ライフサイエンスコーパス: ICU

1 ICU admissions occurred in 31% (95% CI, 26%-35%) of pati

2 ICU and ward physician predictions at the time of ICU di

3 ICU clinician perspectives on challenging aspects of car

4 ICU mortality was numerically higher in this group, alth

5 ICU mortality was significantly higher as compared with

6 ICU MRSA and C. difficile acquisitions per 1000 patients

7 77 patients (eight administrations per 1,000 ICU days); responder rate was 77%.

8 tory of granular data from more than 200,000 ICU admissions.

9 Three cohorts were defined as follows: 1) ICU survivors; 2) one-year survivors reporting newly-acq

10 s provided overnight coverage in four of 107 ICUs (4%).

11 We established contact with 122 ICU directors, of whom 107 (88%) responded.

12 cross the 3 hospitals, including 338 to 1608 ICU beds and 118 to 599 ventilators.

13 eight attending neurologists) evaluated 181 ICU patients; complete clinical and electroencephalograp

14 110 patients admitted to our adult COVID-19 ICUs, 28 patients required urgent exchange of their ETT.

15 ith use of PPIs and then use of H2RBs and 25 ICUs were randomized to the sequence with use of H2RBs a

16 equentially for 6 months in random order; 25 ICUs were randomized to the sequence with use of PPIs an

17 There were 83% hospital admissions, 25% ICU admissions, 23% intubations, and 13% deaths.

18 This study was conducted at 35 ICUs in 30 hospitals.

19 rom April 13 to April 24, 2020, including 48 ICU and 20 non-ICU patients, as well as 13 non-hospitali

20 Of 157,625 ICU patients, 20,916 (13.3%) had a fully defined treatme

21 andomized clinical trial was conducted in 65 ICUs in the United Kingdom and included 2600 randomized

22 natural history of cognitive recovery across ICU patient subgroups and determine which acute illness

23 ivists working 7+ consecutive days (adjusted ICU length of stay = 2.85 d), care by an intensivist wor

24 ation and its influence on severity-adjusted ICU mortality rate.

25 The age and illness severity of adult ICU trauma patients in Australia and New Zealand has inc

26 Adverse events are common after ICU discharge to hospital ward and are associated with I

27 ival declined over the first 5-10 days after ICU admission and changed little thereafter.

28 (18.1%) remained RRT dependent 60 days after ICU admission.

29 and 90 days, and greater than 90 days after ICU discharge, respectively; p < 0.001 for all compariso

30 both, diagnosed greater than 24 hours after ICU admission and confirmed by ultrasound, CT, or nuclea

31 ] vs. 35% [95% CI, 29-41%] at 3 months after ICU discharge) and when comprehensive cognitive batterie

32 %] vs. 36% [95% CI, 15-63%]; 12 months after ICU discharge: 43% [95% CI, 10-78%] vs. 18% [95% CI, 10-

33 primary endpoint was 28-day mortality after ICU admission.

34 e gradual alteration of mortality risk after ICU admission was assessed using left-truncation with in

35 on to ICU, and length of hospital stay after ICU discharge.Methods: Data were accessed from the Austr

36 All ICU patients admitted to and registered ICU nurses worki

37 Among ICU patients requiring mechanical ventilation, a strateg

38 ng-term cognitive impairment is common among ICU survivors, but its natural history remains unclear.

39 Physical and psychologic deficits after an ICU admission are associated with lower quality of life,

40 ge health care delivery resources to form an ICU survivor clinic care process and compare this new pr

41 Patients in an ICU are particularly vulnerable to sepsis.

42 me of admission and remain so 1 week into an ICU admission.

43 Prolonged admissions to an ICU are associated with high resource utilization and pe

44 ndrome-CoV-2 disease who were admitted to an ICU during the study period.

45 otal of 166,764 patients were admitted to an ICU in 2016 and 2017.

46 opioid-naive adults who were admitted to an ICU, received IMV, and survived at least 7 days after ho

47 and 51.5% (24/47) among those admitted to an ICU.

