ライフサイエンスコーパス: IL-17 receptor

1 cient in Del-1 and LFA-1 or in Del-1 and the IL-17 receptor.

2 d tumor-associated stromal cells, which bear IL-17 receptors.

3 , such as allergic asthma, and requires both IL-17 receptor A (IL-17RA) and IL-17RB to elicit functio

4 es protective immune responses by binding to IL-17 receptor A (IL-17RA) and IL-17RC subunits.

5 radoxically induced from treatment with anti-IL-17 receptor A (IL-17RA) antibodies, promote anxiogeni

6 G-CSF, its receptor, and IL-17 receptor A (IL-17RA) are all required to maintain

7 resent the crystal structure of a complex of IL-17 receptor A (IL-17RA) bound to IL-17F in a 1:2 stoi

8 didiasis underscore the preponderant role of IL-17 receptor A (IL-17RA) in preserving mucocutaneous i

9 ttenuates Crohn's disease, whereas IL-17A or IL-17 receptor A (IL-17RA) inhibition exacerbates Crohn'

10 We have found that although IL-17 receptor A (IL-17RA)(-/-) mice were resistant to e

11 Unlike IL-17 receptor A (IL-17RA), which heterodimerizes with I

12 We demonstrate here that IL-23 and the IL-17 receptor A (IL-17RA), which mediates both IL-17A a

13 eneration of airway smooth muscle through an IL-17 receptor A (IL-17RA)-IL-17RC, nuclear factor kappa

14 Inhibition of IL-17 receptor A did not produce a treatment effect in s

15 Accordingly, depleting BAMs, deleting IL-17 receptor A in brain macrophages or suppressing men

16 onses to IL-17A signaling, either because of IL-17 receptor A knockout or wild-type animals that rece

17 RPE-specific knockout of IL-17 receptor A led to the dysfunction of subretinal mi

18 Apoe(-/-) mice by use of adenovirus-produced IL-17 receptor A reduced plaque burden in Apoe(-/-) mice

19 s by infecting C3H mice devoid of the common IL-17 receptor A subunit (IL-17RA) and thus deficient in

20 h brodalumab, a competitive inhibitor of the IL-17 Receptor A subunit.

21 ity to the human interleukin-23 (IL-23R) and IL-17 receptor A were used.

22 n 11c (CD11c)/diphtheria toxin receptor, and IL-17 receptor A(-/-) mice were used to examine T-lympho

23 the fact that disruption of IL-17 signaling (IL-17 receptor A(-/-)) prevented airway neutrophilia in

24 ge peritoneal macrophages, were enriched for IL-17 receptor A, and for protumor and proangiogenic mol

25 ith BA, cholangiocytes were found to express IL-17 receptor A, and the prevalence of IL-17A(+) cells

26 jury directly signals to sensory neurons via IL-17 receptor A, the transcription of which is specific

27 gene expression in vitro, and this requires IL-17 receptor A, tumor necrosis factor receptor-associa

28 s evident in mice deficient in IL-17A or the IL-17 receptor A, which mediates IL-17A signaling, follo

29 t (Apoe(-/-)) mice with IL-17A-deficient and IL-17 receptor A-deficient mice to generate Il17a(-/-)Ap

30 interaction of IL-17A and/or IL-17F with the IL-17 receptor A/C (IL-17RA/C).

31 Their interactions with IL-17 receptors A-E (IL-17RA-E) mediate host defenses wh

32 Interleukin-17 (IL-17) receptor A signaling in Kupffer cells was require

33 IL-17 receptor-A antagonism caused extensive improvement

34 We sought to examine the effects of the IL-17 receptor-A antagonist brodalumab, on clinical and

35 Over-activating IL-17 receptors abnormally heightens responses to 21% ox

36 of IL-17 before challenge or absence of the IL-17 receptor abrogated the PA14DeltaaroA vaccine's pro

37 Without signaling via the IL-17 receptor, activated FRCs underwent cell cycle arre

38 gene encoding the gate-keeping interleukin (IL)-17 receptor adaptor.

39 The IL-17 receptor adaptor molecule Act1, an RNA-binding pro

40 wed that in the absence of signaling via the IL-17 receptor adaptor protein Act-1, the protective eff

41 for the formation for the signalosome of the IL-17 receptors and ACT1 critical for immune signaling.

42 omain containing proteins, which include the IL-17 receptors and an adaptor protein Act1, have essent

43 ) T cells, signaling via the interleukin-17 (IL-17) receptor, and IL-22 production.

44 Because IL-17A and IL-17F, ligands for IL-17 receptor antagonist (IL-17RA), have been shown to

45 y a clinically relevant dose/schedule of any IL-17-receptor antagonist.

