ライフサイエンスコーパス: HTS

1 HTS and FC showed similar 5-year EFS and OS for MRD-posi

2 HTS and phylogenetic analysis of paired specimens confir

3 HTS circuits operating at liquid-nitrogen temperatures (

4 HTS is expected to have a profound effect on the underst

5 HTS is the result of dysregulated wound healing, where e

6 HTS methods predominantly are based on a targeted workfl

7 HTS platforms based on radioactivity are expensive, both

8 HTS revealed that MIR1249 inhibition enhanced chemothera

9 HTS screening led to identification of five distinct sub

10 HTS-based methods can simultaneously identify multiple g

11 tant insights into defects engineering of 2G HTS coil wires.

12 This novel 3D HTS platform is fast, robust and has the potential to id

13 showing a 50-fold increase over those from a HTS (high-throughput screen).

14 We also report the results of a HTS of 216,767 compounds tested against P. aeruginosa Ds

15 CSR recombination junctions sequenced with a HTS-based protocol (Ion Torrent technology).

16 In this Letter we demonstrate all-HTS Josephson superconducting tunnel junctions created b

17 Although HTS technologies have proven their use in cataloging hum

18 An HTS campaign using an RNA-dependent ATPase assay and ini

19 An HTS endurance buffer was used for >25 000 injections wit

20 e the application of AMI-MS by developing an HTS-compatible assay that measures the inhibition of his

21 ine benzimidazole series was derived from an HTS hit and optimized by utilization of a docking model,

22 s a gatekeeper to assure assay quality in an HTS study.

23 d the performance of freezer-ready iNs in an HTS-amenable phenotypic assay that measured neurite outg

24 ients providing evidence that introducing an HTS genetic test is a valuable addition to laboratory di

25 utilizing external fluorescent probes, is an HTS compatible technique, but high protein concentration

26 The ARE-bla computational model and HTS data from a big data source (PubChem) were used to p

27 ermore, hybrid genome assembly with RTnS and HTS reads substantially improved upon a genome assembled

28 ARQiv-HTS thus enables large-scale whole-organism drug discove

29 ocess of establishing and implementing ARQiv-HTS: (i) assay design and optimization, (ii) calculation

30 col for a recently completed inaugural ARQiv-HTS effort, which involved the identification of compoun

31 strategies for leveraging the power of ARQiv-HTS for zebrafish-based drug discovery, and address tech

32 th customized robotics, and is termed 'ARQiv-HTS'.

33 ond this initial example, however, the ARQiv-HTS platform is adaptable to almost any reporter-based a

34 lex 3D cell environment in a fully automated HTS workflow.

35 s can import their own or publicly available HTS data into LabxDB seq to manage them from production

36 equent hitters" using 872 publicly available HTS data sets.

37 The cell-based HTS allowed us to identify an anti-cancer drug of bis-bi

38 Overall, our FRET-based HTS platform sets the stage to screen large compound lib

39 fication strategy that enables nESI-MS based HTS assays in 96-well microtiter plates.

40 We describe an MS-based HTS workflow that addresses these challenges.

41 ymorphisms (SNPs) with severity of post-burn HTS, we conducted a prospective cohort study of burned a

42 ting two unique scaffolds were discovered by HTS and disrupt surface protein display in intact cells

43 th day 29 MRD <0.1% by FC) were evaluated by HTS and FC for event-free (EFS) and overall survival (OS

44 ands predicted in silico as well as found by HTS, were identified.

45 Of the 167 ligands identified by HTS, five were predicted to potentially cause clinical d

46 t caution when interpreting data obtained by HTS of these remains.

47 hile providing evidence for a robust in-cell HTS platform that can be adapted to search for any chann

48 Combined HTS (11000 compounds) and in-house screening of a limite

49 We next conducted HTS of ~23,000 compounds but found no positive hits.

50 Conventional HTS platforms require expensive reagents and typically h

51 A repository of curated HTS training materials would support trainers in materia

52 cells in psoriasis, we carried out TCR/delta HTS.

