ライフサイエンスコーパス: HDL

1 HDL brings more power to genomic analyses and better rev

2 HDL from CKD rabbits and patients on hemodialysis exhibi

3 HDL from CKD rabbits and patients on hemodialysis had HN

4 HDL markers were analyzed in adjusted Cox proportional h

5 HDL NPs are a cholesterol-poor ligand that binds to the

6 HDL subsequently delivers effluxed cholesterol to the li

7 HDL-C raising genetic variants in the gene locus of the

8 HDL-cholesterol concentrations after the milk diet were

9 HDL-P was inversely associated with MI among White parti

10 HDL-P was inversely associated with the individual end p

11 r capabilities of our lead candidate MTP(10)-HDL in a B16F10 mouse melanoma model.

12 Furthermore, MTP(10)-HDL nanotherapy potentiates checkpoint inhibition in thi

13 Finally, we determined MTP(10)-HDL's favorable biodistribution and safety profile in no

14 ipoprotein B (n = 255), triglycerides (440), HDL cholesterol (534), and apolipoprotein A-I (440).

15 In the overall population (n=15 784), HDL-P was inversely associated with the combined outcome

16 increases of the TG-component in almost all HDL (high-density lipoprotein) subparticles (HDL-TG), a

17 latelet aggregation, suggesting that altered HDL properties may contribute to the increased cardiovas

18 Paraoxonase 1(PON1) is an HDL-associated protein, which metabolizes inflammatory,

19 0.04; 5-OHTrp(72) apoA-I, 2.35 +/- 0.0; and HDL, 2.33 +/- 0.1; p < 0.001, p < 0.001, and p < 0.001,

20 (95% CI: 3.01, 17.94; I(2) = 84%, N=16) and HDL-cholesterol by 4.00 mg/dL (95% CI: 2.26, 5.73; I(2)

21 ference (WC) (OR 0.98, 95% CI 0.96-0.99) and HDL-C (OR 0.99, 95% CI 0.98-0.99) was associated with si

22 leiotropic effects associated with LDL-c and HDL-c SNPs.

23 Differential associations of both HDL-C and HDL-P for MI by Black ethnicity suggest that atheroscler

24 The associations of HDL-C and HDL-P with ischemic stroke and myocardial infarction (MI

25 ilable measures of serum LDL cholesterol and HDL cholesterol concentrations.

26 ion was largely attenuated for SBP, DBP, and HDL-C.

27 Decreased levels of apoA-I and HDL cholesterol were robustly associated with increased

28 were LDL cholesterol 3.57 (0.87) mmol/L and HDL cholesterol 1.45 (0.38) mmol/L, and the median trigl

29 (triglycerides >150 mg/dl [1.69 mmol/l] and HDL-C <40 mg/dl [1.03 mmol/l] in men or <50 mg/dl [1.29

30 h low- and high-density lipoprotein (LDL and HDL) cholesterol, triglycerides, and apolipoprotein A-I

31 low- and high-density lipoproteins [LDL and HDL], triglycerides [TGs], and glycated haemoglobin [HbA

32 es to test the association between apo M and HDL-associated S1P.

33 ip between long-term functional recovery and HDL proteome and function.

34 ontrol subject after adjustments for sex and HDL-C levels, 12 proteins some of which participate in a

35 hosts, containing higher levels of total and HDL-cholesterol, grew larger tumors than apoA1-KO hosts

36 poA1-KO hosts with lower levels of total and HDL-cholesterol.

37 lated to genetic risk from triglycerides and HDL-C as from LDL-C.

38 iprocal genetic effects on triglycerides and HDL-C.

39 in BMI, fasting glucose, triglycerides, and HDL cholesterol in individuals randomized to metformin o

40 itiates nascent high-density apolipoprotein (HDL) biogenesis by transferring phospholipid and cholest

41 We apply HDL and LDSC to estimate 435 genetic correlations among

42 arly affect circulating lipoproteins such as HDL that exhibit antiatheromatous and antithrombotic pro

43 sociated with an increased risk for all BCs (HDL: OR [odds ratio] = 1.08, 95% confidence interval [CI

44 Buprenorphine appears to produce beneficial HDL- and craving effects and, contrary to methadone, its

45 exposure duration was associated with better HDL and opioid craving values.

