ライフサイエンスコーパス: Hox gene

1 uman Hox loci, but does not itself contain a Hox gene.

2 nt cis-regulatory elements into contact with Hox genes.

3 ith changes in the function or regulation of Hox genes.

4 ly methylated and expressed include multiple HOX genes.

5 he specific induction of Hoxa9 but not other Hox genes.

6 not by changes in the function of primaxial Hox genes.

7 vent age-related epigenetic changes in these HOX genes.

8 tions at the promoter region of 37 zebrafish hox genes.

9 mation and differentiation, including distal Hox genes.

10 keleton requires the coordinated activity of Hox genes.

11 enes, known to act as upstream regulators of Hox genes.

12 development as a consequence of mutations in HOX genes.

13 d early in development through the action of Hox genes.

14 3K27me3 and defective Polycomb repression of HOX genes.

15 cent glands express vvl and are regulated by Hox genes.

16 ypes for two Hox mutants, with 8 or 9 mutant Hox genes.

17 ates gene transcription, including homeobox (HOX) genes.

18 identified evolutionary modifications in the Hox gene Abd-B that dramatically altered its expression

19 locus between the abdominal fate-determining Hox genes, abd-A and Abd-B, controls the red-black color

20 of Polycomb group-mediated repression of the Hox gene Abdominal-B (Abd-B) caused the transformation o

21 ore, gene expression analysis shows that the Hox gene Abdominal-B (Abd-B) represents one of the targe

22 le-specific isoform of Dsx collaborates with Hox gene Abdominal-B (Abd-B) to bring about this apoptos

23 g RNAs (lncRNAs) are critical for regulating HOX genes, aberration of which is a dominant mechanism f

24 Our results support a mechanism in which Hox genes act upstream of Tbx5 to control the axial posi

25 ified lineages and requires lineage-specific Hox gene action to ensure the correct formation of adult

26 nces that changes in the timing of collinear Hox gene activation might underlie natural variation in

27 ined the role of chromatin regulators during Hox gene activation.

28 esults in abnormal development and defective hox gene activation.

29 SS family members has little effect on early Hox gene activation.

30 ecently validated by molecular phylogeny and Hox genes analyses.

31 vo, we interrogated their role in regulating Hox genes and body segment identity using Moz;Bmi1 doubl

32 s, using CRISPR/Cas9 and fate mapping, of 5' hox genes and enhancers in zebrafish that are indispensa

33 e near the N terminus, which is unique among HOX genes and highly conserved in higher mammals.

34 clusters of tandemly duplicated genes (e.g., Hox genes and histones).

35 Here, we describe the function of Hox genes and homothorax (hth), which encodes a Hox co-f

36 s, suggesting extensive interactions between Hox genes and hormone-controlled regulatory networks to

37 se outcome predictors, and overexpression of HOX genes and HOX-gene-embedded microRNAs in low MN1 exp

38 n is significant in most of the 39 mammalian Hox genes and in other homeobox-containing transcription

39 dentities of these segments are specified by Hox genes and other axis patterning genes during develop

40 the "OFF" and "ON" transcriptional states of HOX genes and other targets by modulation of chromatin s

41 effects of interference with the function of Hox genes and Tc-hth/Tc-exd during metamorphosis did not

42 Rgamma increases the expression of posterior Hox genes and that of marker genes for presomitic mesode

43 esponsible for the synchronous regulation of Hox genes and the molecular function of their colinearit

44 miR-196 injection altered expression of hox genes and the signaling of retinoic acid through the

45 ription factors and segmental expressions of Hox genes and their accessory proteins.