53 tool compound, swinholide A, we demonstrate HTS compatibility with an excellent Z'-factor of 0.67 +/

54 In a differential HTS analysis including the human AChE, several structura

55 g HTS etiology and developing more effective HTS therapies.

56 role of CSMD1 in wound healing may elucidate HTS pathophysiology.

57 en in vivo, which is critical to elucidating HTS etiology and developing more effective HTS therapies

58 may be easily developed for certain enzymes, HTS assays designed to identify ligands that block prote

59 1 month after device removal; an excisional HTS model was also imaged at 6 months after injury to in

60 n-based high-temperature superconductors (Fe-HTSs) is non-universal.

61 er unconventional superconductors, in the Fe-HTSs both d-wave and extended s-wave pairing symmetries

62 This represents the first HTS for sortase inhibitors that relies on the simple met

63 polarization provide a robust signature for HTS.

64 e to develop a cell-based assay suitable for HTS to rapidly identify inhibitors arenavirus multiplica

65 Our FP-HTS identified eight inhibitors that blocked the MDM2 pr

66 ification of singleton P2X7 inhibitor 1 from HTS gave a pharmacophore that eventually turned into pot

67 tially improved upon a genome assembled from HTS reads alone.

68 The racemic screening hit from HTS campaign 11a was discovered with an enzymatic IC(50)

69 The hits from HTS were further screened for their AChE inhibitory acti

70 as a powerful tool to triage drug-leads from HTS for formal efficacy testing in mice.

71 n to construct the annotated mitogenome from HTS raw data and will facilitate large scale ecological

72 th annotation and visualization results from HTS raw reads.

73 sha (preprocessing of aligned sequences from HTS analyses) allows easy manipulation of aligned reads

74 Optimization of this series from HTS was supported by a GLP-1R ligand binding model.

75 Starting from HTS hit 5, IDO-1 inhibitor 6 (EOS200271/PF-06840003) has

76 The mechanisms guiding HTS formation are multifactorial and complex.

77 Herein, we review how HTS has led to the discovery of novel nucleic acid speci

78 llance time points before relapse, plasma Ig-HTS demonstrated improved specificity (100% vs 56%, P <

79 mmunoglobulin high-throughput sequencing (Ig-HTS) from peripheral blood provides an alternate strateg

80 Given its high specificity, Ig-HTS from plasma has potential clinical utility for surve

81 To better understand compound behavior in HTS, we assessed an existing binomial survivor function

82 rrect position-specific nucleotide biases in HTS short read data.

83 al structure and thus increase confidence in HTS data by decreasing false positive testing results.

84 These biases are particularly evident in HTS assays for identifying regulatory regions in DNA (DN

85 airway neurons and epithelia are involved in HTS treatment-triggered ASL secretion in CFTR(-/-) and w

86 of the z-factor for quality control (QC) in HTS studies.

87 centrations and their activities reported in HTS assays, we developed a probabilistic model for estim

88 tedly high demand for training scientists in HTS data analysis.

89 ross-contamination was highly significant in HTS.

90 trength limitation of our earlier innovative HTS shim concept based on 46-mm wide REBCO tape.

91 to gain significant biological insights into HTS remodeling by enabling longitudinal assessment of co

92 Optimization of KDM6B (JMJD3) HTS hit 12 led to the identification of 3-((furan-2-ylme

93 Using the DSD, large HTS data sets can be modelled in many cases as two distr

94 fferent laboratories, presenting the largest HTS assessment of charred archaeobotanical specimens to

95 resolution NMR magnet composed of an 835-MHz HTS insert, while another version for an MIT 1-GHz micro

96 A mini-HTS on 4000 compounds selected using 2D fragment-based s

97 Most HTS magnets made so far have been made out of REBCO coat

98 Most HTS platforms use fluorescence and luminescence technolo

99 9 different end points using two multiplexed HTS assays.

100 assessment of collagen remodeling in murine HTS.

101 er, storage and transfer of large amounts of HTS data present a significant challenge.

102 re available, either for general analysis of HTS data or targeted to a specific sequencing technology

103 represents a next step in the QC analysis of HTS data.

