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1                                              HNF-1beta and beta-catenin/LEF compete for binding to th
2                                              HNF-1beta and the structurally related HNF-1alpha bind s
3                                              HNF-1beta binds to the SOCS3 promoter and represses SOCS
4                                              HNF-1beta binds to two evolutionarily conserved sites lo
5                                              HNF-1beta directly regulates the transcription of Pkhd1,
6                                              HNF-1beta is a tissue-specific transcription factor that
7                                              HNF-1beta mutant cells also expressed lower levels of ch
8                                              HNF-1beta mutant kidneys showed increased expression of
9  63% HNF-1alpha, 2% HNF-4alpha, 0% IPF-1, 1% HNF-1beta, 0% NeuroD1/ BETA2, and 20% glucokinase.
10 HNF-4alpha, insulin promoter factor (IPF)-1, HNF-1beta, and NeuroD1/BETA2, all resulting in early-ons
11 gated to the coding sequence for HNF-1alpha, HNF-1beta, HNF-3, or HNF-4 completely restored the PKA r
12 tion factor hepatocyte nuclear factor 1beta (HNF-1beta) is essential for normal development of the ki
13 ial role of hepatocyte nuclear factor-1beta (HNF-1beta) in regulating PPARGC1A expression in AKI.
14             Hepatocyte nuclear factor-1beta (HNF-1beta) is a homeodomain-containing transcription fac
15             Hepatocyte nuclear factor-1beta (HNF-1beta) is a Pit-1, Oct-1/2, Unc-86 (POU) homeodomain
16             Hepatocyte nuclear factor-1beta (HNF-1beta) is a Pit-1, Oct-1/2, UNC-86 (POU)/homeodomain
17             Hepatocyte nuclear factor-1beta (HNF-1beta) is a tissue-specific transcription factor tha
18             Hepatocyte nuclear factor-1beta (HNF-1beta) is a tissue-specific transcription factor tha
19             Hepatocyte nuclear factor-1beta (HNF-1beta) is a transcription factor that regulates gene
20 tion factor hepatocyte nuclear factor-1beta (HNF-1beta) is essential for normal kidney development an
21 tion factor hepatocyte nuclear factor-1beta (HNF-1beta) regulates tissue-specific gene expression in
22 tion factor hepatocyte nuclear factor-1beta (HNF-1beta), mutations of which produce kidney cysts.
23 al similarity between HNF-1alpha and -1beta, HNF-1beta mutation carriers have hyperinsulinemia, where
24                                           An HNF-1beta deletion mutant lacking the C-terminal domain
25                             Expression of an HNF-1beta C-terminal deletion mutant in transgenic mice
26  gene expression profiling, we found that an HNF-1beta target gene in the kidney is kinesin family me
27 inding factor (LEF) site overlapping with an HNF-1beta half-site.
28  and -1alpha, insulin promoter factor-1, and HNF-1beta are the causes of four forms of maturity-onset
29 nal heterodimerization of the HNF-1alpha and HNF-1beta proteins.
30 e relationship between HNF-1beta binding and HNF-1beta-dependent gene regulation, RNA-seq was perform
31 tions in HNF-1beta develop kidney cysts, and HNF-1beta regulates the transcription of several cystic
32 he proteins encoded by Srebf2 and Hmgcr, and HNF-1beta directly controlled the renal epithelial expre
33 rmed on UB cells purified from wild-type and HNF-1beta mutant embryonic kidneys.
34 y increasing DRA expression via the RAR-beta/HNF-1beta-dependent pathway.
35      To investigate the relationship between HNF-1beta binding and HNF-1beta-dependent gene regulatio
36 and RBP-J results in down-regulation of both HNF-1beta and Sox9 (sex determining region Y-related HMG
37 nalysis of UB-derived cells showed that both HNF-1beta-dependent activation and repression correlated
38  Sema3d, Sema6a, and Slit2 were activated by HNF-1beta, whereas Efna1, Epha3, Epha4, Epha7, Ntn4, Plx
39 icating that they were directly activated by HNF-1beta.
40 s and transcriptional programs controlled by HNF-1beta are poorly understood.
41 eutic approach for human diseases induced by HNF-1beta mutations.
42 seq) to identify genes that are regulated by HNF-1beta in embryonic mouse kidneys.
43 -coding genes that are directly regulated by HNF-1beta in murine kidney epithelial cells.
44 RNAs (miRNAs) that are directly regulated by HNF-1beta in renal epithelial cells.
45   This may be mediated through regulation by HNF-1beta of the key gluconeogenic enzymes glucose-6-pho
46 3, Srgap1, Unc5c and Unc5d were repressed by HNF-1beta.
