ライフサイエンスコーパス: HAC

1 HAC and RS patients had higher maximum standardized upta

2 HAC are important vectors for investigating the organiza

3 HAC have so far been obtained in immortalized or tumour-

4 HAC with body weight <35 kg had lower peak FVIII:C, high

5 HAC-seq provides a novel method for the unbiased, transc

6 HACs avoid the limited cloning capacity, lack of copy nu

7 HACs have been used to complement gene deficiencies in h

8 II-4 cells at ratios of 4:1, 12:1, and 50:1 (HAC:II-4) when compared with coculture with normal human

9 Like mammalian APAF-1, HAC-1 can activate caspases in a dATP-dependent manner i

10 ere histologically classified as: 95 RS, 117 HAC, and 120 histologically indolent CLL (HIC).

11 The 17alpha HAC vectors generated artificial minichromosomes in 32-7

12 The 17alpha HAC vectors produced megabase-sized, circular HACs conta

13 Camellia sinensis), (Z)-3-hexenyl acetate (3-HAC) has been characterized as associated with resistanc

14 ither one considerably impaired JA-induced 3-HAC biosynthesis in tea plant.

15 that CsCHAT1 converted (Z)-3-hexenol into 3-HAC.

16 of either one decreased the production of 3-HAC and eliminated the resistance of tea plants to E. ob

17 AT1 expression reduced the accumulation of 3-HAC and lowered the resistance of tea plants to E. obliq

18 how tea plants biosynthesize and regulate 3-HAC to resist herbivores remain unclear.

19 istance of tea plants to E. obliqua, while 3-HAC replenishment rescued the reduced resistance of CsCH

20 hogen-inoculated seedlings revealed that Z-3-HAC boosts JA-dependent defenses during the necrotrophic

21 Interestingly, analysis of the effect of Z-3-HAC pretreatment on SA- and JA-responsive gene expressio

22 scenario whereby the green leaf volatile Z-3-HAC protects wheat against Fusarium head blight by primi

23 green leaf volatile Z-3-hexenyl acetate (Z-3-HAC) primed wheat (Triticum aestivum) for enhanced defen

24 ioassays showed that, after priming with Z-3-HAC, wheat ears accumulated up to 40% fewer necrotic spi

25 clinically significant HAC (4 thromboses, 35 HACs requiring IVI) was found in 2.9% (n = 1/34), 32.1%

26 von Willebrand factor (VWF) response in 361 HACs.

27 AC carrying a gene of interest to generate a HAC vector.

28 Here, a HAC (human artificial chromosome) module with a regulate

29 conversion of any genomic BAC target into a HAC vector by transposon-mediated modification with synt

30 a, or PMA; conditioned medium from activated HAC contained all the MMPs demonstrated by immunohistoch

31 After HAC-POA implementation, the incidence of surgical site i

32 tion and control procedures before and after HAC-POA program implementation.

33 or FTOHs and FOSEs, resulting mean dust-air, HAC filter-air, dryer lint-air and particle-air partitio

34 Notably, all HAC-PD1 radiotracer variants enabled much earlier detect

35 ciation between hospital characteristics and HAC program penalization.

36 We estimate that cloth, gas phase, and HAC filters are the largest reservoirs for FTOHs, while

37 Survival of patients with RS and HAC was similar among patients with SUVmax <10 or >/=10.

38 tween the hospital quality summary score and HAC program penalization was examined.

39 ells by lipid-mediated DNA transfection, and HACs were identified that bound the active kinetochore p

40 Primary outcomes were incidence of any HAC-OP and length of stay.

41 The composite primary outcome of any HAC-OP occurred for 115 of 248 intervention participants

42 reduce the composite primary outcome of any HAC-OP or length of stay, but there was a significant re

43 We applied HAC-seq to analyze ribosomal RNA (rRNA)-depleted total R

44 ater harvesting (AWH), humidity autocontrol (HAC), heat pumps and chillers, and hydrolytic catalysis.