104 Application of HTS revealed the presence of a more diverse fungal commu

105 Application of HTS techniques has led to many key discoveries, includin

106 to enable more complete characterizations of HTS chemical matter.

107 Therefore, the collapse of HTS with overdoping is not caused by competing ferromagn

108 an alternative explanation - competition of HTS with ferromagnetic order, fluctuating in superconduc

109 nd antioxidants impinge on the complexity of HTS-induced responses over different genetic backgrounds

110 end on race, but the genetic determinants of HTS are unknown.

111 resulted in ~50% reduction of the effect of HTS treatment on ASL volume in vivo.

112 s an up-to-date overview of the evolution of HTS and the accompanying tools, infrastructure and data

113 Here we report the findings of HTS and target enrichment on four important archaeologic

114 Worldwide growth of HTS data has prompted the development of compression met

115 In the first published GWAS of HTS, we report that a common intronic variant in the CSM

116 The management of HTS has been challenging for clinicians, since current t

117 tunities in the prevention and management of HTS.

118 ng-site preference for the growing number of HTS-based epigenetic assays.

119 sensitivity and lower false-negative rate of HTS improves upon FC for MRD detection in pediatric B-AL

120 th a focus on the current and future role of HTS-based assays.

121 ition, the increased analytic sensitivity of HTS permitted identification of 19.9% of SR patients wit

122 ompression methods on a comprehensive set of HTS data using an automated framework.

123 A subset of HTS data contains a large number of sample measurements

124 rategy that can be used to improve uptake of HTS among children and adolescents.

125 f the nervous system and airway epithelia on HTS-stimulated ASL height increase in CF and wild-type s

126 rate tool for analysis of sequences from our HTS-based protocol for CSR junctions, thereby facilitati

127 retardation and low degree of polarization, HTS was characterized by an initially low local retardat

128 associated with reduced severity of postburn HTS.

129 Risk of severe postburn HTS is known to depend on race, but the genetic determin

130 From a modestly potent HTS hit (4), we identified molecules such as 6-[6-(metho

131 Here, benzamide analogues based on previous HTS hits have been purchased or synthesized.

132 catalyzed peptide hydrolysis, a prototypical HTS assay of relevance to drug discovery.

133 nd genome coverage can be used to reconsider HTS data storage strategies.

134 ion methods that aim to significantly reduce HTS data size.

135 Most reported HTS QC metrics are designed for plate level or single we

136 This rigorous HTS approach eliminates promiscuous candidate leads, sig

137 Inhaled hypertonic saline (HTS) treatment is used to improve lung health in patient

138 Here, we present a scalable, HTS-compatible workflow for the automated generation, ma

139 selectivity is advantageous for large-scale HTS campaigns and as anticipated based on assay design b

140 Hypertrophic scar (HTS) formation is a frequent postoperative complication

141 rminants of post-burn hypertrophic scarring (HTS) are unknown, and melanocortin 1 receptor (MC1R) los

142 Hypertrophic scars (HTS), frequently seen after traumatic injuries and surge

143 ing a high-throughput small-molecule screen (HTS), we find that analogs of the small molecule harmine

144 ain to a large-scale high-throughput screen (HTS) drug discovery campaign, allowing multicycle infect

145 ssay, we performed a high-throughput screen (HTS) for small molecules capable of relieving utrophin p

146 We have conducted a high throughput screen (HTS) of 17,500 compounds for inhibition of the essential

147 In a high throughput screen (HTS) of 230000 small molecules designed to identify bioa

148 sually begins with a high-throughput screen (HTS) of thousands to millions of molecules to identify s

149 ulfhydryl-scavenging high-throughput screen (HTS) targeting the histone acetyltransferase Rtt109 were

150 oped a dual-reporter high-throughput screen (HTS) that reduced the rate of nonspecific and promiscuou

151 ls, we carried out a high throughput screen (HTS) using an ApoC-III homogenous time resolved fluoresc

152 A high-throughput screen (HTS) was undertaken against the respiratory chain dehydr

153 ped a small-molecule high-throughput screen (HTS) with human renal cells having an integrated lucifer

154 A high-throughput screen (HTS), using an assay of Ca(2+)-induced mitochondrial swe

155 platform for high-throughput drug screening (HTS).