46 rprisingly, elevated expression of different Hox genes and various other transcription factors, such

47 We propose that 5'Hoxd genes and Gli3 are part of an interdigital signalli

48 In aged cells the same HOX genes (and additionally HOXC-AS3) displayed the most

49 ry origin remains obscure, due to absence of Hox genes (and their evolutionary sisters, the ParaHox g

50 row MSCs express other regionally restricted Hox genes, and femur fractures heal normally in Hox11 mu

51 Low EZH2 levels resulted in derepression of HOX genes, and knockdown of HOXB7 and HOXA9 in the resis

52 nscription factors such as SOX6, POU3F2, and HOX genes; and identify striking examples of adaptive re

53 legs develop in the expression domain of the Hox gene Antennapedia (Antp), whereas the Hox genes Ultr

54 A single Hox gene, Antennapedia (Antp), is primarily responsible

55 In the developing embryo, Hox genes are activated sequentially in time and space a

56 ny animal species with a bilateral symmetry, Hox genes are clustered either at one or at several geno

57 Hox genes are conserved transcription factor-encoding ge

58 Vertebrate Hox genes are critical for the establishment of structur

59 we demonstrate that a considerable number of HOX genes are differentially epigenetically regulated in

60 Hox genes are essential regulators of embryonic developm

61 Hox genes are evolutionarily conserved transcription fac

62 Wnt and several Hox genes are expressed at the posterior pole, whereas W

63 the function of Hox proteins is less clear: Hox genes are expressed during tissue repair, but in thi

64 Here we show that Hox genes are expressed in periosteal stem/progenitor ce

65 Hox genes are indispensable for the proper patterning of

66 Hox genes are key regulators of development.

67 Hox genes are key regulators of stem cells and tissue pa

68 Hox genes are known to determine vertebral identity alon

69 rphogenesis, and suggest that this and other Hox genes are likely to have important roles during regi

70 transcriptomic analyses show that brachiopod Hox genes are neither strictly temporally nor spatially

71 Thus, Hox genes are not simply regulators of skeletal morpholo

72 Hox genes are renowned for patterning animal development

73 results in ectopic lineages suggesting that Hox genes are required for lineage-specific termination

74 res of subfunctionalisation of paralogues of Hox genes are revealed in the appendages of two species

75 However, Cdx genes and multiple Hox genes are stage-specific targets of Sp1 and are down

76 Mammalian Hox genes are targets of Polycomb proteins and form loca

77 Homeotic (HOX) genes are dysregulated in multiple malignancies, in

78 The homeotic (Hox) genes are highly conserved in metazoans, where they

79 xamples of homeobox containing genes are the Hox genes, arranged on chromosomes in the same order as

80 gf and Notch signalling components, and many Hox genes as progenitors transit from production of the

81 observe several novel genomic regions (e.g., HOX genes) as being epigenetically regulated.

82 Here we characterize the expression of HoxD genes, as well as the cluster-associated genes Evx2

83 lopmental contexts as upstream regulators of Hox genes-as factors that interact with non-HOX proteins

84 How HOX gene-associated lncRNAs regulate hematopoietic stem

85 arthropods by altering the role of distinct Hox genes at different levels of their action.

86 ism of action for Psip1 in the regulation of Hox genes but also suggest an unexpected interplay betwe

87 full transcriptional activation of multiple Hox genes but functions independently of the E1 and E2 c

88 ontrolling this spatiotemporal expression of Hox genes, but disentangling their relative contribution

89 Changing expression of Hox genes can have widespread effects, given their impor

90 families, including the apparent absence of HOX genes, canonical microRNA machinery, and reduced imm

91 etinoic acid drove trunk-related markers and HOX genes characteristic of a posterior identity.

92 We used ORCA to study a Hox gene cluster in cryosectioned Drosophila embryos and

93 uster, evolutionarily closely related to the Hox gene cluster.

94 elate it to genomic imprinting and homeobox (Hox) gene cluster repression.

95 organization of chromatin at and around the HoxD gene cluster and report that although the two TADs

96 The HoxD gene cluster is critical for proper limb formation

97 ons in 3D interactions within and around the HoxD gene cluster.

98 ral collinearity might contribute to keeping Hox genes clustered.

99 gest spatial network is composed of the four Hox gene clusters and early developmental transcription

100 nding sites within vertebrate and Drosophila Hox gene clusters have been maintained for several hundr

101 s often considered the main force preserving Hox gene clusters in animal genomes.

102 Further we tested, whether paralogs of Hox gene clusters originated from this paddlefish specif

103 correlation between the presence of CTCF and Hox gene clusters throughout the animal kingdom suggests

104 e according to their genomic position within Hox gene clusters.

