ライフサイエンスコーパス: Histoplasma

1 of infected mice, which contain all visible Histoplasma.

2 critically required for the host response to Histoplasma.

3 jor mechanism by which human DC mediate anti-Histoplasma activity is through the exposure of yeasts t

4 f the vacuolar ATPase, did not block DC anti-Histoplasma activity, indicating that phagosome acidific

5 ith microbial antigens (e.g., leishmania and histoplasma Ags) were capable of inducing proliferative

6 Histoplasma and Blastomyces antigen detection assays are

7 Most of the Histoplasma and most of the apoptotic cells are found in

8 ecific genes that may influence virulence in Histoplasma and other dimorphic fungal pathogens.

9 ida, Aspergillus, Exserohilum, Cryptococcus, Histoplasma, and Coccidioides, were studied, although mo

10 virus, enterovirus, Brucella, Coccidioides, Histoplasma, and mycobacteria, were negative.

11 The MVista Histoplasma antibody EIA offers increased sensitivity ov

12 ry histoplasmosis and controls in the MVista Histoplasma antibody EIA.

13 greement (64.5%) with the MiraVista (MVista) Histoplasma antigen (Ag) quantitative EIA (MiraVista Dia

14 On hospital day 11, results of his CSF Histoplasma antigen and urine antigen tests were positiv

15 Histoplasma capsulatum endocarditis in which Histoplasma antigen assay and fungal blood cultures were

16 body-based in vitro diagnostic (IVD) kit for histoplasma antigen detection was released, as well as m

17 Urine Histoplasma antigen detection was the most sensitive dia

18 of cross-reactivity between Blastomyces and Histoplasma antigen EIAs, utilization of a single antige

19 The Histoplasma antigen immunoassay utilizes an antibody san

20 ked immunoassay (EIA) for the measurement of Histoplasma antigen in banked urine specimens.

21 Both assays were capable of detecting histoplasma antigen in urine samples over a wide dynamic

22 multiple assays are available for measuring histoplasma antigen in urine, a monoclonal-antibody-base

23 interval {CI}, 1.06-14.60]) and higher urine Histoplasma antigen levels (OR, 1.14 [95% CI, 1.03-1.25]

24 eptable alternative to the RIA for measuring Histoplasma antigen levels in urine specimens.

25 Urinary histoplasma antigen measurement can be useful for diagno

26 istoplasmosis antibody test (n = 349 [18%]), Histoplasma antigen test (n = 349 [18%]), fungal smear (

27 Microplates coated with Histoplasma antigen were used for testing of serum from

28 luding cryptococcus capsular polysaccharide, histoplasma antigen, galactomannan, and beta-d-glucan, i

29 ning, and lactic acid, cryptococcal antigen, histoplasma antigen, herpes simplex virus polymerase cha

30 BG results for the 10 Histoplasma antigen-negative and the 32 Aspergillus gala

31 All six Histoplasma antigen-positive patients and 31 of 32 Asper

32 been tested for Aspergillus galactomannan or Histoplasma antigen.

33 nificant polyfunctional cytokine response to histoplasma antigen.

34 hin the 48-week follow-up, the prevalence of Histoplasma antigenuria was 15/42 (35.7%% 95% CI: 22.0%-

35 d no detectable reaction with Blastomyces of Histoplasma antiserum by ID.

36 ity with a respiratory isolate thought to be Histoplasma but not morphologically consistent with H. c

37 ased system for silencing gene expression in Histoplasma by RNA interference (RNAi).

38 Infections with Histoplasma can range from asymptomatic to life-threaten

39 Ten cases of Histoplasma capsulatum (HC) infection were reported: 9 a

40 Histoplasma capsulatum (Hc) is a facultative intracellul

41 Histoplasma capsulatum (Hc) is a facultative intracellul

42 Histoplasma capsulatum (Hc) is a facultative, intracellu

43 Histoplasma capsulatum (Hc) is a pathogenic fungus that

44 rimary and secondary infection by the fungus Histoplasma capsulatum (HC) is multifactorial, requiring

45 Histoplasma capsulatum (Hc) maintains a phagosomal pH of

46 The intracellular fungal pathogen Histoplasma capsulatum (Hc) resides in mammalian macroph

47 genic fungi Cryptococcus neoformans (CN) and Histoplasma capsulatum (HC) to external gamma-radiation

48 ix proteins, and the intracellular growth of Histoplasma capsulatum (Hc) yeasts were quantified and c

49 e deficient in their capacity to phagocytose Histoplasma capsulatum (Hc) yeasts, and are more permiss

50 Histoplasma capsulatum (Hc), is a facultative intracellu

51 r host defense against the pathogenic fungus Histoplasma capsulatum (Hc).

