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1                                              IKK alpha was not required for RANKL-mediated I kappa B
2                                              IKK-alpha and IKK-beta formed heterodimers that interact
3                                              IKK-alpha and IKK-beta isozymes are found in large compl
4                                              IKK-alpha interacts with CREB-binding protein and in con
5                                              IKK-alpha was independently discovered as a NF-kappaB-in
6                                              IKK-alpha, however, does not relocate to the LD but tran
7                      Furthermore, caspase-8, IKK-alpha, and NF-kappaB p65 knockdown or dominant negat
8 lts in production of cytokines that activate IKK-alpha and STAT3 in CaP cells to enhance hormone-free
9  polypeptide 3, X-linked (DDX3X) to activate IKK-alpha, which translocates to the nucleus and induces
10 ow that MEKK2 and MEKK3 can in vivo activate IKK-alpha and IKK-beta, induce site-specific IkappaBalph
11 hat DDX3X binds to the HCV 3'UTR, activating IKK-alpha and cellular lipogenesis to facilitate viral a
12 Here, by using a monoclonal antibody against IKK-alpha, we purify the IKK complex to homogeneity from
13 igated the effect of inhibiting the PI3K/AKT/IKK alpha pathway in regulating the inappropriate consti
14 rm of the inhibitor of kappa B kinase alpha (IKK alpha) have mammary gland defects similar to those o
15 pha-induced inhibitory kappa B kinase alpha (IKK-alpha) activation, which, in turn, resulted in a ste
16 entified two proteins, IkappaB kinase alpha (IKK-alpha) and IkappaB kinase beta (IKK-beta), that are
17                        IkappaB kinase-alpha (IKK-alpha) and Mitogen- and Stress-activated protein Kin
18                        IkappaB kinase-alpha (IKK-alpha) exhibits protein-kinase-dependent and -indepe
19 reen demonstrated that IkappaB kinase-alpha (IKK-alpha) is a crucial host factor for HCV.
20 uclear factor-kappaB (IkappaB) kinase-alpha (IKK-alpha), a protein kinase that is needed for the self
21 ucing kinase (NIK) and IkappaB kinase-alpha (IKK-alpha).
22  but our results suggest that it involves an IKK alpha/IKK beta-independent mechanism.
23 appa B alpha phosphorylation/degradation and IKK alpha/beta and RelA phosphorylation in primary IEC d
24 dent on NF-kappa B-inducing kinase (NIK) and IKK alpha.
25 ed that IKK gamma/NEMO competed with p65 and IKK alpha for binding to the N terminus of CBP, inhibiti
26 ction, the HCV 3'UTR redistributes DDX3X and IKK-alpha to speckle-like cytoplasmic structures shown t
27 tion, the HCV 3'UTR interacts with DDX3X and IKK-alpha, which redistribute to speckle-like cytoplasmi
28 tors of IKK-alpha suppress HCV infection and IKK-alpha-induced lipogenesis, offering a proof-of-conce
29  protein 1 (LRP1), and the NF-kappaB p65 and IKK-alpha/beta signaling pathways in modulating neuroinf
30 e therefore examined whether RANKL, RANK and IKK-alpha are also involved in mammary/breast cancer met
31              IkappaB kinase-alpha and -beta (IKK-alpha and IKK-beta), the catalytic subunits of the I
32  composed of IkappaB kinase beta (IKK-beta), IKK-alpha, and IKK-gamma/N, leading to changes in NF-kap
33 her kinase dead (KD) IKK alpha, which blocks IKK alpha kinase activity, KD AKT, which blocks AKT acti
34                               Moreover, both IKK-alpha and -beta were activated by hematopoietic prog
35 that MEKK1 can induce the activation of both IKK-alpha and IKK-beta in vivo.
36 d is dependent on phosphorylation of p100 by IKK alpha.
37 s composed of a heterodimer of the catalytic IKK alpha and IKK beta subunits and a presumed regulator
38                              In these cells, IKK alpha associates with mTOR, as part of the TORC1 com
39 rted tumor suppressor kinases, such as chk2, IKK-alpha, p38 MAPKs, and DAPK2.
40 ctivating inhibitor of kappaB kinase complex IKK-alpha/beta and active transcription factor NF-kappaB
41 ly controlled by the IkappaB kinase complex (IKK-alpha/beta/gamma).
42 ddition to failed epidermal differentiation, IKK-alpha-deficient mice exhibit abnormal skeletal and c
43 ctivate NF kappa B without activating either IKK alpha or IKK beta.
44 g mouse embryonic fibroblasts lacking either IKK alpha or IKK beta, we found that IKK beta played an
45 dition, dominant negative versions of either IKK-alpha or IKK-beta abolish NF-kappaB activation induc
46 ving dynamic associations with HCV elements, IKK-alpha, SGs, and LDs for its critical role in HCV inf
47        The results indicate a novel role for IKK alpha in controlling mTOR function in cancer cells w
48      However, recent data suggest a role for IKK-alpha in NF-kappaB-dependent gene expression in resp
49 r the levels of phosphorylated c-Jun, c-Fos, IKK-alpha/beta, and p65.