105 The HoxA and HoxD gene clusters of jawed vertebrates are organized in

106 s not previously characterized and show that HOX genes confine them to the thoracic segments.

107 However, whether Hox genes continue to function after development has not

108 volved in cell differentiation and Homeobox (Hox) gene control.

109 Hox genes controlling motor neuron subtype identity are

110 tic sub-types converge on high expression of HOX genes, critical for their self-renewal.

111 sion in the peripodial epithelium, while the Hox gene Deformed represses labial in this location, thu

112 f mutants containing individual and combined hox gene deletions in a common parental strain reveals a

113 We previously described HOX genes deregulation to be involved in hepatocarcinoge

114 In vertebrates and other metazoans, Hox genes determine cell fate along the anteroposterior

115 udy provides the first in vivo evidence that Hox genes determine oligodendrocyte regional identity in

116 The Hox genes Dfd, Scr, and Antp are expressed in a lineage-

117 briefly introduce the field of evo-devo and Hox genes, discuss functional tools available to study e

118 We find that lamprey hox genes display dynamic segmentally restricted domains

119 osteology in fossil and modern amniotes with Hox gene distributions within Amniota indicates that a f

120 iation, in part, through MLL degradation and HOX gene down-regulation.

121 In humans, acquired deregulation of HOX genes during adulthood has been linked to carcinogen

122 provided to understand the precise roles of Hox genes during crustacean development.

123 cates a tight control of axial patterning by Hox genes during development.

124 rangement of nucleosomes at the promoters of hox genes during early development.

125 d resolution and activation of many bivalent Hox genes during mouse ESC differentiation were recapitu

126 d BMI1, respectively, promoted and repressed Hox genes during the shift from the transcriptionally re

127 identity within appendages independently of Hox genes during this stage.

128 tically heritable silencing of the homeotic (HOX) genes during development.

129 shown that the transcriptional activation of Hoxd genes during vertebrate digit development involves

130 tral position for initiating and maintaining HOX gene dysregulation as a driving leukemogenic force.

131 dictors, and overexpression of HOX genes and HOX-gene-embedded microRNAs in low MN1 expressers.

132 Hox genes encode a conserved family of homeodomain trans

133 Although Hox genes encode for conserved transcription factors (TF

134 How Hox genes encode this specificity is a paradox, because

135 Hox genes encode transcription factors (TFs) that establ

136 Vertebrate Hox genes encode transcription factors operating during

137 HOX genes encode transcription factors regulating embryo

138 nockdown to decipher the function of the six Hox genes expressed in the developing mouth and trunk of

139 in patterning and development by controlling Hox gene expression and cell stress signaling.

140 easome prevented EZH2 degradation, decreased HOX gene expression and restored drug sensitivity.

141 back to reduce variability while keeping the Hox gene expression at elevated levels.

142 t the homeotic transformations and shifts in Hox gene expression boundaries observed in single Moz an

143 monstrate that post-developmental changes in Hox gene expression can modulate behavior in the adult.

144 that epigenetically regulated alterations of HOX gene expression can trigger changes in the transcrip

145 Although shifts in Hox gene expression domains have been postulated to play

146 s been explained as either homogenization of Hox gene expression domains, or retention of standard ve

147 HoxA and HoxB complexes evolved to modulate Hox gene expression during mammalian cardiac and endoder

148 In addition, we define how changes in Hox gene expression have generated morphological differe

149 2 functions as master regulator of perturbed HOX gene expression in human acute myeloid leukemia, loc

150 BMI1 play opposing roles during the onset of Hox gene expression in the ES cell model and during body

151 role in determining the anterior boundary of Hox gene expression in the neural tube during embryogene

152 Lastly, we provide evidence that Hox gene expression is one potential mechanism that main

153 port that LMP1 is important to establish the Hox gene expression signature in NPC cell lines and tumo

154 Our results show that coupling of Hox gene expression to segmentation of the hindbrain is

155 Our comprehensive evaluation of HOX gene expression using tiling microarrays, with valid

156 expression in the thorax, in the absence of Hox gene expression, features three lateral cell cluster

157 but has no effect on global H3K27me3 level, Hox gene expression, or ES cell self-renewal.

