ライフサイエンスコーパス: HAT activity

1 ote transcription through SAGA DUB and Tip60 HAT activity.

2 G5 and hEaf6 subunits, thereby promoting MOZ HAT activity.

3 -mediated transcription and SRC-1-associated HAT activity.

4 or antagonists blocked bombesin-induced p300 HAT activity.

5 e, we examine the effect of bombesin on p300 HAT activity.

6 a), determining a relative decrease in total HAT activity.

7 inase are involved in the regulation of p300 HAT activity.

8 r by expression of TAF1 proteins that retain HAT activity.

9 at the loop mutation was not deleterious for HAT activity.

10 y suggesting that TIP60 might mediate Jade-1 HAT activity.

11 the chromatin template is dependent upon the HAT activity.

12 CREB-binding protein (CBP) was dependent on HAT activity.

13 sion in response to light via recruitment of HAT activity.

14 Yng2p functions to maintain or activate NuA4 HAT activity.

15 between CIITA and CBP is independent of CBP HAT activity.

16 GATA-1, Pit-1, and EKLF, failed to stimulate HAT activity.

17 it is unclear if these factors modulate CBP HAT activity.

18 C/EBPalpha, strongly stimulated nucleosomal HAT activity.

19 phorylated Hbo1 at T88 without affecting its HAT activity.

20 tibility complex transcription through their HAT activity.

21 by SWI/SNF-independent recruitment of Gcn5p HAT activity.

22 dification that has been linked to increased HAT activity.

23 PcA domain as necessary for this nucleosomal HAT activity.

24 ex is sufficient for this H2A/H4 nucleosomal HAT activity.

25 ex requires the coactivator protein Gcn5 for HAT activity.

26 s suggest a possible regulatory mechanism of HAT activity.

27 Here we show that CBP has intrinsic HAT activity.

28 CBP, it does not disrupt the CBP-associated HAT activity.

29 demonstrate that recombinant Gcn5p possesses HAT activity.

30 erase II (RNA Pol II)-bound BRD4 exhibits no HAT activity.

31 esponse to small-molecule inhibition of p300 HAT activity.

32 10 mug/side) also significantly decreased DH HAT activity.

33 ue to CBP/p300-allows RNA to stimulate CBP's HAT activity.

34 xt, HSII was required for the recruitment of HAT activity.

35 TFIID subunit, binds TAF1 and inhibits TAF1 HAT activity.

36 portant not only for energetics but also for HAT activity.

37 etylase, producing an enzyme with negligible HAT activity.

38 P-14 get replaced by coactivators containing HAT activity.

39 an apparent regulatory loop that stimulates HAT activity.

40 ting that Jade1/1L positively regulates HBO1 HAT activity.

41 geneous, continuous, one-step measurement of HAT activity.

42 ial function is believed to be its catalytic HAT activity.

43 rate that all subunits are important for its HAT activity.

44 c therapies involving modulation of p300/CBP HAT activity.

45 egradation of TIP60, thereby attenuating its HAT activity.

46 s been implicated in the regulation of their HAT activity.

47 ine the effect of HPV E7 on SRC-1-associated HAT activity.

48 0 is endowed with histone acetyltransferase (HAT) activity.

49 oth of which have histone acetyltransferase (HAT) activity.

50 sponsible for the histone acetyltransferase (HAT) activity.

51 wn that Tip60 had histone acetyltransferase (HAT) activity.

52 y associated with histone acetyltransferase (HAT) activity.

53 intrinsic lysine acetyl transferase (termed HAT) activity.

54 nt, p300-mediated histone acetyltransferase (HAT) activity.

55 d with endogenous histone acetyltransferase (HAT) activity.

56 of which possess histone acetyl-transferase (HAT) activity.

57 mediates inherent histone acetyltransferase (HAT) activity.

58 2.1 is a key mechanism for modulation of the HATS activity.