46 However, to date, the association between HDL functional characteristics and acute coronary syndro

47 or HDL-P attenuated all associations between HDL-C and events.

48 t attenuate the inverse relationship between HDL-P and atherosclerotic cardiovascular disease, wherea

49 els of the beneficial lipoprotein biomarkers HDL and ApoA1, as well as total bile acids.

50 Differential associations of both HDL-C and HDL-P for MI by Black ethnicity suggest that a

51 Compared with HDL-C, HDL-P was consistently associated with MI and ischemic s

52 (PLP), and total B-12 with serum TC, LDL-C, HDL-C, and TG concentrations across trimesters.

53 ed the following functional characteristics: HDL cholesterol concentration (in plasma); cholesterol e

54 0.036) and positively with HDL cholesterol (HDL-C) (beta = 0.442, 95% CI (0.011,0.873), p = 0.045).

55 luding high-density lipoprotein cholesterol (HDL-C) (beta 0.40, 95% confidence interval (CI), 0.04-0.

56 ), non-high-density lipoprotein cholesterol (HDL-C) (HR: 1.05; 95% CI: 1.01 to 1.10, per 10 mg/dl [0.

57 DL-c), high density lipoprotein cholesterol (HDL-c) and triglycerides (TG) from two independent GWAS

58 els of high-density lipoprotein cholesterol (HDL-C) decline drastically during sepsis, and this pheno

59 plasma high-density lipoprotein cholesterol (HDL-C) increase and, potentially, a reduced cardiovascul

60 nd non-high-density lipoprotein cholesterol (HDL-C) level on the expected rates of atherosclerotic ca

61 (DBP), high-density-lipoprotein cholesterol (HDL-C), and glycated haemoglobin (HbA1c).

62 (TC), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C)

63 DL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) were evaluated preconcept

64 els of high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and

65 els of high-density lipoprotein cholesterol (HDL-C).

66 erol), high-density lipoprotein cholesterol (HDL-cholesterol), total cholesterol, triglycerides, meas

67 6 studies; 168,553 people], HDL-Cholesterol [HDL-C; 84 studies; 121,282 people], LDL-Cholesterol [LDL

68 I, systolic blood pressure, LDL cholesterol, HDL cholesterol, triglycerides, and fasting glucose) to

69 droxyvitamin D [25(OH)D], total cholesterol, HDL cholesterol, apoA-I, apoB, and C-reactive protein (C

70 sting lipid measurements (total cholesterol, HDL-C, non-HDL-C, direct and calculated low-density lipo

71 altered the proteomic profile of circulating HDL and ameliorated some of the potentially harmful chan

72 lipoprotein (HDL) cholesterol concentration (HDL-C) is an established atheroprotective marker, in par

73 isease; however, HDL particle concentration (HDL-P) may better predict risk.

74 dependent of the leading association at core HDL pathway genes and found that these variants were als

75 d higher inflammatory markers (WBC and CRP), HDL and insulin resistance (p < 0.001).

76 increased plasma triglycerides and decreased HDL cholesterol levels, is a major factor contributing t

77 ve protein levels (P = 0.003), and decreased HDL-cholesterol levels (P = 0.009) than the women withou

78 eased body fat; adverse effects on decreased HDL, and increased risks of prostate cancer, androgenic

79 ated cholesterol efflux by 53% demonstrating HDL-C functionality.

80 mHg for systolic or >=85 mmHg for diastolic, HDL cholesterol <40 mg/dL for males and <50 mg/dL for fe

81 t differences in the morphology of different HDL preparations that are not detected by TEM.

82 he presence of total cholesterol >200 mg/dL, HDL <40 mg/dL, LDL >130 mg/dL, and TGs >150 mg/dL were 1

83 l phospholipids or by oxPLs generated during HDL oxidation in plasma by the physiologically relevant

84 protein dicarbonyl adducts and dysfunctional HDL.

85 eous solubility and low levels of endogenous HDL acceptors in target patient populations limit the cl

86 the spleen and bone marrow by in vivo (19)F-HDL magnetic resonance imaging.