158 reciated role during the initiation phase of Hox gene expression, which is critical for the correct s

159 ation with segmentally restricted domains of Hox gene expression.

160 s mature, thus coinciding with a decrease in HOX gene expression.

161 rentiation through dose-dependent effects on Hox gene expression.

162 inal reader proteins regulate joint-specific HOX gene expression.

163 rior axis could also be assigned using adult Hox gene expression.

164 the primary mechanism involved in regulating HOX genes expression in the placenta.

165 igit enhancers are conserved in pythons, and HOXD gene expression in the hindlimb buds progresses to

166 The contribution of HOX genes' expression to the development of NPM1-mutated

167 Oct4 also shifted posterior Hox gene-expression boundaries in the extended trunks, t

168 The importance of the Hox gene families in vertebral development was highlight

169 Hoxa5 is a member of the Hox gene family, which plays critical roles in successiv

170 Members of the highly conserved homeobox (HOX) gene family encode transcription factors that confe

171 We report that repressed Hox genes form mutual intra- and interchromosomal intera

172 uced ambiguous although studies of posterior Hox genes from homology group 13 (Hoxa-13 and Hoxd-13) r

173 similarities also require similar changes in Hox gene function is disputed.

174 ng the importance of posterior prevalence in Hox gene function.

175 First, Hox genes function as activators, modifiers, and suppres

176 The products of Hox genes function in assigning positional identity alon

177 There is also emerging evidence that Hox genes function in multiple neuronal classes to shape

178 comparisons of RNAi phenotypes indicate that Hox genes function jointly with Tc-hth and Tc-exd to spe

179 The Hox gene fushi tarazu (ftz) arose as a homeotic gene but

180 Hoxc8 in mice revealed that this midthoracic Hox gene has transient but strong regional expression in

181 nhancer elements that drive expression of 5' Hoxd genes, has yet to be fully elucidated.

182 Hox genes have been shown to be essential in vertebrate

183 ts, and provide examples in which changes in Hox genes have contributed to changes in body plan or mo

184 Hox genes have long been suspected to control limb posit

185 Posterior Hox genes (Hox9-13) are critical for patterning the limb

186 date, only the five most posterior groups of Hox genes, Hox9-Hox13, have demonstrated loss-of-functio

187 n humans revealed that mutations in a single Hox gene, HOXA1 (Athabascan Brainstem Dysgenesis Syndrom

188 We show that two Hox genes, Hoxa5 and Hoxc5, control diverse aspects of P

189 bations on the transcriptional regulation of Hoxd genes illustrate the requirement of this regulatory

190 erentiation and it is the earliest expressed Hox gene in the mouse embryo.

191 tly patterned by the collinear activation of Hox genes in a two-step process.

192 Given the importance of both LMO2 and HOX genes in acute leukaemias, we further demonstrated t

193 ribes a novel post-developmental role of the Hox genes in adult neural function.

194 Remarkably, expression of the Hox genes in both brachiopod species demonstrates coopti

195 The discovery of Hox genes in Drosophila, and their subsequent identifica

196 itional identity, and the modulatory role of Hox genes in fate decisions may offer potential druggabl

197 ts, as well as recent studies of the role of Hox genes in generating regional specification within th

198 ciency also decreased expression of multiple Hox genes in hematopoietic progenitors.

199 ology', which refers to the critical role of HOX genes in metazoan evolution, we propose to introduce

200 erases is known to activate transcription of Hox genes in other contexts, we found that individual in

201 LMP1 induces repression of several Hox genes in part via stalling of RNA polymerase II (RNA

202 reports have demonstrated crucial roles for Hox genes in patterning the axial and limb skeleton.