46 ged IFN-gamma(0) mice were treated with anti-IL-17 receptor antibody or sequentially with anti-IL-17

47 ly with anti-IL-17 antibody followed by anti-IL-17 receptor antibody.

48 subunit dynamics, and ligand contacts of the IL-17 receptor are poorly defined.

49 eta and IL-4 express high levels of mRNA for IL-17 receptor B (IL-17RB), the receptor for IL-25.

50 ary infection, mice deficient in the surface IL-17 receptor B, a component of the IL-25R, exhibited i

51 ed kinase 1/2 (ERK1/2) signaling proximal of IL-17 receptor C (IL-17RC) activates mammalian target of

52 ice with an adipocyte-specific deficiency in IL-17 receptor C (IL-17RC) have defects in de novo lipog

53 We found that mice deficient in IL-17A, IL-17 receptor C (IL-17RC), and adaptor protein Act1 (of

54 ts role in prostate cancers by interbreeding IL-17 receptor C (IL-17RC)-deficient mice with mice that

55 ion of TGFbeta1 in parenchymal cells via the IL-17 receptor C (IL-17RC).

56 IL-17 receptor C and Pten double KO mice recapitulated t

57 ion of either IL-17 in RA synovial fluids or IL-17 receptor C on HMVECs significantly reduces the ind

58 Loss of IL-17 receptor C or Ab blockade of IL-17A was similarly

59 ube formation are mediated primarily through IL-17 receptor C.

60 ngly, deficiency of either C/EBPdelta or the IL-17 receptor caused kidney fibrosis to be enhanced.

61 als in macrophages and monocytes through the IL-17 receptor complex (IL-17RA, IL-17RC).

62 Act1 preferentially bound to IL-17 receptor complex, releasing its suppressive effect

63 Higher levels of IL-17 receptor, CXCR2 chemokines, and CXCR2 were observe

64 tal in this setting and tested the impact of IL-17 receptor deficiency or antibody-mediated neutraliz

65 IL-17 receptor-deficient mice showed increased systemic

66 On the other hand, Act1 and IL-17 receptor directly associate likely via homotypic i

67 stinct member of the IL-17 family that binds IL-17 receptor E/A to promote innate defense in epitheli

68 Furthermore, T cells deficient in the IL-17 receptor elicited an accelerated, aggressive wasti

69 rom septic human neonates, expression of the IL-17 receptor emerged as a critical regulatory node.

70 man fibroblasts and do not bind to the human IL-17 receptor extracellular domain.

71 The IL-17/IL-17 receptor family is the newest and least understood

72 We demonstrate here that IL-17 receptor family shares sequence homology in their

73 IL-17C bound to IL-17RE, a member of IL-17 receptor family whose full-length isoform was sele

74 tecture is a key organizing principle of the IL-17 receptor family.

75 lar domain of members of the interleukin-17 (IL-17) receptor family.

76 talloproteinases, the signaling mechanism of IL-17 receptor has not been understood.

77 e formation of GCs and that mice lacking the IL-17 receptor have reduced GC B cell development and hu

78 protein termed EVI27/IL-17BR, which we term IL-17 receptor homolog 1 (IL-17Rh1) in light of the mult

79 ence and functional similarities, this novel IL-17 receptor homologue represents a potential human SE

80 Deficiency in IL-23, IL-17A, or IL-17 receptor (IL-17R) and mAb neutralization of CXCR2,

81 Signaling through the IL-17 receptor (IL-17R) is required to prevent oropharyn

82 Furthermore, the levels of IL-17 receptor (IL-17R) on the TRAF6-deficient EFs were

83 gulation of the signal transduction from the IL-17 receptor (IL-17R) remained elusive.

84 l involvement of the adaptor protein Act1 in IL-17 receptor (IL-17R) signaling and IL-17-dependent im

85 Interleukin-17 (IL-17) and IL-17 receptor (IL-17R) signaling are essential for regu

86 We hypothesized that IL-17 receptor (IL-17R) signaling is critical for G-CSF

87 s pathogen by disrupting IL-17 production or IL-17 receptor (IL-17R) signaling.

88 a U-box E3 ubiquitin ligase, is recruited to IL-17 receptor (IL-17R) upon IL-17 stimulation and is re

89 cted corneas from wild-type mice, those from IL-17 receptor (IL-17R)-deficient mice had significantly

90 ntibodies to VEGF were rendered sensitive in IL-17 receptor (IL-17R)-knockout hosts deficient in T(H)

91 estigated the role of interleukin-17 (IL-17)/IL-17 receptor (IL-17R)-mediated signaling in the protec

92 ported that female C57BL/6J mice lacking the IL-17 receptor (IL-17RA(KO)) are significantly more susc

93 The signaling mechanisms triggered by the IL-17 receptor (IL-17RA) and related receptors are strik

94 The IL-17 receptor (IL-17RA) is expressed by diverse intesti

95 h interaction with its cognate receptor, the IL-17 receptor (IL-17RA).

