ライフサイエンスコーパス: IFN regulatory factor-3

1 ctivation of the transcription factor IRF-3 (IFN regulatory factor 3).

2 TBK1, TAK1, and phosphorylation of TBK1 and IFN regulatory factor 3.

3 IFN production in vitro, acting upstream of IFN regulatory factor 3.

4 infected cells are prevented from activating IFN regulatory factor 3.

5 resulting in inhibition of signaling through IFN regulatory factor 3.

6 molecule STING and the transcription factor IFN regulatory factor 3.

7 at specifically phosphorylates and activates IFN regulatory factor 3.

8 ds to activity-associated phosphorylation of IFN regulatory factor-3.

9 phosphorylation and nuclear translocation of IFN regulatory factor-3.

10 nhancement of reporter activity by predicted IFN regulatory factor 3/7 binding sites in the CAD risk

11 assay; and 3) enhancer activity of predicted IFN regulatory factor 3/7 binding sites within the 9p21

12 suppressed IFN-I signaling via an AKT/FOXO3/IFN regulatory factor 3/7 pathway.

13 It also activates IFN regulatory factor 3/7 through its interaction with T

14 sh IFN; however, it does so in an apparently IFN regulatory factor 3/7-independent manner.

15 umulation without inhibiting dimerization of IFN regulatory factor 3, a protein that is essential for

16 IFN regulatory factor 3, a transcription factor that is

17 tion and increases LPS-induced NF-kappaB and IFN regulatory factor 3 activation and IL-10 secretion,

18 complex formation and facilitating TBK1 and IFN regulatory factor 3 activation and the induction of

19 n sMLA-induced IkappaB kinase alpha/beta and IFN regulatory factor 3 activation and with restrained e

20 e regulator of the TRIF pathway via reducing IFN regulatory factor 3 activation.

21 and S1P1 acting through PI3K enhancement of IFN-regulatory factor 3 activation increase IFN-beta exp

22 Furthermore, we found that IFN-regulatory factor 3 activation was maximized by LPS

23 enhanced AKT, Rac, P21-activated kinase, and IFN regulatory factor 3 activities.

24 Both IFN regulatory factor 3 and 7 (IRF-3 and IRF-7) were sug

25 e ability of NP to suppress translocation of IFN regulatory factor 3 and block activation of the inna

26 ion, which coincides with phosphorylation of IFN regulatory factor 3 and caspase-1 cleavage.

27 ence of the transcriptional factors RelA and IFN regulatory factor 3 and IkappaB kinases.

28 y C-HIV, which instead induced activation of IFN regulatory factor 3 and Lyn.

29 which ablates RIG-I signaling of downstream IFN regulatory factor 3 and NF-kappaB activation, attenu

30 RIG-I supports HCV persistence by preventing IFN regulatory factor 3 and NF-kappaB activation.

31 hat viperin/cig5 expression was dependent on IFN regulatory factor 3 and NF-kappaB signaling, and tha

32 g of KIN1148 to RIG-I to drive expression of IFN regulatory factor 3 and NF-kappaB target genes, incl

33 of type I interferons through activation of IFN regulatory factor 3 and NFkappaB.

34 e induction of type III IFNs is regulated by IFN regulatory factor 3 and nuclear factor kappaB.

35 ttenuated the LPS-induced phosphorylation of IFN regulatory factor 3 and nuclear factor-kappaB.

36 inhibit the MyD88-independent activation of IFN regulatory factor 3 and production of IFN-beta in re

37 ing phosphorylation of TANK-binding kinase 1/IFN regulatory factor 3 and production of IFN-beta.

38 , IFNbeta production, and phosphorylation of IFN regulatory factor 3 and TANK-binding kinase 1.