156 Demonstrating the high-throughput screening (HTS) adaptability, the gamma9 assay performed using an i

157 FB inhibitors by high-throughput screening (HTS) and leveraging insights from several X-ray cocrysta

158 s and amenable to high-throughput screening (HTS) applications.

159 re, we validate a high-throughput screening (HTS) assay to discover potential disrupters of the inter

160 d host cell-based high throughput screening (HTS) assay to screen and characterize FDA-approved, off-

161 ely by a chemical high-throughput screening (HTS) assay.

162 However, most high throughput screening (HTS) assays for drug discovery use cancer cells grown in

163 consortium in 971 high-throughput screening (HTS) assays whose targets were mapped onto human organs

164 High throughput screening (HTS) assesses compound libraries for "activity" using ta

165 een developed for high-throughput screening (HTS) bioassays.

166 ming a cell-based high throughput screening (HTS) campaign, we identified several potential small mol

167 MPK) analysis and high-throughput screening (HTS) campaigns, two stress tests were performed regardin

168 can achieve true high-throughput screening (HTS) capacities.

169 ces quantitative, high-throughput screening (HTS) data on thousands of chemicals across a wide range

170 lyses translating high-throughput screening (HTS) data to human relevance have been limited.

171 New sources of high-throughput screening (HTS) data, such as the ToxCast database, which contains

172 Large high-throughput screening (HTS) efforts are widely used in drug development and che

173 quinoline hit via high throughput screening (HTS) followed by optimization provided a 4-phenyl-3-aryl

174 High-throughput screening (HTS) has enabled millions of compounds to be assessed fo

175 l optimization of high-throughput screening (HTS) hit 1 led to the identification of 3, which demonst

176 t emanated from a high throughput screening (HTS) hit and progressed via iterative cycles of structur

177 an indazole amide high throughput screening (HTS) hit followed by truncation to its minimal pharmacop

178 Starting from a high-throughput screening (HTS) hit of our corporate compound library, multiple par

179 from a phenotypic high-throughput screening (HTS) hit with suboptimal physicochemical properties.

180 ng of biochemical high-throughput screening (HTS) hits led to the discovery of a series of ligands th

181 around one of the high-throughput screening (HTS) hits, N(2)-(thiophen-3-yl)-N(6)-(2,2,2-trifluoroeth

182 g addressed using high-throughput screening (HTS) in vitro approaches and computational modeling.

183 tudy, we utilized high-throughput screening (HTS) in vitro data of PAHs to predict health risks assoc

184 High throughput screening (HTS) interrogates compound libraries to find those that

185 High throughput screening (HTS) is a vital automation technology in biomedical rese

186 sent a risk-based high-throughput screening (HTS) method to identify chemicals for potential health c

187 eloping effective high-throughput screening (HTS) methods is of paramount importance in the early sta

188 urrent cell-based high-throughput screening (HTS) models to identify molecules affecting ECM accumula

189 then conducted a high-throughput screening (HTS) of 267 FDA-approved compounds targeting known media

190 a small-molecule high-throughput screening (HTS) of 68, 979 compounds and identified nine compounds

191 High-throughput screening (HTS) of 997 locked nucleic acid miRNA inhibitors was per

192 We performed high-throughput screening (HTS) of a chemical library to identify binders of mircoR

193 ctional assay for high-throughput screening (HTS) of autoprocessing inhibitors using fusion precursor

194 on (FP) assay for high-throughput screening (HTS) of chemical libraries.

195 s suitability for high-throughput screening (HTS) of PPI inhibitors.

196 Utilizing high-throughput screening (HTS) of the T cell receptor (TCR) and immunostaining, we

197 In this study, a high-throughput screening (HTS) platform integrating optical fluorescence detectors

198 s are critical in high throughput screening (HTS) platforms to ensure reliability and confidence in a

199 ncy (EPA) ToxCast high-throughput screening (HTS) program.