96 we report that Act1, the key adaptor for the IL-17 receptor (IL-7R), formed a complex with the induci

97 The IL-17 receptors (IL-17Rs) play critical roles in immunit

98 okine receptor 2 (CXCR2) nor interleukin-17 (IL-17) receptor (IL-17R) deficiency changed the severity

99 naling complexes that function downstream of IL-17 receptors in C. elegans neurons.

100 was reversed in mice lacking both Del-1 and IL-17 receptor, indicating a crucial role for the IL-17/

101 IL-17 and IL-17 receptor inhibitors boast an impressive safety his

102 L-17 is restricted to activated T cells, the IL-17 receptor is found to be widely expressed, a findin

103 ntly, we observed that the expression of the IL-17 receptor is significantly increased in CTCL skin l

104 w levels of corneal miR-132 were detected in IL-17 receptor knockout mice after HSV infection.

105 hen these cells were cultured with BMMs from IL-17 receptor knockout mice.

106 ar domain since deletion mutants missing the IL-17 receptor-like domain lack this inhibitory effect.

107 s, the function of other IL-17 cytokines and IL-17 receptor-like molecules is unclear.

108 ed in the cerebrospinal fluid and activating IL-17 receptors on border-associated macrophages (BAMs).

109 Kras(G12D) induces expression of functional IL-17 receptors on PanIN epithelial cells and also stimu

110 ere, we confirmed that mice deficient in the IL-17 receptor or lacking the ability to secrete IL-17 a

111 17A or transplantation of grafts lacking the IL-17 receptor prevents disease.

112 -17 deficiency, or deletion of the adipocyte IL-17 receptor protect from infection-induced WAT wastin

113 ng the action of interleukin (IL) 17 with an IL-17 receptor (R):Fc fusion protein inhibits T-cell pro

114 TPL2 acts by linking the IL-17 receptor signal to the activation of TAK1, which i

115 coded by Zc3h12a) is a feedback inhibitor of IL-17 receptor signal transduction.

116 The IL-17 receptor signaling and specific arms of immunity p

117 y article is a commentary on "Th17 cells and IL-17 receptor signaling are essential for mucosal host

118 r NEC development, as inhibition of STAT3 or IL-17 receptor signaling attenuated NEC in mice, while I

119 Rather, mice lacking IL-17 receptor signaling had a cell-intrinsic impairment

120 se seemingly variegated processes by keeping IL-17 receptor signaling in check while supporting diffe

121 A key facet of IL-17 receptor signaling involves RNA-binding proteins,

122 Cytokine-targeted strategies blocking IL-17 receptor signaling may be beneficial in asthma tre

123 Mechanistically, IL-17 receptor signaling was required for the enhanced p

124 aB activator 1 (Act1), the key transducer of IL-17 receptor signaling, from the neuroectodermal linea

125 In the absence of IL-17 receptor signaling, IL-17ra(-/-) mice had delayed

126 In the absence of IL-17 receptor signaling, Il17ra(-/-) mice had significa

127 ion with segmented filamentous bacteria, and IL-17 receptor signaling.

128 or adaptive immunity (interleukin (IL)17-F, IL-17 receptor, STAT1, STAT3, antibodies to Th-17 cytoki

129 Conversely, abrogating the expression of IL-17 receptor subunit a (IL-17Ra) in the neurons of the

130 To date, only one IL-17 receptor subunit has been identified, termed IL-17

131 pe IL-2Rbeta, including up-regulation of the IL-17 receptor subunit IL-17RA.

132 h ubiquitin ligase activity that couples the IL-17 receptor to downstream signaling pathways.

133 ted directly on myeloma cells expressing the IL-17 receptor to induce a transcriptional landscape tha

134 wn what molecule(s) directly associates with IL-17 receptor to initiate the signaling.

135 rect binding of Act1, the adaptor protein of IL-17 receptor, to a stem-loop structure in the 3' untra

136 icate Act1 as a membrane-proximal adaptor of IL-17 receptor with an essential role in induction of in

137 ished the homotypic interaction of ACT1 with IL-17 receptors, with no effect on homodimerization.

138 ncreased levels of CXCR2, CXCR2 ligands, and IL-17 receptor within the metastatic lesions.