59 ximately 200-fold) in blocking p300 and PCAF HAT activities.

60 factor (PCAF), and directly regulates their HAT activities.

61 owth assay closely tracked transcription and HAT activities.

62 with both H4R3 histone methyltransferase and HAT activities.

63 rocyte nuclei for histone acetyltransferase (HAT) activities.

64 rotein kinase and histone acetyltransferase (HAT) activities.

65 e nucleus on 20 kPa matrices, and inhibiting HAT activity abolishes matrix stiffness effects.

66 HAT activities acetylating either histone H3 (SAGA, Ada,

67 a transcriptional coactivator with intrinsic HAT activity, activated the wild-type MDR1 promoter but

68 s a storage pool of the protein with reduced HAT activity, allowing p300 to be compartmentalized and

69 k1(+), suggesting this phenotype is due to a HAT activity, although expression of checkpoint and cell

70 ilar effect of loss of combined essential H3 HAT activities and the loss of a single essential H4 HAT

71 el functional interactive role between Tip60 HAT activity and APP in axonal transport and provide ins

72 The ARABIDOPSIS GCN5 protein has intrinsic HAT activity and can physically interact in vitro with b

73 These effects are mediated through Esa1p's HAT activity and correlate with changes within the nucle

74 TAF1 phosphorylation of TAF7 increased TAF1 HAT activity and elevated histone H3 acetylation levels

75 The bromodomain in GCN5 was dispensable for HAT activity and for transcriptional activation by stron

76 lytic domain within GCN5 necessary to confer HAT activity and have shown that in vivo activity of GCN

77 pancreatic cancer, the clinical relevance of HAT activity and histone acetylation has remained unclea

78 results suggest that both functions of GCN5, HAT activity and interaction with ADA2, are necessary fo

79 cating that autoacetylation is necessary for HAT activity and is a fully reversible process.

80 Inhibition of p38 SAPK reduced CBP HAT activity and its recruitment to the SRF.MRTF-A compl

81 sary and sufficient in vitro for nucleosomal HAT activity and lysine specificity of the intact HAT co

82 transcriptional co-activator associated with HAT activity and may play a key role in the pathogenesis

83 sient release from chromatin, disrupting its HAT activity and potentiating its kinase activity.

84 The increase in HAT activity and reduced HDAC activity in asthma may und

85 t separate regions of Tra1 contribute to the HAT activity and stability of the SAGA and NuA4 HAT modu

86 phosphorylation leads to activation of TAF1 HAT activity and stimulation of cyclin D1 and cyclin A g

87 ich would then be followed by recruitment of HAT activity and subsequent events.

88 Sas3 is required for both the HAT activity and the integrity of the NuA3 complex.

89 mes with high affinity, independent of their HAT activity and the tested TF.

90 s, and (ii) the HOX proteins may inhibit CBP HAT activity and thus function as repressors of gene tra

91 required for both SAGA-dependent nucleosomal HAT activity and transcriptional activation from chromat

92 in inhibited p300 histone acetyltransferase (HAT) activity and abrogated p300-augmented COX-2 and iNO

93 possess intrinsic histone acetyltransferase (HAT) activity and bind to each other and another HAT, p3

94 ein has intrinsic histone acetyltransferase (HAT) activity and is capable of binding the transcriptio

95 BP possesses both histone acetyltransferase (HAT) activity and scaffolding properties that directly i

96 ly, the intrinsic histone acetyltransferase (HAT) activity and transactivation domains (TAD) play ess

97 DMAP1 associated with TIP60-dependent HAT activity, and depletion of DMAP1 reduced H4K16 acety

98 ovel links between histone acetylation, Gcn5 HAT activity, and diverse processes such as transcriptio

99 nits--Elp4, Elp5, and Elp6--are required for HAT activity, and Elongator binds to both naked and nucl

100 duced increase in DH histone H3 acetylation, HAT activity, and levels of the de novo methyltransferas