52 imary and secondary pulmonary infection with Histoplasma capsulatum (Hc).

53 ), Cryptococcus neoformans (cryptococcosis), Histoplasma capsulatum (histoplasmosis), and Talaromyces

54 statistically significantly more isolates of Histoplasma capsulatum (P = 0.004), but all of these iso

55 A monoclonal antibody (MAb) raised against a Histoplasma capsulatum 80-kDa hsp showed cross-reactivit

56 dermatitidis an extracellular pathogen, and Histoplasma capsulatum a facultative intracellular patho

57 We describe a case in which the Histoplasma capsulatum AccuProbe test displayed cross-re

58 We demonstrated the ability of the Histoplasma capsulatum AccuProbe to accurately identify

59 ffers from the epitopes that are shared with Histoplasma capsulatum and Blastomyces dermatitidis.

60 it exerts potent antifungal activity against Histoplasma capsulatum and Cryptococcus neoformans by di

61 f microarrays built with genomic elements of Histoplasma capsulatum and ESTs of Paracoccidioides bras

62 oplasmosis; it has in-vitro activity against Histoplasma capsulatum and has shown success in case rep

63 ular evidence suggests a direct link between Histoplasma capsulatum and presumed ocular histoplasmosi

64 nsformation system for the pathogenic fungus Histoplasma capsulatum and used it to examine the effect

65 egative for C. immitis, B. dermatitidis, and Histoplasma capsulatum antibodies.

66 Paracoccidioides brasiliensis and Histoplasma capsulatum are ancestral to most Emmonsia is

67 Blastomyces dermatitidis and Histoplasma capsulatum are dimorphic fungi that often ca

68 Improved methods for the detection of Histoplasma capsulatum are needed in regions with limite

69 The success of Histoplasma capsulatum as an intracellular pathogen depe

70 nction of HIF-1alpha in the host response to Histoplasma capsulatum because granulomas induced by thi

71 Histoplasma capsulatum can efficiently survive within ma

72 The fungal pathogen Histoplasma capsulatum causes a spectrum of disease, ran

73 molecular cloning and characterization of a Histoplasma capsulatum cDNA (GH17) that encodes an antig

74 esented with a Mycobacterium haemophilum and Histoplasma capsulatum coinfection occurring 21 years af

75 ported that immunization with H antigen from Histoplasma capsulatum did not protect mice against an i

76 The fungus Histoplasma capsulatum displays an Hsp60 on its cell sur

77 dentified a secreted proteolytic activity in Histoplasma capsulatum effective toward DppIV-specific s

78 The YPS3 gene of Histoplasma capsulatum encodes a protein that is both su

79 We report a case of Histoplasma capsulatum endocarditis in which Histoplasma

80 The pathogenic fungus Histoplasma capsulatum escapes innate immune defenses an

81 The fungal pathogen Histoplasma capsulatum evades the innate and adaptive im

82 1990 through 1994, we fortuitously isolated Histoplasma capsulatum from six patients with AIDS whose

83 regulatory T cells (Tregs) using a model of Histoplasma capsulatum fungal infection.

84 library representing 10-fold coverage of the Histoplasma capsulatum G217B genome was used to construc

85 Here, we detail mapping the Histoplasma capsulatum genome comprehensively in fosmids

86 The human fungal pathogen Histoplasma capsulatum grows in a sporulating filamentou

87 The Histoplasma capsulatum H antigen is a major secreted gly

88 ponse to the intracellular pathogenic fungus Histoplasma capsulatum has increased dramatically.

89 Histoplasma capsulatum has not typically been associated

90 human fungal pathogens Candida albicans and Histoplasma capsulatum have been reported to protect aga

91 A real-time PCR assay to detect Histoplasma capsulatum in formalin-fixed, paraffin-embed

92 e examined the immunobiological responses to Histoplasma capsulatum in lungs of gamma interferon (IFN

93 n-4 impairs clearance of the fungal pathogen Histoplasma capsulatum in mice lacking the chemokine rec

94 Histoplasma capsulatum induces a cell-mediated immune re

95 Histoplasma capsulatum induces a cell-mediated immune re

96 tion with heat shock protein 60 (Hsp60) from Histoplasma capsulatum induces a protective immune respo