45 gnificantly advance the utility of BAC-based HACs for functional annotation of the genome and for app

46 III) levels in female hemophilia A carriers (HACs).

47 and function of hyaline articular cartilage (HAC) and subchondral bone (SCB), and their involvement i

48 en degradation of human articular cartilage (HAC) in vivo.

49 In addition, human articular chondrocytes (HAC) were treated in vitro with either IL-1beta, TNFalph

50 Human articular chondrocytes (HACs) and SW-1353 chondrosarcoma cells were treated with

51 a nonessential human artificial chromosome (HAC) carrying a constitutively expressed EGFP transgene.

52 goat system, a human artificial chromosome (HAC) comprising the entire human immunoglobulin (Ig) gen

53 r method uses a human artificial chromosome (HAC) expressing the GFP transgene.

54 enetics permits human artificial chromosome (HAC) formation but is not sufficient to avoid rampant mu

55 ions to support human artificial chromosome (HAC) formation was assessed by transfection into human H

56 Human artificial chromosome (HAC) technology has developed rapidly over the past four

57 We have used a human artificial chromosome (HAC) to manipulate the epigenetic state of chromatin wit

58 A human artificial chromosome (HAC) vector was constructed from a 1-Mb yeast artificial

59 y, we show that human artificial chromosome (HAC) vectors based on alpha-satellite (alphoid) DNA from

60 de novo formed Human Artificial Chromosome (HAC) was analyzed.

61 Human artificial chromosome (HAC)-based vectors offer a promising system for delivery

62 Human artificial chromosome (HAC)-based vectors represent an alternative technology f

63 Human artificial chromosome (HAC)-based vectors represent an alternative technology f

64 of a synthetic human artificial chromosome (HAC).

65 ESc) utilizing human artificial chromosomes (HAC), which behave as autonomous endogenous host chromos

66 Human artificial chromosomes (HACs) are a potentially powerful technique for genomic e

67 Human artificial chromosomes (HACs) can be formed de novo by transfection of large fra

68 Human artificial chromosomes (HACs) provide a unique opportunity to study kinetochore

69 Prior human artificial chromosomes (HACs) required large arrays of centromeric alpha-satelli

70 n of BAC-based human artificial chromosomes (HACs) requires optimization of each key functional unit

71 development of human artificial chromosomes (HACs).

72 AC vectors produced megabase-sized, circular HACs containing multiple copies of alphoid fragments (60

73 e largest reservoirs for FTOHs, while cloth, HAC filters, and dust are the largest reservoirs for FOS

74 motif, which we now term HP1a Access Codes (HACs).

75 a sign of hepatic artery (HA) complication (HAC).

76 h to dispose halogenated aromatic compounds (HACs).

77 instituted the Hospital-Acquired Condition (HAC) Reduction Program, which reduces payments to the lo

78 r lint, and on heating and air conditioning (HAC) filters in 11 homes in North Carolina as part of th

79 edial femoral condyle (MFC), which contained HAC, ACC, and SCB, was dissected from the contra-lateral

80 other heterochromatin components containing HAC motifs, which in turn regulate the function and high

81 approach that efficiently forms single-copy HACs.

82 isplatin were the top 10 drugs demonstrating HAC loss at a high frequency.

83 easured neutral PFAS concentrations in dust, HAC filter, and dryer lint samples, with mean E(FTOH) co

84 ed green fluorescent protein gene-expressing HAC at high frequency, which were stably maintained with

85 allows identifying patients at low risk for HAC, for whom CTA could be avoided, and helps choosing b

86 e 17 but not the Y chromosome regularly form HACs in HT1080 human cells.

87 s can produce these 6 MMPs was obtained from HAC cultures treated with either IL-1beta, TNFalpha, or

88 non-repetitive construct can form functional HACs without CENP-B or initial CENP-A nucleosome seeding

89 ta for hospitals participating in the FY2015 HAC Reduction Program were obtained from CMS' Hospital C

90 In order to generate HACs carrying a gene of interest, one can either co-tran

91 ally inadequate in 23%, 29%, and 53% of HIC, HAC, and RS, respectively.