101 s to decreased nuclear syndecan-1, increased HAT activity, and up-regulation of transcription of mult

102 possess intrinsic histone acetyltransferase (HAT) activity, and histone acetylation plays a major rol

103 possess intrinsic histone acetyltransferase (HAT) activity, and it has been recently proposed that th

104 In contrast, CBP/p300 and their HAT activities are essential for ligand-induced Pol II r

105 ave been deleted, respectively) deficient in HAT activity are unable to complement the ts13 defect in

106 These results demonstrate the modulation of HAT activity as a novel mechanism of transcriptional reg

107 In gel HAT activity assay demonstrates that the salt-soluble ch

108 however partially inhibited the increase in HAT activity at 1 muM.

109 Loss of the histone acetyltransferase (HAT) activity blocks oogenesis, while loss of the H2B de

110 d type GCN5, suggesting that the efficacy of HAT activity by GCN5 is not limited by the availability

111 observations suggest that inhibition of the HAT activity by HBZ is important for the development of

112 vides novel evidence for control of p300/CBP HAT activity by site-specific autoacetylation and outlin

113 ed recruitment of histone acetyltransferase (HAT) activities by sequence-specific transcription facto

114 so increased p300 histone acetyltransferase (HAT) activity by 2.5-fold and increased acetylation of p

115 a potent and specific inhibitor of p300/CBP HAT activity, C646, in order to evaluate the functional

116 +/+) mice showed decreased HDAC and enhanced HAT activity compared with Npr1(+)(/+) mice.

117 GCN5 possesses histone acetyltransferase (HAT) activity, conceptually linking transcriptional acti

118 Dysregulation of p300/CBP HAT activity contributes to various diseases including c

119 or an acetyl-CoA substrate analogue and that HAT activity correlates positively with degree of acetyl

120 sed GR-induced transcriptional activity in a HAT-activity- dependent fashion.

121 plying that the elevated CBP/p300-associated HAT activity detected in ODC transgenic skin is attribut

122 t p300 that lacks histone acetyltransferase (HAT) activity did not reverse E1A-mediated inhibition.

123 Recombinant ATAC2 has a weak HAT activity directed to histone H4.

124 in distinct contrast to other organ systems, HAT activity does not provide a critical function for he

125 To assess the specific requirement for this HAT activity during hematopoietic development, we have g

126 in heparanase-high cells diminished nuclear HAT activity, establishing syndecan-1 as a potent inhibi

127 e data document the importance of this novel HAT activity for transcriptional activation from chromat

128 ization of a second transcription-associated HAT activity from Tetrahymena macronuclei.

129 Here, we examine whether Tip60 HAT activity functions in axonal transport using Drosoph

130 act 5% inhibited HDAC activity and increased HAT activity generating glucocorticoid insensitivity.

131 is an obligatory component of transcription, HAT activity has been largely ignored in studies of the

132 histones has been reported, but nucleosomal HAT activity has not yet been documented.

133 AM, suggesting that Elp3, in addition to its HAT activity, has a second as yet uncharacterized cataly

134 ning an intrinsic histone acetyltransferase (HAT) activity, have emerged as coactivators for various

135 e transgenic mice exhibit exceptionally high HAT activity having a distinct specificity for Lys-12 in

136 sion and SRF and CBP immunocomplexes possess HAT activities in smooth muscle cells, both SRF and CBP

137 A replication fork arrest, also inhibit Hbo1 HAT activity in a p53-dependent manner.

138 Finally, recombinant Nut1 exhibits HAT activity in an in-gel assay.

139 s mutation may define a negative role of the HAT activity in antagonizing Ras function in a specific

140 find no evidence in support of an intrinsic HAT activity in BRCA2 amino-terminus.