48 ere 263 patients who had been admitted to an ICU; at 6 months, 188 (73%) had died, 39 (15%) were depe

49 sensitivity analyses were conducted using an ICU cohort and Acute Physiology and Chronic Health Evalu

50 953 patients, 18 years old or older, with an ICU stay greater than 24 hours, who were on a ventilator

51 In multivariable analysis, ICU cohort had increased risk of any diagnosed mental di

52 atio per 1% increase, 1.010; p < 0.001), and ICU readmission (hazard ratios, 4.10, 4.17, and 1.82 for

53 0.03), longer hospitalization (p=0.015), and ICU stay at transplantation (p=0.029) were significantly

54 P = 0.007; OR, 6.91; 95% CI, 1.68-28.48) and ICU admission (P = 0.007; OR, 7.93; 95% CI, 1.75-35.69)

55 Hospitals, ICU directors, and ICU staff must devise strategies to overcome the modifia

56 insurance status, discharge disposition, and ICU drug exposures.

57 set was associated with shorter hospital and ICU stays, and shorter duration and need for mechanical

58 es of Clostridioides difficile infection and ICU and hospital lengths of stay were not significantly

59 stimates of past and projected inpatient and ICU cases of COVID-19 from February 4, 2020 to October 1

60 ted for within-ICU correlation, patient- and ICU-level covariates.

61 mmarizes all premorbid, illness-related, and ICU-related factors associated with sleep disruption in

62 elationship was seen between high strain and ICU mortality.

63 on the length of mechanical ventilation and ICU stay were only significant for the protocolized phys

64 vancomycin-resistant Enterococcus (VRE), and ICU-acquired bloodstream infections (UABSIs) for 1 189 1

65 ing and planning of health resources such as ICU beds.

66 We randomly assigned ICUs to either audit and feedback (intervention group) o

67 a patient's pre-ICU functional abilities at ICU admission, clinicians have a care coordination strat

68 d De Morton Mobility Index) were assessed at ICU awakening, ICU, and hospital discharge.

69 Impact Event Scale-Revisited assessed at ICU discharge has a good ability for the detection of pa

70 rd ratio, 2.00; p < 0.001), risk of death at ICU admission (hazard ratio per 1% increase, 1.010; p <

71 nts without pulmonary embolism (52%) died at ICU discharge (odds ratio 0.79 [0.24-3.26]; p = 0.99).

72 ialysis treatment, and with organ failure at ICU admission.

73 r the Functional Status Score for the ICU at ICU discharge was 0.80.

74 ility Index) were assessed at ICU awakening, ICU, and hospital discharge.

75 , and quality of life (Short Form-36) before ICU admission.

76 h of stay and death and are not predicted by ICU or ward physicians.

77 udy of adults admitted with shock to Calgary ICUs (June 2012-December 2018).

78 pressure response to fluid bolus in cardiac ICU patients was unpredictable with a poor relationship

79 emodynamic data from children in the cardiac ICU who received fluid bolus (10mL/kg of Ringers-Lactate

80 al/surgical ICUs, 59 (20.2%) were in cardiac ICUs.

81 As the pandemic continues, ICU clinicians anticipate a number of limited resources

82 ICU admission, and lasted from 1 to 30 days, ICU/hospital discharge.

83 l and mycologic data at admission and during ICU stay were collected in a database to evaluate variab

84 sed on clinical information available during ICU stay.

85 nd registered ICU nurses working at 15 Dutch ICUs between January 1, 2016, and January 1, 2018, were

86 Each ICU used each strategy sequentially for 6 months in rand

87 d specificity for predicting adverse events, ICU readmissions, and hospital death.

88 Self-reported minorities had fewer ICU admissions (p=0.03) and reduced hazard for mortality

89 eve respective accuracies of 73% and 74% for ICU care and ventilation.

90 ertheless, applying PP is time consuming for ICU staffs that are at risk of mental of physical exhaus

91 threshold (55, 60, 65, 70, and 75 mm Hg) for ICU-mortality.

92 strategy did not affect mortality, need for ICU admission, or ICU length of stay.

93 d sCD163 showed no association with need for ICU treatment; and (3) levels of sCD25, sTIM-3, and myel

94 r a novel interdisciplinary care process for ICU survivor care and their primary family caregivers, a

95 Readmission for ICU survivor care versus usual care: at 30 days (10.4% v

96 in the ICU include the optimal structure for ICU interprofessional team rounds; the importance of con

97 .73-0.93]) had the best predictive value for ICU mortality with cutoff values less than or equal to 1

98 coronavirus disease 2019, neither time from ICU admission to intubation nor high-flow nasal cannula

99 eriod between 1997 and 2016 to adult general ICUs in England, Wales, and Northern Ireland.