47 mode of active transcriptional repression by HNF-1beta.
48 cipitation assays and PCR analysis confirmed HNF-1beta binding to the Ppargc1a promoter in mouse kidn
49                                  Conversely, HNF-1beta directly repressed the expression of 526 genes
50       Here, we used Pkhd1/Cre mice to delete HNF-1beta specifically in renal collecting ducts (CDs).
51 NA and miR-200 was decreased in kidneys from HNF-1beta knock-out mice and renal epithelial cells expr
52 e sites that are occupied by beta-catenin in HNF-1beta mutant cells colocalize with HNF-1beta-occupie
53 uidance genes may underlie kidney defects in HNF-1beta mutant mice.
54 sed in wild-type UB and were dysregulated in HNF-1beta mutant UB.
55 l of 1632 genes showed reduced expression in HNF-1beta-deficient UB cells, and 485 genes contained ne
56  revealed downregulated expression of FXR in HNF-1beta mutant kidneys.
57 atment resulted in a significant increase in HNF-1beta mRNA levels.
58 200 targets, Zeb2 and Pkd1, was increased in HNF-1beta knock-out kidneys and in cells expressing muta
59      The expression of SOCS3 is increased in HNF-1beta knockout mice and in renal epithelial cells ex
60 n-regulated and cAMP levels are increased in HNF-1beta mutant kidney cells and mice.
61 on of Wnt target genes are also increased in HNF-1beta mutant mouse kidneys.
62 te was not suppressed by low-dose insulin in HNF-1beta subjects but was suppressed by 89% in HNF-1alp
63 f the beta-catenin-binding domain of LEF1 in HNF-1beta-deficient cells abolishes the increase in Lef1
64                     Humans with mutations in HNF-1beta develop kidney cysts, and HNF-1beta regulates
65 decreased the expression of Zeb2 and Pkd1 in HNF-1beta mutant cells.
66           Functional studies of R137-K161del HNF-1beta revealed that it could not bind an HNF-1 targe
67              In the developing mouse kidney, HNF-1beta is required for the differentiation and patter
68         Compared with wild-type littermates, HNF-1beta mutant mice exhibited polyuria and polydipsia.
69 k-out kidneys and in cells expressing mutant HNF-1beta.
70       Expression of dominant-negative mutant HNF-1beta in mIMCD3 cells produces hyperresponsiveness t
71       Expression of dominant negative mutant HNF-1beta or kidney-specific inactivation of HNF-1beta d
72 al cells expressing dominant-negative mutant HNF-1beta rescues the defect in HGF-induced tubulogenesi
73 al cells expressing dominant-negative mutant HNF-1beta.
74 al cells expressing dominant-negative mutant HNF-1beta.
75 m mitigated the inhibitory effects of mutant HNF-1beta on the proteins encoded by Srebf2 and Hmgcr, a
76 ent UB cells, and 485 genes contained nearby HNF-1beta binding sites indicating that they were direct
77 -1 site or expression of a dominant-negative HNF-1beta mutant inhibit Pkhd1 promoter activity in tran
78 ansgenic mice expressing a dominant-negative HNF-1beta mutant under the control of a kidney-specific
79                                  Ablation of HNF-1beta decreases H3K27 trimethylation repressive mark
80               Here, we show that ablation of HNF-1beta in mIMCD3 renal epithelial cells produces hype
81               Here, we show that ablation of HNF-1beta in mIMCD3 renal epithelial cells results in ac
82 ype and mutant cells showed that ablation of HNF-1beta increases by 6-fold the number of sites on chr
83  This is likely to reflect reduced action of HNF-1beta in the liver and possibly the kidney.
84 of HNF1B leading to a superimposed defect of HNF-1beta transcriptional activity.
85    We conclude that the C-terminal domain of HNF-1beta is required for the activation of the Pkhd1 pr
86 arget genes responsible for the functions of HNF-1beta, however, is incompletely defined.
87  as a previously unrecognized target gene of HNF-1beta in the kidney.
88 HNF-1beta or kidney-specific inactivation of HNF-1beta decreased the expression of genes that are ess
89                              Inactivation of HNF-1beta in mouse kidney tubules leads to early-onset c
90 to mice with kidney-specific inactivation of HNF-1beta.
