ライフサイエンスコーパス: IBAT

1 IBAT addresses this need by facilitating the production

2 batches and made an RM over the course of 10 IBAT iterations.

3 Oral, minimally absorbed IBAT inhibitors have been demonstrated to reduce serum b

4 roperitoneal and epididymal white tissue and IBAT, but skeletal muscle 2-DG uptake under the same con

5 CRFR2 revealed significantly elevated basal IBAT thermogenesis and prolonged adrenergic responsivity

6 pinephrine content of the interscapular BAT (IBAT) and the number of sympathetic ganglion cells proje

7 d receive SS inflow from, interscapular BAT (IBAT) in these separate studies suggesting SNS-SS feedba

8 sympathetically-mediated interscapular BAT (IBAT) thermogenesis.

9 espiration under conditions of low DeltaPsi (IBAT) but not high DeltaPsi (heart).

10 We found that succinate-energized IBAT mitochondria, even in the absence of ADP, accumulat

11 The indications for IBAT inhibitors will likely expand in the coming years a

12 tor-gamma-coactivator1-alpha (PGC-1alpha) in IBAT and increased UCP1protein expression; however, pero

13 Expression of GLUT4 was more abundant in IBAT and retroperitoneal fat from glucose- and fructose-

14 se or fructose, leading to SNS activation in IBAT and retroperitoneal fat and enhanced GLUT4 expressi

15 essential role in mediating the increase in IBAT thermogenesis induced by activation of central mela

16 The increases in IBAT SNA and in O(2) consumption were reversed by inhibi

17 roup of rats, the neural circuit involved in IBAT control, including the location of sympathetic preg

18 expression, or decreased UCP1 mRNA level in IBAT.

19 In addition, UCP1 mRNA levels in IBAT did not change with age.

20 summary, complex II-energized respiration in IBAT mitochondria is tempered by complex I-derived OAA i

21 ke in IBAT of the KE group was twice that in IBAT of the Ctrl group.

22 by contrast, decreased [(3)H]NE turnover in IBAT, but increased it in epididymal, though not retrope

23 [(18)F]-Fluorodeoxyglucose uptake in IBAT of the KE group was twice that in IBAT of the Ctrl

24 NH2; 0.024nmol) both significantly increased IBAT temperature (T(IBAT)) and pretreatment with the MC4

25 CL316,243 significantly increased IBAT temperature, afferent nerve activity, and c-Fos-IR

26 stalk by injecting both PRV152 and H129 into IBAT of Siberian hamsters.

27 developed iterative batch averaging method (IBAT).

28 the central nervous system (CNS) control of IBAT thermogenesis.

29 Pharmacological inhibition of IBAT with GSK2330672 may reduce BA levels in the systemi

30 lly linked to the sympathetic innervation of IBAT.

31 sis and prolonged adrenergic responsivity of IBAT in older mice.

32 published clinical and pre-clinical data on IBAT inhibitors and offer providers guidance on their pr

33 y c-Fos immunoreactivity (IR), we prelabeled IBAT DRG innervating neurons by injecting the retrograde

34 of MTII (1 nmol) significantly increased rat IBAT SNA (+741% of control).

35 R antagonist alone significantly decreased T(IBAT) up to 3h post injection.

36 locked the MC4-R agonist-induced increased T(IBAT) in conscious, freely-moving Siberian hamsters.

37 icle-treated hamsters initially maintained T(IBAT), but the ability of the former waned after 2 h bei

38 sters and, when they were adults, measured T(IBAT) during acute cold exposure.

39 reported to be involved in the control of T(IBAT).

40 ical increases in the duration and peak of T(IBAT).

41 nability of MSG-treated animals to sustain T(IBAT) in the cold is not due to any obvious MSG-induced

42 significantly increased IBAT temperature (T(IBAT)) and pretreatment with the MC4R antagonist, HS024

43 , although, interscapular BAT temperature (T(IBAT)) has not been measured.

44 g membrane transporter function by targeting IBAT/ASBT and NTCP, there is an array of potentially add

45 ear magnetic resonance (NMR) and showed that IBAT produces a stable and sustainable RM over time.

46 al design of future development phase of the IBAT inhibitor drug.

47 nover in interscapular brown adipose tissue (IBAT) and retroperitoneal fat increased in response to g

48 evels in interscapular brown adipose tissue (IBAT) from F344 x BN rats ages 3, 12, 18, 24, and 30 mon

49 ivity of interscapular brown adipose tissue (IBAT) in response to physiologic stimuli, such as cold e

50 ation in interscapular brown adipose tissue (IBAT) mitochondria, wherein DeltaPsi is intrinsically lo

51 lyses of interscapular brown adipose tissue (IBAT) thermogenesis by thermal signature analysis and th

52 n affect interscapular brown adipose tissue (IBAT) thermogenesis via its sympathetic nervous system (

53 scle and interscapular brown adipose tissue (IBAT) was investigated.

54 s, while interscapular brown adipose tissue (IBAT) weight doubled.

55 s in the interscapular brown adipose tissue (IBAT).

56 eased sympathetic nervous system activity to IBAT.

57 s of central sympathetic outflow circuits to IBAT, but appears to be extrinsic to the tissue neverthe

58 th components of the CNS outflow circuits to IBAT, with the latter implicated in BAT thermogenesis th

59 ons of MC4-R mRNA and SNS outflow neurons to IBAT that has not been previously reported to be involve

60 co-localization with SNS outflow neurons to IBAT, the subzona incerta (subZI) to test whether IBAT t

61 groups related to the sympathetic outflow to IBAT also were identified.

62 e for the increase in sympathetic outflow to IBAT during cold-evoked thermogenesis.

63 d-evoked increases in sympathetic outflow to IBAT, the present study compared central nervous system

64 a on the sympathetic nerve activity (SNA) to IBAT evoked by lateral ventricular injection of the mela

65 Ileal bile acid transporter (IBAT) inhibitors are a relatively new class of drugs whi

66 The ileal bile acid transporter (IBAT) protein expressed in the distal ileum plays a key

67 d importer, the ileal bile acid transporter (IBAT), as well as for CBATP.

68 ibitor of human ileal bile acid transporter (IBAT), in patients with primary biliary cholangitis with

69 he terminal ileum and proximal renal tubule (IBAT/ASBT inhibitors) and basolateral (sinusoidal) BA up

70 The results show that when IBAT mediates uptake of [3H]taurocholate to a level 20-f

71 the subzona incerta (subZI) to test whether IBAT thermogenesis could be increased or decreased.

72 was detected in COS cells cotransfected with IBAT and a chimeric molecule having the carboxyl-termina

73 acid efflux in COS cells cotransfected with IBAT and CEA, efflux of [3H]taurocholate was detected in