92 either vector or HPRT1 DNA.The 17alpha-HPRT1 HACs were less stable than those with 17alpha only, and

93 ted through its detailed characterization in HAC explants as well as in the urine of human and other

94 The synthetic arrays are competent in HAC formation when transformed into human cells.

95 In HACs, the post-DDAVP FVIII response is strongly influenc

96 ytokine-induced MMP1 and MMP13 expression in HACs.

97 elationship in centromeric tandem repeats in HACs requires the ability to manipulate repeat substruct

98 s have been reported only in small series in HACs.

99 ondary outcomes were incidence of individual HAC-OPs, facility discharge, 6-month mortality, and all-

100 significant differences in other individual HAC-OPs, facility discharge, mortality, or readmissions.

101 A new study presents a method to induce HAC centromere formation on non-repetitive templates thr

102 f the drugs based on their ability to induce HAC loss revealed that paclitaxel, gemcitabine, dactylol

103 Microdissected HACs used as fluorescence in situ hybridization probes l

104 different trends, liquid-phase HDH of mixed HACs over Pd/C and Raney Ni catalysts were studied, and

105 ated in hyaluronic acid-based nanoparticles (HAC/DOX) and intravenously administered with TRAILPEG, D

106 hese results may influence the design of new HAC gene transfer vectors.

107 In the new HAC vector, a tTS-EYFP cassette is inserted into a gene-

108 cessfully generating gene expressing de novo HAC in hESc, and is a significant step towards the genet

109 enotypic changes attributed to expression of HAC-encoded genes.

110 the structural requirements for formation of HAC vectors that might have a potential for therapeutic

111 1 amplicon system for efficient transfer of HAC DNA into two hESc.

112 We report the development of a type of HAC that functions independently of these constraints.

113 ine the construction and characterization of HACs to facilitate mammalian synthetic genome efforts.

114 m DeltaYq74 did not support the formation of HACs, indicating that the requirements for the existence

115 In presence of HACs (10(-9) mol/plate), C. lechleri essential oil was t

116 be the main reason why the HDH reactivity of HACs in the presence of NaI is rather low.

117 es on the HAC without significant effects on HAC segregation.

118 ssive chronic lymphocytic leukemia (CLL), or HAC, has not been studied.

119 ly significant HAC, defined as thrombosis or HAC requiring IVI.

120 lphoid(tetO)-HAC has an advantage over other HAC vectors because it can be easily eliminated from cel

121 lphoid(tetO)-HAC has an advantage over other HAC vectors because it can be easily eliminated from cel

122 al-associated complications of older people (HAC-OPs) include delirium, hospital-associated disabilit

123 The resultant HAC vector was introduced into human cells by lipid-medi

124 In contrast to traditional alpha-satellite HAC formation, the non-repetitive construct can form fun

125 l high-affinity engineered protein scaffold (HAC-PD1).

126 ique, Hydrazine-Aniline Cleavage sequencing (HAC-seq), to profile the m3C methylome at single-nucleot

127 A clinically significant HAC (4 thromboses, 35 HACs requiring IVI) was found in 2

128 erformance of DUS for clinically significant HAC after OLT.

129 s strategy to predict clinically significant HAC, defined as thrombosis or HAC requiring IVI.

130 were associated with clinically significant HAC.

131 We constructed four structurally similar HAC vectors, two with chromosome 17 or Y alphoid DNA (17

132 Since HACs are known as possible colon and liver cancer induce

133 For liquid-phase HDH of single HACs, hydrogenolytic scission reactivity of C-X bonds de

134 oarenes and bromoarenes in the HDH of single HACs.

135 Six HAC-PD1 radiotracer variants were developed and used in

136 able CENP-B motifs formed mitotically stable HACs in the absence of drug selection without detectable

137 ntromeric DNA formed several self-sufficient HACs that showed no uptake of genomic DNA.

138 We previously described a synthetic HAC that can be easily eliminated from cell populations

139 eously targeted to a synthetic alphoid(tetO) HAC centromere.