100 Overall, 12% of AGE inpatient cases had ICU stays and 2% died; 3 deaths were associated with C.

101 23; hemodynamic instability = 70%; hospital/ICU stay = 12 d; mortality = 14%) were transferred urgen

102 The need for hospitalization, ICU care, and mechanical ventilation were predicted with

103 Hospitals, ICU directors, and ICU staff must devise strategies to o

104 wed the pertinent literature to identify how ICU interprofessional team rounds can be optimized to in

105 number of limited resources that may impact ICU care including personnel, capacity, and surge potent

106 in resource-limited settings, it may improve ICU outcomes associated with opportune weaning.

107 trials assessing how biologics might improve ICU outcomes are direly needed.

108 er- and hypoglycaemia would remain common in ICU care despite standardised approaches to management.

109 sts that patient prognosis was considered in ICU admission, reducing healthcare load at a cost of dec

110 nomial model, only female gender and days in ICU with hyperinflammation were associated with pain.

111 Large decreases in ICU-acquired infections occurred across the UK ICU netwo

112 , CCL7 and CCL8, was particularly evident in ICU patients.

113 tal bed, appears safe and mostly feasible in ICU patients requiring continuous renal replacement ther

114 hysical function tests (Physical Function in ICU Test-scored and De Morton Mobility Index) were asses

115 $22,853-$28,224), driven by improvements in ICU free-days, vasopressor-free days, and ventilation-fr

116 Short-term mortality in ICU-admitted stroke patients was high with 30 days morta

117 cemic treatment targets improves outcomes in ICU.

118 A relative lower strain in ICU capacity as measured by bed census on the calendar d

119 also analyzed based on percentage of time in ICU.Measurements and Main Results: Of 57,550 decedents,

120 er nurse ratio with in-hospital mortality in ICUs.

121 n receiving cardiopulmonary resuscitation in ICUs had an initial rhythm of bradycardia and poor perfu

122 ethods: A prospective observational study in ICUs was conducted.

123 8) as being independently associated with in-ICU mortality.

124 nal team rounds can be optimized to increase ICU Liberation adherence.

125 h was included as a covariate and individual ICU as a random effect.

126 nd after intubation, PaCO2 after intubation, ICU length of stay, and short-term mortality.

127 CU Collaborative Research Database to larger ICUs with higher acuity.

128 ubgroup and enhanced in patients with longer ICU stay and lower Acute Physiology and Chronic Health E

129 ED length of stay (ED-LOS); ICU length of stay (ICU-LOS); hospital length of stay (H

130 m-related ICU admissions had a longer median ICU (2.4 d [1.2-4.6 d] vs 2.1 d [1.0-4.2 d]) and hospita

131 The median ICU length of stay was 1.57 days (interquartile range, 0

132 asured glomerular filtration rate in a mixed ICU population, with the lowest performance related to c

133 itiation.Methods: At seven multidisciplinary ICUs, 302 patients, aged >=40 years and requiring >=4 ho

134 up of hospitalized patients required neither ICU or hospital-requiring procedures, had a median lengt

135 ive care unit [ICU] admission or death vs no ICU admission or death).

136 April 24, 2020, including 48 ICU and 20 non-ICU patients, as well as 13 non-hospitalised, asymptomat

137 above the normal range in 16 (80%) of 20 non-ICU patients.

138 t a large fraction of deaths occurred in non-ICU patients.

139 use was slightly higher than for matched non-ICU patients (2.6% vs. 1.5%; adjusted odds ratio, 1.37 [

140 tensive care unit (ICU) or a specialised non-ICU COVID-19 floor in our hospital.

141 to be discharged home than other nonelective ICU patients.

142 incidences occurring at or above level 5 of ICU Mobility Scale (transfer to chair, marching in place

143 Sepsis from Clinical Data." It consisted of ICU patient data from three separate hospital systems.

144 Death within 28 days of ICU admission was similar in SOT and non-SOT patients (4

145 l fibrillation during the first four days of ICU admission.