97 Rising rates of Histoplasma capsulatum infection are an emerging problem

98 emonstrate that CCR5 controls the outcome of Histoplasma capsulatum infection by dictating thymic and

99 mmalian host specifically limits iron during Histoplasma capsulatum infection, and fungal acquisition

100 B6C3F(1) mice were infected by injection of Histoplasma capsulatum into the subarachnoid space.

101 Histoplasma capsulatum is a dimorphic fungal pathogen th

102 Histoplasma capsulatum is a dimorphic fungus that causes

103 Histoplasma capsulatum is a dimorphic fungus that is end

104 Histoplasma capsulatum is a fungal pathogen that causes

105 Histoplasma capsulatum is a fungal pathogen that require

106 Histoplasma capsulatum is a fungal respiratory pathogen

107 Histoplasma capsulatum is a pathogenic fungus that exist

108 Histoplasma capsulatum is a pathogenic fungus with two d

109 Histoplasma capsulatum is a respiratory pathogen that in

110 Histoplasma capsulatum is a significant respiratory and

111 Histoplasma capsulatum is a successful intracellular pat

112 Histoplasma capsulatum is an effective intracellular par

113 Histoplasma capsulatum is an infrequent but serious caus

114 cell-depleted mice infected with the fungus Histoplasma capsulatum is associated with impairment of

115 A fundamental feature of the fungal pathogen Histoplasma capsulatum is its ability to shift from a my

116 Histoplasma capsulatum is the best-studied of the primar

117 the pathogenesis of the respiratory pathogen Histoplasma capsulatum is the conversion from the mold f

118 Histoplasma capsulatum is the most common cause of funga

119 Histoplasma capsulatum is the most common endemic mycosi

120 The yeast phase of Histoplasma capsulatum is the virulent form of this ther

121 The phylogeny of 46 geographically diverse Histoplasma capsulatum isolates representing the three v

122 Although more Histoplasma capsulatum isolates were recovered from Plus

123 ients with deficient cell-mediated immunity, Histoplasma capsulatum may disseminate throughout the bo

124 uconazole (Flu) and amphotericin B (AmB) for Histoplasma capsulatum meningitis, MICs were determined

125 The fungal pathogen Histoplasma capsulatum minimizes detection of beta-gluca

126 ronment in which the primary fungal pathogen Histoplasma capsulatum multiplies and disseminates from

127 Primary infection to Histoplasma capsulatum often results in a self-limited u

128 tion of mice with heat shock protein 60 from Histoplasma capsulatum or a polypeptide from the protein

129 ombinant heat shock protein 60 (rHsp60) from Histoplasma capsulatum or a region of the protein design

130 Host defenses against Histoplasma capsulatum require the action of several cyt

131 The pathogenic fungus Histoplasma capsulatum requires iron for its survival du

132 Protection against the pathogenic fungus Histoplasma capsulatum requires Th1 cytokines.

133 Infection with Histoplasma capsulatum results in a subclinical infectio

134 Histoplasma capsulatum should be considered in the diffe

135 ct several general DNA binding proteins from Histoplasma capsulatum strain G217B.

136 , yps-3, has been identified in the virulent Histoplasma capsulatum strain, G217B.

137 repared from a representative North American Histoplasma capsulatum strain.

138 Many Histoplasma capsulatum strains have alpha-(1,3)-glucan i

139 Many Histoplasma capsulatum strains spontaneously give rise t

140 FM) is a rare complication of infection with Histoplasma capsulatum that can lead to obstruction of p

141 are consequence of infection with the fungus Histoplasma capsulatum that can lead to occlusion of lar

142 tested a real-time LightCycler PCR assay for Histoplasma capsulatum that correctly identified the 34

143 xpressed the gene encoding this protein from Histoplasma capsulatum to study its immunological activi

144 We cloned the Histoplasma capsulatum URA5 gene (URA5Hc) by using a pro

145 The Histoplasma capsulatum URA5 gene, which has recently bee

146 Detection of the Histoplasma capsulatum urinary antigen (UAg) is among th

147 be of limited use, whereas the detection of Histoplasma capsulatum var. capsulatum antigens may prov

148 We studied an aberrant culture of Histoplasma capsulatum var. capsulatum isolated from syn

149 ther the thermally dimorphic fungal pathogen Histoplasma capsulatum var. capsulatum produced melanin

150 Histoplasmosis caused by Histoplasma capsulatum var. duboisii (Hcd) is a rare, bu

151 Histoplasma capsulatum var. farciminosum, the causative

152 A sample of 30 clinical isolates of Histoplasma capsulatum was analyzed to determine (i) whe

153 nd ploidy of the dimorphic pathogenic fungus Histoplasma capsulatum was determined by using DNA renat