39 The activation of IFN regulatory factor 3 and the expression of IFN-beta i

40 n the activation of the transcription factor IFN regulatory factor 3 and the molecule UNC93B1, indica

41 site 6.1 kb downstream of ifnb1, along with IFN regulatory factor-3 and CREB binding protein only du

42 In contrast, LPS-induced phosphorylation of IFN regulatory factor-3 and expression of IFN-beta or th

43 ts displayed a significantly higher level of IFN regulatory factor-3 and NF-kappaB activity compared

44 l signaling protein, nuclear localization of IFN regulatory factor 3, and augmentation of IFN-stimula

45 inding kinase 1, activation of NF-kappaB and IFN regulatory factor 3, and induction of IL-8 and IFN-b

46 eta depended on the downstream transcription IFN regulatory factor 3, and on activation of NF-kappaB

47 TLR4 pathway in monocytes by activating Syk, IFN regulatory factor 3, and STAT1, which resulted in en

48 ons with the IPS-1 adaptor protein to signal IFN regulatory factor 3- and NF-kappaB-responsive genes.

49 IFN-beta transcription factors NF-kappaB and IFN regulatory factor 3 are not activated for nuclear tr

50 Similarly, phosphorylation of IkappaB and IFN regulatory factor 3 as well as cytokine expression w

51 ll-like receptor 4 signaling, and subsequent IFN regulatory factor 3 binding to IFN-beta promoter.

52 Our results show that IFN regulatory factor 3, but not MyD88, mediated IRI-ind

53 mDCs blocked the activation of NF-kappaB and IFN regulatory factor 3 by dsRNA.

54 n-induced ER stress augmented recruitment of IFN regulatory factor-3, CREB binding protein/p300, and

55 tratricopeptide repeats (IFITs) 1 and 2, and IFN regulatory factor 3 decreased in these cells.

56 irectly present Ag to CD8 T cells through an IFN-regulatory factor 3-dependent process.

57 Polyinosinic-polycytidylic acid activated IFN regulatory factor 3 dimerization and phosphorylation

58 d nonimmune cells that converges on TBK1 and IFN regulatory factor 3 for activation of IFN-beta gene

59 ain-containing adapter inducing IFN-beta --> IFN regulatory factor 3 --> type I IFN is the major axis

60 IFN-beta (TRIF)-dependent phosphorylation of IFN regulatory factor 3 in addition to TIR-containing ad

61 regates that led to activation of STAT-1 and IFN regulatory factor-3 in human macrophages, indicating

62 nslocation of transcription factors RelA and IFN regulatory factor-3 in IFN-alpha-primed HUVECs befor

63 underwent nuclear translocation of RelA and IFN regulatory factor-3 in response to dsRNA, whereas le

64 uated activation of the transcription factor IFN regulatory factor 3, involved in the MyD88-independe

65 ed cells was caused by an early block in the IFN regulatory factor 3 (IRF-3) activation pathway.

66 The level of IFN induction correlated with IFN regulatory factor 3 (IRF-3) activation, in that IRF-

67 g TLR3 to kinases responsible for activating IFN regulatory factor 3 (IRF-3) and NF-kappaB, transcrip

68 on activated both transcription factors, the IFN regulatory factor 3 (IRF-3) and nuclear factor kappa

69 upt IFN-beta gene transcription induction by IFN regulatory factor 3 (IRF-3) but do so at different p

70 ole of the IKK-related kinase IKKepsilon and IFN regulatory factor 3 (IRF-3) in the activation of ant

71 Mice lacking IFN regulatory factor 3 (IRF-3) show increased vulnerabi

72 LP by dsRNA was dependent upon NF-kappaB and IFN regulatory factor 3 (IRF-3) signaling via TLR3 as in

73 Expression of IFN regulatory factor 3 (IRF-3) stimulated transcription

74 ay partially involve limiting the ability of IFN regulatory factor 3 (IRF-3) to function as a transcr

75 its downstream signaling molecules TRIF and IFN regulatory factor 3 (IRF-3) using a dominant-negativ

76 interacts with the host transcription factor IFN regulatory factor 3 (IRF-3), inhibiting its phosphor

77 us correlated with an enhanced activation of IFN regulatory factor 3 (IRF-3), NF-kappaB, and ATF-2 in

78 and chemokine genes in a manner dependent on IFN regulatory factor 3 (IRF-3), TANK-binding kinase 1 (

79 y induce the type I IFN cascade, often in an IFN regulatory factor 3 (IRF-3)-dependent fashion.

80 ection-induced transcriptional activation of IFN regulatory factor 3 (IRF-3)-responsive mammalian pro

81 layed activation of the transcription factor IFN regulatory factor 3 (IRF-3).