146 atients, 133 (34.2%) died within 180 days of ICU admission.

147 h new organ failure over the first 7 days of ICU hospitalization independently of baseline organ fail

148 The duration of ICU stay was 7 (5-14) in the control group and 9 (5-20)

149 mpled using miniature BAL within 24 hours of ICU admission.

150 ial participants in rounds; the inclusion of ICU patients and their families in rounds-based discussi

151 uration of mechanical ventilation, length of ICU and hospital stays, and doses of sedative and analge

152 ic group, treatment intensity, and length of ICU stay.

153 Recommendations were categorized by level of ICU service to be applicable by setting, and grouped int

154 is room for improvement in the management of ICU-admitted severe asthma episodes.

155 examine relationships for three measures of ICU strain (bed census, severity-weighted bed census, an

156 Data show that family members of ICU patients may have high levels of anxiety, depression

157 outbreak trajectory, reducing the number of ICU beds needed at the peak by 48.4% (interquartile rang

158 The number of ICU patients cared for by each resident physician was hi

159 d by hemoglobin A1c obtained at the onset of ICU admission, has a significant effect on the relations

160 a significant effect on the relationship of ICU glycemia to mortality.

161 ions were found eligible (3,183 relatives of ICU patients).

162 The stop signal task results of ICU staff at two sites were compared for conventional (i

163 01-1.02) increased significantly the risk of ICU admission.

164 Status of ICU survivors was assess until 1 year after discharge.

165 nd ward physician predictions at the time of ICU discharge had low sensitivity and specificity for pr

166 The year of ICU admission was associated with significant decrease i

167 harge of patients with high risk of death on ICU admission.

168 patients who stayed longer than 48 hours on ICU.

169 -dimer, and greater severity of hypoxemia on ICU admission.

170 affect mortality, need for ICU admission, or ICU length of stay.

171 the secondary composite outcome of death or ICU length of stay greater than 48 hours, the risk model

172 ctors of death were old age and inpatient or ICU clinical setting.

173 surement generally began at randomization or ICU admission, and lasted from 1 to 30 days, ICU/hospita

174 ance, duration of mechanical ventilation, or ICU length of stay by timing of intubation.

175 Our ICU survivor care process results in decreased mortality

176 ere as follows: (1) severe clinical outcome (ICU treatment) was associated with high plasma levels of

177 ous complications, apneic time, oxygenation, ICU length of stay, or overall survival when used in the

178 was also no effect on postintubation PaCO2, ICU length of stay, or 28-day mortality.

179 ere admitted to one of the 335 participating ICUs between 2014 and 2015.

180 ) and cardiogenic shock within 48 hours post-ICU admission (odds ratio, 9.43; 1.77-50.12; p = 0.008)

181 l storm patients, 42% survived 6 months post-ICU admission.

182 Potential ICU sleep disruption risk factors were categorized into

183 rbidity (hazard ratio, 2.28; p < 0.001), pre-ICU physical dependence (hazard ratio, 2.00; p < 0.001),

184 65 years (hazard ratio, 1.30; p = 0.03), pre-ICU high comorbidity (hazard ratio, 2.28; p < 0.001), pr

185 inning with an assessment of a patient's pre-ICU functional abilities at ICU admission, clinicians ha

186 t 3 months post discharge, (2) return-to-pre-ICU functioning and residence at 6 months post discharge

187 s of patients who had an attending predicted ICU mortality of greater than 30% within the first 24 ho

188 also be ineffective in ultimately preventing ICUs from becoming overwhelmed and a subsequent second l

189 ay = 0.55; 95% CI, 0.37-0.80), but prolonged ICU- and hospital stays.

190 Background and Rationale: ICU clinicians regularly care for patients who lack capa

191 eening program does not significantly reduce ICU-acquired Pa infections in non-outbreak situations.

192 ic genomic sequencing of infants in regional ICUs.

193 All ICU patients admitted to and registered ICU nurses working at 15 Dutch ICUs between January 1, 2

194 On meta-regression, ICU admission was predicted by increased leukocyte count

195 Rapid response team-related ICU admissions had a longer median ICU (2.4 d [1.2-4.6 d

196 nce of preexisting comorbidities, and repeat ICU admission.

197 ronavirus disease 2019 patients, 30% require ICU care.

