ライフサイエンスコーパス: Hyp

1 hesis to incorporate Fmoc-hydroxyproline (4R-Hyp).

2 r proteins to form (2S,4R)-4-hydroxyproline (Hyp).

3 ollagen breakdown amino acid hydroxyproline (Hyp).

4 a Pro residue to produce 2-hydroxyproline (2-Hyp).

5 on and quantification of L-4-Hydroxyproline (Hyp).

6 tides additionally contain 4-hydroxyproline (Hyp).

7 in the order Pro < Hyp < [alpha-(1,4)GlcNAc]Hyp.

8 the safety and immunogenicity of daclizumab HYP.

9 nicity of extended treatment with daclizumab HYP.

10 A did not affect RPP but normalized dP/dt in HYP.

11 al reversibility of increased anaplerosis in HYP.

12 ates, and forms succinate and CO2 as well as Hyp.

13 n, where Xaa usually is Pro and Yaa often is Hyp.

14 ontext of cis-trans isomerization of Pro and Hyp.

15 nce of a hydration network in the absence of Hyp.

16 as source for the hydroxyl group oxygen of 2-Hyp.

17 to use free l-proline as a precursor to form Hyp.

18 HyP-1 exhibits selectivity for hypoxic activation in vit

19 HyP-1 features an N-oxide trigger that is reduced in the

20 HyP-1 is also compatible with NIR fluorescence imaging,

21 Reduction of HyP-1 produces a spectrally distinct product, facilitati

22 ese limitations, we present Hypoxia Probe 1 (HyP-1), a hypoxia-responsive agent for photoacoustic ima

23 We show that Hyp(10) disrupts only a small region of the alpha-helix

24 Replacement of Hyp(10) with N(8)Q results in a Mg(2+)-complexed end-to-

25 However, replacement of Hyp(10) with Pro(10) allowed the resulting peptide to re

26 (Gly-Pro-4(R)Hyp)(10) folds approximately 2000 times faster than (Gly

27 Hyp-[(14)C]Gal monosaccharide and Hyp-[(14)C]Gal disaccharide were identified in the base

28 Hyp-[(14)C]Gal monosaccharide and Hyp-[(14)C]Gal disacch

29 an SHAM but was lowered with PDH activation: HYP=1419+/-220 nmol/g dry weight; HYP+DCA=343+/-56 nmol/

30 Both Hyp(2) and betaPro(2) substitution decreased receptor af

31 eptide H-(Gly-Pro-4(R)Hyp)3-(Gly-3(S)Hyp-4(R)Hyp)2-(Gly-Pro-4(R)Hyp)4-OH to 1.80 A resolution.

32 , both isolated from interferon alpha2b-(Ser-Hyp)(20), and a 14-residue Hyp-AG isolated from (Ala-Hyp

33 structure of the polypeptide H-(Gly-Pro-4(R)Hyp)3-(Gly-3(S)Hyp-4(R)Hyp)2-(Gly-Pro-4(R)Hyp)4-OH to 1.

34 peptide containing the isostere, Ac-(Gly-Pro-Hyp)3-Gly-psi[(E)CH C]-Pro-Hyp-(Gly-Pro-Hyp)4-Gly-Gly-Ty

35 alkane-soluble Zintl cluster, [eta(4)-Ge(9)(Hyp)(3)]Rh(COD), that can catalytically hydrogenate cycl

36 -Pro-Hyp)3-Gly-psi[(E)CH C]-Pro-Hyp-(Gly-Pro-Hyp)4-Gly-Gly-Tyr-NH2, had a Tm value of 28.3 degrees C.

37 The fTHP [sequence: Gly-mep-Flp-(Gly-Pro-Hyp)4-Gly-Lys(Mca)-Thr-Gly-Pro-Leu-Gly-Pro-Pro-Gly-Lys(D

38 o-Leu-Gly-Pro-Pro-Gly-Lys(Dnp)- Ser-(Gly-Pro-Hyp)4-NH2] had a melting temperature (Tm) of 36.2 degree

39 (R)Hyp)3-(Gly-3(S)Hyp-4(R)Hyp)2-(Gly-Pro-4(R)Hyp)4-OH to 1.80 A resolution.

40 he polypeptide H-(Gly-Pro-4(R)Hyp)3-(Gly-3(S)Hyp-4(R)Hyp)2-(Gly-Pro-4(R)Hyp)4-OH to 1.80 A resolution

41 , and a 14-residue Hyp-AG isolated from (Ala-Hyp)(51)-green fluorescent protein.