203 b) demonstrate that coordinate activities of Hox genes in sensory neurons and interneurons govern con

204 brachiopod species demonstrates cooption of Hox genes in the chaetae and shell fields, two major lop

205 esults identify novel molecular functions of Hox genes in the development of the male and female repr

206 The role of Hox genes in the formation of cutaneous accessory organs

207 g activity in vitro, decreased expression of Hox genes in the hematopoietic stem cells, and decreased

208 finds that differential expression timing of Hox genes in the lateral plate mesoderm determines limb

209 g in avians show a direct and early role for Hox genes in this process.

210 e the complement, cluster, and expression of Hox genes in two brachiopod species, Terebratalia transv

211 on of defined roles for endogenous homeobox (Hox) genes in adult hematopoietic stem and progenitor ce

212 this study, we have analyzed the function of Hoxd genes in delayed growth trajectories by looking at

213 ic TAD subsequently regulates more posterior Hoxd genes in digit cells.

214 eric TAD controls the early transcription of Hoxd genes in forearm cells, whereas the centromeric TAD

215 These new data support an ancestral role for HoxD genes in patterning the fin-folds of jawed vertebra

216 q23-AML facilitate transcription of a set of HOX genes, including HOXA9 and HOXA10.

217 nstrate conserved synteny involving nrf2 and hox genes, indicating that nrf2a and nrf2b are co-orthol

218 re by which some appendages are patterned by Hox gene inputs.

219 Separating hox genes into expressed and non-expressed groups shows

220 The genomic arrangement of Hox genes into four paralogous clusters is a primitive f

221 bless, we recovered coding sequences for all Hox genes involved in amniote limb development, with the

222 binations, suggesting that the role of these Hox genes is to limit PGC development with respect to th

223 s (i.e., piwil1) or early development (i.e., hox genes) is methylated, but the loci are demethylated

224 a segment is determined by the complement of Hox genes it expresses.

225 mi1 elicits a derepression of more posterior Hox genes, leading to a switch in MN fates.

226 itive, tripotent state, while suppression of Hox genes leads to fate changes with loss of tripotency.

227 upts topological boundaries such that caudal Hox genes leave the repressed domain and become subject

228 In mouse embryos, Hox genes located at the 3' end of HoxA and HoxB complex

229 Hox gene loss-of-function causes lineage-specific defect

230 We hypothesized that HOX genes may be implicated in the development of BE.

231 sults in homeotic transformations typical of Hox gene misregulation.

232 ization of oligodendrocytes is controlled by Hox genes, namely Hoxa2 and Hoxb2.

233 ruption of promoter-promoter contacts in the Hox gene network.

234 w highlights the functions and mechanisms of Hox gene networks and their multifaceted roles during ne

235 Together, our data describe an adult role of Hox genes other than positional identity, and the modula

236 ves myeloid leukemogenesis in the context of Hox gene overexpression but is currently considered undr

237 m1(cA);Flt3(ITD) share a number of features: Hox gene overexpression, enhanced self-renewal, expansio

238 the chicken embryo, activation of posterior Hox genes (paralogs 9-13) in the tail-bud correlates wit

239 During embryonic development, Hox genes participate in the building of a functional di

240 Hox genes pattern the anterior-posterior axis of animals

241 The Hox genes play a central role in patterning the embryoni

242 In jawed vertebrates (gnathostomes), Hox genes play an important role in patterning head and

243 Our results allow us to define the role Hox genes play in specifying each appendage type in Parh

244 Because hox genes play pivotal developmental roles in bilaterian

245 homeobox gene families such as the clustered Hox genes play pivotal roles both in normal and malignan

246 e on chromatin and are found associated with Hox gene promoter regions.

247 esponse elements (PREs) of certain Homeobox (Hox) genes, providing a rationale for why Jarid2 was nev

248 ment when the GCR participates in initiating Hoxd gene quantitative collinearity and Hoxd13 expressio

249 We show that Hox gene read-through transcripts can be spliced to prod

250 Hox genes regulate regionalization of the axial skeleton

251 , where ct is positively regulated by trh As Hox genes regulate trh, we can now mechanistically expla

252 of the previously known interaction between Hox gene regulation and CTCF.

253 in cells and have implications for miRNA and Hox gene regulation during development.