87 The (19)F-HDL nanotracer can additionally be labelled with zirconi

88 with a perfluoro-crown ether payload ((19)F-HDL) to allow myeloid cell tracking by (19)F magnetic re

89 g/dl) were 193 for TC, 120 for LDL-C, 47 for HDL-C, and 139 for TG; no strong trends.

90 onal logistic regression models adjusted for HDL cholesterol levels and cardiovascular risk factors t

91 Adjustment for HDL-C did not attenuate the inverse relationship between

92 rdiovascular disease, whereas adjustment for HDL-P attenuated all associations between HDL-C and even

93 , no significant associations were found for HDL and triglycerides (both p > 0.05).

94 menarche, corroborated this observation for HDL (OR = 1.06, 95% CI = 1.03-1.10, P = 4.9 x 10-4) and

95 improvements were additionally observed for HDL cholesterol and for the ratio of total to HDL choles

96 No differences were seen for HDL, LDL and cholesterol.

97 For this endpoint, the interaction term for HDL-C and type of MI was significant even after adjustme

98 a rapid transfer of the radiolabeled UC from HDL to LDL occurred.

99 fferences were found in glycated hemoglobin, HDL-cholesterol, or triglyceride concentrations.

100 inked to myocardial infarction, whereas high HDL oxidative-inflammatory index values (OR(1SD), 1.53;

101 Higher HDL oxidative inflammatory index values were marginally

102 nalyses showed a 1-standard-deviation-higher HDL cholesterol (OR 0.80; 95% CI: 0.75-0.86; P < 0.001)

103 Genetic predisposition to higher HDL-C levels was associated with lower risk of small ves

104 Genetic predisposition to higher HDL-C, specifically to cholesterol in medium-sized high-

105 icular for coronary artery disease; however, HDL particle concentration (HDL-P) may better predict ri

106 f apoprotein cross-linking in isolated human HDL either by synthetic gamma-ketoalkenal phospholipids

107 lipids effectively cross-link apoproteins in HDL.

108 % (95% CI: -5.8%, -0.6%; P = 0.02) change in HDL cholesterol.

109 t there were no other significant changes in HDL functions or antioxidant or inflammatory markers.

110 Changes in HDL protein composition and function (cholesterol efflux

111 Changes in HDL proteins during early acute phase of stroke associat

112 ses in insulin and glucose, and decreases in HDL cholesterol and ghrelin (Ps < 0.05).

113 Although most Saa3 was found in HDL, a small amount was not lipoprotein associated.

114 deviation genetically determined increase in HDL levels is associated with an increased risk for all

115 ration, a 28% (+/-21%; p < 0.05) increase in HDL-C and 14% (+/-20%; p < 0.05) decline in LDL-C.

116 A 10 mg/dL increase in HDL-C change from preconception to 28 weeks was associat

117 For >=25 BMI only, 10 mg/dL increase in HDL-C change was associated with decreased SGA odds (OR

118 [95% CI, 0.59-1.00] per 1 mmol/L increase in HDL-C) and iSPAAR cohorts (hazard ratio, 0.60 [95% CI, 0

119 [95% CI, 0.37-0.98] per 1 mmol/L increase in HDL-C).

120 odds ratios (ORs) between 1-SD increments in HDL functional characteristics and clinical outcomes.

121 r, alcohol was associated with and increased HDL-C, decreased TRG, and increased BP, which may indica

122 increased testosterone, free androgen index, HDL and CRP (P < 0.01).

123 hod provides new morphological insights into HDL comprising a naturally occurring apolipoprotein A-I

124 hromatography-mass spectrometry and isolated HDL particles to test the association between apo M and

125 The S1P and apo M content of isolated HDL particles strongly correlated (R=0.81, P<0.0001).

126 particles, small HDL, medium HDL, and large HDL, were isolated by high-resolution size exclusion chr

127 Increased large and extra-large HDL levels and decreased VLDL and amino acid levels were

128 lites belonging to the large and extra-large HDL subclasses.