82 IFN promoter-stimulator 1 (IPS-1), activates IFN regulatory factor-3 (IRF-3) and the host IFN-alpha/b

83 rotein expression consistent with a role for IFN regulatory factor-3 (IRF-3) in the expression of IL-

84 IFN regulatory factor-3 (IRF-3) is a transcription facto

85 In these cells, IFN regulatory factor-3 (IRF-3) undergoes a sequence of

86 ells without inducing the phosphorylation of IFN-regulatory factor 3 (IRF-3), a latent cellular trans

87 promoter by blocking the phosphorylation of IFN-regulatory factor 3 (IRF-3), a transcription factor

88 We show that influenza B virus induces IFN regulatory factor 3 (IRF3) activation and IFN-lambda

89 TRIF)-dependent signaling pathway leading to IFN regulatory factor 3 (IRF3) activation and induction

90 Early activation of IFN regulatory factor 3 (IRF3) and NF-kappaB was observe

91 compound, KIN1148, led to the activation of IFN regulatory factor 3 (IRF3) and served to enhance pro

92 vation of the cellular transcription factors IFN regulatory factor 3 (IRF3) and signal transducers an

93 ting IFN production and signaling, including IFN regulatory factor 3 (IRF3) and STAT1.

94 Consistent with this, the phosphorylation of IFN regulatory factor 3 (IRF3) and the production of IFN

95 , to form a signaling complex that activates IFN regulatory factor 3 (IRF3) for transcriptional induc

96 genes, and in all systems examined thus far, IFN regulatory factor 3 (IRF3) has been described as an

97 IFN regulatory factor 3 (IRF3) is a transcription factor

98 , TLR4, TLR2/4, MyD88, TRIF, MyD88/TRIF, and IFN regulatory factor 3 (IRF3) KO mice, treated them wit

99 H5N1 viruses elicited significantly less IFN regulatory factor 3 (IRF3) nuclear translocation, as

100 ch inhibit IFN induction by targeting either IFN regulatory factor 3 (IRF3) or NF-kappaB, respectivel

101 Using IFN regulatory factor 3 (IRF3) phosphorylation as a mark

102 IFN regulatory factor 3 (IRF3) regulates early type I IF

103 PEITC preferentially inhibited TLR3-mediated IFN regulatory factor 3 (IRF3) signaling and downstream

104 ntially reduced binding of these factors and IFN regulatory factor 3 (IRF3) to IFN-beta or ISGs promo

105 IFN regulatory factor 3 (IRF3), a constitutively express

106 Data in this study show that cFLIPL inhibits IFN regulatory factor 3 (IRF3), a transcription factor c

107 tly of MyD88, resulting in the activation of IFN regulatory factor 3 (IRF3), a transcription factor r

108 B activation and virus-induced activation of IFN regulatory factor 3 (IRF3), whereas bone marrow-deri

109 NSP1beta was found to inhibit both IFN regulatory factor 3 (IRF3)- and NF-kappaB-dependent

110 I interferons (IFNs), despite maintenance of IFN regulatory factor 3 (IRF3)-dependent IFN-stimulated

111 beta interferon (IFN-beta) promoter and the IFN regulatory factor 3 (IRF3)-responsive IFN-stimulated

112 tor kappa-B kinase epsilon (IKKepsilon), and IFN regulatory factor 3 (IRF3).

113 ween the transcription factors NF-kappaB and IFN regulatory factor 3 (IRF3).

114 y of critical cellular proteins that include IFN regulatory factor 3 (IRF3).

115 on in mammalian cells requires activation of IFN regulatory factor 3 (IRF3).

116 ppression of early IFN signaling mediated by IFN regulatory factor 3 (IRF3).

117 promoter activity and induces degradation of IFN regulatory factor 3 (IRF3).

118 FN) response by inhibiting activation of the IFN regulatory factor 3 (IRF3).

119 e-associated pathway, both of which activate IFN regulatory factor 3 (IRF3).

120 nscription directed by constitutively active IFN regulatory factor-3 (IRF3).

121 of several transcription factors, including IFN-regulatory factor 3 (IRF3).