154 e H antigen of the dimorphic fungal pathogen Histoplasma capsulatum was first described over 40 years

155 )-alpha after intranasal exposure of mice to Histoplasma capsulatum was necessary for control of prim

156 yces dermatitidis, Sporothrix schenckii, and Histoplasma capsulatum were each ingested by amoebae and

157 ITS) regions of rRNA genes of 24 isolates of Histoplasma capsulatum were examined.

158 Two isolates of Histoplasma capsulatum were recovered from the Isolator

159 t (Y) phase of the dimorphic fungal pathogen Histoplasma capsulatum which are transcriptionally silen

160 ts with disseminated Coccidioides immitis or Histoplasma capsulatum with heterozygous missense mutati

161 can is present in the outermost layer of the Histoplasma capsulatum yeast cell wall and contributes t

162 potent and long-lasting fungistasis against Histoplasma capsulatum yeasts and that all of the fungis

163 During infection of the mammalian host, Histoplasma capsulatum yeasts survive and reside within

164 bility to bind calcium and its prevalence as Histoplasma capsulatum's most abundant secreted protein.

165 h chitin, in patterns ranging from circular (Histoplasma capsulatum) to punctate (Cryptococcus neofor

166 Histoplasma capsulatum, a fungal pathogen of humans, swi

167 D-1 in a mouse model of acute infection with Histoplasma capsulatum, a major human pathogenic fungus.

168 CBP is the most abundant protein secreted by Histoplasma capsulatum, a pathogenic fungus that causes

169 nt Candida species, Cryptococcus neoformans, Histoplasma capsulatum, and Blastomyces dermatitidis fro

170 ns in North America (Coccidioides posadasii, Histoplasma capsulatum, and Blastomyces dermatitidis), h

171 For the fungus Histoplasma capsulatum, and for other microbial pathogen

172 DCs) with Leishmania donovani promastigotes, Histoplasma capsulatum, and Mycobacterium kansasii impai

173 Rhizopus arrhizus, Blastomyces dermatitidis, Histoplasma capsulatum, and Sporothrix schenckii.

174 s in the lungs of C57BL/6 mice infected with Histoplasma capsulatum, and the elimination of these cel

175 rmally dimorphic fungal pathogens, including Histoplasma capsulatum, are soil fungi that undergo dram

176 fungi, including the subject of this study, Histoplasma capsulatum, are temperature-responsive organ

177 ribosomal DNA, were used to amplify DNA from Histoplasma capsulatum, Blastomyces dermatitidis, Coccid

178 r to a triglycosyl IPC (Hc-VI) reported from Histoplasma capsulatum, but differing in the anomeric co

179 nses against intracellular pathogens such as Histoplasma capsulatum, but its mode of action remains e

180 Except with Histoplasma capsulatum, chocolate agar incubated for onl

181 y significant episodes, the isolated fungus (Histoplasma capsulatum, Coccidioides immitis/posadasii,

182 The endemic fungi Histoplasma capsulatum, Coccidioides spp, Blastomyces de

183 In other fungi, such as Histoplasma capsulatum, however, more efficient gene dis

184 The zoopathogenic fungus Histoplasma capsulatum, like other eukaryotic aerobic mi

185 ve with IS only (three Candida albicans, one Histoplasma capsulatum, one Candida glabrata, and one Fu

186 ntiana, Fusarium oxysporum, Fusarium solani, Histoplasma capsulatum, Phialophora spp., Pseudallescher

187 sis, a systemic mycosis caused by the fungus Histoplasma capsulatum, primarily affects immune-suppres

188 The fungus, Histoplasma capsulatum, produces a persistent infection.

189 parasite of macrophages, the yeast phase of Histoplasma capsulatum, survives and proliferates within

190 For the dimorphic fungal pathogen Histoplasma capsulatum, susceptibility to echinocandins

191 ermatitidis, the agent of blastomycosis, and Histoplasma capsulatum, the agent of histoplasmosis, are

192 irulence mutants of Francisella novicida and Histoplasma capsulatum, we confirmed the applicability o

193 esii; and a more diverged pathogenic fungus, Histoplasma capsulatum, were sequenced and compared with

194 tigated whether Blastomyces dermatitidis and Histoplasma capsulatum-infected canine and feline lungs

195 tope in Blastomyces dermatitidis and also in Histoplasma capsulatum.