129 Total cholesterol, LDL, HDL, and triglyceride were evaluated at 3 months (n = 26

130 pid-related SNPs for total cholesterol, LDL, HDL, and triglycerides, respectively.

131 Compared to LDSC, HDL reduces the variance of genetic correlation estimate

132 me, we develop a high-definition likelihood (HDL) method to improve precision in genetic correlation

133 subjects (11.6%); high-density lipoprotein (HDL) <40 mg/dL, 2,078 subjects (5.3%); low-density lipop

134 /L, p < 0.001) and high-density lipoprotein (HDL) (0.90 to 1.55 mmol/L, p < 0.001) were increased, wh

135 erol to endogenous high-density lipoprotein (HDL) acceptors.

136 ein constituent of high-density lipoprotein (HDL) and a target of myeloperoxidase-dependent oxidation

137 nt modification of high-density lipoprotein (HDL) apoproteins by endogenous oxidized phospholipids (o

138 al cholesterol and high-density lipoprotein (HDL) cholesterol (all p < 0.05).

139 were conducted for high-density lipoprotein (HDL) cholesterol and apolipoprotein A-I.

140 clear link between high-density lipoprotein (HDL) cholesterol and cardiovascular disease, leading to

141 rease in levels of high-density lipoprotein (HDL) cholesterol and triglycerides.

142 High-density lipoprotein (HDL) cholesterol concentration (HDL-C) is an established

143 yceride level, low high-density lipoprotein (HDL) cholesterol level, impaired fasting glucose level,

144 mes by circulating high-density lipoprotein (HDL) complexes called trypanosome lytic factors (TLFs) 1

145 ome, distinct from high-density lipoprotein (HDL) isolated from donor plasma of the same individuals.

146 High-density lipoprotein (HDL) metabolism is facilitated in part by scavenger rece

147 ogical function of high-density lipoprotein (HDL) nanoparticles, the so-called good cholesterol that

148 nteraction between high-density lipoprotein (HDL) particles and sphingosine-1-phosphate (S1P).

149 ential role of the high-density lipoprotein (HDL) receptor as a target for cholesterol depleting ther

150 s phospholipids in high-density lipoprotein (HDL) resulting in reduction in plasma HDL levels.

151 ge and extra-large high-density lipoprotein (HDL) subclasses and decreased levels of very low-density

152 and composition of high-density lipoprotein (HDL) that occurs with COVID-19 can significantly decreas

153 chaperone ApoM(+) high density lipoprotein (HDL), which signals via endothelial niche S1PR1 to spur

154 tion, and a higher high-density lipoprotein (HDL-C) is thought to be protective.

155 iglyceridemia, low high-density lipoprotein [HDL], and elevated blood pressure) (P-trend for all test

156 cholesterol, LDL, high-density lipoprotein [HDL], and triglycerides) using independent genomewide si

157 asma lipid traits (high-density lipoprotein, HDL; low-density lipoprotein, LDL; triglycerides, TGs) w

158 ter values of the high-density lipoproteins (HDL).

159 ate lipid metabolism including lipoproteins (HDL, LDL), neutral (triglycerides, cholesterol) and pola

160 cholesterol onto high-density lipoproteins (HDLs), but other mechanisms for cholesterol efflux likel

161 fer to be the contested high-density liquid (HDL).

162 idant/proinflammatory HDL particles, and low HDL levels of sphingosine-1-phosphate and apolipoprotein

163 bnormalities, including type 2 diabetes, low HDL, high triglycerides, and female-specific overweight

164 ed with an elevated risk of experiencing low HDL-C and high TG (all p < 0.05).

165 for high TC, 20% for high LDL-C, 48% for low HDL-C, and 21% for high TG; no strong trends.

166 igher levels statistically in cases with low HDL cholesterol level, high LDL cholesterol level, high

167 For NSTEMI patients, a lower HDL-C was associated with a higher risk of death during

168 ospitalization but in STEMI patients a lower HDL-C was paradoxically associated with a lower risk of

169 ipopolysaccharide-binding protein, and lower HDL cholesterol (P ranging from <0.001 to 0.03), reflect

170 sdLDL (44 versus 29 mg/dL, P<.01) and lower HDL-2C (9 versus 12 mg/dL, P=.001).