42 -fold in the main body hypodermal syncytium, hyp 7.

43 zed and incorporated into a host Ac-(Gly-Pro-Hyp)8-Gly-Gly-Tyr-NH2 peptide to investigate the effect

44 f the 3634 genes were annotated as conserved HyP (9.5%) along with 887 HyP genes (24.4%).

45 TAG content in HYP (9.7+/-0.7 micromol/g dry weight) was lower than SHA

46 brate collagen has (2S,4R)-4-hydroxyproline (Hyp), a C(gamma)-exo-puckered Pro derivative, in the Xaa

47 ing multiple sclerosis to compare daclizumab HYP, administered subcutaneously at a dose of 150 mg eve

48 ssed in tobacco cells; that is, a 22-residue Hyp-AG and a 20-residue Hyp-AG, both isolated from inter

49 eron alpha2b-(Ser-Hyp)(20), and a 14-residue Hyp-AG isolated from (Ala-Hyp)(51)-green fluorescent pro

50 cently we described the structure of a small Hyp-AG putatively based on repetitive trigalactosyl subu

51 hat is, a 22-residue Hyp-AG and a 20-residue Hyp-AG, both isolated from interferon alpha2b-(Ser-Hyp)(

52 The Hyp-AGs were isolated from two different arabinogalactan

53 ed by type II O-Hyp-linked arabinogalactans (Hyp-AGs) are structural components of the plant extracel

54 o establish the molecular structure of these Hyp-AGs, which share common features: (i) a galactan mai

55 onfirmed at 12 weeks was 16% with daclizumab HYP and 20% with interferon beta-1a (P=0.16).

56 accomplish this, expression profiles of 1234 HyP and conserved genes were used from transcriptomic da

57 NA expression (129- and 124-fold increase in Hyp and Dmp1(-/-) vs. 1.3-fold in Hyp+SU5402 and 2.5-fol

58 Moreover, treatment of Hyp and FGF23R1760-transgenic mice with the CYP24 inhibi

59 ix conformation and stabilisation (Gly, Pro, Hyp and Hyl), whilst the Lys content was greater for the

60 We generated Hyp and klotho double-mutant mice (Hyp/klotho(-/-)).

61 tect bone sialoprotein (BSP) distribution in Hyp and WT mouse molar tissues, and transmission electro

62 Hypothetical (HyP) and conserved HyP genes account for >30% of sequenc

63 lpha-ImI were synthesized with either Pro or Hyp, and their in vitro oxidative folding and biological

64 e, inhibiting FGFR signaling using SU5402 in Hyp- and Dmp1(-/-)-derived bone marrow stromal cells pre

65 ly characterized by the presence of [Alanine-Hyp] ([AO]) repetitive units.

66 09 m [5280 feet]), and severe high altitude (HYP) ( approximately 5182 m [ approximately 17,000 feet]

67 In addition to the lack of Hyp-Ara in hpat1/3 pollen tubes (PTs), we also found bro

68 To monitor the trafficking of Hyp-Ara modified proteins, we generated an HPAT-targeted

69 e a post-translational protein modification (Hyp-Ara) found abundantly on cell wall structural protei

70 yst function bypassed the PT requirement for Hyp-Ara.

71 7 as a candidate for the transfer of Araf to Hyp-arabinofuranotriose (Hyp-beta1,4Araf-beta1,2Araf-bet

72 f) side chains in an alpha-linkage, to yield Hyp-Araf4 which is exclusively found in extensins.

73 n the Viridiplantae along with its' product, Hyp-Araf4, point to ExAD being an evolutionary hallmark

74 eaving the imidodipeptides containing pro or hyp at the C-terminal end.

75 tification of the catabolic pathway in which Hyp-B 2-epimerase participates.

76 transfer of Araf to Hyp-arabinofuranotriose (Hyp-beta1,4Araf-beta1,2Araf-beta1,2Araf) side chains in

77 gen triple-helix stability in the absence of Hyp, biophysical studies were carried out on recombinant

78 pyrophosphate concentration is increased in Hyp bones, and that Tnap expression is decreased in Hyp-

79 m the pathogen Clostridioides difficile with Hyp bound in the active site.

80 terminal, central and C-terminal beta-l-Araf-Hyp building blocks.

81 was shown to carry Gal residues on isolated Hyp but also Ara residues.