91                      Moreover, inhibition of HNF-1beta significantly reduced PPARGC1A expression and
92 IFN-gamma and TNF-alpha led to inhibition of HNF-1beta transcriptional activity.
93                                  Knockout of HNF-1beta in the mouse kidney results in cyst formation.
94                                 Mutations of HNF-1beta cause maturity-onset diabetes of the young, ty
95  Humans with autosomal dominant mutations of HNF-1beta develop maturity-onset diabetes of the young t
96                                 Mutations of HNF-1beta inhibited Kif12 transcription in both cultured
97                                 Mutations of HNF-1beta lead to a syndrome of inherited renal cysts an
98                                 Mutations of HNF-1beta produce congenital cystic abnormalities of the
99                                 Mutations of HNF-1beta produce congenital kidney abnormalities and in
100                                 Mutations of HNF-1beta produce cystic kidney disease, a phenotype ass
101 fy multiple mechanisms, whereby mutations of HNF-1beta produce defects in urinary concentration.
102 1 expression, which argues that mutations of HNF-1beta produce kidney cysts by down-regulating the AR
103                                 Mutations of HNF-1beta produce kidney cysts, and previous studies hav
104  expression was inhibited in the presence of HNF-1beta siRNA indicative of its involvement in ATRA-in
105   Here we show that the C-terminal region of HNF-1beta contains an activation domain that is function
106 etion is located in the pseudo-POU region of HNF-1beta, a region implicated in the specificity of DNA
107        These findings reveal a novel role of HNF-1beta in a transcriptional network that regulates in
108        These findings reveal a novel role of HNF-1beta in osmoregulation and identify multiple mechan
109            However, the complete spectrum of HNF-1beta-regulated genes and pathways is not known.
110 , is also a direct transcriptional target of HNF-1beta through binding to negative regulatory element
111 00a/429) as novel transcriptional targets of HNF-1beta.
112                                 Treatment of HNF-1beta mutant mIMCD3 cells with hypertonic NaCl inhib
113  of the homologous transcriptional regulator HNF-1beta rationalize the functional heterodimerization
114 pitation and sequencing experiments revealed HNF-1beta binding to the Nr1h4 promoter in wild-type kid
115                                  CD-specific HNF-1beta mutant mice survived long term and developed s
116              These findings demonstrate that HNF-1beta regulates canonical Wnt target genes through l
117              Pathway analysis predicted that HNF-1beta regulates cholesterol metabolism.
118                        Thus, we propose that HNF-1beta links extracellular inflammatory signals to mi
119               Pathway analysis revealed that HNF-1beta binds near 68 axon guidance genes in the devel
120                       ChIP-seq revealed that HNF-1beta binds to 8284 sites in chromatin from E14.5 mo
121                      These studies show that HNF-1beta directly regulates the expression of multiple
122 and histone modification studies showed that HNF-1beta binding peaks colocalized with open chromatin
123 the kidney, and previous studies showed that HNF-1beta regulates the expression of the autosomal rece
124  cysts, and previous studies have shown that HNF-1beta regulates the transcription of cystic disease
125 y suggest that heterozygous mutations in the HNF-1beta gene are associated with a syndrome characteri
126                             Mutations of the HNF-1beta binding sites abolished promoter activity.
127                          The sequence of the HNF-1beta gene ( TCF2 ) revealed a 75 bp deletion in exo
128  which overlapped with downregulation of the HNF-1beta transcriptional network.
129   Luciferase reporter assays showed that the HNF-1beta binding sites were located within a promoter t
130 ete for binding to this element, and thereby HNF-1beta inhibits beta-catenin-dependent transcription.
131                                        Thus, HNF-1beta regulates tubulogenesis by controlling the lev
132 ctivation of the Pkhd1 promoter by wild-type HNF-1beta is stimulated by sodium butyrate or coactivato
133 e C-terminal domain interacts with wild-type HNF-1beta, binds DNA, and functions as a dominant-negati
134 These studies reveal a novel pathway whereby HNF-1beta directly contributes to the control of miRNAs
135                          We examined whether HNF-1beta mutation carriers are insulin resistant.
136 esent in complexes throughout the day, while HNF-1beta binding exhibited circadian periodicity.
137 nal clinical features may be associated with HNF-1beta mutations.
138 in in HNF-1beta mutant cells colocalize with HNF-1beta-occupied sites in wild-type cells, indicating
139                                Subjects with HNF-1beta mutations have reduced insulin sensitivity of
140 with HNF-1alpha mutations, six subjects with HNF-1beta mutations, and six control subjects, matched f
141                                Subjects with HNF-1beta mutations, in contrast to the other transcript
142                                           WT HNF-1beta binds to two evolutionarily conserved sites lo
143                          Mechanistically, WT HNF-1beta recruits the polycomb-repressive complex 2 tha
144 s (42.7 years) than HNF-1alpha (20.4 years), HNF-1beta (24.2 years), or HNF-4alpha (26.3 years) gene

 
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