171 The results indicate that, besides the major HDL-dependent m-RCT pathway via SR-BI (scavenger recepto

172 ted with 2-HOBA have reduced MDA-LDL and MDA-HDL levels, and their HDL display increased capacity to

173 edian triglycerides level, 240 mg/dL; median HDL-C level, 36 mg/dL; and median high-sensitivity C-rea

174 ceptor class B, type 1 (SR-B1) that mediates HDL uptake into cells.

175 ee sizes of HDL particles, small HDL, medium HDL, and large HDL, were isolated by high-resolution siz

176 etic correlations observed for both methods, HDL identified another 57 significant genetic correlatio

177 s-links of apoA-I and apoA-II with two minor HDL apoproteins, apoA-IV and apoE.

178 antly higher in the presence of HNE-modified HDL than with HDL from their respective controls.

179 is and peritoneal dialysis, and HNE-modified HDL.

180 We modified HDL from controls by incubating it overnight at 37 degre

181 Monitoring HDL proteins may provide clinical biomarkers that inform

182 apoprotein cross-linking in oxidized murine HDL.

183 lesterol uptake with HDL-like nanoparticles (HDL NPs).

184 (-14.6 mg/dL, 95% CI -18.2 to -11.0) and non-HDL cholesterol (-18.4 mg/dL, -22.5 to -14.3).

185 reactive protein (CRP) were analyzed and non-HDL cholesterol calculated at baseline and after the int

186 for triglycerides, fasting glucose, and non-HDL cholesterol.

187 measurements (total cholesterol, HDL-C, non-HDL-C, direct and calculated low-density lipoprotein cho

188 all cardiometabolic risk factors except non-HDL cholesterol were stronger in women than men.

189 easures of adiposity, ~0.1 mmol/l higher non-HDL cholesterol and triglycerides and 0.2 mmol/l higher

190 as also higher with older age and higher non-HDL-C level.

191 k were greater with older age and higher non-HDL-C level.

192 ucose, and non-high-density lipoprotein (non-HDL) cholesterol using linear mixed models.

193 Levels of non-HDL-C for participants on lipid treatment were adjusted

194 : 1.1%, 2.3%, 5.4%, 10.3%, respectively; non-HDL-C: 1.1%, 2.0%, 3.7%, 5.9%, respectively).

195 ars) in 40- to 49-year-old patients with non-HDL-C >=160 mg/dL would be expected to reduce their aver

196 in individuals in their 40s and 50s with non-HDL-C >=160 mg/dL.

197 Furthermore, a novel HDL association with cg17901584 in chromosome 1 was iden

198 bating the cells overnight in the absence of HDL or serum, we visualized (13)C and (15)N distribution

199 nted for almost all of ABCA1 CEC activity of HDL.

200 further detected oxPL cross-link adducts of HDL apoproteins in plasma and aorta of hyperlipidemic LD

201 lts in vivo after systemic administration of HDL NPs in mouse lymphoma xenografts and in primary samp

202 The associations of HDL-C and HDL-P with ischemic stroke and myocardial infa

203 r cholesterol efflux capacity (ABCA1 CEC) of HDL strongly and negatively associates with cardiovascul

204 subparticles (HDL-TG), a smaller decrease of HDL diameter and smaller increases of most components of

205 d (48%; p < 0.01) lipidation and evidence of HDL biogenesis.

206 inflammatory and anti-oxidative functions of HDL and could contribute to pulmonary inflammation.

207 ntrations, resulting in smaller increases of HDL-TG and VLDL subparticles.

208 5% CI 0.38-0.76]; P < 0.001), independent of HDL cholesterol levels (P = 0.015), adiposity (P = 0.018

209 This relationship was independent of HDL cholesterol or apo AI levels.

210 n, elevated triglycerides, reduced levels of HDL cholesterol and glucose impairment) on the phenotype

211 ng triglycerides, and having lower levels of HDL cholesterol.

212 Higher levels of HDL have been associated with protection in other diseas

213 ut inversely associated with serum levels of HDL-C after the adjustment for age, sex, and race.