82 eplacement of ProB28 by (4R)-hydroxyproline (Hyp) causes little change in the rates of fibrillation a

83 revealed hypomineralized "halos" surrounding Hyp cementocyte and osteocyte lacunae.

84 Formation of oversized Hyp clusters has been observed on the GUV surface at pro

85 he vesicle diameter and the buildup of large Hyp clusters in the GUV membrane.

86 neralization of the nasal septum in Mgp(-/-);Hyp compound mutants.

87 hree-dimensional solution structure of a Gla/Hyp-containing 18-residue conantokin, conRl-B, by high f

88 ional hydrogen-bonding capacity, the Pro-->2-Hyp conversion alters the active site and enhances signi

89 hepatitis; a contributory role of daclizumab HYP could not be excluded.

90 competition from PDH reduced anaplerosis in HYP+DCA by 18%.

91 Interestingly, reduced anaplerosis in HYP+DCA corresponded with normalized TAG (14.9+/-0.6 mic

92 ctivation: HYP=1419+/-220 nmol/g dry weight; HYP+DCA=343+/-56 nmol/g dry weight.

93 Recently, a GRE, trans-4-hydroxy-L-proline (Hyp) dehydratase (HypD), was discovered that catalyzes t

94 ovided insight into the radical mechanism of Hyp dehydration.

95 Hyp-derived osteocyte-like cells but not in Hyp-derived osteoblasts ex vivo and in vitro.

96 es, and that Tnap expression is decreased in Hyp-derived osteocyte-like cells but not in Hyp-derived

97 and decreased pyrophosphate concentration in Hyp-derived osteocyte-like cells in vitro.

98 The Hyp diastereomer (2S,4S)-4-hydroxyproline (hyp) has not

99 t and re-initiation group (300 mg daclizumab HYP) died because of autoimmune hepatitis; a contributor

100 Even though its product (Hyp) differs from its substrate (Pro) by only a single o

101 ween the hydroxyl moiety and the carbonyl of hyp distorts the main-chain torsion angles that typicall

102 o single-mutant littermates, compound-mutant Hyp/Dmp1(-/-) mice displayed nonadditive elevations of s

103 otype of compound Phex and Dmp1 mutant mice (Hyp/Dmp1(-/-)).

104 ind that the 4S-hydroxylation of Pro to form hyp does indeed enforce a C(gamma)-endo ring pucker but

105 riodicity: SOOOOKKHYVYKSOOOOVKHYSOOOVYH (O = Hyp), each repeat containing a hydrophobic isodityrosine

106 s conformation of the peptide bond preceding hyp, endowing hyp with the unusual combination of a C(ga

107 ive 150 mg or 300 mg subcutaneous daclizumab HYP every 4 weeks for 52 weeks (treatment initiation gro

108 Another isoform, HSSTnT hypothetical (Hyp) (-exon 5, +exon 12), has only been found at the mRN

109 The time evolution of Hyp fluorescence originating from Hyp monomers dissolved

110 lts support further assessment of daclizumab HYP for relapsing-remitting multiple sclerosis.

111 who received daclizumab high-yield process (HYP) for 52 weeks.

112 lphaKG)-dependent dioxygenases that catalyze Hyp formation.

113 peptide (denoted as the Hyp minus peptide or Hyp-) forms a rod-like triple helix structure without an

114 The incorporation of hypericin (Hyp) from aqueous solutions into giant unilamellar vesic

115 -radiolabeled fragment that co-eluted with a Hyp-Gal standard after high performance anion-exchange c

116 Examination of the Arabidopsis Hyp:GalT activity using various acceptor substrates, inc

117 tated as conserved HyP (9.5%) along with 887 HyP genes (24.4%).

118 Hypothetical (HyP) and conserved HyP genes account for >30% of sequenced bacterial genome

119 siRNA knockdown of human orthologs of the hyp genes conferred hypoxia resistance to transformed hu

120 The hyp genes had significant overlap with previously identi

121 Eighty-six per cent of these hyp genes had strong homologs in other organisms, 73 wit

122 croarray analysis identified a subset of the hyp genes that may be hypoxia regulated.

