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1 r groove binding with the bisbenzimide drug (Hoechst 33258).
2 zation of A.T rich duplexes when compared to Hoechst 33258.
3 , with the B-DNA minor groove binding ligand Hoechst 33258.
4 elated to the well-known minor groove agent, Hoechst 33258.
5 wise combination with the DNA binding ligand Hoechst 33258.
6 es in binding of the DNA minor groove binder Hoechst 33258.
7 minor groove-binding drugs, distamycin A and Hoechst 33258.
8  to a similar extent as ethidium bromide and Hoechst 33258.
9 , with the B-DNA minor groove binding ligand Hoechst 33258.
10 psins, and the classic monomeric DNA binders Hoechst 33258, 4'-diamino-2-phenylindole, pentamidine, b
11          The bibenzimidazoles, which include Hoechst 33258 and 33342, are a family of DNA minor groov
12  analyses to define the DNA binding site for Hoechst 33258 and a related derivative that results in o
13 ycin D) and minor groove binders (netropsin, Hoechst 33258 and distamycin) has shown the suitability
14 ults in loss of orientational specificity of Hoechst 33258 and formation of multiple bound species in
15 n cooperativity of binding for netropsin and Hoechst 33258 and have provided ligand:DNA binding ratio
16  the minor groove widths in the complexes of Hoechst 33258 and the meta-hydroxyl derivative as a resu
17 e, ethidium homodimer, bis-benzimide (DAPI), Hoechst 33258 and thiazole orange] to function as suitab
18                     Apoptosis was assayed by Hoechst 33258 and TUNEL staining and DNA laddering.
19 escence employing the high-affinity DNA dyes Hoechst 33258 and YOYO-1 was able to resolve two sequent
20 odified SPGEs, redox active molecules namely Hoechst-33258 and a portable potentiostat.
21 nts including distamycin A, netropsin, DAPI, Hoechst 33258, and berenil is described.
22  of the novel conjugate containing neomycin, Hoechst 33258, and pyrene.
23  DAPI was more effective than distamycin and Hoechst 33258 at inhibiting the assembly of nucleosomes
24 romide and facilitate cooperative binding of Hoechst 33258 at the minor groove.
25                                  A series of Hoechst 33258 based mono- and bisbenzimidazoles have bee
26         We report herein novel neomycin- and Hoechst 33258-based conjugates developed in our laborato
27                                 In contrast, Hoechst 33258 binds approximately 20-fold more tightly t
28 e shown that the minor groove-binding ligand Hoechst 33258 binds to the two T4/A4 tracts within the d
29                                              Hoechst 33258 binds with a dissociation constant of 60 n
30 NA, surpassing the sensitivity achieved with Hoechst 33258 by 400-fold.
31                        Both distamycin A and Hoechst 33258 can inhibit, to a similar extent, the bind
32          Described herein are novel neomycin-Hoechst 33258 conjugates developed for exploring B-DNA g
33                         The multicyclic dyes Hoechst 33258, DAPI, and berenil bind to TAR RNA in a si
34 r AT-selective minor groove binding ligands (Hoechst 33258, distamycin, netropsin and berenil) with D
35 ound previously in other X-ray structures of Hoechst 33258-DNA complexes.
36 and DNA.DNG-H duplexes formed by DNG and DNG-Hoechst 33258 (DNG-H) conjugates with 30-mer double-stra
37 n fluorescent protein as a tumor marker, and Hoechst 33258 dye as an intravital endothelial stain.
38 es the phosphodiester linkages, tethering to Hoechst 33258 fluorophore by varying lengths has been sy
39 ynamics experiments of the fluorescent probe Hoechst 33258 (H33258) bound to DNA, we have generated 7
40 matically examined the bis-benzimidazole dye Hoechst 33258 (H33258) in terms of self-aggregation and
41 bis-benzimidazole minor groove binding agent Hoechst 33258 (H33258), has been studied by NMR and rest
42 ulation of a DNA-binding fluorescent cation, Hoechst 33258 (H33258), in cervical cancer cells.
43  its 2:1 complex with the bis -benzimidazole Hoechst 33258 has been investigated by NMR and NOE-restr
44                               Distamycin and Hoechst 33258 have long served as the model compounds fo
45 nase co-localized with the nuclear DNA stain Hoechst 33258 in each cell type.
46 ay showed greater dsDNA:RNA selectivity than Hoechst 33258 in low ionic strength buffer and better ds
47 GCG)2and an analogue of the DNA binding drug Hoechst 33258, in which the piperazine ring has been rep
48   In contrast, the known minor groove binder Hoechst 33258 inhibits the cross-link formation with a C
49  amino acid linkers and a bis-benzimidazole (Hoechst 33258) ligand at the 5'-terminus using PyBOP/HOB
50 d to improve the efficacy of pentamidine and Hoechst 33258 ligands that have been shown previously to
51 analysis of toxin-treated cells stained with Hoechst 33258 (or 33342) and 7-aminoactinomycin D allowe
52                                       Unlike Hoechst 33258, PicoGreen reagent fluorescence intensity
53 ing the DNA amplification was achieved using Hoechst 33258 redox molecule and linear sweep voltametry
54                                Staining with Hoechst 33258 revealed that about 75% of cells exhibited
55  DNA in the presence of ethidium bromide and Hoechst 33258 revealed that minor groove binding is more
56                                              Hoechst 33258 shows a similar pattern of preference, wit
57 densation and DNA breaks were assessed using Hoechst 33258 staining and DNA nickend labeling, and DNA
58 ration, suppressed cell death as measured by Hoechst 33258 staining, induced peroxisomal beta-oxidati
59 orting on the basis of polyamide binding and Hoechst 33258 staining.
60 ed by annexin V staining, DNA laddering, and Hoechst 33258 staining.
61 orochrome bis (benzimide) trihydro-chloride (Hoechst 33258) staining.
62 ex with a tetrahydropyrimidinium analogue of Hoechst 33258 suggest that DNA minor groove recognition
63 ing to examine the ability of distamycin and Hoechst 33258 to discriminate between different arrangem
64                                        Since Hoechst 33258 was identified as a DM1 binder through ana
65      An analogue of the DNA binding compound Hoechst 33258, which has the para hydroxyl group altered
66 display a derivative of the bisbenzimidazole Hoechst 33258, which was identified by searching known R
67 benzimidazole DNA minor groove binding agent Hoechst 33258 with the decamer duplex d(GCAAATTTGC)2.
68 ed to examine the binding characteristics of Hoechst 33258 with the extended AT-tract DNA duplex d(CG
69      The role of water in the interaction of Hoechst 33258 with the minor groove binding site of the