214 ted with anacetrapib had preserved levels of HDL-C and apolipoprotein-AI and increased survival relat

215 nt mechanism that contributes to the loss of HDL's atheroprotective function in vivo.

216 which is characterized by a complete loss of HDL.

217 specific role of oxidative modifications of HDL in CKD and their effect on the platelet-targeting an

218 The morphology of HDL particles composed of apolipoproteins, lipids and ch

219 antiaggregative phenotype in the presence of HDL from CKD rabbits, patients on hemodialysis and perit

220 phages, and, in the simultaneous presence of HDL, a rapid transfer of the radiolabeled UC from HDL to

221 ssessment of the antiaggregant properties of HDL, we collected blood samples from 15 healthy voluntee

222 atelet-targeting antiaggregant properties of HDL, we used a CKD (5/6 nephrectomy) rabbit model.

223 The abnormal rates of HDL-C and TG increased as the students maturated through

224 hypothesis that the atheroprotective role of HDL lies in its biological activity rather than in its c

225 ved UC, thereby preventing the saturation of HDL particles and facilitating their cholesterol efflux

226 Three sizes of HDL particles, small HDL, medium HDL, and large HDL, wer

227 esterol efflux and the rate-limiting step of HDL biogenesis both in vitro and in vivo.

228 Darapladib has been found mainly bound on HDL and albumin when it is incubated with human serum.

229 tively resistant to darapladib when bound on HDL.

230 r, LDL did not exert a synergistic effect on HDL cholesterol efflux capacity in the familial hypercho

231 scavenger, 2-hydroxybenzylamine (2-HOBA) on HDL function and atherosclerosis in Ldlr(-/-) mice, a mo

232 w-density lipoprotein cholesterol (LDL-C) or HDL-C, were associated with MACEs.

233 ially d3-alpha-T enriched relative to LDL or HDL, showing the TRL precursor role.

234 the macrophages (in the absence of serum or HDL) onto smooth muscle cells (SMCs) that had been metab

235 to adjacent cells in the absence of serum or HDL.

236 holesterol [TC; 86 studies; 168,553 people], HDL-Cholesterol [HDL-C; 84 studies; 121,282 people], LDL

237 We observed that genetically elevated plasma HDL and LDL levels appear to be associated with increase

238 otein (HDL) resulting in reduction in plasma HDL levels.

239 el and demonstrated a 56% increase in plasma HDL-C.

240 mpared with 1.08 +/- 0.06), and lower plasma HDL cholesterol.

241 ivity of CETP, a major determinant of plasma HDL-C levels.

242 arch tool in the clinical analysis of plasma HDL.

243 capacity values, pro-oxidant/proinflammatory HDL particles, and low HDL levels of sphingosine-1-phosp

244 Here, reconstituted HDL formulations are oriented on glass substrates and so

245 on/stabilization compared with reconstituted HDL (WT apoA-I, 1.92 +/- 0.04; 5-OHTrp(72) apoA-I, 2.35

246 increased C-reactive protein (CRP), reduced HDL, insulin resistance as well as increased androgens c

247 perlipidemia and insulin resistance, reduced HDL-cholesterol level, increased LDL-cholesterol level,

248 CRISPR/Cas9-mediated genome editing reduces HDL uptake into the prostate cancer cells and reduces th

249 out SR-B1 in prostate cancer tumors reduces HDL-associated increases in prostate cancer cell prolife

250 triglycerides, glucose, and insulin; reduces HDLs; and may increase risk of coronary heart disease (C

251 t binds to the receptor for cholesterol-rich HDLs, scavenger receptor type B1 (SCARB1).

252 PCs were significantly correlated with serum HDL cholesterol, triglycerides, glucose, insulin, and HO

253 ormations of native APOL1 topology in serum (HDL particles) and at the podocyte surface.