123 The hyp genes were distributed among multiple functional cat

124 e radial assembly, H-(byp)(2) containing Pro-Hyp-Gly repeating sequences and two staggered bipyridine

125 lix unit through sequential additions of Pro-Hyp-Gly triads, we achieved sub-angstrom tuning over the

126 folding in collagen peptides composed of Pro-Hyp-Gly triplet repeats, allowing for truncation to the

127 The two Pro-Hyp-Gly zones adopt the typical triple-helical collagen

128 h a sequence comprising a central block (Pro-Hyp-Gly) and two positively charged domains (Pro-Arg-Gly

129 After self-association, (Pro-Hyp-Gly)(10) forms branched filamentous structures, in c

130 The triple helical form of (Pro-Hyp-Gly)(10), a peptide that has proved a useful model f

131 amino acids on the self-association of (Pro-Hyp-Gly)(10).

132 Gly)3 and negatively charged C-terminal (Glu-Hyp-Gly)3 triad extensions, respectively.

133 (68)Ga-P03034 ((68)Ga-DOTA-dPEG2-Lys-Arg-Pro-Hyp-Gly-Cha-Ser-Pro-Leu) in B1R-positive (B1R+) HEK293T:

134 nd Z02090 ((68)Ga-DOTA-dPEG2-Lys-Lys-Arg-Pro-Hyp-Gly-Cpg-Ser-D-Tic-Cpg) derived from 2 potent B1R ant

135 ed P04158 ((68)Ga-DOTA-dPEG2-Lys-Lys-Arg-Pro-Hyp-Gly-Igl-Ser-D-Igl-Oic) and Z02090 ((68)Ga-DOTA-dPEG2

136 tere, Ac-(Gly-Pro-Hyp)3-Gly-psi[(E)CH C]-Pro-Hyp-(Gly-Pro-Hyp)4-Gly-Gly-Tyr-NH2, had a Tm value of 28

137 inofuranosylated hydroxyproline (beta-l-Araf-Hyp) glycocluster is described.

138 f modification, including Pro hydroxylation, Hyp glycosylation, and/or Tyr sulfation.

139 ted in 15% of the patients in the daclizumab HYP group and in 10% of those in the interferon beta-1a

140 nfections were more common in the daclizumab HYP group than in the interferon beta-1a group (in 65% v

141 ubstituent at the isonitrile, migration of a Hyp group was observed, resulting in two structurally si

142 HYP had elevated ME expression with a 90% elevation in a

143 As Hyp has a strong preference for C (gamma)- exo pucker an

144 e Hyp diastereomer (2S,4S)-4-hydroxyproline (hyp) has not been observed in a protein, despite the abi

145 In an automated manner, the Hyp hydroxyl is protected and the remainder of the pepti

146 on of the singlet biradical [P(mu-NHyp)](2) (Hyp = hypersilyl, (Me(3)Si)(3)Si) with different isonitr

147 ollagen peptide shows Phe interacts with Pro/Hyp in a neighboring triple-helical molecule.

148 ated this activity was specific for peptidyl Hyp in AGP sequences.

149 ensor makes it unique for easy estimation of Hyp in collagen and biological samples.

150 dress this disparity, as well as the role of Hyp in conantokins, we have solved the high resolution t

151 In contrast, the presence of Hyp in MVIIC had a significant impact on the oxidative f

152 In certain contexts, triple helices with Hyp in the Xaa position are now known to be hyperstable.

153 s have demonstrated that the presence of 3(S)Hyp in the Xaa positions of collagen-like peptides actua

154 or adding galactose (Gal) to hydroxyproline (Hyp) in AGP protein backbones.

155 vestigated the function of 4-hydroxyproline (Hyp) in conotoxins from three distinct gene families: mu

156 d calorimetry to explore the consequences of hyp incorporation on protein stability using a collagen

157 y-Asp-Lys motifs replaced Gly-Pro-Hyp (where Hyp is 4-hydroxy-L-proline) repeats.

158 Hyp is a major contributor to triple-helix stability in

159 Daclizumab high-yield process (HYP) is a humanized monoclonal antibody that binds to CD

160 he resulting product trans-4-hydroxyproline (Hyp) is of critical importance for the stability and thu

161 to be excellent substrates for P4H, forming Hyp, Kep, and (2 S,4 R)-thiaoxoproline, respectively.

162 yp mice was reversed to hyperphosphatemia in Hyp/klotho(-/-) double mutants, despite the fact that th

163 Moreover, in contrast to the Hyp mice, the Hyp/klotho(-/-) mice showed significantly higher serum l

164 Hyperphosphatemia in Hyp/klotho(-/-) mice was associated with increased renal

165 Furthermore, compared with the Hyp mice, Hyp/klotho(-/-) mice were smaller in size, showed featur

166 quently reduced serum levels of phosphate in Hyp/klotho(-/-) mice.

