ライフサイエンスコーパス: IDR

1 IDR is also an open source platform that others can use

2 IDR links data from several imaging modalities, includin

3 IDR-1002 also dampened the IFN-gamma response and repres

4 IDR-1018 is effective in the brain when given systemical

5 IDR-1018 reduced inflammatory mediators produced by LPS-

6 IDR-1018 selectively attenuated hyperinflammatory cytoki

7 IDR-1018 suppresses proinflammatory mediators and cell i

8 IDRs were then assessed for their ability to confer neur

9 complications by >3-fold (23.5% versus 7.0%, IDR 3.4 [95% CrI 3.0-3.8]).

10 than the innate-defence regulator IDR-1018 (IDR).

11 phosphotyrosine-containing sequence, pY(173)IDR, does not conform to the canonical recognition motif

12 The anti-inflammatory effects of 3 IDRs was measured in lipopolysaccharide (LPS)-activated

13 variation across hospitals for STAT 1 to 3 (IDR 3.0 [95% CrI 2.1-4.2]) and STAT 4 or 5 (IDR 3.1 [95%

14 (IDR 3.0 [95% CrI 2.1-4.2]) and STAT 4 or 5 (IDR 3.1 [95% CrI 2.4-3.9]) cases.

15 ays [IQR 63-303] vs 139.5 days [63.0-309.5]; IDR 0.84 [95% CI 0.51-1.38]), or time to first readmissi

16 (upper versus lower decile 5.0% versus 1.6%, IDR 3.1 [95% CrI 2.5-3.7]), mean length of stay by 1.8-f

17 genetic platform that uses light to activate IDR-mediated phase transitions in living cells.

18 While all IDR were highly conserved among both seropositive and HI

19 This relaxed structure allows IDRs, which are implicated in the regulation of transcri

20 antly, the molecular understanding of how an IDR-rich protein works in an essential partnership with

21 distribution of timescales of motions in an IDR from picoseconds to nanoseconds.

22 These were based on fusions of an IDR derived from the RNA granule protein FUS (fused in s

23 change by NMR to investigate the state of an IDR that folds upon binding through the observation of t

24 d isolated ID3 transiently interacts with an IDR of ZFP106 in a fashion that disorder of both regions

25 th synthetic host-defense peptides DJK-5 and IDR-1018 under host-like conditions and in a murine absc

26 F cell transcriptional responses to FliC and IDR-1018 identified dysfunctional autophagy as the targe

27 ace carbohydrate and JAM-A by the length and IDR mutant viruses.

28 lm inhibiting concentrations, whereas TL and IDR are consistently less effective.

29 bactericidal effect at 5 x MIC, while TL and IDR require higher concentrations.

30 To understand how folded domains and IDRs can cooperate to modulate LLPS, we generated a seri

31 i.e. entirely lack structural elements, and IDRs as regions that are at least five consecutive resid

32 prevalence and functional roles of IDPs and IDRs associated with the release and recycling of synapt

33 IDPs and IDRs constitute a class of proteins and protein regions

34 per fundamental characterization of IDPs and IDRs for discovering new functions and relevant mechanis

35 dered proteins and protein regions (IDPs and IDRs, respectively) in synaptic vesicle trafficking and

36 ids discovery of novel functions of IDPs and IDRs.

37 Expression of the APC IDR in colorectal cells promotes Axin puncta formation a

38 The sequence features of the Ash1 IDR are shared by many other IDRs that undergo multisite

39 We show that the unphosphorylated Ash1 IDR adopts coil-like conformations that are expanded and

40 s located at the C-terminal region of AtWRI1(IDR) (3).

41 sphorylation of the PEST motif in the AtWRI1(IDR) (3) domain may affect AtWRI1-mediated plant oil bio

42 other studies, localize the TPO autoantibody IDR to the junction of the CCP-like domain and the much

43 he putative location of the TPO autoantibody IDR.

44 Some interactions between IDRs and folded protein domains rely on short linear mot

45 ions to allow for a localized LLPS driven by IDRs on RNA binding proteins.

46 ions and specificity of function mediated by IDRs.

47 fically, although the SLiM was surrounded by IDRs, individual intrinsic alpha-helix propensities vari

48 C-IDR phosphorylation shifts the conformational equilibriu

49 -terminal intrinsically disordered region (C-IDR), remaining disordered after phosphorylation, contai

50 study we probed the function of the central IDR.