254 APOL1 topology in serum (HDL particles) and in kidney podocytes was mapped with f

255 Similarly, HDL-C was inversely associated with MI among White parti

256 Small HDL accounted for almost all of ABCA1 CEC activity of HD

257 both HFrEF and HFpEF, total HDL-P and small HDL-P were inversely associated with time to adverse eve

258 Enriching small HDL with SERPINA1 enhanced ABCA1 CEC.

259 SERPINA1 (serpin family A member 1) in small HDL was also lower in subjects with diabetes mellitus.

260 The ABCA1 CEC of small HDL is selectively impaired in type 2 diabetes mellitus,

261 Thus, impaired ABCA1 activity of small HDL particles deficient in SERPINA1 could increase cardi

262 ABCA1 CEC-but not ABCG1 CEC-of small HDL was lower in the subjects with type 2 diabetes melli

263 Three sizes of HDL particles, small HDL, medium HDL, and large HDL, were isolated by high-re

264 8 per 1 SD, 95%CI = (1.42, 1.65) in SNP363); HDL-c was strongly associated with reduced risk for CAD

265 ficantly (adjusted P<0.05) altered in stroke HDL at 96 hours.

266 HDL (high-density lipoprotein) subparticles (HDL-TG), a smaller decrease of HDL diameter and smaller

267 01317 (T1317), by encapsulating in synthetic HDL (sHDL) nanoparticles.

268 gether, these results suggest that targeting HDL interactions with BrM represents a new strategy to s

269 higher in the UK cohort whilst testosterone, HDL and CRP were higher in the Middle East population.

270 g despite adjusting for baseline weight, TG, HDL-C and HbA1c (p = 0.002).

271 We hypothesized that HDL-P would consistently be associated with MI and strok

272 These analyses indicate that HDL-C raising strategies could be considered for the pre

273 Our data reveal that HDL NP treatment activates a compensatory metabolic resp

274 pacity; antioxidant ability, measured by the HDL oxidative-inflammatory index; phospholipase A2 activ

275 educed MDA-LDL and MDA-HDL levels, and their HDL display increased capacity to reduce macrophage chol

276 14 mg/dL; p=0.004), and total cholesterol to HDL ratio (-0.1 vs -0.3; p=0.007) at week 144; no differ

277 d reduces their proliferation in response to HDL.

278 DL cholesterol and for the ratio of total to HDL cholesterol.

279 In both HFrEF and HFpEF, total HDL-P and small HDL-P were inversely associated with tim

280 However, the total/HDL cholesterol ratio did not significantly decrease due

281 interaction analyses on three lipid traits (HDL-c, LDL-c and triglycerides).

282 were no group differences in triglycerides, HDL cholesterol, glucose, insulin, insulin resistance, l

283 on was associated with worse triglycerides-, HDL-, blood pressure-, fasting glucose- and hemoglobin A

284 le 1 [Q1], 0.64 [95% CI, 0.52-0.78]), as was HDL-C (HR for Q4 versus Q1, 0.76 [95% CI, 0.61-0.94]).

285 Whether HDL cholesterol exerts a protective effect on ischemic s

286 t consumption was positively associated with HDL cholesterol.

287 Compared with HDL-C, HDL-P was consistently associated with MI and isc

288 stroke among women and Blacks compared with HDL-C.

289 ly higher when platelets were incubated with HDL from CKD rabbit and hemodialysis groups than with HD

290 y associated with birthweight outcomes, with HDL-C more strongly associated with healthy birthweight

291 24, - 0.016), p = 0.036) and positively with HDL cholesterol (HDL-C) (beta = 0.442, 95% CI (0.011,0.8

292 In summary, targeting SCARB1 with HDL NPs in cholesterol uptake-addicted lymphoma cells ab

293 CKD rabbit and hemodialysis groups than with HDL from the control group.

294 n the presence of HNE-modified HDL than with HDL from their respective controls.

295 culture media either alone or together with HDL or ex vivo by plasma derived from subjects with fami

296 to the reduction of cholesterol uptake with HDL-like nanoparticles (HDL NPs).

297 Results: A significant reduction in (89)Zr-HDL accumulation was observed in PET/CT images, with 2.9

298 results support the potential use of (89)Zr-HDL nanoparticles as a PET tracer to quickly monitor the

299 The accumulation of (89)Zr-HDL within the tumor was assessed using PET/CT imaging a

300 )Zr-labeled high-density lipoprotein ((89)Zr-HDL) nanotracer as a means of monitoring response to imm