122 K1) and its downstream transcription factor, IFN-regulatory factor 3 (IRF3).

123 y the activation of constitutively expressed IFN regulatory factor 3, IRF3, which in turn leads to th

124 infection, type I IFN signaling by STING and IFN regulatory factor 3 is detrimental to the host durin

125 y, we report that signaling through TBK1 and IFN regulatory factor 3 is required for T. cruzi-mediate

126 nse to a self-Ag, DC-intrinsic expression of IFN regulatory factor 3 is required to induce optimal pr

127 after infection with influenza A virus, but IFN regulatory factor-3 is activated and the transcripti

128 of the transcription factors, NF-kappaB and IFN regulatory factor 3, leading to proinflammatory cyto

129 egatively regulate TANK-binding kinase 1 and IFN regulatory factor 3 mediated by TLR4.

130 We have recently described an IFN regulatory factor 3-mediated antiviral gene program

131 me-edited knockout human cells, we show that IFN regulatory factor 3-mediated IFN induction and downs

132 Functional genetic analyses revealed that IFN regulatory factor 3-mediated pathways that resulted

133 by dampening the activation of NF-kappaB and IFN regulatory factor 3-mediated production of proinflam

134 MOV10 enhanced IFN regulatory factor 3-mediated transcription of IFN.

135 require STING, culminating in activation of IFN regulatory factor 3, NF-kappaB, and p38 MAPK.

136 nal IFN were also produced in VLP-inoculated IFN regulatory factor 3 null (IRF3(-/-)) mice, indicatin

137 pression of TRAM-G2A failed to elicit either IFN regulatory factor 3 or NF-kappaB signaling.

138 dependent on its ability to activate either IFN regulatory factor-3 or NF-kappa B but was dependent

139 ining adaptor inducing interferon (IFN) beta-IFN regulatory factor 3 pathway induce less IL-10, and a

140 domain-containing adapter inducing IFN-beta-IFN regulatory factor 3 pathway is required for Ezrin-de

141 we demonstrate the requirement for the TBK1-IFN regulatory factor-3 pathway in host defense against

142 duced activation of the NF-kappaB, MAPK, and IFN regulatory factor-3 pathways and decreased TLR4 degr

143 G aggregation, and TANK-binding kinase 1 and IFN regulatory factor 3 phosphorylation in inflammasome-

144 ANK-binding kinase-1, resulting in decreased IFN regulatory factor 3 phosphorylation.

145 ocation of MAVS to the cytosol and decreased IFN regulatory factor 3 phosphorylation.

146 nt in melanoma 2, DNA-dependent activator of IFN regulatory factor 3, RNA polymerase III, or high-mob

147 IFN-beta, the TLR3 adaptor protein linked to IFN regulatory factor 3 signaling.

148 r DMXAA leading to TANK-binding kinase 1 and IFN regulatory factor 3 signaling.

149 and NF-kB, but not TANK-binding kinase 1 and IFN regulatory factor 3, thereby inducing the expression

150 NF-kappaB, but not TANK-binding kinase 1 and IFN regulatory factor 3, thereby inducing the expression

151 protein, MAVS, that activates NF-kappaB and IFN regulatory factor 3 to induce type-I interferons.

152 so required for gene induction driven by the IFN regulatory factor 3 transcription factor activated b

153 RIF-dependent pathways through NF-kappaB and IFN regulatory factor 3 transcription factors, respectiv

154 Consequently, the IFN regulatory factor-3 transcription factor, which is r

155 iates with TANK-binding kinase 1 to regulate IFN regulatory factor 3 translocation and phosphorylatio

156 signaling pathways, IL-15, TNF, IL-1, IL-6, IFN regulatory factor 3, type I IFN receptor, adaptive i

157 Specific interaction between KSHV viral IFN regulatory factor 3 (vIRF3) and the HIF-1 alpha subu

158 The activation of NF-kappaB or IFN regulatory factor 3 was found to be unaffected by th

159 he absence of DOK3, the transcription factor IFN regulatory factor 3 was not phosphorylated and could

160 apoptosis could activate NF-kappa B but not IFN regulatory factor-3, yet the activation of NF-kappa