140 The alphoid(tetO)-HAC elimination is highly efficient when a high level of

141 To adopt the alphoid(tetO)-HAC for routine gene function studies, we constructed a

142 The recently developed alphoid(tetO)-HAC has an advantage over other HAC vectors because it c

143 The recently developed alphoid(tetO)-HAC has an advantage over other HAC vectors because it c

144 ding into the loxP site of the alphoid(tetO)-HAC in hamster CHO cells from where the HAC may be MMCT-

145 approach to re-engineering the alphoid(tetO)-HAC that allows verification of phenotypic changes attri

146 tuating heterochromatin on the alphoid(tetO)-HAC that induces fast silencing of the genes on the HAC

147 The newly modified alphoid(tetO)-HAC-based system has multiple applications in gene funct

148 duced by genes loaded into the alphoid(tetO)-HAC.

149 d shorter time with FVIII:C >=0.8 IU/mL than HAC with body weight 35 to 70 kg.

150 Recent reports show that HACs are useful gene transfer vectors in expression stud

151 The HAC has a dimeric alpha-satellite repeat containing one

152 The HAC-based assay can be applied for screening different s

153 y and causes spreading of H3K9me3 across the HAC, ultimately inactivating the centromere.

154 te expression of NBS1 and VHL genes from the HAC at physiological levels.

155 P16 domain constitutively expressed from the HAC is capable to generate chromatin changes in the HAC

156 s attributed to expression of genes from the HAC without a transfection step.

157 s attributed to expression of genes from the HAC without a transfection step.

158 capable to generate chromatin changes in the HAC kinetochore that are not compatible with its functio

159 Of the 3284 hospitals participating in the HAC program, 721 (22.0%) were penalized.

160 oach for assessing hospital penalties in the HAC Reduction Program merits reconsideration to ensure i

161 Among hospitals participating in the HAC Reduction Program, hospitals that were penalized mor

162 Penalization in the HAC Reduction Program.

163 pping of replication initiation sites in the HAC revealed that replication preferentially initiated i

164 phenotypes induced by genes loaded into the HAC.

165 Our ability to manipulate the HAC vector by recombinant genetic methods should allow u

166 an be reversed when cells are "cured" of the HAC by inactivating its kinetochore in proliferating cel

167 Importantly, no integration of the HAC DNA was observed in the hESc lines, compared with th

168 However, inactivation of the HAC kinetochore requires transfection of cells by a retr

169 eliminated from cells by inactivation of the HAC kinetochore via binding of chromatin modifiers, tTA

170 eliminated from cells by inactivation of the HAC kinetochore via binding of tTS chromatin modifiers t

171 This silencing of the HAC-encoded genes can be readily recovered by adding dox

172 Implementation of the HAC-POA program for the intervention procedures included

173 lencer caused missegregation and loss of the HAC.

174 t induces fast silencing of the genes on the HAC without significant effects on HAC segregation.

175 enous human chromosomes, suggesting that the HAC was not formed by telomere fragmentation.

176 The findings of this study suggest that the HAC-POA program is associated with small decreases in su

177 n situ hybridization probes localized to the HAC itself and not to the arms of any endogenous human c

178 We achieved this by transferring the HAC into goat fetal fibroblast cells followed by somatic

179 etO)-HAC in hamster CHO cells from where the HAC may be MMCT-transferred to the recipient human cells

180 These HACs reside in disordered regions, possess high conserva

181 This HAC exhibits normal kinetochore protein composition and

182 Here, we demonstrate the utility of this HAC, which has a unique gene acceptor site, for delivery

183 s with reduced systemic toxicity compared to HAC/DOX or free DOX combined with TRAILPEG (80% vs. 40%

184 Here, using HAC-Seq, we report comprehensive METTL2A/2B-, METTL6-, a

185 Patients with HAC show different characteristics and worse prognosis c

186 ed with only approximately 4% for the Yalpha HAC vectors, indicating that Yalpha is inefficient at fo