196 R5 during infection with the fungal pathogen Histoplasma capsulatum.

197 eople harbor latent infections of the fungus Histoplasma capsulatum.

198 control of infection by the dimorphic fungus Histoplasma capsulatum.

199 e human pathogens Coccidioides posadasii and Histoplasma capsulatum.

200 tective immunity in an Ag-specific manner to Histoplasma capsulatum.

201 ith recognition of the worldwide presence of Histoplasma capsulatum.

202 elevated in the lungs of mice infected with Histoplasma capsulatum.

203 sis influenced host resistance to the fungus Histoplasma capsulatum.

204 role of these agents in host defense against Histoplasma capsulatum.

205 influenced protective and memory immunity to Histoplasma capsulatum.

206 these genes in vivo, mice were infected with Histoplasma capsulatum.

207 ve domain (F3) of heat-shock protein 60 from Histoplasma capsulatum.

208 ion in the lungs of naive mice infected with Histoplasma capsulatum.

209 ith class 5 or 6 organisms than with class 2 Histoplasma capsulatum.

210 omoters of two yeast phase-specific genes in Histoplasma capsulatum.

211 nt of heat shock protein 60 from the fungus, Histoplasma capsulatum.

212 e during primary infection with the pathogen Histoplasma capsulatum.

213 of both primary and secondary infection with Histoplasma capsulatum.

214 ular genetic studies of the dimorphic fungus Histoplasma capsulatum.

215 sponse against Mycobacterium tuberculosis or Histoplasma capsulatum.

216 are essential for controlling infection with Histoplasma capsulatum.

217 inst many intracellular infections including Histoplasma capsulatum.

218 ell as to the natural CR3 ligands, iC3b, and Histoplasma capsulatum.

219 laboratory evidence of recent infection with Histoplasma capsulatum.

220 recombinant (r) hsp60 protects mice against Histoplasma capsulatum.

221 lution of infection with the fungal pathogen Histoplasma capsulatum.

222 fungal nitric oxide reductase (P450nor) from Histoplasma capsulatum.

223 TNF-alpha in CCR5(-/)(-) mice infected with Histoplasma capsulatum.

224 is) infected with the intracellular pathogen Histoplasma capsulatum.

225 charomyces cerevisiae, Candida albicans, and Histoplasma capsulatum.

226 Fourteen samples grew Histoplasma capsulatum; both systems detected H. capsula

227 To probe the contribution of Histoplasma catalases in oxidative stress defense, we cr

228 In addition, human immune sera recognize the Histoplasma Cfp4 protein, confirming Cfp4 production dur

229 This intracellular Histoplasma-containing compartment imposes nutritional c

230 These results indicate that the Histoplasma-containing phagosome is limiting for ribofla

231 Among the secreted proteome of Histoplasma, culture filtrate protein 4 (Cfp4) is a heav

232 ve shown previously that these two phases of Histoplasma differ in their calcium requirements for gro

233 ttle is known about the molecular biology of Histoplasma dimorphism.

234 concept that the assay can be used to detect Histoplasma DNA in urine.

235 ia), mycobacterial, and fungal (Aspergillus, Histoplasma, etc.) infections.

236 Both CatB and CatP protected Histoplasma from peroxide challenge in vitro and from an

237 Infected by the same inoculum of Histoplasma, gal3(-/-) mice had lower fungal burden and

238 ctured by IMMY (Norman, OK) for detection of Histoplasma galactomannan (GM) in urine using an enzyme

239 vation of the selectable URA5 marker (native Histoplasma gene or a heterologous Podospora anserina ge

240 ed vitamin synthesis pathways encoded in the Histoplasma genome and confirmed by growth in minimal me

241 omas occurred in hilar lymph nodes, although histoplasma granulomas involved hilar lymph nodes of thr

242 The virulence of Histoplasma has been linked to cell wall alpha-(1,3)-glu

243 ified an insertion in the locus encoding the Histoplasma Hsp82 homolog.

244 xamination of host cellular responses in the Histoplasma-induced granuloma representing the specific

245 s of this article is the characterization of Histoplasma-induced granulomas.

246 Incubation of Histoplasma-infected DC at 18 degrees C also concomitant

247 Unlike Mphi, Histoplasma-infected DC exhibited marked PL-fusion.

248 Further, culture of Histoplasma-infected DC in the presence of bafilomycin,

249 In contrast, culture of Histoplasma-infected DC in the presence of inhibitors of

250 The addition of suramin to Histoplasma-infected DC inhibited PL-fusion and DC fungi

251 Our study showed that Histoplasma infection induced gal3(-/-) dendritic cells

252 the fungal burden and are more sensitive to Histoplasma infection than wild-type, Dectin-1-/-, or in

253 onses in healthy volunteers with and without Histoplasma infection.