167 generated Hyp and klotho double-mutant mice (Hyp/klotho(-/-)).

168 ctan proteins partially defined by type II O-Hyp-linked arabinogalactans (Hyp-AGs) are structural com

169 or the trans-conformation in the order Pro < Hyp < [alpha-(1,4)GlcNAc]Hyp.

170 ved for Scl2 was similar to the contribution Hyp makes to the stability of mammalian collagens.

171 Hyp mandibles demonstrated expanded alveolar bone with a

172 3 levels and concomitant hypophosphatemia in Hyp mice and to evaluate whether FGF23 activity could be

173 Dentin in Hyp mice exhibited mineralization defects by 33 dpc, as

174 Such urinary phosphate wasting in Hyp mice is associated with an increased serum accumulat

175 le long bone and alveolar bone osteocytes in Hyp mice overexpressed fibroblast growth factor 23 (Fgf2

176 Hyp mice possess a mutation that inactivates the phospha

177 In vivo, bone-specific deletion of Fgf23 in Hyp mice rescued the suppressed TNAP activity in osteocy

178 Severe hypophosphatemia of Hyp mice was reversed to hyperphosphatemia in Hyp/klotho

179 of FGFR3 in mediating the effects of FGF23, Hyp mice were crossed with FGFR3-null mice; interestingl

180 Untreated Hyp mice were severely growth retarded and had marked al

181 also seen in another hypophosphatemic model (Hyp mice).

182 Hyp mice, a murine homologue of XLH, are characterized b

183 In contrast to Hyp mice, grip strength is preserved.

184 Furthermore, compared with the Hyp mice, Hyp/klotho(-/-) mice were smaller in size, sho

185 emia and reduced vitamin D hormone levels in Hyp mice, its putative role as an auto-/paracrine osteom

186 Moreover, in contrast to the Hyp mice, the Hyp/klotho(-/-) mice showed significantly

187 ecifically, we evaluated Cyp24 deficiency in Hyp mice, the murine homolog of X-linked dominant hypoph

188 Compared with wild-type mice, Hyp mice, which have elevated circulating levels of FGF2

189 h enamel volume was significantly reduced in Hyp mice.

190 2 protein in osteoblasts and osteocytes from Hyp mice.

191 ein in nuclear fractions from osteoblasts of Hyp mice.

192 regulating abnormal phosphate homeostasis in Hyp mice.

193 study molar tissues from wild-type (WT) and Hyp mice.

194 he aforementioned metabolic abnormalities of Hyp mice.

195 4 also failed to correct hypophosphatemia in Hyp mice.

196 recombinant soluble Klotho lowered BP in the Hyp mice.

197 he suppressed TNAP activity in osteocytes of Hyp mice.

198 contributing to the mineralization defect in Hyp mice.

199 fr3 mRNA in osteocytes versus osteoblasts of Hyp mice.

200 t in the teeth of X-linked hypophosphatemic (Hyp) mice.

201 gene and mutations in affected patients and hyp-mice established that alterations in PHEX/Phex expre

202 PhexDeltaflox/y, OC-Cre-PhexDeltaflox/y, and hyp-mice manifested comparable osteomalacia.

203 PhexDeltaflox/y, OC-Cre-PhexDeltaflox/y, and hyp-mice was likewise reduced compared with that in norm

204 PhexDeltaflox/y, OC-Cre-PhexDeltaflox/y, and hyp-mice were lower than those in normal mice.

205 te cotransporter protein, as was the case in hyp-mice.

206 The peptide (denoted as the Hyp minus peptide or Hyp-) forms a rod-like triple helix

207 Dentin defects in Hyp molars were indicated histologically by wide predent

208 ow the aggregation/dissociation processes of Hyp molecules in the membrane.

209 olution of Hyp fluorescence originating from Hyp monomers dissolved in the GUV membrane has been reco

210 We analyzed Hyp mouse dentoalveolar defects at 42 and 90 d postnatal

211 he first time a quantitative analysis of the Hyp mouse dentoalveolar phenotype, including all mineral

212 formation, a phenotype recapitulated in the Hyp mouse homolog.