198 ed severe coronavirus disease 2019 requiring ICU care.

199 e outcome of the most severe forms requiring ICU admission.

200 erm clinical outcomes for patients requiring ICU care.

201 d in the Society of Critical Care Medicine's ICU Liberation Campaign, reviewed the pertinent literatu

202 he medical record within 7 days of patient's ICU discharge date to identify and classify adverse even

203 For each patient's ICU stay, we searched the chart for terms that indicated

204 consecutive days was associated with shorter ICU length of stay (3 consecutive days: 0.46 d fewer, p

205 length of stay (ED-LOS); ICU length of stay (ICU-LOS); hospital length of stay (HLOS); complications;

206 dy (NCT02267174) was conducted in 2 surgical ICUs in 2 affiliated hospitals.

207 ck, but only those from medical and surgical ICUs.

208 inappropriate antibiotic therapy in surgical ICUs, a statistically significant risk ratio of 2.59 was

209 years, 233 (79.8%) were in medical/surgical ICUs, 59 (20.2%) were in cardiac ICUs.

210 ved information exchange in 2 mixed surgical ICUs, with a concomitant increase in handoff duration.

211 Swedish ICU use rates remained lower than predicted, but a large

212 Every seventh patient in a Swiss ICU has some kind of treatment limitation, and this most

213 The ICU-Venous Thromboembolism score can identify patients a

214 -Revisited performed within 8 days after the ICU discharge to predict post-traumatic stress disorder

215 than the Confusion Assessment Method for the ICU (sensitivity = 41%, specificity = 88%, area under th

216 urve for the Functional Status Score for the ICU at ICU discharge was 0.80.

217 renal clearance remains challenging for the ICU physician.

218 uded the Confusion Assessment Method for the ICU, Intensive Care Delirium Screening Checklist, a focu

219 discharged home, 4 were discharged from the ICU but remained in the hospital, and 3 continued to rec

220 th functional outcome were assessed from the ICU subgroup.Measurements and Main Results: The study in

221 of stay, and were more likely to die in the ICU (12.3% vs 7.5%) and in-hospital (20.8% vs 13.5%) (p

222 ed (23.7%): thirty-five patients were in the ICU (47.9%) and 38 were not (52.1%).

223 ed focused on critically ill patients in the ICU and emergency department settings.

224 Conflict commonly occurs in the ICU around difficult and complex decision-making.

225 ly more immunocompetent patients were in the ICU at the time of diagnosis (21.0% vs. 8.6%, p = 0.024)

226 Similar results were observed in the ICU cohort.

227 Overnight physician staffing in the ICU has been recommended by the Society of Critical Care

228 fective interprofessional team rounds in the ICU include the optimal structure for ICU interprofessio

229 xfold from >=6 days' duration of stay in the ICU onwards.

230 tors associated with sleep disruption in the ICU setting.

231 ervative-oxygen group spent more time in the ICU with an Fio(2) of 0.21 than the usual-oxygen group,

232 Among patients in the ICU without ARDS who were expected not to be extubated w

233 ospitalized patients (excluding those in the ICU) whose condition reached the alert threshold at hosp

234 important in patients with cirrhosis in the ICU, however, there is limited data to guide therapies a

235 ute or acute on chronic liver failure in the ICU, related to five groups (cardiovascular, hematology,

236 In the ICU, we advocate for caution when using creatinine based

237 ociated with a shorter length of stay in the ICU, which supports the actual therapeutic transition; h

238 risk of new-onset atrial fibrillation in the ICU.

239 ued to receive mechanical ventilation in the ICU.

240 approach to glucose control practices in the ICU.

241 for a common and important condition in the ICU.

242 tors associated with sleep disruption in the ICU.

243 r HAP was associated with a reduction of the ICU length of stay.

244 As compared to the baseline period, the ICU length of stay was reduced by 3.2 days in the interv

245 mpensated cirrhosis who were admitted to the ICU between March 2015 and March 2017.

246 A total of 27 patients were admitted to the ICU for coronavirus disease 2019 out of 1,788 severe acu

247 irectly from the emergency department to the ICU from January 1, 2003, to October 1, 2015, were evalu

248 imilar, but 55% (24/43) were admitted to the ICU in 2017 compared to 12% in preceding 3 years (odds r

249 avirus disease 2019 patients admitted to the ICU were included in the analysis.