50 ct endogenous IKK complexes, a heterodimeric IKK alpha/beta and a homodimeric IKK beta complex.
51 e nuclear factor kappaB/IkappaB cascade (ie, IKK-alpha,-beta,-gamma/NEMO and CARMA/MALT1/Bcl10 comple
52 lls lacking either catalytic subunit of IKK (IKK-alpha or IKK-beta) fail to induce autophagy in respo
53 uced activation of the IkappaB kinases (IKK) IKK-alpha and IKK-beta is a key step involved in the act
54 gene expression was significantly blunted in IKK alpha(-/-) cells, including osteoclast-specific gene
55 lpha can overcome p100 processing defects in IKK alpha(-/-) cells.
56 ed to directly examine osteoclastogenesis in IKK alpha(-/-) mice.
57 postulated that the morphogenetic defects in IKK-alpha-deficient mice are not caused by reduced NF-ka
58 eless, mouse embryo fibroblasts deficient in IKK-alpha are defective in the induction of NF-kappaB-de
59                            LMP1 also induced IKK alpha-mediated p100 processing and p52 nuclear local
60 e activity of IL-1beta and TNF-alpha induced IKK-alpha/beta towards NF-kappaB p65, resulting in a red
61                               Interestingly, IKK-alpha and MSK1/2 have also been implicated as histon
62 fic Ikka (also known as Chuk) transgene into IKK-alpha-deficient mice.
63            Inducible expression of either KD IKK alpha or WT PTEN strongly inhibits both the constitu
64                            The ability of KD IKK alpha, KD AKT or WT PTEN to decrease beta-catenin-de
65 siently transfecting either kinase dead (KD) IKK alpha, which blocks IKK alpha kinase activity, KD AK
66 omplex, which is composed of the two kinases IKK alpha and IKK beta and the regulatory subunit IKK ga
67 D40 engagement activated the IkappaB kinases IKK-alpha and IKK-beta and stimulated IkappaBalpha phosp
68 rgeted for degradation by I kappa B kinases (IKK alpha and IKK beta).
69 hibitory factor IkappaBs by IkappaB kinases (IKK-alpha and -beta).
70 A clones encoding these two IkappaB kinases, IKK-alpha and IKK-beta.
71 ducing kinase (NIK) and two IkappaB kinases, IKK-alpha and IKK-beta.
72               IKK is made up of two kinases, IKK-alpha and IKK-beta, which phosphorylate I(kappa)B, l
73            Because mice that completely lack IKK alpha have severe skin and skeletal defects that are
74                                 Mice lacking IKK-alpha in all cell types including bone and cartilage
75  construct with either the dominant negative IKK-alpha or the repressors of NF-kappaB, the IkappaB-al
76       Here we show that Tax binds to neither IKK-alpha nor IKK-beta but instead complexes directly wi
77 ivation of NF-kappa B inducing kinase (NIK)--IKK alpha/beta complex leading to I kappa B alpha phosph
78 -1-inducible IKK complexes that contain NIK, IKK-alpha, IKK-beta, IkappaB-alpha, NF-kappaB/RelA and a
79              Bifurcation of NTHi-induced NIK-IKK alpha/beta-I kappa B alpha and MKK3/6--p38 MAP kinas
80 ates NF-kappa B via TLR2-TAK1-dependent NIK--IKK alpha/beta-I kappa B alpha and MKK3/6--p38 MAP kinas
81                                          NIK/IKK-alpha axis regulated the activation of both NF-kappa
82                                Moreover, NIK/IKK-alpha/NF-kappaB p50/p65 axis mediated the TNF-alpha-
83        In conclusion, our data show that NIK/IKK-alpha/regulates the activation of NF-kappaB p50/p65
84 alicylate, an inhibitor of IKK beta, but not IKK alpha, activity, inhibited IL-2 promoter activation
85 1 also induced transfected IKK beta, but not IKK alpha, activity.
86                  Moreover, IKK beta, but not IKK alpha, overexpression enhanced transcriptional activ
87  IKK genes have shown that IKK-beta, but not IKK-alpha, is critical for cytokine-induced IkappaB degr
88 kappa B alpha turnover and the activities of IKK alpha and IKK beta.
89           In contrast, ectopic expression of IKK alpha assembled into a complex with negligible I kap
90 hibit NF-kappaB activation via inhibition of IKK alpha or IKK beta, whereas proteosome inhibitors ins
91              Cells with a high proportion of IKK alpha (the IKK kinase activated by Akt) to IKK beta
92 -/- or wild-type cells in which the ratio of IKK alpha to IKK beta is low.
93                 Expression and the ratios of IKK alpha and IKK beta, which homo- and heterodimerize,
94                                 Treatment of IKK alpha(-/-) cells with tumor necrosis factor alpha (T
95  Here we demonstrate nuclear accumulation of IKK-alpha after cytokine exposure, suggesting a nuclear
96 d region (UTR), leading to the activation of IKK-alpha and a cascade of lipogenic signaling to facili
97  over IKK-beta, leading to the activation of IKK-alpha kinase activity.