213 d BP and significantly attenuated LVH in the Hyp mouse model of excess FGF-23, but did not induce a r

214 velopmental study of tooth root formation in Hyp mouse molars, focusing on dentin and cementum.

215 in the phosphate-regulating Phex gene of the Hyp mouse resulted in defective cementum development.

216 ether HMW FGF2 expression was altered in the Hyp mouse, a mouse homolog of the human disease X-linked

217 In the Hyp-mouse homologue of X-linked hypophosphatemic rickets

218 lineage cells, transgenic Phex expression in hyp-mouse osteoblasts fails to rescue the phenotype, sug

219 teocytes alone is sufficient to underlie the hyp-mouse phenotype.

220 with X-linked hypophosphatemia (XLH) and the hyp-mouse, a model of XLH characterized by a deletion in

221 sequences like (Gly-Pro-Pro)(n) or (Gly-Pro-Hyp)(n).

222 The existence of new type Hyp-O-Gal/Ara-rich motifs not recognized by the beta-glu

223 ls because arabinogalactans could be absent, Hyp-O-Gal/Ara-rich motifs of different sizes were observ

224 aa is often proline and Yaa, hydroxyproline (Hyp/O).

225 tural collagen, 3(S)-hydroxyl-L-proline (3(S)Hyp) occurs in the Xaa positions to varying extents and

226 ession was also suppressed in the RN, FC and HYP of females and RN of dominant pigs (P < 0.05).

227 oration of [(14)C]Gal from UDP-[(14)C]Gal to Hyp of model substrate acceptors having AGP peptide sequ

228 etramer in the ER, we discuss the effects of Hyp on the folding of conotoxins in the context of cis-t

229 year of continuous treatment with daclizumab HYP or during treatment washout and re-initiation.

230 ll autonomous increase in Fgf23 secretion in Hyp osteocytes drives the accumulation of pyrophosphate

231 54% lower number of lesions with daclizumab HYP; P<0.001).

232 .22 vs. 0.39; 45% lower rate with daclizumab HYP; P<0.001).

233 c-Myc expression was higher in Hyp/Pap and WDSCC but not PDSCC whereas MMP7 was reduced

234 plastic epidermis and/or squamous papilloma (Hyp/Pap), poorly-differentiated (PDSCC), or well-differe

235 EcPV2 infection in both NT and EpSCC but not Hyp/Pap.

236 blasts and/or osteocytes alone generates the HYP phenotype, we created mice with a global Phex knocko

237 Hyp (Phex mutant) mice recapitulate the XLH phenotype.

238 After peptide synthesis, the Hyp protecting group is orthogonally removed and Hyp sel

239 ed an invariant hypoxia-resistant phenotype (Hyp-r).

240 ly shared to create collagen destruction and Hyp release into both saliva and plasma.

241 of non-contiguous Hyp residues, such as (Ala-Hyp) repetitive units exemplified by chemically synthesi

242 de molecule to the C-terminal or penultimate Hyp residue of the [AO](7) peptide.

243 he varphi/psi dihedral angles of the Xaa 3(S)Hyp residues are also similar to those of typical collag

244 normal triple helical structure for Gly-Pro-Hyp residues flanking the break.

245 on of a stable triple helix, the role of 3(S)Hyp residues in the Xaa position is not well understood.

246 to determine what effect the presence of 3(S)Hyp residues in the Xaa positions has on the overall con

247 Although 4(R)Hyp residues in the Yaa positions have been shown to be

248 Given the high fraction of Pro and Hyp residues on the surface of collagen molecules, it is

249 amidoproline were overlaid with the Pro and Hyp residues within a crystal structure of collagen reve

250 romatic residues in the telopeptides and Pro/Hyp residues within the triple helix.

251 tide sequences, consisting of non-contiguous Hyp residues, such as (Ala-Hyp) repetitive units exempli

252 For GIIIA, which naturally contains three Hyp residues, the modifications improved the ability to

253 shows that, despite the presence of the 3(S)Hyp residues, the peptide still adopts a typical 7/2 sup

254 tive and powerful: it permitted us to locate Hyp residues, to demonstrate the presence of carbohydrat

255 The puckering of the Xaa position 3(S)Hyp residues, which are all down (Cgamma-endo), and the

256 h much more conformational stability than do hyp residues.

257 lpha1 chain of type I collagen containing no Hyp (residues 877-939) obtained from Escherichia coli.