250 esults: Thirty-five patients admitted to the ICU with severe influenza and pulmonary aspergillosis we

251 tage kidney disease patients admitted to the ICU.

252 t in patients with cirrhosis admitted to the ICU.

253 istress syndrome, requiring admission to the ICU.

254 Secondary endpoints were the ICU length of stay and the 28-day all-cause mortality.

255 gagement in care of the patient during their ICU stay.

256 ormed to assess the impact on ED dwell time, ICU and hospital lengths of stay, complications, and in-

257 Six predictors of admission to ICU were found in multivariable analysis, including dise

258 patients have been more commonly admitted to ICU than can be explained solely by the demographic shif

259 nancies admitted to hospital are admitted to ICU.

260 Standardizing OR to ICU handoffs improves information transfer after cardiac

261 Standardizing OR to ICU handoffs significantly improved information exchange

262 including hospital mortality, readmission to ICU, and length of hospital stay after ICU discharge.Met

263 All survived to ICU admission.

264 ving burnout prevention programs targeted to ICU physicians, advanced practice providers, and nurses.

265 Two ICU physicians independently reviewed progress and consu

266 U-acquired infections occurred across the UK ICU network linked with the first few years of a nationa

267 outcome was defined as intensive care unit (ICU) admission or death.

268 duration of stay in an intensive care unit (ICU) and increased number of leukocytes in the pancreati

269 r pairs admitted to the intensive care unit (ICU) due to severe COVID-19.

270 atients admitted to the intensive care unit (ICU) for COVID-19-related acute respiratory failure were

271 llowing admission to an intensive care unit (ICU) for respiratory or cardiovascular organ support at

272 entified in the medical intensive care unit (ICU) or a specialised non-ICU COVID-19 floor in our hosp

273 Intensive care unit (ICU) patients or patients requiring mechanical ventilati

274 physicians during their intensive care unit (ICU) rotations: extended-duration work schedules that in

275 ho were admitted to the intensive care unit (ICU) with confirmed infection with severe acute respirat

276 e to discharge from the intensive care unit (ICU), and 1-year survival.

277 on of care from ward to intensive care unit (ICU), new requirement for mechanical ventilation, and mo

278 The national impact on intensive care unit (ICU)-acquired infections has not been documented.

279 e and mortality, and on intensive care unit (ICU)-bed occupancy.

280 n = 30) admitted to the intensive care unit (ICU).

281 rophylaxis drugs in the intensive care unit (ICU).

282 an available bed in the intensive care unit (ICU).

283 atients admitted to the intensive care unit [ICU; n=5]).

284 versus patient outcome (intensive care unit [ICU] admission or death vs no ICU admission or death).

285 orders on admission to intensive care units (ICUs) among 106,873 patients in the United States.

286 h COVID-19 admitted to intensive care units (ICUs) at 67 hospitals across the United States.

287 xtensive monitoring in intensive care units (ICUs) generates large quantities of data which contain n

288 ecember 17, 2019, in 8 intensive care units (ICUs) in the Netherlands among 980 patients without ARDS

289 Hospital beds, intensive care units (ICUs), and ventilators are vital for the treatment of pa

290 In five intensive care units (ICUs), we enrolled conscious, critically ill adults who

291 utcomes of patients in intensive care units (ICUs).

292 patients especially in intensive care units (ICUs).

293 han Mini-Mental State Examination were used (ICU discharge: 61% [95% CI, 38-100%] vs. 36% [95% CI, 15

294 We included mechanically ventilated ICU patients who were given moderate-to-high doses of op

295 rst-case scenarios except the highest-volume ICU scenario, inter-regional transfers could fully resol

296 these trials, the outcomes of interests were ICU length of stay, vasopressor-free days, ventilation-f

297 Of note, male gender was not associated with ICU mortality (OR 1.08 95%CI 0.98-1.19; p = 0.14).

298 rge to hospital ward and are associated with ICU readmission, increased hospital length of stay and d

299 ty was significantly higher as compared with ICU control group non-end-stage kidney disease (25% vs 4

300 Models were adjusted for within-ICU correlation, patient- and ICU-level covariates.