254 ted in 25 patients without evidence of prior Histoplasma infection.

255 ory therapy have a higher risk of developing Histoplasma infections.

256 low further analysis of key elements of host Histoplasma interactions at the site of chronic infectio

257 ne whether the mechanism(s) by which DC kill Histoplasma is via lysosomal hydrolases, via the product

258 g understanding of systemic immunity against Histoplasma, little is known about the local granulomato

259 tbreak of Exserohilum rostratum One study in Histoplasma meningitis found 53% (53/87) sensitivity and

260 are the GBA EIA to the MiraVista Diagnostics Histoplasma (MVH) EIA, which showed 91.3% (63 of 69), 98

261 To test the function of Cfp4 in Histoplasma pathogenesis, we generated Cfp4-deficient st

262 infection of host cells, supporting roles in Histoplasma pathogenesis.

263 antigen, or six urine specimens positive for Histoplasma polysaccharide antigens.

264 the calcium requirements of the two forms of Histoplasma, potentially implicating the phagolysosome a

265 ing a pyrimidine-rich motif found in several Histoplasma promoters.

266 ty patterns of multiple clinical isolates of Histoplasma representing different phylogenetic groups.

267 ined, in part because of the inefficiency of Histoplasma reverse genetics.

268 innate immune system are an integral part of Histoplasma's ability to survive during infection.

269 These results demonstrate that Histoplasma's dual catalases comprise a system that enab

270 Blastomyces, Coccidioides, Cryptococcus, and Histoplasma species.

271 es spp. (n = 10), Coccidioides spp. (n = 9), Histoplasma spp. (n = 7) and Blastomyces spp. (n = 3).

272 Linearized DNA and plasmids containing Histoplasma telomeric sequences showed the greatest tran

273 ual catalases comprise a system that enables Histoplasma to efficiently overcome the reactive oxygen

274 s of AMY1 function attenuated the ability of Histoplasma to kill macrophages and to colonize murine l

275 The mechanisms allowing Histoplasma to overcome toxic reactive oxygen molecules

276 IMMY GM ASR can be used to serially monitor Histoplasma UAg levels.

277 R is a reliable rapid assay for detection of Histoplasma UAg.

278 ble and quantifiable reporter gene by fusing Histoplasma URA5 with E. coli lacZ, resulting in express

279 Histoplasma urine antigen (UAg) detection is an importan

280 easts in macrophages and severely attenuated Histoplasma virulence in a murine model of respiratory h

281 aneous loss of both CatB and CatP attenuated Histoplasma virulence in vivo.

282 ing for riboflavin and pantothenate and that Histoplasma virulence requires de novo synthesis of thes

283 To identify new genes required for Histoplasma virulence, we employed these transgenic macr

284 -(1,3)-glucan is an important contributor to Histoplasma virulence.

285 o2 function (biotin synthesis) also impaired Histoplasma virulence.

286 To test the effectiveness of RNAi in Histoplasma, we depleted expression of a gfp transgene a

287 avin, pantothenate, and biotin auxotrophs of Histoplasma were generated to probe whether these vitami

288 ctor produced abundantly and specifically by Histoplasma yeast cells, suggesting its role in pathogen

289 6-well microtiter plate-based measurement of Histoplasma yeast growth in vitro.

290 ression markedly attenuates the virulence of Histoplasma yeast in vivo.

291 Histoplasma yeasts also secrete the putative glucanase E

292 d confirmed by growth in minimal medium that Histoplasma yeasts can synthesize all essential vitamins

293 Cfp4 does not confer a fitness advantage to Histoplasma yeasts during murine lung infection.

294 ular pathogens escape into the host cytosol, Histoplasma yeasts remain within the macrophage phagosom

295 These results show that Histoplasma yeasts secrete two beta1,3-glucanases and th

296 s forms, which highlights the need to employ Histoplasma yeasts, not hyphae, in antifungal susceptibi

297 monitor the effectiveness of antifungals on Histoplasma yeasts, the morphological form present in ma

298 of the total secreted glucanase activity of Histoplasma yeasts.

299 l beta-glucans to minimize host detection of Histoplasma yeasts.

300 Sod3) did not further reduce the survival of Histoplasma yeasts.