108 A remarkable feature of the 2009 pandemic H1N1 influenza virus is its efficient transmissibility i

109 ily accelerated clearance of a 2009 pandemic H1N1 influenza virus isolate in an antibody-dependent ma

110 based vaccine for both seasonal and pandemic H1N1 influenza virus isolates.

111 The 2009 H1N1 influenza virus outbreak is the first pandemic of t

112 ith heterologous strains, including the 2009 H1N1 influenza virus pandemic strain.

113 The 1918 H1N1 influenza virus pandemic was the most severe of the

114 omestic pigs infected with the 2009 pandemic H1N1 influenza virus (pH1N1) have been detected worldwid

115 death from infection with the 2009 pandemic H1N1 influenza virus (pH1N1).

116 ss-species transmission of the 2009 pandemic H1N1 influenza virus (pH1N1).

117 Preexisting immunity to the 2009 pandemic H1N1 influenza virus prevented severe H5N1 disease and r

118 Subsequent human infections with novel H1N1 influenza viruses prompted an investigation of the

119 eal that first exposure to the 2009 pandemic H1N1 influenza virus recalls memory B cells that are spe

120 damage and high lethality caused by the 1918 H1N1 influenza virus remains largely unknown.

121 regulated in the lungs of patients with 2009 H1N1 influenza virus, respiratory syncytial virus, or pa

122 major concern about the ongoing swine-origin H1N1 influenza virus (S-OIV) outbreak is that the virus

123 to elicit antibody responses that neutralize H1N1 influenza viruses spanning over 90 years.

124 luenza A and B viruses, including a pandemic H1N1 influenza virus strain, a highly pathogenic H5N1 av

125 ed to the disappearance of existing seasonal H1N1 influenza virus strains.

126 Pigs infected with recombinant human H1N1 influenza virus that carried the H5N1 NS gene exper

127 we determined the ability of representative H1N1 influenza viruses that circulated in the human popu

128 h seasonal H1N1 and triple-reassortant swine H1N1 influenza viruses that have circulated among North

129 For H1N1 influenza viruses, the mouse-adapted A/WSN/33 strai

130 humans caused by a novel swine-origin 2009 A(H1N1) influenza virus underscore the need to better unde

131 The 2009 H1N1 influenza virus was first identified in April 2009

132 ted with highly pathogenic H5N1 and seasonal H1N1 influenza viruses was evaluated using mass spectrom

133 Transmission of the 2009 A(H1N1) influenza viruses was further corroborated by char

134 H1N1 influenza viruses were responsible for the 1918 pan

135 ortment between H3N2 human and classic swine H1N1 influenza viruses, while the others arose from reas

136 t and infectious HIV, hepatitis C virus, and H1N1 influenza virus, whole-genome gene expression analy

137 in ferrets infected with any single seasonal H1N1 influenza viruses, with limited protection to chall

138 oled and tested for the presence of the 2009 H1N1 influenza virus without a reduction in sensitivity.