200 High-throughput screening (HTS) research programs for drug development or chemical

201 icular cell-based high-throughput screening (HTS) studies, have provided the research community with

202 High-throughput screening (HTS) technologies have greatly increased the number of b

203 In parallel, high-throughput screening (HTS) was conducted using the fluorescent probe substrate

204 caling of iNs for high throughput screening (HTS)-ready assays.

205 entified out of a high-throughput screening (HTS).

206 whole-cell-based high-throughput screening (HTS).

207 of the success of high-throughput screening (HTS).

208 sed on a hit from high-throughput screening (HTS).

209 rhagic fever, for high-throughput screening (HTS).

210 ibraries used for high-throughput screening (HTS).

211 ust phenotype for high throughput screening (HTS).

212 etamide 1 through high-throughput screening (HTS).

213 vitro (including high-throughput screening [HTS]), in vivo, and ex vivo, we developed a highly sensi

214 for using IAV in high-throughput screenings (HTS) to identify novel antivirals that can be incorporat

215 y is unsuitable for high throughput screens (HTS), we developed a novel method using 3D growth in ult

216 ologically relevant high-throughput screens (HTS).

217 in both screens were confirmed in secondary HTS and low-throughput assays.

218 High-throughput sequence (HTS) data exhibit position-specific nucleotide biases th

219 High throughput DNA sequencing (HTS) technologies generate an excessive number of small

220 High-throughput sequencing (HTS) and bioinformatics have expanded our understanding

221 High-throughput sequencing (HTS) data are commonly stored as raw sequencing reads in

222 e for processing high-throughput sequencing (HTS) data.

223 also developed a high-throughput sequencing (HTS) database, LabxDB seq, dedicated to storage of hiera

224 While high-throughput sequencing (HTS) has been used successfully to discover tumor-specif

225 accessibility of high-throughput sequencing (HTS) has transformed this study, enabling large-scale en

226 capabilities of high throughput sequencing (HTS) instruments have exponentially increased over the l

227 High-throughput sequencing (HTS) is now a widely used and accessible technology that

228 laboratory-based high-throughput sequencing (HTS) methods for species level identification and phylog

229 Here, we compare high-throughput sequencing (HTS) of IGH and TRG genes vs flow cytometry (FC) for mea

230 High-throughput sequencing (HTS) of in vitro selected populations offers a large sca

231 nt tissues using high-throughput sequencing (HTS) of the gene encoding the T cell receptor (TCR) beta

232 ruses.IMPORTANCE High-throughput sequencing (HTS) of virus-infected cells can be used to study in gre

233 have shifted to High-Throughput Sequencing (HTS) or Next-Generation Sequencing (NGS) technologies, s

234 A targeted high-throughput sequencing (HTS) panel test for clinical diagnostics requires carefu

235 High-throughput sequencing (HTS) provides opportunities for investigation of AMR acr

236 e advancement of high-throughput sequencing (HTS) technologies and the rapid development of numerous

237 n suggested that high-throughput sequencing (HTS) technologies coupled with DNA enrichment techniques

238 ith the onset of High Throughput Sequencing (HTS) technologies.

239 al repertoire by high throughput sequencing (HTS) technology.

240 e application of high throughput sequencing (HTS) to large collections of human genomes.

241 have developed a high-throughput sequencing (HTS) workflow for investigating paramyxovirus transcript

242 In the era of high-throughput sequencing (HTS), computational considerations, data governance and

243 nces produced by high-throughput sequencing (HTS), we designed CSReport, a software program dedicated

244 By high throughput sequencing (HTS), we obtained the first de novo transcriptome of mah

245 available tests, high-throughput sequencing (HTS)-based approaches are increasingly attractive for no

246 confirmed using high-throughput sequencing (HTS).

247 arcoding through high throughput sequencing (HTS).

248 The prevalence of severe HTS (VSS>7) was 49%, and the mean itch score was 3.9.

249 Testing for association with severe HTS (VSS>7) and itch severity (0-10) was based on multiv

250 gnificantly (P<0.001) associated with severe HTS.

251 ce were independently associated with severe HTS.

252 its utility in multiple CRISPR/CAS9 or siRNA HTS studies.