141 High levels of HAT activity in heparanase-high cells were blocked by SS

142 otype is due to an acute requirement for CBP HAT activity in the adult as it is rescued by both suppr

143 We show that reduction of Tip60 HAT activity in the nervous system causes axonopathy and

144 netic approaches, we show that loss of Tip60 HAT activity in the presence of the Alzheimer's disease-

145 racts with Hbo1 and negatively regulates its HAT activity in vitro and in cells.

146 hat all four motifs in CBP contribute to its HAT activity in vitro and its ability to activate transc

147 mutation within the HAT domain reduced both HAT activity in vitro and transcription in vivo.

148 omains eliminates stimulation of nucleosomal HAT activity in vitro and transcriptional coactivation b

149 y should thus be broadly useful for assaying HAT activity in vitro as well as valuable in discovering

150 E1A is associated with significant HAT activity in vitro that is partly attributable to GCN

151 109) also displayed an Asf1-dependent H3-K56 HAT activity in vitro.

152 ment of Tra1-associated subunits but reduced HAT activity in vivo.

153 is necessary for Gcn5-dependent nucleosomal HAT activity in yeast extracts.

154 e associated with histone acetyltransferase (HAT) activity in that they were able to acetylate crude

155 e acetylation and histone acetyltransferase (HAT) activity in the nucleus on 20 kPa matrices, and inh

156 ssesses intrinsic histone acetyltransferase (HAT) activity in vitro.

157 possess intrinsic histone acetyltransferase (HAT) activity in vitro.

158 la and yeast have histone acetyltransferase (HAT) activity in vitro.

159 gly reduce NRT2.1 transcription and NO(3)(-) HATS activity in the wild type.

160 At 4 h after the addition of bombesin, p300 HAT activity increased 2.0-fold (P<0.01).

161 pletely abolished Jade-1 transcriptional and HAT activities, indicating that these domains are indisp

162 Autoacetylation of Rtt109 restored full HAT activity, indicating that autoacetylation is necessa

163 ndings reveal a unique role for p300 and its HAT activity, indicating that it is necessary for the li

164 ese findings indicate that the Brd1-mediated HAT activity is crucial for efficient activation of Cd8

165 ed transgenic mice that express CBP in which HAT activity is eliminated.

166 mains unknown, as it has been shown that MOZ HAT activity is not required either for its role as Runx

167 or with intrinsic histone acetyltransferase (HAT) activity, is specifically recruited to the NF-Y com

168 vels of heparanase would result in increased HAT activity leading to stimulation of protein transcrip

169 osure to light stimulation, NGF-1-associated HAT activity leads to histone H3 acetylation and transcr

170 HAT activity maps to the central, most conserved portion

171 MCM2 and ORC1, suggest that HBO1-associated HAT activity may play a direct role in the process of DN

172 Here, we show that Tip60 HAT activity mediates axonal growth of the Drosophila pa

173 Together, our data suggest that p300 HAT activity mediates critical growth regulatory pathway

174 Moreover, the coactivator HAT activity must be tethered to the template by Tax and

175 To our knowledge, this is the only such HAT activity mutation isolated in a CBP/p300 family prot

176 imics the effects of Twist by inhibiting the HAT activities of p300 and PCAF.

177 In conclusion, the HAT activities of the co-activators are not necessary fo

178 However, whether the HAT activity of any of these proteins is required for ge

179 ere, we show that E1A directly represses the HAT activity of both p300/CBP and PCAF in vitro and p300

180 These observations suggest that HAT activity of BRCA2 may play an important role in the

181 l activators enhance the nucleosome-directed HAT activity of CBP and suggest that nuclear factors may

182 o information on the molecular structure and HAT activity of CBP in the Lymnaea central nervous syste

183 Zta stimulated the HAT activity of CBP that had been partially purified or

184 he bromodomain is functionally linked to the HAT activity of co-activators in the regulation of gene

185 The HAT activity of dTAF(II)230 resembles that of yeast and

186 show that mutations that impair the in vitro HAT activity of Elp3 confer typical elp phenotypes such

187 rase (HAT) complex, where Ada2 increases the HAT activity of Gcn5 and interacts with transcriptional

188 PT3/GCN5 interaction domain of TRRAP and the HAT activity of GCN5.

189 Here, we demonstrate that the HAT activity of Gcn5p is critical for transcriptional ac

190 eover, that the phosphorylation inhibits the HAT activity of hGCN5.