258 The resulting (2 S,4 R)-4-hydroxyproline (Hyp) residues are essential for the folding, secretion,

259 The resulting (2S,4R)-4-hydroxyproline (Hyp) residues are essential for the folding, secretion,

260 oline (Pro) and 4(R)-hydroxyl-L-proline (4(R)Hyp) residues are found most frequently in the Xaa and Y

261 ommonly proline (Pro) and 4R-hydroxyproline (Hyp), respectively.

262 Among them, hydroxyproline (Hyp)-rich glycoproteins constitute a complex family of O

263 GPs) are highly glycosylated hydroxyproline (Hyp)-rich glycoproteins that are frequently characterize

264 expressed, secreted protein with homology to Hyp-rich cell wall proteins.

265 In this study, we characterized an atypical Hyp-rich glycoprotein, AGP31 (arabinogalactan protein 31

266 In contrast, the presence of the Hyp-rich sequence GPO(GAO)(3) N-terminal to the mutation

267 ally through substitution by hydroxyproline (Hyp), (S)-beta-homoproline (betaPro), 2-aminocyclopenten

268 In contrast, we found in HYP seizures that (1) fast ripple rates increased during

269 and region-specific patterns during LVF and HYP seizures, thus suggesting that they play specific ro

270 fast-onset (LVF) and hypersynchronous-onset (HYP) seizures in the rat pilocarpine model of temporal l

271 protecting group is orthogonally removed and Hyp selectively modified to generate substituted proline

272 nd with high affinity to tandem GPO (Gly-Pro-Hyp) sequences in collagen, whereas the markedly lower a

273 Hyp should prevent adoption of the metal ion-induced ful

274 HYP showed a 13% to 26% reduction in rate pressure produ

275 ing-remitting multiple sclerosis, daclizumab HYP showed efficacy superior to that of interferon beta-

276 A few extensin-like motifs with contiguous Hyp (SOOA and SOOT) were also found.

277 ncrease in Hyp and Dmp1(-/-) vs. 1.3-fold in Hyp+SU5402 and 2.5-fold in Dmp1(-/-)+SU5402, P<0.05).

278 respondingly, malate was 2.2-fold greater in HYP than SHAM but was lowered with PDH activation: HYP=1

279 lized relapse rate was lower with daclizumab HYP than with interferon beta-1a (0.22 vs. 0.39; 45% low

280 period of 96 weeks was lower with daclizumab HYP than with interferon beta-1a (4.3 vs. 9.4; 54% lower

281 function testing were higher with daclizumab HYP than with interferon beta-1a.

282 and growth plate and bone structure of young Hyp (the XLH animal model) mice.

283 discovered that catalyzes the dehydration of Hyp to (S)-Delta(1)-pyrroline-5-carboxylic acid (P5C).

284 O-Methylation of hyp to form (2S,4S)-4-methoxyproline (mop) eliminates th

285 se the multistep conversion of hypoxanthine (Hyp) to dGMP for DNA synthesis.

286 es (GF, GY) are present, and a rigid Gly-Pro-Hyp tripeptide adjacent to the interruption leads to gre

287 ns, identifying common residues such as Pro, Hyp, Tyr, and Ala.

288 o process is used to cleave the customizable Hyp unit under mild, metal-free conditions.

289 P) family, composed of tandemly repeated Pro-Hyp-Val-X-Lys pentapeptide motifs, is found primarily in

290 of other selected markers were disturbed in Hyp versus WT long bone, alveolar bone, and cementum, in

291 altered periodontal mechanical properties in Hyp versus WT mice.

292 cementum area was significantly increased in Hyp versus WT molars owing to accumulation of hypominera

293 Hyp was increased in saliva by the combined presence of

294 In a model tetrapeptide (Ac-TYPN-NH2), 4R-Hyp was stereospecifically converted to 122 different 4-

295 Most Hyp were isolated within repeated motifs such as KAOV, K

296 on group); those who had received daclizumab HYP were randomly assigned (1:1) to continue their prese

297 AMY), frontal cortex (FC), and hypothalamus (HYP) were dissected; relative mRNA abundance for 5-HT(B)

298 perated (SHAM) and aortic banded rat hearts (HYP) were perfused with buffer containing either 13C-pal

299 y-Asp or Gly-Asp-Lys motifs replaced Gly-Pro-Hyp (where Hyp is 4-hydroxy-L-proline) repeats.

300 of the peptide bond preceding hyp, endowing hyp with the unusual combination of a C(gamma)-endo ring