98  inflammatory infiltration and activation of IKK-alpha, which stimulates metastasis by an NF-kappaB-i
99 d that IKK is composed of similar amounts of IKK-alpha, IKK-beta and two other polypeptides, for whic
100 fically elevated in the limb bud ectoderm of IKK-alpha-deficient mice.
101 ugh the basal level of protein expression of IKK-alpha or IKK-beta are the same in both Hs294T and RP
102                             A mutant form of IKK-alpha containing alanine at residue 176 cannot be ph
103                 Conversely, a mutant form of IKK-alpha containing glutamic acid at residue 176 is con
104 dent and kinase-mediated nuclear function of IKK-alpha in HCV assembly.
105                       Chemical inhibitors of IKK-alpha suppress HCV infection and IKK-alpha-induced l
106 gene expression is suppressed by the loss of IKK-alpha and this correlates with a complete loss of ge
107 nce of TNF-alpha solely by overexpression of IKK-alpha/beta or strong activation of NF-kappaB.
108 omplex with MEKK1 induces phosphorylation of IKK-alpha in vitro.
109                      This phosphorylation of IKK-alpha occurs specifically on Ser-176 in the activati
110                 Thus, the phosphorylation of IKK-alpha on Ser-176 by NIK may be required for cytokine
111 erase promoter assays and phosphorylation of IKK-alpha/beta.
112   These results define a new nuclear role of IKK-alpha in modifying histone function that is critical
113  osteoclast differentiation was dependent on IKK alpha, suggesting that synergy between RANKL and TNF
114 ull mice, which completely lack osteoclasts, IKK alpha(-/-) mice did possess normal numbers of TRAP(+
115 ar activity and significant selectivity over IKK-alpha.
116  show that NIK preferentially phosphorylates IKK-alpha over IKK-beta, leading to the activation of IK
117 amic associations with HCV RNA and proteins, IKK-alpha, SG, and LD surfaces for its crucial role in t
118              We show herein that recombinant IKK-alpha and IKK-beta can, in fact, directly phosphoryl
119  PKK-mediated NF-kappa B activation required IKK alpha and IKK beta but not IKK gamma, the regulatory
120 g of IKKgamma to the IKK catalytic subunits, IKK-alpha and -beta, and attenuates the IKK catalytic ac
121                              These subunits, IKK-alpha and IKK-beta, are protein kinases whose functi
122 anced activation of the protein kinases TAK, IKK-alpha/beta, c-Jun N-terminal kinases, and p38alpha m
123                    The experiments show that IKK alpha controls mTOR kinase activity in Akt-active, P
124 nd regulation of NF-kappaB activity and that IKK-alpha can only partially compensate for the loss of
125                             We conclude that IKK-alpha and IKK-beta can mediate the NF-kappaB-inducin
126                              We propose that IKK-alpha is an essential regulator of NF-kappaB-depende
127 mmunoprecipitation (ChIP) assays reveal that IKK-alpha was recruited to the promoter regions of NF-ka
128                    Furthermore, we show that IKK-alpha can directly phosphorylate histone H3 in vitro
129                            Here we show that IKK-alpha functions in the nucleus to activate the expre
130                        Finally, we show that IKK-alpha is present in the MEKK1-inducible, high molecu
131                               We showed that IKK-alpha and IKK-beta were coexpressed in most human ad
132 a B kinase (IKK) complex, which includes the IKK alpha (IKK-1) and IKK beta (IKK-2) kinases.
133 gnals in NK cells involves activation of the IKK alpha kinase, inhibitory protein kappa B alpha degra
134                                          The IKK-alpha and IKK-beta genes are distinct but evolutiona
135  expression was accompanied by dampening the IKK-alpha/beta-NF-kappaB p65 pathway, resulting in decre
136                                Moreover, the IKK-alpha gene locus was mapped to human chromosome 10q2
137 KK epsilon, two kinases distantly related to IKK alpha/beta, but the underlying mechanisms remained u
138 s identified that is 52 percent identical to IKK-alpha.
139 dapting an oncoprotein-specific signaling to IKK-alpha and IKK-beta.
140 teoclastogenesis was observed in vitro using IKK alpha(-/-) hematopoietic cells treated with colony-s
141                       We found that, whereas IKK alpha is a weak kinase for the N-terminal serines of
142 osphorylated IkappaB constitutively, whereas IKK-alpha was not active in the absence of cell stimulat
143 cytokine-induced NF-kappaB function, whereas IKK-alpha is thought to be involved in other regulatory
144  observations raised the question of whether IKK-alpha might regulate a previously undescribed step t
145                             One way by which IKK-alpha controls skeletal and craniofacial morphogenes
146 ced p65 phosphorylation on serine 536, while IKK alpha was partially required for the p65 phosphoryla
147 keletal defects that are not associated with IKK alpha-kinase activity, we wished to directly examine
148 294T and RPE cells, immunoprecipitation with IKK-alpha antibody combined with activity assay reveal a
149 the truncated NEMO protein interactions with IKK-alpha, IKK-beta, TNF receptor-associated factor 6, T

 
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