191 ogether, our findings suggest a role for the HAT activity of LymCBP in synaptic plasticity in the fee

192 ues affects the autoacetylation activity and HAT activity of MOF by various degrees demonstrating tha

193 ken together, our results establish that the HAT activity of MOF is required to sustain MLL-AF9 leuke

194 this study that mice exclusively lacking the HAT activity of MOZ exhibit significant defects in the n

195 However, the specific function of the HAT activity of MOZ remains unknown, as it has been show

196 ts reveal the functional significance of the HAT activity of p300 and define an indirect mode for the

197 The catalytic HAT activity of p300 is decreased due to occlusion of th

198 the HAT activity, showed that the intrinsic HAT activity of p300 is not required for the negative re

199 a oncoprotein and pp32 strongly inhibits the HAT activity of p300/CBP and PCAF by histone masking.

200 correlated with EBF's ability to repress the HAT activity of p300/CBP in vivo and in vitro.

201 n this study, we found that HBZ inhibits the HAT activity of p300/CBP through the bZIP domain of the

202 ation at endogenous target genes through the HAT activity of p300/CBP.

203 es and nucleosomes, although the nucleosomal HAT activity of SAS complex is very weak when compared w

204 The HAT activity of SRC-1 maps to its carboxy-terminal regio

205 ated transcription that is attenuated by the HAT activity of the AR co-activator Tip60, suggesting in

206 Instead, the HAT activity of the ATM-Tip60 complex is specifically ac

207 EVI1 in nuclear speckles requires the intact HAT activity of the co-activators.

208 dundancy must be specifically related to the HAT activity of these complexes.

209 X due to the role of Rvb1 in maintaining the HAT activity of Tip60/NuA4, implicating the Rvb1-Tip60 c

210 enes requires the histone acetyltransferase (HAT) activities of CREB-binding protein (CBP), p300, and

211 have tested for Histone acetyl transferase (HAT) activity of BRCA2.

212 The histone acetyltransferase (HAT) activity of CBP does not play a role in the transac

213 vity requires the histone acetyltransferase (HAT) activity of p/CAF but not that of CBP.

214 d increase in the histone acetyltransferase (HAT) activity of recombinant CBP-1.

215 H3 acetylation or histone acetyltransferase (HAT) activity of SAGA.

216 ulate nucleosomal histone acetyltransferase (HAT) activity of the CREB binding protein (CBP) in vitro

217 required for the histone acetyltransferase (HAT) activity of the Tip60 complex, and histone H4 acety

218 onal change and significantly increases p300 HAT activity on histone H3K18 residues, which, in turn,

219 that the Tudor-knot domain regulates KAT5's HAT activity on nucleosomes by fine-tuning substrate acc

220 or transcription function independent of the HAT activity on the viral long terminal repeat.

221 HDAC and reduced histone acetyltransferase (HAT) activity; on the contrary, Npr1(++/+) mice showed d

222 abolished by a mutation that eliminated its HAT activity or by deleting the ADA2 gene encoding a str

223 Through its intrinsic HAT activity, PCAF can further potentiate the p300 effec

224 The chromatin-bound HAT activities predominantly target H4 to give the diace

225 HAT activities present in this fraction target histones

226 in prokaryotes and insect cells did not show HAT activity, recombinant PfMYST purified from the paras

227 ition of CBP/p300 histone acetyltransferase (HAT) activity restored the altered binding patterns of B

228 ing several yeast histone acetyltransferase (HAT) activities result in either no cellular phenotype o

229 t overexpress a mutant p300, which lacks the HAT activity, showed that the intrinsic HAT activity of

230 igh cells to anacardic acid, an inhibitor of HAT activity, significantly suppressed their expression

231 ongly suggesting that Jade-1 associates with HAT activity specific for histone H4.