254 ting the expression patterns, functions, and Hox gene regulation of trachealess (trh), ventral veinle

255 Despite numerous layers of Hox gene regulation, these IRES elements are essential f

256 We propose that Hoxd gene regulation in embryonic MBs evolved by hijacki

257 ite both the absence of limbs and an altered Hoxd gene regulation in external genitalia, the limb-ass

258 The latter DNA region is also involved in Hoxd gene regulation in other contexts and strongly inte

259 , once established at a repressed Drosophila HOX gene, remain heritably associated with that gene and

260 s, differentiating its role from neighboring Hox genes, rendering it nonredundant.

261 r LMC neurons by the expression of a variant Hox gene repertoire and by the failure to express a key

262 e emerging limb buds, different subgroups of Hoxd genes respond first to a proximal regulatory signal

263 ession of multiple Hoxb genes and attenuated Hox gene response to exogenous RA treatment in utero.

264 ng transcript levels of some or all of these Hox genes results in supernumerary and/or ectopic PGCs,

265 In numerous insect species, the Hox genes Sex-combs reduced (Scr), Antennapedia (Antp),

266 asts from different joint locations and that HOX gene signatures reflect the joint-specific origins o

267 On the other hand, Hox genes specify appendage identities along the anterop

268 Although Hox genes specify the differentiation of neuronal subtyp

269 late timing reduces this pleiotropy, making Hox genes suitable targets.

270 We found that the key Hox gene that orients Q neuroblast migration exhibits in

271 [5], which is congruent with a shared unique Hox gene that suggests a close relationship between Gnat

272 ral tube leads to differential expression of Hox genes that contribute to the specification of motor

273 domen of insects-and that they have lost the Hox genes that originally specified this region.

274 on factors, such as LHX9, TBX1, and multiple HOX genes, that are considered fundamental regulators of

275 ave underscored that in addition to encoding Hox genes, the homeotic clusters contain key noncoding R

276 Unlike clustered HOX genes, the role of nonclustered homeobox gene family

277 Hoxa3 was the first Hox gene to be mutated by gene targeting in mice and is

278 esults reveal multiple regulatory layers for Hox genes to fine-tune transcriptional programs essentia

279 ol modules act over a long range on multiple Hox genes to generate nested patterns of HoxA and HoxB e

280 d and jaw formation, but mechanisms coupling Hox genes to neural crest (NC) are unknown.

281 cture is instrumental in allowing vertebrate Hox genes to pattern disparate parts of the body, includ

282 e cells to assess the response of the target Hoxd genes to these two factors.

283 The shared and specific expression of Hox genes, together with Arx, Zic, and Notch pathway com

284 oic acid-signaling pathway, we disrupt early hox gene transcription, but observe no effect on nucleos

285 is particular regulatory topology to control Hoxd gene transcription in time and space, we either del

286 a range of regulatory elements required for Hoxd gene transcription, and it is often disrupted and/o

287 drive parasegment-specific expression of the Hox genes Ubx, abd-A, and Abd-B The Fab-7 boundary is lo

288 g behavior in part through repression of the Hox gene Ultrabithorax (Ubx) in a specific set of adult

289 ts across insect species have shown that the hox gene Ultrabithorax (Ubx) is necessary to promote hin

290 RNA targets involved in this behavior is the Hox gene Ultrabithorax, whose derepression in two metame

291 he Hox gene Antennapedia (Antp), whereas the Hox genes Ultrabithorax (Ubx) and abdominal-A mediate le

292 Hox genes underlie the specification of body segment ide

293 Posterior Hox genes were proposed to be major players in trunk len

294 hat a subset of progressively more posterior Hox genes, which are collinearly activated in vertebral

295 The clustered Hox genes, which are highly conserved across metazoans,

296 a concomitant delay in activation of caudal Hox genes, which are proposed to signal the end of axis

297 Among them are the Hox genes, which define different identities along the a

298 e recruitment of UTX-containing complexes to HOX genes, which results in demethylation of histone H3

299 ession of key developmental genes, including Hox genes whose temporal and spatial expression is tight

300 Special attention was given to hox genes, with hoxa13a being of particular interest and