51 These results show that low-complexity IDRs can modulate LLPS both positively and negatively, d

52 scontinuity were associated with compulsion (IDR 0.973 [95% CI 0.96-0.99, p<0.0001].

53 uster that binds an evolutionarily conserved IDR within the metazoan TFIID transcription complex.

54 water versus POU-treated water consumption (IDR = 1.52; 95% CI: 1.05, 2.20), but there was no associ

55 Extending previous data, IDR-1002 suppressed in vitro inflammatory responses in R

56 of stay by 1.8-fold (19.2 versus 10.5 days, IDR 1.8 [95% CrI 1.8-1.9]), and major complications by >

57 an arginine-to-lysine (RtoK) mutant of Ddx4 IDR.

58 nd nonspecific image analysis, we determined IDRs of a diverse set of substances from individual pure

59 as been a long-standing enigma how different IDRs successfully execute their specific functions.

60 d evolution, we focused on a highly diverged IDR in Saccharomyces cerevisiae that is involved in regu

61 How do IDR sequences modulate the functionalities of motifs?

62 gests a new avenue for targeting the elusive IDRs by harnessing certain features of metal-based compl

63 gm for IDR function is that disorder enables IDRs to adopt multiple conformations, expanding the abil

64 ooks that allows remote access to the entire IDR.

65 any transcription factors via their flexible IDRs.

66 One current paradigm for IDR function is that disorder enables IDRs to adopt mult

67 ristics based on amino acid compositions for IDRs with low proline contents.

68 s an unanticipated multi-functional role for IDRs in regulating both facilitated diffusion on chromat

69 This article formulates IDR prediction as a sequence labeling problem and employ

70 The human homolog of Ubp10, USP36, also has IDRs flanking its catalytic domain, and these IDRs simil

71 gths were incorporated into a synthetic HDP, IDR-1018, and the impact of these substitutions on the a

72 When administered 3 hours after LPS+HI, IDR-1018 exerted effects on regulatory molecules of apop

73 -separated candidate proteins exhibit higher IDR contents, higher mean net charge and lower hydropath

74 gle-molecule biophysics, we characterize how IDRs regulate the functions of the yeast MutLalpha (Mlh1

75 x is an excellent example to demonstrate how IDRs and SLiMs govern communication between four differe

76 sensitivity to various doses of idarubicin (IDR), daunorubicin (DNR), or mitoxantrone (MTA) gave the

77 NMR experiments to get a snapshot of an IDP/IDR in conditions approaching physiological ones.

78 to collect simultaneous snapshots of an IDP/IDR through different two-dimensional spectra provides a

79 mbraneless biomolecular condensates and IDPs/IDRs are functionally involved in key cellular processes

80 icate specific types of condensates and IDPs/IDRs in important cellular level processes and molecular

81 of which are organized or regulated by IDPs/IDRs, can enable spatial and temporal regulation of comp

82 dynamic information on highly flexible IDPs/IDRs.

83 pproach is generally applicable to many IDPs/IDRs whose assignment is available in the Biological Mag

84 s subsequently developed for studies of IDPs/IDRs and applied to the dilute phase of a 103-residue di

85 erization and functional annotations of IDPs/IDRs, and is intended to provide an invaluable resource

86 information on more than 800 entries of IDPs/IDRs, i.e. intrinsically disordered proteins or regions

87 structural and dynamical information on IDPs/IDRs, and recent efforts have focused on the development

88 rinsically disordered proteins/regions (IDPs/IDRs) are proteins or peptide segments that fail to form

89 rinsically disordered proteins/regions (IDPs/IDRs) contribute to a diverse array of molecular functio

90 ically disordered proteins and regions (IDPs/IDRs) that do not adopt a dominant well-folded structure

91 and the frequency of "sticky" amino acids in IDRs (those more frequently involved in protein interfac

92 Strikingly, these proteins are enriched in IDRs and contribute significantly to all the observed tr

93 ngs highlight the importance of mutations in IDRs and refine the traditional structure-centric view o

94 demonstrate that 20% of disease mutations in IDRs cause local disorder-to-order transitions, which re

95 ion about the impact of disease mutations in IDRs.

96 to which the properties of, and content in, IDRs have adapted to enable functional diversity while l

97 Initiator IDRs are shown to regulate multiple functions, including

98 Using this integration, IDR facilitates the analysis of gene networks and reveal

99 increases the likelihood of long-range intra-IDR interactions that involve both the primary and auxil

100 The binodals of LAF-1 and its IDR display a number of unusual features, including 'hig

101 S-1 cells is associated with cleavage of its IDR, conceivably to prevent its aggregation upon exposur

102 by a low-complexity poly-K region within its IDR.