232 ignificantly increased bombesin-induced p300 HAT activity suggesting that Src kinase and PKCdelta kin

233 Conversely, MYC inhibits BRD4's HAT activity, suggesting that MYC regulates its own tran

234 not affect Gcn5's histone acetyltransferase (HAT) activity, suggesting that modification of Gcn5 with

235 rase), containing histone acetyltransferase (HAT) activity, target genomic loci to increase promoter

236 P300 and CBP copurify with the principal HAT activities that bind to EBNA2 or VP16 acidic domains

237 Here we show that recombinant Sas2 has HAT activity that absolutely requires Sas4 and is stimul

238 rinsic kinase and histone acetyltransferase (HAT) activities that activates transcription of key prot

239 ssesses intrinsic histone acetyltransferase (HAT) activity that is important for gene regulation.

240 ranscriptional activation by inhibiting p300 HAT activity, thereby suppressing p52 acetylation, bindi

241 ific promoters and in the regulation of p300 HAT activity through the involvement of the SANT domain.

242 tional activation through the recruitment of HAT activity to an activator-bound promoter.

243 ese observations therefore link an essential HAT activity to cell cycle progression, potentially thro

244 and this finding indicates the importance of HAT activity to Enok's function.

245 SNF remodeling controls recruitment of Gcn5p HAT activity to many genes in late mitosis and that thes

246 the STAGA complex, which helps recruit GCN5 HAT activity to Myc during transcription activation.

247 Targeting CBP-associated HAT activity to specific promoters may therefore be a me

248 requirement for SWI/SNF in recruiting Gcn5p HAT activity to the GAL1 promoter, and GAL1 expression a

249 require different histone acetyltransferase (HAT) activities to activate transcription.

250 and Rtt109-Vps75 complexes displayed reduced HAT activity toward these mutant H3/H4 tetramers.

251 of chromosomal rearrangements that associate HAT activity, transcriptional coactivation, and acute le

252 HAT activity was important to keratinocyte cathelicidin

253 nding protein-associated factor) expression, HAT activity was increased in subjects with asthma.

254 HAT activity was reduced to control levels in subjects w

255 .1 transcript accumulation in the roots, the HATS activity was still down-regulated in the 35S::NRT2.

256 g pathways involved in bombesin-induced p300 HAT activity, we examined Src and PKCdelta pathways that

257 ene-expression regulation that might involve HAT activity, we PCR-amplified Tip60 from a human heart

258 yndecan-1 had significantly higher levels of HAT activity when compared with cells or tumors expressi

259 Thus E1A carries HAT activity when complexed with CBP.

260 c kinase siRNA blocked bombesin-induced p300 HAT activity, whereas PKCdelta inhibitors or PKCdelta si

261 PKCdelta signaling pathways, activates p300 HAT activity which leads to enhanced acetylation of AR r

262 yeast, possesses histone acetyltransferase (HAT) activity which has been linked to GCN5's role in tr

263 we present evidence that BRCA2 has intrinsic HAT activity, which maps to the amino-terminal region of

264 s the presence of histone acetyltransferase (HAT) activity, which enables p300/CBP to modify nucleoso

265 A alters HDAC and histone acetyltransferase (HAT) activity, which suggests a role for HAT/HDAC homeos

266 eling through its histone acetyltransferase (HAT) activity, while promoter-associated BRD4 regulates

267 locked by pharmacological inhibition of p300/HAT activity with curcumin or by p300 small interfering

268 next examined whether bombesin-induced p300 HAT activity would result in enhanced AR acetylation.