253 Applying the DSD to some HTS data sets revealed signs of bias in some of the data

254 .0, in a scintillation proximity assay (SPA) HTS at a lower hit rate and with a significantly reduced

255 igh-throughput screening Raman spectroscope (HTS-RS), Raman spectra of more than 2000 individual neut

256 wheat cultivars to high temperature stress (HTS).

257 In this study, HTS was induced with a mechanical tension device for 4-1

258 s of novel high-temperature superconducting (HTS) shim coil prototypes that circumvent the size and s

259 hat show high-temperature superconductivity (HTS), the critical temperature (Tc) has a dome-shaped do

260 ements on a high temperature superconductor (HTS), a (Rare-Earth)Ba(2)Cu(3)O(7-delta) (REBCO) coated

261 High-temperature superconductors (HTS) could enable high-field magnets stronger than is po

262 scovery of high-temperature superconductors (HTSs), most efforts of researchers have been focused on

263 high-transition-temperature superconductors (HTSs), researchers have explored many methods to fabrica

264 Another challenge of targeted HTS is the risk of specimen-to-specimen cross-contaminat

265 However, there is evidence that HTS may also stimulate active secretion of ASL by airway

266 Our results indicated that HTS-triggered ASL secretion is partially mediated by the

267 The HTS identified PanK inhibitors exemplified by the detail

268 The HTS resulted in the identification of four candidate com

269 The HTS shim coil is placed inside the HTS magnet, mainly fo

270 the sharing of teaching experience among the HTS trainers' community.

271 The 11000 compounds were selected for the HTS based on the known phenothiazine Ndh inhibitors, tri

272 k) is markedly B, (field angle theta for the HTS) and T dependent in both materials.

273 Dose-response assays with 1 from the HTS sample, as well as commercial material, yielded simi

274 nique chemicals with curated activity in the HTS data using high-quality dose-response model fits and

275 atistically grounded criterion for QC in the HTS studies.

276 The HTS shim coil is placed inside the HTS magnet, mainly for ultra-high-field (> 1 GHz or 23.5

277 idine series was the moderate potency of the HTS hits.

278 enza A/H3N2 samples were sequenced using the HTS protocol and were compared against a Sanger-based se

279 o help assess the predictive utility of this HTS platform.

280 396 index patients using the ThromboGenomics HTS panel test of diagnostic-grade genes known to harbor

281 f the previously identified high-throughput (HTS) hit 1 (ESI-09).

282 This CarD FP assay is amenable to HTS and is an enabling tool for future novel therapeutic

283 Although applied here to HTS, it is applicable to data sets with a large number o

284 ubstantially decreased secretory response to HTS treatment after blockage of neuronal activity.

285 ross airway decreased secretory responses to HTS treatment.

286 ehensive activity summaries across all Tox21 HTS assay targets provide an overall picture of chemical

287 a combined data set of 11 ToxCast(TM)/Tox21 HTS in vitro assays.

288 We used the extensive ToxCast HTS binding data set to show that OASIS ER and AR QSAR m

289 This transformation HTS identified picropodophyllin, an insulin growth facto

290 he goal to identify MPS1 inhibitors were two HTS hits from the distinct chemical series "triazolopyri

291 he next generation of ultra-high-field (UHF) HTS NMR magnets.

292 A significant obstacle to understanding HTS etiology is the lack of tools to monitor scar remode

293 To make multiple uniform HTS junctions, control at the atomic level is required.

294 s for virtually any tyrosine kinase that use HTS-compatible lanthanide-based detection.

295 Using HTS data from a variety of ChIP-seq, DNase-seq, FAIRE-se

296 ults underscore the feasibility of utilizing HTS to identify compounds that mimic key downstream even

297 onclusion, by combining docking and in vitro HTS, competitive and noncompetitive ligands of OCT1 can

298 ed into a reliable 384- and 1,536-multi-well HTS assay that reproduces the human ovarian cancer (OvCa

299 ed analysis of chemical occurrence data with HTS data offers new opportunities to prioritize chemical

300 wever, there was a high discordant rate with HTS identifying 55 (38.7%) more patients MRD positive at