103 ultiple, distinct binding modules within its IDRs that are necessary and sufficient for directing pro

104 IDRs), the N-terminal IDR and central-linker IDR, as well as the folded C-terminal oligomerization do

105 e and currently a major challenge is linking IDRs to their biological roles from the molecular to the

106 libraries, which demonstrated that the long IDR linking the KIX domain and bromodomain of CBP (terme

107 Most IDR prediction methods use sequence profile to improve a

108 ur data support a model whereby nascent NepR(IDR)-PhyR interactions and REC phosphorylation coordinat

109 ositively or negatively) these activities of IDR-1018.

110 , our results demonstrate that AS control of IDR-mediated interactions between hnRNPs represents an i

111 by means of which real-time determination of IDR from continuously changing effective surface areas o

112 matory and autophagosome-clearing effects of IDR-1018, as did a chemical inhibitor of Akt and an acti

113 aromatic amino acids, favoring formation of IDR structures.

114 estigate the anti-inflammatory mechanisms of IDR-1002 in vivo, the PMA-induced mouse ear inflammation

115 creation of enzymatically stable mimetics of IDR-1018 and identify a promising new cyclic analogue ag

116 ope to show that nanocompartmentalization of IDR subdomains leads to a remarkably elaborate gating st

117 protein interaction scaffolding abilities of IDRs in the regulation of dynamic protein ubiquitination

118 Over time, sequence-based classifiers of IDRs have become fairly accurate and currently a major c

119 DR content and the amino acid composition of IDRs experience negative selection as the protein concen

120 harge patterning on the global dimensions of IDRs.

121 ts that connect sequence-derived features of IDRs to their conformations, propensities to form biomol

122 as state of the art in the identification of IDRs, and our self-assessment shows that it significantl

123 Two key properties of IDRs are (i) the occurrence is proteome-wide and (ii) th

124 To examine the roles of IDRs in CBP, we performed yeast-two-hybrid screenings of

125 est that the primary amino acid sequences of IDRs encode a variety of their interaction behaviors.

126 fferent classes of experiment for studies of IDRs or IDPs in both dilute and phase-separated environm

127 Further putting a spotlight on IDRs are recent discoveries of functionally relevant bio

128 pothesis, we find that diverged, orthologous IDRs can mostly recapitulate wild-type function and fitn

129 ection, the functional output of orthologous IDRs could be maintained, such that diverse genotypes co

130 e functionalities of primary motifs in other IDRs.

131 res of the Ash1 IDR are shared by many other IDRs that undergo multisite phosphorylation.

132 our findings might be generalizable to other IDRs involved in cell signaling.

133 Our experimental results show that our IDR prediction method AUCpreD outperforms existing popul

134 thereby counterbalancing the loss in overall IDR conformational entropy upon binding.

135 erminal intrinsically disordered region (p27 IDR) of the cell cycle inhibitory protein p27(Kip1).

136 phorylation of Thr-187 (T187) within the p27 IDR controls entry into S phase of the cell division cyc

137 ver cryptic sequence features within the p27 IDR that influence the efficiency of T187 phosphorylatio

138 re, we designed sequence variants of the p27 IDR to alter charge patterning outside the primary subst

139 Wild-type p27 IDR (kappa31) and kappa14, where the oppositely charged

140 ross section distributions for wild-type p27 IDR and two variants with identical amino acid compositi

141 e charge patterning within the wild-type p27 IDR may be optimized to sample both highly solvated and

142 the cryptic sequence features of the WT p27 IDR negatively regulate T187 phosphorylation signaling.

143 In particular, IDRs of multi-functional proteins feature more sticky am

144 ntibiofilm innate defense regulator peptide (IDR)-1018 based on three different synthetic strategies

145 ential of innate defense regulator peptides (IDRs) was investigated.

146 conformational properties of polyampholytic IDRs are governed as much by linear charge patterning as

147 ubiquitinating enzyme, Ubp10, that possesses IDRs flanking its catalytic protease domain.

148 h makes it challenging to accurately predict IDRs.

149 its predecessor with new modules to predict IDRs and protein-binding sites within them.

150 Predicted IDRs are annotated as protein binding through a novel SV

151 Results reveal that both the protein IDR content and the frequency of "sticky" amino acids in

152 insic disorder in otherwise folded proteins (IDRs) play important roles in many different biological

153 nsically disordered regions within proteins (IDRs) serve an increasingly expansive list of biological

154 Targeting PTEN IDR and its interaction hubs emerges as a new paradigm f

155 ension of the Irreproducible Discovery Rate (IDR) method called IDR2D that identifies replicable inte

156 Intrinsic dissolution rate (IDR) has traditionally been determined from a constant s

157 had increased GII [incidence density ratio (IDR) = 1.34; 95% CI: 1.00, 1.79].

158 ion was quantified by the interdecile ratio (IDR, upper versus lower 10%) and 95% credible intervals

159 1.91] vs 2.2 [1.43]; incident density ratio [IDR] 0.97 [95% CI 0.76-1.24]), duration of readmissions

160 s an acidic intrinsically disordered region (IDR) and a protease-like SprT domain.

161 y which its intrinsically disordered region (IDR) at the carboxyl-terminus (C-tail) executes its func

162 ntified the intrinsically disordered region (IDR) at the N-terminal domains of OsDGAT1 proteins.

163 600-amino acid intrinsic disordered region (IDR) both directs cyclin C-Cdk8 association and serves a

164 posed of an intrinsically disordered region (IDR) followed by a highly conserved amphipathic alpha-he

165 nd that the intrinsically disordered region (IDR) of APC, which contains multiple beta-catenin and Ax

166 N-terminal intrinsically disordered region (IDR) of DEAD-box helicase Ddx4, as a test case, to asses

167 PhyR and an intrinsically disordered region (IDR) of the anti-sigma factor, NepR, by solution NMR spe

168 The intrinsically disordered region (IDR) on MBD2 both reduces exchange between mCpG sites al

169 omprises an intrinsically disordered region (IDR) that facilitates its liquid-liquid phase separation

170 code for an intrinsically disordered region (IDR), which in vitro acts as a condensing factor for the

171 within the intrinsically disordered region (IDR), which is the region for compaction of chromatin in

172 ly evolving intrinsically disordered region (IDR).

173 D2IDR is an intrinsically disordered region (IDR).

174 omain by an intrinsically disordered region (IDR).

175 y were 100% with both immunodominant region (IDR) and V3 region MAPs.

176 gely restricted to an immunodominant region (IDR) on the extracellular region of the native molecule.

177 PR) is an intrinsically unstructured region (IDR).

178 ons in the intrinsically disordered regions (IDR) of EloA interfere with its targeting and localizati

179 directed against the immunodominant regions (IDR) of HIV-1 structural proteins.

180 by intrinsically disordered protein regions (IDR) of RNA binding proteins in vitro have the opposite

181 ally disordered proteins (IDPs) and regions (IDRs) in the human proteome together with their lack of

182 ally disordered proteins (IDPs) and regions (IDRs), which represent approximately 30% of the proteome

183 nriched in intrinsically disordered regions (IDRs) and acidic stretches.

184 including intrinsically disordered regions (IDRs) and prion-like domains, such characteristics are i

185 Intrinsically disordered regions (IDRs) are characterized by their lack of stable secondar

186 Intrinsically disordered regions (IDRs) are often fast-evolving protein domains of low seq

187 Intrinsically disordered regions (IDRs) are present in at least 30% of the eukaryotic prot

188 oteins and intrinsically disordered regions (IDRs) are ubiquitous in the eukaryotic proteome.

189 mploys the intrinsically disordered regions (IDRs) from a family of phenylalanine-glycine-rich nucleo

190 omains and intrinsically disordered regions (IDRs) having low amino acid sequence complexity.

191 ized three intrinsically disordered regions (IDRs) in Arabidopsis WRI1, and found that one C-terminal

192 e distinct intrinsically disordered regions (IDRs) in G3BP1 regulates its intrinsic propensity for LL

193 teins have intrinsically disordered regions (IDRs) in their C-terminal domains and that these regions

194 as well as intrinsically disordered regions (IDRs) of complex protein machineries have recently been

195 ded within intrinsically disordered regions (IDRs) of proteins are often the sites of posttranslation

196 s encoding intrinsically disordered regions (IDRs) of proteins, in particular those containing glycin

197 line where intrinsically disordered regions (IDRs) of SRRM2 are genetically deleted, leads to a near-

198 y occur in intrinsically disordered regions (IDRs) of transcription factors (TFs).

199 onsists of intrinsically disordered regions (IDRs) of varying length.

200 Protein intrinsically disordered regions (IDRs) play an important role in many biological processe

201 Intrinsically disordered regions (IDRs) play important roles in proteins that regulate gen

202 onsists of intrinsically disordered regions (IDRs) that do not fold into well-defined 3D structures y

203 t1 contain intrinsically disordered regions (IDRs) that drive LLPS and constitute a new class of phas

204 ddress the intrinsically disordered regions (IDRs) that typically flank the core as well as the small

205 use their intrinsically disordered regions (IDRs) to enter and concentrate in Mediator condensates a

206 quires two intrinsically disordered regions (IDRs), the N-terminal IDR and central-linker IDR, as wel

207 ns contain intrinsically disordered regions (IDRs), which act in unfolded states or by undergoing tra

208 extensive intrinsically disordered regions (IDRs), which are conformationally plastic and do not app

209 d by large intrinsically disordered regions (IDRs).

210 on through intrinsically disordered regions (IDRs).

211 flexible linkers termed interdomain regions (IDRs).

212 cally disordered proteins (IDPs) or regions (IDRs) perform diverse cellular functions, but are also p

213 cally disordered proteins (IDPs) or regions (IDRs).

214 ordered proteins (IDPs) and protein regions (IDRs) engage in transient, yet specific, interactions wi

215 by intrinsically disordered protein regions (IDRs) have emerged as a ubiquitous mechanism for assembl

216 Intrinsically disordered protein regions (IDRs) lack a well defined three-dimensional structure bu

217 by intrinsically disordered protein regions (IDRs) that undergo multisite Serine/Threonine phosphoryl

218 ordered proteins (IDPs), or protein regions (IDRs), are modulated by the nature of amino acid side ch

219 effective than the innate-defence regulator IDR-1018 (IDR).

220 Innate defense regulator (IDR) peptide-1002 is a synthetic host defense peptide de

221 changes induced by innate defense regulator (IDR)-1018, an anti-inflammatory peptide.

222 e conformational properties of an 81-residue IDR from the S. cerevisiae transcription factor Ash1.

223 s, we built a prototype Image Data Resource (IDR) that collects and integrates imaging data acquired

224 amino acid usage is typical of proline-rich IDRs.

225 Together these results indicate that Cdc15's IDR has a nonredundant essential function that coordinat

226 interaction network, the higher a protein's IDR content, the more frequently it interacts with IDR-c

227 y driven by weak, multivalent, but selective IDR-IDR interactions.

228 nal interactions, commonly mediated by short IDR segments, thereby counterbalancing the loss in overa

229 Mlh1-Pms1 complexes with shorter IDRs that disrupt MMR retain wild-type DNA binding affin

230 nd deleted midpoint and head-proximal sigma1 IDRs to generate DeltaIDR1 and DeltaIDR2 mutant viruses,

231 , but recent studies have shown that similar IDRs mediate specific and critical interactions in other

232 cted through cross-reactivity with other SIV IDR MAPs used in the assay.

233 cipants to their POU water treatment status (IDR = 0.98; 95% CI: 0.90, 1.08).

234 r recognition features present in the C-tail IDR enhance PTEN's protein-protein interactions that are

235 emanate from and are nucleated by the C-tail IDR, which form pliable network-hubs.

236 P-IDP interactions facilitated by its C-tail IDR.

237 folded N-terminal domain and the C-terminal IDR are not required.

238 (NTD) of FIP200 interact with the C-terminal IDR of ATG13.

239 bidopsis WRI1, and found that one C-terminal IDR of AtWRI1 (IDR3) affects the stability of AtWRI1.

240 question using the polyampholytic C-terminal IDR of the cell cycle inhibitory protein p27(Kip1) (p27)

241 ly disordered regions (IDRs), the N-terminal IDR and central-linker IDR, as well as the folded C-term

242 Zs to other bacterial proteins with tethered IDRs.

243 We present a molecular classification of TF IDRs, which provides a framework to dissect TF function

244 roteins feature more sticky amino acids than IDRs of their non-multifunctional counterparts, or the s

245 This study demonstrates that IDR-1002 exhibits strong in vitro and in vivo anti-infla

246 on the mouse ear transcriptome revealed that IDR-1002 reduced sterile inflammation by suppressing the

247 We highlight new evidence suggesting that IDRs are often critical for histone chaperone function a

248 induces DNA bending that is augmented by the IDR region of the protein.

249 rT domain is needed to limit DNA damage, the IDR imparts significant function.

250 y disordered region, we sought to delete the IDR to study the functional significance of calcium-depe

251 rather than the smaller region encoding the IDR.

252 heterologous proteins can substitute for the IDR and the hA helix of human thymidylate synthase, indi

253 n simply as an extension or scaffold for the IDR; rather, it provides a specific structural component

254 It has been a long-standing mystery how the IDR-mediated mass exchange can be rapid yet selective.

255 ted by flexible, hydrophilic segments in the IDR as a key determinant of TDP43 phase properties.

256 h a prevalence of motions around 1 ns in the IDR.

257 Although the construct lacking the IDR (DeltaIDR prestin) demonstrated wildtype-like nonlin

258 Localization of the IDR has been a longstanding and difficult goal.

259 nging: in solution-state NMR, signals of the IDR in the interacting region become broad, weak, and of

260 so find that the electrostatic charge of the IDR is correlated with signaling output and, using phylo

261 esidues in Gly/Ser-Tyr-Gly/Ser motifs of the IDR reduced this effect, depending on the number but not

262 Deleting part of the IDR results in CR defects and abolishes calcineurin phos

263 conformation of the interacting part of the IDR was determined and subsequently docked onto the stru

264 Furthermore, the tryptic stability of the IDR-1018 derivatives was assessed revealing that proteol

265 otein partner lead to partial folding of the IDR.

266 embrane EGF-like domain as being part of the IDR.

267 non-aromatic residues or phosphorylating the IDR raised the phase separation threshold above that of

268 CA512 RESP18HD residues 35-90, preceding the IDR, inhibit insulin fibrillation in vitro Finally, we f

269 This implies that the IDR content and the amino acid composition of IDRs exper

270 We found that the IDR of Cdc15 is essential for viability and cannot be re

271 We found that CaM binds directly to the IDR in the C-terminal domain of prestin in a calcium-obl

272 f the CCP-like domain does contribute to the IDR.

273 the minor substitutions observed within the IDR of gp41 of HIV-1 group M subtypes do not affect anti

274 tify the SLiM bound by RCD1, we analyzed the IDRs in three protein partners, DREB2A (dehydration-resp

275 onse to signaling is mediated in part by the IDRs of the signaling factors, which cause these factors

276 stem to study condensed phases driven by the IDRs of various RNP body proteins, including FUS, DDX4,

277 rable and unfavorable contributions from the IDRs surrounding the SLiM to the interactions with RCD1,

278 Moreover, the IDRs also regulate the adenosine triphosphate hydrolysis

279 Shortening or scrambling the IDRs in both subunits ablates MMR in vivo.

280 motifs (SLiMs) that are embedded within the IDRs.

281 is fine-tuned by phosphorylation within the IDRs.

282 yingly stable structural elements within the IDRs.

283 DRs flanking its catalytic domain, and these IDRs similarly contain binding modules important for pro

284 However, these IDRs have only been thought of as linkers that allow fle

285 The conformational properties of these IDRs prior to and following multisite phosphorylation ar

286 these results support a model in which this IDR of Med13 plays a key role in controlling a molecular

287 ural cationic amino acid moieties throughout IDR-1018.

288 Thus IDR provides both a novel on-line resource and a softwar

289 Homology to IDR-containing proteins implicated in DNA damage repair

290 These varying responses to IDR, DNR, and MTA indicate that the MiCK assay results c

291 se-response analyses of the sensitivities to IDR, DNR, and MTA of leukemia cells from 4 other patient

292 across the whole board and more sensitive to IDRs longer than 20 amino acids.

293 Topical IDR-1002 treatment successfully dampened PMA-induced ear

294 onoclonal autoantibodies that define the TPO IDR, as well as polyclonal TPO autoantibodies in patient

295 We found that the wild-type IDR promotes LLPS of the polySH3-polyPRM system, decreas

296 n both instances, treatment of CF cells with IDR-1018 abolished the accumulation of LC3 induced by Fl

297 ntent, the more frequently it interacts with IDR-containing partners, and the more functionally diver

298 were analyzed in pups that were treated with IDR-1018 either 4 hours before LPS or 3 hours after LPS+

299 We propose that sequence features within IDRs have evolved to ensure an optimal balance of sequen

300 ly more readmissions than the group without (IDR 1.39 [95% CI 1.07-1.79]) and we noted no significant